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Aliases for SAC3D1 Gene

Aliases for SAC3D1 Gene

  • SAC3 Domain Containing 1 2 3 5
  • SAC3 Homology Domain-Containing Protein 1 3 4
  • SHD1 3 4
  • SAC3 Domain-Containing Protein 1 3
  • Sac3 Homology Domain 1 3
  • HSU79266 3

External Ids for SAC3D1 Gene

Previous GeneCards Identifiers for SAC3D1 Gene

  • GC11P064566
  • GC11P064808
  • GC11P061135

Summaries for SAC3D1 Gene

GeneCards Summary for SAC3D1 Gene

SAC3D1 (SAC3 Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MCM3AP.

UniProtKB/Swiss-Prot for SAC3D1 Gene

  • Involved in centrosome duplication and mitotic progression.

Gene Wiki entry for SAC3D1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAC3D1 Gene

Genomics for SAC3D1 Gene

Regulatory Elements for SAC3D1 Gene

Enhancers for SAC3D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065115 1.2 ENCODE 19.8 +76.5 76463 3.5 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC105369342 SAC3D1 RPS16P6 ENSG00000231492 CTSW NEAT1 FAU MRPL49 SYVN1 LOC728975
GH11F065040 0.4 ENCODE 12.6 +0.2 223 2.0 HDGF ATF1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SNX15 SAC3D1 NAALADL1 MEN1 PIR58637
GH11F065718 0.2 ENCODE 12.3 +678.9 678925 3.2 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MRPL11 RNASEH2C LOC105369352 LOC105369351 RPS16P6 LOC105369353 CD248 RBM4B SAC3D1 SSSCA1
GH11F065414 1.4 FANTOM5 ENCODE 12.3 +383.3 383281 18.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEAT1 ZFPL1 KAT5 EIF1AD LOC105369352 POLA2 MUS81 PCNX3 FRMD8 ENSG00000255320
GH11F064447 1 FANTOM5 ENCODE 12.3 -592.1 -592120 2.1 ATF1 CBX3 PKNOX1 ZNF48 RAD21 GLIS2 SCRT2 ZNF143 RCOR1 ETV6 LOC105369342 ENSG00000231492 RPS16P6 ENSG00000203520 SAC3D1 NRXN2 SLC22A12 FERMT3 TRMT112 EHD1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SAC3D1 on UCSC Golden Path with GeneCards custom track

Promoters for SAC3D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SAC3D1 Gene

65,040,901 bp from pter
65,044,828 bp from pter
3,928 bases
Plus strand

Genomic View for SAC3D1 Gene

Genes around SAC3D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAC3D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAC3D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAC3D1 Gene

Proteins for SAC3D1 Gene

  • Protein details for SAC3D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SAC3 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8MX08
    • Q99773

    Protein attributes for SAC3D1 Gene

    404 amino acids
    Molecular mass:
    43553 Da
    Quaternary structure:
    • May be part of a SHFM1-containing complex.
    • Sequence=AP003068; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAC3D1 Gene


neXtProt entry for SAC3D1 Gene

Post-translational modifications for SAC3D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAC3D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAC3D1 Gene

Domains & Families for SAC3D1 Gene

Protein Domains for SAC3D1 Gene


Suggested Antigen Peptide Sequences for SAC3D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAC3 family.
  • Belongs to the SAC3 family.
genes like me logo Genes that share domains with SAC3D1: view

No data available for Gene Families for SAC3D1 Gene

Function for SAC3D1 Gene

Molecular function for SAC3D1 Gene

UniProtKB/Swiss-Prot Function:
Involved in centrosome duplication and mitotic progression.

Gene Ontology (GO) - Molecular Function for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with SAC3D1: view
genes like me logo Genes that share phenotypes with SAC3D1: view

Animal Models for SAC3D1 Gene

MGI Knock Outs for SAC3D1:

Animal Model Products

miRNA for SAC3D1 Gene

miRTarBase miRNAs that target SAC3D1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SAC3D1 Gene

Localization for SAC3D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAC3D1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes on centrosomes in interphase cells and at spindles in mitosis. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SAC3D1 Gene COMPARTMENTS Subcellular localization image for SAC3D1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with SAC3D1: view

Pathways & Interactions for SAC3D1 Gene

SuperPathways for SAC3D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SAC3D1: view

No data available for Pathways by source and SIGNOR curated interactions for SAC3D1 Gene

Transcripts for SAC3D1 Gene

Unigene Clusters for SAC3D1 Gene

SAC3 domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAC3D1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SAC3D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAC3D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAC3D1 Gene

mRNA differential expression in normal tissues according to GTEx for SAC3D1 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for SAC3D1 Gene

This gene is overexpressed in Breast (55.0) and Bone (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAC3D1 Gene

Protein tissue co-expression partners for SAC3D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAC3D1 Gene:


SOURCE GeneReport for Unigene cluster for SAC3D1 Gene:

genes like me logo Genes that share expression patterns with SAC3D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SAC3D1 Gene

Orthologs for SAC3D1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SAC3D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAC3D1 34 35
  • 98.42 (n)
(Canis familiaris)
Mammalia SAC3D1 34 35
  • 84.64 (n)
(Bos Taurus)
Mammalia SAC3D1 34 35
  • 83.33 (n)
(Mus musculus)
Mammalia Sac3d1 34 16 35
  • 78.59 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 10 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 5 (a)
(Anolis carolinensis)
Reptilia SAC3D1 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489268 34
  • 51.14 (n)
(Danio rerio)
Actinopterygii si:zfos-452g4.1 34
  • 51.21 (n)
SAC3D1 35
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3437 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tag-115 35
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC3 35
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
Species where no ortholog for SAC3D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAC3D1 Gene

Gene Tree for SAC3D1 (if available)
Gene Tree for SAC3D1 (if available)

Paralogs for SAC3D1 Gene

Paralogs for SAC3D1 Gene

genes like me logo Genes that share paralogs with SAC3D1: view

Variants for SAC3D1 Gene

Sequence variations from dbSNP and Humsavar for SAC3D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10160463 -- 65,039,485(+) ccaaa(A/G)tgctg intron-variant, upstream-variant-2KB
rs10160811 -- 65,041,175(+) CCCAG(A/C)CAGGT utr-variant-5-prime
rs10792455 -- 65,041,661(+) GCAGC(G/T)GTGGT reference, synonymous-codon
rs10792456 -- 65,041,695(+) TGCTG(A/G)CCGTA reference, missense
rs112087782 -- 65,039,207(+) TTATT(A/T)TTTAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SAC3D1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for SAC3D1 Gene

Gene Damage Index Score: 10.20; 90.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAC3D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAC3D1 Gene

Disorders for SAC3D1 Gene

Relevant External Links for SAC3D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SAC3D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAC3D1 Gene

Publications for SAC3D1 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 4 64
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 3 4 64
  3. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. (PMID: 15322101) Khuda S.E. … Sakaguchi N. (J. Biol. Chem. 2004) 3 22 64
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for SAC3D1 Gene

Sources for SAC3D1 Gene

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