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Aliases for S1PR3 Gene

Aliases for S1PR3 Gene

  • Sphingosine-1-Phosphate Receptor 3 2 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 3 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 3 3 4
  • Sphingosine 1-Phosphate Receptor Edg-3 3 4
  • S1P Receptor Edg-3 3 4
  • S1P Receptor 3 3 4
  • EDG3 3 4
  • S1P3 3 4
  • G Protein-Coupled Receptor, Endothelial Differentiation Gene-3 3
  • Sphingosine 1-Phosphate Receptor 3 3
  • S1P Receptor EDG3 3
  • EDG-3 3
  • LPB3 3

External Ids for S1PR3 Gene

Previous HGNC Symbols for S1PR3 Gene

  • EDG3

Previous GeneCards Identifiers for S1PR3 Gene

  • GC09P090797
  • GC09P090799
  • GC09P091606
  • GC09P061439

Summaries for S1PR3 Gene

Entrez Gene Summary for S1PR3 Gene

  • This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR3 Gene

S1PR3 (Sphingosine-1-Phosphate Receptor 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.

UniProtKB/Swiss-Prot for S1PR3 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Tocris Summary for S1PR3 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR3 Gene

Genomics for S1PR3 Gene

Regulatory Elements for S1PR3 Gene

Enhancers for S1PR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F088744 1.6 FANTOM5 Ensembl ENCODE 4.8 -244.1 -244144 5.3 ARNT CREB3L1 ARID4B SIN3A FEZF1 YY1 ZNF143 ZNF207 FOS MXD4 S1PR3 MIR4289 GC09M088841
GH09F088948 1.3 FANTOM5 Ensembl ENCODE 4.7 -41.0 -41019 3.2 GTF2F1 TBP SOX13 TAL1 JUN MAX CEBPG BRCA1 RFX5 GATA3 C9orf47 S1PR3 PCNPP2 PIR55815
GH09F088952 0.8 Ensembl ENCODE 6.2 -37.7 -37693 1.6 POLR2A ATF3 SMARCA4 HNF4G PRDM1 YY1 NR2F2 S1PR3 PCNPP2 PIR55815
GH09F088921 1.5 FANTOM5 Ensembl ENCODE 2.9 -68.3 -68309 3.8 PKNOX1 KLF17 SIN3A FEZF1 DNMT3B RARA ZNF335 FOS THAP11 SP5 S1PR3 C9orf47 SECISBP2 PIR55815 PCNPP2
GH09F088941 0.7 ENCODE 6.2 -49.1 -49112 2.2 ESRRA PKNOX1 DPF2 ZNF217 MBD2 SREBF1 GATA3 RAD51 CTBP1 MTA1 S1PR3 C9orf47 PCNPP2 PIR55815
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S1PR3 on UCSC Golden Path with GeneCards custom track

Promoters for S1PR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001307819 691 3401 CTCF MAZ HLF TEAD4 SP2 SIN3A NR3C1 RAD21 POLR2A ZNF692

Genomic Location for S1PR3 Gene

Chromosome:
9
Start:
88,991,409 bp from pter
End:
89,005,155 bp from pter
Size:
13,747 bases
Orientation:
Plus strand

Genomic View for S1PR3 Gene

Genes around S1PR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR3 Gene

Proteins for S1PR3 Gene

  • Protein details for S1PR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99500-S1PR3_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 3
    Protein Accession:
    Q99500
    Secondary Accessions:
    • Q5SQD8
    • Q7Z5I2

    Protein attributes for S1PR3 Gene

    Size:
    378 amino acids
    Molecular mass:
    42250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for S1PR3 Gene

Post-translational modifications for S1PR3 Gene

  • Glycosylation at Asn 15
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR3 Gene

Domains & Families for S1PR3 Gene

Gene Families for S1PR3 Gene

Suggested Antigen Peptide Sequences for S1PR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99500

UniProtKB/Swiss-Prot:

S1PR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR3: view

Function for S1PR3 Gene

Molecular function for S1PR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Gene Ontology (GO) - Molecular Function for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10555146
GO:0005178 integrin binding IPI 24851274
GO:0005515 protein binding IPI 24851274
GO:0008289 lipid binding TAS 9409733
genes like me logo Genes that share ontologies with S1PR3: view
genes like me logo Genes that share phenotypes with S1PR3: view

Animal Models for S1PR3 Gene

MGI Knock Outs for S1PR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for S1PR3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for S1PR3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR3 Gene

Localization for S1PR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S1PR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9409733
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with S1PR3: view

Pathways & Interactions for S1PR3 Gene

genes like me logo Genes that share pathways with S1PR3: view

SIGNOR curated interactions for S1PR3 Gene

Activates:

Gene Ontology (GO) - Biological Process for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0006954 inflammatory response IEA,TAS --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10617617
genes like me logo Genes that share ontologies with S1PR3: view

Drugs & Compounds for S1PR3 Gene

(29) Drugs for S1PR3 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0
CYM 5442 hydrochloride Pharma Selective S1P1 receptor agonist 0
JTE 013 Pharma S1P2 receptor antagonist 0
VPC 23019 Pharma S1P1/S1P3 receptor antagonist, S1P1 and S1P3 antagonist 0

