Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SAG Gene

protein-coding   GIFtS: 63
GCID: GC02P234260

S-Antigen; Retina And Pineal Gland (Arrestin)

  See SAG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
S-Antigen; Retina And Pineal Gland (Arrestin)1 2     RP472 5
Arrestin 11 2     S-arrestin2
Rod Photoreceptor Arrestin2 3     Retinal S-Antigen (48 KDa Protein)2
48 KDa Protein2 3     Retinal S-Antigen3
S-AG2 3     

External Ids:    HGNC: 105211   Entrez Gene: 62952   Ensembl: ENSG000001305617   OMIM: 1810315   UniProtKB: P105233   

Export aliases for SAG gene to outside databases

Previous GC identifers: GC02P232224 GC02P232898 GC02P234232 GC02P234503 GC02P233998 GC02P233881 GC02P226017 GC02P234234 GC02P234240 GC02P234247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SAG Gene:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of
G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,
neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor
protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the
retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin
is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene
have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SAG Gene:
SAG (S-antigen; retina and pineal gland (arrestin)) is a protein-coding gene. Diseases associated with SAG include eales disease, and oguchi disease 1. GO annotations related to this gene include opsin binding and protein phosphatase inhibitor activity. An important paralog of this gene is ARR3.

UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523
Function: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to
photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of
phosphodiesterase

Gene Wiki entry for SAG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAG gene promoter:
         c-Fos   GR   AP-1   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SAG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

SAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234260:  view genomic region     (about GC identifiers)

Start:
234,216,309 bp from pter      End:
234,255,701 bp from pter
Size:
39,393 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523 (See protein sequence)
Recommended Name: S-arrestin  
Size: 405 amino acids; 45120 Da
Subunit: Monomer. Homodimer. Homotetramer
Miscellaneous: Arrestin binds calcium
Secondary accessions: A0FDN6 Q53SV3 Q99858

Explore the universe of human proteins at neXtProt for SAG: NX_P10523

Explore proteomics data for SAG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000532.2  
    ENSEMBL proteins: 
     ENSP00000408937   ENSP00000386444   ENSP00000409475   ENSP00000404733   ENSP00000392889  
    Reactome Protein details: P10523

    SAG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SAG
    OriGene Protein Over-expression Lysate for SAG
    OriGene MassSpec for SAG
    OriGene Custom Protein Services for SAG
    GenScript Custom Purified and Recombinant Proteins Services for SAG
    Novus Biologicals SAG Protein
    Novus Biologicals SAG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SAG

     
    Search eBioscience for Proteins for SAG 

     
    antibodies-online proteins for SAG (8 products) 

     
    Search antibodies-online for peptides for SAG

    SAG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SAG 
    OriGene Antibodies for SAG
    OriGene Custom Antibody Services for SAG
    Novus Biologicals SAG Antibodies
    Abcam antibodies for SAG
    Cloud-Clone Corp. Antibodies for SAG
    ThermoFisher Antibody for SAG
    antibodies-online antibodies for SAG (44 products) 

    SAG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAG
    Cloud-Clone Corp. CLIAs for SAG
    Search eBioscience for ELISAs for SAG 
    antibodies-online kits for SAG (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 7):
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR014753 Arrestin_N
     IPR000698 Arrestin
     IPR014752 Arrestin_C

    Graphical View of Domain Structure for InterPro Entry P10523

    ProtoNet protein and cluster: P10523

    1 Blocks protein domain: IPB000698 Arrestin

    UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523
    Similarity: Belongs to the arrestin family


    Find genes that share domains with SAG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARRS_HUMAN, P10523
    Function: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to
    photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of
    phosphodiesterase

         Genatlas biochemistry entry for SAG:
    S-antigen (48kDa),Ca2+ binding,P-rhodopsin inhibitory binding protein (arrestin),retina and pineal gland,cofactor
    of rhodopsin kinase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002046opsin binding IEA--
    GO:0004864protein phosphatase inhibitor activity TAS2550422
    GO:0051219phosphoprotein binding IEA--
         
