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Aliases for SAFB2 Gene

Aliases for SAFB2 Gene

  • Scaffold Attachment Factor B2 2 3
  • KIAA0138 4 6
  • SAF-B2 3 4

External Ids for SAFB2 Gene

Summaries for SAFB2 Gene

GeneCards Summary for SAFB2 Gene

SAFB2 (Scaffold Attachment Factor B2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SLTM.

UniProtKB/Swiss-Prot for SAFB2 Gene

  • Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation

Gene Wiki entry for SAFB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAFB2 Gene

Genomics for SAFB2 Gene

Genomic Location for SAFB2 Gene

Start:
5,586,996 bp from pter
End:
5,624,046 bp from pter
Size:
37,051 bases
Orientation:
Minus strand

Genomic View for SAFB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAFB2 Gene

Regulatory Elements for SAFB2 Gene

Proteins for SAFB2 Gene

  • Protein details for SAFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14151-SAFB2_HUMAN
    Recommended name:
    Scaffold attachment factor B2
    Protein Accession:
    Q14151
    Secondary Accessions:
    • B4DKG3
    • Q8TB13

    Protein attributes for SAFB2 Gene

    Size:
    953 amino acids
    Molecular mass:
    107473 Da
    Quaternary structure:
    • Interacts with SAFB/SAFB1 and SCAM1. Interacts with isoform 2 SRPK1 and inhibits its activity.
    SequenceCaution:
    • Sequence=BAA09487.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SAFB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAFB2 Gene

Proteomics data for SAFB2 Gene at MOPED

Post-translational modifications for SAFB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys293, Lys424, Lys429, and Lys616

Other Protein References for SAFB2 Gene

No data available for DME Specific Peptides for SAFB2 Gene

Domains for SAFB2 Gene

Gene Families for SAFB2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

SAFB2_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q14151
  • Contains 1 SAP domain.:
    • Q14151
genes like me logo Genes that share domains with SAFB2: view

Function for SAFB2 Gene

Molecular function for SAFB2 Gene

UniProtKB/Swiss-Prot Function: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation

Gene Ontology (GO) - Molecular Function for SAFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 12660241
GO:0042802 identical protein binding IPI 19674106
genes like me logo Genes that share ontologies with SAFB2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SAFB2 Gene

Localization for SAFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAFB2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAFB2 Gene COMPARTMENTS Subcellular localization image for SAFB2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SAFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with SAFB2: view

Pathways for SAFB2 Gene

SuperPathways for SAFB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SAFB2: view

No data available for Pathways by source for SAFB2 Gene

Transcripts for SAFB2 Gene

Unigene Clusters for SAFB2 Gene

Scaffold attachment factor B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAFB2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a ·
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

ExUns: 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SAFB2 Gene

GeneLoc Exon Structure for
SAFB2
ECgene alternative splicing isoforms for
SAFB2

Expression for SAFB2 Gene

mRNA expression in normal human tissues for SAFB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAFB2 Gene

SOURCE GeneReport for Unigene cluster for SAFB2 Gene Hs.655392

mRNA Expression by UniProt/SwissProt for SAFB2 Gene

Q14151-SAFB2_HUMAN
Tissue specificity: Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines
genes like me logo Genes that share expressions with SAFB2: view

Orthologs for SAFB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAFB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAFB2 36
  • 99.58 (n)
  • 99.69 (a)
SAFB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAFB2 36
  • 85.57 (n)
  • 84.69 (a)
SAFB2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAFB2 36
  • 88.31 (n)
  • 89.08 (a)
SAFB2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Safb2 36
  • 77.17 (n)
  • 74.23 (a)
Safb2 16
Safb2 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Safb2 36
  • 75.69 (n)
  • 72.28 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 59 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.5490 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14461 36
zebrafish
(Danio rerio)
Actinopterygii safb 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Saf-B 37
  • 23 (a)
OneToMany
Species with no ortholog for SAFB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAFB2 Gene

ENSEMBL:
Gene Tree for SAFB2 (if available)
TreeFam:
Gene Tree for SAFB2 (if available)

Paralogs for SAFB2 Gene

Paralogs for SAFB2 Gene

Selected SIMAP similar genes for SAFB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SAFB2: view

Variants for SAFB2 Gene

Sequence variations from dbSNP and Humsavar for SAFB2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs708691 -- 5,615,659(+) atgac(A/C)ccact intron-variant
rs733449 -- 5,586,809(+) TCCCA(C/T)GATGG downstream-variant-500B
rs739941 -- 5,599,140(+) CAGCA(C/T)GCACA intron-variant
rs739942 -- 5,599,504(-) TACAA(C/G)CTGGA intron-variant
rs739943 -- 5,599,826(-) TTGTC(C/T)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAFB2 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv2395 CNV Insertion 18451855

Relevant External Links for SAFB2 Gene

HapMap Linkage Disequilibrium report
SAFB2
Human Gene Mutation Database (HGMD)
SAFB2

Disorders for SAFB2 Gene

Relevant External Links for SAFB2

Human Genome Epidemiology (HuGE) Navigator
SAFB2
genes like me logo Genes that share disorders with SAFB2: view

No data available for UniProtKB/Swiss-Prot for SAFB2 Gene

Publications for SAFB2 Gene

  1. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PMID: 12660241) Townson S.M. … Oesterreich S. (J. Biol. Chem. 2003) 2 3 4 23
  2. Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis? (PMID: 14587024) Oesterreich S. (J. Cell. Biochem. 2003) 3 23
  3. No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p. (PMID: 19077293) Bergman A. … Nordling M. (BMC Med. Genet. 2008) 3 23
  4. Low SAFB levels are associated with worse outcome in breast cancer patients. (PMID: 19137425) Hammerich-Hille S. … Oesterreich S. (Breast Cancer Res. Treat. 2010) 3 23
  5. SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells. (PMID: 19901029) Hammerich-Hille S. … Oesterreich S. (J. Biol. Chem. 2010) 3 23

Products for SAFB2 Gene

Sources for SAFB2 Gene

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