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Aliases for SAA4 Gene

Aliases for SAA4 Gene

  • Serum Amyloid A4, Constitutive 2 3 5
  • Constitutively Expressed Serum Amyloid A Protein 3 4
  • C-SAA 3 4
  • CSAA 3 4
  • Serum Amyloid A-4 Protein 3

External Ids for SAA4 Gene

Previous GeneCards Identifiers for SAA4 Gene

  • GC11M019374
  • GC11M019195
  • GC11M018292
  • GC11M018217
  • GC11M018209
  • GC11M018252
  • GC11M017935
  • GC11M018113

Summaries for SAA4 Gene

GeneCards Summary for SAA4 Gene

SAA4 (Serum Amyloid A4, Constitutive) is a Protein Coding gene. Diseases associated with SAA4 include Unicentric Castleman Disease and Amyloidosis Aa. Among its related pathways are Folate Metabolism. Gene Ontology (GO) annotations related to this gene include chemoattractant activity. An important paralog of this gene is SAA2-SAA4.

UniProtKB/Swiss-Prot for SAA4 Gene

  • Major acute phase reactant. Apolipoprotein of the HDL complex.

Additional gene information for SAA4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAA4 Gene

Genomics for SAA4 Gene

GeneHancer (GH) Regulatory Elements for SAA4 Gene

Promoters and enhancers for SAA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I018236 Promoter/Enhancer 1.4 EPDnew ENCODE 550.8 -0.4 -361 1.6 ELF3 FOXA2 MLX ARID4B THRB RAD21 RARA YY1 ATF7 CREM GC11M018180 SAA4 LDHC TMEM86A LOC100129966 SAA2-SAA4
GH11I018259 Enhancer 0.8 ENCODE 11.7 -22.6 -22566 0.1 SOX13 FOXA2 MAX CEBPG ZNF644 RAD21 YY1 TEAD3 LCORL HNF4G GC11M018255 SAA4 LOC494141 LOC645319 HIGD1AP5 SAAL1 ENSG00000255470 GLTPP1 HPS5 ST13P5
GH11I018261 Promoter 0.5 Ensembl 11.4 -25.1 -25108 0.4 GC11P018262 ST13P5 SAA4
GH11I018423 Enhancer 0.2 FANTOM5 10.5 -186.2 -186221 0.2 LDHA HPS5 GTF2H1 SAA4 YWHABP2 SAAL1 LDHC ENSG00000256734
GH11I018228 Enhancer 0.3 ENCODE 0.4 +7.3 7317 1.2 SPI1 SERGEF GC11M018180 SAA4 LOC494141
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAA4 gene promoter:

Genomic Locations for SAA4 Gene

Genomic Locations for SAA4 Gene
5,545 bases
Minus strand

Genomic View for SAA4 Gene

Genes around SAA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAA4 Gene

Proteins for SAA4 Gene

  • Protein details for SAA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serum amyloid A-4 protein
    Protein Accession:
    Secondary Accessions:
    • Q6FHJ4

    Protein attributes for SAA4 Gene

    130 amino acids
    Molecular mass:
    14747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAA4 Gene

Post-translational modifications for SAA4 Gene

Other Protein References for SAA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAA4 Gene

Domains & Families for SAA4 Gene

Gene Families for SAA4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SAA4 Gene


Suggested Antigen Peptide Sequences for SAA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAA family.
  • Belongs to the SAA family.
genes like me logo Genes that share domains with SAA4: view

Function for SAA4 Gene

Molecular function for SAA4 Gene

GENATLAS Biochemistry:
serum amyloid A,4,constitutively expressed
UniProtKB/Swiss-Prot Function:
Major acute phase reactant. Apolipoprotein of the HDL complex.
UniProtKB/Swiss-Prot Induction:
Constitutively expressed.

