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Aliases & Descriptions for SACM1L
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686A0231 2 | | EC 3.1.3.- 3 | | KIAA0851 1, 2, 3, 5 | | SAC1 1, 2, 5 |
| | | Descriptions |
|---|
| SAC1 suppressor of actin mutations 1-like (yeast) 2 | | Suppressor of actin mutations 1-like protein 3 | | phosphatidylinositide phosphatase SAC1 2 | | suppressor of actin 1 2 |
|
| | Search outside databases for aliases for SACM1L genePrevious GC identifers: GC03P044971 GC03P045550 GC03P045691 |
Summaries for SACM1L(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SAC1_HUMAN, Q9NTJ5Function: Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity)Gene Wiki entry for SACM1L |
Genomic Location for SACM1L
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SACM1L gene 
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3SACM1L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P045706:
(about GC identifiers)
Start:
|
45,705,893 bp from pter |
End:
|
45,761,905 bp from pter |
Size:
|
56,013 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for SACM1L
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAC1_HUMAN, Q9NTJ5 (See
protein sequence)Recommended Name: Phosphatidylinositide phosphatase SAC1 Size: 587 amino acids; 66967 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K527 O94935 Q7LA14 Q7LA22 Q96AX7 Q9NQ46 Q9NQ57REFSEQ proteins: NP_054735.3
ENSEMBL proteins: ENSP00000373713
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SACM1L: Assays for SACM1L: | Protein
Domains/ Families for SACM1L(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NTJ5
ProtoNet protein and cluster: Q9NTJ5 1 Blocks protein family: IPB002013 Synaptojanin
UniProtKB/Swiss-Prot: SAC1_HUMAN, Q9NTJ5Similarity: Contains 1 SAC domain | Gene Function for SACM1L
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014016
Applied Biosystems Silencer® siRNAs for SACM1L
Sigma-Aldrich siRNA and siRNA Panels for SACM1L  Sigma-Aldrich shRNA for SACM1L  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014016                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014016                                  untagged cDNA clone in CMV expression vector: NM_014016 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014016
UniProtKB/Swiss-Prot: SAC1_HUMAN, Q9NTJ5Function: Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity)Enzyme Number (IUBMB): EC 3.1.3.- 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0016791 | phosphatase activity |
ISS | -- | About this table | Pathways & Interactions for SACM1L
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5 Sigma-Aldrich "Your Favorite Gene" Pathways for SACM1L (Your Favorite Gene powered by Ingenuity) 
--1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for SACM1L(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SACM1L 1 Novoseek chemical compound relationship for SACM1L gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
29.35 |
2 |
10224048 (1), 14527956 (1) |
About this table
|
Transcripts for SACM1L(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014016
Sigma-Aldrich siRNA and siRNA Panels for SACM1L  Sigma-Aldrich shRNA for SACM1L  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014016 REFSEQ mRNAs for SACM1L gene: NM_014016.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014016               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014016                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014016                                  untagged cDNA clone in CMV expression vector: NM_014016  Additional cDNA sequence: AB020658.1 AK126434.1 AK291142.1 AK296421.1 AK301248.1 AL136831.1 BC016559.1 BC033581.1 CR749564.1 14 DOTS entries: DT.314635 DT.120917158 DT.100814802 DT.91832658 DT.407453 DT.100814807 DT.120917186 DT.120917201 DT.40303935 DT.95129836 DT.100814806 DT.102825572 DT.120917160 DT.120917188 24/219 AceView cDNA sequences (see all 219
):BG681793 CD625110 BG611907 BM873489 AB020658 BM806938 BM873431 AI436098 AA282650 BG260188 AA349634 BM996540 BE302313 AA669997 AA873488 AI814867 BC016559 AI188770 BC033581 CB857693 CB857401 N27587 BQ228894 CB857841
highest scoring ESTs for SACM1L:AB020658 AA115947 AA122290 AA248946 AA249382 AA282650 AA300446 AA344624 AA349633 AA382732 Unigene Cluster for SACM1L: SAC1 suppressor of actin mutations 1-like (yeast) Hs.156509 [show with all ESTs]Unigene Representative Sequence: CR749564
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000389061
|
Expression for SACM1L
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SACM1L expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SACM1L
1 / 2 / 3 3 probe-sets matching SACM1L gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACTGTATGT
SOURCE GeneReport for Unigene cluster: Hs.156509
Expression variation in blood from EXPOLDB for SACM1L UniProtKB/Swiss-Prot: SAC1_HUMAN, Q9NTJ5Tissue specificity: Detected in heart, brain, lung, liver, kidney, pancreas and testis |
Orthologs for SACM1L
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SACM1L gene from 5/20 species (see all 20
)
About this table Species with no ortholog for SACM1L
ENSEMBL Gene Tree for SACM1L | Paralogs for SACM1L(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SACM1L gene
- FIG42 INPP5F2
|
SNPs/Variants for SACM1L(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SACM1L (up to first 250kb)
|
Disorders & Mutations for SACM1L
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606569
|
Medical News for SACM1L(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SACM1L (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/17 PubMed articles for SACM1L gene (see all 17
):- The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 11352561)1, 2, 3, 4 Kiss H....Dumanski J.P. (2001)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)2, 3, 4 Nagase T....Ohara O. (1998)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. (PubMed id 14527956)1, 3 Rohde H.M....Boehmelt G. (2003)
- The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals. (PubMed id 18480408)3 Liu Y....Bankaitis V.A. (2008)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)4 Ota T....Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
- The SAC domain-containing protein gene family in Arabidopsis. (PubMed id 12805586)3 Zhong R. and Ye Z.H. (2003)
|
Search for SACM1L
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SACM1L
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SACM1L
(According to HUGE)
About This Section
| |
Specialized Databases showing SACM1L(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SACM1L(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SACM1L:

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Incremental update: 13 Oct 2009
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