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SAAL1 Gene

protein-coding GIFtS: 44

GC11M018059

serum amyloid A-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ41463 ^¹, ²

Descriptions
serum amyloid A-like 1 ^²

External Ids
HGNC: 25158¹
Entrez Gene: 113174²
UniProtKB: Q96ER3³
Ensembl: ENSG00000166788⁷

Search outside databases for aliases for SAAL1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAAL1 gene

Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1

SAAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M018059: (about GC identifiers)

Start:	18,058,466 bp from pter
End:	18,084,214 bp from pter
Size:	25,749 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAAL1_HUMAN, Q96ER3 (See protein sequence)

Recommended Name: Protein SAAL1

Size: 474 amino acids; 53558 Da

Secondary accessions: A6NH05

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_612430.2

ENSEMBL proteins:

ENSP00000300013

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for SAAL1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for SAAL1

Assays for SAAL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96ER3

ProtoNet protein and cluster: Q96ER3

UniProtKB/Swiss-Prot: SAAL1_HUMAN, Q96ER3

Similarity: Belongs to the SAAL1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAAL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138421

Applied Biosystems Silencer® siRNAs for SAAL1

Sigma-Aldrich siRNA for SAAL1

Sigma-Aldrich shRNA for SAAL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SAAL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_138421
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138421
untagged cDNA clone in CMV expression vector: NM_138421

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_138421

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for SAAL1 (Q96ER3²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
MARK3 P27448² MINT-63625
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAAL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAAL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138421

Sigma-Aldrich siRNA for SAAL1

Sigma-Aldrich shRNA for SAAL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_138421

REFSEQ mRNAs for SAAL1 gene:

NM_138421.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_138421

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138421
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138421
                                 untagged cDNA clone in CMV expression vector: NM_138421

Additional cDNA sequence:

AK123457.1 BC012010.1 CR590267.1 CR597687.1 CR601933.1 CR603614.1 CR616217.1 CR623466.1

CR624243.1

10 DOTS entries:

DT.111653 DT.100030113 DT.75130308 DT.95075371 DT.95075361 DT.100660651 DT.100712941 DT.100848319

DT.75101786 DT.95075372

24/170 AceView cDNA sequences (see all 170 ):

BU500203 BQ679057 BQ710337 AW403967 BU174519 AA934887 AA360962 BM772190

BQ690608 CR590267 BQ683432 AA333954 CR597687 BU184596 BU782881 BQ681098

BG759763 CR601933 CR624243 BE795910 AI682294 AA748791 BM716609 BM825094

highest scoring ESTs for SAAL1:

AA206655 AA333954 AA340908 AA360962 AK123457 AW247026 AW403967 BC012010 BE258969 BE272750

Unigene Cluster for SAAL1:

Serum amyloid A-like 1

Hs.591998 [show with all ESTs]

Unigene Representative Sequence: NM_138421

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SAAL1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13
SP1:							-				-				-														-
SP2:							-				-				-														-
SP3:											-				-												-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SAAL1

1 Ensembl transcript including schematic representation:

ENST00000300013

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAAL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAAL1

¹ / ² / ³

4 probe-sets matching SAAL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60498_at²^{, 3}	U95-C	1	1.00	1.00	0.86	0.96	AI815207	0.60	1.00	0.82	1
60497_s_at²^{, 3}	U95-C	1	1.00	1.00	0.88	1.05	AA206225	0.60	1.00	0.82	1
225614_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI815207	0.60	1.00	0.82	1
225614_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SAAL1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATTCTGCCA

SOURCE GeneReport for Unigene cluster: Hs.591998

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAAL1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAAL1¹	--	serum amyloid A-like 1	91.61(n) 90.49(a)	611958 XM_849678.1 XP_854771.1
chimpanzee (Pan troglodytes)	SAAL1¹	--	serum amyloid A-like 1	99.58(n) 99.37(a)	748800 XM_001172908.1 XP_001172908.1
cow (Bos taurus)	SAAL1¹	--	serum amyloid A-like 1	90.49(n) 90.91(a)	505038 XM_581261.3 XP_581261.2
mouse (Mus musculus)	Saal1^{1, 5}	7⁵	serum amyloid A-like 1^{1, 5}	82.28(n)¹ 79.75(a)¹	78935¹ XM_620495.3¹ XP_620495.1¹ AA172689⁵ AK019878⁵ (see all 20)
zebrafish (Danio rerio)	zgc55505²	--	hypothetical protein MGC55505	71.8(n)	393104 BC044415.1

