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Aliases for SAC3D1 Gene

Aliases for SAC3D1 Gene

  • SAC3 Domain Containing 1 2 3 5
  • SAC3 Homology Domain-Containing Protein 1 3 4
  • SHD1 3 4
  • SAC3 Domain-Containing Protein 1 3
  • Sac3 Homology Domain 1 3
  • HSU79266 3

External Ids for SAC3D1 Gene

Previous GeneCards Identifiers for SAC3D1 Gene

  • GC11P064566
  • GC11P064808
  • GC11P061135

Summaries for SAC3D1 Gene

GeneCards Summary for SAC3D1 Gene

SAC3D1 (SAC3 Domain Containing 1) is a Protein Coding gene. Diseases associated with SAC3D1 include Colonic Benign Neoplasm. An important paralog of this gene is MCM3AP.

UniProtKB/Swiss-Prot for SAC3D1 Gene

  • Involved in centrosome duplication and mitotic progression.

Gene Wiki entry for SAC3D1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAC3D1 Gene

Genomics for SAC3D1 Gene

Regulatory Elements for SAC3D1 Gene

Enhancers for SAC3D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065040 1.1 ENCODE 12.6 +0.2 223 2.0 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 DEK SNX15 DPF2 KAT5 RNASEH2C SAC3D1 MUS81 ZFPL1 EEF1A1P18 NAALADL1 MEN1
GH11G065109 1.4 ENCODE dbSUPER 9.3 +71.3 71319 4.8 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 EIF1AD ZFPL1 PCNX3 POLA2 ENSG00000257086 KAT5 ATG2A MRPL49 TRMT112 VPS51
GH11G065115 1.4 ENCODE dbSUPER 9.3 +76.5 76463 3.5 MLX AGO1 DMAP1 YY1 ZNF143 SP3 TBX21 ZFP41 MEF2D ZNF610 SAC3D1 SYVN1 LOC728975 SNX15 SLC22A20 ZNHIT2 ENSG00000255173
GH11G065101 1.2 ENCODE dbSUPER 9.3 +61.5 61506 1.1 ATF1 PKNOX1 CREB3L1 SIN3A FEZF1 YY1 ZNF121 GATA2 FOS REST SYVN1 FAU PGAM1P8 CAPN1 LOC728975 SPDYC SAC3D1 ENSG00000254501 TMEM262
GH11G065026 1.1 ENCODE 10.1 -13.2 -13171 2.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SNX15 SAC3D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAC3D1 on UCSC Golden Path with GeneCards custom track

Promoters for SAC3D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040767 499 1601 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13

Genomic Location for SAC3D1 Gene

Chromosome:
11
Start:
65,040,901 bp from pter
End:
65,044,828 bp from pter
Size:
3,928 bases
Orientation:
Plus strand

Genomic View for SAC3D1 Gene

Genes around SAC3D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAC3D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAC3D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAC3D1 Gene

Proteins for SAC3D1 Gene

  • Protein details for SAC3D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKF1-SAC31_HUMAN
    Recommended name:
    SAC3 domain-containing protein 1
    Protein Accession:
    A6NKF1
    Secondary Accessions:
    • A8MX08
    • Q99773

    Protein attributes for SAC3D1 Gene

    Size:
    404 amino acids
    Molecular mass:
    43553 Da
    Quaternary structure:
    • May be part of a SEM1-containing complex.
    SequenceCaution:
    • Sequence=AP003068; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAC3D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAC3D1 Gene

Post-translational modifications for SAC3D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAC3D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAC3D1 Gene

Domains & Families for SAC3D1 Gene

Protein Domains for SAC3D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAC3D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKF1

UniProtKB/Swiss-Prot:

SAC31_HUMAN :
  • Belongs to the SAC3 family.
Family:
  • Belongs to the SAC3 family.
genes like me logo Genes that share domains with SAC3D1: view

No data available for Gene Families for SAC3D1 Gene

Function for SAC3D1 Gene

Molecular function for SAC3D1 Gene

UniProtKB/Swiss-Prot Function:
Involved in centrosome duplication and mitotic progression.

