Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SAC3D1 Gene

protein-coding   GIFtS: 45
GCID: GC11P064808

SAC3 Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SAC3 Domain Containing 11 2
SHD12 3
SAC3 Homology Domain-Containing Protein 12 3
HSU792662
SAC3 Domain-Containing Protein 12
Sac3 Homology Domain 12

External Ids:    HGNC: 301791   Entrez Gene: 299012   Ensembl: ENSG000001680617   UniProtKB: A6NKF13   

Export aliases for SAC3D1 gene to outside databases

Previous GC identifers: GC11P064566 GC11P061135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SAC3D1 Gene:
SAC3D1 (SAC3 domain containing 1) is a protein-coding gene. Diseases associated with SAC3D1 include pertussis, and malaria. An important paralog of this gene is MCM3AP.

UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1
Function: Involved in centrosome duplication and mitotic progression (By similarity)

Gene Wiki entry for SAC3D1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAC3D1 gene promoter:
         Brachyury   SREBP-1c   Meis-1b   Evi-1   SREBP-1b   PPAR-gamma1   SREBP-1a   PPAR-gamma2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAC3D1 promoter sequence
   Search Chromatin IP Primers for SAC3D1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAC3D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SAC3D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAC3D1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064808:  view genomic region     (about GC identifiers)

Start:
64,808,373 bp from pter      End:
64,812,300 bp from pter
Size:
3,928 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1 (See protein sequence)
Recommended Name: SAC3 domain-containing protein 1  
Size: 404 amino acids; 43553 Da
Subunit: May be part of a SHFM1-containing complex
Caution: It is uncertain whether Met-1 or Met-47 is the initiator
Sequence caution: Sequence=AP003068; Type=Erroneous gene model prediction;
Secondary accessions: A8MX08 Q99773
Alternative splicing: 2 isoforms:  A6NKF1-1   A6NKF1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SAC3D1: NX_A6NKF1

Explore proteomics data for SAC3D1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAC3D1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037431.3  
    ENSEMBL proteins: 
     ENSP00000436649   ENSP00000436704   ENSP00000381824  

    SAC3D1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SAC3D1
    OriGene Protein Over-expression Lysate for SAC3D1
    OriGene MassSpec for SAC3D1
    OriGene Custom Protein Services for SAC3D1
    GenScript Custom Purified and Recombinant Proteins Services for SAC3D1
    Novus Biologicals SAC3D1 Protein
    Novus Biologicals SAC3D1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SAC3D1

    SAC3D1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SAC3D1
    Novus Biologicals SAC3D1 Antibody
    Abcam antibodies for SAC3D1
    Cloud-Clone Corp. Antibodies for SAC3D1
    Search ThermoFisher Antibodies for SAC3D1
    Search LSBio for Antibodies for SAC3D1

    SAC3D1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAC3D1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAC3D1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAC3D1
    Cloud-Clone Corp. CLIAs for SAC3D1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR005062 SAC3/GANP/Nin1/mts3/eIF-3-p25

    Graphical View of Domain Structure for InterPro Entry A6NKF1

    ProtoNet protein and cluster: A6NKF1

    UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1
    Similarity: Belongs to the SAC3 family


    SAC3D1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAC31_HUMAN, A6NKF1
    Function: Involved in centrosome duplication and mitotic progression (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    SAC3D1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SAC3D1:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sac3d1):
     hematopoietic system  immune system 

    SAC3D1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sac3d1tm1Hnaka for SAC3D1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAC3D1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SAC3D1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAC3D1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAC3D1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SAC3D1:
    hsa-mir-1 (MIRT001337), hsa-mir-423-3p (MIRT042620)

    Block miRNA regulation of human, mouse, rat SAC3D1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SAC3D1:
    hsa-miR-330-5p hsa-miR-326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SAC3D1
    Predesigned siRNA for gene silencing in human, mouse, rat SAC3D1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAC3D1

    Clone
    Products:
         
    OriGene clones in human, mouse for SAC3D1 (see all 6)
    OriGene ORF clones in mouse, rat for SAC3D1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAC3D1 (NM_013299)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAC3D1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SAC3D1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAC3D1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SAC3D1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAC3D1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SAC31_HUMAN, A6NKF1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity).
    Cytoplasm, cytoskeleton, spindle (By similarity). Note=Localizes on centrosomes in interphase cells and at
    spindles in mitosis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IEA--
    GO:0005819spindle IEA--
    GO:0015630microtubule cytoskeleton ----

