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S1PR5 Gene

protein-coding   GIFtS: 65
GCID: GC19M010626

Sphingosine-1-Phosphate Receptor 5

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Receptor 51 2     S1P Receptor Edg-82 3
EDG81 2 3 5     Edg-82
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 81 2     SPPR-12
Endothelial Differentiation G-Protein-Coupled Receptor 82 3     SPPR-22
Sphingosine 1-Phosphate Receptor Edg-82 3     Sphingosine 1-Phosphate Receptor 52
S1P52 3     Sphingosine 1-Phosphate Receptor EDG82
S1P Receptor 52 3     

External Ids:    HGNC: 142991   Entrez Gene: 536372   Ensembl: ENSG000001807397   OMIM: 6051465   UniProtKB: Q9H2283   

Export aliases for S1PR5 gene to outside databases

Previous GC identifers: GC19M010485 GC19M010201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S1PR5 Gene:
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite
retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand.
S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G
protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors;
others (e.g., EDG2; MIM 602282) are LPA receptors.(supplied by OMIM, Mar 2008)

GeneCards Summary for S1PR5 Gene:
S1PR5 (sphingosine-1-phosphate receptor 5) is a protein-coding gene. Diseases associated with S1PR5 include hematopoietic stem cell transplantation, and endotheliitis. GO annotations related to this gene include sphingosine-1-phosphate receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha
and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of
radial glial cells into astrocytes and may affect proliferative activity of these cells

summary for S1PR5 Gene:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the S1PR5 gene promoter:
         USF1   MIF-1   GATA-2   Arnt   Egr-4   Max   USF-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS1PR5 promoter sequence
   Search Chromatin IP Primers for S1PR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S1PR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

S1PR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010626:  view genomic region     (about GC identifiers)

Start:
10,623,418 bp from pter      End:
10,628,668 bp from pter
Size:
5,251 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 5  
Size: 398 amino acids; 41775 Da
Developmental stage: At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical
plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some
of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain
immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial
fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found
Secondary accessions: Q6NW11
Alternative splicing: 2 isoforms:  Q9H228-1   Q9H228-2   

Explore the universe of human proteins at neXtProt for S1PR5: NX_Q9H228

Explore proteomics data for S1PR5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn20
  • Modification sites at PhosphoSitePlus

  • See S1PR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159687.1  NP_110387.1  

    ENSEMBL proteins: 
     ENSP00000328472   ENSP00000416915   ENSP00000464884  
    Reactome Protein details: Q9H228

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    S1PR: GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

    IUPHAR Guide to PHARMACOLOGY protein family classification: S1P5 receptor
    Lysophospholipid (S1P) receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005386 EDG8_S1P_rcpt
     IPR004061 S1P_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H228

    ProtoNet protein and cluster: Q9H228

    2 Blocks protein domains:
    IPB004061 Sphingosine 1-phosphate receptor family signature
    IPB005386 EDG-8 sphingosine 1-phosphate receptor signature


    UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228
    Similarity: Belongs to the G-protein coupled receptor 1 family


    S1PR5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S1PR5_HUMAN, Q9H228
    Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
    that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha
    and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of
    radial glial cells into astrocytes and may affect proliferative activity of these cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0038036sphingosine-1-phosphate receptor activity IEA--
         
    S1PR5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for S1PR5:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S1pr5):
     hematopoietic system  immune system  nervous system 

    S1PR5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S1PR5
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    hsa-miR-3685 hsa-miR-155* hsa-miR-3918 hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidS1PR5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S1PR5_HUMAN, Q9H228: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    S1PR5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S1PR5 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3S1P3 pathway
    Sphingosine 1-phosphate (S1P) pathway0.40
    S1P5 pathway0.00
    S1P4 pathway0.36
    4Signal Transduction of S1P Receptor
    Signal Transduction of S1P Receptor
    5Lysosphingolipid and LPA receptors
    Lysosphingolipid and LPA receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for S1PR5
        Ceramide Pathway
    S-1P Stimulated Signaling
    eNOS Signaling
    Human Embryonic Stem Cell Pluripotency

    4 BioSystems Pathways for S1PR5
        Signal Transduction of S1P Receptor
    Sphingosine 1-phosphate (S1P) pathway
    S1P5 pathway
    S1P4 pathway

    2 Reactome Pathways for S1PR5
        Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for S1PR5):
        Neuroactive ligand-receptor interaction


    S1PR5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including S1PR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for S1PR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for S1PR5 (Q9H2283 ENSP000003284724) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    SGPP1Q9BX953, ENSP000002472254I2D: score=1 STRING: ENSP00000247225
    GNA12Q031133, ENSP000002753644I2D: score=1 STRING: ENSP00000275364
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0045664regulation of neuron differentiation IEA--

    S1PR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for S1PR5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    CYM 5442 hydrochlorideSelective S1P1 receptor agonist[1094042-01-9]
    JTE 013S1P2 receptor antagonist[547756-93-4]
    VPC 23019S1P1 and S1P3 antagonist[449173-19-7]
    W146Potent and selective S1P1 receptor antagonist[909725-62-8]

    1 HMDB Compound for S1PR5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--

    1 DrugBank Compound for S1PR5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fingolimod2-amino-2-(2-(4-octylphenyl)ethyl]propan-1,3-diol hydrochloride (see all 6)162359-55-9targetmodulator23579456 23579459

    5 IUPHAR Ligands for S1PR5 (S1P5 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    compound 26 [PMID:16190743]
    AgonistAgonist916190743
    AFD(R)
    AgonistAgonist8.911967257
    FTY720-phosphate
    AgonistAgonist8.211967257
    VPC44116
    AgonistPartial agonist7.517113298
    sphingosine 1-phosphate
    AgonistAgonist7.3611705398 11967257

