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SAA1 Gene

protein-coding GIFtS: 62

GC11P018244

serum amyloid A1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SAA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC111216 ^²
PIG4 ^¹, ²
SAA ^², ³
TP53I4 ^¹, ²

Descriptions
serum amyloid A1 ^²
tumor protein p53 inducible protein 4 ^²

External Ids
HGNC: 10513¹
Entrez Gene: 6288²
UniProtKB: P02735³
Ensembl: ENSG00000173432⁷

Search outside databases for aliases for SAA1 gene

Previous GC identifers: GC11P019408 GC11P019230 GC11P018326 GC11P018252

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SAA_HUMAN, P02735

Function: Major acute phase reactant. Apolipoprotein of the HDL complex

Gene Wiki entry for SAA1 (Serum_amyloid_A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAA1 gene

Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1

SAA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P018244: (about GC identifiers)

Start:	18,244,348 bp from pter
End:	18,248,102 bp from pter
Size:	3,755 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAA_HUMAN, P02735 (See protein sequence)

Recommended Name: Serum amyloid A protein precursor

Size: 122 amino acids; 13532 Da

Subcellular location: Secreted

Mass spectrometry: Mass=11702; Mass_error=14; Method=MALDI; Range=19-122; Source=PubMed:12973732;

Mass spectrometry: Mass=11682.7; Method=MALDI; Range=19-122; Source=PubMed:12606051;

Mass spectrometry: Mass=11526.5; Method=MALDI; Range=20-122; Source=PubMed:12606051;

Mass spectrometry: Mass=11439.6; Method=MALDI; Range=21-122; Source=PubMed:12606051;

Mass spectrometry: Mass=11363.6; Method=MALDI; Range=20-121; Source=PubMed:12606051;

Mass spectrometry: Mass=11235.6; Method=MALDI; Range=20-120; Source=PubMed:12606051;

Mass spectrometry: Mass=10872.6; Method=MALDI; Range=22-119; Source=PubMed:12606051;

Mass spectrometry: Mass=8337.5; Mass_error=0.8; Method=Electrospray; Range=19-94; Note=With

variants Ala-70, Val-75, Asn-78 and 86-Leu-Thr-87; Source=PubMed:1463770;

Mass spectrometry: Mass=8390.9; Mass_error=0.2; Method=Electrospray; Range=19-94; Note=With variant

Ala-70; Source=PubMed:1463770;

Miscellaneous: Elevated serum SSA protein levels may be associated with lung cancer

Secondary accessions: P02736 P02737 Q16730 Q16834 Q16835 Q16879 Q3KRB3 Q6FG67 Q96QN0 Q9UCK9 Q9UCL0

Post-translational modifications:

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately

24 residues from the C-terminal end¹

REFSEQ proteins (2 alternative transcripts):

NP_000322.2 NP_954630.1

ENSEMBL proteins:

ENSP00000384906 ENSP00000348918

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Serum Amyloid A)
	Human Recombinant Proteins from Abnova (SAA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	7516407 14718574
GO:0034364	high-density lipoprotein particle	IEA	--

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Antibodies for SAA1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SAA1
	R&D Systems Antibodies for SAA1 (Serum Amyloid A1)
	Antibodies from Abcam (Serum Amyloid A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SAA1)
	Novus Biologicals Antibodies for SAA1

Assays for SAA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P02735

ProtoNet protein and cluster: P02735

1 Blocks protein family: IPB000096 Serum amyloid A protein

UniProtKB/Swiss-Prot: SAA_HUMAN, P02735

Similarity: Belongs to the SAA family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000331

Applied Biosystems Silencer® siRNAs for SAA1

Sigma-Aldrich siRNA for SAA1

Sigma-Aldrich shRNA Panels and shRNA for SAA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SAA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000331
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000331
untagged cDNA clones in CMV expression vector (see all 3): BC007022

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000331

UniProtKB/Swiss-Prot: SAA_HUMAN, P02735

Function: Major acute phase reactant. Apolipoprotein of the HDL complex

Induction: Upon cytokine stimulation

Genatlas biochemistry entry for SAA1:

serum amyloid A,1,acute phase reactant,susceptibility gene for juvenile chronic arthritis and AA

amyloidosis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein-coupled receptor binding	IDA	9892621

