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Aliases for SAA4 Gene

Aliases for SAA4 Gene

  • Serum Amyloid A4, Constitutive 2 3 5
  • Constitutively Expressed Serum Amyloid A Protein 3 4
  • C-SAA 3 4
  • CSAA 3 4
  • Serum Amyloid A-4 Protein 3

External Ids for SAA4 Gene

Previous GeneCards Identifiers for SAA4 Gene

  • GC11M019374
  • GC11M019195
  • GC11M018292
  • GC11M018217
  • GC11M018209
  • GC11M018252
  • GC11M017935
  • GC11M018113

Summaries for SAA4 Gene

GeneCards Summary for SAA4 Gene

SAA4 (Serum Amyloid A4, Constitutive) is a Protein Coding gene. Diseases associated with SAA4 include Unicentric Castleman Disease and Amyloidosis Aa. Among its related pathways are Folate Metabolism. GO annotations related to this gene include chemoattractant activity. An important paralog of this gene is SAA2-SAA4.

UniProtKB/Swiss-Prot for SAA4 Gene

  • Major acute phase reactant. Apolipoprotein of the HDL complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAA4 Gene

Genomics for SAA4 Gene

Regulatory Elements for SAA4 Gene

Enhancers for SAA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F018259 0.7 ENCODE 11.7 -22.6 -22566 0.1 SOX13 CEBPG ZNF644 RAD21 TEAD3 YY1 HNF4G GATAD2A SOX5 HMG20B SAA4 LOC494141 ENSG00000254546 HIGD1AP5 SAAL1 ENSG00000255470 GLTPP1 HPS5 GC11M018255 ST13P5
GH11F018423 0.3 FANTOM5 10.5 -186.2 -186221 0.2 LDHA GTF2H1 HPS5 SAA4 YWHABP2 SAAL1 LDHC ENSG00000256734
GH11F018236 0.8 ENCODE 0.8 -0.4 -362 1.6 ELF3 TBP ATF1 MLX ARID4B THRB RAD21 RARA YY1 CREM LDHC TMEM86A LOC100129966 GC11M018180 SAA4
GH11F018228 0.2 ENCODE 0.4 +7.3 7317 1.2 ZNF512 SCRT2 GABPA SPI1 SERGEF SAA4 LOC494141
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SAA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SAA4 Gene

Chromosome:
11
Start:
18,231,349 bp from pter
End:
18,236,893 bp from pter
Size:
5,545 bases
Orientation:
Minus strand

Genomic View for SAA4 Gene

Genes around SAA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAA4 Gene

Proteins for SAA4 Gene

  • Protein details for SAA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35542-SAA4_HUMAN
    Recommended name:
    Serum amyloid A-4 protein
    Protein Accession:
    P35542
    Secondary Accessions:
    • Q6FHJ4

    Protein attributes for SAA4 Gene

    Size:
    130 amino acids
    Molecular mass:
    14747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAA4 Gene

Post-translational modifications for SAA4 Gene

  • Glycosylation at Asn 94
  • Modification sites at PhosphoSitePlus

Other Protein References for SAA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAA4 Gene

Domains & Families for SAA4 Gene

Protein Domains for SAA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35542

UniProtKB/Swiss-Prot:

SAA4_HUMAN :
  • Belongs to the SAA family.
Family:
  • Belongs to the SAA family.
genes like me logo Genes that share domains with SAA4: view

No data available for Gene Families for SAA4 Gene

Function for SAA4 Gene

Molecular function for SAA4 Gene

GENATLAS Biochemistry:
serum amyloid A,4,constitutively expressed
UniProtKB/Swiss-Prot Function:
Major acute phase reactant. Apolipoprotein of the HDL complex.
UniProtKB/Swiss-Prot Induction:
Constitutively expressed.

Gene Ontology (GO) - Molecular Function for SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042056 chemoattractant activity IBA --
genes like me logo Genes that share ontologies with SAA4: view

Phenotypes for SAA4 Gene

GenomeRNAi human phenotypes for SAA4:
genes like me logo Genes that share phenotypes with SAA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SAA4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAA4 Gene

Localization for SAA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAA4 Gene COMPARTMENTS Subcellular localization image for SAA4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IBA --
GO:0034364 high-density lipoprotein particle IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SAA4: view

Pathways & Interactions for SAA4 Gene

SuperPathways for SAA4 Gene

SuperPathway Contained pathways
1 Folate Metabolism
genes like me logo Genes that share pathways with SAA4: view

