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SAA4 Gene

protein-coding   GIFtS: 56

GC11M018209
serum amyloid A4, constitutive
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C-SAA 1, 2, 3
CSAA 1, 2, 3
Descriptions
Constitutively expressed serum amyloid A protein 3
serum amyloid A4, constitutive 2
External Ids
HGNC: 105161
Entrez Gene: 62912
UniProtKB: P355423
Ensembl: ENSG000001489657
Search outside databases for aliases for SAA4 gene

Previous GC identifers: GC11M019374 GC11M019195 GC11M018292 GC11M018217

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Function: Major acute phase reactant. Apolipoprotein of the HDL complex

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SAA4 gene  

Entrez Gene cytogenetic band: 11p15.1-p14   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1-p14

SAA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018209:     (about GC identifiers)

Start:
18,209,479 bp from pter
End:
18,214,910 bp from pter
Size:
5,432 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542 (See protein sequence)
Recommended Name: Serum amyloid A-4 protein precursor  
Size: 130 amino acids; 14807 Da
Subcellular location: Secreted

REFSEQ proteins: NP_006503.1  

ENSEMBL proteins: 
ENSP00000278222 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (SAA4)
Human Recombinant Proteins from Abnova (SAA4)
              OriGene Purified Recombinant Human Protein: SAA4 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region NAS14718574
GO:0034364 high-density lipoprotein particle IEA--
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Antibodies for SAA4: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for SAA4
R&D Systems Antibodies for SAA4 (Serum Amyloid A4)
Antibodies from Abcam (SAA4), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (SAA4)
Novus Biologicals Antibodies for SAA4

Assays for SAA4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR000096 Serum_amyloid_A


   GeneDecks  SAA4 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P35542

ProtoNet protein and cluster: P35542

1 Blocks protein family: IPB000096 Serum amyloid A protein

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Similarity: Belongs to the SAA family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SAA4)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SAA4)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006512

              Applied Biosystems Silencer® siRNAs for SAA4

              Sigma-Aldrich siRNA for SAA4  
                     Sigma-Aldrich shRNA for SAA4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for SAA4
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006512
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006512
                                 untagged cDNA clone in CMV expression vector: NM_006512 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006512

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Function: Major acute phase reactant. Apolipoprotein of the HDL complex
Induction: Constitutively expressed

Genatlas biochemistry entry for SAA4:
serum amyloid A,4,constitutively expressed
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SAA4  (Your Favorite Gene powered by Ingenuity) 
 Acute Phase Response Signaling

   GeneDecks  SAA4 for the pathways selected above  
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5/11 Interacting proteins for SAA4 (ENSP000002782223 P355422) via UniProtKB, MINT, and/or STRING (see all 11 )
InteractantInteraction Details
GeneCardExternal ID(s)
IL6ENSP000002587433STRING (score=.864)
FPR2ENSP000003401913STRING (score=.848)
IL22ENSP000003293843STRING (score=.803)
IL1BENSP000002633413STRING (score=.802)
IL10ENSP000003560663STRING (score=.75)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006953 acute-phase response IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAA4
10/15 Novoseek chemical compound relationships for SAA4 gene (see all 15 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen 49.04 15 1705051 (2), 7554393 (1), 17978466 (1), 18205762 (1) (see all 14)
neopterin 44.07 7 9760020 (6), 10946028 (1)
(+-)-pgf2-alpha 23.22 1 15763433 (1)
cholesterol 11.67 15 17034364 (1), 10027805 (1), 2127535 (1), 11266189 (1) (see all 9)
uric acid 11.62 3 17030466 (1), 11266189 (1), 17611050 (1)
homocysteine 10.20 2 16477056 (1), 18500463 (1)
latex 9.45 1 8434870 (1)
endotoxin 3.02 1 8091133 (1)
calcium 2.28 1 1439582 (1)
ptca 0.00 2 10551701 (1), 9832480 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SAA4)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SAA4)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006512

              Sigma-Aldrich siRNA for SAA4  
                     Sigma-Aldrich shRNA for SAA4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006512  

REFSEQ mRNAs for SAA4 gene: 

NM_006512.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006512  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006512
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006512
                                 untagged cDNA clone in CMV expression vector: NM_006512 

Additional cDNA sequence: 

AK312182.1 BC007026.1 CR541758.1 M81349.1 

3 DOTS entries:

DT.406262  DT.91749078  DT.91748266 

24/249 AceView cDNA sequences (see all 249 ):

AA343695 BU607521 AV699045 AV657148 BF126524 BX495622 BG563576 BU685219 
AV655850 BV169293 AV655767 NM_006512 M23699 BG569107 BG617803 AI084001 
BG617482 BG568159 BG565030 M23700 BX457214 BX283962 BG568021 BC020795 

highest scoring ESTs for SAA4:

M81349 T85799 AV645558 AV651528 AV655850 AV655904 AV699045 BC007026 BF126600 BG562517 

Unigene Cluster for SAA4:

