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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAFB Gene

protein-coding   GIFtS: 57
GCID: GC19P005574

scaffold attachment factor B
 Explore 21 diseases affiliated with
SAFB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SAFB    

Aliases
for SAFB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Scaffold Attachment Factor B1 2     HSP27 Estrogen Response Element-TATA Box-Binding Protein2 3
HET1 2 3 5     SAB-B12
SAFB11 2 3     Glutathione S-Transferase Fusion Protein2
HAP2 3     Heat-Shock Protein (HSP27) Estrogen Response Element And TATA Box-Binding
Protein2
SAF-B2 3     Hsp27 ERE-TATA Binding Protein2
SAF-B12 3     Scaffold Attachment Factor B12
HSP27 ERE-TATA-Binding Protein2 3     

External Ids:    HGNC: 105201   Entrez Gene: 62942   Ensembl: ENSG000001606337   OMIM: 6028955   UniProtKB: Q154243   
ORGUL members:         
NONCODE:n410537    

Export aliases for SAFB gene to outside databases

Previous GC identifers: GC19P005715 GC19P005563 GC19P005384


Summaries
for SAFB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SAFB:
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA
elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear
matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix
protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to
S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the
vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can
act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged
head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different
isoforms have been found for this gene.(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424
Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the
formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and
RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27
promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the
SREBF1 promoter (By similarity). Can inhibit cell proliferation

Gene Wiki entry for SAFB


Genomic Views
for SAFB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAFB gene promoter:
         C/EBPbeta   Pax-5   Sp1   Pax-2   Pax-2a   CUTL1   FAC1   Zic3   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SAFB promoter sequence
   Search SABiosciences Chromatin IP Primers for SAFB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAFB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3-p13.2

SAFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAFB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P005574:  view genomic region     (about GC identifiers)

Start:
 5,623,046 bp from pter      End:
 5,668,489 bp from pter
Size:
 45,444 bases      Orientation:
 plus strand

Proteins
for SAFB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424 (See protein sequence)
Recommended Name: Scaffold attachment factor B1  
Size: 915 amino acids; 102642 Da
Subunit: Monomer. Can form homodimers. Interacts with KHDRBS3, POLR2A, SAFB2 or SFRS1, SFRS9 and TRA2B/SFRS10 (By
similarity). Interacts with isoform 1 and isoform 2 of SRPK1 and inhibits its activity. Interacts with RBMX (By
similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92017.1; Type=Erroneous initiation;
Secondary accessions: B7Z5B6 F5H0H3 O60406 Q59HH8
Alternative splicing: 2 isoforms:  Q15424-1   Q15424-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SAFB: NX_Q15424

Post-translational modifications:

  • Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional
    • repressor activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15424

    • SAFB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001188267.1  NP_001188268.1  NP_001188269.1  NP_002958.2  

    ENSEMBL proteins: 
     ENSP00000468543   ENSP00000292123   ENSP00000464840   ENSP00000415895   ENSP00000467423  
     ENSP00000464758   ENSP00000438880   ENSP00000404545  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SAFB

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    SAFB for ontologies           About GeneDecksing



    SAFB Antibody Products: 
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    ThermoFisher Antibodies for SAFB

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    Uscn ELISAs and CLIAs for SAFB

    Protein Domains /
    Families
    for SAFB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SAFB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003034 SAP_dom
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q15424

    ProtoNet protein and cluster: Q15424

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB003034 DNA-binding SAP


    UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 SAP domain


    Function
    for SAFB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424
    Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the
    formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and
    RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27
    promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the
    SREBF1 promoter (By similarity). Can inhibit cell proliferation

         Genatlas biochemistry entry for SAFB:
    scaffold attachment factor B,97kDa,ubiquitously expressed protein (hsp27 promoter binding-protein)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAFB
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SAFB (see all 13):
    hsa-miR-187* hsa-miR-520d-5p hsa-miR-922 hsa-miR-130a* hsa-miR-183 hsa-miR-23c hsa-miR-885-3p hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SAFB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SAFB (see all 4)
    OriGene shRNA RFP: SAFB
    OriGene siRNA: SAFB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAFB