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAA1 (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling

GeneDecks SAA1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SAA1

5/39 Interacting proteins for SAA1 (ENSP00000348918³) via UniProtKB, MINT, and/or STRING (see all 39 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL6	ENSP00000258743³	STRING (score=.982)
FPR2	ENSP00000340191³	STRING (score=.951)
IL8	ENSP00000306512³	STRING (score=.941)
IL1B	ENSP00000263341³	STRING (score=.918)
CSF3	ENSP00000225474³	STRING (score=.917)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006953	acute-phase response	NAS	9815279
GO:0007204	elevation of cytosolic calcium ion concentration	NAS	7561109
GO:0030168	platelet activation	NAS	1697614
GO:0030593	neutrophil chemotaxis	NAS	12557751
GO:0045785	positive regulation of cell adhesion	NAS	7561109

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAA1
9 Novoseek chemical compound relationships for SAA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colchicine	54.47	4	14978665 (2)
fibrinogen	33.49	9	15515782 (2), 18500463 (2), 1705051 (2), 17103173 (1) (see all 6)
lipid	12.67	13	18356319 (4), 18500463 (1), 15855262 (1), 17849429 (1) (see all 6)
cholesterol	10.56	10	10191288 (5), 19223523 (1), 9109677 (1), 12818406 (1)
endotoxin	6.40	3	9295827 (3)
calcium	4.41	9	9428637 (4), 10608507 (1)
estradiol	0.00	1	15284085 (1)
glucose	0.00	4	15015151 (1), 16571858 (1)
steroid	0.00	2	12410800 (1)

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3 PharmGKB drug compound relationships for SAA1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
colchicine	CO GN	15170927
dexamethasone	FA	12077270 12938239
prednisone	PD	11156544

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000331

Sigma-Aldrich siRNA for SAA1

Sigma-Aldrich shRNA Panels and shRNA for SAA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000331 NM_199161

REFSEQ mRNAs for SAA1 gene (2 alternative transcripts):

NM_000331.3 NM_199161.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000331 NM_199161

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000331
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000331
                                 untagged cDNA clones in CMV expression vector (see all 3): BC007022

Additional cDNA sequence:

BC007022.1 BC105796.1 CR542241.1 M10906.1 M23698.1 X51439.1 X51441.1 X51442.1

X51443.1

9 DOTS entries:

DT.100797172 DT.120759598 DT.100797170 DT.91774129 DT.120759603 DT.75101001 DT.101984537 DT.95149900

DT.91774130

24/304 AceView cDNA sequences (see all 304 ):

AL598974 AL599003 AA344934 T69567 BG545227 M23698 CB999100 CD102084

BG565310 BG563257 BV189929 AA345608 BX490424 CR542241 BG564393 CD512583

NM_199161 BQ691948 BX457214 BM856453 BG568516 BG616738 BX102362 BG533276

highest scoring ESTs for SAA1:

AA829286 AA313033 AA313348 AA319980 AA320417 AA343711 AA343774 AA344933 AA345509 AA345538

Unigene Cluster for SAA1:

Serum amyloid A1

Hs.632144 [show with all ESTs]

Unigene Representative Sequence: BG564669

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000405158 ENST00000356524

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SAA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAA1

¹ / ² / ³

5 probe-sets matching SAA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33272_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	AA829286	1.00	0.70	0.86	1
208607_s_at²	U133-A	2	1.00	0.50	--	--	--	--	--	--	--
214456_x_at²	U133-A	3	0.73	0.48	--	--	--	--	--	--	--
208607_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
214456_x_at²	U133Plus2	3	0.73	0.48	--	--	--	--	--	--	--

