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SAA2 Gene

protein-coding   GIFtS: 54

GC11M018223
serum amyloid A2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for SAA2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
SAA 3
Descriptions
serum amyloid A2 2
External Ids
HGNC: 105141
Entrez Gene: 62892
UniProtKB: P027353
Ensembl: ENSG000001343397
Search outside databases for aliases for SAA2 gene

Previous GC identifers: GC11M019387 GC11M019209 GC11M018293 GC11M018231

Summaries
for SAA2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
Function: Major acute phase reactant. Apolipoprotein of the HDL complex

Gene Wiki entry for SAA2

Genomic Location
for SAA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SAA2 gene  

Entrez Gene cytogenetic band: 11p15.1-p14   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1-p14

SAA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018223:     (about GC identifiers)

Start:
 18,223,365 bp from pter
End:
 18,226,758 bp from pter
Size:
 3,394 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  

Proteins
for SAA2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SAA_HUMAN, P02735 (See protein sequence)
Recommended Name: Serum amyloid A protein precursor  
Size: 122 amino acids; 13532 Da
Subcellular location: Secreted
Mass spectrometry: Mass=11702; Mass_error=14; Method=MALDI; Range=19-122; Source=PubMed:12973732;
Mass spectrometry: Mass=11682.7; Method=MALDI; Range=19-122; Source=PubMed:12606051;
Mass spectrometry: Mass=11526.5; Method=MALDI; Range=20-122; Source=PubMed:12606051;
Mass spectrometry: Mass=11439.6; Method=MALDI; Range=21-122; Source=PubMed:12606051;
Mass spectrometry: Mass=11363.6; Method=MALDI; Range=20-121; Source=PubMed:12606051;
Mass spectrometry: Mass=11235.6; Method=MALDI; Range=20-120; Source=PubMed:12606051;
Mass spectrometry: Mass=10872.6; Method=MALDI; Range=22-119; Source=PubMed:12606051;
Mass spectrometry: Mass=8337.5; Mass_error=0.8; Method=Electrospray; Range=19-94; Note=With
variants Ala-70, Val-75, Asn-78 and 86-Leu-Thr-87; Source=PubMed:1463770;
Mass spectrometry: Mass=8390.9; Mass_error=0.2; Method=Electrospray; Range=19-94; Note=With variant
Ala-70; Source=PubMed:1463770;
Miscellaneous: Elevated serum SSA protein levels may be associated with lung cancer
Secondary accessions: P02736 P02737 Q16730 Q16834 Q16835 Q16879 Q3KRB3 Q6FG67 Q96QN0 Q9UCK9 Q9UCL0

Post-translational modifications:

  • This protein is the precursor of amyloid protein A, which is formed by the removal of approximately
    24 residues from the C-terminal end1


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001120852.1  NP_110381.2  


    ENSEMBL proteins: 
    ENSP00000256733 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Serum Amyloid A)
    Human Recombinant Proteins from Abnova (SAA2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for SAA2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Serum Amyloid A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SAA2)
    Novus Biologicals Antibody for SAA2

    Assays for SAA2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for SAA2

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR000096 Serum_amyloid_A


       GeneDecks  SAA2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P02735

    ProtoNet protein and cluster: P02735

    1 Blocks protein family: IPB000096 Serum amyloid A protein

    UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
    Similarity: Belongs to the SAA family

    Gene Function
    for SAA2

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SAA2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SAA2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_030754

                  Applied Biosystems Silencer® siRNAs for SAA2

                  Sigma-Aldrich siRNA and siRNA Panels for SAA2  
                         Sigma-Aldrich shRNA for SAA2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127380
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127380
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001127380 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_030754

    UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
    Function: Major acute phase reactant. Apolipoprotein of the HDL complex
    Induction: Upon cytokine stimulation

    Genatlas biochemistry entry for SAA2:
    serum amyloid A,2,acute phase reactant

    Pathways & Interactions
    for SAA2

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for SAA2 (Maps provided by GeneGo):
     The role of amyloid proteins in cell adhesion

       GeneDecks  SAA2 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SAA2  (Your Favorite Gene powered by Ingenuity) 
     Acute Phase Response Signaling

       GeneDecks  SAA2 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  SAA2 


    5/9 Interacting proteins for SAA2 (ENSP000002567333) via UniProtKB, MINT, and/or STRING (see all 9 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6ENSP000002587433STRING (score=.864)
    FPR2ENSP000003401913STRING (score=.848)
    IL22ENSP000003293843STRING (score=.803)
    IL1BENSP000002633413STRING (score=.802)
    IL10ENSP000003560663STRING (score=.75)
    About this table

    Drugs & Compounds
    for SAA2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SAA2
    1 PharmGKB drug compound relationship for SAA2 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    dexamethasoneFA  12077270 12938239
    About this table


    Transcripts
    for SAA2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SAA2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SAA2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_030754

                  Sigma-Aldrich siRNA and siRNA Panels for SAA2  
                         Sigma-Aldrich shRNA for SAA2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001127380  NM_030754  

    REFSEQ mRNAs for SAA2 gene (2 alternative transcripts): 

    NM_001127380.1   NM_030754.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001127380  NM_030754  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127380
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127380
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001127380 

    Additional cDNA sequence: 

    AK307163.1 BC020795.1 M23699.1 M23700.1 M26152.1 X51440.1 X51444.1 X51445.1 

    18 DOTS entries:

    DT.75101001  DT.95149902  DT.91774145  DT.95149914  DT.100837685  DT.65287444  DT.75107310  DT.91774134 
    DT.95149907  DT.100797172  DT.101984537  DT.120705477  DT.91676281  DT.91774130  DT.95149906  DT.100797171 
    DT.120759598  DT.91906861 

