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SAA1 Gene

protein-coding   GIFtS: 60
GCID: GC11P018287

Serum Amyloid A1


(Previous symbol: SAA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serum Amyloid A11 2     TP53I42
SAA1 2 3     Serum Amyloid A Protein2
PIG42     Serum Amyloid A-1 Protein2
SAA22     Tumor Protein P53 Inducible Protein 42

External Ids:    HGNC: 105131   Entrez Gene: 62882   Ensembl: ENSG000001734327   OMIM: 1047505   UniProtKB: P0DJI83   

Export aliases for SAA1 gene to outside databases

Previous GC identifers: GC11P019408 GC11P019230 GC11P018326 GC11P018252 GC11P018244 GC11P017970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SAA1 Gene:
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute
phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an
important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with
chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's
disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in
multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome
11.(provided by RefSeq, Jun 2012)

GeneCards Summary for SAA1 Gene:
SAA1 (serum amyloid A1) is a protein-coding gene. Diseases associated with SAA1 include splenic artery aneurysm, and brucellosis. GO annotations related to this gene include G-protein coupled receptor binding. An important paralog of this gene is SAA2.

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8
Function: Major acute phase reactant. Apolipoprotein of the HDL complex

Gene Wiki entry for SAA1 (Serum amyloid A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAA1 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAA1 promoter sequence
   Search Chromatin IP Primers for SAA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

SAA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018287:  view genomic region     (about GC identifiers)

Start:
18,287,721 bp from pter      End:
18,291,524 bp from pter
Size:
3,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8 (See protein sequence)
Recommended Name: Serum amyloid A-1 protein precursor  
Size: 122 amino acids; 13532 Da
Mass spectrometry: Mass=11702; Mass_error=14; Method=MALDI; Range=19-122; Source=PubMed:12973732;
Mass spectrometry: Mass=11682.7; Method=MALDI; Range=19-122; Source=PubMed:12606051;
Mass spectrometry: Mass=11526.5; Method=MALDI; Range=20-122; Source=PubMed:12606051;
Mass spectrometry: Mass=11439.6; Method=MALDI; Range=21-122; Source=PubMed:12606051;
Mass spectrometry: Mass=11363.6; Method=MALDI; Range=20-121; Source=PubMed:12606051;
Mass spectrometry: Mass=11235.6; Method=MALDI; Range=20-120; Source=PubMed:12606051;
Mass spectrometry: Mass=10872.6; Method=MALDI; Range=22-119; Source=PubMed:12606051;
Mass spectrometry: Mass=8337.5; Mass_error=0.8; Method=Electrospray; Range=19-94; Note=With variants Ala-70,
Val-75, Asn-78 and 86-Leu-Thr-87; Source=PubMed:1463770;
Mass spectrometry: Mass=8390.9; Mass_error=0.2; Method=Electrospray; Range=19-94; Note=With variant Ala-70;
Source=PubMed:1463770;
Secondary accessions: P02735 P02736 P02737 Q16730 Q16834 Q16835 Q16879 Q3KRB3 Q6FG67 Q96QN0
Q9UCK9 Q9UCL0

Explore the universe of human proteins at neXtProt for SAA1: NX_P0DJI8

Explore proteomics data for SAA1 at MOPED

Post-translational modifications: 

  • This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues
    from the C-terminal end1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000322.2  NP_001171477.1  NP_954630.1  

    ENSEMBL proteins: 
     ENSP00000348918   ENSP00000436866   ENSP00000384906  
    Reactome Protein details: P0DJI8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR000096 Serum_amyloid_A

    Graphical View of Domain Structure for InterPro Entry P0DJI8

    ProtoNet protein and cluster: P0DJI8

    UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8
    Similarity: Belongs to the SAA family


    SAA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAA1_HUMAN, P0DJI8
    Function: Major acute phase reactant. Apolipoprotein of the HDL complex
    Induction: Upon cytokine stimulation

