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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SAA1 Gene

protein-coding GIFtS: 60
GCID: GC11P018287

serum amyloid A1

(Previous symbol: SAA)

Explore 49 diseases affiliated with
SAA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serum Amyloid A1¹ ²		SAA2²
SAA¹ ² ³		Serum Amyloid A Protein²
PIG4¹ ²		Serum Amyloid A-1 Protein²
TP53I4¹ ²		Tumor Protein P53 Inducible Protein 4²

External Ids:	HGNC: 10513¹	Entrez Gene: 6288²	Ensembl: ENSG00000173432⁷	OMIM: 104750⁵	UniProtKB: P0DJI8³

Export aliases for SAA1 gene to outside databases

Previous GC identifers: GC11P019408 GC11P019230 GC11P018326 GC11P018252 GC11P018244 GC11P017970

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SAA1:

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase

protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important

role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic

inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This

protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript

variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.(provided by RefSeq, Jun

2012)

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8

Function: Major acute phase reactant. Apolipoprotein of the HDL complex

Gene Wiki entry for SAA1 (Serum amyloid A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SAA1 gene promoter:
AP-2alpha isoform 3 AP-1 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SAA1 promoter sequence

Search SABiosciences Chromatin IP Primers for SAA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1

SAA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAA1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P018287: view genomic region (about GC identifiers)

Start:	18,287,721 bp from pter	End:	18,291,524 bp from pter
Size:	3,804 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8 (See protein sequence)

Recommended Name: Serum amyloid A-1 protein precursor

Size: 122 amino acids; 13532 Da

Subcellular location: Secreted

Mass spectrometry: Mass=11702; Mass_error=14; Method=MALDI; Range=19-122; Source=PubMed:12973732;

Mass spectrometry: Mass=11682.7; Method=MALDI; Range=19-122; Source=PubMed:12606051;

Mass spectrometry: Mass=11526.5; Method=MALDI; Range=20-122; Source=PubMed:12606051;

Mass spectrometry: Mass=11439.6; Method=MALDI; Range=21-122; Source=PubMed:12606051;

Mass spectrometry: Mass=11363.6; Method=MALDI; Range=20-121; Source=PubMed:12606051;

Mass spectrometry: Mass=11235.6; Method=MALDI; Range=20-120; Source=PubMed:12606051;

Mass spectrometry: Mass=10872.6; Method=MALDI; Range=22-119; Source=PubMed:12606051;

Mass spectrometry: Mass=8337.5; Mass_error=0.8; Method=Electrospray; Range=19-94; Note=With variants Ala-70, Val-75,

Asn-78 and 86-Leu-Thr-87; Source=PubMed:1463770;

Mass spectrometry: Mass=8390.9; Mass_error=0.2; Method=Electrospray; Range=19-94; Note=With variant Ala-70;

Source=PubMed:1463770;

Secondary accessions: P02735 P02736 P02737 Q16730 Q16834 Q16835 Q16879 Q3KRB3 Q6FG67 Q96QN0 Q9UCK9

Q9UCL0

Explore the universe of human proteins at neXtProt for SAA1: NX_P0DJI8

Post-translational modifications:

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from

the C-terminal end¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P0DJI8

SAA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000322.2 NP_001171477.1 NP_954630.1

ENSEMBL proteins:

ENSP00000348918 ENSP00000436866 ENSP00000384906

Reactome Protein details: P0DJI8
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	Uscn Proteins for SAA1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	7516407
GO:0034364	high-density lipoprotein particle	IEA	--

SAA1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SAA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SAA1 for domains About GeneDecksing

1 InterPro domain/family:

IPR000096 Serum_amyloid_A

Graphical View of Domain Structure for InterPro Entry P0DJI8

ProtoNet protein and cluster: P0DJI8

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8

Similarity: Belongs to the SAA family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8

Function: Major acute phase reactant. Apolipoprotein of the HDL complex

Induction: Upon cytokine stimulation

Genatlas biochemistry entry for SAA1:

serum amyloid A,1,acute phase reactant,susceptibility gene for juvenile chronic arthritis and AA amyloidosis

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAA1
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAA1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IDA	9892621

SAA1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Saa1/Saa2^Saa1/tm1Itl for SAA1
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Saa1):

homeostasis/metabolism

SAA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Amyloid precursor proteins form ordered fibrils

Amyloid precursor proteins form ordered fibrils

1.00

Amyloids

0.43

Immune System

Immune System

1.00

Innate Immune System

0.46

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for SAA1

	Folate Metabolism
	Selenium Pathway

5/16 Reactome Pathways for SAA1 (see all 16)

	Advanced glycosylation endproduct receptor signaling
	Disease
	Amyloid precursor proteins form ordered fibrils
	Formyl peptide receptors bind formyl peptides and many other ligands
	Signal Transduction

