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S1PR4 Gene

protein-coding   GIFtS: 58
GCID: GC19P003178

Sphingosine-1-Phosphate Receptor 4

(Previous names: endothelial differentiation, G-protein-coupled receptor...)
(Previous symbol: EDG6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Receptor 41 2     S1P Receptor 42 3
EDG61 2 3 5     S1P Receptor Edg-62 3
S1P42 3 5     LPC12
Endothelial Differentiation, G-Protein-Coupled Receptor 61 2     SLP42
Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled
Receptor, 61 2
     Endothelial Differentiation, G Protein Coupled Receptor 62
Endothelial Differentiation G-Protein Coupled Receptor 62 3     Sphingosine 1-Phosphate Receptor 42
Sphingosine 1-Phosphate Receptor Edg-62 3     

External Ids:    HGNC: 31701   Entrez Gene: 86982   Ensembl: ENSG000001259107   OMIM: 6037515   UniProtKB: O959773   

Export aliases for S1PR4 gene to outside databases

Previous GC identifers: GC19P003130 GC19P002945


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S1PR4 Gene:
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG
receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many
different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.
(provided by RefSeq, Jul 2008)

GeneCards Summary for S1PR4 Gene:
S1PR4 (sphingosine-1-phosphate receptor 4) is a protein-coding gene. Diseases associated with S1PR4 include endotheliitis, and pertussis. GO annotations related to this gene include sphingosine-1-phosphate receptor activity and G-protein coupled receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: S1PR4_HUMAN, O95977
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration
processes that are specific for lymphocytes

summary for S1PR4 Gene:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the S1PR4 gene promoter:
         GR   Pax-5   NRSF form 1   HSF1 (long)   NRSF form 2   C/EBPalpha   PPAR-alpha   HEN1   HOXA5   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS1PR4 promoter sequence
   Search Chromatin IP Primers for S1PR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S1PR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

S1PR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003178:  view genomic region     (about GC identifiers)

Start:
3,172,344 bp from pter      End:
3,180,330 bp from pter
Size:
7,987 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S1PR4_HUMAN, O95977 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 4  
Size: 384 amino acids; 41623 Da
1 PDB 3D structure from and Proteopedia for S1PR4:
2DCO (3D)    
Secondary accessions: D6W612

Explore the universe of human proteins at neXtProt for S1PR4: NX_O95977

Explore proteomics data for S1PR4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn30
  • Modification sites at PhosphoSitePlus

  • See S1PR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003766.1  
    ENSEMBL proteins: 
     ENSP00000246115  
    Reactome Protein details: O95977

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    S1PR: GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

    IUPHAR Guide to PHARMACOLOGY protein family classification: S1P4 receptor
    Lysophospholipid (S1P) receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004061 S1P_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR004064 EDG6_rcpt

    Graphical View of Domain Structure for InterPro Entry O95977

    ProtoNet protein and cluster: O95977

    2 Blocks protein domains:
    IPB004061 Sphingosine 1-phosphate receptor family signature
    IPB004064 EDG-6 sphingosine 1-phosphate receptor signature


    UniProtKB/Swiss-Prot: S1PR4_HUMAN, O95977
    Similarity: Belongs to the G-protein coupled receptor 1 family


    S1PR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S1PR4_HUMAN, O95977
    Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
    that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration
    processes that are specific for lymphocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10679247
    GO:0008289lipid binding TAS10679247
    GO:0038036sphingosine-1-phosphate receptor activity IEA--
         
    S1PR4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for S1PR4:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for S1pr4):
     hematopoietic system  mortality/aging  nervous system 

    S1PR4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out S1pr4tm1Lipp for S1PR4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S1PR4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S1PR4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S1PR4_HUMAN, O95977: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9790765
    GO:0016021integral component of membrane ----

