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Aliases for S1PR5 Gene

Aliases for S1PR5 Gene

  • Sphingosine-1-Phosphate Receptor 5 2 3
  • EDG8 3 4 6
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 8 2 3
  • Endothelial Differentiation G-Protein-Coupled Receptor 8 3 4
  • Sphingosine 1-Phosphate Receptor Edg-8 3 4
  • S1P Receptor Edg-8 3 4
  • S1P Receptor 5 3 4
  • S1P5 3 4
  • Sphingosine 1-Phosphate Receptor EDG8 3
  • Sphingosine 1-Phosphate Receptor 5 3
  • SPPR-1 3
  • SPPR-2 3
  • Edg-8 3

External Ids for S1PR5 Gene

Previous Symbols for S1PR5 Gene

  • EDG8

Summaries for S1PR5 Gene

Entrez Gene Summary for S1PR5 Gene

  • The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

GeneCards Summary for S1PR5 Gene

S1PR5 (Sphingosine-1-Phosphate Receptor 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR5 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Tocris Summary for S1PR5 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR5 Gene

Genomics for S1PR5 Gene

Genomic Location for S1PR5 Gene

Start:
10,512,742 bp from pter
End:
10,517,992 bp from pter
Size:
5,251 bases
Orientation:
Minus strand

Genomic View for S1PR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S1PR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR5 Gene

Regulatory Elements for S1PR5 Gene

Proteins for S1PR5 Gene

  • Protein details for S1PR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H228-S1PR5_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 5
    Protein Accession:
    Q9H228
    Secondary Accessions:
    • Q6NW11

    Protein attributes for S1PR5 Gene

    Size:
    398 amino acids
    Molecular mass:
    41775 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for S1PR5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for S1PR5 Gene

Proteomics data for S1PR5 Gene at MOPED

Post-translational modifications for S1PR5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn20

Other Protein References for S1PR5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR5 Gene

Domains for S1PR5 Gene

Gene Families for S1PR5 Gene

HGNC:
  • S1PR :GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate
IUPHAR :

UniProtKB/Swiss-Prot:

S1PR5_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9H228
genes like me logo Genes that share domains with S1PR5: view

Function for S1PR5 Gene

Molecular function for S1PR5 Gene

UniProtKB/Swiss-Prot Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Gene Ontology (GO) - Molecular Function for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with S1PR5: view
genes like me logo Genes that share phenotypes with S1PR5: view

miRNA for S1PR5 Gene

miRTarBase miRNAs that target S1PR5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for S1PR5 Gene

Localization for S1PR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR5 Gene COMPARTMENTS Subcellular localization image for S1PR5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with S1PR5: view

Pathways for S1PR5 Gene

genes like me logo Genes that share pathways with S1PR5: view

Gene Ontology (GO) - Biological Process for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0045664 regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with S1PR5: view

Compounds for S1PR5 Gene

(5) Tocris Compounds for S1PR5 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist [1094042-01-9]
JTE 013 S1P2 receptor antagonist [547756-93-4]
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 [26993-30-6]
VPC 23019 S1P1 and S1P3 antagonist [449173-19-7]
W146 Potent and selective S1P1 receptor antagonist [909725-62-8]

(1) HMDB Compounds for S1PR5 Gene

Compound Synonyms Cas Number PubMed IDs
Sphingosine
  • (-)-D-erythro-Sphingosine
123-78-4

(1) Drugbank Compounds for S1PR5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Fingolimod
  • 2-amino-2-(2-(4-octylphenyl)ethyl]propan-1,3-diol hydrochloride
162359-55-9 target modulator

(5) IUPHAR Ligand for S1PR5 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
AFD(R) Agonist Agonist 8.4
FTY720-phosphate Agonist Agonist 8.4
VPC44116 Antagonist Antagonist 6.52
compound 26 [PMID:16190743] Agonist Agonist 4.9

