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SAG Gene

protein-coding GIFtS: 60

GC02P233881

S-antigen; retina and pineal gland (arrestin)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARRESTIN ^¹
DKFZp686D1084 ^²
DKFZp686I1383 ^²
RP47 ^², ⁵
S-AG ^², ³
S-arrestin ^²

Descriptions
48 kDa protein ^³
Retinal S-antigen ^³
Rod photoreceptor arrestin ^², ³
S-antigen; retina and pineal gland (arrestin) ^²
arrestin 1 ^²
retinal S-antigen (48 KDa protein) ^²

External Ids
HGNC: 10521¹
Entrez Gene: 6295²
UniProtKB: P10523³
Ensembl: ENSG00000130561⁷

Search outside databases for aliases for SAG gene

Previous GC identifers: GC02P232224 GC02P232898 GC02P234232 GC02P234503 GC02P233998

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SAG:

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated

desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses

to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as

S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the

photoactivated transduction cascade. It is expressed in the retina and the pineal gland and

inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly

antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this

gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523

Function: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds

to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated

activation of phosphodiesterase

Gene Wiki entry for SAG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAG gene

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

SAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P233881: (about GC identifiers)

Start:	233,881,206 bp from pter
End:	233,920,440 bp from pter
Size:	39,235 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005120.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523 (See protein sequence)

Recommended Name: S-arrestin

Size: 405 amino acids; 45120 Da

Miscellaneous: Arrestin binds calcium

Secondary accessions: Q53SV3 Q99858

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000532.2

ENSEMBL proteins:

ENSP00000252857 ENSP00000386444 ENSP00000379782

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Retinal S antigen)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for SAG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Retinal S antigen), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for SAG

Assays for SAG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P10523

ProtoNet protein and cluster: P10523

1 Blocks protein family: IPB000698 Arrestin

UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523

Similarity: Belongs to the arrestin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000541

Applied Biosystems Silencer® siRNAs for SAG

Sigma-Aldrich siRNA and siRNA Panels for SAG

Sigma-Aldrich shRNA Panels and shRNA for SAG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000541
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000541
untagged cDNA clone in CMV expression vector: NM_000541

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000541

UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523

Function: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds

to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated

activation of phosphodiesterase

Genatlas biochemistry entry for SAG:

S-antigen (48kDa),Ca2+ binding,P-rhodopsin inhibitory binding protein (arrestin),retina and pineal

gland,cofactor of rhodopsin kinase

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004864	phosphoprotein phosphatase inhibitor activity	TAS	2550422
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	TAS	2550422

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAG (Your Favorite Gene powered by Ingenuity)

Phototransduction Pathway

GeneDecks SAG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SAG

5/31 Interacting proteins for SAG (ENSP00000252857³) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHO	ENSP00000296271³	STRING (score=.999)
GRK1	ENSP00000334876³	STRING (score=.991)
CHRM2	ENSP00000319984³	STRING (score=.978)
MAPK10	ENSP00000352157³	STRING (score=.957)
ADRB2	ENSP00000305372³	STRING (score=.955)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor linked signal transduction	TAS	7670478
GO:0007600	sensory perception	IEA	--
GO:0007601	visual perception	IEA	--
GO:0009586	rhodopsin mediated phototransduction	TAS	7670478
GO:0016056	rhodopsin mediated signaling pathway	TAS	2550422

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAG
10/22 Novoseek chemical compound relationships for SAG gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphorhodopsin	90.93	10	16547131 (2), 9624137 (1), 17848565 (1), 9188704 (1) (see all 6)
metarhodopsin ii	82.76	32	9047319 (5), 10969086 (3), 8446607 (2), 8639666 (2) (see all 12)
threonine	38.81	9	17981995 (1), 17995450 (1), 14636063 (1), 12424254 (1) (see all 7)
hydroxylamine	32.78	5	16547131 (2), 9775211 (1)
phytate	25.23	3	18161994 (1), 1765153 (1), 16439357 (1)
cgmp	20.13	5	10052946 (1), 2158671 (1), 18184973 (1), 17928024 (1)
cyclic amp	14.31	1	10807316 (1)
okadaic acid	13.17	1	9839968 (1)
phosphoinositide	9.29	3	10022830 (3)
guanylate	3.97	2	18456304 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000541

Sigma-Aldrich siRNA and siRNA Panels for SAG

Sigma-Aldrich shRNA Panels and shRNA for SAG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000541

REFSEQ mRNAs for SAG gene:

NM_000541.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000541

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000541
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000541
                                 untagged cDNA clone in CMV expression vector: NM_000541

Additional cDNA sequence:

AK302211.1 BC144203.1 DQ980618.1 DQ980619.1 DQ980620.1 X12453.1

15 DOTS entries:

DT.453624 DT.97777873 DT.40260079 DT.95155893 DT.100719466 DT.97785391 DT.97800611 DT.100735827

DT.101957023 DT.97801983 DT.97841966 DT.99949387 DT.100675003 DT.101969215 DT.40111426

24/121 AceView cDNA sequences (see all 121 ):