    1 Novoseek inferred chemical compound relationship for S1PR5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 78.3 7 19211033 (2)



    S1PR5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for S1PR5 gene (2 alternative transcripts): 
    NM_001166215.1  NM_030760.4  

    Unigene Cluster for S1PR5:

    Sphingosine-1-phosphate receptor 5
    Hs.501561  [show with all ESTs]
    Unigene Representative Sequence: NM_001166215
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333430(uc002mot.2) ENST00000439028(uc002mou.2) ENST00000590601

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    SwitchGear 3'UTR luciferase reporter plasmidS1PR5 3' UTR sequence
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    Additional mRNA sequence: 

    AF088014.1 AF331840.1 AF331841.1 AF331842.1 AK074661.1 AK094880.1 BC034703.1 BC067781.1 

    7 DOTS entries:

    DT.101968559  DT.405571  DT.97839596  DT.100022816  DT.97839597  DT.121453900  DT.100728241 

    Selected AceView cDNA sequences (see all 49):

    BX282038 BX349015 NM_030760 BE646254 CB049904 AF331842 BF446252 AF088014 
    AF331841 CR619597 BI820384 BX339822 AF331840 AI439969 AI814092 CF147802 
    AI635837 AK094880 CA432481 AK074661 BU620561 BX339823 AI823789 N47089 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for S1PR5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:        -     -     -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for S1PR5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S1PR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGTTGAA
    S1PR5 Expression
    About this image


    S1PR5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Epidermis (Integumentary System)
    S1PR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S1PR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501561

    UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228
    Tissue specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly
    white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level
    signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is
    predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood
    leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including S1PR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S1pr51 , 5 sphingosine-1-phosphate receptor 51, 5 79.93(n)1
    86.99(a)1
      9 (7.75 cM)5
    942261  NM_053190.21  NP_444420.11 
     212429125 
    lizard
    (Anolis carolinensis)
    Reptilia S1PR56
    sphingosine-1-phosphate receptor 5
    52(a)
    1 ↔ 1
    2(80239345-80240472)
    zebrafish
    (Danio rerio)
    Actinopterygii s1pr5b1 sphingosine-1-phosphate receptor 5b 62.02(n)
    56.06(a)
      780835  NM_001079656.1  NP_001073124.1 


    ENSEMBL Gene Tree for S1PR5 (if available)
    TreeFam Gene Tree for S1PR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S1PR5 gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR32  S1PR22  LPAR12  
    MC1R2  MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  
    LPAR32  
    11 SIMAP similar genes for S1PR5 using alignment to 3 protein entries:     S1PR5_HUMAN (see all proteins):
    EDG1    S1PR3    S1PR1    S1PR2    S1PR4    EDG2
    LPAR1    LPAR3    LPAR2    GPR12    GPR3

    S1PR5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S1PR5 (see all 173)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460394971,2
    C--10622985(+) TGTTGA/CCCAGG 2 -- int10--------
    rs72600341,2
    C,F,A--10623003(+) CAAACT/CCCCAG 2 -- int13Minor allele frequency- C:0.07WA NA 240
    rs1395618211,2
    C--10623013(+) GCCTCA/TATCGA 2 -- int10--------
    rs1881803041,2
    --10623144(+) AGGCTG/TGAGTG 2 -- int10--------
    rs1809326521,2
    --10623156(+) AGCTCC/TTTGCA 2 -- int10--------
    rs1856156501,2
    --10623296(+) AAACTA/GGTCTC 2 -- int10--------
    rs1497236981,2
    --10623371(+) GTCACA/GGCACC 2 -- int10--------
    rs1457467041,2
    --10623374(+) ACGGCA/GCCCAG 2 -- int10--------
    rs1485348361,2
    C--10623381(+) CCAGCC/GTATTA 2 -- int10--------
    rs711620831,2
    C,F--10623603(-) TTTCT-/T/T   
      TCTTTC
    TTTTT
    4 -- ut312NA 4

    HapMap Linkage Disequilibrium report for S1PR5 (10623418 - 10628668 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for S1PR5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833744CNV Loss17160897
    nsv911042CNV Loss21882294
    dgv3727n71CNV Loss21882294
    dgv3725n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S1PR5
    DNA2.0 Custom Variant and Variant Library Synthesis for S1PR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605146    OMIM disorders: --

    9 diseases for S1PR5:    
    About MalaCards
    hematopoietic stem cell transplantation    endotheliitis    pertussis    graft versus host disease
    obesity    prostate cancer    prostatitis    neuronitis
    leukemia


    S1PR5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): S1PR5
    Human Genome Epidemiology (HuGE) Navigator: S1PR5 (1 document)

    Export disorders for S1PR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S1PR5 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with S1PR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. (PubMed id 11705398)1, 2, 9 Im D.-S.... Lynch K.R. (Biochemistry 2001)
    2. Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. (PubMed id 15530552)1, 2, 9 Ulfig N. and Briese M. (Acta Histochem. 2004)
    3. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. (PubMed id 12427546)1, 2, 9 Kothapalli R.... Loughran T.P. Jr. (Biochim. Biophys. Acta 2002)
    4. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PubMed id 20950786)1, 4 Glessner J.T....Grant S.F. (Am. J. Hum. Genet. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    9. Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. (PubMed id 12234605)1, 2 Niedernberg A.... Kostenis E. (Biochem. Pharmacol. 2002)
    10. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. (PubMed id 10799507)1, 3 Im D.S....Lynch K.R. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53637 HGNC: 14299 AceView: EDG8 Ensembl:ENSG00000180739 euGenes: HUgn53637
    ECgene: S1PR5 Kegg: 53637 H-InvDB: S1PR5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S1PR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S1PR5 gene:
    Search GeneIP for patents involving S1PR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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