(1) Novoseek inferred chemical compound relationships for S1PR5 Gene

Compound -log(P) Hits PubMed IDs
sphingosine 78.3 2
genes like me logo Genes that share compounds with S1PR5: view

Transcripts for S1PR5 Gene

Unigene Clusters for S1PR5 Gene

Sphingosine-1-phosphate receptor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for S1PR5 Gene

GeneLoc Exon Structure for
S1PR5
ECgene alternative splicing isoforms for
S1PR5

Expression for S1PR5 Gene

mRNA expression in normal human tissues for S1PR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR5 Gene

This gene is overexpressed in Whole Blood (8.9), Brain - Spinal cord (cervical c-1) (7.2), and Brain - Substantia nigra (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for S1PR5 Gene

SOURCE GeneReport for Unigene cluster for S1PR5 Gene Hs.501561

mRNA Expression by UniProt/SwissProt for S1PR5 Gene

Q9H228-S1PR5_HUMAN
Tissue specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.
genes like me logo Genes that share expressions with S1PR5: view

Orthologs for S1PR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR5 36
  • 99.32 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia S1PR5 36
  • 84.84 (n)
  • 85.18 (a)
S1PR5 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR5 36
  • 85.68 (n)
  • 85.68 (a)
S1PR5 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr5 36
  • 79.93 (n)
  • 86.99 (a)
S1pr5 16
S1pr5 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S1PR5 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr5 36
  • 79.7 (n)
  • 86.8 (a)
lizard
(Anolis carolinensis)
Reptilia S1PR5 37
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii s1pr5a 37
  • 47 (a)
OneToMany
s1pr5b 36
  • 62.02 (n)
  • 56.06 (a)
s1pr5b 37
  • 50 (a)
OneToMany
Species with no ortholog for S1PR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR5 Gene

ENSEMBL:
Gene Tree for S1PR5 (if available)
TreeFam:
Gene Tree for S1PR5 (if available)

Paralogs for S1PR5 Gene

Selected SIMAP similar genes for S1PR5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with S1PR5: view

Variants for S1PR5 Gene

Sequence variations from dbSNP and Humsavar for S1PR5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892042 -- 10,515,885(-) GCACA(A/G)TCAAT intron-variant
rs6511701 -- 10,514,391(+) CAGAT(A/C)GCGGC synonymous-codon, reference
rs7256518 -- 10,515,699(+) gaggc(A/G)ggagg intron-variant
rs7260034 -- 10,512,327(+) CAAAC(C/T)CCCAG downstream-variant-500B
rs10402752 -- 10,516,093(+) AAAAA(C/T)ACATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S1PR5 Gene

Variant ID Type Subtype PubMed ID
dgv3725n71 CNV Loss 21882294
nsv833744 CNV Loss 17160897
nsv911042 CNV Loss 21882294
dgv3727n71 CNV Loss 21882294

Relevant External Links for S1PR5 Gene

HapMap Linkage Disequilibrium report
S1PR5

Disorders for S1PR5 Gene

Relevant External Links for S1PR5

Genetic Association Database (GAD)
S1PR5
Human Genome Epidemiology (HuGE) Navigator
S1PR5
genes like me logo Genes that share disorders with S1PR5: view

No data available for UniProtKB/Swiss-Prot for S1PR5 Gene

Publications for S1PR5 Gene

  1. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. (PMID: 11705398) Im D.-S. … Lynch K.R. (Biochemistry 2001) 3 4 23
  2. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. (PMID: 12427546) Kothapalli R. … Loughran T.P. Jr. (Biochim. Biophys. Acta 2002) 3 4 23
  3. Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. (PMID: 15530552) Ulfig N. … Briese M. (Acta Histochem. 2004) 3 4 23
  4. The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. (PMID: 19211033) Gillies L. … Pyne S. (Cell. Signal. 2009) 3 23
  5. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4

Products for S1PR5 Gene

Sources for S1PR5 Gene

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