(4) Additional Compounds for S1PR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for S1PR3 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
JTE 013 S1P2 receptor antagonist 547756-93-4
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
VPC 23019 S1P1 and S1P3 antagonist 449173-19-7
W146 Potent and selective S1P1 receptor antagonist 909725-61-7

(15) ApexBio Compounds for S1PR3 Gene

Compound Action Cas Number
BAF312 (Siponimod) S1P agonist,potent and selective 1230487-00-9
CS 2100 913827-99-3
CYM 50260 1355026-60-6
CYM 50308 1345858-76-5
CYM 50358 hydrochloride
CYM 5442 hydrochloride 1094042-01-9
CYM 5541 945128-26-7
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
JTE 013 547756-93-4
N,N-Dimethylsphingosine 119567-63-4
RP 001 hydrochloride 1306761-53-4
SEW 2871 256414-75-2
TC-G 1006 1324003-64-6
VPC 23019 S1P1/S1P3 receptor antagonist 449173-19-7
W146 909725-61-7
genes like me logo Genes that share compounds with S1PR3: view

Transcripts for S1PR3 Gene

mRNA/cDNA for S1PR3 Gene

Unigene Clusters for S1PR3 Gene

Sphingosine-1-phosphate receptor 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for S1PR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR3 Gene

No ASD Table

Relevant External Links for S1PR3 Gene

GeneLoc Exon Structure for
S1PR3
ECgene alternative splicing isoforms for
S1PR3

Expression for S1PR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S1PR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR3 Gene

This gene is overexpressed in Esophagus - Muscularis (x5.6), Artery - Coronary (x4.9), and Esophagus - Gastroesophageal Junction (x4.4).

Protein differential expression in normal tissues from HIPED for S1PR3 Gene

This gene is overexpressed in Prostate (54.8) and Fetal heart (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S1PR3 Gene



Protein tissue co-expression partners for S1PR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of S1PR3 Gene:

S1PR3

SOURCE GeneReport for Unigene cluster for S1PR3 Gene:

Hs.585118

mRNA Expression by UniProt/SwissProt for S1PR3 Gene:

Q99500-S1PR3_HUMAN
Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
genes like me logo Genes that share expression patterns with S1PR3: view

Primer Products

Orthologs for S1PR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR3 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia S1PR3 34 35
  • 86.68 (n)
cow
(Bos Taurus)
Mammalia S1PR3 34 35
  • 86.4 (n)
mouse
(Mus musculus)
Mammalia S1pr3 34 16 35
  • 85.5 (n)
rat
(Rattus norvegicus)
Mammalia S1pr3 34
  • 84.79 (n)
oppossum
(Monodelphis domestica)
Mammalia S1PR3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves S1PR3 34 35
  • 70.9 (n)
lizard
(Anolis carolinensis)
Reptilia S1PR3 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr3 34
  • 67.88 (n)
zebrafish
(Danio rerio)
Actinopterygii FP085391.2 35
  • 67 (a)
OneToOne
LOC100332187 34
  • 65.69 (n)
Species where no ortholog for S1PR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR3 Gene

ENSEMBL:
Gene Tree for S1PR3 (if available)
TreeFam:
Gene Tree for S1PR3 (if available)

Paralogs for S1PR3 Gene

Paralogs for S1PR3 Gene

(11) SIMAP similar genes for S1PR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR3: view

Variants for S1PR3 Gene

Sequence variations from dbSNP and Humsavar for S1PR3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10648003 -- 88,990,394(+) ACAAA(-/GAATC)CTCAA upstream-variant-2KB
rs10867149 -- 88,993,713(+) TAACA(C/T)GTTTC intron-variant, utr-variant-3-prime
rs111258555 -- 89,002,304(+) AAGAA(C/T)GCAGC reference, synonymous-codon
rs111279714 -- 88,994,238(+) CCCCC(A/C)CTCCC intron-variant, utr-variant-3-prime
rs11137480 -- 88,989,662(+) TCAGG(C/G)CTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S1PR3 Gene

Variant ID Type Subtype PubMed ID
esv3621014 CNV gain 21293372
esv29340 CNV gain+loss 19812545

Variation tolerance for S1PR3 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S1PR3 Gene

Human Gene Mutation Database (HGMD)
S1PR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
S1PR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR3 Gene

Disorders for S1PR3 Gene

Relevant External Links for S1PR3

Genetic Association Database (GAD)
S1PR3
Human Genome Epidemiology (HuGE) Navigator
S1PR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S1PR3

No disorders were found for S1PR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S1PR3 Gene

Publications for S1PR3 Gene

  1. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PMID: 9409733) An S. … Goetzl E.J. (FEBS Lett. 1997) 2 3 4 22 64
  2. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PMID: 8878560) Yamaguchi F. … Brenner S. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 22 64
  3. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S. … Bleu T. (J. Biol. Chem. 2000) 3 4 22 64
  4. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PMID: 10383399) Ancellin N. … Hla T. (J. Biol. Chem. 1999) 3 4 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for S1PR3 Gene

Sources for S1PR3 Gene

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