Serum amyloid A4, constitutive
Hs.654493  [show with all ESTs]
Unigene Representative Sequence: BG564326


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000278222  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SAA4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SAA4

1 / 2 / 3

3 probe-sets matching SAA4 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
32369_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 M81349 0.80 0.70 0.75 1

207096_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006512 0.40 0.50 0.45 1

207096_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  SAA4 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGCAGAGCCT

SOURCE GeneReport for Unigene cluster: Hs.654493

Expression variation in blood from EXPOLDB for SAA4

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Tissue specificity: Expressed by the liver; secreted in plasma

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for SAA4 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
SAA41   -- serum amyloid A4, constitutive 99.74(n)
99.23(a)
748829  XM_001173002.1  XP_001173002.1 
cow
(Bos taurus)
SAA41   -- serum amyloid A4, constitutive 75.45(n)
65.12(a)
505308  NM_001040505.1  NP_001035595.1 
rat
(Rattus norvegicus)
Saa41   -- serum amyloid A4, constitutive 72.56(n)
59.23(a)
365245  NM_001009478.1  NP_001009478.1 
mouse
(Mus musculus)
Saa41, 5 7 (23.50 cM)5
serum amyloid A 41, 5 71.28(n)1
57.69(a)1
202111  NM_011316.31  NP_035446.11 
 BC0192125  U025545  (see all 7)
rainbow trout
(Oncorhynchus mykiss)
Omy.81582   -- S.gairdneri mRNA for acute phase serum amyloid A 74.94(n)  X99387.1 
About this table        Species with no ortholog for SAA4

ENSEMBL Gene Tree for SAA4
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for SAA4 gene
SAA3P2  SAA12  SAA22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/56 NCBI SNPs in SAA4 are shown (see all 56 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs13786091,2
A,C,F,H,O18214858(-) TTTCAG/TCTGGA 1 -- ut51 ese312Minor allele frequency- A:0.02NS NA EU EA WA 662
rs108329081,2
A,C,F,H18216278(+) TTTTGG/ATTTCA 1 -- ng318Minor allele frequency- A:0.24EU EA WA 838
rs21683631,2
A,C,F,H18215504(-) TTTAAA/GAGAAA 1 -- ng314Minor allele frequency- G:0.24EU EA WA 416
rs24608271,2
A,C,F,H18209752(+) AATAGT/CAGTCT 1 C/Y mis111Minor allele frequency- C:0.15NA EU EA WA 972
--
rs169352261,2
F18215126(+) TTTTTA/CGTTTC 1 -- ng313Minor allele frequency- C:0.01NA 142
rs110245741,2
A,C,F,H18214594(+) AATTCT/GCAGCC 1 -- int17Minor allele frequency- G:0.19EU EA WA NA 560
rs24451761,2
A,C,F,H18213097(-) GCCGGG/TGTTTG 1 -- int18Minor allele frequency- T:0.43EU EA WA 840
rs29251451,2
A,C,F,H18213699(-) GGGGTG/TATCTC 1 -- int14Minor allele frequency- T:0.41EU EA WA 420
rs29566321,2
A,C,F,H18213593(-) CAAGAT/CTGAGA 1 -- int17Minor allele frequency- C:0.13EU EA WA NA 690
rs127934941,2
C,F,H18211289(+) GAGAGC/ATTCAT 1 -- int18Minor allele frequency- A:0.15EU EA WA 840
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HapMap Linkage Disequilibrium images for SAA4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 104752

10/31 Novoseek disease relationships for SAA4 gene (see all 31 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
response acute phase 79.33 5 1995703 (1), 10191288 (1), 10361047 (1), 9040576 (1) (see all 5)
amyloidosis secondary 77.54 2 8804360 (1), 9800479 (1)
amyloidosis 77.19 15 18379834 (2), 11454373 (2), 1691798 (1), 12270922 (1) (see all 13)
amyloidosis systemic 68.64 1 17062163 (1)
inflammation 63.09 32 1958088 (2), 10361047 (2), 8137804 (1), 11166375 (1) (see all 28)
familial mediterranean fever 62.86 1 12942707 (1)
rheumatoid arthritis 50.56 7 8804360 (1), 9002005 (1), 1691798 (1), 12270922 (1) (see all 7)
renal amyloidosis 48.82 1 12751000 (1)
amyloid deposition 44.22 1 16172171 (1)
atherosclerosis 38.39 6 11809924 (1), 12270922 (1), 16477056 (1), 10418738 (1) (see all 5)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/241 PubMed articles for SAA4 gene (see all 241 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6291 HGNC: 10516 AceView: SAA4andSAA2 Ensembl:ENSG00000148965 euGenes: HUgn6291
ECgene: SAA4 H-InvDB: SAA4
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SAA4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SAA4-related products

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 Predesigned and custom siRNAs for SAA4 Antibodies for SAA4
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SAA4 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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(SAA4)
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 Tagged/untagged cDNA clones
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 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for SAA4




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for SAA4

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