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SAFB Gene

protein-coding GIFtS: 62

GC19P005574

scaffold attachment factor B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp779C1727 ^²
HAP ^², ³
HET ^¹, ², ³, ⁵
SAB-B1 ^³
SAF-B ^³
SAFB1 ^¹, ², ³

Descriptions
HSP27 ERE-TATA-binding protein ^², ³
HSP27 estrogen response element-TATA box-binding protein ^³
Hsp27 ERE-TATA binding protein ^²
glutathione S-transferase fusion protein ^²
heat-shock protein (HSP27) estrogen response element and TATA box-binding protein ^²
scaffold attachment factor B ^²
scaffold attachment factor B1 ^²

External Ids
HGNC: 10520¹
Entrez Gene: 6294²
UniProtKB: Q15424³
Ensembl: ENSG00000160633⁷

Search outside databases for aliases for SAFB gene

Previous GC identifers: GC19P005715 GC19P005563

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SAFB:

This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment

region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of

chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein

is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a

specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded

protein is thought to serve as a molecular base to assemble a 'transcriptosome complex'

in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock

protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a

candidate gene for breast tumorigenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424

Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly

point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA

polymerase II) coupling transcription and RNA processing (By similarity). Can function as an

estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its

transcription. Can inhibit cell proliferation

Gene Wiki entry for SAFB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAFB gene

Entrez Gene cytogenetic band: 19p13.3-p13.2 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3-p13.2

SAFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P005574: (about GC identifiers)

Start:	5,574,164 bp from pter
End:	5,619,489 bp from pter
Size:	45,326 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424 (See protein sequence)

Recommended Name: Scaffold attachment factor B1

Size: 915 amino acids; 102642 Da

Subunit: Monomer. Can form homodimers. Interacts with KHDRBS3, POLR2A, SAFB2 or SFRS1, SFRS9 and

TRA2B/SFRS10 (By similarity)

Subcellular location: Nucleus

Secondary accessions: O60406 Q59HH8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002958.2

ENSEMBL proteins:

ENSP00000292123

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SAFB)
	Human Recombinant Proteins from Abnova (SAFB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	1324173

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Antibodies for SAFB:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SAFB
	Sigma-Aldrich Antibodies for SAFB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SAFB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SAFB)
	Novus Biologicals Antibodies for SAFB

Assays for SAFB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15424

ProtoNet protein and cluster: Q15424

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB003034 DNA-binding SAP

UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424

Similarity: Contains 1 RRM (RNA recognition motif) domain

Similarity: Contains 1 SAP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAFB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAFB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002967

Applied Biosystems Silencer® siRNAs for SAFB

Sigma-Aldrich siRNA for SAFB

Sigma-Aldrich shRNA for SAFB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002967
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002967
untagged cDNA clone in CMV expression vector: NM_002967

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002967

UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424

Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly

point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA

polymerase II) coupling transcription and RNA processing (By similarity). Can function as an

estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its

transcription. Can inhibit cell proliferation

Genatlas biochemistry entry for SAFB:

scaffold attachment factor B,97kDa,ubiquitously expressed protein (hsp27 promoter binding-protein)

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Safb):

behavior/neurological	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
lethality-prenatal/perinatal	liver/biliary system	reproductive system	respiratory system	skeleton

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003690	double-stranded DNA binding	TAS	1324173
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	14667819

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAFB (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling

GeneDecks SAFB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SAFB

5/14 Interacting proteins for SAFB (ENSP00000292123³ Q15424^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000096467	O95870¹^,²	EBI-348298, EBI-348517 MINT-62607 MINT-62705 MINT-62781
ENSG00000206403	O95870¹^,²	EBI-348298, EBI-348517 MINT-62607 MINT-62705 MINT-62781
BAT5	O95870¹^,²	EBI-348298, EBI-348517 MINT-62607 MINT-62705 MINT-62781 EBI-348298, EBI-348517 MINT-62607 MINT-62705 MINT-62781
BAT5	O95870¹^,²	EBI-348298, EBI-348517 MINT-62607 MINT-62705 MINT-62781 EBI-348298, EBI-348517 MINT-62607 MINT-62705 MINT-62781
CHD3	Q12873²	MINT-64244

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006325	establishment or maintenance of chromatin architecture	TAS	1324173
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAFB
10/20 Novoseek chemical compound relationships for SAFB gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	59.13	22	8943314 (1), 1334490 (1), 17942635 (1), 9886379 (1) (see all 18)
phosphotyrosine	51.61	3	8619495 (1), 10749687 (1), 8188688 (1)
gdp	47.30	3	16138900 (1), 7513052 (1), 11073942 (1)
phosphatidylinositol	46.92	6	8603102 (1), 8413261 (1), 8058768 (1), 8388538 (1) (see all 5)
gtp	30.86	4	16138900 (1), 17995937 (1), 8940119 (1)
zinc	19.53	11	7782343 (1), 18760786 (1), 8521965 (1), 8300628 (1) (see all 9)
atp	17.08	5	8608138 (1), 10510297 (1), 16621795 (1), 12511576 (1) (see all 5)
oligonucleotide	5.10	1	7799919 (1)
cytidine	4.00	2	7782343 (1)
allergens	2.97	1	9751846 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAFB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAFB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002967

