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SALL2 Gene

protein-coding   GIFtS: 57
GCID: GC14M021989

Spalt-Like Transcription Factor 2

(Previous names: sal (Drosophila)-like 2, sal-like 2 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spalt-Like Transcription Factor 21 2     Sal (Drosophila)-Like 21
Zinc Finger Protein 7952 3     Sal-Like 2 (Drosophila)1
Zinc Finger Protein SALL22 3     p150(Sal2)2
Zinc Finger Protein Spalt-22 3     Sal-Like Protein 22
Sal-22 3     KIAA03603
ZNF7952 3     SAL23
HSAL22 5     hSal23

External Ids:    HGNC: 105261   Entrez Gene: 62972   Ensembl: ENSG000001658217   OMIM: 6022195   UniProtKB: Q9Y4673   

Export aliases for SALL2 gene to outside databases

Previous GC identifers: GC14M019361 GC14M015776 GC14M019979 GC14M019980 GC14M021059 GC14U900549 GC14M002107


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SALL2 Gene:
SALL2 (spalt-like transcription factor 2) is a protein-coding gene. Diseases associated with SALL2 include synovial sarcoma, and sarcoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SALL3.

UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
Function: Probable transcription factor

Gene Wiki entry for SALL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SALL2 gene promoter:
         GR   AML1a   RREB-1   MyoD   NF-kappaB   AREB6   NF-kappaB2   GR-alpha   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SALL2 promoter sequence
   Search Chromatin IP Primers for SALL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SALL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1-q12   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1-q12.1

SALL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SALL2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021989:  view genomic region     (about GC identifiers)

Start:
21,989,231 bp from pter      End:
22,005,350 bp from pter
Size:
16,120 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467 (See protein sequence)
Recommended Name: Sal-like protein 2  
Size: 1007 amino acids; 105309 Da
Developmental stage: In fetal brain exclusively in pontine nuclei
Sequence caution: Sequence=BAA21638.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RMX6 B9EGK8 Q9Y4G1

Explore the universe of human proteins at neXtProt for SALL2: NX_Q9Y467

Explore proteomics data for SALL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys911
  • Modification sites at PhosphoSitePlus

  • See SALL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005398.1  
    ENSEMBL proteins: 
     ENSP00000333537   ENSP00000320536   ENSP00000445916   ENSP00000440054   ENSP00000396773  
     ENSP00000438493   ENSP00000439654  

    SALL2 Human Recombinant Protein Products:

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    Novus Biologicals SALL2 Protein
    Novus Biologicals SALL2 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SALL2

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    Abcam antibodies for SALL2
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    LSBio Antibodies in human, mouse, rat for SALL2

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    Cloud-Clone Corp. CLIAs for SALL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y467

    ProtoNet protein and cluster: Q9Y467

    UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
    Similarity: Belongs to the sal C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    SALL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SALL2_HUMAN, Q9Y467
    Function: Probable transcription factor

         Genatlas biochemistry entry for SALL2:
    brain specific transcription factor,Drosophila homeotic gene Sal-like 2,expressed in different brain areas

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI19131967
    GO:0046872metal ion binding IEA--
         
    SALL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SALL2:
     Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sall2):
     embryogenesis  mortality/aging  nervous system  normal  renal/urinary system 

    SALL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SALL2: Sall2tm1Jkoh Sall2tm1Ryn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SALL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SALL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SALL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SALL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SALL2:
    hsa-mir-99a-5p (MIRT048695), hsa-mir-106b-3p (MIRT038599), hsa-mir-615-3p (MIRT039723), hsa-mir-484 (MIRT042308), hsa-let-7b-5p (MIRT052046), hsa-mir-331-3p (MIRT043322)

    Block miRNA regulation of human, mouse, rat SALL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SALL2 (see all 17):
    hsa-miR-320a hsa-miR-3194-5p hsa-miR-764 hsa-miR-23a hsa-miR-31 hsa-miR-1237 hsa-miR-130a* hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmidSALL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SALL2
    Predesigned siRNA for gene silencing in human, mouse, rat SALL2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SALL2

