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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

S1PR3 Gene

protein-coding GIFtS: 59
GCID: GC09P091606

sphingosine-1-phosphate receptor 3

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG3)

Explore 29 diseases affiliated with
S1PR3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sphingosine-1-Phosphate Receptor 3¹ ²		S1P Receptor 3² ³
EDG3¹ ² ³ ⁵		S1P Receptor Edg-3² ³
EDG-3¹ ²		LPB3²
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 3¹ ²		G Protein-Coupled Receptor, Endothelial Differentiation Gene-3²
Endothelial Differentiation G-Protein Coupled Receptor 3² ³		S1P Receptor EDG3²
Sphingosine 1-Phosphate Receptor Edg-3² ³		Sphingosine 1-Phosphate Receptor 3²
S1P3² ³

External Ids:	HGNC: 3167¹	Entrez Gene: 1903²	Ensembl: ENSG00000213694⁷	OMIM: 601965⁵	UniProtKB: Q99500³

Export aliases for S1PR3 gene to outside databases

Previous GC identifers: GC09P090797 GC09P090799 GC09P061439

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S1PR3:

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been

identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of

angiogenesis and vascular endothelial cell function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that

elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is

capable of mediating S1P-induced cell proliferation and suppression of apoptosis

summary for S1PR3:

Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently

divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of

tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest

density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological

effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal

remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the S1PR3 gene promoter:
AhR Bach1 AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) MIF-1 POU3F2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S1PR3 promoter sequence

Search SABiosciences Chromatin IP Primers for S1PR3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S1PR3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1-q22.2 Ensembl cytogenetic band: 9q22.1 HGNC cytogenetic band: 9q22.1-q22.2

S1PR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR3 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P091606: view genomic region (about GC identifiers)

Start:	91,606,362 bp from pter	End:	91,619,925 bp from pter
Size:	13,564 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500 (See protein sequence)

Recommended Name: Sphingosine 1-phosphate receptor 3

Size: 378 amino acids; 42250 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q5SQD8 Q7Z5I2

Explore the universe of human proteins at neXtProt for S1PR3: NX_Q99500

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99500

S1PR3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005217.2

ENSEMBL proteins:

ENSP00000350878 ENSP00000365006

Reactome Protein details: Q99500
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	Uscn Proteins for S1PR3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9409733

S1PR3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for S1PR3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

S1PR3 for domains About GeneDecksing

4 InterPro domains/families:

IPR004061 S1P_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR004062 EDG3_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q99500

ProtoNet protein and cluster: Q99500

2 Blocks protein families:

IPB004061 Sphingosine 1-phosphate receptor family signature

IPB004062 EDG-3 sphingosine 1-phosphate receptor signature

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that

elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is

capable of mediating S1P-induced cell proliferation and suppression of apoptosis

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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	TAS	10555146
GO:0008289	lipid binding	TAS	9409733
GO:0038036	sphingosine-1-phosphate receptor activity	IEA	--

S1PR3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for S1PR3:

Cell cycle / mitosis defect

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for S1PR3: S1pr3^tm1Jch S1pr3^tm1Rlp
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for S1pr3):

behavior/neurological	cardiovascular system	cellular	hearing/vestibular/ear	homeostasis/metabolism
immune system	integument	limbs/digits/tail	mortality/aging	nervous system
reproductive system	respiratory system

S1PR3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			G alpha (i) signalling events	0.44
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

S1P3 pathway

S1P3 pathway

1.00

Sphingosine 1-phosphate (S1P) pathway

0.40

Lysosphingolipid and LPA receptors

Lysosphingolipid and LPA receptors

1.00

Signal Transduction of S1P Receptor

Signal Transduction of S1P Receptor

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 BioSystems Pathways for S1PR3

	Signal Transduction of S1P Receptor
	S1P3 pathway
	Sphingosine 1-phosphate (S1P) pathway
	Small Ligand GPCRs

5/7 Reactome Pathways for S1PR3 (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events
	Lysosphingolipid and LPA receptors

