Aliases for S1PR4 Gene
- Sphingosine-1-Phosphate Receptor 4 2 3
- EDG6 3 4 6
- S1P4 3 4 6
- Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 6 2 3
- Endothelial Differentiation, G-Protein-Coupled Receptor 6 2 3
- Endothelial Differentiation G-Protein Coupled Receptor 6 3 4
- Sphingosine 1-Phosphate Receptor Edg-6 3 4
External Ids for S1PR4 Gene
Previous HGNC Symbols for S1PR4 Gene
Previous GeneCards Identifiers for S1PR4 Gene
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
GeneCards Summary for S1PR4 Gene
S1PR4 (Sphingosine-1-Phosphate Receptor 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for S1PR4 Gene
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.