Pathways by source for SAA4 Gene

3 BioSystems pathways for SAA4 Gene

Interacting Proteins for SAA4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278222%0d%0a9606.ENSP00000364979%0d%0a
Selected Interacting proteins: ENSP00000278222 P35542-SAA4_HUMAN for SAA4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0050918 positive chemotaxis IEA --
GO:0060326 cell chemotaxis IBA --
genes like me logo Genes that share ontologies with SAA4: view

No data available for SIGNOR curated interactions for SAA4 Gene

Drugs & Compounds for SAA4 Gene

(7) Drugs for SAA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for SAA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SAA4: view

Transcripts for SAA4 Gene

mRNA/cDNA for SAA4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(249) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAA4 Gene

Serum amyloid A4, constitutive:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAA4 Gene

No ASD Table

Relevant External Links for SAA4 Gene

GeneLoc Exon Structure for
SAA4
ECgene alternative splicing isoforms for
SAA4

Expression for SAA4 Gene

mRNA expression in normal human tissues for SAA4 Gene

mRNA differential expression in normal tissues according to GTEx for SAA4 Gene

This gene is overexpressed in Liver (x51.0).

Protein differential expression in normal tissues from HIPED for SAA4 Gene

This gene is overexpressed in Serum (17.3), Synovial fluid (17.0), and Plasma (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAA4 Gene



Protein tissue co-expression partners for SAA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAA4 Gene:

SAA4

SOURCE GeneReport for Unigene cluster for SAA4 Gene:

Hs.1955

mRNA Expression by UniProt/SwissProt for SAA4 Gene:

P35542-SAA4_HUMAN
Tissue specificity: Expressed by the liver; secreted in plasma.
genes like me logo Genes that share expression patterns with SAA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SAA4 Gene

Orthologs for SAA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAA4 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAA4 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAA1 35
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Saa4 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii saa 35
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8158 34
Species where no ortholog for SAA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAA4 Gene

ENSEMBL:
Gene Tree for SAA4 (if available)
TreeFam:
Gene Tree for SAA4 (if available)

Paralogs for SAA4 Gene

Paralogs for SAA4 Gene

(3) SIMAP similar genes for SAA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SAA4: view

Variants for SAA4 Gene

Sequence variations from dbSNP and Humsavar for SAA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10707598 -- 18,237,428(+) GTTGC(-/T)TTTTT intron-variant, upstream-variant-2KB
rs10832908 -- 18,238,155(+) TTTTG(A/G)TTTCA intron-variant, upstream-variant-2KB
rs11024574 -- 18,236,471(+) AATTC(G/T)CAGCC intron-variant
rs111348399 -- 18,238,597(+) ATGCG(C/T)AATAA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111670913 -- 18,235,834(+) TTCTT(A/C)CCTTG splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for SAA4 Gene

Variant ID Type Subtype PubMed ID
nsv519650 CNV loss 19592680

Variation tolerance for SAA4 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAA4 Gene

Human Gene Mutation Database (HGMD)
SAA4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAA4 Gene

Disorders for SAA4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SAA4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
unicentric castleman disease
  • localized castleman disease
amyloidosis aa
  • aa amyloidosis
cryopyrin-associated periodic syndrome
  • caps
amyloidosis
  • amyloid disease
recessive dystrophic epidermolysis bullosa
  • autosomal recessive dystrophic epidermolysis bullosa generalisata gravis
- elite association - COSMIC cancer census association via MalaCards
Search SAA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SAA4

Genetic Association Database (GAD)
SAA4
Human Genome Epidemiology (HuGE) Navigator
SAA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAA4
genes like me logo Genes that share disorders with SAA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAA4 Gene

Publications for SAA4 Gene

  1. Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry. (PMID: 8783012) Ducret A. … Aebersold R. (Electrophoresis 1996) 3 4 22 64
  2. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute- phase serum amyloid A protein gene (SAA2). (PMID: 7686132) Steel D.M. … Whitehead A.S. (Genomics 1993) 3 4 22 64
  3. Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4. (PMID: 1439582) Watson G. … Woo P. (Scand. J. Immunol. 1992) 3 4 22 64
  4. Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. (PMID: 1740433) Whitehead A.S. … Debeer F.C. (J. Biol. Chem. 1992) 3 4 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for SAA4 Gene

  • Cloud-Clone Corp. Antibodies for SAA4
  • Cloud-Clone Corp. Proteins for SAA4
  • Cloud-Clone Corp Assay Kits for SAA4

Sources for SAA4 Gene

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