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Aliases for SAAL1 Gene

Aliases for SAAL1 Gene

  • Serum Amyloid A Like 1 2 3 5
  • Synoviocyte Proliferation-Associated In Collagen-Induced Arthritis 1 3
  • Protein SAAL1 3
  • SPACIA1 3

External Ids for SAAL1 Gene

Previous GeneCards Identifiers for SAAL1 Gene

  • GC11M018059
  • GC11M017784

Summaries for SAAL1 Gene

GeneCards Summary for SAAL1 Gene

SAAL1 (Serum Amyloid A Like 1) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAAL1 Gene

Genomics for SAAL1 Gene

Regulatory Elements for SAAL1 Gene

Enhancers for SAAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SAAL1 on UCSC Golden Path with GeneCards custom track

Promoters for SAAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SAAL1 Gene

18,069,935 bp from pter
18,106,091 bp from pter
36,157 bases
Minus strand

Genomic View for SAAL1 Gene

Genes around SAAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAAL1 Gene

Proteins for SAAL1 Gene

  • Protein details for SAAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SAAL1
    Protein Accession:
    Secondary Accessions:
    • A6NH05

    Protein attributes for SAAL1 Gene

    474 amino acids
    Molecular mass:
    53558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAAL1 Gene

Post-translational modifications for SAAL1 Gene

  • Ubiquitination at Lys 209 and Lys 254
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SAAL1 Gene

Domains & Families for SAAL1 Gene

Protein Domains for SAAL1 Gene


Suggested Antigen Peptide Sequences for SAAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAAL1 family.
  • Belongs to the SAAL1 family.
genes like me logo Genes that share domains with SAAL1: view

No data available for Gene Families for SAAL1 Gene

Function for SAAL1 Gene

genes like me logo Genes that share phenotypes with SAAL1: view

Animal Model Products

CRISPR Products

miRNA for SAAL1 Gene

miRTarBase miRNAs that target SAAL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAAL1 Gene

Localization for SAAL1 Gene

Subcellular locations from

Jensen Localization Image for SAAL1 Gene COMPARTMENTS Subcellular localization image for SAAL1 gene
Compartment Confidence
extracellular 4
nucleus 4
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SAAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SAAL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SAAL1 Gene

Pathways & Interactions for SAAL1 Gene

SuperPathways for SAAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAAL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SAAL1 Gene

Drugs & Compounds for SAAL1 Gene

No Compound Related Data Available

Transcripts for SAAL1 Gene

mRNA/cDNA for SAAL1 Gene

Unigene Clusters for SAAL1 Gene

Serum amyloid A-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAAL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - - -
SP2: - - - -
SP3: - - - -

Relevant External Links for SAAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAAL1 Gene

mRNA expression in normal human tissues for SAAL1 Gene

Protein differential expression in normal tissues from HIPED for SAAL1 Gene

This gene is overexpressed in Bone (56.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAAL1 Gene

Protein tissue co-expression partners for SAAL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAAL1 Gene:


SOURCE GeneReport for Unigene cluster for SAAL1 Gene:

genes like me logo Genes that share expression patterns with SAAL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SAAL1 Gene

Orthologs for SAAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SAAL1 34
  • 90.49 (n)
  • 90.91 (a)
SAAL1 35
  • 64 (a)
(Canis familiaris)
Mammalia SAAL1 34
  • 91.49 (n)
  • 90.26 (a)
SAAL1 35
  • 90 (a)
(Mus musculus)
Mammalia Saal1 34
  • 82.28 (n)
  • 79.75 (a)
Saal1 16
Saal1 35
  • 80 (a)
(Pan troglodytes)
Mammalia SAAL1 34
  • 99.58 (n)
  • 99.37 (a)
SAAL1 35
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC691143 34
  • 82.21 (n)
  • 79.96 (a)
(Monodelphis domestica)
Mammalia SAAL1 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia SAAL1 35
  • 72 (a)
(Gallus gallus)
Aves SAAL1 34
  • 72.73 (n)
  • 70.24 (a)
SAAL1 35
  • 69 (a)
(Anolis carolinensis)
Reptilia SAAL1 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia saal1 34
  • 59.71 (n)
  • 55.87 (a)
Str.3398 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7504 34
(Danio rerio)
Actinopterygii saal1 34
  • 57.25 (n)
  • 53.08 (a)
zgc55505 34
saal1 35
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
Species where no ortholog for SAAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAAL1 Gene

Gene Tree for SAAL1 (if available)
Gene Tree for SAAL1 (if available)

Paralogs for SAAL1 Gene

(1) SIMAP similar genes for SAAL1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SAAL1: view

No data available for Paralogs for SAAL1 Gene

Variants for SAAL1 Gene

Sequence variations from dbSNP and Humsavar for SAAL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35525096 - 18,086,965(-) CCATC(A/G)TTCTT reference, missense
rs28930681 - 18,081,467(+) TTTGC(C/T)CAACT reference, missense
rs7942794 -- 18,084,522(+) AAAGA(C/T)ACCAG intron-variant
rs9734306 -- 18,101,193(+) aatgg(G/T)aaaaa intron-variant
rs1980096 -- 18,097,773(-) AACCT(C/T)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAAL1 Gene

Variant ID Type Subtype PubMed ID
dgv1672n54 CNV loss 21841781
esv3625486 CNV gain 21293372
nsv553606 CNV loss 21841781

Variation tolerance for SAAL1 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAAL1 Gene

Disorders for SAAL1 Gene

Relevant External Links for SAAL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SAAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAAL1 Gene

Publications for SAAL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  4. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. (PMID: 23181366) Buanne P. … Zambrano N. (J. Proteome Res. 2013) 3 65
  5. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PMID: 23956138) Foerster S. … Ritter C.A. (Proteomics 2013) 3 65

Products for SAAL1 Gene

Sources for SAAL1 Gene

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