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Aliases for SAMD1 Gene

Aliases for SAMD1 Gene

  • Sterile Alpha Motif Domain Containing 1 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 1 4
  • SAM Domain-Containing Protein 1 4

External Ids for SAMD1 Gene

Previous GeneCards Identifiers for SAMD1 Gene

  • GC19U990301
  • GC19M014062
  • GC19M014199

Summaries for SAMD1 Gene

GeneCards Summary for SAMD1 Gene

SAMD1 (Sterile Alpha Motif Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SAMD13.

UniProtKB/Swiss-Prot for SAMD1 Gene

  • May play a role in atherogenesis by immobilizing LDL in the atherial wall.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD1 Gene

Genomics for SAMD1 Gene

Regulatory Elements for SAMD1 Gene

Enhancers for SAMD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SAMD1 on UCSC Golden Path with GeneCards custom track

Promoters for SAMD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAMD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SAMD1 Gene

14,087,840 bp from pter
14,091,036 bp from pter
3,197 bases
Minus strand

Genomic View for SAMD1 Gene

Genes around SAMD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD1 Gene

Proteins for SAMD1 Gene

  • Protein details for SAMD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6P0R3
    • Q6PIS7
    • Q96IM4

    Protein attributes for SAMD1 Gene

    538 amino acids
    Molecular mass:
    56052 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD1 Gene

Proteomics data for SAMD1 Gene at MOPED

Post-translational modifications for SAMD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAMD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAMD1 Gene

Domains & Families for SAMD1 Gene

Gene Families for SAMD1 Gene

Protein Domains for SAMD1 Gene


Suggested Antigen Peptide Sequences for SAMD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD1: view

Function for SAMD1 Gene

Molecular function for SAMD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in atherogenesis by immobilizing LDL in the atherial wall.

Phenotypes for SAMD1 Gene

genes like me logo Genes that share phenotypes with SAMD1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD1 Gene

Localization for SAMD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD1 Gene

Cytoplasm. Secreted.

Subcellular locations from

Jensen Localization Image for SAMD1 Gene COMPARTMENTS Subcellular localization image for SAMD1 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SAMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SAMD1: view

Pathways & Interactions for SAMD1 Gene

SuperPathways for SAMD1 Gene

No Data Available

Interacting Proteins for SAMD1 Gene

Gene Ontology (GO) - Biological Process for SAMD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SAMD1 Gene

Drugs & Compounds for SAMD1 Gene

No Compound Related Data Available

Transcripts for SAMD1 Gene

mRNA/cDNA for SAMD1 Gene

Unigene Clusters for SAMD1 Gene

Sterile alpha motif domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD1 Gene

No ASD Table

Relevant External Links for SAMD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAMD1 Gene

mRNA expression in normal human tissues for SAMD1 Gene

Protein differential expression in normal tissues from HIPED for SAMD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5), Fetal testis (9.8), Fetal Brain (7.5), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAMD1 Gene

SOURCE GeneReport for Unigene cluster for SAMD1 Gene Hs.140309

mRNA Expression by UniProt/SwissProt for SAMD1 Gene

Tissue specificity: Expressed in atherosclerotic lesions, not in normal intima.
genes like me logo Genes that share expression patterns with SAMD1: view

Protein tissue co-expression partners for SAMD1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SAMD1 Gene

Orthologs for SAMD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SAMD1 35
  • 89.27 (n)
  • 93.97 (a)
SAMD1 36
  • 69 (a)
(Mus musculus)
Mammalia Samd1 35
  • 85.29 (n)
  • 91.38 (a)
Samd1 16
Samd1 36
  • 78 (a)
(Pan troglodytes)
Mammalia SAMD1 35
  • 98.53 (n)
  • 98.16 (a)
SAMD1 36
  • 94 (a)
(Rattus norvegicus)
Mammalia LOC102550189 35
  • 85.48 (n)
  • 90.24 (a)
(Monodelphis domestica)
Mammalia SAMD1 36
  • 69 (a)
(Anolis carolinensis)
Reptilia SAMD1 36
  • 87 (a)
(Danio rerio)
Actinopterygii samd1a 36
  • 36 (a)
samd1b 36
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2662 36
  • 12 (a)
Species with no ortholog for SAMD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD1 Gene

Gene Tree for SAMD1 (if available)
Gene Tree for SAMD1 (if available)

Paralogs for SAMD1 Gene

Paralogs for SAMD1 Gene

(4) SIMAP similar genes for SAMD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SAMD1: view

Variants for SAMD1 Gene

Sequence variations from dbSNP and Humsavar for SAMD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_061701 -

Structural Variations from Database of Genomic Variants (DGV) for SAMD1 Gene

Variant ID Type Subtype PubMed ID
dgv3739n71 CNV Loss 21882294
dgv3741n71 CNV Loss 21882294
nsv833761 CNV Loss 17160897
nsv828452 CNV Loss 20364138
nsv828454 CNV Gain 20364138
dgv49n68 CNV Loss 17160897
dgv3744n71 CNV Loss 21882294
nsv911117 CNV Loss 21882294
nsv911119 CNV Loss 21882294
nsv828455 CNV Gain 20364138
esv2677290 CNV Deletion 23128226
esv21807 CNV Loss 19812545

Variation tolerance for SAMD1 Gene

Gene Damage Index Score: 1.99; 36.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SAMD1 Gene

Disorders for SAMD1 Gene

Relevant External Links for SAMD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SAMD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD1 Gene

Publications for SAMD1 Gene

  1. Atherin: a newly identified, lesion-specific, LDL-binding protein in human atherosclerosis. (PMID: 16159594) Lees A.M. … Lees R.S. (Atherosclerosis 2005) 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for SAMD1 Gene

Sources for SAMD1 Gene