1 Kegg Pathway (Kegg details for S1PR3):

Neuroactive ligand-receptor interaction

S1PR3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for S1PR3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/159 Interacting proteins for S1PR3 (Q99500³ ENSP00000350878⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 159)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HTR1A	P08908³, ENSP00000316244⁴	I2D: score=3 STRING: ENSP00000316244
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=1 STRING: ENSP00000286548
GNA13	Q14344³, ENSP00000400717⁴	I2D: score=1 STRING: ENSP00000400717
GNAI1	P63096³, ENSP00000343027⁴	I2D: score=1 STRING: ENSP00000343027
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001816	cytokine production	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	10617617
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	9409733

S1PR3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

S1PR3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for S1PR3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Sphingosine-1-phosphate	Endogenous agonist at S1P1-5	[26993-30-6]
VPC 23019	S1P1 and S1P3 antagonist	[449173-19-7]

1 HMDB Compound for S1PR3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sphingosine	(-)-D-erythro-Sphingosine (see all 7)	123-78-4	--

10 Novoseek chemical compound relationships for S1PR3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sphinganine 1-phosphate	91	1	10626811 (1)
sphingosylphosphorylcholine	89.1	4	10381367 (2), 9409733 (1)
sphingosine	84.3	1	16636149 (1)
lysophospholipid	82.1	1	10753843 (1)
suramin	49.2	3	10383399 (2), 11853542 (1)
lipid	40.5	4	10794715 (2), 12775579 (1), 9928946 (1)
phosphatidylinositol	23.6	1	17046831 (1)
calcium	15.1	16	10220556 (6), 9928946 (3), 10383399 (2), 9878524 (2) (see all 5)
cyclic amp	4.11	2	10381367 (1)
tyrosine	0	2	18834877 (1), 11544274 (1)

Search CenterWatch for drugs/clinical trials and news about S1PR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for S1PR3 gene:

NM_005226.3

Unigene Cluster for S1PR3:

Sphingosine-1-phosphate receptor 3

Hs.585118 [show with all ESTs]

Unigene Representative Sequence: AL832194

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000358157(uc004aqe.3) ENST00000375846(uc022bjm.1)

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		hsa-miR-142-3p hsa-miR-4291 hsa-miR-3140-3p hsa-miR-495 hsa-miR-642a hsa-miR-7-2* hsa-miR-646 hsa-miR-9

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Additional cDNA sequence:

AF022139.1 AK094842.1 AK127854.1 AK130650.1 AK130843.1 AK312798.1 AL831887.1 AL832194.1

AY333281.1 BC060827.1 BC069579.1 BC136895.1 BC144432.1

6 DOTS entries:

DT.97766224 DT.97772635 DT.97817570 DT.100705736 DT.101969591 DT.91743675

24/122 AceView cDNA sequences (see all 122):

AA424364 NM_005226 BM729144 BF432401 BC060827 BF475629 AF022139 BF221618

BF589582 BE856033 AK130843 AI874145 AI658766 AL832194 AW079308 AI141395

BX090228 CA447674 AW137598 BM997301 AL536342 CK905851 BM994343 BQ668511

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

S1PR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

S1PR3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Umbilical Veins

Umbilical vein endothelial cells

Endothelium

Kidney

Reproductive System

Kidney

Kidney

Kidney

Lower Urinary Tract

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

See S1PR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S1PR3

SOURCE GeneReport for Unigene cluster: Hs.585118

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver

SABiosciences Expression via Pathway-Focused PCR Arrays including S1PR3:

Notch Signaling Targets in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for S1PR3 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	S1PR3¹	sphingosine-1-phosphate receptor 3	71.17(n) 77.57(a)		431264 XM_428818.2 XP_428818.2
lizard (Anolis carolinensis)	Reptilia	S1PR3⁶	--	68(a)	1 ↔ 1	2(36979920-36981620)
zebrafish (Danio rerio)	Actinopterygii	LOC100332187¹	sphingosine 1-phosphate receptor 3-like	64.71(n) 70.06(a)		100332187 XM_002665838.1 XP_002665884.1

ENSEMBL Gene Tree for S1PR3 (if available)
TreeFam Gene Tree for S1PR3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for S1PR3 gene