SAA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SAA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for SAA1 (ENSP00000348918⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRRC2A	ENSP00000365175⁴	STRING: ENSP00000365175
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
EIF3F	ENSP00000310040⁴	STRING: ENSP00000310040
FPR1	ENSP00000302707⁴	STRING: ENSP00000302707
PARP1	ENSP00000355759⁴	STRING: ENSP00000355759

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006953	acute-phase response	NAS	9815279
GO:0007204	elevation of cytosolic calcium ion concentration	NAS	7561109
GO:0030168	platelet activation	NAS	1697614
GO:0030593	neutrophil chemotaxis	NAS	12557751
GO:0045785	positive regulation of cell adhesion	NAS	7561109

SAA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SAA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SAA1

2 DrugBank Compounds for SAA1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Serum albumin iodonated	--	9048-49-1	target	--	17016423 10361047 17139284 10903648 9200475
Human Serum Albumin	--	9048-49-1	target	--	17016423 17139284

10/17 Novoseek chemical compound relationships for SAA1 gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tenidap	60.6	3	7818568 (2), 7780040 (1)
colchicine	52.8	4	14978665 (2)
fibrinogen	31.3	9	15515782 (2), 18500463 (2), 1705051 (2), 17103173 (1) (see all 6)
piroxicam	28.9	2	7818568 (2)
lipid	21.9	21	18356319 (4), 19369048 (3), 19850938 (1), 15855262 (1) (see all 9)
dexamethasone	17.8	3	8159722 (1), 8947601 (1)
cholesterol	17.8	12	10191288 (5), 19223523 (1), 19843373 (1), 9109677 (1) (see all 6)
simvastatin	12.3	4	11952885 (2), 12398959 (2)
valine	5.59	2	8512321 (2)
endotoxin	4.21	3	9295827 (3)

Search CenterWatch for drugs/clinical trials and news about SAA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SAA1 gene (3 alternative transcripts):

NM_000331.4 NM_001178006.1 NM_199161.3

Unigene Cluster for SAA1:

Serum amyloid A1

Hs.632144 [show with all ESTs]

Unigene Representative Sequence: BG564669

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356524(uc021qeo.1) ENST00000532858 ENST00000405158(uc021qem.1 uc021qen.1)

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Additional cDNA sequence:

BC007022.1 BC105796.1 CR542241.1 M10906.1 M23698.1 X51439.1 X51443.1

9 DOTS entries:

DT.100797172 DT.120759598 DT.100797170 DT.91774129 DT.120759603 DT.75101001 DT.101984537 DT.95149900

DT.91774130

24/304 AceView cDNA sequences (see all 304):

AA344934 AL599003 AL598974 BG565078 T69567 BX102362 BQ691948 NM_000331

CD102084 BG567754 BG563257 BX457214 CD512583 BG568516 BG545227 AA345608

BG567605 BG566553 BG533276 BG616738 CB999100 BG564393 BG564472 BU676268

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SAA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCGGAGGA

About this image

SAA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Lumbar Vertebral Body

Somite

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

See SAA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAA1

SOURCE GeneReport for Unigene cluster: Hs.632144

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8

Tissue specificity: Expressed by the liver; secreted in plasma

SABiosciences Custom PCR Arrays for SAA1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SAA1 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Saa1^{1 , 5}	serum amyloid A 1^{1, 5}	76.5(n)¹ 72.95(a)¹		7 (30.54 cM)⁵ 20208¹ NM_009117.3¹ NP_033143.1¹ 46740501⁵
zebrafish (Danio rerio)	Actinopterygii	saa¹	serum amyloid A	61.71(n) 57.85(a)		449557 NM_001005599.1 NP_001005599.1

ENSEMBL Gene Tree for SAA1 (if available)
TreeFam Gene Tree for SAA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SAA1 gene

SAA2² SAA4²

3 SIMAP similar genes for SAA1 using alignment to 3 protein entries: SAA1_HUMAN (see all proteins):

HuSAA1g SAA2 SAA4

SAA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8

Polymorphism: At least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3

(SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2). We use here the revised

nomenclature described in PubMed:10211414. The sequence shown is that of SAA1.1

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1136743^1,2	C,F,H,	pathogenic	18290859(+)	`GGGTGT/CCTGGG`	6	/A /V	mis¹		7		MN NA WA CSA	266
rs79681911^1,2	C,F,	pathogenic	18291302(+)	`CCATGG/ATGCGG`	6	/D /G	mis¹		1		EA	120
rs186361956^1,2		--	18285887(+)	`TTCATG/TCTCTT`	3	--	us2k¹		0	--	--	--	--
rs11024592^1,2	C,F,	--	18286093(+)	`ACTCAG/AACATA`	3	--	us2k¹		9		NA WA CSA EA	368
rs2403276^1,2	C,A,	--	18286113(-)	`GGACTA/GCAGTT`	3	--	us2k¹		11		NA WA CSA EA	372
rs115492543^1,2		--	18286134(+)	`GGAGGC/TTGAGA`	3	--	us2k¹		0	--	--	--	--
rs34844715^1,2	C,F,	--	18286206(+)	`CTCCAG/ACTCAG`	3	--	us2k¹		5		NA WA	128
rs2896520^1,2	C,	--	18286263(-)	`cctccT/Cctccc`	3	--	us2k¹ tfbs³ trp³		7		NA WA CSA	246
rs146869455^1,2		--	18286350(+)	`GGAGG-/GGAGGAGA`	3	--	us2k¹		0	--	--	--	--
rs61882742^1,2	C,	--	18286402(+)	`GACTTA/CCTGTT`	3	--	us2k¹		6		NA WA EA	364

