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Aliases for S1PR4 Gene

Aliases for S1PR4 Gene

  • Sphingosine-1-Phosphate Receptor 4 2 3
  • EDG6 3 4 6
  • S1P4 3 4 6
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 6 2 3
  • Endothelial Differentiation, G-Protein-Coupled Receptor 6 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 6 3 4
  • Sphingosine 1-Phosphate Receptor Edg-6 3 4
  • S1P Receptor Edg-6 3 4
  • S1P Receptor 4 3 4
  • Endothelial Differentiation, G Protein Coupled Receptor 6 3
  • Sphingosine 1-Phosphate Receptor 4 3
  • LPC1 3
  • SLP4 3

External Ids for S1PR4 Gene

Previous HGNC Symbols for S1PR4 Gene

  • EDG6

Previous GeneCards Identifiers for S1PR4 Gene

  • GC19P003130
  • GC19P002945

Summaries for S1PR4 Gene

Entrez Gene Summary for S1PR4 Gene

  • This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR4 Gene

S1PR4 (Sphingosine-1-Phosphate Receptor 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR4 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Tocris Summary for S1PR4 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR4 Gene

Genomics for S1PR4 Gene

Regulatory Elements for S1PR4 Gene

Genomic Location for S1PR4 Gene

Start:
3,172,346 bp from pter
End:
3,180,332 bp from pter
Size:
7,987 bases
Orientation:
Plus strand

Genomic View for S1PR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S1PR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR4 Gene

Proteins for S1PR4 Gene

  • Protein details for S1PR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95977-S1PR4_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 4
    Protein Accession:
    O95977
    Secondary Accessions:
    • D6W612

    Protein attributes for S1PR4 Gene

    Size:
    384 amino acids
    Molecular mass:
    41623 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S1PR4 Gene

neXtProt entry for S1PR4 Gene

Proteomics data for S1PR4 Gene at MOPED

Post-translational modifications for S1PR4 Gene

  • Glycosylation at Asn2 and Asn30
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR4 Gene

Domains for S1PR4 Gene

Gene Families for S1PR4 Gene

HGNC:
  • S1PR :GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate
IUPHAR :

Suggested Antigen Peptide Sequences for S1PR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95977

UniProtKB/Swiss-Prot:

S1PR4_HUMAN :
  • O95977
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR4: view

Function for S1PR4 Gene

Molecular function for S1PR4 Gene

UniProtKB/Swiss-Prot Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Gene Ontology (GO) - Molecular Function for S1PR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10679247
GO:0008289 lipid binding TAS 10679247
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with S1PR4: view
genes like me logo Genes that share phenotypes with S1PR4: view

Animal Models for S1PR4 Gene

MGI Knock Outs for S1PR4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for S1PR4 Gene

Localization for S1PR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR4 Gene COMPARTMENTS Subcellular localization image for S1PR4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for S1PR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9790765
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with S1PR4: view

Pathways for S1PR4 Gene

genes like me logo Genes that share pathways with S1PR4: view

Gene Ontology (GO) - Biological Process for S1PR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0006955 immune response TAS 9790765
GO:0007186 G-protein coupled receptor signaling pathway TAS 9790765
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA --
GO:0007202 activation of phospholipase C activity TAS 10679247
genes like me logo Genes that share ontologies with S1PR4: view

Compounds for S1PR4 Gene

(5) Tocris Compounds for S1PR4 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist [1094042-01-9]
JTE 013 S1P2 receptor antagonist [547756-93-4]
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 [26993-30-6]
VPC 23019 S1P1 and S1P3 antagonist [449173-19-7]
W146 Potent and selective S1P1 receptor antagonist [909725-61-7]

(1) HMDB Compounds for S1PR4 Gene

Compound Synonyms Cas Number PubMed IDs
Sphingosine
  • (-)-D-erythro-Sphingosine
123-78-4

(5) IUPHAR Ligand for S1PR4 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
phytosphingosine 1-phosphate Agonist Agonist 8.8
AFD(R) Agonist Agonist 8.4
dihydrosp?aehingosine?ae-1-phosph?aeate Agonist Agonist 8
compound 26 [PMID:16190743] Agonist Agonist 4.9