GeneDecks SAA1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCGGAGGA

SOURCE GeneReport for Unigene cluster: Hs.632144
Expression variation in blood from EXPOLDB for SAA1
UniProtKB/Swiss-Prot: SAA_HUMAN, P02735
Tissue specificity: Expressed by the liver; secreted in plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for SAA1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAA1¹	--	serum amyloid A1	83.06(n) 81.15(a)	476879 XM_534081.2 XP_534081.1
cow (Bos taurus)	LOC506412¹	--	serum amyloid A-like	84.02(n) 83.47(a)	506412 NM_001075260.1 NP_001068728.1
mouse (Mus musculus)	Saa1⁵ Saa3¹	7 (23.50 cM)⁵	serum amyloid A 1⁵ serum amyloid A 3¹	76.78(n)¹ 71.31(a)¹	20210¹ NM_011315.3¹ NP_035445.1¹ AK136475⁵ BC052495⁵ (see all 9)
zebrafish (Danio rerio)	zgc:103580¹	--	zgc:103580	61.71(n) 57.85(a)	449557 NM_001005599.1 NP_001005599.1

About this table Species with no ortholog for SAA1

ENSEMBL Gene Tree for SAA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for SAA1 gene

SAA3P² SAA2² SAA4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: SAA_HUMAN, P02735

Polymorphism: Both SAA1 and SAA2 have a number of alleles. We use here the nomenclature of

PubMed:1546977. The sequence shown is that of 1-alpha

10/69 NCBI SNPs in SAA1 are shown (see all 69 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 22)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4638289^1,2	A,C,F,H	18242350(+)	`GACCAT/AGAGCT`	2	--	ng5¹		5		EU EA WA NA	477
--	rs11024593^1,2	A,F	18243550(+)	`ATCTCT/GGGATA`	2	--	ng5¹		1		NA	65
--	rs1136743^1,2	C,F	18247435(+)	`GGGTGT/CCTGGG`	2	V/A	mis¹		2		MN NA	254
--	rs1829575^1,2	C,F	18244326(+)	`TCTTCC/GCTCCC`	2	--	ng5¹		1		MN	184
--	rs1136747^1,2	C,F	18247450(+)	`AGAAGT/CGATCA`	2	A/V	mis¹		2		MN NA	78
	rs1869783^1,2	A	18248423(-)	`AAGCCA/TAAGCT`	2	--	ng3¹		0	--	--	--	--
--	rs1059571^1,2	F	18247932(+)	`TGGCAG/AAGACC`	2	R/K	mis¹		2		MN	232
--	rs7103956^1,2	C	18244056(+)	`AGCTGC/TCCTCA`	2	--	ng5¹		0	--	--	--	--
--	rs750949^1,2	A	18243273(-)	`ccttcC/Ttctct`	2	--	ng5¹ trp³		0	--	--	--	--
	rs7114295^1,2	A	18248166(+)	`ATCTAA/GGTGAA`	2	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for SAA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 104750

UniProtKB/Swiss-Prot: SAA_HUMAN, P02735

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in

various tissues of the SAA protein. These deposits are highly insoluble and resistant to

proteolysis; they disrupt tissue structure and compromise function

BOL is from a patient with Waldenstrom macroglobulinemia

JL is from a patient with ankylosing spondylitis

TH is from a patient with juvenile rheumatoid arthritis

10/23 Novoseek disease relationships for SAA1 gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
familial mediterranean fever	84.34	11	16118480 (1), 17103173 (1), 16888022 (1), 1679035 (1) (see all 7)
amyloidosis secondary	81.85	8	16236134 (1), 8268220 (1), 11407685 (1), 14733913 (1) (see all 7)
amyloidosis	81.34	62	14696796 (5), 12762135 (4), 16736418 (3), 11407685 (3) (see all 31)
renal amyloidosis	75.35	6	11017802 (2), 15170927 (2), 16118480 (1), 14696796 (1)
response acute phase	70.60	15	10191288 (3), 16236134 (1), 2070782 (1), 9428637 (1) (see all 8)
inflammation	55.49	24	17103173 (2), 18668591 (2), 10455131 (1), 8091133 (1) (see all 21)
rheumatoid arthritis	55.26	23	17039310 (2), 7780041 (2), 11156544 (2), 9002005 (1) (see all 15)
amyloidosis systemic	48.87	2	10036584 (1), 7504491 (1)
brucellosis	43.57	1	14978665 (1)
atherosclerosis	30.16	3	8657133 (1), 9109677 (1), 10608507 (1)