    Find genes that share ontologies with SAG           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sag):
     nervous system  vision/eye 

    Find genes that share phenotypes with SAG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sagtm1Jnc for SAG

       genOway: Develop your customized and physiologically relevant rodent model for SAG

    miRNA
    Products:
        
    miRTarBase miRNAs that target SAG:
    hsa-mir-335-5p (MIRT017146), hsa-mir-148b-3p (MIRT019260)

    Block miRNA regulation of human, mouse, rat SAG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SAG
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SAG
    Predesigned siRNA for gene silencing in human, mouse, rat SAG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAG

    Clone
    Products:
         
    OriGene clones in human, mouse for SAG (see all 6)
    OriGene ORF clones in mouse, rat for SAG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAG (NM_000541)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAG
    Browse ESI BIO Cell Lines and PureStem Progenitors for SAG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    extracellular2
    golgi apparatus2
    nucleus2
    plasma membrane2
    endosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment ----
    GO:0001917photoreceptor inner segment ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SAG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SAG About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    Visual signal transduction- Rods0.51
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    3Signaling by GPCR
    Signal Transduction0.58
    4Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods
    5Neuroscience
    Neuroscience


    Find genes that share SuperPaths with SAG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SAG
        Visual Cycle in Retinal Rods

    2 Cell Signaling Technology (CST) Pathways for SAG
        Ca, cAMP and Lipid Signaling
    Neuroscience

    1 BioSystems Pathway for SAG
        Visual signal transduction- Rods

    1 Reactome Pathway for SAG
        Inactivation, recovery and regulation of the phototransduction cascade


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAG
    Interactions:

        GeneGlobe Interaction Network for SAG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SAG (P105233 ENSP000003864444) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRM2P081723, ENSP000003199844I2D: score=1 STRING: ENSP00000319984
    ADRA1BP353683, ENSP000003066624I2D: score=1 STRING: ENSP00000306662
    RHOP081003, ENSP000002962714I2D: score=2 STRING: ENSP00000296271
    ARRB1P494073I2D: score=1 
    ARRB2P321213I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway TAS7670478
    GO:0007601visual perception IEA--
    GO:0007603phototransduction, visible light TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    Find genes that share ontologies with SAG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAG (ARRS)

    1 HMDB Compound for SAG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for SAG gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorhodopsin 90.7 10 16547131 (2), 9624137 (1), 17848565 (1), 9188704 (1) (see all 6)
    metarhodopsin ii 83.6 33 9047319 (5), 10969086 (3), 8446607 (2), 8639666 (2) (see all 13)
    retinoid 43.8 13 9317106 (1), 12937633 (1), 8393049 (1), 11498256 (1) (see all 11)
    threonine 42.7 9 17981995 (1), 17995450 (1), 14636063 (1), 12424254 (1) (see all 7)
    hydroxylamine 31.2 5 16547131 (2), 9775211 (1)
    serine 27.1 9 18096696 (1), 17981995 (1), 17995450 (1), 12424254 (1) (see all 7)
    phytate 23.5 3 18161994 (1), 1765153 (1), 16439357 (1)
    cgmp 18.6 5 10052946 (1), 2158671 (1), 18184973 (1), 17928024 (1)
    morphine 15.9 8 16682505 (1), 10443588 (1), 9707575 (1), 11584310 (1) (see all 6)
    vitamin a 14.7 7 11078833 (1), 7662865 (1), 9673006 (1), 8305429 (1) (see all 6)



    Find genes that share compounds with SAG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SAG gene: 
    NM_000541.4  

    Unigene Cluster for SAG:

