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SALL3 Gene

protein-coding   GIFtS: 45
GCID: GC18P076766

Spalt-Like Transcription Factor 3

(Previous names: sal (Drosophila)-like 3, sal-like 3 (Drosophila))
  See SALL3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spalt-Like Transcription Factor 31 2     Sal-Like 3 (Drosophila)1
Zinc Finger Protein 7962 3     C2H2 Zinc Finger Protein SALL32
ZNF7962 3     Sal-Like Protein 32
hSALL32 3     Spalt-Like Zinc Finger Protein2
Sal (Drosophila)-Like 31     Zinc Finger Protein SALL33

External Ids:    HGNC: 105271   Entrez Gene: 271642   Ensembl: ENSG000002564637   OMIM: 6050795   UniProtKB: Q9BXA93   

Export aliases for SALL3 gene to outside databases

Previous GC identifers: GC18U990052 GC18P076475 GC18P074839 GC18P074841 GC18P073383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SALL3 Gene:
This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved
genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes
are associated with congenital disorders in human, suggesting their importance in embryonic development. This
protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It
is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in
oncogenesis. (provided by RefSeq, Oct 2011)

GeneCards Summary for SALL3 Gene:
SALL3 (spalt-like transcription factor 3) is a protein-coding gene. Diseases associated with SALL3 include 18q deletion syndrome. An important paralog of this gene is ZNF236.

UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9
Function: Probable transcription factor

Gene Wiki entry for SALL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SALL3 gene promoter:
         E2F-3a   E2F-4   E2F-5   POU3F2 (N-Oct-5a)   E2F-2   POU3F2   Evi-1   FOXL1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSALL3 promoter sequence
   Search Chromatin IP Primers for SALL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SALL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

SALL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SALL3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P076766:  view genomic region     (about GC identifiers)

Start:
76,740,275 bp from pter      End:
76,762,677 bp from pter
Size:
22,403 bases      Orientation:
plus strand

1 alternative location:
Chr18+,NW_003315961 45,390-63,310     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9 (See protein sequence)
Recommended Name: Sal-like protein 3  
Size: 1300 amino acids; 135346 Da
Developmental stage: In fetal brain of the 24th gestational week
Secondary accessions: Q9UGH1
Alternative splicing: 4 isoforms:  Q9BXA9-1   Q9BXA9-2   Q9BXA9-3   Q9BXA9-4   (Lacks two zinc finger domains. Major isoform with isoform 1)

Explore the universe of human proteins at neXtProt for SALL3: NX_Q9BXA9

Explore proteomics data for SALL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1198
  • Modification sites at PhosphoSitePlus

  • See SALL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_741996.2  
    ENSEMBL proteins: 
     ENSP00000441823   ENSP00000458360   ENSP00000439975   ENSP00000461451  

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    Cloud-Clone Corp. Proteins for SALL3

     
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    antibodies-online peptides for SALL3

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    antibodies-online antibodies for SALL3 (2 products) 

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    antibodies-online kits for SALL3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BXA9

    ProtoNet protein and cluster: Q9BXA9

    UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9
    Similarity: Belongs to the sal C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    Find genes that share domains with SALL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SALL3_HUMAN, Q9BXA9
    Function: Probable transcription factor

         Genatlas biochemistry entry for SALL3:
    spalt (sal)-like,Drosophila SAL like gene 3,expressed in fetal brain and in several adult
    tissues,haploinsufficency in the 18q deletion syndrome and may be contributing to the phenotype

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with SALL3           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sall3):
     behavior/neurological  craniofacial  digestive/alimentary  homeostasis/metabolism  mortality/aging 
     nervous system  respiratory system  skeleton 

    Find genes that share phenotypes with SALL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sall3tm1Apm for SALL3

       genOway: Develop your customized and physiologically relevant rodent model for SALL3

    miRNA
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    miRTarBase miRNAs that target SALL3:
    hsa-mir-615-3p (MIRT040159)

    Block miRNA regulation of human, mouse, rat SALL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SALL3 (see all 10):
    hsa-miR-187* hsa-miR-1283 hsa-miR-409-3p hsa-miR-3660 hsa-let-7a-2* hsa-miR-132 hsa-miR-888* hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidSALL3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SALL3
    Predesigned siRNA for gene silencing in human, mouse, rat SALL3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SALL3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SALL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SALL3_HUMAN, Q9BXA9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SALL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SALL3
    Interactions:

        Search GeneGlobe Interaction Network for SALL3

    Selected Interacting proteins for SALL3 (Q9BXA93) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0021891olfactory bulb interneuron development IEA--
    GO:0035136forelimb morphogenesis IEA--
    GO:0035137hindlimb morphogenesis IEA--

    Find genes that share ontologies with SALL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SALL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SALL3 gene: 
    NM_171999.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537592 ENST00000575389(uc002lmt.3 uc010dra.3) ENST00000572928
    ENST00000536229 ENST00000573324
    miRNA
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    Block miRNA regulation of human, mouse, rat SALL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SALL3 (see all 10):
    hsa-miR-187* hsa-miR-1283 hsa-miR-409-3p hsa-miR-3660 hsa-let-7a-2* hsa-miR-132 hsa-miR-888* hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidSALL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SALL3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SALL3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SALL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SALL3
      QuantiTect SYBR Green Assays in human, mouse, rat SALL3
      QuantiFast Probe-based Assays in human, mouse, rat SALL3

    Selected AceView cDNA sequences (see all 26):