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAFB 

    Cell Line
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    Search LifeMap BioReagents cell lines for SAFB

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001047core promoter binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003682chromatin binding IEA--
    GO:0003690double-stranded DNA binding TAS1324173


    SAFB for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for SAFB:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Safbtm1So for SAFB
         11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Safb):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  liver/biliary system  mortality/aging  reproductive system  respiratory system 
     skeleton 

    SAFB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SAFB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    		Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SAFB
        Epithelial Tight Junctions


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAFB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for SAFB (Q154241, 2, 3 ENSP000002921234) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958702, 3, ENSP000003792824MINT-62607 MINT-62705 MINT-62781 I2D: score=5 STRING: ENSP00000379282
    CHD3Q128732, 3MINT-64244 I2D: score=5 
    MAP1LC3BQ9GZQ82, 3MINT-8259741 I2D: score=4 
    SRPK1Q96SB42, 3, ENSP000003910694MINT-7228207 MINT-7228500 MINT-7228466 MINT-7228438 I2D: score=2 STRING: ENSP00000391069
    TP53P046372, ENSP000002693054MINT-8072012 MINT-8072038 MINT-8074581 MINT-8074790 MINT-8072027 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS1324173
    GO:0006351transcription, DNA-dependent IEA--
    GO:0030520intracellular estrogen receptor signaling pathway IEA--
    GO:0040007growth IEA--
    GO:0042445hormone metabolic process IEA--


    SAFB for ontologies           About GeneDecksing



    Drugs & Compounds
    for SAFB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SAFB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAFB
    10/31 Novoseek chemical compound relationships for SAFB gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 58.1 22 8943314 (1), 1334490 (1), 17942635 (1), 9886379 (1) (see all 18)
    phosphotyrosine 50.9 3 8619495 (1), 10749687 (1), 8188688 (1)
    gdp 48.3 3 16138900 (1), 7513052 (1), 11073942 (1)
    phosphatidylinositol 45.8 6 8603102 (1), 8413261 (1), 8058768 (1), 8388538 (1) (see all 5)
    serine 41.7 5 9030663 (1), 15192100 (1), 11118435 (1), 9671816 (1)
    gtp 32.6 4 16138900 (1), 17995937 (1), 8940119 (1)
    zinc 18 11 7782343 (1), 18760786 (1), 8521965 (1), 8300628 (1) (see all 9)
    atp 17.8 5 8608138 (1), 10510297 (1), 16621795 (1), 12511576 (1) (see all 5)
    alanine 15 2 7592773 (1), 7923583 (1)
    cysteine 13.7 1 8300628 (1)

    Search CenterWatch for drugs/clinical trials and news about SAFB / SAFB1 

    Transcripts
    for SAFB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SAFB gene (4 alternative transcripts): 
    NM_001201338.1  NM_001201339.1  NM_001201340.1  NM_002967.3  

    Unigene Cluster for SAFB:

    Scaffold attachment factor B
    Hs.728802  [show with all ESTs]
    Unigene Representative Sequence: NM_001201338
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589863 ENST00000591666 ENST00000292123 ENST00000592224 ENST00000586934
    ENST00000454510 ENST00000588852 ENST00000590485 ENST00000592707 ENST00000592396
    ENST00000589006 ENST00000586281 ENST00000591991 ENST00000592555 ENST00000538656
    ENST00000433404(uc010xiq.2 uc002mcf.3 uc002mcg.3 uc002mce.4 uc010xis.2 uc010xit.2 uc010xir.2 uc010xiu.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAFB
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SAFB (see all 13):
    hsa-miR-187* hsa-miR-520d-5p hsa-miR-922 hsa-miR-130a* hsa-miR-183 hsa-miR-23c hsa-miR-885-3p hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SAFB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SAFB (see all 4)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB208780.1 AK095736.1 AK290444.1 AK293152.1 AK294671.1 AK294718.1 AK295298.1 AK298707.1 
    AK299525.1 AK304474.1 AK307970.1 BC020309.1 BC032055.1 BC126219.1 BC143937.1 BC143938.1 
    BC143939.1 L43631.1 NR_037699.1 U72355.1 