    SAC3D1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAC3D1
    Interactions:

        Search GeneGlobe Interaction Network for SAC3D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SAC3D1 (ENSP000003818244) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHFM1ENSP000002485664STRING: ENSP00000248566
    CLP1ENSP000003047044STRING: ENSP00000304704
    GLE1ENSP000003086224STRING: ENSP00000308622
    KPNB1ENSP000002901584STRING: ENSP00000290158
    NCBP1ENSP000003642894STRING: ENSP00000364289
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0046426negative regulation of JAK-STAT cascade IEA--
    GO:0050776regulation of immune response IEA--
    GO:0051225spindle assembly IEA--
    GO:0051298centrosome duplication IEA--

    SAC3D1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAC3D1 (SAC31)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SAC3D1 gene: 
    NM_013299.3  

    Unigene Cluster for SAC3D1:

    SAC3 domain containing 1
    Hs.23642  [show with all ESTs]
    Unigene Representative Sequence: NM_013299
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531072 ENST00000533017 ENST00000528109 ENST00000530213 ENST00000529996
    ENST00000398846(uc001ocm.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SAC3D1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SAC3D1:
    hsa-miR-330-5p hsa-miR-326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SAC3D1
    Predesigned siRNA for gene silencing in human, mouse, rat SAC3D1
    Clone
    Products:
         
    OriGene clones in human, mouse for SAC3D1 (see all 6)
    OriGene ORF clones in mouse, rat for SAC3D1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAC3D1 (NM_013299)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAC3D1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SAC3D1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SAC3D1
    OriGene qSTAR qPCR primer pairs in human, mouse for SAC3D1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAC3D1
      QuantiTect SYBR Green Assays in human, mouse, rat SAC3D1
      QuantiFast Probe-based Assays in human, mouse, rat SAC3D1

    Additional mRNA sequence: 

    BC007448.2 U79266.1 

    9 DOTS entries:

    DT.95168184  DT.100789170  DT.95168186  DT.100789169  DT.91748226  DT.95080419  DT.95168183  DT.100840053 
    DT.40109964 

    Selected AceView cDNA sequences (see all 108):

    BI088075 CR607647 AI700717 AU104850 CR610152 CA429948 CR614123 CB242249 
    AI084143 BM479621 AU104849 BU631102 AA293826 CR610135 BU632849 AI498233 
    NM_013299 AI865561 BQ689122 BX463280 BM453718 R24387 CD251518 CB215128 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SAC3D1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:        -     -     -     -     -                                 
    SP2:                                -                                 
    SP3:        -                                                         
    SP4:                                -     -                           
    SP5:                                      -                           


    ECgene alternative splicing isoforms for SAC3D1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SAC3D1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCCAGGT
    SAC3D1 Expression
    About this image

    SAC3D1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAC3D1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23642
        Custom PCR Arrays for SAC3D1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SAC3D1
    OriGene qSTAR qPCR primer pairs in human, mouse for SAC3D1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAC3D1
    QuantiTect SYBR Green Assays in human, mouse, rat SAC3D1
    QuantiFast Probe-based Assays in human, mouse, rat SAC3D1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAC3D1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SAC3D1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sac3d11 , 5 SAC3 domain containing 11, 5 78.59(n)1
    78.03(a)1
      19 (4.34 cM)5
    664061  NM_133678.31  NP_598439.31 
     61160045 
    lizard
    (Anolis carolinensis)
    Reptilia SAC3D16
    SAC3 domain containing 1
    48(a)
    1 ↔ 1
    GL344077.1(81908-83806)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004892681 SAC3 domain-containing protein 1-like 51.14(n)
    42.39(a)
      100489268  XM_002937503.2  XP_002937549.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:zfos-452g4.11 si:zfos-452g4.1 51.21(n)
    43.09(a)
      561420  XM_002666432.2  XP_002666478.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG34376
    --
    24(a)
    1 ↔ 1
    3L(9449442-9450769)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1156
    Protein TAG-115 (tag-115) mRNA, complete cds
    25(a)
    1 ↔ 1
    IV(13237272-13239416) WBGene00006466
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAC36
    Nuclear pore-associated protein; required for biog...
    6(a)
    1 → many
    IV(771877-775782) YDR159W


    ENSEMBL Gene Tree for SAC3D1 (if available)
    TreeFam Gene Tree for SAC3D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SAC3D1 gene
    MCM3AP2  