Sigma-Aldrich siRNA for SAFB

Sigma-Aldrich shRNA for SAFB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002967

REFSEQ mRNAs for SAFB gene:

NM_002967.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002967

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002967
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002967
                                 untagged cDNA clone in CMV expression vector: NM_002967

Additional cDNA sequence:

AB208780.1 AK095736.1 AK290444.1 AK293152.1 AK294671.1 AK294718.1 AK295298.1 AK298707.1

AK299525.1 AK304474.1 AK307970.1 BC020309.1 BC032055.1 BC126219.1 BC143937.1 BC143938.1

BC143939.1 CR749251.1 L43631.1 U72355.1

22 DOTS entries:

DT.97820339 DT.92450357 DT.450237 DT.100705744 DT.95200171 DT.100811853 DT.100000471 DT.92450343

DT.100059666 DT.95284311 DT.40234561 DT.95363107 DT.102836891 DT.121455441 DT.121455473 DT.121455485

DT.86838544 DT.95154079 DT.95345451 DT.95363086 DT.91879950 DT.99953773

24/574 AceView cDNA sequences (see all 574 ):

BM021400 CA773593 CA394781 Z45303 AI992051 AW663387 BQ066836 BQ066725

BU508740 AA724017 BI966064 AA300602 BC032055 AI633984 BQ436711 AW138261

BU733521 BC020309 AI989953 AI523968 NM_002967 AW664045 AA280042 BQ058423

highest scoring ESTs for SAFB:

U72355 AA146656 AA227763 AA227801 AA227811 AA227930 AA227940 AA227965 AA280055 AA400878

Unigene Cluster for SAFB:

Scaffold attachment factor B

Hs.23978 [show with all ESTs]

Unigene Representative Sequence: CR749251

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SAFB (see all 11 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	·
SP1:																	-		-		-
SP2:
SP3:
SP4:
SP5:									-		-		-		-		-		-		-

ExUns:	15c	^	16	^	17	^	18	^	19	^	20a	·	20b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SAFB

1 Ensembl transcript including schematic representation:

ENST00000292123

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAFB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAFB

¹ / ² / ³

5 probe-sets matching SAFB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41316_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U72355	1.00	1.00	1.00	1
201747_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI769566	0.40	1.00	0.76	1
201748_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002967	0.60	1.00	0.82	1
201747_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201748_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGGGCGGGT

SOURCE GeneReport for Unigene cluster: Hs.23978
Expression variation in blood from EXPOLDB for SAFB
UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424
Tissue specificity: Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver.
Expressed in a wide number of breast cancer cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAFB gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAFB¹	--	scaffold attachment factor B	90.7(n) 93.76(a)	485028 XM_542146.2 XP_542146.2
chimpanzee (Pan troglodytes)	SAFB¹	--	scaffold attachment factor B	99.09(n) 99.23(a)	455619 XM_001142439.1 XP_001142439.1
cow (Bos taurus)	SAFB¹	--	scaffold attachment factor B	82.7(n) 81.96(a)	539785 XM_589446.3 XP_589446.3
rat (Rattus norvegicus)	Safb¹	--	scaffold attachment factor B	81.13(n) 84.75(a)	64196 NM_022394.1 NP_071789.1
mouse (Mus musculus)	Safb^{1, 5}	17⁵	scaffold attachment factor B^{1, 5}	82.69(n)¹ 86.52(a)¹	224903¹ XM_001480312.1¹ XP_001480362.1¹ AK014067⁵ AK019904⁵ (see all 11)

About this table Species with no ortholog for SAFB

ENSEMBL Gene Tree for SAFB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SAFB gene

SAFB2² SLTM²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/177 NCBI SNPs in SAFB are shown (see all 177 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10407593^1,2	A	5619597(+)	`ttattA/Tttttt`	1	--	ng3¹		0	--	--	--	--
	rs11542075^1,2	H	5605163(+)	`ACCAAG/CATGAT`	1	H/D	mis¹ ese³		4		EU EA WA	406
	rs2485257^1,2	A,C,F,H,O	5606792(-)	`TTTCCG/ATTTTC`	1	--	int¹		7		EU EA WA NA	558
	rs2485274^1,2	C,F,H,O	5586311(+)	`CAATAC/TGCAGT`	1	--	int¹		7		EU EA WA NA	560
	rs7251363^1,2	A,C,F,H	5595149(+)	`tgagaA/Gcacaa`	1	--	int¹		4		EU EA WA	410
	rs4807047^1,2	A,C,F,H	5606882(+)	`GTACCG/AGAAGT`	1	--	int¹		4		EU EA WA	420
	rs2002985^1,2	A,C,F,H	5617182(+)	`AGAAAA/GAACAG`	1	--	int¹ trp³		8		EU EA WA	834
	rs4239608^1,2	A,C,F,H	5580583(+)	`CATCAG/CTCTTT`	1	--	int¹		7		EU EA WA NA	556
	rs10518245^1,2	A,C,F,H	5576802(+)	`GGTTGC/AGAATG`	1	--	int¹		13		NS EU EA WA	938
	rs7256359^1,2	A,C,F,H	5595374(+)	`ATGAAC/TTAAGC`	1	--	int¹		7		EU EA WA NA	554