    AI871434 AI637836 AA649850 AI656975 AI480087 AI634411 BE220771 AW137217 
    NM_171999 BF739956 BF432623 BE501147 AW450071 AI668981 AW027492 AA429109 
    T07317 R42871 AI015631 AI475090 AI949558 R37086 R21486 H92108 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SALL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTCGTGT
    SALL3 Expression
    About this image


    SALL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    SALL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SALL3 Protein Expression

    UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9
    Tissue specificity: Widely expressed in adult with highest levels in heart. Expressed in fetal brain (in neurons
    of hippocampus, cortex, mediodorsal and ventrolateral thalamic nuclei, putamen, cerebellum and brainstem)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SALL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SALL3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sall31 , 5 sal-like 3 (Drosophila)1, 5 79(n)1
    81.86(a)1
      18 (54.11 cM)5
    206891  NM_178280.31  NP_840064.21 
     809663765 
    chicken
    (Gallus gallus)
    Aves SALL31 sal-like 3 (Drosophila) 71.51(n)
    77.61(a)
      395359  NM_204647.1  NP_989978.1 
    lizard
    (Anolis carolinensis)
    Reptilia SALL36
    spalt-like transcription factor 3
    74(a)
    1 ↔ 1
    4(52244052-52268338)
    African clawed frog
    (Xenopus laevis)
    Amphibia sal1-A2 zinc finger protein (Xsal-1), homolog of the region more 72.4(n)    L46583.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5607751 sal-like protein 3-like 65.3(n)
    69.01(a)
      560775  XM_684172.6  XP_689264.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta salr6
    salm6
    spalt major
    27(a)
    26(a)
    many ↔ many
    many ↔ many
    2L(11358873-11373637)
    2L(11434311-11445603)
    worm
    (Caenorhabditis elegans)
    Secernentea sem-46
    Protein SEM-4 (sem-4) mRNA, complete cds
    30(a)
    1 → many
    I(7038900-7048834) WBGene00004773
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FZF16
    Transcription factor involved in sulfite metabolis...
    27(a)
    1 → many
    VII(22304-23203) YGL254W


    ENSEMBL Gene Tree for SALL3 (if available)
    TreeFam Gene Tree for SALL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SALL3 gene
    ZNF2362  SALL22  SALL12  SALL42  
    Selected SIMAP similar genes for SALL3 using alignment to 3 protein entries:     SALL3_HUMAN (see all proteins) (see all similar genes):
    ZNF426    ZNF700    HZF16    ZNF791    SALL1    DKFZp434J0650
    ZFS-5    ZFS-4    ZNF844    PLAGL1    ZNF    OVOL3
    ZNF78L1    kr-znf3    DKFZp547H249    ZNF410    ZNF468    SALL4

    Find genes that share paralogs with SALL3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SALL3
    PGOHUM00000259133


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SALL3 (see all 478)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355524
    A colorectal cancer sample4--see VAR_0355522 R H mis40--------
    rs1811539321,2
    --76741257(+) ACCTCA/GGCCGG 1 -- int10--------
    rs1498287501,2
    --76741414(+) TGATTA/GACCTG 1 -- int10--------
    rs29814231,2
    C,F,A,H--76741423(+) TGTTAT/CAAGTT 2 -- int118Minor allele frequency- C:0.08NS EA NA WA 2222
    rs801200811,2
    F--76741672(+) AGCCAA/GGTCAG 1 -- int11Minor allele frequency- G:0.02WA 118
    rs2019902501,2
    --76741767(+) ATGGA-/TTTTTT 2 -- int10--------
    rs16136631,2
    H--76741781(+) TGTTTT/GGTTTA 2 -- int14Minor allele frequency- G:0.00NS EA 398
    rs1856546621,2
    --76741859(+) GAATGA/GATTTA 1 -- int10--------
    rs1887529411,2
    --76742079(+) TAATAA/GAGTAA 1 -- int10--------
    rs1490019281,2
    --76742088(+) AAACCC/TCCTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SALL3 (76740275 - 76762677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SALL3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666555CNV Deletion23128226
    esv2717497CNV Deletion23290073
    nsv2377CNV Insertion18451855
    nsv458313CNV Loss19166990
    dgv3478n71CNV Loss21882294
    dgv3479n71CNV Loss21882294
    dgv3480n71CNV Loss21882294
    nsv828333CNV Loss20364138
    esv29012CNV Loss19812545
    nsv828338CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SALL3
    DNA2.0 Custom Variant and Variant Library Synthesis for SALL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605079    OMIM disorders: --

    1 disease for SALL3:    
    About MalaCards
    18q deletion syndrome


    Find genes that share disorders with SALL3           About GenesLikeMe

    Genetic Association Database (GAD): SALL3
    Human Genome Epidemiology (HuGE) Navigator: SALL3 (1 document)

    Export disorders for SALL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SALL3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SALL3)
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    1. SALL3, a new member of the human spalt-like gene family, maps to 18q23. (PubMed id 10610715)1, 2, 3 Kohlhase J.... Engel W. (Genomics 1999)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. (PubMed id 18668548)1, 4 JuliA A....Marsal S. (Arthritis Rheum. 2008)
    4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    5. Aberrant methylation and downregulation of sall3 in human hepatocellular carcinoma. (PubMed id 22690083)1 Yang X.X....Li M. (World J. Gastroenterol. 2012)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. (PubMed id 21532573)1 Engelen E....Poot R.A. (Nat. Genet. 2011)
    10. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27164 HGNC: 10527 AceView: SALL3 Ensembl:ENSG00000256463 euGenes: HUgn27164
    ECgene: SALL3 H-InvDB: SALL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SALL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SALL3 gene:
    Search GeneIP for patents involving SALL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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