BU734369 AA918179 BQ636406 BQ639204 BQ636469 BQ639460 BQ639030 CA392727

BU733802 BQ636721 BQ637563 BX642424 BQ640103 BU733194 H38275 BQ638994

BQ635890 AL713222 BQ640682 BM709760 BQ639557 BQ637870 BU734243 BQ638493

highest scoring ESTs for SAG:

AA013127 AA016043 AA017159 AA021568 AA047885 AA053951 AA057233 AA058468 AA904507 AA918179

Unigene Cluster for SAG:

S-antigen; retina and pineal gland (arrestin)

Hs.32721 [show with all ESTs]

Unigene Representative Sequence: NM_000541

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SAG (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	^	13
SP1:									-								-										-
SP2:																	-										-
SP3:																	-
SP4:																											-
SP5:									-								-		-

About this scheme

ECgene alternative splicing isoforms for SAG

3 Ensembl transcripts including schematic representations:

ENST00000252857 ENST00000409110 ENST00000396530

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAG

¹ / ² / ³

8 probe-sets matching SAG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35661_g_at²^{, 3}	U95-A	1	1.00	1.00	0.31	0.18	X12453	0.80	1.00	0.91	1
35660_at²^{, 3}	U95-A	1	1.00	1.00	0.27	0.18	X12453	0.80	1.00	0.91	1
60073_f_at²^{, 3}	U95-C	3330	0.88	0.00	0.65	1.22	AA525753	0.20	1.00	0.72	1
31759_at²^{, 3}	U95-A	1	0.75	1.00	0.65	0.45	W26220	0.40	1.00	0.76	1
63729_f_at²	U95-C	2990	0.75	0.02	0.66	1.16	--	--	--	--	--
51043_f_at²^{, 3}	U95-C	2103	0.44	0.01	0.72	1.17	AA743794	0.20	0.11	0.16	2
206671_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000541	0.60	1.00	0.82	1
206671_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACCCTCAGC

SOURCE GeneReport for Unigene cluster: Hs.32721
Expression variation in blood from EXPOLDB for SAG
UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523
Tissue specificity: Retina and pineal gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAG gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAG¹	--	S-antigen; retina and pineal gland (arrestin)	87.51(n) 89.58(a)	403906 XM_850486.1 XP_855579.1
chimpanzee (Pan troglodytes)	SAG¹	--	S-antigen; retina and pineal gland (arrestin)	99.28(n) 99.19(a)	460023 XM_001150569.1 XP_001150569.1
cow (Bos taurus)	SAG¹	--	S-antigen; retina and pineal gland (arrestin)	86.07(n) 87.7(a)	280922 NM_181000.2 NP_851343.1
rat (Rattus norvegicus)	Sag¹	--	S-antigen; retina and pineal gland (arrestin)	86.68(n) 90.2(a)	25539 NM_013023.2 NP_037155.2
mouse (Mus musculus)	Sag^{1, 5}	1 (53.60 cM)⁵	retinal S-antigen^{1, 5}	86.18(n)¹ 88.94(a)¹	20215¹ NM_009118.2¹ NP_033144.1¹ AK044214⁵ AK053278⁵ (see all 11)

About this table Species with no ortholog for SAG

ENSEMBL Gene Tree for SAG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for SAG gene

ARRB2² ARR3² ARRB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/310 NCBI SNPs in SAG are shown (see all 310 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1046974^1,2	A,C,F,H,O	233920286(+)	`ATGACG/ATTGAT`	1	I/V	mis¹ ese³		9		MN EU EA WA	1020
	rs7588509^1,2	A,C,F,H	233879686(+)	`aaatgT/Cggcca`	1	--	ng5¹		7		EU EA WA NA	558
	rs7565275^1,2	C,F,H	233894059(+)	`AGGACA/GTTGAC`	1	I/V	mis¹ ese³		8		EU EA WA	838
--	rs1046976^1,2	C,F,H	233920287(+)	`TGACGT/CTGATG`	1	A/V	mis¹ ese³		6		MN WA EU EA	720
	rs692^1,2	F	233920304(+)	`GATGTC/TGGCTC`	1	--	ut3¹		1		MN	184
--	rs13410916^1,2	A	233880551(+)	`gggagA/Gcagaa`	1	--	ng5¹		0	--	--	--	--
--	rs6719241^1,2	A	233879965(+)	`aaagaG/Ttgaaa`	1	--	ng5¹ trp³		0	--	--	--	--
	rs2304773^1,2	C,F,H	233900559(-)	`TCTTCG/AGCATC`	1	A/A	syn¹ ese³		9		EA EU WA	2006
	rs1000141^1,2	A,C,F,H,O	233907086(-)	`TTTTTG/ATGTTT`	1	--	int¹		26		EA NA EU WA CA CSAM	2091
	rs3792096^1,2	A,C,F,H	233903639(-)	`GTCATC/TGAATG`	1	--	int¹		8		EU EA WA	836

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HapMap Linkage Disequilibrium images for SAG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 181031