         Genatlas biochemistry entry for SAA1:
    serum amyloid A,1,acute phase reactant,susceptibility gene for juvenile chronic arthritis and AA amyloidosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IDA9892621
         
    SAA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Saa1):
     homeostasis/metabolism 

    SAA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Saa1/Saa2Saa1/tm1Itl for SAA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAA1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAA1

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    hsa-mir-34a-5p (MIRT025456)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAA1_HUMAN, P0DJI8: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0034364high-density lipoprotein particle IEA--
    GO:0070062extracellular vesicular exosome IDA19199708
    GO:0071682endocytic vesicle lumen TAS--

    SAA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SAA1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    2Cytosolic sensors of pathogen-associated DNA
    RIP-mediated NFkB activation via ZBP10.81
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex0.52
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Cytosolic sensors of pathogen-associated DNA0.38
    TRAF6 mediated NF-kB activation0.55
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production0.00
    3Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    Peptide ligand-binding receptors0.60
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for SAA1
        Selenium Pathway
    Folate Metabolism
    Vitamin B12 Metabolism


    Selected Reactome Pathways for SAA1 (see all 10)
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    Advanced glycosylation endproduct receptor signaling
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    TRAF6 mediated NF-kB activation
    Amyloids



    SAA1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAA1
    Interactions:

        GeneGlobe Interaction Network for SAA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SAA1 (ENSP000003489184) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748ENSP000003874774STRING: ENSP00000387477
    PRRC2AENSP000003651754STRING: ENSP00000365175
    UBCENSP000003448184STRING: ENSP00000344818
    EIF3FENSP000003100404STRING: ENSP00000310040
    FPR1ENSP000003027074STRING: ENSP00000302707
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006953acute-phase response NAS9815279
    GO:0007204positive regulation of cytosolic calcium ion concentration NAS7561109
    GO:0030168platelet activation NAS1697614
    GO:0030593neutrophil chemotaxis NAS12557751
    GO:0045087innate immune response TAS--

    SAA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SAA1

    2 DrugBank Compounds for SAA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Serum albumin iodonated-- 9048-49-1target--17016423 10361047 17139284 10903648 9200475
    Human Serum Albumin-- 9048-49-1target--17016423 17139284

    Selected Novoseek inferred chemical compound relationships for SAA1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tenidap 60.6 3 7818568 (2), 7780040 (1)
    colchicine 52.8 4 14978665 (2)
    fibrinogen 31.3 9 15515782 (2), 18500463 (2), 1705051 (2), 17103173 (1) (see all 6)
    piroxicam 28.9 2 7818568 (2)
    lipid 21.9 21 18356319 (4), 19369048 (3), 19850938 (1), 15855262 (1) (see all 9)
    dexamethasone 17.8 3 8159722 (1), 8947601 (1)
    cholesterol 17.8 12 10191288 (5), 19223523 (1), 19843373 (1), 9109677 (1) (see all 6)
    simvastatin 12.3 4 11952885 (2), 12398959 (2)
    valine 5.59 2 8512321 (2)
    endotoxin 4.21 3 9295827 (3)



    SAA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SAA1 gene (3 alternative transcripts): 
    NM_000331.4  NM_001178006.1  NM_199161.3  

    Unigene Cluster for SAA1:

    Serum amyloid A1
    Hs.632144  [show with all ESTs]
    Unigene Representative Sequence: BG564669
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356524(uc021qeo.1) ENST00000532858 ENST00000405158(uc021qem.1 uc021qen.1)

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    Additional mRNA sequence: 

    BC007022.1 BC105796.1 CR542241.1 M10906.1 M23698.1 X51439.1 X51443.1 

    9 DOTS entries:

    DT.100797172  DT.120759598  DT.100797170  DT.91774129  DT.120759603  DT.75101001  DT.101984537  DT.95149900 
    DT.91774130 

    Selected AceView cDNA sequences (see all 304):

