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Aliases for SACM1L Gene

Aliases for SACM1L Gene

  • SAC1 Suppressor Of Actin Mutations 1-Like (Yeast) 2 3
  • Suppressor Of Actin Mutations 1-Like Protein 3 4
  • KIAA0851 4 6
  • SAC1 3 6
  • Phosphatidylinositide Phosphatase SAC1 3
  • Suppressor Of Actin 1 3
  • EC 63
  • EC 63
  • EC 3.1.3.- 4
  • EC 3.1.3 63

External Ids for SACM1L Gene

Previous GeneCards Identifiers for SACM1L Gene

  • GC03P044971
  • GC03P045550
  • GC03P045691
  • GC03P045706

Summaries for SACM1L Gene

GeneCards Summary for SACM1L Gene

SACM1L (SAC1 Suppressor Of Actin Mutations 1-Like (Yeast)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphatase activity and phosphatidylinositol-4-phosphate phosphatase activity. An important paralog of this gene is INPP5F.

UniProtKB/Swiss-Prot for SACM1L Gene

  • Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity).

Gene Wiki entry for SACM1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SACM1L Gene

Genomics for SACM1L Gene

Regulatory Elements for SACM1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SACM1L Gene

45,689,056 bp from pter
45,745,424 bp from pter
56,369 bases
Plus strand

Genomic View for SACM1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SACM1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SACM1L Gene

Proteins for SACM1L Gene

  • Protein details for SACM1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositide phosphatase SAC1
    Protein Accession:
    Secondary Accessions:
    • A8K527
    • B4DK71
    • O94935
    • Q7LA14
    • Q7LA22
    • Q96AX7
    • Q9NQ46
    • Q9NQ57

    Protein attributes for SACM1L Gene

    587 amino acids
    Molecular mass:
    66967 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74874.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SACM1L Gene


neXtProt entry for SACM1L Gene

Proteomics data for SACM1L Gene at MOPED

Post-translational modifications for SACM1L Gene

  • Ubiquitination at Lys250 and Lys483
  • Modification sites at PhosphoSitePlus

Other Protein References for SACM1L Gene

Antibody Products

Domains for SACM1L Gene

Gene Families for SACM1L Gene

Protein Domains for SACM1L Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAC domain.
  • Contains 1 SAC domain.
genes like me logo Genes that share domains with SACM1L: view

Function for SACM1L Gene

Molecular function for SACM1L Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity).

Enzyme Numbers (IUBMB) for SACM1L Gene

Gene Ontology (GO) - Molecular Function for SACM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004438 phosphatidylinositol-3-phosphatase activity IEA --
GO:0005515 protein binding IPI 14527956
GO:0016791 phosphatase activity ISS --
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity IEA --
GO:0042578 phosphoric ester hydrolase activity --
genes like me logo Genes that share ontologies with SACM1L: view

Phenotypes for SACM1L Gene

genes like me logo Genes that share phenotypes with SACM1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SACM1L

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SACM1L Gene

Localization for SACM1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SACM1L Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SACM1L Gene COMPARTMENTS Subcellular localization image for SACM1L gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SACM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IDA --
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
genes like me logo Genes that share ontologies with SACM1L: view

Pathways for SACM1L Gene

genes like me logo Genes that share pathways with SACM1L: view

Gene Ontology (GO) - Biological Process for SACM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SACM1L: view

Drugs for SACM1L Gene

(2) Novoseek inferred chemical compound relationships for SACM1L Gene

Compound -log(P) Hits PubMed IDs
inositol 59.6 1
atp 28.6 2

(1) PharmGKB related drug/compound annotations for SACM1L Gene

Drug/compound Annotation
bupropion Clinical Annotation
genes like me logo Genes that share compounds with SACM1L: view

Transcripts for SACM1L Gene

Unigene Clusters for SACM1L Gene

SAC1 suppressor of actin mutations 1-like (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SACM1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SACM1L Gene

No ASD Table

Relevant External Links for SACM1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SACM1L Gene

mRNA expression in normal human tissues for SACM1L Gene

Protein differential expression in normal tissues for SACM1L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Platelet (8.1), and Adrenal (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SACM1L Gene

