 |
 | Services
| |
 |
Aliases & Descriptions for SAFB2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0138 1, 2, 3, 5 | | SAF-B2 3 |
| | | Descriptions |
|---|
| scaffold attachment factor B2 2 |
|
| | Search outside databases for aliases for SAFB2 genePrevious GC identifer: GC19M005527 |
Summaries for SAFB2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SAFB2_HUMAN, Q14151Function: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferationGene Wiki entry for SAFB2 |
Genomic Location for SAFB2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAFB2 gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3SAFB2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M005538:
(about GC identifiers)
Start:
|
5,538,010 bp from pter |
End:
|
5,573,938 bp from pter |
Size:
|
35,929 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for SAFB2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAFB2_HUMAN, Q14151 (See
protein sequence)Recommended Name: Scaffold attachment factor B2 Size: 953 amino acids; 107473 Da
Subunit: Interacts with SAFB/SAFB1 and SCAM1
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: Q8TB13Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055464.1
ENSEMBL proteins: ENSP00000378122 ENSP00000252542
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SAFB2: Assays for SAFB2: | Protein
Domains/ Families for SAFB2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14151
ProtoNet protein and cluster: Q14151 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB003034 DNA-binding SAP
UniProtKB/Swiss-Prot: SAFB2_HUMAN, Q14151Similarity: Contains 1 RRM (RNA recognition motif) domainSimilarity: Contains 1 SAP domain | Gene Function for SAFB2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014649
Applied Biosystems Silencer® siRNAs for SAFB2
Sigma-Aldrich siRNA for SAFB2  Sigma-Aldrich shRNA for SAFB2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014649                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014649                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014649 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014649
UniProtKB/Swiss-Prot: SAFB2_HUMAN, Q14151Function: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for SAFB2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for SAFB2 (ENSP000002525423 Q141512) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for SAFB2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAFB2
|
Transcripts for SAFB2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014649
Sigma-Aldrich siRNA for SAFB2  Sigma-Aldrich shRNA for SAFB2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014649 REFSEQ mRNAs for SAFB2 gene: NM_014649.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014649               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014649                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014649                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014649  Additional cDNA sequence: AK123246.1 AK296552.1 AK300501.1 BC001216.1 BC014784.1 BC025279.1 D50928.1 24/26 DOTS entries (see all 26
): DT.95284311 DT.75176560 DT.99958547 DT.99977968 DT.40110022 DT.100814583 DT.121455574 DT.97860337 DT.100737017 DT.40280613 DT.75103418 DT.91742864 DT.40306882 DT.75119206 DT.92030453 DT.121455580 DT.450237 DT.91863535 DT.95363107 DT.100040325 DT.100811853 DT.65287715 DT.97819785 DT.97820339 24/194 AceView cDNA sequences (see all 194
):BC014784 BM764466 AI168419 BU181609 CK430953 BQ672926 BE395325 BM708690 BM174910 BM683580 BQ920969 BE252761 AK123246 BC001216 BU161744 BM929597 BU195637 BE018969 BQ058036 BM718536 BM765758 BX283817 BQ883292 BM746190
highest scoring ESTs for SAFB2:D50928 AI587127 BE830657 BG436879 BM559198 BM753564 BM765758 AA286987 AW383803 BF328019 Unigene Cluster for SAFB2: Scaffold attachment factor B2 Hs.655392 [show with all ESTs]Unigene Representative Sequence: NM_014649
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SAFB2 (see all 8
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 20b | ^ | 21 | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   | |
| SP5: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SAFB2
2 Ensembl transcripts including schematic representations: ENST00000394625
ENST00000252542
|
Expression for SAFB2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAFB2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAFB2
1 / 2 / 3 5 probe-sets matching SAFB2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGTAGCTCA
SOURCE GeneReport for Unigene cluster: Hs.655392
Expression variation in blood from EXPOLDB for SAFB2 UniProtKB/Swiss-Prot: SAFB2_HUMAN, Q14151Tissue specificity: Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines |
Orthologs for SAFB2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAFB2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for SAFB2
ENSEMBL Gene Tree for SAFB2 | Paralogs for SAFB2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SAFB2 gene
- SLTM2 SAFB2
|
SNPs/Variants for SAFB2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAFB2 (up to first 250kb)
|
Disorders & Mutations for SAFB2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608066
|
Medical News for SAFB2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAFB2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for SAFB2 gene (see all 18
):- SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PubMed id 12660241)1, 2, 3, 4 Townson S.M.... Oesterreich S. (2003)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)3, 4 Nagase T....Nomura N. (1995)
- No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p. (PubMed id 19077293)1, 3 Bergman A....Nordling M. (2008)
- Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis? (PubMed id 14587024)1, 3 Oesterreich S. (2003)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for SAFB2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAFB2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAFB2
(According to HUGE)
About This Section
| |
Specialized Databases showing SAFB2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAFB2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SAFB2:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for SAFB2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|