    AA344934 AL599003 AL598974 BG564393 BG533276 BG616738 H25590 NM_000331 
    BG564472 CD512583 BG563257 BG568516 AA345608 BG565078 CB999100 BQ691948 
    BM856453 BG565310 CD102084 BX457214 BU676268 BV189475 CR542241 BV189929 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SAA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCGGAGGA
    SAA1 Expression
    About this image


    SAA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Colon (Gastrointestinal Tract)
    SAA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632144

    UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8
    Tissue specificity: Expressed by the liver; secreted in plasma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SAA1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Saa11 , 5 serum amyloid A 11, 5 76.5(n)1
    72.95(a)1
      7 (30.54 cM)5
    202081  NM_009117.31  NP_033143.11 
     467405015 
    chicken
    (Gallus gallus)
    Aves --
    Serum amyloid A protein
    65(a)
    1 → many
    5(11869291-11871121) ENSGALG00000027716
    zebrafish
    (Danio rerio)
    Actinopterygii saa1 serum amyloid A 61.71(n)
    57.85(a)
      449557  NM_001005599.1  NP_001005599.1 


    ENSEMBL Gene Tree for SAA1 (if available)
    TreeFam Gene Tree for SAA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAA1 gene
    SAA22  SAA42  
    3 SIMAP similar genes for SAA1 using alignment to 3 protein entries:     SAA1_HUMAN (see all proteins):
    HuSAA1g    SAA2    SAA4

    SAA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    SAA1_HUMAN, P0DJI8: At least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3
    (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2). We use here the
    revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA1.1


    Selected SNPs for SAA1 (see all 229)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11367431,2
    C,F,Hpathogenic118214970(+) GGGTGT/CCTGGG 6 /A /V mis17Minor allele frequency- C:0.36MN NA WA CSA 266
    rs796819111,2
    C,Fpathogenic118215413(+) CCATGG/ATGCGG 6 /D /G mis11Minor allele frequency- A:0.03EA 120
    rs46382891,2
    C,F,A,H--17968466(+) GACCAT/AGAGCT 3 -- us2k118Minor allele frequency- A:0.30NS EA NA WA CSA 854
    rs1863619561,2
    --18209934(+) TTCATG/TCTCTT 3 -- us2k10--------
    rs110245921,2
    C,F--18210140(+) actcaG/Aacata 3 -- us2k19Minor allele frequency- A:0.44NA WA CSA EA 368
    rs24032761,2
    C,A--18210160(-) GGACTA/GCAGTT 3 -- us2k111Minor allele frequency- G:0.37NA WA CSA EA 372
    rs1154925431,2
    C--18210181(+) GGAGGC/TTGAGA 3 -- us2k10--------
    rs348447151,2
    C,F--18210253(+) CTCCAG/ACTCAG 3 -- us2k15Minor allele frequency- A:0.21NA WA 128
    rs28965201,2
    C,F--18210310(-) cctccT/Cctccc 3 -- us2k1 tfbs3 trp37Minor allele frequency- C:0.24NA WA CSA 246
    rs3737294121,2
    C--18210318(+) AGGGC-/AGGGG 
            
    AGGGG
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SAA1 (18287721 - 18291524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SAA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1646005CNV Deletion17803354
    esv1009214CNV Deletion20482838

    Human Gene Mutation Database (HGMD): SAA1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SAA1
    DNA2.0 Custom Variant and Variant Library Synthesis for SAA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 104750    OMIM disorders: --

    UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8
  • Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various
    tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt
    tissue structure and compromise function
  • Note=Elevated serum SAA1 protein levels may be associated with lung cancer

  • Selected diseases for SAA1 (see all 56):    
    About MalaCards
    splenic artery aneurysm    brucellosis    amyloidosis, secondary    familial mediterranean fever
    hyper-igd syndrome    familial cold autoinflammatory syndrome    gastrointestinal system disease    crohn's disease
    amyloidosis    atherosclerosis    rheumatoid arthritis    mastitis
    neuromyelitis optica    acute myocardial infarction    arthritis    sleep apnea
    rheumatic disease    septic shock    aplastic anemia    ankylosing spondylitis