(1) Novoseek inferred chemical compound relationships for S1PR4 Gene

Compound -log(P) Hits PubMed IDs
lysophospholipid 87.2 1
genes like me logo Genes that share compounds with S1PR4: view

Transcripts for S1PR4 Gene

mRNA/cDNA for S1PR4 Gene

(49) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S1PR4 Gene

Sphingosine-1-phosphate receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR4 Gene

No ASD Table

Relevant External Links for S1PR4 Gene

GeneLoc Exon Structure for
S1PR4
ECgene alternative splicing isoforms for
S1PR4

Expression for S1PR4 Gene

mRNA expression in normal human tissues for S1PR4 Gene

mRNA differential expression in normal tissues according to GTEx for S1PR4 Gene

This gene is overexpressed in Whole Blood (43.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for S1PR4 Gene

SOURCE GeneReport for Unigene cluster for S1PR4 Gene Hs.662006

mRNA Expression by UniProt/SwissProt for S1PR4 Gene

O95977-S1PR4_HUMAN
Tissue specificity: Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung
genes like me logo Genes that share expressions with S1PR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for S1PR4 Gene

Orthologs for S1PR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR4 35
  • 99.65 (n)
  • 100 (a)
S1PR4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S1PR4 35
  • 85.5 (n)
  • 85.94 (a)
S1PR4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR4 35
  • 87.43 (n)
  • 86.39 (a)
S1PR4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr4 35
  • 81.17 (n)
  • 83.29 (a)
S1pr4 16
S1pr4 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S1PR4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR4 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr4 35
  • 80.37 (n)
  • 83.55 (a)
chicken
(Gallus gallus)
Aves S1PR4 35
  • 65.22 (n)
  • 56.52 (a)
S1PR4 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S1PR4 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr4 35
  • 53.72 (n)
  • 52.07 (a)
zebrafish
(Danio rerio)
Actinopterygii s1pr4 35
  • 55.27 (n)
  • 49 (a)
s1pr4 36
  • 45 (a)
OneToOne
Species with no ortholog for S1PR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR4 Gene

ENSEMBL:
Gene Tree for S1PR4 (if available)
TreeFam:
Gene Tree for S1PR4 (if available)

Paralogs for S1PR4 Gene

Selected SIMAP similar genes for S1PR4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR4: view

Variants for S1PR4 Gene

Sequence variations from dbSNP and Humsavar for S1PR4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs172665 -- 3,177,928(+) TTCTG(C/T)AACGC upstream-variant-2KB
rs184307 -- 3,178,129(+) AACGC(A/C)TCGGG upstream-variant-2KB
rs184308 -- 3,177,919(+) AGTTT(C/T)CCCTT upstream-variant-2KB
rs311629 -- 3,180,805(+) CTGAC(A/G)ACTGC downstream-variant-500B
rs311630 -- 3,180,772(+) TTGAT(G/T)GTACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for S1PR4 Gene

Variant ID Type Subtype PubMed ID
nsv910697 CNV Loss 21882294
nsv509716 CNV Insertion 20534489
nsv910714 CNV Loss 21882294
dgv3648n71 CNV Loss 21882294

Relevant External Links for S1PR4 Gene

HapMap Linkage Disequilibrium report
S1PR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR4 Gene

Disorders for S1PR4 Gene

No disorders were found for S1PR4 Gene.

No data available for UniProtKB/Swiss-Prot for S1PR4 Gene

Publications for S1PR4 Gene

  1. EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. (PMID: 9790765) Graeler M.H. … Lipp M. (Genomics 1998) 2 3 4
  2. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. (PMID: 10753843) Van Brocklyn J.R. … Spiegel S. (Blood 2000) 3 4 23
  3. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. (PMID: 11919175) Idzko M. … Norgauer J. (FASEB J. 2002) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. (PMID: 10679247) Yamazaki Y. … Ohta H. (Biochem. Biophys. Res. Commun. 2000) 3 4

Products for S1PR4 Gene

Sources for S1PR4 Gene

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