SOURCE GeneReport for Unigene cluster for SACM1L Gene Hs.156509

mRNA Expression by UniProt/SwissProt for SACM1L Gene

Tissue specificity: Detected in heart, brain, lung, liver, kidney, pancreas and testis.
genes like me logo Genes that share expressions with SACM1L: view

Expression partners for SACM1L Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SACM1L Gene

Orthologs for SACM1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SACM1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SACM1L 35
  • 92.28 (n)
  • 94.38 (a)
  • 94 (a)
(Canis familiaris)
Mammalia SACM1L 35
  • 91.65 (n)
  • 94.38 (a)
  • 93 (a)
(Mus musculus)
Mammalia Sacm1l 35
  • 91.14 (n)
  • 95.06 (a)
Sacm1l 16
Sacm1l 36
  • 95 (a)
(Pan troglodytes)
Mammalia SACM1L 35
  • 97.79 (n)
  • 97.78 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Sacm1l 35
  • 91.43 (n)
  • 95.06 (a)
(Monodelphis domestica)
Mammalia SACM1L 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia SACM1L 36
  • 87 (a)
(Gallus gallus)
Aves SACM1L 35
  • 79.94 (n)
  • 87.07 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia SACM1L 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13854 35
(Danio rerio)
Actinopterygii sacm1lb 35
  • 70.21 (n)
  • 80.14 (a)
sacm1la 36
  • 78 (a)
sacm1lb 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sac1 37
  • 47 (a)
Sac1 35
  • 51.64 (n)
  • 48.25 (a)
Sac1 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000891 35
  • 50.03 (n)
  • 44.73 (a)
(Caenorhabditis elegans)
Secernentea F30A10.6 37
  • 45 (a)
sac-1 35
  • 54.5 (n)
  • 48.15 (a)
sac-1 36
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER447C 35
  • 46.35 (n)
  • 38.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14388g 35
  • 46.71 (n)
  • 36.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC1 35
  • 47.52 (n)
  • 38.04 (a)
SAC1 36
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RHD4 35
  • 46.9 (n)
  • 36.67 (a)
(Oryza sativa)
Liliopsida Os11g0309000 35
  • 46.53 (n)
  • 35.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7050 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00896 35
  • 46.34 (n)
  • 40.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC19F5.03 35
  • 48.34 (n)
  • 38.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2353 36
  • 49 (a)
Species with no ortholog for SACM1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SACM1L Gene

Gene Tree for SACM1L (if available)
Gene Tree for SACM1L (if available)

Paralogs for SACM1L Gene

Paralogs for SACM1L Gene

(1) SIMAP similar genes for SACM1L Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SACM1L: view

Variants for SACM1L Gene

Sequence variations from dbSNP and Humsavar for SACM1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7649736 -- 45,745,389(+) AAAAT(A/G)AAATG utr-variant-3-prime
rs12633747 -- 45,698,807(+) CTGTC(A/G)CCAGC intron-variant
rs12633158 -- 45,715,059(+) ttgta(A/G)ctaag intron-variant
rs12631951 -- 45,708,488(+) actta(G/T)gataa intron-variant
rs12629646 -- 45,745,760(+) catgc(A/G)gaact downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SACM1L Gene

Variant ID Type Subtype PubMed ID
esv34130 CNV Loss 18971310
nsv876734 CNV Gain 21882294
esv33645 CNV Loss 17666407
nsv819738 CNV Gain 19587683
nsv876735 CNV Loss 21882294
esv2554417 CNV Deletion 19546169
esv1993720 CNV Deletion 18987734
esv2725224 CNV Deletion 23290073
esv2671340 CNV Deletion 23128226
esv1482139 CNV Deletion 17803354

Relevant External Links for SACM1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SACM1L Gene

Disorders for SACM1L Gene

Relevant External Links for SACM1L

Genetic Association Database (GAD)

No disorders were found for SACM1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SACM1L Gene

Publications for SACM1L Gene

  1. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. (PMID: 11352561) Kiss H. … Dumanski J.P. (Genomics 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. (PMID: 14527956) Rohde H.M. … Boehmelt G. (J. Biol. Chem. 2003) 3 23
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 48

Products for SACM1L Gene

Sources for SACM1L Gene

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