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SALL2 Gene

protein-coding   GIFtS: 57

GC14M021059
sal-like 2 (Drosophila)
(Previous name: sal (Drosophila)-like 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ10414 2
FLJ55746 2
HSAL2 2, 5
HSal2 3
Hsal2 1
KIAA0360 1, 2, 3
SAL2 3
ZNF795 1, 2
p150(Sal2) 2
Descriptions
Zinc finger protein SALL2 3
sal (Drosophila)-like 2 1
sal-like 2 2
sal-like 2 (Drosophila) 2
External Ids
HGNC: 105261
Entrez Gene: 62972
UniProtKB: Q9Y4673
Ensembl: ENSG000001658217
Search outside databases for aliases for SALL2 gene

Previous GC identifers: GC14M019361 GC14M015776 GC14M019979 GC14M019980 GC14U900549

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
Function: Probable transcription factor

Gene Wiki entry for SALL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SALL2 gene  

Entrez Gene cytogenetic band: 14q11.1-q12   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1-q12.1

SALL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021059:     (about GC identifiers)

Start:
21,059,071 bp from pter
End:
21,075,177 bp from pter
Size:
16,107 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467 (See protein sequence)
Recommended Name: Sal-like protein 2  
Size: 1007 amino acids; 105399 Da
Subcellular location: Nucleus (Probable)
Developmental stage: In fetal brain exclusively in pontine nuclei
Secondary accessions: B2RMX6 Q9Y4G1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005398.1  

    ENSEMBL proteins: 
    ENSP00000333537 ENSP00000320536 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SALL2)
    Human Recombinant Proteins from Abnova (SALL2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus NAS--
    About this table

    Antibodies for SALL2: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of SALL2
    Sigma-Aldrich Antibodies for SALL2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SALL2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SALL2)
    Novus Biologicals Antibodies for SALL2

    Assays for SALL2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2


       GeneDecks  SALL2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y467

    ProtoNet protein and cluster: Q9Y467

    UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
    Similarity: Belongs to the sal C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SALL2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SALL2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC024245

                  Applied Biosystems Silencer® siRNAs for SALL2

                  Sigma-Aldrich siRNA for SALL2  
                         Sigma-Aldrich shRNA for SALL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SALL2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005407
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005407
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_005407 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005407

    UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
    Function: Probable transcription factor

    Genatlas biochemistry entry for SALL2:
    brain specific transcription factor,Drosophila homeotic gene Sal-like 2,expressed in different
    brain areas

    4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sall2):

    lethality-prenatal/perinatalnervous systemnormalrenal/urinary system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity NAS--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  SALL2 


    1 Interacting protein for SALL2 (Q9Y4672) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NGFRP081382MINT-7012365 MINT-7012311 MINT-7012345
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SALL2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SALL2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SALL2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC024245

                  Sigma-Aldrich siRNA for SALL2  
                         Sigma-Aldrich shRNA for SALL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005407  

    REFSEQ mRNAs for SALL2 gene: 

    NM_005407.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005407  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005407
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005407
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_005407 

    Additional cDNA sequence: 

    AB002358.2 AF465630.1 AK001276.1 AK294051.1 AK299931.1 BC136528.1 BC136529.1 CR614081.1 
    X98834.1 

    9 DOTS entries:

    DT.87013253  DT.92422658  DT.100755383  DT.100755384  DT.102823693  DT.100645217  DT.100664725  DT.100755386 
    DT.75102282 

    highest scoring ESTs for SALL2:

    AB002358 BI549867 CN399015 CN399023 CN399024 CN399027 CN399028 CN399032 X98834 AA211861 

    Unigene Clusters for SALL2:

    Sal-like 2 (Drosophila)
    Hs.416358  [show with all ESTs], Hs.719293  [show with all ESTs]
    Unigene Representative Sequences: AK296414, NM_005407


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SALL2 (see all 6 )

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
    SP1:                                      -     -                     
    SP2:                                      -     -     -               
    SP3:              -     -                 -     -     -               
    SP4:                                                                  
    SP5:        -     -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for SALL2