    22 DOTS entries:

    DT.97820339  DT.92450357  DT.450237  DT.100705744  DT.95200171  DT.100811853  DT.100000471  DT.92450343 
    DT.95284311  DT.100059666  DT.40234561  DT.95363107  DT.102836891  DT.121455441  DT.121455473  DT.121455485 
    DT.86838544  DT.95154079  DT.95363086  DT.91879950  DT.95345451  DT.99953773 

    24/574 AceView cDNA sequences (see all 574):

    BQ058423 AI246343 CB111505 BF056258 AW292171 AI989953 BF437609 BF002280 
    AI200303 AI660080 AA806647 BU507232 AI199437 AA227930 CA394423 BQ061663 
    BF111831 CA502832 BQ941148 AU130877 BQ958602 Z45303 BP355327 CA395703 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SAFB (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ·
    SP1:                                                  -     -     -                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -     -     -     -     -     -     -                                                                                             

    ExUns: 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SAFB

    Expression
    for SAFB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAFB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGGCGGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SAFB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAFB

    SOURCE GeneReport for Unigene cluster: Hs.728802

    UniProtKB/Swiss-Prot: SAFB1_HUMAN, Q15424
    Tissue specificity: Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide
    number of breast cancer cell lines

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    Orthologs
    for SAFB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SAFB gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Safb1 , 5 scaffold attachment factor B1, 5 82.73(n)1
    86.64(a)1    		   17 (29.40 cM)5
    2249031  NM_001163300.11  NP_001156772.11 
     565849825 
    chicken
    (Gallus gallus)    		 Aves SAFB21 scaffold attachment factor B2 70.82(n)
    67.26(a)    		   426047  XM_423726.3  XP_423726.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 52(a)
    51(a)
    		 many ↔ many
    many ↔ many
    		 GL343717.1(9708-34142)
    GL343717.1(44007-85821)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.29182 Danio rerio mRNA similar to scaffold attachment factor more 76.42(n)    BC044153.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG73586
    Saf-B6
    		 Scaffold attachment factor B
    		 5(a)
    20(a)
    		 possible ortholog
    many → 1
    		 X(18783043-18787666)
    3R(20643186-20648072)
    worm
    (Caenorhabditis elegans)    		 Secernentea F32B4.46
    		 Protein F32B4.4, isoform a
    		 13(a)
    		 possible ortholog
    		 I(11517557-11526553)


    ENSEMBL Gene Tree for SAFB (if available)
    TreeFam Gene Tree for SAFB (if available) 

    Paralogs
    for SAFB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAFB gene
    SAFB22  SLTM2  
    4 SIMAP similar genes for SAFB using alignment to 8 protein entries:     SAFB1_HUMAN (see all proteins):
    DKFZp779C1727    SAFB2    SLTM    HNRNPD

    SAFB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SAFB
    PGOHUM00000242911


