Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAA4 Gene

protein-coding   GIFtS: 58
GCID: GC11M018252

Serum Amyloid A4, Constitutive

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serum Amyloid A4, Constitutive1 2
Constitutively Expressed Serum Amyloid A Protein2 3
C-SAA2 3
CSAA2 3
Serum Amyloid A-4 Protein2

External Ids:    HGNC: 105161   Entrez Gene: 62912   Ensembl: ENSG000001489657   OMIM: 1047525   UniProtKB: P355423   

Export aliases for SAA4 gene to outside databases

Previous GC identifers: GC11M019374 GC11M019195 GC11M018292 GC11M018217 GC11M018209 GC11M017935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SAA4 Gene: 
SAA4 (serum amyloid A4, constitutive) is a protein-coding gene. Diseases associated with SAA4 include amyloidosis, renal, and secondary amyloidosis. An important paralog of this gene is SAA1.

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Function: Major acute phase reactant. Apolipoprotein of the HDL complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAA4 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SAA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1-p14   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1-p14

SAA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018252:  view genomic region     (about GC identifiers)

Start:
18,252,896 bp from pter      End:
18,258,440 bp from pter
Size:
5,545 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542 (See protein sequence)
Recommended Name: Serum amyloid A-4 protein precursor  
Size: 130 amino acids; 14747 Da
Subcellular location: Secreted
Secondary accessions: Q6FHJ4

Explore the universe of human proteins at neXtProt for SAA4: NX_P35542

Explore proteomics data for SAA4 at MOPED 

SAA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SAA4 Protein Expression

REFSEQ proteins: NP_006503.2  
ENSEMBL proteins: 
 ENSP00000278222  

Human Recombinant Protein Products for SAA4: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for SAA4
OriGene Custom MassSpec 
OriGene Custom Protein Services for SAA4
GenScript Custom Purified and Recombinant Proteins Services for SAA4
Novus Biologicals SAA4 Proteins
Novus Biologicals SAA4 Lysates
Sino Biological Recombinant Protein for SAA4
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for SAA4
Cloud-Clone Corp. Proteins for SAA4 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS14718574
GO:0034364high-density lipoprotein particle IEA--

SAA4 for ontologies           About GeneDecksing



SAA4 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for SAA4 (Serum Amyloid A4)
OriGene Antibodies for SAA4
OriGene Custom Antibody Services for SAA4
GenScript Custom Superior Antibodies Services for SAA4
Novus Biologicals SAA4 Antibodies
Abcam antibodies for SAA4
Cloud-Clone Corp. Antibodies for SAA4 
ThermoFisher Antibodies for SAA4
LSBio Antibodies in human, mouse, rat for SAA4 

Assay Products for SAA4: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SAA4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SAA4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SAA4 
Cloud-Clone Corp. CLIAs for SAA4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR000096 Serum_amyloid_A

Graphical View of Domain Structure for InterPro Entry P35542

ProtoNet protein and cluster: P35542

1 Blocks protein domain: IPB000096 Serum amyloid A protein

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Similarity: Belongs to the SAA family


SAA4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SAA4_HUMAN, P35542
Function: Major acute phase reactant. Apolipoprotein of the HDL complex
Induction: Constitutively expressed

     Genatlas biochemistry entry for SAA4:
serum amyloid A,4,constitutively expressed

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for SAA4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAA4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAA4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAA4 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAA4
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SAA4
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SAA4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAA4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SAA4
Sirion Biotech Customized adenovirus for overexpression of SAA4

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for SAA4 (see all 7)
OriGene ORF clones in mouse, rat for SAA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SAA4 (NM_006512)
Sino Biological Human cDNA Clone for SAA4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAA4
Sirion Biotech Customized lentivirus for stable overexpression of SAA4 
                     Customized lentivirus expression plasmids for stable overexpression of SAA4 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SAA4
Search LifeMap BioReagents cell lines for SAA4
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAA4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SAA4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Selenium Pathway
Selenium Pathway
2Folate Metabolism
Folate Metabolism


2 BioSystems Pathways for SAA4
    Selenium Pathway
Folate Metabolism



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAA4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/9 Interacting proteins for SAA4 (P355422, 3 ENSP000002782224) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000206408O958723I2D: score=1 
ENSG00000223932O958723I2D: score=1 
ENSG00000228605O958723I2D: score=1 
ENSG00000232312O958723I2D: score=1 
ENSG00000236011O958723I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006953acute-phase response IEA--

SAA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SAA4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SAA4

