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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S1PR3 Gene

protein-coding   GIFtS: 62
GCID: GC09P091606

Sphingosine-1-Phosphate Receptor 3

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sphingosine-1-Phosphate Receptor 31 2     S1P Receptor Edg-32 3
EDG31 2 3 5     EDG-32
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 31 2     LPB32
Endothelial Differentiation G-Protein Coupled Receptor 32 3     G Protein-Coupled Receptor, Endothelial Differentiation Gene-32
Sphingosine 1-Phosphate Receptor Edg-32 3     S1P Receptor EDG32
S1P32 3     Sphingosine 1-Phosphate Receptor 32
S1P Receptor 32 3     

External Ids:    HGNC: 31671   Entrez Gene: 19032   Ensembl: ENSG000002136947   OMIM: 6019655   UniProtKB: Q995003   

Export aliases for S1PR3 gene to outside databases

Previous GC identifers: GC09P090797 GC09P090799 GC09P061439


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S1PR3 Gene:
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has
been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of
angiogenesis and vascular endothelial cell function. (provided by RefSeq, Jul 2008)

GeneCards Summary for S1PR3 Gene: 
S1PR3 (sphingosine-1-phosphate receptor 3) is a protein-coding gene. Diseases associated with S1PR3 include endotheliitis, and mouth disease, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include sphingosine-1-phosphate receptor activity and G-protein coupled receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma
cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

summary for S1PR3 Gene:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S1PR3 gene promoter:
         AhR   Bach1   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   MIF-1   POU3F2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS1PR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for S1PR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S1PR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1-q22.2   Ensembl cytogenetic band:  9q22.1   HGNC cytogenetic band: 9q22.1-q22.2

S1PR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P091606:  view genomic region     (about GC identifiers)

Start:
91,606,362 bp from pter      End:
91,619,925 bp from pter
Size:
13,564 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 3  
Size: 378 amino acids; 42250 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5SQD8 Q7Z5I2

Explore the universe of human proteins at neXtProt for S1PR3: NX_Q99500

Explore proteomics data for S1PR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99500

  • S1PR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    S1PR3 Protein Expression
    REFSEQ proteins: NP_005217.2  
    ENSEMBL proteins: 
     ENSP00000350878   ENSP00000365006  
    Reactome Protein details: Q99500
    Human Recombinant Protein Products for S1PR3: 
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    Novus Biologicals S1PR3 Proteins
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for S1PR3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9409733
    GO:0016021integral to membrane ----

    S1PR3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    S1PR: GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

    IUPHAR Guide to PHARMACOLOGY protein family classification: S1P3 receptor 
    Lysophospholipid (S1P) receptors

    4 InterPro protein domains:
     IPR004061 S1P_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004062 EDG3_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q99500

    ProtoNet protein and cluster: Q99500

    2 Blocks protein domains:
    IPB004061 Sphingosine 1-phosphate receptor family signature
    IPB004062 EDG-3 sphingosine 1-phosphate receptor signature


    UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500
    Similarity: Belongs to the G-protein coupled receptor 1 family


    S1PR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S1PR3_HUMAN, Q99500
    Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
    that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma
    cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10555146
    GO:0008289lipid binding TAS9409733
    GO:0038036sphingosine-1-phosphate receptor activity IEA--
         
    S1PR3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for S1PR3:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S1pr3):
     behavior/neurological  cardiovascular system  cellular  hearing/vestibular/ear  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     reproductive system  respiratory system 

    S1PR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for S1PR3: S1pr3tm1Jch S1pr3tm1Rlp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for S1PR3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for S1PR3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3S1P3 pathway
    S1P3 pathway0.44
    Sphingosine 1-phosphate (S1P) pathway0.40
    4Prostanoid ligand receptors
    Small Ligand GPCRs0.40
    5Signal Transduction of S1P Receptor
    Signal Transduction of S1P Receptor

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for S1PR3
        Signal Transduction of S1P Receptor
    S1P3 pathway
    Sphingosine 1-phosphate (S1P) pathway
    Small Ligand GPCRs

    5/7        Reactome Pathways for S1PR3 (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    Lysosphingolipid and LPA receptors


    1         Kegg Pathway  (Kegg details for S1PR3):
        Neuroactive ligand-receptor interaction


    S1PR3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S1PR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/159 Interacting proteins for S1PR3 (Q995003 ENSP000003508784) via UniProtKB, MINT, STRING, and/or I2D (see all 159)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTR1AP089083, ENSP000003162444I2D: score=3 STRING: ENSP00000316244
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    GNA13Q143443, ENSP000004007174I2D: score=1 STRING: ENSP00000400717
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    ACKR3ENSP000002729284STRING: ENSP00000272928
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS10617617
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007204elevation of cytosolic calcium ion concentration TAS9409733

