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Aliases for SAA2 Gene

Aliases for SAA2 Gene

  • Serum Amyloid A2 2 3

External Ids for SAA2 Gene

Summaries for SAA2 Gene

GeneCards Summary for SAA2 Gene

SAA2 (Serum Amyloid A2) is a Protein Coding gene. Diseases associated with SAA2 include secondary amyloidosis and pertussis. Among its related pathways are Selenium Pathway and Folate Metabolism. An important paralog of this gene is SAA4.

UniProtKB/Swiss-Prot for SAA2 Gene

  • Major acute phase reactant. Apolipoprotein of the HDL complex

Gene Wiki entry for SAA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAA2 Gene

Genomics for SAA2 Gene

Genomic Location for SAA2 Gene

Start:
18,238,233 bp from pter
End:
18,248,674 bp from pter
Size:
10,442 bases
Orientation:
Minus strand

Genomic View for SAA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAA2 Gene

Regulatory Elements for SAA2 Gene

Proteins for SAA2 Gene

  • Protein details for SAA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJI9-SAA2_HUMAN
    Recommended name:
    Serum amyloid A-2 protein
    Protein Accession:
    P0DJI9
    Secondary Accessions:
    • G3XAK9
    • P02735
    • P02736
    • P02737
    • Q16730
    • Q16834
    • Q16835
    • Q16879
    • Q3KRB3
    • Q6FG67
    • Q96QN0
    • Q9UCK9
    • Q9UCL0

    Protein attributes for SAA2 Gene

    Size:
    122 amino acids
    Molecular mass:
    13527 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAA2 Gene

Proteomics data for SAA2 Gene at MOPED

Post-translational modifications for SAA2 Gene

  • This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAA2 Gene

No data available for DME Specific Peptides for SAA2 Gene

Domains for SAA2 Gene

Protein Domains for SAA2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SAA2_HUMAN
Family:
  • Belongs to the SAA family.:
    • P0DJI9
genes like me logo Genes that share domains with SAA2: view

No data available for Gene Families for SAA2 Gene

Function for SAA2 Gene

Molecular function for SAA2 Gene

GENATLAS Biochemistry: serum amyloid A,2,acute phase reactant
UniProtKB/Swiss-Prot Function: Major acute phase reactant. Apolipoprotein of the HDL complex
UniProtKB/Swiss-Prot Induction: Upon cytokine stimulation

Gene Ontology (GO) - Molecular Function for SAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042056 chemoattractant activity IBA --
genes like me logo Genes that share ontologies with SAA2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SAA2 Gene

Localization for SAA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAA2 Gene COMPARTMENTS Subcellular localization image for SAA2 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
GO:0034364 high-density lipoprotein particle IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SAA2: view

Pathways for SAA2 Gene

genes like me logo Genes that share pathways with SAA2: view

Pathways by source for SAA2 Gene

3 BioSystems pathways for SAA2 Gene

Interacting Proteins for SAA2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256733%0d%0a9606.ENSP00000374309%0d%0a9606.ENSP00000364979%0d%0a9606.ENSP00000236850%0d%0a
Selected Interacting proteins: ENSP00000256733 for SAA2 Gene via STRING

Gene Ontology (GO) - Biological Process for SAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0050918 positive chemotaxis IBA --
GO:0060326 cell chemotaxis IBA --
genes like me logo Genes that share ontologies with SAA2: view

Compounds for SAA2 Gene

(1) Novoseek inferred chemical compound relationships for SAA2 Gene

Compound -log(P) Hits PubMed IDs
dexamethasone 21.1 1
genes like me logo Genes that share compounds with SAA2: view

Transcripts for SAA2 Gene

Unigene Clusters for SAA2 Gene

Serum amyloid A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAA2 Gene

No ASD Table

Relevant External Links for SAA2 Gene

GeneLoc Exon Structure for
SAA2
ECgene alternative splicing isoforms for
SAA2

Expression for SAA2 Gene

mRNA expression in normal human tissues for SAA2 Gene

mRNA differential expression in normal tissues according to GTEx for SAA2 Gene

This gene is overexpressed in Liver (49.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SAA2 Gene

SOURCE GeneReport for Unigene cluster for SAA2 Gene Hs.731376

mRNA Expression by UniProt/SwissProt for SAA2 Gene

P0DJI9-SAA2_HUMAN
Tissue specificity: Expressed by the liver; secreted in plasma
genes like me logo Genes that share expressions with SAA2: view

Orthologs for SAA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAA2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAA1 37
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 66 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Saa2 37
  • 69 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 66 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii saa 37
  • 59 (a)
OneToMany
Species with no ortholog for SAA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAA2 Gene

ENSEMBL:
Gene Tree for SAA2 (if available)
TreeFam:
Gene Tree for SAA2 (if available)

Paralogs for SAA2 Gene

Paralogs for SAA2 Gene

Selected SIMAP similar genes for SAA2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SAA2 Gene

genes like me logo Genes that share paralogs with SAA2: view

Variants for SAA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SAA2 Gene

P0DJI9-SAA2_HUMAN
At least 2 different SAA2 alleles have been described: SAA2.1 (SAA2alpha) and SAA2.2 (SAA2beta). We use here the revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA2.2

Sequence variations from dbSNP and Humsavar for SAA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_006930 -

Relevant External Links for SAA2 Gene

HapMap Linkage Disequilibrium report
SAA2
Human Gene Mutation Database (HGMD)
SAA2

No data available for Structural Variations from Database of Genomic Variants (DGV) for SAA2 Gene

Disorders for SAA2 Gene

UniProtKB/Swiss-Prot

SAA2_HUMAN
  • Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA2 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269 PubMed:1463770}.

(3) University of Copenhagen DISEASES for SAA2 Gene

(8) Novoseek inferred disease relationships for SAA2 Gene

Disease -log(P) Hits PubMed IDs
amyloidosis secondary 79 1
renal amyloidosis 72.6 5
amyloidosis 61.4 1
familial mediterranean fever 61.3 2
response acute phase 57 2

Relevant External Links for SAA2

Genetic Association Database (GAD)
SAA2
Human Genome Epidemiology (HuGE) Navigator
SAA2
genes like me logo Genes that share disorders with SAA2: view

Publications for SAA2 Gene

  1. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute- phase serum amyloid A protein gene (SAA2). (PMID: 7686132) Steel D.M. … Whitehead A.S. (Genomics 1993) 2 3 23
  2. Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. (PMID: 15170927) Bakkaloglu A. … Yilmaz E. (J. Rheumatol. 2004) 3 23 49
  3. The frequencies of the serum amyloid A2 alleles in healthy (Turkish, Azerbaijan and Kazakh) populations. (PMID: 16152805) TaA9tan H. … Tuzun A. (Genetika 2005) 3 23 49
  4. Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study. (PMID: 19729864) Carty C.L. … Reiner A.P. (J. Atheroscler. Thromb. 2009) 3 23 49
  5. The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells. (PMID: 1656519) Betts J. … Woo P. (Scand. J. Immunol. 1991) 3 4

Products for SAA2 Gene

Sources for SAA2 Gene

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