10/21 Novoseek inferred chemical compound relationships for SAA4 gene (see all 21)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen 49.8 16 1705051 (2), 7554393 (1), 17978466 (1), 18205762 (1) (see all 15)
neopterin 42.5 7 9760020 (6), 10946028 (1)
prostaglandin f2alpha 37.6 8 15939073 (1), 15037525 (1), 15763433 (1), 15920054 (1) (see all 6)
8-isoprostane 35 3 15037525 (1), 15763433 (1), 16036356 (1)
(+-)-pgf2-alpha 33.6 2 15763433 (1), 19542629 (1)
creatinine 26.6 5 7880233 (2), 10828628 (1), 18991244 (1), 19915083 (1)
leflunomide 22 1 15695308 (1)
uric acid 16.2 4 17030466 (1), 11266189 (1), 19915083 (1), 17611050 (1)
alpha tocopherol 11.7 2 15939073 (1), 15037525 (1)
cholesterol 11.5 15 17034364 (1), 10027805 (1), 2127535 (1), 11266189 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about SAA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SAA4 gene: 
NM_006512.3  

Unigene Cluster for SAA4:

Serum amyloid A4, constitutive
Hs.1955  [show with all ESTs]
Unigene Representative Sequence: BG564326
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000278222(uc001mny.3)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAA4
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SAA4
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SAA4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAA4
Clone
Products:
     
OriGene clones in human, mouse for SAA4 (see all 7)
OriGene ORF clones in mouse, rat for SAA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SAA4 (NM_006512)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAA4
Sirion Biotech Customized lentivirus for stable overexpression of SAA4 
                     Customized lentivirus expression plasmids for stable overexpression of SAA4 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SAA4
OriGene qSTAR qPCR primer pairs in human, mouse for SAA4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAA4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAA4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAA4

Additional mRNA sequence: 

AK312182.1 BC007026.1 CR541758.1 M81349.1 

3 DOTS entries:

DT.406262  DT.91749078  DT.91748266 

24/249 AceView cDNA sequences (see all 249):

BU607521 AV699045 AA343695 BG568159 BV189475 CB117022 AA345111 BG566029 
NM_030754 BV170331 AV657148 BG562970 BX457214 AI084001 BG568021 BG566279 
BG562438 AV655850 BG568344 BG617344 AI659145 BG617482 BG618861 CR541758 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SAA4 expression in normal human tissues (normalized intensities)      SAA4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCAGAGCCT
SAA4 Expression
About this image


SAA4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/10 selected tissues (see all 10) fully expand
 
 Epithelium (Reproductive System)    fully expand to see all 3 entries
         vagina ; squamous epithelial cells   
 
 Testis (Reproductive System)    fully expand to see all 2 entries
         Leydig Cells Testis Interstitium
         testis ; cells in seminiferus ducts   
 
 Kidney (Urinary System)
         kidney ; cells in tubules   
 
 Uterus
         cervix, uterine ; squamous epithelial cells   
 
 Breast (Uncategorized)
         breast ; glandular cells   

See SAA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAA4

SOURCE GeneReport for Unigene cluster: Hs.1955

UniProtKB/Swiss-Prot: SAA4_HUMAN, P35542
Tissue specificity: Expressed by the liver; secreted in plasma

    SABiosciences Expression via Pathway-Focused PCR Array including SAA4: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SAA4
OriGene qSTAR qPCR primer pairs in human, mouse for SAA4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAA4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAA4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAA4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SAA4 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Saa45 serum amyloid A 4   --   7 (30.53 cM) 46728017 
chicken
(Gallus gallus)
Aves HPS56
Serum amyloid A protein
46(a)
1 → many
5(11869291-11871121)
zebrafish
(Danio rerio)
Actinopterygii saa6
serum amyloid A
47(a)
1 → many
7(13776635-13782564)


ENSEMBL Gene Tree for SAA4 (if available)
TreeFam Gene Tree for SAA4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SAA4 gene
SAA12  SAA22  
3 SIMAP similar genes for SAA4 using alignment to 1 protein entry:     SAA4_HUMAN:
HuSAA1g    SAA2    SAA1

SAA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

1 SNPs in SAA4 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0518934
----see VAR_0518932 C Y mis40--------

HapMap Linkage Disequilibrium report for SAA4 (18252896 - 18258440 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SAA4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv519650CNV Loss19592680

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SAA4
DNA2.0 Custom Variant and Variant Library Synthesis for SAA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 104752    OMIM disorders: --

20/41 diseases for SAA4 (see all 41):    About MalaCards
amyloidosis, renal    secondary amyloidosis    appendicitis    intermittent claudication
familial mediterranean fever    relapsing-remitting multiple sclerosis    severe acute respiratory syndrome    acute myocardial infarction
amyloidosis    myocardial infarction    meningitis    sickle cell disease
leiomyosarcoma    behcet's disease    pneumonia    eosinophilia
vasculitis    periodontal disease    proteinuria    thrombosis

1 disease from the University of Copenhagen DISEASES database for SAA4:
Amyloidosis