    S1PR4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S1PR4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3S1P3 pathway
    Sphingosine 1-phosphate (S1P) pathway0.40
    S1P4 pathway0.36
    4Eicosanoid ligand-binding receptors
    Small Ligand GPCRs0.31
    5Lysosphingolipid and LPA receptors
    Lysosphingolipid and LPA receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for S1PR4
        Ceramide Pathway
    S-1P Stimulated Signaling
    eNOS Signaling
    Human Embryonic Stem Cell Pluripotency

    3 BioSystems Pathways for S1PR4
        Sphingosine 1-phosphate (S1P) pathway
    S1P4 pathway
    Small Ligand GPCRs

    2 Reactome Pathways for S1PR4
        Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for S1PR4):
        FoxO signaling pathway
    Neuroactive ligand-receptor interaction


    S1PR4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including S1PR4: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for S1PR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for S1PR4 (O959773 ENSP000002461154) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIVA1O153043, ENSP000003292134I2D: score=1 STRING: ENSP00000329213
    GNA12Q031133, ENSP000002753644I2D: score=3 STRING: ENSP00000275364
    GNA13Q143443, ENSP000004007174I2D: score=2 STRING: ENSP00000400717
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    KIAA1279Q96EK53I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9790765
    GO:0007186G-protein coupled receptor signaling pathway TAS9790765
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007202activation of phospholipase C activity TAS10679247
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS10679247

    S1PR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for S1PR4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    CYM 5442 hydrochlorideSelective S1P1 receptor agonist[1094042-01-9]
    JTE 013S1P2 receptor antagonist[547756-93-4]
    VPC 23019S1P1 and S1P3 antagonist[449173-19-7]
    W146Potent and selective S1P1 receptor antagonist[909725-62-8]

    1 HMDB Compound for S1PR4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--

    5 IUPHAR Ligands for S1PR4 (S1P4 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    phytosphingosine 1-phosphate
    AgonistAgonist8.812270137
    AFD(R)
    AgonistAgonist8.411967257
    dihydrosp?aehingosine?ae-1-phosph?aeate
    AgonistAgonist812270137
    sphingosine 1-phosphate
    AgonistAgonist7.912270137
    compound 26 [PMID:16190743]
    AgonistAgonist7.1516190743

    1 Novoseek inferred chemical compound relationship for S1PR4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 87.2 1 10753843 (1)



    S1PR4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for S1PR4 gene: 
    NM_003775.3  

    Unigene Cluster for S1PR4:

    Sphingosine-1-phosphate receptor 4
    Hs.662006  [show with all ESTs]
    Unigene Representative Sequence: NM_003775
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591346 ENST00000246115(uc002lxg.3)
    miRNA
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    Additional mRNA sequence: 

    AJ000479.1 BC014970.1 FJ200495.1 

    1 DOTS entry:

    DT.75163397 

    Selected AceView cDNA sequences (see all 49):

    BG744043 AW451146 AL560216 BI907726 CR590635 CA314158 BI906435 BC014970 
    BI908610 CR610253 AA353166 CR608611 BF974516 BX349251 BI824604 BI834290 
    BI910894 NM_003775 BF663028 BI906532 BM922943 CB529025 BI909157 AL560608 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S1PR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGGCAAC
    S1PR4 Expression
    About this image

    S1PR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S1PR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.662006

    UniProtKB/Swiss-Prot: S1PR4_HUMAN, O95977
    Tissue specificity: Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in
    lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung.
    Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and
    lung

        Pathway & Disease-focused RT2 Profiler PCR Array including S1PR4: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S1pr41 , 5 sphingosine-1-phosphate receptor 41, 5 81.17(n)1
    83.29(a)1
      10 (39.72 cM)5
    136111  NM_010102.21  NP_034232.11 
     814977455 
    chicken
    (Gallus gallus)
    Aves S1PR41 sphingosine-1-phosphate receptor 4 65.22(n)
    56.52(a)
      430495  XM_004948726.1  XP_004948783.1 
    lizard
    (Anolis carolinensis)
    Reptilia S1PR46
    sphingosine-1-phosphate receptor 4
    50(a)
    1 ↔ 1
    GL343717.1(190415-191578)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia s1pr41 sphingosine-1-phosphate receptor 4 53.72(n)
    52.07(a)
      100490772  XM_002936330.2  XP_002936376.1 
    zebrafish
    (Danio rerio)
    Actinopterygii s1pr41 sphingosine-1-phosphate receptor 4 55.27(n)
    49(a)
      402857  NM_001118891.1  NP_001112363.1 