Gene Ontology (GO) - Molecular Function for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with SAC3D1: view
genes like me logo Genes that share phenotypes with SAC3D1: view

Animal Models for SAC3D1 Gene

MGI Knock Outs for SAC3D1:

Animal Model Products

CRISPR Products

miRNA for SAC3D1 Gene

miRTarBase miRNAs that target SAC3D1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SAC3D1 Gene

Localization for SAC3D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAC3D1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes on centrosomes in interphase cells and at spindles in mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAC3D1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with SAC3D1: view

Pathways & Interactions for SAC3D1 Gene

SuperPathways for SAC3D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SAC3D1: view

No data available for Pathways by source and SIGNOR curated interactions for SAC3D1 Gene

Transcripts for SAC3D1 Gene

Unigene Clusters for SAC3D1 Gene

SAC3 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAC3D1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SAC3D1 Gene

GeneLoc Exon Structure for
SAC3D1
ECgene alternative splicing isoforms for
SAC3D1

Expression for SAC3D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAC3D1 Gene

mRNA differential expression in normal tissues according to GTEx for SAC3D1 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for SAC3D1 Gene

This gene is overexpressed in Breast (55.0) and Bone (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAC3D1 Gene



Protein tissue co-expression partners for SAC3D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAC3D1 Gene:

SAC3D1

SOURCE GeneReport for Unigene cluster for SAC3D1 Gene:

Hs.23642

Evidence on tissue expression from TISSUES for SAC3D1 Gene

  • Nervous system(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with SAC3D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAC3D1 Gene

Orthologs for SAC3D1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SAC3D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAC3D1 34 35
  • 98.42 (n)
dog
(Canis familiaris)
Mammalia SAC3D1 34 35
  • 84.64 (n)
cow
(Bos Taurus)
Mammalia SAC3D1 34 35
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Sac3d1 34 16 35
  • 78.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 10 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 5 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SAC3D1 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489268 34
  • 51.14 (n)
zebrafish
(Danio rerio)
Actinopterygii si:zfos-452g4.1 34
  • 51.21 (n)
SAC3D1 35
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3437 35
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-115 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC3 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToOne
Species where no ortholog for SAC3D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAC3D1 Gene

ENSEMBL:
Gene Tree for SAC3D1 (if available)
TreeFam:
Gene Tree for SAC3D1 (if available)

Paralogs for SAC3D1 Gene

Paralogs for SAC3D1 Gene

genes like me logo Genes that share paralogs with SAC3D1: view

Variants for SAC3D1 Gene

Sequence variations from dbSNP and Humsavar for SAC3D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000145233 -- 65,040,295(+) ACTAC(A/G)CCCGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000788110 -- 65,041,586(+) GTGGC(C/T)AGCTT reference, synonymous-codon
rs1001143077 -- 65,038,910(+) CAAAT(A/C)ACGGA intron-variant, upstream-variant-2KB
rs1001296983 -- 65,039,539(+) TCTTA(C/G/T)TTGTA intron-variant, upstream-variant-2KB
rs1001328180 -- 65,038,981(+) TTTTT(C/T)TGTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SAC3D1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for SAC3D1 Gene

Gene Damage Index Score: 10.20; 90.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAC3D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAC3D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAC3D1 Gene

Disorders for SAC3D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAC3D1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SAC3D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAC3D1
genes like me logo Genes that share disorders with SAC3D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAC3D1 Gene

Publications for SAC3D1 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 4 64
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 3 4 64
  3. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. (PMID: 15322101) Khuda S.E. … Sakaguchi N. (J. Biol. Chem. 2004) 3 22 64
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for SAC3D1 Gene

Sources for SAC3D1 Gene

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