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SAE1 Gene

protein-coding GIFtS: 63

GC19P052328

SUMO1 activating enzyme subunit 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AOS1 ^¹, ², ³
FLJ3091 ^¹, ²
HSPC140 ^²
SUA1 ^², ³
Sua1 ^¹
UBLE1A ^², ³

Descriptions
SUMO-1 activating enzyme E1 N subunit ^²
SUMO-1 activating enzyme subunit 1 ^²
SUMO1 activating enzyme subunit 1 ^²
Ubiquitin-like 1-activating enzyme E1A ^², ³
activator of SUMO1 ^²
sentrin/SUMO-activating protein AOS1 ^²
ubiquitin-like protein SUMO-1 activating enzyme ^²

External Ids
HGNC: 30660¹
Entrez Gene: 10055²
UniProtKB: Q9UBE0³
Ensembl: ENSG00000142230⁷

Search outside databases for aliases for SAE1 gene

Previous GC identifers: GC19P048277 GC19P048024 GC19P052310 GC19P052326 GC19P052327

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SAE1_HUMAN, Q9UBE0

Function: The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It

mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved

cysteine residue on SAE2

Gene Wiki entry for SAE1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAE1 gene

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

SAE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P052328: (about GC identifiers)

Start:	52,325,984 bp from pter
End:	52,405,372 bp from pter
Size:	79,389 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAE1_HUMAN, Q9UBE0 (See protein sequence)

Recommended Name: SUMO-activating enzyme subunit 1

Size: 346 amino acids; 38450 Da

Subunit: Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1Y8Q (3D)

1Y8R (3D)

Secondary accessions: O95717 Q9P020

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001139185.1 NP_001139186.1 NP_005491.1

ENSEMBL proteins:

ENSP00000270225

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SAE1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for SAE1
	Recombinant Proteins from Abcam (AOS1+UBA2, SAE1 )
	Human Recombinant Proteins from Abnova (SAE1)

OriGene Purified Recombinant Human Protein: SAE1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	10187858

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Antibodies for SAE1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SAE1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AOS1+UBA2, SAE1 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SAE1)
	Novus Biologicals Antibodies for SAE1

Assays for SAE1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for SAE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UBE0

ProtoNet protein and cluster: Q9UBE0

1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold

UniProtKB/Swiss-Prot: SAE1_HUMAN, Q9UBE0

Similarity: Belongs to the ubiquitin-activating E1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAE1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAE1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_005500

Applied Biosystems Silencer® siRNAs for SAE1

Sigma-Aldrich siRNA and siRNA Panels for SAE1

Sigma-Aldrich shRNA for SAE1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SAE1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001145713
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001145713
untagged cDNA clones in CMV expression vector (see all 4): NM_001145713

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016402

UniProtKB/Swiss-Prot: SAE1_HUMAN, Q9UBE0

Function: The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It

mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved

cysteine residue on SAE2

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004839	ubiquitin activating enzyme activity	TAS	10187858
GO:0008022	protein C-terminus binding	ISS	--
GO:0008047	enzyme activator activity	TAS	9920803
GO:0016874	ligase activity	IEA	--
GO:0043008	ATP-dependent protein binding	IDA	10187858

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SAE1_HUMAN, Q9UBE0

Pathway: Protein modification; protein sumoylation

Gene Network Central^TM Interacting Genes and Proteins Network for SAE1

5/14 Interacting proteins for SAE1 (Q9UBE0^{1, 2} ENSP00000270225³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2I	P63279¹, ENSP00000348056³	EBI-743154, EBI-80168 STRING (score=.86)
UBA2	Q9UBT2¹^,², ENSP00000246548³	EBI-743154, EBI-718569 MINT-66320 EBI-743154, EBI-718569 MINT-66320 STRING (score=.999)
CYP1B1	Q16678¹	EBI-743154, EBI-1055133
FKBP4	Q02790¹	EBI-743154, EBI-1047444
SUMO3	P55854¹	EBI-743154, EBI-474067

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	IEA	--
GO:0008152	metabolic process	IEA	--
GO:0016567	protein ubiquitination	TAS	10187858
GO:0019941	modification-dependent protein catabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAE1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAE1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAE1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_005500

Sigma-Aldrich siRNA and siRNA Panels for SAE1

Sigma-Aldrich shRNA for SAE1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005500

