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Aliases for S1PR3 Gene

Aliases for S1PR3 Gene

  • Sphingosine-1-Phosphate Receptor 3 2 3 2
  • EDG3 3 4 6
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 3 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 3 3 4
  • Sphingosine 1-Phosphate Receptor Edg-3 3 4
  • S1P Receptor Edg-3 3 4
  • S1P Receptor 3 3 4
  • S1P3 3 4
  • G Protein-Coupled Receptor, Endothelial Differentiation Gene-3 3
  • Sphingosine 1-Phosphate Receptor 3 3
  • S1P Receptor EDG3 3
  • EDG-3 3
  • LPB3 3

External Ids for S1PR3 Gene

Previous HGNC Symbols for S1PR3 Gene

  • EDG3

Previous GeneCards Identifiers for S1PR3 Gene

  • GC09P090797
  • GC09P090799
  • GC09P091606
  • GC09P061439

Summaries for S1PR3 Gene

Entrez Gene Summary for S1PR3 Gene

  • This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR3 Gene

S1PR3 (Sphingosine-1-Phosphate Receptor 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR3 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Tocris Summary for S1PR3 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR3 Gene

Genomics for S1PR3 Gene

Regulatory Elements for S1PR3 Gene

Genomic Location for S1PR3 Gene

88,991,409 bp from pter
89,005,155 bp from pter
13,747 bases
Plus strand

Genomic View for S1PR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S1PR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR3 Gene

Proteins for S1PR3 Gene

  • Protein details for S1PR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sphingosine 1-phosphate receptor 3
    Protein Accession:
    Secondary Accessions:
    • Q5SQD8
    • Q7Z5I2

    Protein attributes for S1PR3 Gene

    378 amino acids
    Molecular mass:
    42250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for S1PR3 Gene

Proteomics data for S1PR3 Gene at MOPED

Post-translational modifications for S1PR3 Gene

  • Glycosylation at Asn15
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR3 Gene

Domains for S1PR3 Gene

Gene Families for S1PR3 Gene

  • S1PR :GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

Suggested Antigen Peptide Sequences for S1PR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99500
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR3: view

Function for S1PR3 Gene

Molecular function for S1PR3 Gene

UniProtKB/Swiss-Prot Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Gene Ontology (GO) - Molecular Function for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10555146
GO:0005178 integrin binding IPI 24851274
GO:0005515 protein binding IPI 24851274
GO:0008289 lipid binding TAS 9409733
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with S1PR3: view
genes like me logo Genes that share phenotypes with S1PR3: view

Animal Models for S1PR3 Gene

MGI Knock Outs for S1PR3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for S1PR3 Gene

Localization for S1PR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for S1PR3 Gene COMPARTMENTS Subcellular localization image for S1PR3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9409733
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with S1PR3: view

Pathways for S1PR3 Gene

genes like me logo Genes that share pathways with S1PR3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10617617
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with S1PR3: view

Compounds for S1PR3 Gene

(5) Tocris Compounds for S1PR3 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist [1094042-01-9]
JTE 013 S1P2 receptor antagonist [547756-93-4]
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 [26993-30-6]
VPC 23019 S1P1 and S1P3 antagonist [449173-19-7]
W146 Potent and selective S1P1 receptor antagonist [909725-61-7]

(1) HMDB Compounds for S1PR3 Gene

Compound Synonyms Cas Number PubMed IDs
  • (-)-D-erythro-Sphingosine

(6) IUPHAR Ligand for S1PR3 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
FTY720-phosphate Agonist Agonist 8.4
AFD(R) Agonist Agonist 8.4
VPC44116 Antagonist Antagonist 6.52
VPC12249 Agonist Agonist 6.5
compound 26 [PMID:16190743] Agonist Agonist 4.9

(10) Novoseek inferred chemical compound relationships for S1PR3 Gene

Compound -log(P) Hits PubMed IDs
sphinganine 1-phosphate 91 1
sphingosylphosphorylcholine 89.1 3
sphingosine 84.3 1
lysophospholipid 82.1 1
suramin 49.2 3
genes like me logo Genes that share compounds with S1PR3: view

