Aliases for S1PR5 Gene
External Ids for S1PR5 Gene
Previous HGNC Symbols for S1PR5 Gene
Previous GeneCards Identifiers for S1PR5 Gene
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
GeneCards Summary for S1PR5 Gene
S1PR5 (Sphingosine-1-Phosphate Receptor 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for S1PR5 Gene
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.