    6 diseases from the University of Copenhagen DISEASES database for SAA1:
    Amyloidosis     Familial Mediterranean fever     Splenic artery aneurysm     Bone marrow disease
    Rheumatoid arthritis     Anemia

    SAA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SAA1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial mediterranean fever 83.1 11 16118480 (1), 17103173 (1), 16888022 (1), 1679035 (1) (see all 7)
    amyloidosis secondary 80.8 8 16236134 (1), 8268220 (1), 11407685 (1), 14733913 (1) (see all 7)
    amyloidosis 80.1 62 14696796 (5), 12762135 (4), 16736418 (3), 11407685 (3) (see all 31)
    renal amyloidosis 74.1 6 11017802 (2), 15170927 (2), 16118480 (1), 14696796 (1)
    response acute phase 72.8 15 10191288 (3), 16236134 (1), 2070782 (1), 9428637 (1) (see all 8)
    rheumatoid arthritis 56.8 23 17039310 (2), 7780041 (2), 11156544 (2), 9002005 (1) (see all 15)
    inflammation 56 28 17103173 (2), 18668591 (2), 19843373 (2), 10455131 (1) (see all 24)
    amyloidosis systemic 46.9 2 10036584 (1), 7504491 (1)
    brucellosis 41.2 1 14978665 (1)
    atherosclerosis 38.7 5 8657133 (1), 19843373 (1), 9109677 (1), 10608507 (1) (see all 5)

    Genetic Association Database (GAD): SAA1
    Human Genome Epidemiology (HuGE) Navigator: SAA1 (23 documents)

    Export disorders for SAA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAA1 gene, integrated from 10 sources (see all 295):
    (articles sorted by number of sources associating them with SAA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. (PubMed id 15170927)1, 4, 9 Bakkaloglu A....Yilmaz E. (J. Rheumatol. 2004)
    2. Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients. (PubMed id 14696796)1, 4, 9 Yilmaz E....BakkaloA9lu A. (Turk. J. Pediatr. 2003)
    3. The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with familial Mediterranean fever. (PubMed id 12687559)1, 4, 9 Gershoni-Baruch R....Livneh A. (Arthritis Rheum. 2003)
    4. An allele of serum amyloid A1 associated with amyloidosis in both Japanese and Caucasians. (PubMed id 12762135)1, 4, 9 Yamada T....Kluve-Beckerman B. (Amyloid 2003)
    5. Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis. (PubMed id 17968686)1, 4, 9 Mavragani C.P....Skopouli F.N. (Amyloid 2007)
    6. SAA1 gene polymorphisms and the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis. (PubMed id 17039310)1, 4, 9 Ajiro J....Gejyo F. (Mod Rheumatol 2006)
    7. Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome. (PubMed id 16011988)1, 4, 9 van der Hilst J.C....Simon A. (Amyloid 2005)
    8. Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study. (PubMed id 19729864)1, 4, 9 Carty C.L....Reiner A.P. (J. Atheroscler. Thromb. 2009)
    9. Genetic risk factors of amyloidogenesis in familial Mediterranean fever. (PubMed id 16118480)1, 4, 9 DelibaA9 A....Yilmaz E. (Am. J. Nephrol. 2005)
    10. A novel polymorphism of human serum amyloid A protein, SAA1 gamma, is characterized by alanines at both residues 52 and 57. (PubMed id 8512321)1, 2, 9 Baba S.... Shirasawa H. (Arch. Biochem. Biophys. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6288 HGNC: 10513 AceView: SAA1 Ensembl:ENSG00000173432 euGenes: HUgn6288
    ECgene: SAA1 H-InvDB: SAA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SAA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SAA1 gene:
    Search GeneIP for patents involving SAA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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