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Aliases for SALL3 Gene

Aliases for SALL3 Gene

  • Spalt-Like Transcription Factor 3 2 3
  • Zinc Finger Protein 796 3 4
  • ZNF796 3 4
  • HSALL3 3 4
  • C2H2 Zinc Finger Protein SALL3 3
  • Spalt-Like Zinc Finger Protein 3
  • Zinc Finger Protein SALL3 4
  • Sal (Drosophila)-Like 3 2
  • Sal-Like 3 (Drosophila) 2

External Ids for SALL3 Gene

Previous GeneCards Identifiers for SALL3 Gene

  • GC18U990052
  • GC18P076766
  • GC18P076475
  • GC18P074839
  • GC18P074841
  • GC18P073383

Summaries for SALL3 Gene

Entrez Gene Summary for SALL3 Gene

  • This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

GeneCards Summary for SALL3 Gene

SALL3 (Spalt-Like Transcription Factor 3) is a Protein Coding gene. Diseases associated with SALL3 include 18q deletion syndrome. An important paralog of this gene is SALL4.

UniProtKB/Swiss-Prot for SALL3 Gene

  • Probable transcription factor

Gene Wiki entry for SALL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SALL3 Gene

Genomics for SALL3 Gene

Regulatory Elements for SALL3 Gene

Genomic Location for SALL3 Gene

Chromosome:
18
Start:
78,980,275 bp from pter
End:
79,002,677 bp from pter
Size:
22,403 bases
Orientation:
Plus strand

Genomic View for SALL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SALL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SALL3 Gene

Proteins for SALL3 Gene

  • Protein details for SALL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXA9-SALL3_HUMAN
    Recommended name:
    Sal-like protein 3
    Protein Accession:
    Q9BXA9
    Secondary Accessions:
    • Q9UGH1

    Protein attributes for SALL3 Gene

    Size:
    1300 amino acids
    Molecular mass:
    135346 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SALL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SALL3 Gene

Proteomics data for SALL3 Gene at MOPED

Post-translational modifications for SALL3 Gene

  • Ubiquitination at Lys 1198
  • Modification sites at PhosphoSitePlus

Other Protein References for SALL3 Gene

No data available for DME Specific Peptides for SALL3 Gene

Domains & Families for SALL3 Gene

Gene Families for SALL3 Gene

Protein Domains for SALL3 Gene

Suggested Antigen Peptide Sequences for SALL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXA9

UniProtKB/Swiss-Prot:

SALL3_HUMAN :
  • Belongs to the sal C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Family:
  • Belongs to the sal C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SALL3: view

Function for SALL3 Gene

Molecular function for SALL3 Gene

GENATLAS Biochemistry:
spalt (sal)-like,Drosophila SAL like gene 3,expressed in fetal brain and in several adult tissues,haploinsufficency in the 18q deletion syndrome and may be contributing to the phenotype
UniProtKB/Swiss-Prot Function:
Probable transcription factor

Gene Ontology (GO) - Molecular Function for SALL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with SALL3: view
genes like me logo Genes that share phenotypes with SALL3: view

Animal Models for SALL3 Gene

MGI Knock Outs for SALL3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SALL3 Gene

Localization for SALL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SALL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SALL3 Gene COMPARTMENTS Subcellular localization image for SALL3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SALL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SALL3: view

Pathways & Interactions for SALL3 Gene

SuperPathways for SALL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SALL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007165 signal transduction IBA --
GO:0021891 olfactory bulb interneuron development IEA --
genes like me logo Genes that share ontologies with SALL3: view

No data available for Pathways by source and SIGNOR curated interactions for SALL3 Gene

Drugs & Compounds for SALL3 Gene

No Compound Related Data Available

Transcripts for SALL3 Gene

mRNA/cDNA for SALL3 Gene

Unigene Clusters for SALL3 Gene

Sal-like 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SALL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SALL3 Gene

No ASD Table

Relevant External Links for SALL3 Gene

GeneLoc Exon Structure for
SALL3
ECgene alternative splicing isoforms for
SALL3

Expression for SALL3 Gene

mRNA expression in normal human tissues for SALL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SALL3 Gene