CNR1² GPR12² ENSG00000267534² LPAR2² CNR2² S1PR1² GPR3² MC2R²

MC5R² MC4R² S1PR4² MC1R² GPR6² LPAR1² LPAR3² MC3R²

S1PR5²

11 SIMAP similar genes for S1PR3 using alignment to 1 protein entry: S1PR3_HUMAN:

EDG1 S1PR1 S1PR2 LOC441453 S1PR5 EDG2

LPAR1 LPAR2 LPAR3 S1PR4 GPR12

S1PR3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192220740^1,2		--	91604455(+)	`GAGGAC/TAGGGA`	3	--	us2k¹		0	--	--	--	--
rs7022797^1,2	C,F,A,H,	--	91604463(+)	`GGATCT/GTTAGG`	3	--	us2k¹		20		NS EA NA CSA WA	2343
rs184424795^1,2		--	91604465(+)	`ATCTTC/TAGGCA`	3	--	us2k¹		0	--	--	--	--
rs7043711^1,2	C,H,	--	91604469(+)	`TTAGGG/CAAACG`	3	--	us2k¹		10		NA WA CSA	136
rs146821178^1,2		--	91604480(+)	`GAGCCG/TCACTG`	3	--	us2k¹		0	--	--	--	--
rs11137480^1,2	C,F,A,	--	91604577(+)	`TCAGGG/CCTTCT`	3	--	us2k¹		8		NA WA EA	368
rs187902339^1,2		--	91604601(+)	`GCAGAC/TTAGTT`	3	--	us2k¹		0	--	--	--	--
rs139592920^1,2		--	91604671(+)	`AGGAAA/CGGAGA`	3	--	us2k¹		0	--	--	--	--
rs142859121^1,2		--	91604734(+)	`CATCAC/TGGGAA`	3	--	us2k¹		0	--	--	--	--
rs117210461^1,2	F,	--	91604825(+)	`TTATCC/ATGGTT`	3	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for S1PR3 (91606362 - 91619925 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for S1PR3
1 CNV: 70762

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

S1PR3 for disorders           About GeneDecksing

OMIM gene information: 601965    OMIM disorders: --

20/29 diseases for S1PR3 (see all 29):    About MalaCards

mouth disease follicular thyroid carcinoma multiple myeloma thyroid carcinoma

ependymoma multiple sclerosis bladder carcinoma gout

breast cancer myeloma glioblastoma thyroiditis

pertussis gingivitis ovarian cancer gastric cancer

carcinoma breast carcinoma prostate cancer fibrosis

6 Novoseek disease relationships for S1PR3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	19.1	1	18305483 (1)
glioblastoma	12.7	1	12175535 (1)
necrosis	0	1	18658144 (1)
breast cancer	0	1	10493533 (1)
tumors	0	1	18658144 (1)
cancer	0	1	15466859 (1)

Human Genome Epidemiology (HuGE) Navigator: S1PR3 (3 documents)

Export disorders for S1PR3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for S1PR3 gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with S1PR3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PubMed id 9409733)^{1, 2, 3, 9} An S....Goetzl E.J. (1997)
Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PubMed id 8878560)^{1, 2, 3, 9} Yamaguchi F.... Brenner S. (1996)
Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)^{1, 2, 9} Ancellin N. and Hla T. (1999)
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PubMed id 10617617)^{1, 2, 9} An S.... Bleu T. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. (PubMed id 10908314)^{1, 2} Himmel H.M.... Ravens U. (2000)
Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). (PubMed id 19309361)^{1, 9} Jongsma M....Alewijnse A.E. (2009)
Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. (PubMed id 9988698)^{1, 9} Van Brocklyn J.R....Spiegel S. (1999)
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. (PubMed id 17395891)^{1, 9} Singleton P.A....Garcia J.G. (2007)
Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha. (PubMed id 18658144)^{1, 9} Zhao C....Bourgoin S.G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1903	HGNC: 3167	AceView: EDG3	Ensembl:ENSG00000213694	euGenes: HUgn1903
ECgene: S1PR3	Kegg: 1903	H-InvDB: S1PR3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for S1PR3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for S1PR3 gene
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Patent Information for S1PR3 gene:
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GeneCards and IP:
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sphingosine-1-phosphate receptor 3

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