    S-antigen; retina and pineal gland (arrestin)
    Hs.32721  [show with all ESTs]
    Unigene Representative Sequence: NM_000541
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447536(uc002vug.2) ENST00000476500 ENST00000409110(uc002vuh.2 uc010zmq.1)
    ENST00000462487 ENST00000471884 ENST00000479450 ENST00000415974 ENST00000412969
    ENST00000453143 ENST00000474206 ENST00000461532 ENST00000469222 ENST00000483231
    ENST00000473771 ENST00000474220 ENST00000492629 ENST00000449594
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SAG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SAG
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SAG
    Predesigned siRNA for gene silencing in human, mouse, rat SAG
    Clone
    Products:
         
    OriGene clones in human, mouse for SAG (see all 6)
    OriGene ORF clones in mouse, rat for SAG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAG (NM_000541)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAG
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SAG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAG
      QuantiTect SYBR Green Assays in human, mouse, rat SAG
      QuantiFast Probe-based Assays in human, mouse, rat SAG

    Additional mRNA sequence: 

    AK302211.1 BC144203.1 DQ980618.1 DQ980619.1 DQ980620.1 X12453.1 

    15 DOTS entries:

    DT.453624  DT.97777873  DT.40260079  DT.95155893  DT.100719466  DT.97785391  DT.97800611  DT.100735827 
    DT.101957023  DT.97801983  DT.97841966  DT.100675003  DT.101969215  DT.40111426  DT.99949387 

    Selected AceView cDNA sequences (see all 121):

    BX642426 BQ637870 BU733194 BQ637563 BQ638873 AL711340 AA057232 AA918179 
    H91939 BQ638994 BQ636721 BQ635890 BQ639030 BU733802 BQ640103 BM695644 
    BQ636406 CA392727 BQ639204 BQ638804 BU734369 BQ636317 BQ638179 BQ635987 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SAG (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
    SP1:                          -                       -                             -                                                                     
    SP2:                                                  -                             -                                                                     
    SP3:                                                  -                                                                                                   
    SP4:                                                                                -                                                                     
    SP5:                          -                       -     -                                                                                             


    ECgene alternative splicing isoforms for SAG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SAG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCCTCAGC
    SAG Expression
    About this image


    SAG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina
             Photoreceptor-like cells
     
     NULL (Sensory Organs)    fully expand to see all 2 entries
             Photoreceptor-like cells
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
    SAG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32721

    UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523
    Tissue specificity: Retina and pineal gland

        Custom PCR Arrays for SAG
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SAG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAG
    QuantiTect SYBR Green Assays in human, mouse, rat SAG
    QuantiFast Probe-based Assays in human, mouse, rat SAG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SAG gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sag1 , 5 retinal S-antigen5
    S-antigen, retina and pineal gland (arrestin)1
    86.18(n)1
    88.94(a)1
      1 (44.44 cM)5
    202151  NM_009118.21  NP_033144.11 
     878036805 
    chicken
    (Gallus gallus)
    Aves SAG1 S-antigen; retina and pineal gland (arrestin) 70.93(n)
    72.38(a)
      768877  XM_004936936.1  XP_004936993.1 
    lizard
    (Anolis carolinensis)
    Reptilia SAG6
    S-antigen; retina and pineal gland (arrestin)
    63(a)
    1 ↔ 1
    3(35962025-35976043)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981092 arrestin 73.8(n)    U41623.1 
    zebrafish
    (Danio rerio)
    Actinopterygii saga1 S-antigen; retina and pineal gland (arrestin) a 63.4(n)
    58.89(a)
      792319  NM_200559.1  NP_956853.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arr13 deactivation of rhodopsin mediated
    signaling metarhodopsin more
    42(a)
    (best of 2)
      36D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea arr-16
    Protein ARR-1 (arr-1) mRNA, complete cds
    39(a)
    1 → many
    X(950782-954233) WBGene00000195


    ENSEMBL Gene Tree for SAG (if available)
    TreeFam Gene Tree for SAG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SAG gene
    ARR32  ARRB22  ARRB12  
    6 SIMAP similar genes for SAG using alignment to 5 protein entries:     ARRS_HUMAN (see all proteins):
    DKFZp686J1593    DKFZp686I1383    ARRB1    ARRB2    ARR3    DKFZp686L0365

