Aliases for SAA1 Gene
External Ids for SAA1 Gene
Previous Symbols for SAA1 Gene
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
GeneCards Summary for SAA1 Gene
SAA1 (Serum Amyloid A1) is a Protein Coding gene. Diseases associated with SAA1 include secondary amyloidosis and splenic artery aneurysm. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include G-protein coupled receptor binding. An important paralog of this gene is SAA2.
UniProtKB/Swiss-Prot for SAA1 Gene
Major acute phase protein