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Aliases & Descriptions for SAA4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| C-SAA 1, 2, 3 | | CSAA 1, 2, 3 |
| | | Descriptions |
|---|
| Constitutively expressed serum amyloid A protein 3 | | serum amyloid A4, constitutive 2 |
|
| | Search outside databases for aliases for SAA4 genePrevious GC identifers: GC11M019374 GC11M019195 GC11M018292 GC11M018217 |
Summaries for SAA4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542Function: Major acute phase reactant. Apolipoprotein of the HDL complex |
Genomic Location for SAA4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAA4 gene 
Entrez Gene cytogenetic band: 11p15.1-p14 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1-p14SAA4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M018209:
(about GC identifiers)
Start:
|
18,209,479 bp from pter |
End:
|
18,214,910 bp from pter |
Size:
|
5,432 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_009237.17
| Proteins for SAA4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542 (See
protein sequence)Recommended Name: Serum amyloid A-4 protein precursor Size: 130 amino acids; 14807 Da
Subcellular location: SecretedREFSEQ proteins: NP_006503.1
ENSEMBL proteins: ENSP00000278222
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: SAA4 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SAA4: Assays for SAA4: | Protein
Domains/ Families for SAA4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P35542
ProtoNet protein and cluster: P35542 1 Blocks protein family: IPB000096 Serum amyloid A protein
UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542Similarity: Belongs to the SAA family | Gene Function for SAA4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006512
Applied Biosystems Silencer® siRNAs for SAA4
Sigma-Aldrich siRNA for SAA4  Sigma-Aldrich shRNA for SAA4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006512                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006512                                  untagged cDNA clone in CMV expression vector: NM_006512 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006512
UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542Function: Major acute phase reactant. Apolipoprotein of the HDL complexInduction: Constitutively expressedGenatlas biochemistry entry for SAA4:serum amyloid A,4,constitutively expressed | Pathways & Interactions for SAA4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAA4 (Your Favorite Gene powered by Ingenuity) 
5/11 Interacting proteins for SAA4 (ENSP000002782223 P355422) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006953 | acute-phase response |
IEA | -- | About this table
|
Drugs & Compounds for SAA4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAA4 10/15 Novoseek chemical compound relationships for SAA4 gene (see all 15
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fibrinogen |
49.04 |
15 |
1705051 (2), 7554393 (1), 17978466 (1), 18205762 (1) (see all 14) |
| neopterin |
44.07 |
7 |
9760020 (6), 10946028 (1) |
| (+-)-pgf2-alpha |
23.22 |
1 |
15763433 (1) |
| cholesterol |
11.67 |
15 |
17034364 (1), 10027805 (1), 2127535 (1), 11266189 (1) (see all 9) |
| uric acid |
11.62 |
3 |
17030466 (1), 11266189 (1), 17611050 (1) |
| homocysteine |
10.20 |
2 |
16477056 (1), 18500463 (1) |
| latex |
9.45 |
1 |
8434870 (1) |
| endotoxin |
3.02 |
1 |
8091133 (1) |
| calcium |
2.28 |
1 |
1439582 (1) |
| ptca |
0.00 |
2 |
10551701 (1), 9832480 (1) |
About this table
|
Transcripts for SAA4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006512
Sigma-Aldrich siRNA for SAA4  Sigma-Aldrich shRNA for SAA4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006512 REFSEQ mRNAs for SAA4 gene: NM_006512.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006512               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006512                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006512                                  untagged cDNA clone in CMV expression vector: NM_006512  Additional cDNA sequence: AK312182.1 BC007026.1 CR541758.1 M81349.1 3 DOTS entries: DT.406262 DT.91749078 DT.91748266 24/249 AceView cDNA sequences (see all 249
):AA343695 BU607521 AV699045 AV657148 BF126524 BX495622 BG563576 BU685219 AV655850 BV169293 AV655767 NM_006512 M23699 BG569107 BG617803 AI084001 BG617482 BG568159 BG565030 M23700 BX457214 BX283962 BG568021 BC020795
highest scoring ESTs for SAA4:M81349 T85799 AV645558 AV651528 AV655850 AV655904 AV699045 BC007026 BF126600 BG562517 Unigene Cluster for SAA4: Serum amyloid A4, constitutive Hs.654493 [show with all ESTs]Unigene Representative Sequence: BG564326
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000278222
|
Expression for SAA4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAA4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAA4
1 / 2 / 3 3 probe-sets matching SAA4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGCAGAGCCT
SOURCE GeneReport for Unigene cluster: Hs.654493
Expression variation in blood from EXPOLDB for SAA4 UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542Tissue specificity: Expressed by the liver; secreted in plasma |
Orthologs for SAA4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAA4 gene from 5 species
About this table Species with no ortholog for SAA4
ENSEMBL Gene Tree for SAA4 | Paralogs for SAA4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SAA4 gene
- SAA3P2 SAA12 SAA22
|
SNPs/Variants for SAA4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAA4 (up to first 250kb)
|
Disorders & Mutations for SAA4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 104752
10/31 Novoseek disease relationships for SAA4 gene (see all 31
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| response acute phase |
79.33 |
5 |
1995703 (1), 10191288 (1), 10361047 (1), 9040576 (1) (see all 5) |
| amyloidosis secondary |
77.54 |
2 |
8804360 (1), 9800479 (1) |
| amyloidosis |
77.19 |
15 |
18379834 (2), 11454373 (2), 1691798 (1), 12270922 (1) (see all 13) |
| amyloidosis systemic |
68.64 |
1 |
17062163 (1) |
| inflammation |
63.09 |
32 |
1958088 (2), 10361047 (2), 8137804 (1), 11166375 (1) (see all 28) |
| familial mediterranean fever |
62.86 |
1 |
12942707 (1) |
| rheumatoid arthritis |
50.56 |
7 |
8804360 (1), 9002005 (1), 1691798 (1), 12270922 (1) (see all 7) |
| renal amyloidosis |
48.82 |
1 |
12751000 (1) |
| amyloid deposition |
44.22 |
1 |
16172171 (1) |
| atherosclerosis |
38.39 |
6 |
11809924 (1), 12270922 (1), 16477056 (1), 10418738 (1) (see all 5) |
About this table
|
Medical News for SAA4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAA4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/241 PubMed articles for SAA4 gene (see all 241
):- Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. (PubMed id 1740433)1, 3, 4 Whitehead A.S.... Debeer F.C. (1992)
- Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4. (PubMed id 1439582)1, 3, 4 Watson G.... Woo P. (1992)
- Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry. (PubMed id 8783012)1, 3, 4 Ducret A.... Aebersold R. (1996)
- A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute- phase serum amyloid A protein gene (SAA2). (PubMed id 7686132)1, 3, 4 Steel D.M....Whitehead A.S. (1993)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Localization of four human serum amyloid A (SAA) protein superfamily genes to chromosome 11p: characterization of a fifth SAA-related gene sequence. (PubMed id 8325654)2, 3 Sellar G.C. and Whitehead A.S. (1993)
- Characterization of constitutive human serum amyloid A protein (SAA4) as an apolipoprotein. (PubMed id 7775864)1, 3 de Beer M.C....de Beer F.C. (1995)
- Silent mutations in secondary Shine-Dalgarno sequences in the cDNA of human serum amyloid A4 promotes expression of recombinant protein in Escherichia coli. (PubMed id 11809924)1, 3 Hrzenjak A....Malle E. (2001)
- The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis. (PubMed id 8188252)1, 3 Sellar G.C....Whitehead A.S. (1994)
|
Search for SAA4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAA4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAA4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAA4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAA4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SAA4:

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