About this table

HapMap Linkage Disequilibrium images for SAFB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602895

9 Novoseek disease relationships for SAFB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hydatids	20.93	1	7517028 (1)
cysticercosis	9.77	1	10391846 (1)
leukemia	4.27	1	7537740 (1)
breast cancer	1.34	10	19077293 (2), 12660241 (1), 14587024 (1)
shock	0.00	9	10212141 (3), 11058091 (3)
tumors	0.00	3	14587024 (2), 12660241 (1)
glioblastoma	0.00	1	9444363 (1)
breast carcinoma	0.00	1	7506422 (1)
osteosarcoma	0.00	1	10648616 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/243 PubMed articles for SAFB gene (see all 243 ):

Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA. (PubMed id 8600450)^{1, 2, 3, 4} Renz A. and Fackelmayer F.O. (1996)
SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PubMed id 12660241)^{1, 3, 4} Townson S.M.... Oesterreich S. (2003)
SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements. (PubMed id 9671816)^{1, 3, 4} Nayler O.... Stamm S. (1998)
Assignment of SAFB encoding Hsp27 ERE-TATA binding protein (HET)/scaffold attachment factor B (SAF-B) to human chromosome 19 band p13. (PubMed id 9605873)^{1, 2, 3} DuPont B.R....Oesterreich S. (1997)
Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells. (PubMed id 9328833)^{1, 3, 4} Oesterreich S....Fuqua S.A.W. (1997)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock. (PubMed id 10212141)^{1, 3} Weighardt F....Biamonti G. (1999)
Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity. (PubMed id 16326836)^{1, 3} Debril M.B....Gelman L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6294	HGNC: 10520	AceView: SAFB	Ensembl:ENSG00000160633	euGenes: HUgn6294
ECgene: SAFB	H-InvDB: SAFB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SAFB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SAFB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SAFB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAFB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAFB		Antibodies for SAFB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAFB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SAFB)
	Antibodies (SAFB)
	Chimera RNAi (SAFB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (SAFB)
	Antibodies (SAFB)

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Antibodies for SAFB

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SAFB Gene at Home site.
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SAFB Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SAFB

Summaries
for SAFB

Genomic Location
for SAFB

Proteins
for SAFB

Protein Domains/
Families
for SAFB

Gene Function
for SAFB

Pathways & Interactions
for SAFB

Drugs & Compounds
for SAFB

Transcripts
for SAFB

Expression
for SAFB

Orthologs
for SAFB

Paralogs
for SAFB

SNPs/Variants
for SAFB

Disorders & Mutations
for SAFB

Medical News
for SAFB

Publications
for SAFB

Search for SAFB

Genome Databases showing SAFB

Other Databases showing SAFB

Specialized Databases showing SAFB

Licensable Technologies
for SAFB

Services
for SAFB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAFB Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SAFB

Summariesfor SAFB

Genomic Locationfor SAFB

Proteinsfor SAFB

Protein Domains/Familiesfor SAFB

Gene Functionfor SAFB

Pathways & Interactionsfor SAFB

Drugs & Compoundsfor SAFB

Transcriptsfor SAFB

Expression for SAFB

Orthologsfor SAFB

Paralogsfor SAFB

SNPs/Variantsfor SAFB

Disorders & Mutationsfor SAFB

Medical Newsfor SAFB

Publicationsfor SAFB

Search for SAFB

Genome Databases showing SAFB

Other Databases showing SAFB

Specialized Databases showing SAFB

Licensable Technologiesfor SAFB

Servicesfor SAFB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAFB

Summaries
for SAFB

Genomic Location
for SAFB

Proteins
for SAFB

Protein Domains/
Families
for SAFB

Gene Function
for SAFB

Pathways & Interactions
for SAFB

Drugs & Compounds
for SAFB

Transcripts
for SAFB

Expression
for SAFB

Orthologs
for SAFB

Paralogs
for SAFB

SNPs/Variants
for SAFB

Disorders & Mutations
for SAFB

Medical News
for SAFB

Publications
for SAFB

Licensable Technologies
for SAFB

Services
for SAFB