    2 Ensembl transcripts including schematic representations:
    ENST00000327430  ENST00000317492  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SALL2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SALL2

    1 / 2 / 3

    3 probe-sets matching SALL2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37567_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X98834 0.60 1.00 0.82 1

    213283_s_at2, 3 U133-A 1 1.00 1.00 -- -- BG285616 0.20 1.00 0.72 1

    213283_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SALL2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.416358 Hs.719293

    Expression variation in blood from EXPOLDB for SALL2

    UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
    Tissue specificity: Highest levels in adult brain (in different areas). Lower levels in heart; very
    low levels in kidney and pancreas

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SALL2 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    SALL21   -- sal-like 2 (Drosophila) 99.64(n)
    99.21(a)
    452766  XM_001154944.1  XP_001154944.1 
    cow
    (Bos taurus)
    SALL21   -- sal-like 2 (Drosophila) 87.95(n)
    92.28(a)
    527574  XM_605967.3  XP_605967.3 
    rat
    (Rattus norvegicus)
    Sall21   -- sal-like 2 (Drosophila) 86.99(n)
    90.44(a)
    305854  XM_223992.4  XP_223992.4 
    mouse
    (Mus musculus)
    Sall21, 5 145
    sal-like 2 (Drosophila)1, 5 87.22(n)1
    90.64(a)1
    505241  NM_015772.21  NP_056587.21 
     AB0932335  AI2258095  (see all 14)
    fruit fly
    (Drosophila melanogaster)
    salm3 2 32F1--2 oenocyte development specific RNA
    polymerase II more
    59(a)   --
    About this table        Species with no ortholog for SALL2

    ENSEMBL Gene Tree for SALL2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SALL2 gene
    ZNF2362  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/115 NCBI SNPs in SALL2 are shown (see all 115 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 54)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs12638101,2
    A,C,F,H,O21061466(+) ACTCCC/GTGCCC 1 G/R mis1 ese311Minor allele frequency- G:0.35MN NA EA EU WA 1718
    rs12638091,2
    A,C,F,H21058740(+) AAGACT/GGAAAA 1 -- ng518Minor allele frequency- G:0.20EU EA WA 810
    rs7123221,2
    C,F,H,O21059681(+) CAAAAA/GTGCTC 1 -- ut3123Minor allele frequency- G:0.10NA EA NS EU WA 1736
    rs11249811,2
    A,C,F21060377(+) GAGGAG/AAGAGG 1 -- ut31 ese3 trp32Minor allele frequency- A:0.28MN EA 930
    rs31779541,2
    C,F,H21059669(-) TCAGCA/GTGGTT 1 -- ut31 ese316Minor allele frequency- G:0.25NA EU EA WA 1464
    rs22425271,2
    C,F,H21063478(+) CCGAAG/CAGTTG 1 C/S mis113Minor allele frequency- C:0.12EA EU WA 2736
    rs12638111,2
    C,F,H21063338(+) CCCTGA/GAGACT 1 P/S mis1 ese316Minor allele frequency- G:0.26MN NA EA EU WA 2922
    rs116210901,2
    C,H21061120(+) TGCCTC/GCTAAA 1 G/A mis14Minor allele frequency- G:0.00EU EA WA 416
    rs7417071,2
    H21060021(-) GCACCC/TAAGGC 1 -- ut31 ese38Minor allele frequency- T:0.00NA EA MN EU WA 856
    rs31779521,2
    H21060189(-) AATGGC/GCTGCC 1 -- ut314Minor allele frequency- G:0.00EU EA WA 406
    About this table

    HapMap Linkage Disequilibrium images for SALL2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602219

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/16 PubMed articles for SALL2 gene (see all 16 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6297 HGNC: 10526 Ensembl:ENSG00000165821 euGenes: HUgn6297 ECgene: SALL2
    H-InvDB: SALL2
    (According to HUGE)
    About This Section

    HUGE: KIAA0360
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SALL2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for SALL2 Antibodies for SALL2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SALL2 Browse small molecules at Sigma-Aldrich
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