Aliases for SAG Gene
External Ids for SAG Gene
Previous GeneCards Identifiers for SAG Gene
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]
GeneCards Summary for SAG Gene
SAG (S-Antigen; Retina And Pineal Gland (Arrestin)) is a Protein Coding gene. Diseases associated with SAG include oguchi disease-1 and retinitis pigmentosa 47. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include phosphoprotein binding and opsin binding. An important paralog of this gene is ARRB2.
UniProtKB/Swiss-Prot for SAG Gene
Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.