    Find genes that share paralogs with SAG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SAG (see all 1000)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3759806641,2
    C--226023144(+) GCTAA-/TCTTTTT 1 -- int10--------
    rs1923588441,2
    C--226039973(+) TTCCTC/TCCTCC 1 -- int10--------
    rs1404433041,2
    C--233587355(+) GCCTGC/GGTGAC 1 -- us2k10--------
    rs1854325631,2
    --233587378(+) TGTCTC/TTAAAA 1 -- us2k10--------
    rs1443158951,2
    --233587402(+) GCTCAA/GTACTC 1 -- us2k10--------
    rs1473448561,2
    --233587568(+) TTTCTA/GCATAT 1 -- us2k10--------
    rs1394715861,2
    C--233587621(+) GTGGTC/TGCAGA 1 -- us2k10--------
    rs75885091,2
    C,F,A,H--233587792(+) aaatgT/Cggcca 1 -- us2k121Minor allele frequency- C:0.22NS EA NA WA CSA 2362
    rs1892956351,2
    --233587803(+) GGCACA/GGTAGC 1 -- us2k10--------
    rs1173883341,2
    C,F--233587819(+) CCTATA/GATCCC 1 -- us2k11Minor allele frequency- G:0.03EA 120

    HapMap Linkage Disequilibrium report for SAG (234216309 - 234255701 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SAG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678091CNV Deletion23128226
    dgv495n27CNV Loss19166990

    Human Gene Mutation Database (HGMD): SAG
    Locus Specific Mutation Databases (LSDB): SAG

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SAG
    DNA2.0 Custom Variant and Variant Library Synthesis for SAG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 181031   
    OMIM disorders: 258100  613758  
    UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523
  • Night blindness, congenital stationary, Oguchi type 1 (CSNBO1) [MIM:258100]: A non-progressive retinal
    disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital
    stationary night blindness Oguchi type is an autosomal recessive form associated with fundus discoloration and
    abnormally slow dark adaptation. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Retinitis pigmentosa 47 (RP47) [MIM:613758]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for SAG (see all 27):    
    About MalaCards
    eales disease    oguchi disease 1    sag-related retinitis pigmentosa    retinal vasculitis
    medullomyoblastoma    melanoma-associated retinopathy    retinitis pigmentosa 47    cerebellar medulloblastoma
    chorioretinitis    endophthalmitis    pineoblastoma    acute zonal occult outer retinopathy
    pineocytoma    posterior uveitis    uveitis    hereditary night blindness
    helminthiasis    acute disseminated encephalomyelitis    central neurocytoma    retinopathy of prematurity

    6 diseases from the University of Copenhagen DISEASES database for SAG:
    Uveitis     Hereditary night blindness     Chorioretinitis     Hepatitis B
    Retinitis     Retinal degeneration

    Find genes that share disorders with SAG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SAG gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oguchis disease 92 19 15295660 (2), 10549660 (2), 9020843 (2), 9501883 (2) (see all 12)
    uveitis 80.6 93 10471975 (4), 18958488 (4), 1635290 (3), 8162968 (2) (see all 53)
    retinal degeneration 70.4 10 12637747 (1), 17069872 (1), 10339543 (1), 15541899 (1) (see all 10)
    night blindness 67.7 8 10549660 (2), 11078833 (1), 9497461 (1), 9501883 (1) (see all 6)
    pineocytoma 65.7 1 7821912 (1)
    uveitis posterior 63.2 4 11263956 (1), 15010290 (1), 1289136 (1), 8223035 (1)
    pineal tumors 59.1 4 8360704 (2), 20418777 (1)
    pineoblastoma 55.6 2 7821912 (1), 8360704 (1)
    retinal vasculitis 54.8 3 1598962 (2), 18421236 (1)
    retinopathy 49.1 7 12608038 (2), 10339543 (1), 18814277 (1), 16030131 (1) (see all 6)

