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Aliases for SAA2-SAA4 Gene

Aliases for SAA2-SAA4 Gene

  • SAA2-SAA4 Readthrough 2 3 5

External Ids for SAA2-SAA4 Gene

Previous GeneCards Identifiers for SAA2-SAA4 Gene

  • GC11U901751
  • GC11M018254
  • GC11M018232

Summaries for SAA2-SAA4 Gene

Entrez Gene Summary for SAA2-SAA4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring serum amyloid A2 and serum amyloid A4 genes on chromosome 11. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]

GeneCards Summary for SAA2-SAA4 Gene

SAA2-SAA4 (SAA2-SAA4 Readthrough) is a Protein Coding gene. An important paralog of this gene is SAA4.

Additional gene information for SAA2-SAA4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAA2-SAA4 Gene

Genomics for SAA2-SAA4 Gene

GeneHancer (GH) Regulatory Elements for SAA2-SAA4 Gene

Promoters and enhancers for SAA2-SAA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I018249 Promoter 0.7 EPDnew 550.8 +0.0 19 0.1 JUND MAX RNA5SP333 SAA2-SAA4 SAA2
GH11I018248 Promoter 0.5 EPDnew 550.8 +0.6 612 0.1 RNA5SP333 SAA2 SAA2-SAA4 GC11M018180
GH11I018245 Enhancer 0.9 Ensembl ENCODE 0.8 +2.2 2155 1.8 NR2F1 JUNB EBF1 ELF1 DPF2 BATF IRF4 TARDBP IKZF1 NBN RNA5SP333 USH1C SAA2 SAA2-SAA4 GC11M018180
GH11I018243 Enhancer 0.7 ENCODE 0.8 +4.7 4745 0.2 ELF3 CTCF RAD21 RELA TEAD3 GATA3 GATA2 SMC3 ZNF143 ETV6 RNA5SP333 SAA2-SAA4 GC11M018180 SAA2
GH11I018236 Promoter/Enhancer 1.4 EPDnew ENCODE 0.4 +11.4 11420 1.6 ELF3 FOXA2 MLX ARID4B THRB RAD21 RARA YY1 ATF7 CREM GC11M018180 SAA4 LDHC TMEM86A LOC100129966 SAA2-SAA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAA2-SAA4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SAA2-SAA4 Gene

Genomic Locations for SAA2-SAA4 Gene
chr11:18,231,355-18,248,674
(GRCh38/hg38)
Size:
17,320 bases
Orientation:
Minus strand
chr11:18,252,902-18,270,221
(GRCh37/hg19)

Genomic View for SAA2-SAA4 Gene

Genes around SAA2-SAA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAA2-SAA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAA2-SAA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAA2-SAA4 Gene

Proteins for SAA2-SAA4 Gene

  • Protein details for SAA2-SAA4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A096LPE2
    Recommended name:
    SAA2-SAA4 readthrough
    Protein Accession:
    A0A096LPE2

    Protein attributes for SAA2-SAA4 Gene

    Size:
    208 amino acids
    Molecular mass:
    23353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAA2-SAA4 Gene

Post-translational modifications for SAA2-SAA4 Gene

No Post-translational modifications

Other Protein References for SAA2-SAA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAA2-SAA4 Gene

Domains & Families for SAA2-SAA4 Gene

Gene Families for SAA2-SAA4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SAA2-SAA4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAA2-SAA4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SAA2-SAA4 Gene

Function for SAA2-SAA4 Gene

Phenotypes From GWAS Catalog for SAA2-SAA4 Gene

Gene Ontology (GO) - Molecular Function for SAA2-SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042056 chemoattractant activity IBA --
genes like me logo Genes that share ontologies with SAA2-SAA4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAA2-SAA4 Gene

Localization for SAA2-SAA4 Gene

Gene Ontology (GO) - Cellular Components for SAA2-SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SAA2-SAA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SAA2-SAA4 Gene

Pathways & Interactions for SAA2-SAA4 Gene

SuperPathways for SAA2-SAA4 Gene

No Data Available

Interacting Proteins for SAA2-SAA4 Gene

Gene Ontology (GO) - Biological Process for SAA2-SAA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050918 positive chemotaxis IEA --
GO:0060326 cell chemotaxis IBA --
genes like me logo Genes that share ontologies with SAA2-SAA4: view

No data available for Pathways by source and SIGNOR curated interactions for SAA2-SAA4 Gene

Drugs & Compounds for SAA2-SAA4 Gene

No Compound Related Data Available

Transcripts for SAA2-SAA4 Gene

mRNA/cDNA for SAA2-SAA4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAA2-SAA4 Gene

No ASD Table

Relevant External Links for SAA2-SAA4 Gene

GeneLoc Exon Structure for
SAA2-SAA4
ECgene alternative splicing isoforms for
SAA2-SAA4

Expression for SAA2-SAA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAA2-SAA4 Gene

mRNA differential expression in normal tissues according to GTEx for SAA2-SAA4 Gene

This gene is overexpressed in Liver (x49.4).
genes like me logo Genes that share expression patterns with SAA2-SAA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAA2-SAA4 Gene

Orthologs for SAA2-SAA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SAA2-SAA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAA4 33
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia SAA4 33
  • 75.97 (n)
rat
(Rattus norvegicus)
Mammalia Saa4 33
  • 72.82 (n)
mouse
(Mus musculus)
Mammalia Saa4 33 16
  • 71.54 (n)
Species where no ortholog for SAA2-SAA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAA2-SAA4 Gene

ENSEMBL:
Gene Tree for SAA2-SAA4 (if available)
TreeFam:
Gene Tree for SAA2-SAA4 (if available)

Paralogs for SAA2-SAA4 Gene

Paralogs for SAA2-SAA4 Gene

genes like me logo Genes that share paralogs with SAA2-SAA4: view

Variants for SAA2-SAA4 Gene

Sequence variations from dbSNP and Humsavar for SAA2-SAA4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000157604 -- 18,246,593(-) A/T intron_variant
rs1000208051 -- 18,246,471(-) G/A intron_variant
rs1000319066 -- 18,233,677(-) AA/AAA intron_variant
rs1000390383 -- 18,240,393(-) G/A intron_variant
rs1000414249 -- 18,236,392(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAA2-SAA4 Gene

Variant ID Type Subtype PubMed ID
nsv519650 CNV loss 19592680
nsv982990 CNV duplication 23825009

Additional Variant Information for SAA2-SAA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAA2-SAA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SAA2-SAA4 Gene

Disorders for SAA2-SAA4 Gene

Additional Disease Information for SAA2-SAA4

No disorders were found for SAA2-SAA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAA2-SAA4 Gene

Publications for SAA2-SAA4 Gene

  1. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 3 58
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58

Products for SAA2-SAA4 Gene

Sources for SAA2-SAA4 Gene

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