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3 PharmGKB disease relationships for SAA1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Amyloidosis	CO FA	12077270 12938239 11407685
Arthritis, Rheumatoid	PD	11156544
Familial Mediterranean Fever	CO GN	15170927

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Human Gene Mutation Database: SAA1
Genetic Association Database: SAA1
Human Genome Epidemiology Navigator: SAA1 (13 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/198 PubMed articles for SAA1 gene (see all 198 ):

Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. (PubMed id 15170927)^{1, 3, 6, 7} Bakkaloglu A....Yilmaz E. (2004)
A novel single-nucleotide polymorphism at the 5'-flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. (PubMed id 11407685)^{1, 6, 7} Moriguchi M....Kamatani N. (2001)
Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients. (PubMed id 14696796)^{1, 3, 6} Yilmaz E....Bakkaloglu A. (2003)
The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with familial Mediterranean fever. (PubMed id 12687559)^{1, 3, 6} Gershoni-Baruch R....Livneh A. (2003)
An allele of serum amyloid A1 associated with amyloidosis in both Japanese and Caucasians. (PubMed id 12762135)^{1, 3, 6} Yamada T....Kluve-Beckerman B. (2003)
Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome. (PubMed id 16011988)^{1, 3, 6} van der Hilst J.C....Simon A. (2005)
Genetic risk factors of amyloidogenesis in familial Mediterranean fever. (PubMed id 16118480)^{1, 3, 6} Delibas A....Yilmaz E. (2005)
A novel polymorphism of human serum amyloid A protein, SAA1 gamma, is characterized by alanines at both residues 52 and 57. (PubMed id 8512321)^{1, 3, 4} Baba S.... Shirasawa H. (1993)
Human serum amyloid A protein. Complete amino acid sequence of a new variant. (PubMed id 1546977)^{1, 3, 4} Beach C.M.... de Beer F.C. (1992)
The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells. (PubMed id 1656519)^{1, 3, 4} Betts J.... Woo P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6288	HGNC: 10513	AceView: SAA1	Ensembl:ENSG00000173432	euGenes: HUgn6288
ECgene: SAA1	H-InvDB: SAA1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SAA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SAA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAA1		Antibodies for SAA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SAA1)
	Antibodies (SAA1)
	Chimera RNAi (SAA1)
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SAA1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SAA1

Summaries
for SAA1

Genomic Location
for SAA1

Proteins
for SAA1

Protein Domains/
Families
for SAA1

Gene Function
for SAA1

Pathways & Interactions
for SAA1

Drugs & Compounds
for SAA1

Transcripts
for SAA1

Expression
for SAA1

Orthologs
for SAA1

Paralogs
for SAA1

SNPs/Variants
for SAA1

Disorders & Mutations
for SAA1

Medical News
for SAA1

Publications
for SAA1

Search for SAA1

Genome Databases showing SAA1

Other Databases showing SAA1

Specialized Databases showing SAA1

Licensable Technologies
for SAA1

Services
for SAA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAA1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SAA1

Summariesfor SAA1

Genomic Locationfor SAA1

Proteinsfor SAA1

Protein Domains/Familiesfor SAA1

Gene Functionfor SAA1

Pathways & Interactionsfor SAA1

Drugs & Compoundsfor SAA1

Transcriptsfor SAA1

Expression for SAA1

Orthologsfor SAA1

Paralogsfor SAA1

SNPs/Variantsfor SAA1

Disorders & Mutationsfor SAA1

Medical Newsfor SAA1

Publicationsfor SAA1

Search for SAA1

Genome Databases showing SAA1

Other Databases showing SAA1

Specialized Databases showing SAA1

Licensable Technologiesfor SAA1

Servicesfor SAA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAA1

Summaries
for SAA1

Genomic Location
for SAA1

Proteins
for SAA1

Protein Domains/
Families
for SAA1

Gene Function
for SAA1

Pathways & Interactions
for SAA1

Drugs & Compounds
for SAA1

Transcripts
for SAA1

Expression
for SAA1

Orthologs
for SAA1

Paralogs
for SAA1

SNPs/Variants
for SAA1

Disorders & Mutations
for SAA1

Medical News
for SAA1

Publications
for SAA1

Licensable Technologies
for SAA1

Services
for SAA1