SAGE1 Gene
protein-coding GIFtS: 46
GCID: GC0XP134971
|
|
sarcoma antigen 1
| |
Aliases
for SAGE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sarcoma Antigen 11 2 | | SAGE1 2 3 5 | | CT141 2 3 | | Cancer/Testis Antigen 142 3 | | Putative Tumor Antigen2 |
Export aliases for SAGE1 gene to outside databasesPrevious GC identifers: GC0XP133682 GC0XP134701 GC0XP134803 GC0XP124250 |
Summaries
for SAGE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SAGE1:
This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of differenthistologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteinsencoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancerimmunotherapy. This gene is expressed in sarcomas. (provided by RefSeq, Jul 2008)
|
Genomic Views
for SAGE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SAGE1 gene promoter:
SRF MEF-2 SRF (504 AA) HNF-1A MEF-2A N-Myc PPAR-gamma1 HNF-1 PPAR-gamma2 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SAGE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAGE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26SAGE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP134971: view genomic region
(about GC identifiers)
Start:
|
134,971,374 bp from pter |
End:
|
134,995,220 bp from pter |
Size:
|
23,847 bases |
Orientation:
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plus strand |
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Proteins
for SAGE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAGE1_HUMAN, Q9NXZ1 (See
protein sequence)Recommended Name: Sarcoma antigen 1 Size: 904 amino acids; 99225 Da
Secondary accessions: Q5JNW0Explore the universe of human proteins at neXtProt for SAGE1: NX_Q9NXZ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXZ1
SAGE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061136.2
ENSEMBL proteins: ENSP00000359743 ENSP00000323191 ENSP00000445959 ENSP00000438276
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SAGE1 for ontologies About GeneDecksing
SAGE1 Antibody Products:
Assay Products for SAGE1: |
Protein
Domains /
Families
for SAGE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NXZ1 |
Function
for SAGE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAGE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAGE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SAGE1 (NM_018666) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAGE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAGE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAGE1 |
|
Pathways & Interactions
for SAGE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAGE1
|
Drugs & Compounds
for SAGE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SAGE1 for compounds About GeneDecksing
 Browse Tocris compounds for SAGE1
1 Novoseek chemical compound relationship for SAGE1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| oligonucleotide |
23.7 |
4 |
16098712 (1), 16041676 (1), 11860305 (1), 19073704 (1) |
Search CenterWatch for drugs/clinical trials and news about SAGE1
|
Transcripts
for SAGE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SAGE1 gene: NM_018666.2 Unigene Cluster for SAGE1: Sarcoma antigen 1 Hs.195292 [show with all ESTs]Unigene Representative Sequence: AK3104124 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370709 ENST00000324447 ENST00000535938(uc004ezh.3 uc011mvv.2 uc010nry.1)
ENST00000537770
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAGE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAGE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SAGE1 (NM_018666) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAGE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAGE1 |
Additional cDNA sequence: AJ278111.1 AK310412.1 BC144260.1 3 DOTS entries: DT.75101167 DT.302879 DT.121309571 8 AceView cDNA sequences: CD358947 BX118393 AW025754 AA608952 AJ278111 NM_018666 AA928800 AI911341
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SAGE1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | |
ECgene alternative splicing isoforms for SAGE1
|
Expression
for SAGE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SAGE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SAGE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAGE1
SOURCE GeneReport for Unigene cluster: Hs.195292
UniProtKB/Swiss-Prot: SAGE1_HUMAN, Q9NXZ1Tissue specificity: Expressed mainly in bladder, lung, head and neck carcinomas. Not expressed in normal tissues exceptfor testis
SABiosciences Custom PCR Arrays for SAGE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SAGE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAGE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAGE1 |
Orthologs
for SAGE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SAGE1 gene from 2/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
IntS66 |
Integrator 6 |
8(a) |
1 → many |
X(5632696-5641287) |
worm
(Caenorhabditis elegans) |
Secernentea |
dic-16 |
-- |
9(a) |
1 → many |
IV(8692086-8696443) |
Species with no ortholog for SAGE1
ENSEMBL Gene Tree for SAGE1 (if available)
TreeFam Gene Tree for SAGE1 (if available) |
Paralogs
for SAGE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SAGE1 gene
- INTS62 CT45A22 CT45A52 CT45A12 CT45A42 CT45A62 DDX26B2 CT45A32
7 SIMAP similar genes for SAGE1 using alignment to 3 protein entries: SAGE1_HUMAN (see all proteins):CT45A1 CT45A4 CT45A6 CT45A2 CT45A3 CT45A5
DDX26B
SAGE1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for SAGE1
PGOHUM00000241562 PGOHUM00000261813 PGOHUM00000260988
|
Genomic Variants
for SAGE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SAGE1 (134971374 - 134995220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SAGE1
4 CNVs: 0826 37003 2281 4174
1 Inversion: 37350
Human Gene Mutation Database (HGMD): SAGE1
Locus Specific Mutation Databases (LSDB): SAGE1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SAGE1 |
|
Disorders
/ Diseases
for SAGE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SAGE1 for disorders About GeneDecksing
OMIM gene information: 300359
OMIM disorders: --
20/27  diseases for SAGE1 (see all 27): About MalaCardssarcoma estrogen-receptor positive breast cancer non-small cell lung carcinoma retroperitoneal fibrosis
papillary renal cell carcinoma barrett's esophagus renal cell carcinoma pancreatic ductal adenocarcinoma
ductal carcinoma in situ lung carcinoma multiple myeloma breast cancer
seminoma carcinoma parkinson's disease myeloma
rhabdomyosarcoma fibrosis colorectal cancer lung cancer
1 disease from the University of Copenhagen DISEASES database for SAGE1:Seminoma 6 Novoseek disease relationships for SAGE1 gene About this table
Export disorders for SAGE1 gene to outside databases
|
Publications
for SAGE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SAGE1 gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with SAGE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification on a human sarcoma of two new genes with tumor- specific expression. (PubMed id 10919659)1, 2, 3, 9 Martelange V.M.F.... Boon T. (2000)
- Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE. (PubMed id 16061876)1, 9 Miyahara Y....Shiku H. (2005)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Technology evaluation: SAGE, Genzyme molecular oncology. (PubMed id 11249736)9 Bartlett J. (2001)
- Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression. (PubMed id 15477757)9 Hustinx S.R....Hruban R.H. (2004)
- A feature selection approach for identification of signature genes from SAGE data. (PubMed id 17519038)9 Barrera J....Brentani H. (2007)
- Pan-genome isolation of low abundance transcripts using SAGE tag. (PubMed id 17113583)9 Kim Y.C....Wang S.M. (2006)
|
External Searches for SAGE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SAGE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SAGE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAGE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SAGE1 gene:
Search GeneIP for patents involving SAGE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SAGE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SAGE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SAGE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SAGE1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SAGE1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAGE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAGE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SAGE1 | | OriGene Custom Protein Services for SAGE1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAGE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SAGE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAGE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAGE1 |
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