HapMap Linkage Disequilibrium report for SAA1 (18287721 - 18291524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SAA1: --
Human Gene Mutation Database (HGMD): SAA1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SAA1 for disorders About GeneDecksing

OMIM gene information: 104750 OMIM disorders: --

UniProtKB/Swiss-Prot: SAA1_HUMAN, P0DJI8

Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of

the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and

compromise function

Note=Elevated serum SAA1 protein levels may be associated with lung cancer

20/49 diseases for SAA1 (see all 49): About MalaCards

rheumatoid arthritis hyper-igd syndrome familial cold autoinflammatory syndrome familial mediterranean fever

arthritis atherosclerosis splenic artery aneurysm myocardial infarction

acute myocardial infarction crohn's disease cholesterol amyloidosis

periodic fever sleep apnea amyloidosis, secondary polycystic ovary syndrome

ankylosing spondylitis insulin resistance brucellosis alzheimer's disease

6 diseases from the University of Copenhagen DISEASES database for SAA1:

Amyloidosis Familial Mediterranean fever Bone marrow disease Splenic artery aneurysm

Rheumatoid arthritis Anemia

10/23 Novoseek disease relationships for SAA1 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
familial mediterranean fever	83.1	11	16118480 (1), 17103173 (1), 16888022 (1), 1679035 (1) (see all 7)
amyloidosis secondary	80.8	8	16236134 (1), 8268220 (1), 11407685 (1), 14733913 (1) (see all 7)
amyloidosis	80.1	62	14696796 (5), 12762135 (4), 16736418 (3), 11407685 (3) (see all 31)
renal amyloidosis	74.1	6	11017802 (2), 15170927 (2), 16118480 (1), 14696796 (1)
response acute phase	72.8	15	10191288 (3), 16236134 (1), 2070782 (1), 9428637 (1) (see all 8)
rheumatoid arthritis	56.8	23	17039310 (2), 7780041 (2), 11156544 (2), 9002005 (1) (see all 15)
inflammation	56	28	17103173 (2), 18668591 (2), 19843373 (2), 10455131 (1) (see all 24)
amyloidosis systemic	46.9	2	10036584 (1), 7504491 (1)
brucellosis	41.2	1	14978665 (1)
atherosclerosis	38.7	5	8657133 (1), 19843373 (1), 9109677 (1), 10608507 (1) (see all 5)

Genetic Association Database (GAD): SAA1
Human Genome Epidemiology (HuGE) Navigator: SAA1 (23 documents)

Export disorders for SAA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SAA1 gene, integrated from 9 sources (see all 271):
(articles sorted by number of sources associating them with SAA1)

Utopia: connect your pdf to the dynamic
world of online information

Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. (PubMed id 15170927)^{1, 4, 9} Bakkaloglu A....Yilmaz E. (2004)
Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients. (PubMed id 14696796)^{1, 4, 9} Yilmaz E....Bakkaloglu A. (2003)
The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with familial Mediterranean fever. (PubMed id 12687559)^{1, 4, 9} Gershoni-Baruch R....Livneh A. (2003)
An allele of serum amyloid A1 associated with amyloidosis in both Japanese and Caucasians. (PubMed id 12762135)^{1, 4, 9} Yamada T....Kluve-Beckerman B. (2003)
Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome. (PubMed id 16011988)^{1, 4, 9} van der Hilst J.C....Simon A. (2005)
Genetic risk factors of amyloidogenesis in familial Mediterranean fever. (PubMed id 16118480)^{1, 4, 9} Delibas A....Yilmaz E. (2005)
A novel polymorphism of human serum amyloid A protein, SAA1 gamma, is characterized by alanines at both residues 52 and 57. (PubMed id 8512321)^{1, 2, 9} Baba S.... Shirasawa H. (1993)
Human serum amyloid A protein. Complete amino acid sequence of a new variant. (PubMed id 1546977)^{1, 2, 9} Beach C.M.... de Beer F.C. (1992)
The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells. (PubMed id 1656519)^{1, 2, 9} Betts J.... Woo P. (1991)
The frequencies of the serum amyloid A2 alleles in healthy (Turkish, Azerbaijan and Kazakh) populations. (PubMed id 16152805)^{1, 4, 9} Tastan H....Tuzun A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6288	HGNC: 10513	AceView: SAA1	Ensembl:ENSG00000173432	euGenes: HUgn6288
ECgene: SAA1	H-InvDB: SAA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SAA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SAA1 gene
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Patent Information for SAA1 gene:
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GeneCards and IP:
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