This gene is overexpressed in Vagina (x6.1), Brain - Spinal cord (cervical c-1) (x5.5), Brain - Caudate (basal ganglia) (x4.4), Brain - Amygdala (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SALL3 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SALL3 Gene



SOURCE GeneReport for Unigene cluster for SALL3 Gene Hs.700557

mRNA Expression by UniProt/SwissProt for SALL3 Gene

Q9BXA9-SALL3_HUMAN
Tissue specificity: Widely expressed in adult with highest levels in heart. Expressed in fetal brain (in neurons of hippocampus, cortex, mediodorsal and ventrolateral thalamic nuclei, putamen, cerebellum and brainstem)
genes like me logo Genes that share expression patterns with SALL3: view

Protein tissue co-expression partners for SALL3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for SALL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SALL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SALL3 35
  • 83.16 (n)
  • 83.55 (a)
mouse
(Mus musculus)
Mammalia Sall3 35
  • 79 (n)
  • 81.86 (a)
Sall3 16
Sall3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SALL3 35
  • 98.4 (n)
  • 98.61 (a)
SALL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sall3 35
  • 80.99 (n)
  • 85.5 (a)
dog
(Canis familiaris)
Mammalia SALL3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SALL3 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SALL3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SALL3 35
  • 71.51 (n)
  • 77.61 (a)
SALL3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SALL3 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sall3 35
  • 65.82 (n)
  • 73.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia sal1-A 35
zebrafish
(Danio rerio)
Actinopterygii LOC560775 35
  • 65.3 (n)
  • 69.01 (a)
sall3a 36
  • 56 (a)
OneToMany
sall3b 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta salm 36
  • 26 (a)
ManyToMany
salr 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sem-4 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FZF1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for SALL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SALL3 Gene

ENSEMBL:
Gene Tree for SALL3 (if available)
TreeFam:
Gene Tree for SALL3 (if available)

Paralogs for SALL3 Gene

Paralogs for SALL3 Gene

Pseudogenes.org Pseudogenes for SALL3 Gene

genes like me logo Genes that share paralogs with SALL3: view

Variants for SALL3 Gene

Sequence variations from dbSNP and Humsavar for SALL3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs267605261 untested 78,993,131(+) AGCAT(C/T)GCGGC reference, synonymous-codon
VAR_014132 -
VAR_035552 A colorectal cancer sample
VAR_059887 -

Structural Variations from Database of Genomic Variants (DGV) for SALL3 Gene

Variant ID Type Subtype PubMed ID
esv2717497 CNV Deletion 23290073
dgv3478n71 CNV Loss 21882294
dgv3479n71 CNV Loss 21882294
nsv458313 CNV Loss 19166990
dgv564n67 CNV Gain 20364138
nsv828333 CNV Loss 20364138
dgv3480n71 CNV Loss 21882294
nsv828338 CNV Gain 20364138
dgv565n67 CNV Gain 20364138
nsv828342 CNV Gain 20364138
esv2666555 CNV Deletion 23128226
esv29012 CNV Loss 19812545
nsv2377 CNV Insertion 18451855

Variation tolerance for SALL3 Gene

Residual Variation Intolerance Score: 37.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SALL3 Gene

HapMap Linkage Disequilibrium report
SALL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SALL3 Gene

Disorders for SALL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SALL3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
18q deletion syndrome
  • chromosome 18q deletion syndrome
- elite association
Search SALL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SALL3

Genetic Association Database (GAD)
SALL3
Human Genome Epidemiology (HuGE) Navigator
SALL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SALL3
genes like me logo Genes that share disorders with SALL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SALL3 Gene

Publications for SALL3 Gene

  1. SALL3, a new member of the human spalt-like gene family, maps to 18q23. (PMID: 10610715) Kohlhase J. … Engel W. (Genomics 1999) 2 67
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 67
  3. Aberrant methylation and downregulation of sall3 in human hepatocellular carcinoma. (PMID: 22690083) Yang X.X. … Li M. (World J. Gastroenterol. 2012) 67
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for SALL3 Gene

Sources for SALL3 Gene

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