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Aliases for SAA1 Gene

Aliases for SAA1 Gene

  • Serum Amyloid A1 2 3
  • SAA 3 4
  • Tumor Protein P53 Inducible Protein 4 3
  • Serum Amyloid A Protein 3
  • TP53I4 3
  • PIG4 3
  • SAA2 3

External Ids for SAA1 Gene

Previous HGNC Symbols for SAA1 Gene

  • SAA

Previous GeneCards Identifiers for SAA1 Gene

  • GC11P019408
  • GC11P019230
  • GC11P018326
  • GC11P018252
  • GC11P018244
  • GC11P018287
  • GC11P017970

Summaries for SAA1 Gene

Entrez Gene Summary for SAA1 Gene

  • This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]

GeneCards Summary for SAA1 Gene

SAA1 (Serum Amyloid A1) is a Protein Coding gene. Diseases associated with SAA1 include amyloidosis aa and splenic artery aneurysm. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include heparin binding and chemoattractant activity. An important paralog of this gene is SAA2.

UniProtKB/Swiss-Prot for SAA1 Gene

  • Major acute phase protein

Gene Wiki entry for SAA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAA1 Gene

Genomics for SAA1 Gene

Regulatory Elements for SAA1 Gene

Genomic Location for SAA1 Gene

Chromosome:
11
Start:
18,266,174 bp from pter
End:
18,269,977 bp from pter
Size:
3,804 bases
Orientation:
Plus strand

Genomic View for SAA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAA1 Gene

Proteins for SAA1 Gene

  • Protein details for SAA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJI8-SAA1_HUMAN
    Recommended name:
    Serum amyloid A-1 protein
    Protein Accession:
    P0DJI8
    Secondary Accessions:
    • P02735
    • P02736
    • P02737
    • Q16730
    • Q16834
    • Q16835
    • Q16879
    • Q3KRB3
    • Q6FG67
    • Q96QN0
    • Q9UCK9
    • Q9UCL0

    Protein attributes for SAA1 Gene

    Size:
    122 amino acids
    Molecular mass:
    13532 Da
    Quaternary structure:
    • Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin.

    Three dimensional structures from OCA and Proteopedia for SAA1 Gene

neXtProt entry for SAA1 Gene

Proteomics data for SAA1 Gene at MOPED

Post-translational modifications for SAA1 Gene

  • This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAA1 Gene

Antibody Products

  • R&D Systems Antibodies for SAA1 (Serum Amyloid A1)

No data available for DME Specific Peptides for SAA1 Gene

Domains & Families for SAA1 Gene

Gene Families for SAA1 Gene

Protein Domains for SAA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAA1 Gene

Graphical View of Domain Structure for InterPro Entry

P0DJI8

UniProtKB/Swiss-Prot:

SAA1_HUMAN :
  • Belongs to the SAA family.
Family:
  • Belongs to the SAA family.
genes like me logo Genes that share domains with SAA1: view

Function for SAA1 Gene

Molecular function for SAA1 Gene

GENATLAS Biochemistry:
serum amyloid A,1,acute phase reactant,susceptibility gene for juvenile chronic arthritis and AA amyloidosis
UniProtKB/Swiss-Prot Function:
Major acute phase protein
UniProtKB/Swiss-Prot Induction:
Upon cytokine stimulation

Gene Ontology (GO) - Molecular Function for SAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IDA 9892621
GO:0008201 heparin binding IEA --
GO:0042056 chemoattractant activity IBA --
genes like me logo Genes that share ontologies with SAA1: view

Phenotypes for SAA1 Gene

genes like me logo Genes that share phenotypes with SAA1: view

Animal Models for SAA1 Gene

MGI Knock Outs for SAA1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SAA1 Gene

Localization for SAA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAA1 Gene COMPARTMENTS Subcellular localization image for SAA1 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 4
lysosome 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005829 cytosol NAS 7561109
GO:0005881 cytoplasmic microtubule IDA 22131810
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with SAA1: view

Pathways & Interactions for SAA1 Gene

SuperPathways for SAA1 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Cytosolic sensors of pathogen-associated DNA
3 Peptide ligand-binding receptors
4 Signaling by GPCR
5 Immune System
genes like me logo Genes that share pathways with SAA1: view

Interacting Proteins for SAA1 Gene

Gene Ontology (GO) - Biological Process for SAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 22532826
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006953 acute-phase response NAS 9815279
GO:0007204 positive regulation of cytosolic calcium ion concentration NAS 7561109
GO:0030168 platelet activation NAS 1697614
genes like me logo Genes that share ontologies with SAA1: view

No data available for SIGNOR curated interactions for SAA1 Gene

Drugs & Compounds for SAA1 Gene

(14) Drugs for SAA1 Gene - From: DrugBank, PharmGKB, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Human Serum Albumin Approved Pharma Target 0
rituximab Approved Pharma Therapeutic Antibodies 1514
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 103
Dexamethasone Approved, Investigational Pharma Agonist 1806
Estradiol Approved, Investigational Pharma Sex hormone 1057

(5) Additional Compounds for SAA1 Gene - From: NovoSeek

genes like me logo Genes that share compounds with SAA1: view

Transcripts for SAA1 Gene

Unigene Clusters for SAA1 Gene

Serum amyloid A1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAA1 Gene

No ASD Table

Relevant External Links for SAA1 Gene

GeneLoc Exon Structure for
SAA1
ECgene alternative splicing isoforms for
SAA1

Expression for SAA1 Gene

mRNA expression in normal human tissues for SAA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAA1 Gene

This gene is overexpressed in Liver (x46.5).