    Genomic Variants
    for SAFB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/778 NCBI SNPs in SAFB are shown (see all 778)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1155756991,2
    		--5621155(+) TGCCCT/CTGACA 6 -- us2k1 int11Minor allele frequency- C:0.01WA 118
    rs1871898261,2
    		--5621216(+) ACCGAA/GTACCA 6 -- us2k1 int10--------
    rs1924995011,2
    		--5621241(+) GCCTAC/GAAGGC 6 -- us2k1 int10--------
    rs2019150851,2
    		C,--5621414(+) TATTAG/AGGAGA 6 -- int1 us2k11Minor allele frequency- A:0.00EU 1317
    rs2011039261,2
    		--5621425(+) GATGAC/GTTTTA 6 -- us2k1 int10--------
    rs1426804561,2
    		--5621526(+) ACTCCA/GGGTCA 6 -- us2k1 int10--------
    rs1838230571,2
    		--5621565(+) GAGGAA/GGAACC 6 -- us2k1 int10--------
    rs1862229621,2
    		--5621625(+) TGTGAA/GCAGGA 6 -- us2k1 int10--------
    rs1905295291,2
    		--5621626(+) GTGAGC/TAGGAG 6 -- us2k1 int10--------
    rs1473355421,2
    		--5621630(+) GCAGGA/CGCTCC 6 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for SAFB (5623046 - 5668489 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SAFB: --

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    Disorders / Diseases
    for SAFB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SAFB for disorders           About GeneDecksing

    OMIM gene information: 602895    OMIM disorders: --

    20/21 diseases for SAFB (see all 21):    About MalaCards
    denys-drash syndrome    cysticercosis    oral squamous cell carcinoma    acute promyelocytic leukemia
    squamous cell carcinoma    hepatitis e    intrahepatic cholangiocarcinoma    familial breast cancer
    breast cancer    huntington's disease    cholangiocarcinoma    osteosarcoma
    encephalomyelitis    gout    carcinoma    cardiomyopathy
    leukemia    hepatitis    cerebritis    immunodeficiency

    10 Novoseek disease relationships for SAFB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydatids 19.6 1 7517028 (1)
    cysticercosis 8.49 1 10391846 (1)
    breast cancer 4.31 14 19137425 (3), 19077293 (2), 12660241 (1), 14587024 (1)
    leukemia 4.3 1 7537740 (1)
    cancer 2.43 2 20014070 (1)
    breast carcinoma 0 1 7506422 (1)
    shock 0 9 10212141 (3), 11058091 (3)
    glioblastoma 0 1 9444363 (1)
    osteosarcoma 0 1 10648616 (1)
    tumors 0 5 14587024 (2), 12660241 (1), 19137425 (1)

    Human Genome Epidemiology (HuGE) Navigator: SAFB (1 document)

    Export disorders for SAFB gene to outside databases

    Publications
    for SAFB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAFB gene, integrated from 9 sources (see all 282):
    (articles sorted by number of sources associating them with SAFB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA. (PubMed id 8600450)1, 2, 3, 9 Renz A. and Fackelmayer F.O. (1996)
    2. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PubMed id 12660241)1, 2, 9 Townson S.M.... Oesterreich S. (2003)
    3. SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements. (PubMed id 9671816)1, 2, 9 Nayler O.... Stamm S. (1998)
    4. The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. (PubMed id 19674106)1, 2, 9 Tsianou D....Georgatsou E. (2009)
    5. Assignment of SAFB encoding Hsp27 ERE-TATA binding protein (HET)/scaffold attachment factor B (SAF-B) to human chromosome 19 band p13. (PubMed id 9605873)1, 3, 9 DuPont B.R....Oesterreich S. (1997)
    6. Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B. (PubMed id 11509566)1, 2, 9 Nikolakaki E....Giannakouros T. (2001)
    7. Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells. (PubMed id 9328833)1, 2, 9 Oesterreich S....Fuqua S.A.W. (1997)
    8. Co-repressor activity of scaffold attachment factor B 1 requires sumoylation. (PubMed id 21527249)1, 2 Garee J.P....Oesterreich S. (2011)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    External Searches for SAFB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SAFB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6294 HGNC: 10520 AceView: SAFB Ensembl:ENSG00000160633 euGenes: HUgn6294
    ECgene: SAFB H-InvDB: SAFB

    Other Databases showing SAFB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SAFB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAFB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAFB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SAFB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SAFB gene:
    Search GeneIP for patents involving SAFB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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