    Clone
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    OriGene clones in human, mouse for SALL2 (see all 8)
    OriGene ORF clones in mouse, rat for SALL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SALL2 (NM_005407)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SALL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SALL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SALL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SALL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SALL2_HUMAN, Q9Y467: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016581NuRD complex IEA--

    SALL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SALL2
    Interactions:

        GeneGlobe Interaction Network for SALL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SALL2 (Q9Y4671, 2, 3 ENSP000003335374) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NGFRP081381, 2, 3, ENSP000001722294EBI-8541433,EBI-1387782 MINT-7012365 MINT-7012311 MINT-7012345 I2D: score=2 STRING: ENSP00000172229
    SALL4Q9UJQ43, ENSP000002170864I2D: score=1 STRING: ENSP00000217086
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ZMIZ2Q8NF643, ENSP000003117784I2D: score=3 STRING: ENSP00000311778
    CEP76Q8TAP63, ENSP000002621274I2D: score=3 STRING: ENSP00000262127
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0021915neural tube development IEA--
    GO:0045892negative regulation of transcription, DNA-templated ----

    SALL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SALL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SALL2 gene: 
    NM_005407.1  

    Unigene Cluster for SALL2:

    Sal-like 2 (Drosophila)
    Hs.416358  [show with all ESTs]
    Unigene Representative Sequence: NM_005407
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327430(uc010tly.2 uc010tlz.1 uc001wbe.3 uc010tma.1 uc001wbg.1)
    ENST00000317492(uc001wbf.3) ENST00000538754 ENST00000546363 ENST00000450879
    ENST00000537235 ENST00000541965
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SALL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SALL2 (see all 17):
    hsa-miR-320a hsa-miR-3194-5p hsa-miR-764 hsa-miR-23a hsa-miR-31 hsa-miR-1237 hsa-miR-130a* hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmidSALL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SALL2
    Predesigned siRNA for gene silencing in human, mouse, rat SALL2
    Clone
    Products:
         
    OriGene clones in human, mouse for SALL2 (see all 8)
    OriGene ORF clones in mouse, rat for SALL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SALL2 (NM_005407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SALL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SALL2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SALL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SALL2
      QuantiTect SYBR Green Assays in human, mouse, rat SALL2
      QuantiFast Probe-based Assays in human, mouse, rat SALL2

    Additional mRNA sequence: 

    AB002358.2 AF465630.1 AK001276.1 AK294051.1 AK299931.1 BC136528.1 BC136529.1 X98834.1 

    9 DOTS entries:

    DT.87013253  DT.100755383  DT.92422658  DT.102823693  DT.100755384  DT.100645217  DT.100664725  DT.100755386 
    DT.75102282 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SALL2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
    SP1:                                      -     -                     
    SP2:                                      -     -     -               
    SP3:              -     -                 -     -     -               
    SP4:                                                                  
    SP5:        -     -     -                                             


    ECgene alternative splicing isoforms for SALL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SALL2 expression in normal human tissues (normalized intensities)      SALL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGATTTCC
    SALL2 Expression
    About this image


    SALL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             Line H1 (WA01)
             ESI-051   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)
    SALL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SALL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416358

    UniProtKB/Swiss-Prot: SALL2_HUMAN, Q9Y467
    Tissue specificity: Highest levels in adult brain (in different areas). Lower levels in heart; very low levels in
    kidney and pancreas

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    QuantiFast Probe-based Assays in human, mouse, rat SALL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SALL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SALL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sall21 , 5 sal-like 2 (Drosophila)1, 5 85.96(n)1
    88.55(a)1
      14 (26.89 cM)5
    505241  NM_015772.31  NP_056587.21 
     523111725 
    lizard
    (Anolis carolinensis)
    Reptilia SALL26
    spalt-like transcription factor 2
    60(a)
    1 ↔ 1
    AAWZ02041297(1011-3365)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sall21 spalt-like transcription factor 2 58.76(n)
    61.24(a)
      100038135  XM_004910748.1  XP_004910805.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SALL26
    spalt-like transcription factor 2
    23(a)
    1 ↔ 1
    2(37850519-37859580) ENSDARG00000075116
    fruit fly
    (Drosophila melanogaster)
    Insecta salm3 oenocyte development specific RNA
    polymerase II more
    59(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea sem-46
    Protein SEM-4 (sem-4) mRNA, complete cds
    15(a)
    1 → many
    I(7038900-7048834) WBGene00004773
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FZF16
    Transcription factor involved in sulfite metabolis...
    16(a)
    1 → many
    VII(22304-23203) YGL254W