REFSEQ mRNAs for SAE1 gene (3 alternative transcripts):

NM_001145713.1 NM_001145714.1 NM_005500.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005500

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001145713
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001145713
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001145713

Additional cDNA sequence:

AF046025.2 AF090385.2 AF110956.1 AF161489.1 AK021978.1 AK055481.1 AK090645.1 AK302287.1

AK315624.1 BC000344.2 BC003611.2 BC018271.1 BC128518.1 BC128519.1 BT007290.1 BX538265.1

CR599343.1 CR611635.1 CR612586.1 CR622180.1 CR625745.1

24/38 DOTS entries (see all 38 ):

DT.456192 DT.100880224 DT.85105605 DT.95334267 DT.100880225 DT.100690136 DT.100880210 DT.100880216

DT.100880214 DT.110612 DT.100880218 DT.100880211 DT.121498604 DT.92461230 DT.100880222 DT.100880215

DT.100880219 DT.91713187 DT.100880221 DT.121498524 DT.75145118 DT.95334254 DT.121498618 DT.97860556

24/739 AceView cDNA sequences (see all 739 ):

AI953980 AK027595 AA814452 CR622180 BG257249 BQ670034 BU167165 BQ424728

BP350080 BM463629 BM558971 CB130925 BU169863 BM466569 BQ425441 BF795459

BM759563 BQ642133 AL552980 AA309709 BQ065448 BM459569 BM720217 AA604261

highest scoring ESTs for SAE1:

AI339364 H98166 AA024484 AA056429 AA081326 AA081347 AA090691 AA130880 AA130935 AA132698

Unigene Cluster for SAE1:

SUMO1 activating enzyme subunit 1

Hs.515500 [show with all ESTs]

Unigene Representative Sequence: BX538265

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SAE1 (see all 10 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	·	14d	·	14e
SP1:							-		-																-				-
SP2:							-		-														-		-				-
SP3:									-														-		-				-
SP4:																							-		-		-		-
SP5:							-		-														-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for SAE1

1 Ensembl transcript including schematic representation:

ENST00000270225

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAE1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAE1

¹ / ² / ³

5 probe-sets matching SAE1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45712_at²^{, 3}	U95-B	1	1.00	1.00	0.81	1.24	H98166	1.00	1.00	1.00	1
51084_at²^{, 3}	U95-C	1	1.00	1.00	0.96	0.76	AI339364	1.00	1.00	1.00	1
217946_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016402	0.20	1.00	0.72	1
217946_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555618_s_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

GeneDecks SAE1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGGCTCAAGT

SOURCE GeneReport for Unigene cluster: Hs.515500
UniProtKB/Swiss-Prot: SAE1_HUMAN, Q9UBE0
Tissue specificity: Expression level increases during S phase and drops in G2 phase (at protein
level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAE1 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAE1¹	--	SUMO1 activating enzyme subunit 1	92.1(n) 96.24(a)	476425 XM_533632.2 XP_533632.1
chimpanzee (Pan troglodytes)	SAE1¹	--	SUMO1 activating enzyme subunit 1	99.71(n) 100(a)	456159 XM_512777.2 XP_512777.2
cow (Bos taurus)	SAE1¹	--	SUMO1 activating enzyme subunit 1	91.4(n) 96.52(a)	505512 XM_581807.3 XP_581807.2
rat (Rattus norvegicus)	Sae1¹	--	SUMO1 activating enzyme subunit 1	86.71(n) 92.2(a)	308384 NM_001012063.1 NP_001012063.1
mouse (Mus musculus)	Sae1^{1, 5}	7 (4.00 cM)⁵	SUMO1 activating enzyme subunit 1^{1, 5}	87.57(n)¹ 93.35(a)¹	56459¹ NM_019748.2¹ NP_062722.1¹ AB024303⁵ AK010313⁵ (see all 20)

About this table Species with no ortholog for SAE1

ENSEMBL Gene Tree for SAE1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SAE1 gene