    ENSEMBL Gene Tree for S1PR4 (if available)
    TreeFam Gene Tree for S1PR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S1PR4 gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR32  S1PR22  LPAR12  
    MC1R2  MC3R2  MC5R2  MC2R2  GPR32  MC4R2  GPR62  LPAR32  
    S1PR52  
    9 SIMAP similar genes for S1PR4 using alignment to 1 protein entry:     S1PR4_HUMAN:
    EDG1    S1PR1    S1PR2    S1PR3    LPAR3    S1PR5
    LPAR2    LPAR1    EDG2

    S1PR4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S1PR4 (see all 232)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464652011,2
    Cuntested13179433(+) CCGGCA/GTCCTG 2 I V mis10--------
    rs1503621001,2
    --3176748(+) TGGAGA/GGCAGA 1 -- us2k10--------
    rs1379232761,2
    C--3176770(+) CCATCC/TGTGAC 1 -- us2k10--------
    rs791518441,2
    C--3176802(+) ATGCCC/TCAGAC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs104067661,2
    C,A--3176858(+) TGAGCA/CTCCCC 1 -- us2k10--------
    rs104067681,2
    A--3176864(+) TCCCCA/CCTCAG 1 -- us2k10--------
    rs104124221,2
    A--3176873(+) AGACCC/TCAGGG 1 -- us2k10--------
    rs104124241,2
    A--3176879(+) CAGGGC/TAGGGC 1 -- us2k10--------
    rs104069731,2
    A--3176920(+) GCCTCA/GCCTCT 1 -- us2k10--------
    rs104069761,2
    A--3176932(+) CCCTCA/GGACCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for S1PR4 (3172344 - 3180330 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for S1PR4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509716CNV Insertion20534489
    nsv910714CNV Loss21882294
    dgv3648n71CNV Loss21882294
    nsv910697CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S1PR4
    DNA2.0 Custom Variant and Variant Library Synthesis for S1PR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603751    OMIM disorders: --

    3 diseases for S1PR4:    About MalaCards
    endotheliitis    pertussis    breast cancer


    S1PR4 for disorders           About GeneDecksing


    Export disorders for S1PR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S1PR4 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with S1PR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. (PubMed id 9790765)1, 2, 3 Graeler M.H.... Lipp M. (Genomics 1998)
    2. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. (PubMed id 10753843)1, 2, 9 Van Brocklyn J.R....Spiegel S. (Blood 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. (PubMed id 10679247)1, 2 Yamazaki Y.... Ohta H. (Biochem. Biophys. Res. Commun. 2000)
    5. A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. (PubMed id 15298705)1, 9 Holdsworth G....Parrill A.L. (BMC Biochem. 2004)
    6. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. (PubMed id 11919175)1, 9 Idzko M....Norgauer J. (FASEB J. 2002)
    7. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1Pa88-R) agonists. (PubMed id 22119461)1 Guerrero M....Roberts E. (amp 2012)
    8. Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer. (PubMed id 22460268)1 Ohotski J....Edwards J. (Br. J. Cancer 2012)
    9. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. (PubMed id 20837468)1 Long J.S....Pyne N.J. (J. Biol. Chem. 2010)
    10. Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4. (PubMed id 20686109)1 Golfier S....Lipp M. (FASEB J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8698 HGNC: 3170 AceView: EDG6 Ensembl:ENSG00000125910 euGenes: HUgn8698
    ECgene: S1PR4 Kegg: 8698 H-InvDB: S1PR4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S1PR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S1PR4 gene:
    Search GeneIP for patents involving S1PR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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