    24/249 AceView cDNA sequences (see all 249 ):

    AV699045 BU607521 AA343695 M23700 BX283962 BG568021 BG618424 BG569644 
    R83510 BF126524 AI659145 AV657148 BG617344 NM_006512 BG618907 BG567151 
    BV169293 AA345111 AV655850 BU685219 BG569107 BG568520 BC020795 BC007026 

    highest scoring ESTs for SAA2:

    BC020795 BG533282 BG545040 BG545113 BG545142 BG562438 BG562467 BG562499 BG562536 BG562760 

    Unigene Cluster for SAA2:

    Serum amyloid A2
    Hs.1955  [show with all ESTs]
    Unigene Representative Sequence: NM_001127380


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000256733  

    Expression
    for SAA2

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SAA2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SAA2

    1 / 2 / 3

    5 probe-sets matching SAA2 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33272_at2, 3 U95-A 2 1.00 0.50 1.00 1.00 AA829286 0.40 0.20 0.32 2

    		208607_s_at2, 3 U133-A 2 1.00 0.50 -- -- NM_030754 0.60 0.83 0.73 1

    		214456_x_at2, 3 U133-A 3 0.73 0.48 -- -- M23699 0.60 0.83 0.73 1

    		208607_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --

    		214456_x_at2 U133Plus2 3 0.73 0.48 -- -- -- -- -- -- --
    GeneDecks  SAA2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.1955

    UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
    Tissue specificity: Expressed by the liver; secreted in plasma

    Orthologs
    for SAA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SAA2 gene from 1 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    mouse
    (Mus musculus)    		 Saa11   -- serum amyloid A 1 74.59(n)
    68.85(a)    		 20208  NM_009117.3  NP_033143.1 
    About this table        Species with no ortholog for SAA2

    ENSEMBL Gene Tree for SAA2

    Paralogs
    for SAA2

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SAA2 gene
    SAA3P2  SAA12  SAA42  

    SNPs/Variants
    for SAA2

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
    Polymorphism: Both SAA1 and SAA2 have a number of alleles. We use here the nomenclature of
    PubMed:1546977. The sequence shown is that of 1-alpha


    10/46 NCBI SNPs in SAA2 are shown (see all 46 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 39)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs24688441,2
    		A,C,F,H,O18223603(-) AGGCCA/GTGGTG 1 R/H mis112Minor allele frequency- G:0.19NA EU EA WA 1056
    rs79440021,2
    		A,C,F,H18228549(+) TTGATC/ATCAAA 1 -- ng316Minor allele frequency- A:0.05EU EA NA 422
    rs71303371,2
    		A,C,F,H18227181(+) CTGAAG/ATCCCT 1 -- ng318Minor allele frequency- A:0.42EU EA WA 838
    rs79332801,2
    		A,C,F,H18228505(+) AACTGT/GTTTCC 1 -- ng316Minor allele frequency- G:0.08EU EA NA 438
    rs38250231,2
    		C,F,H18227245(+) CATCTC/TATGTG 1 -- ng318Minor allele frequency- T:0.27EU EA WA 840
    rs37589461,2
    		C,F,H18227474(+) GGGGAC/TGTGCC 1 -- ng315Minor allele frequency- T:0.08EA EU WA 1886
    rs110245761,2
    		F,H18217779(+) TTCTGG/AAACAC 1 -- ut314Minor allele frequency- A:0.18EU EA WA 418
    --
    rs18697841,2
    		A18227904(+) AAAAAA/TTTTTT 1 -- ng310--------
    rs71137371,2
    		H18217410(+) tcaggT/Gttttt 1 -- ut314Minor allele frequency- G:0.00EU EA WA 420
    --
    rs24688171,2
    		H18226772(-) CCACCT/GCTCCC 1 -- ng314Minor allele frequency- G:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for SAA2 (up to first 250kb)

    Disorders & Mutations
    for SAA2

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 104751

    UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
  • Reactive, secondary amyloidosis is characterized by the extracellular accumulation in
    various tissues of the SAA protein. These deposits are highly insoluble and resistant to
    proteolysis; they disrupt tissue structure and compromise function
  • BOL is from a patient with Waldenstrom macroglobulinemia
  • JL is from a patient with ankylosing spondylitis
  • TH is from a patient with juvenile rheumatoid arthritis

    • 8 Novoseek disease relationships for SAA2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis secondary 79.94 1 16152805 (1)
    renal amyloidosis 73.58 5 15170927 (3), 11017802 (2)
    familial mediterranean fever 63.04 2 15170927 (2)
    amyloidosis 62.82 1 14696796 (1)
    response acute phase 58.20 2 8244997 (1), 12938239 (1)
    amyloid deposition 49.36 1 8268220 (1)
    necrosis 6.34 1 18175929 (1)
    tumors 0.00 1 18175929 (1)
    About this table

    1 PharmGKB disease relationship for SAA2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    AmyloidosisFA  12077270 12938239
    About this table

    Genetic Association Database: SAA2
    Human Genome Epidemiology Navigator: SAA2 (6 documents)

    Medical News
    for SAA2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SAA2

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/79 PubMed articles for SAA2 gene (see all 79 ):

    Search for SAA2

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SAA2

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6289 HGNC: 10514 AceView: SAA4andSAA2 Ensembl:ENSG00000134339 euGenes: HUgn6289
    ECgene: SAA2 H-InvDB: SAA2

    Other Databases showing SAA2

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SAA2

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for SAA2

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SAA2

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SAA2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SAA2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SAA2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SAA2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Serum Amyloid A)
     Antibodies (Serum Amyloid A)
     Search OriGene for SAA2
     Search Tocris compounds for SAA2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for SAA2

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