    Genetic Association Database (GAD): SAG
    Human Genome Epidemiology (HuGE) Navigator: SAG (4 documents)

    Export disorders for SAG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SAG gene, integrated from 10 sources (see all 446):
    (articles sorted by number of sources associating them with SAG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of the human arrestin gene in patients with retinitis pigmentosa and stationary night blindness. (PubMed id 9501883)1, 2, 9 Sippel K.C.... Dryja T.P. (Invest. Ophthalmol. Vis. Sci. 1998)
    2. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. (PubMed id 9020843)1, 2, 9 Yamamoto S.... Dryja T.P. (Nat. Genet. 1997)
    3. Robust self-association is a common feature of mammalian visual arrestin-1. (PubMed id 21288033)1, 2 Kim M....Gurevich V.V. (Biochemistry 2011)
    4. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    5. Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)1, 2 Roni V.... Wissinger B. (BMC Genomics 2007)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese. (PubMed id 7670478)1, 2 Fuchs S.... Gal A. (Nat. Genet. 1995)
    8. Structural organization of the human S-antigen gene. cDNA, amino acid, intron, exon, promoter, in vitro transcription, retina, and pineal gland. (PubMed id 2249983)1, 3 Yamaki K....Shinohara T. (J. Biol. Chem. 1990)
    9. The sequence of human retinal S-antigen reveals similarities with alpha-transducin. (PubMed id 3164688)1, 2 Yamaki K.... Shinohara T. (FEBS Lett. 1988)
    10. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PubMed id 7695743)1, 9 Calabrese G....De Blasi A. (Genomics 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6295 HGNC: 10521 AceView: SAG Ensembl:ENSG00000130561 euGenes: HUgn6295
    ECgene: SAG H-InvDB: SAG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SAG Pharmacogenomics, SNPs, Pathways
    Mutations of the SAG genehttp://www.retina-international.org/files/sci-news/sagmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SAG[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SAG gene:
    Search GeneIP for patents involving SAG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SAG   OriGene RNAi products in human, mouse, rat for SAG  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SAG  
     OriGene MassSpec for SAG   OriGene clones in human, mouse for SAG  
     OriGene qSTAR qPCR primer pairs in human, mouse for SAG   OriGene Purified Protein for SAG  
     OriGene ORF clones in mouse, rat for SAG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SAG   OriGene Custom Protein Services for SAG  

     
     
     Block miRNA regulation of human, mouse, rat SAG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SAG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAG Predesigned siRNA for gene silencing in human, mouse, rat SAG
     QuantiFast Probe-based Assays in human, mouse, rat SAG QuantiTect SYBR Green Assays in human, mouse, rat SAG
     Custom PCR Arrays for SAG Search Chromatin IP Primers for SAG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAG  GeneGlobe Interaction Network for SAG
     Regulatory tfbs in SAG promoter
     GenScript Custom Purified and Recombinant Proteins Services for SAG GenScript cDNA clones with any tag delivered in your preferred vector for SAG
     GenScript Custom Assay Services for SAG GenScript Custom overexpressing Cell Line Services for SAG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SAG 

     Search Tocris compounds for SAG (ARRS)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SAG antibodies
     SAG proteins
     SAG lysates
     Antibodies for SAG
     See all of Abcam's Antibodies, Kits and Proteins for SAG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SAG
     Antibodies for SAG
     ELISAs for SAG
     CLIAs for SAG



     Browse ESI BIO Cell Lines and PureStem Progenitors for SAG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAG
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SAG
     Browse SwitchGear Promoter luciferase reporter plasmids for SAG
     ThermoFisher Antibody for SAG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAG
     Browse compounds at ApexBio
     Search Addgene for plasmids for SAG
      Search eBioscience for proteins for SAG
      Search eBioscience for elisas for SAG
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SAG
     antibodies-online antibodies for SAG (44 products)
     antibodies-online kits for SAG (29 products)
      Search antibodies-online for peptides for SAG
     antibodies-online proteins for SAG (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SAG gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4