    ENSEMBL Gene Tree for SALL2 (if available)
    TreeFam Gene Tree for SALL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SALL2 gene
    SALL32  ZNF2362  SALL12  SALL42  
    Selected SIMAP similar genes for SALL2 using alignment to 7 protein entries:     SALL2_HUMAN (see all proteins) (see all similar genes):
    DKFZp434J0650    HZF16    OVOL3    ZFS-5    ZNFN1A2    ZNF791
    ZNF844    PLZF    DKFZp686N0199    KLF1    KLF4    ZNF808
    ZNF    KLF13    PLAGL1    ZNF410    ZNF78L1    ZNF219

    SALL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SALL2 (see all 483)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912430351,2
    --21988791(+) TACATG/TTTTTT 1 -- ds50010--------
    rs12638091,2
    C,F,A,H--21988900(+) AAGACT/GGAAAA 1 -- ds500124Minor allele frequency- G:0.26NS EA NA WA CSA 2766
    rs1145872081,2
    F--21989052(+) CCACAG/AAGAAG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1461402381,2
    --21989186(+) CACACC/TCCAGC 1 -- ds50010--------
    rs775442661,2
    C--21989210(+) ATGAAA/GTAAGG 1 -- ds50010--------
    rs1489053861,2
    --21989220(+) GAGAAA/GCACAT 1 -- ds50010--------
    rs1129772831,2
    C,F--21989324(+) GCCTAC/GAGCTT 1 -- ut312Minor allele frequency- G:0.04CSA WA 120
    rs1827978311,2
    --21989369(+) AAACCC/TTCACT 1 -- ut310--------
    rs1389034241,2
    C--21989472(+) TGGAG-/CTGGTC
    TCCCAAAGT
    CTGGG
    1 -- cds10--------
    rs756789361,2
    C--21989476(+) GCTGG-/TCTCCC
    AAAGTCTGG
    GACTC
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for SALL2 (21989231 - 22005350 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SALL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660046CNV Deletion23128226
    esv2422459CNV Duplication17116639
    nsv522850CNV Gain19592680

    Human Gene Mutation Database (HGMD): SALL2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602219    OMIM disorders: --

    2 diseases for SALL2:    About MalaCards
    synovial sarcoma    sarcoma


    SALL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SALL2
    Human Genome Epidemiology (HuGE) Navigator: SALL2 (3 documents)

    Export disorders for SALL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SALL2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with SALL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt. (PubMed id 8975705)1, 2, 3 Kohlhase J.... Stick R. (Genomics 1996)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F.... Peng X. (Proteomics 2008)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    6. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. (PubMed id 14507652)1, 9 Nielsen T.O....van de Rijn M. (Am. J. Pathol. 2003)
    7. Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers. (PubMed id 23273547)1 Sung C.K....Benjamin T. (Mol Oncol 2013)
    8. The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. (PubMed id 23029531)1 Sung C.K....Benjamin T. (PLoS ONE 2012)
    9. Human papillomavirus type 16 E6 inhibits p21(WAF1) transcription independently of p53 by inactivating p150(Sal2). (PubMed id 21791360)1 Parroche P....Tommasino M. (Virology 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6297 HGNC: 10526 Ensembl:ENSG00000165821 euGenes: HUgn6297 ECgene: SALL2
    H-InvDB: SALL2

    (According to HUGE)
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    HUGE: KIAA0360

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SALL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SALL2 gene:
    Search GeneIP for patents involving SALL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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