SAC3D1 Gene
protein-coding GIFtS: 44
GCID: GC11P064808
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SAC3 domain containing 1
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Aliases
for SAC3D1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SAC3 Domain Containing 11 2 | | SHD11 2 3 | | HSU792661 2 | | SAC3 Homology Domain-Containing Protein 12 3 | | SAC3 Domain-Containing Protein 12 | | Sac3 Homology Domain 12 |
Export aliases for SAC3D1 gene to outside databasesPrevious GC identifers: GC11P064566 GC11P061135 |
Summaries
for SAC3D1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1Function: Involved in centrosome duplication and mitotic progression (By similarity)
Gene Wiki entry for SAC3D1
|
Genomic Views
for SAC3D1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SAC3D1 gene promoter:
Brachyury SREBP-1c Meis-1b Evi-1 SREBP-1b PPAR-gamma1 SREBP-1a PPAR-gamma2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SAC3D1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAC3D1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1SAC3D1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P064808: view genomic region
(about GC identifiers)
Start:
|
64,808,373 bp from pter |
End:
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64,812,300 bp from pter |
Size:
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3,928 bases |
Orientation:
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plus strand |
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Proteins
for SAC3D1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1 (See
protein sequence)Recommended Name: SAC3 domain-containing protein 1 Size: 404 amino acids; 43553 Da
Subunit: May be part of a SHFM1-containing complex
Subcellular location: Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (Bysimilarity). Note=Localizes on centrosomes in interphase cells and at spindles in mitosis (By similarity)
Caution: It is uncertain whether Met-1 or Met-47 is the initiator
Sequence caution: Sequence=AP003068; Type=Erroneous gene model prediction;
Secondary accessions: A8MX08 Q99773Alternative splicing: 2 isoforms: A6NKF1-1 A6NKF1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SAC3D1: NX_A6NKF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NKF1
SAC3D1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037431.3
ENSEMBL proteins: ENSP00000436649 ENSP00000436704 ENSP00000381824
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SAC3D1 for ontologies About GeneDecksing
SAC3D1 Antibody Products:
Assay Products for SAC3D1: |
Protein
Domains /
Families
for SAC3D1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SAC3D1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NKF1ProtoNet protein and cluster: A6NKF1 UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1Similarity: Belongs to the SAC3 family |
Function
for SAC3D1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SAC31_HUMAN, A6NKF1Function: Involved in centrosome duplication and mitotic progression (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAC3D1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAC3D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAC3D1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SAC3D1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SAC3D1:
Animal Models:
Mouse knock-out Sac3d1tm1Hnaka for SAC3D1
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sac3d1):
SAC3D1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SAC3D1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAC3D1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SAC3D1 (ENSP000003818244) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SAC3D1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SAC3D1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SAC3D1
Search CenterWatch for drugs/clinical trials and news about SAC3D1 / SAC31
|
Transcripts
for SAC3D1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SAC3D1 gene: NM_013299.3 Unigene Cluster for SAC3D1: SAC3 domain containing 1 Hs.23642 [show with all ESTs]Unigene Representative Sequence: NM_0132996 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531072 ENST00000533017 ENST00000528109 ENST00000530213 ENST00000529996
ENST00000398846(uc001ocm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAC3D1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAC3D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SAC3D1 (NM_013299) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAC3D1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SAC3D1 |
Additional cDNA sequence: BC007448.2 U79266.1 9 DOTS entries: DT.95168184 DT.100789170 DT.95168186 DT.100789169 DT.91748226 DT.95080419 DT.95168183 DT.100840053 DT.40109964 24/108 AceView cDNA sequences (see all 108): CR610152 CR614123 BU632849 BI088075 AU104849 CR610135 BU631102 AU104850 CR607647 CA429948 AA293826 CB242249 AI700717 AI084143 BM479621 BQ689122 BX463280 CD251271 BI906496 CB215128 BF685737 AI498233 R24387 AA535964
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SAC3D1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|
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| SP1: | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for SAC3D1
|
Expression
for SAC3D1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SAC3D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTCCAGGT
About this image
See SAC3D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAC3D1
SOURCE GeneReport for Unigene cluster: Hs.23642
SABiosciences Custom PCR Arrays for SAC3D1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SAC3D1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAC3D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAC3D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAC3D1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAC3D1 |
Orthologs
for SAC3D1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SAC3D1 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for SAC3D1 (if available)
TreeFam Gene Tree for SAC3D1 (if available) |
Paralogs
for SAC3D1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SAC3D1 gene
- MCM3AP2
SAC3D1 for paralogs About GeneDecksing
|
Genomic Variants
for SAC3D1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SAC3D1 (64808373 - 64812300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SAC3D1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SAC3D1 |
|
Disorders
/ Diseases
for SAC3D1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SAC3D1 for disorders About GeneDecksing
1  disease for SAC3D1: About MalaCardspertussis
Export disorders for SAC3D1 gene to outside databases
|
Publications
for SAC3D1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SAC3D1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SAC3D1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2, 3 Yu W.... Gibbs R.A. (1997)
- Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2 Baillat D....Shiekhattar R. (2005)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. (PubMed id 15322101)1, 9 Khuda S.E....Sakaguchi N. (2004)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription. (PubMed id 18838617)1 Nakajima H....Handa M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
|
External Searches for SAC3D1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SAC3D1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SAC3D1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAC3D1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SAC3D1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SAC3D1 gene:
Search GeneIP for patents involving SAC3D1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SAC3D1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SAC3D1 | | OriGene Custom Protein Services for SAC3D1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAC3D1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SAC3D1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAC3D1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAC3D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAC3D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAC3D1 |
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| | | | Search Tocris compounds for SAC3D1 |
| |  |  |  |  | | | | |
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 | | | SAC3D1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAC3D1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SAC3D1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SAC3D1 |
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