    SAC3D1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SAC3D1 (see all 67)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101608111,2,,4
    C,H--64808647(+) CCCAGC/ACAGGT 1 -- ut51 ese38Minor allele frequency- A:0.11NA WA 250
    rs349985021,2
    C--64808682(+) CCCCA-/CCCCCC 1 -- ut511Minor allele frequency- C:0.00NA 2
    rs37413901,2,,4
    C,F--64809044(-) GGCGCA/GGGCGA 2 R C mis1 ese38Minor allele frequency- G:0.27EA NA WA 1854
    rs1128934961,2
    C,F--64809061(+) GCCAGC/TTTCGT 2 S syn11Minor allele frequency- T:0.19WA 118
    rs122711341,2,,4
    C--64809090(+) TGTGCG/TCCTGG 2 R L mis1 ese38Minor allele frequency- T:0.01NA CSA WA EA 367
    rs107924551,2
    C--64809133(+) GCAGCG/TGTGGT 2 A syn1 ese37Minor allele frequency- T:0.10NA WA EA 366
    rs107924561,2
    C--64809167(+) TGCTGG/ACCGTA 2 /T /A mis1 ese34Minor allele frequency- A:0.03NA EA 126
    rs1468671321,2
    --64809430(+) AACATC/GTCACC 1 -- int10--------
    rs38623741,2
    C,F,A,H--64809441(-) AGGGGG/ACTAAT 1 -- int117Minor allele frequency- A:0.35MN NS EA NA WA 2522
    rs1821218371,2
    --64809448(+) CCCTCC/GCAGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SAC3D1 (64808373 - 64812300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SAC3D1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SAC3D1
    DNA2.0 Custom Variant and Variant Library Synthesis for SAC3D1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for SAC3D1:    About MalaCards
    pertussis    malaria


    SAC3D1 for disorders           About GeneDecksing


    Export disorders for SAC3D1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SAC3D1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SAC3D1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2 Baillat D....Shiekhattar R. (Cell 2005)
    3. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    4. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. (PubMed id 15322101)1, 9 Khuda S.E....Sakaguchi N. (J. Biol. Chem. 2004)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription. (PubMed id 18838617)1 Nakajima H....Handa M. (Blood 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29901 HGNC: 30179 AceView: HSU79266 Ensembl:ENSG00000168061 euGenes: HUgn29901
    ECgene: SAC3D1 H-InvDB: SAC3D1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SAC3D1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SAC3D1 gene:
    Search GeneIP for patents involving SAC3D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SAC3D1  
     OriGene qPCR primer pairs and template standards for SAC3D1   OriGene Protein Over-expression Lysate for SAC3D1  
     OriGene MassSpec something-or-other for SAC3D1   OriGene clones in human, mouse for SAC3D1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SAC3D1   OriGene Purified Protein for SAC3D1  
     OriGene ORF clones in mouse, rat for SAC3D1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SAC3D1   OriGene Custom Protein Services for SAC3D1  

     
     
     Block miRNA regulation of human, mouse, rat SAC3D1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SAC3D1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAC3D1 Predesigned siRNA for gene silencing in human, mouse, rat SAC3D1
     QuantiFast Probe-based Assays in human, mouse, rat SAC3D1 QuantiTect SYBR Green Assays in human, mouse, rat SAC3D1
     Custom PCR Arrays for SAC3D1 Search Chromatin IP Primers for SAC3D1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAC3D1  Search GeneGlobe Interaction Network for SAC3D1
     Regulatory tfbs in SAC3D1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SAC3D1 GenScript cDNA clones with any tag delivered in your preferred vector for SAC3D1
     GenScript Custom Assay Services for SAC3D1 GenScript Custom overexpressing Cell Line Services for SAC3D1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SAC3D1 (SAC31)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SAC3D1 antibodies
     SAC3D1 proteins
     SAC3D1 lysates
     Antibodies for SAC3D1
     See all of Abcam's Antibodies, Kits and Proteins for SAC3D1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SAC3D1
     Antibodies for SAC3D1
     ELISAs for SAC3D1
     CLIAs for SAC3D1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SAC3D1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAC3D1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SAC3D1
     SwitchGear Promoter luciferase reporter plasmids for SAC3D1
     Search ThermoFisher Antibodies for SAC3D1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SAC3D1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAC3D1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SAC3D1
     Search LSBio for Antibodies for SAC3D1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SAC3D1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4