Transcripts for S1PR3 Gene

mRNA/cDNA for S1PR3 Gene

Unigene Clusters for S1PR3 Gene

Sphingosine-1-phosphate receptor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S1PR3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR3 Gene

No ASD Table

Relevant External Links for S1PR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S1PR3 Gene

mRNA expression in normal human tissues for S1PR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR3 Gene

This gene is overexpressed in Esophagus - Muscularis (5.6), Artery - Coronary (4.9), and Esophagus - Gastroesophageal Junction (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S1PR3 Gene

SOURCE GeneReport for Unigene cluster for S1PR3 Gene Hs.585118

mRNA Expression by UniProt/SwissProt for S1PR3 Gene

Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver
genes like me logo Genes that share expressions with S1PR3: view

In Situ Assay Products

Orthologs for S1PR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S1PR3 35
  • 99.74 (n)
  • 99.74 (a)
S1PR3 36
  • 100 (a)
(Bos Taurus)
Mammalia S1PR3 35
  • 86.4 (n)
  • 88 (a)
S1PR3 36
  • 87 (a)
(Canis familiaris)
Mammalia S1PR3 35
  • 86.68 (n)
  • 87.57 (a)
S1PR3 36
  • 83 (a)
(Mus musculus)
Mammalia S1pr3 35
  • 85.5 (n)
  • 87.8 (a)
S1pr3 16
S1pr3 36
  • 88 (a)
(Monodelphis domestica)
Mammalia S1PR3 36
  • 76 (a)
(Rattus norvegicus)
Mammalia S1pr3 35
  • 84.79 (n)
  • 85.94 (a)
(Gallus gallus)
Aves S1PR3 35
  • 70.9 (n)
  • 77.03 (a)
S1PR3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia S1PR3 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr3 35
  • 67.88 (n)
  • 75.76 (a)
(Danio rerio)
Actinopterygii FP085391.2 36
  • 67 (a)
LOC100332187 35
  • 65.69 (n)
  • 71.24 (a)
Species with no ortholog for S1PR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR3 Gene

Gene Tree for S1PR3 (if available)
Gene Tree for S1PR3 (if available)

Paralogs for S1PR3 Gene

Selected SIMAP similar genes for S1PR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR3: view

Variants for S1PR3 Gene

Sequence variations from dbSNP and Humsavar for S1PR3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1867 -- 89,004,869(-) TTCAA(A/G)GTTAG utr-variant-3-prime
rs1129925 -- 89,004,359(+) GCACC(A/G)CTGCA utr-variant-3-prime
rs1134639 -- 89,003,638(+) GGAAA(A/G)AAAAG utr-variant-3-prime
rs1134640 -- 89,003,689(+) TGTTG(A/G)GTTCT utr-variant-3-prime
rs1134641 -- 89,003,779(+) AGCAT(C/T)TGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for S1PR3 Gene

Variant ID Type Subtype PubMed ID
nsv893556 CNV Gain 21882294
esv29340 CNV Gain+Loss 19812545

Relevant External Links for S1PR3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR3 Gene

Disorders for S1PR3 Gene

(6) Novoseek inferred disease relationships for S1PR3 Gene

Disease -log(P) Hits PubMed IDs
inflammation 19.1 1
glioblastoma 12.7 1
necrosis 0 1
breast cancer 0 1
tumors 0 1

Relevant External Links for S1PR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with S1PR3: view

No data available for UniProtKB/Swiss-Prot for S1PR3 Gene

Publications for S1PR3 Gene

  1. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PMID: 8878560) Yamaguchi F. … Brenner S. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PMID: 9409733) An S. … Goetzl E.J. (FEBS Lett. 1997) 2 3 4 23
  3. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PMID: 10383399) Ancellin N. … Hla T. (J. Biol. Chem. 1999) 3 4 23
  4. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S. … Bleu T. (J. Biol. Chem. 2000) 3 4 23
  5. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. (PMID: 10488065) Windh R.T. … Manning D.R. (J. Biol. Chem. 1999) 3 23

Products for S1PR3 Gene

Sources for S1PR3 Gene

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