UniProtKB/Swiss-Prot: ARRS_HUMAN, P10523

S-antigen induces autoimmune uveitis

Defects in SAG are a cause of congenital stationary night blindness Oguchi type (CSNBO)

[MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a

non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal

recessive form associated with fundus discoloration and abnormally slow dark adaptation

10/39 Novoseek disease relationships for SAG gene (see all 39 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oguchis disease	92.57	19	15295660 (2), 10549660 (2), 9020843 (2), 9501883 (2) (see all 12)
uveitis	81.01	91	10471975 (4), 18958488 (4), 1635290 (3), 8162968 (2) (see all 52)
retinal degeneration	70.48	10	12637747 (1), 17069872 (1), 10339543 (1), 15541899 (1) (see all 10)
night blindness	68.91	8	10549660 (2), 11078833 (1), 9497461 (1), 9501883 (1) (see all 6)
uveitis posterior	64.72	4	11263956 (1), 15010290 (1), 1289136 (1), 8223035 (1)
pineocytoma	62.29	1	7821912 (1)
retinal vasculitis	56.28	3	1598962 (2), 18421236 (1)
pineal tumors	50.51	3	8360704 (2)
pineoblastoma	49.92	2	7821912 (1), 8360704 (1)
retinitis pigmentosa	48.76	6	1974891 (2), 10943838 (1), 18175313 (1), 9501883 (1) (see all 5)

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Human Gene Mutation Database: SAG

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/402 PubMed articles for SAG gene (see all 402 ):

Evaluation of the human arrestin gene in patients with retinitis pigmentosa and stationary night blindness. (PubMed id 9501883)^{1, 3, 4} Sippel K.C.... Dryja T.P. (1998)
Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. (PubMed id 9020843)^{1, 3, 4} Yamamoto S.... Dryja T.P. (1997)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Structural organization of the human S-antigen gene. cDNA, amino acid, intron, exon, promoter, in vitro transcription, retina, and pineal gland. (PubMed id 2249983)^{2, 3} Yamaki K....Shinohara T. (1990)
The sequence of human retinal S-antigen reveals similarities with alpha-transducin. (PubMed id 3164688)^{3, 4} Yamaki K.... Shinohara T. (1988)
Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PubMed id 7695743)^{1, 3} Calabrese G....De Blasi A. (1994)
In silico study of the human rhodopsin and meta rhodopsin II/S-arrestin complexes: impact of single point mutations related to retina degenerative diseases. (PubMed id 18175313)^{1, 3} Mokarzel-Falcon L....Montero-Cabrera L.A. (2008)
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. (PubMed id 15713799)^{1, 3} Howard O.M....Oppenheim J.J. (2005)
Structure and function of the visual arrestin oligomer. (PubMed id 17332750)^{1, 3} Hanson S.M....Gurevich V.V. (2007)
Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestins. (PubMed id 10952973)^{1, 3} Lee K.B....Hosey M.M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6295	HGNC: 10521	AceView: SAG	Ensembl:ENSG00000130561	euGenes: HUgn6295
ECgene: SAG	H-InvDB: SAG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Mutations of the SAG gene	http://www.retina-international.com/sci-news/sagmut.htm
GeneReviews	http://www.genetests.org/query?gene=SAG

Licensable Technologies for SAG
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SAG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAG		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for SAG

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SAG Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for SAG

Summaries
for SAG

Genomic Location
for SAG

Proteins
for SAG

Protein Domains/
Families
for SAG

Gene Function
for SAG

Pathways & Interactions
for SAG

Drugs & Compounds
for SAG

Transcripts
for SAG

Expression
for SAG

Orthologs
for SAG

Paralogs
for SAG

SNPs/Variants
for SAG

Disorders & Mutations
for SAG

Medical News
for SAG

Publications
for SAG

Search for SAG

Genome Databases showing SAG

Other Databases showing SAG

Specialized Databases showing SAG

Licensable Technologies
for SAG

Services
for SAG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAG Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor SAG

Summariesfor SAG

Genomic Locationfor SAG

Proteinsfor SAG

Protein Domains/Familiesfor SAG

Gene Functionfor SAG

Pathways & Interactionsfor SAG

Drugs & Compoundsfor SAG

Transcriptsfor SAG

Expression for SAG

Orthologsfor SAG

Paralogsfor SAG

SNPs/Variantsfor SAG

Disorders & Mutationsfor SAG

Medical Newsfor SAG

Publicationsfor SAG

Search for SAG

Genome Databases showing SAG

Other Databases showing SAG

Specialized Databases showing SAG

Licensable Technologiesfor SAG

Servicesfor SAG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAG

Summaries
for SAG

Genomic Location
for SAG

Proteins
for SAG

Protein Domains/
Families
for SAG

Gene Function
for SAG

Pathways & Interactions
for SAG

Drugs & Compounds
for SAG

Transcripts
for SAG

Expression
for SAG

Orthologs
for SAG

Paralogs
for SAG

SNPs/Variants
for SAG

Disorders & Mutations
for SAG

Medical News
for SAG

Publications
for SAG

Licensable Technologies
for SAG

Services
for SAG