About this table Species with no ortholog for SAAL1

ENSEMBL Gene Tree for SAAL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/164 NCBI SNPs in SAAL1 are shown (see all 164 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs871699^1,2	A,C,F,H,O	18084255(-)	`GTCCCA/GCCGGG`	1	--	ng3¹ tfbs³		7		EU EA WA NA	516
--	rs7129230^1,2	A,C,F,H	18085331(+)	`TTGCAT/CGTTTC`	1	--	ng3¹		7		EU EA WA NA	562
	rs7120654^1,2	A,F,H	18085777(+)	`tacaaG/Ctaccc`	1	--	ng3¹		2		EU WA	240
	rs12292912^1,2	C,F,H	18084940(+)	`TGTATC/TCGGAT`	1	--	ng3¹		7		EU EA WA NA	560
	rs28930681^1,2	C,F	18059590(+)	`TTTGCT/CCAACT`	1	G/S	mis¹		5		NA EU EA WA	498
--	rs7129345^1,2	A,C	18085401(+)	`ACTGGC/TTGGCT`	1	--	ng3¹		0	--	--	--	--
--	rs7940941^1,2	A,C	18058018(+)	`aacccC/Tgtctc`	1	--	ng5¹		0	--	--	--	--
	rs35525096^1,2	C,F	18065088(-)	`CCATCA/GTTCTT`	1	I/V	mis¹		5		NA EU EA WA	492
	rs16934941^1,2	F,H	18084497(+)	`TTATTC/TTATTC`	1	--	ng3¹		7		NA EU EA WA	562
--	rs7941074^1,2	A	18058159(+)	`gcactC/Tcagcc`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for SAAL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for SAAL1 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)⁴ Taylor T.D....Sakaki Y. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 113174	HGNC: 25158	AceView: LOC113174	Ensembl:ENSG00000166788	euGenes: HUgn113174
ECgene: SAAL1	H-InvDB: SAAL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SAAL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SAAL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAAL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAAL1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAAL1		Browse small molecules at Sigma-Aldrich
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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for SAAL1

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Search Novus for antibodies for SAAL1

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SAAL1 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for SAAL1

Summaries
for SAAL1

Genomic Location
for SAAL1

Proteins
for SAAL1

Protein Domains/
Families
for SAAL1

Gene Function
for SAAL1

Pathways & Interactions
for SAAL1

Drugs & Compounds
for SAAL1

Transcripts
for SAAL1

Expression
for SAAL1

Orthologs
for SAAL1

Paralogs
for SAAL1

SNPs/Variants
for SAAL1

Disorders & Mutations
for SAAL1

Medical News
for SAAL1

Publications
for SAAL1

Search for SAAL1

Genome Databases showing SAAL1

Other Databases showing SAAL1

Specialized Databases showing SAAL1

Licensable Technologies
for SAAL1

Services
for SAAL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAAL1 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor SAAL1

Summariesfor SAAL1

Genomic Locationfor SAAL1

Proteinsfor SAAL1

Protein Domains/Familiesfor SAAL1

Gene Functionfor SAAL1

Pathways & Interactionsfor SAAL1

Drugs & Compoundsfor SAAL1

Transcriptsfor SAAL1

Expression for SAAL1

Orthologsfor SAAL1

Paralogsfor SAAL1

SNPs/Variantsfor SAAL1

Disorders & Mutationsfor SAAL1

Medical Newsfor SAAL1

Publicationsfor SAAL1

Search for SAAL1

Genome Databases showing SAAL1

Other Databases showing SAAL1

Specialized Databases showing SAAL1

Licensable Technologiesfor SAAL1

Servicesfor SAAL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAAL1

Summaries
for SAAL1

Genomic Location
for SAAL1

Proteins
for SAAL1

Protein Domains/
Families
for SAAL1

Gene Function
for SAAL1

Pathways & Interactions
for SAAL1

Drugs & Compounds
for SAAL1

Transcripts
for SAAL1

Expression
for SAAL1

Orthologs
for SAAL1

Paralogs
for SAAL1

SNPs/Variants
for SAAL1

Disorders & Mutations
for SAAL1

Medical News
for SAAL1

Publications
for SAAL1

Licensable Technologies
for SAAL1

Services
for SAAL1