Gene Ontology (GO) - Molecular Function for SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042056 chemoattractant activity IBA --
genes like me logo Genes that share ontologies with SAA4: view

Phenotypes for SAA4 Gene

GenomeRNAi human phenotypes for SAA4:
genes like me logo Genes that share phenotypes with SAA4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAA4 Gene

Localization for SAA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAA4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAA4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IBA --
GO:0034364 high-density lipoprotein particle IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with SAA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SAA4 Gene

Pathways & Interactions for SAA4 Gene

genes like me logo Genes that share pathways with SAA4: view

Pathways by source for SAA4 Gene

Interacting Proteins for SAA4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000278222 P35542-SAA4_HUMAN for SAA4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0050918 positive chemotaxis IEA --
GO:0060326 cell chemotaxis IBA --
genes like me logo Genes that share ontologies with SAA4: view

No data available for SIGNOR curated interactions for SAA4 Gene

Drugs & Compounds for SAA4 Gene

(8) Drugs for SAA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for SAA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SAA4: view

Transcripts for SAA4 Gene

mRNA/cDNA for SAA4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(249) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAA4 Gene

Serum amyloid A4, constitutive:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAA4 Gene

No ASD Table

Relevant External Links for SAA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAA4 Gene

mRNA differential expression in normal tissues according to GTEx for SAA4 Gene

This gene is overexpressed in Liver (x51.0).

Protein differential expression in normal tissues from HIPED for SAA4 Gene

This gene is overexpressed in Serum (17.3), Synovial fluid (17.0), and Plasma (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAA4 Gene

Protein tissue co-expression partners for SAA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAA4 Gene:


SOURCE GeneReport for Unigene cluster for SAA4 Gene:


mRNA Expression by UniProt/SwissProt for SAA4 Gene:

Tissue specificity: Expressed by the liver; secreted in plasma.

Evidence on tissue expression from TISSUES for SAA4 Gene

  • Liver(4.7)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with SAA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAA4 Gene

Orthologs for SAA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAA4 34
  • 98 (a)
(Bos Taurus)
Mammalia SAA4 34
  • 65 (a)
(Canis familiaris)
Mammalia SAA1 34
  • 59 (a)
(Mus musculus)
Mammalia Saa4 34
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
-- 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
-- 34
  • 45 (a)
-- 34
  • 37 (a)
(Gallus gallus)
Aves -- 34
  • 46 (a)
(Danio rerio)
Actinopterygii saa 34
  • 46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8158 33
Species where no ortholog for SAA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAA4 Gene

Gene Tree for SAA4 (if available)
Gene Tree for SAA4 (if available)

Paralogs for SAA4 Gene

Paralogs for SAA4 Gene

(3) SIMAP similar genes for SAA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SAA4: view

Variants for SAA4 Gene

Sequence variations from dbSNP and Humsavar for SAA4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000319066 -- 18,233,677(-) AA/AAA intron_variant
rs1000414249 -- 18,236,392(-) T/C intron_variant
rs1000539185 -- 18,233,914(-) A/T intron_variant
rs1001412130 -- 18,237,942(-) C/G/T upstream_transcript_variant
rs1001728338 -- 18,231,240(-) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SAA4 Gene

Variant ID Type Subtype PubMed ID
nsv519650 CNV loss 19592680

Variation tolerance for SAA4 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAA4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAA4 Gene

Disorders for SAA4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SAA4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
unicentric castleman disease
  • localized castleman disease
amyloidosis aa
  • aa amyloidosis
cryopyrin-associated periodic syndrome
  • caps
familial mediterranean fever
  • fmf
  • amyloid disease
- elite association - COSMIC cancer census association via MalaCards
Search SAA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SAA4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SAA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAA4 Gene

Publications for SAA4 Gene

  1. Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry. (PMID: 8783012) Ducret A … Aebersold R (Electrophoresis 1996) 3 4 22 58
  2. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2). (PMID: 7686132) Steel DM … Whitehead AS (Genomics 1993) 3 4 22 58
  3. Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4. (PMID: 1439582) Watson G … Woo P (Scandinavian journal of immunology 1992) 3 4 22 58
  4. Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. (PMID: 1740433) Whitehead AS … de Beer FC (The Journal of biological chemistry 1992) 3 4 22 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SAA4 Gene

Sources for SAA4 Gene

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