SAA4 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/32 Novoseek inferred disease relationships for SAA4 gene (see all 32)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
response acute phase 79.7 5 1995703 (1), 10191288 (1), 10361047 (1), 9040576 (1) (see all 5)
amyloidosis secondary 78.8 3 8804360 (1), 9800479 (1), 19740371 (1)
amyloidosis 77.4 17 18379834 (2), 11454373 (2), 1691798 (1), 12270922 (1) (see all 15)
amyloidosis systemic 70.9 1 17062163 (1)
inflammation 63.1 33 1958088 (2), 10361047 (2), 8137804 (1), 11166375 (1) (see all 29)
familial mediterranean fever 60.9 1 12942707 (1)
rheumatoid arthritis 51.8 7 8804360 (1), 9002005 (1), 1691798 (1), 12270922 (1) (see all 7)
renal amyloidosis 47.2 1 12751000 (1)
amyloid deposition 47 1 16172171 (1)
atherosclerosis 38.6 6 11809924 (1), 12270922 (1), 16477056 (1), 10418738 (1) (see all 5)

Genetic Association Database (GAD): SAA4
Human Genome Epidemiology (HuGE) Navigator: SAA4 (6 documents)

Export disorders for SAA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SAA4 gene, integrated from 9 sources (see all 271):
(articles sorted by number of sources associating them with SAA4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. (PubMed id 1740433)1, 2, 9 Whitehead A.S.... Debeer F.C. (1992)
  2. Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4. (PubMed id 1439582)1, 2, 9 Watson G.... Woo P. (1992)
  3. Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry. (PubMed id 8783012)1, 2, 9 Ducret A.... Aebersold R. (1996)
  4. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute- phase serum amyloid A protein gene (SAA2). (PubMed id 7686132)1, 2, 9 Steel D.M....Whitehead A.S. (1993)
  5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  6. Common genetic variation in multiple metabolic pathwa ys influences susceptibility to low HDL-cholesterol and coronary heart disease. (PubMed id 20855565)1, 4 Peloso G.M....Brousseau M.E. (2010)
  7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  9. Localization of four human serum amyloid A (SAA) protein superfamily genes to chromosome 11p: characterization of a fifth SAA-related gene sequence. (PubMed id 8325654)1, 3 Sellar G.C. and Whitehead A.S. (1993)
  10. Characterization of constitutive human serum amyloid A protein (SAA4) as an apolipoprotein. (PubMed id 7775864)1, 9 de Beer M.C....de Beer F.C. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6291 HGNC: 10516 AceView: SAA4andSAA2 Ensembl:ENSG00000148965 euGenes: HUgn6291
ECgene: SAA4 H-InvDB: SAA4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SAA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SAA4 gene:
Search GeneIP for patents involving SAA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for SAA4 (Serum Amyloid A4)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for SAA4   OriGene RNAi products in human, mouse, rat for SAA4  
 OriGene qPCR primer pairs and template standards for SAA4   OriGene Protein Over-expression Lysate for SAA4  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for SAA4  
 OriGene qSTAR qPCR primer pairs in human, mouse for SAA4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for SAA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SAA4   OriGene Custom Protein Services for SAA4  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAA4
 QIAGEN SeqTarget long-range PCR primers for resequencing SAA4
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAA4
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAA4
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAA4
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAA4
 GenScript Custom Purified and Recombinant Proteins Services for SAA4 GenScript cDNA clones with any tag delivered in your preferred vector for SAA4
 GenScript Custom Assay Services for SAA4 GenScript Custom Superior Antibodies Services for SAA4
 GenScript Custom overexpressing Cell Line Services for SAA4 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in SAA4 promoter
 Search Chromatin IP Primers for SAA4
 RT2 qPCR Primer Assay in human, mouse, rat SAA4
 Search GNC Networks for SAA4
 SABiosciences PCR Arrays including human, mouse, rat SAA4
 Search Tocris compounds for SAA4
 Proteins and Antibodies for SAA4
 Browse Sino Biological Cell Lysates
 cDNA Clones for SAA4
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 SAA4 antibodies
 SAA4 proteins
 SAA4 lysates
 Antibodies for SAA4
 See all of Abcam's Antibodies, Kits and Proteins for SAA4
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for SAA4




 Proteins for SAA4
 Antibodies for SAA4
 ELISAs for SAA4
 CLIAs for SAA4
 Search LifeMap BioReagents cell lines for SAA4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAA4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for SAA4
 SwitchGear Promoter luciferase reporter plasmids for SAA4
 ThermoFisher Antibodies for SAA4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAA4
 inGenious Targeting Laboratory - Custom generated mouse model solutions for SAA4
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAA4
Customized:
 lentivirus for stable overexpression of SAA4
 lentivirus expression plasmids for stable overexpression of SAA4
 adenovirus for overexpression of SAA4
 LSBio Antibodies in human, mouse, rat for SAA4
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SAA4 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4