NAE1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/346 NCBI SNPs in SAE1 are shown (see all 346 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8100413^1,2	A,C,F,H	52325492(+)	`gttcaA/Gtgtca`	1	--	ng5¹		4		EU EA WA	396
--	rs11559276^1,2	H	52350261(+)	`GCCCGA/GCACCA`	1	D/G	mis¹ ese³		4		EU EA WA	406
	rs1644750^1,2	H	52325927(+)	`GCGCAG/CAAGCA`	1	--	ng5¹		4		EU EA WA	390
--	rs1644747^1,2	C	52324970(+)	`gtgcaA/Gaggca`	1	--	ng5¹		0	--	--	--	--
	rs578258^1,2	H	52325280(+)	`tgtgtT/Gcattt`	1	--	ng5¹ tfbs³		4		EU EA WA	404
	rs1644749^1,2	H	52325901(+)	`GCGCAG/CGCGTG`	1	--	ng5¹		4		EU EA WA	420
	rs473112^1,2	H	52325832(+)	`ATGCAG/CTCGCC`	1	--	ng5¹		5		MN EU EA WA	602
	rs11083864^1,2	C,H	52392451(+)	`CCTGAC/TCTGCT`	1	D/D	syn¹ ese³		6		EU EA WA NA	602
--	rs4533393^1,2	H	52345388(+)	`GCTCAG/AAATCT`	1	Q/Q	syn¹ ese³		4		EU EA WA	418
	rs309182^1,2	A,C,F,H,O	52354556(+)	`agtgtC/Gtagca`	1	--	int¹		7		EU EA WA NA	562

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HapMap Linkage Disequilibrium images for SAE1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/21 PubMed articles for SAE1 gene (see all 21 ):

Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. (PubMed id 10217437)^{1, 2, 3, 4} Gong L....Yeh E.T. (1999)
In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. (PubMed id 9920803)^{1, 2, 3, 4} Okuma T....Yasuda H. (1999)
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. (PubMed id 10187858)^{2, 3, 4} Desterro J.M.P.... Hay R.T. (1999)
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. (PubMed id 16620772)^{3, 4} Li T....Chock P.B. (2006)
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. (PubMed id 15660128)^{3, 4} Lois L.M. and Lima C.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PubMed id 11451954)^{3, 4} Tatham M.H.... Hay R.T. (2001)
Expression and regulation of the mammalian SUMO-1 E1 enzyme. (PubMed id 11481243)^{3, 4} Azuma Y....Dasso M. (2001)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{3, 4} Zhang Q.H....Chen Z. (2000)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10055	HGNC: 30660	AceView: SAE1	Ensembl:ENSG00000142230	euGenes: HUgn10055
ECgene: SAE1	H-InvDB: SAE1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for SAE1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SAE1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAE1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAE1		Antibodies for SAE1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAE1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SAE1)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (AOS1+UBA2, SAE1 )

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for SAE1

	Assays/Proteins for SAE1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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SAE1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for SAE1

Summaries
for SAE1

Genomic Location
for SAE1

Proteins
for SAE1

Protein Domains/
Families
for SAE1

Gene Function
for SAE1

Pathways & Interactions
for SAE1

Drugs & Compounds
for SAE1

Transcripts
for SAE1

Expression
for SAE1

Orthologs
for SAE1

Paralogs
for SAE1

SNPs/Variants
for SAE1

Disorders & Mutations
for SAE1

Medical News
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Publications
for SAE1

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Genome Databases showing SAE1

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Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAE1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor SAE1

Summariesfor SAE1

Genomic Locationfor SAE1

Proteinsfor SAE1

Protein Domains/Familiesfor SAE1

Gene Functionfor SAE1

Pathways & Interactionsfor SAE1

Drugs & Compoundsfor SAE1

Transcriptsfor SAE1

Expression for SAE1

Orthologsfor SAE1

Paralogsfor SAE1

SNPs/Variantsfor SAE1

Disorders & Mutationsfor SAE1

Medical Newsfor SAE1

Publicationsfor SAE1

Search for SAE1

Genome Databases showing SAE1

Other Databases showing SAE1

Specialized Databases showing SAE1

Licensable Technologiesfor SAE1

Servicesfor SAE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAE1

Summaries
for SAE1

Genomic Location
for SAE1

Proteins
for SAE1

Protein Domains/
Families
for SAE1

Gene Function
for SAE1

Pathways & Interactions
for SAE1

Drugs & Compounds
for SAE1

Transcripts
for SAE1

Expression
for SAE1

Orthologs
for SAE1

Paralogs
for SAE1

SNPs/Variants
for SAE1

Disorders & Mutations
for SAE1

Medical News
for SAE1

Publications
for SAE1

Licensable Technologies
for SAE1

Services
for SAE1