Protein differential expression in normal tissues from HIPED for SAA1 Gene

This gene is overexpressed in Lavage (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAA1 Gene



SOURCE GeneReport for Unigene cluster for SAA1 Gene Hs.632144

mRNA Expression by UniProt/SwissProt for SAA1 Gene

P0DJI8-SAA1_HUMAN
Tissue specificity: Expressed by the liver; secreted in plasma (at protein level).
genes like me logo Genes that share expression patterns with SAA1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein tissue co-expression partners for SAA1 Gene

Orthologs for SAA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAA2 35
  • 83.75 (n)
  • 83.47 (a)
-- 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100684663 35
  • 82.24 (n)
  • 81.97 (a)
SAA1 36
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Saa1 35
  • 76.5 (n)
  • 72.95 (a)
Saa1 16
Saa3 36
  • 70 (a)
ManyToMany
Saa1 36
  • 71 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SAA1 35
  • 99.18 (n)
  • 97.54 (a)
SAA1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii saa 35
  • 61.71 (n)
  • 57.85 (a)
saa 36
  • 57 (a)
OneToMany
Species with no ortholog for SAA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAA1 Gene

ENSEMBL:
Gene Tree for SAA1 (if available)
TreeFam:
Gene Tree for SAA1 (if available)

Paralogs for SAA1 Gene

Paralogs for SAA1 Gene

(3) SIMAP similar genes for SAA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SAA1: view

Variants for SAA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SAA1 Gene

P0DJI8-SAA1_HUMAN
At least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3 (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2). We use here the revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA1.1

Sequence variations from dbSNP and Humsavar for SAA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12218 -- 18,269,774(-) TGATC(A/G)GCCAG synonymous-codon, reference
rs15790 -- 18,269,765(+) GAGGA(C/T)TCGCT reference, synonymous-codon
rs750948 -- 18,265,260(-) AGTCC(A/G)TTTTC upstream-variant-2KB
rs750949 -- 18,265,150(-) CCTTC(C/T)TCTCT upstream-variant-2KB
rs1059559 - 18,269,742(+) AGAGA(C/T)TCTTT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SAA1 Gene

Variant ID Type Subtype PubMed ID
esv1009214 CNV Deletion 20482838
esv1646005 CNV Deletion 17803354

Variation tolerance for SAA1 Gene

Residual Variation Intolerance Score: 91.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAA1 Gene

HapMap Linkage Disequilibrium report
SAA1
Human Gene Mutation Database (HGMD)
SAA1

Disorders for SAA1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for SAA1 Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis aa
  • aa amyloidosis
splenic artery aneurysm
  • aneurysm of splenic artery
hyper-igd syndrome
  • hyper igd syndrome
bronchus carcinoma
  • bc - bronchogenic carcinoma
familial mediterranean fever, ar
  • familial mediterranean fever
- elite association
Search SAA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SAA1_HUMAN
  • Note=Elevated serum SAA1 protein levels may be associated with lung cancer. {ECO:0000269 PubMed:1463770}.
  • Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269 PubMed:1463770}.

Relevant External Links for SAA1

Genetic Association Database (GAD)
SAA1
Human Genome Epidemiology (HuGE) Navigator
SAA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAA1
genes like me logo Genes that share disorders with SAA1: view

No data available for Genatlas for SAA1 Gene

Publications for SAA1 Gene

  1. Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin. (PMID: 19369048) Wang Y.C. … Ding S.T. (J. Nutr. Biochem. 2010) 23 67
  2. Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma. (PMID: 19453393) Shinriki S. … Ando Y. (J. Oral Pathol. Med. 2010) 23 67
  3. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. (PMID: 20019678) Samaras K. … Lord R.V. (Obesity (Silver Spring) 2010) 23 67
  4. Does a smaller tract in percutaneous nephrolithotomy contribute to less invasiveness? A prospective comparative study. (PMID: 19800671) Li L.Y. … Lin Z. (Urology 2010) 23 67
  5. Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. (PMID: 19850938) Sullivan C.P. … Schreiber B.M. (J. Biol. Chem. 2010) 23 67

Products for SAA1 Gene

Sources for SAA1 Gene

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