    S1PR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S1PR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for S1PR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    CYM 5442 hydrochlorideSelective S1P1 receptor agonist[1094042-01-9]
    JTE 013S1P2 receptor antagonist[547756-93-4]
    VPC 23019S1P1 and S1P3 antagonist[449173-19-7]
    W146Potent and selective S1P1 receptor antagonist[909725-62-8]

    1 HMDB Compound for S1PR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--

    6 IUPHAR Ligands for S1PR3 (S1P3 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    sphingosine 1-phosphate
    AgonistAgonist8.7 - 8.9611705398 11967257
    FTY720-phosphate
    AgonistAgonist8.411967257
    AFD(R)
    AgonistAgonist8.411967257
    VPC44116
    AntagonistAntagonist6.5217113298
    VPC12249
    AgonistAgonist6.517113298
    compound 26 [PMID:16190743]
    AgonistAgonist4.916190743

    10 Novoseek inferred chemical compound relationships for S1PR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphinganine 1-phosphate 91 1 10626811 (1)
    sphingosylphosphorylcholine 89.1 4 10381367 (2), 9409733 (1)
    sphingosine 84.3 1 16636149 (1)
    lysophospholipid 82.1 1 10753843 (1)
    suramin 49.2 3 10383399 (2), 11853542 (1)
    lipid 40.5 4 10794715 (2), 12775579 (1), 9928946 (1)
    phosphatidylinositol 23.6 1 17046831 (1)
    calcium 15.1 16 10220556 (6), 9928946 (3), 10383399 (2), 9878524 (2) (see all 5)
    cyclic amp 4.11 2 10381367 (1)
    tyrosine 0 2 18834877 (1), 11544274 (1)

    Search CenterWatch for drugs/clinical trials and news about S1PR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for S1PR3 gene: 
    NM_005226.3  

    Unigene Cluster for S1PR3:

    Sphingosine-1-phosphate receptor 3
    Hs.585118  [show with all ESTs]
    Unigene Representative Sequence: AL832194
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358157(uc004aqe.3) ENST00000375846(uc022bjm.1)
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    Additional mRNA sequence: 

    AF022139.1 AK094842.1 AK127854.1 AK130650.1 AK130843.1 AK312798.1 AL831887.1 AL832194.1 
    AY333281.1 BC060827.1 BC069579.1 BC136895.1 BC144432.1 

    6 DOTS entries:

    DT.97766224  DT.97772635  DT.97817570  DT.100705736  DT.101969591  DT.91743675 

    24/122 AceView cDNA sequences (see all 122):

    BC060827 NM_005226 BM994343 CA447674 CK905851 BM705261 BF475629 AA234027 
    AI473541 BF432401 BX090228 AA424364 AA375607 AI658766 BF221618 AA662564 
    AL832194 AI874145 BE856033 AK130843 AL536342 BQ668511 AF022139 CA427601 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S1PR3 expression in normal human tissues (normalized intensities)      S1PR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    S1PR3 Expression
    About this image


    S1PR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Kidney (Urinary System)    fully expand to see all 8 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
             visceral organ/mesonephros of female/mesonephric mesenchyme of female mesonephros   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             Ureter
             visceral organ   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             Human Skeletal Muscle Myoblast (HSkMM)   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor EN7
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros

    See S1PR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S1PR3

    SOURCE GeneReport for Unigene cluster: Hs.585118

    UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500
    Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including S1PR3: 
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              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S1pr31 , 5 sphingosine-1-phosphate receptor 31, 5 85.55(n)1
    88.03(a)1
      13 (26.12 cM)5
    136101  NM_010101.41  NP_034231.11 
     514086185 
    chicken
    (Gallus gallus)
    Aves S1PR31 sphingosine-1-phosphate receptor 3 71.17(n)
    77.57(a)
      431264  XM_428818.2  XP_428818.2 
    lizard
    (Anolis carolinensis)
    Reptilia S1PR36
    Uncharacterized protein
    71(a)
    1 ↔ 1
    2(36979920-36981620)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003321871 sphingosine 1-phosphate receptor 3-like 64.71(n)
    70.06(a)
      100332187  XM_002665838.1  XP_002665884.1 


    ENSEMBL Gene Tree for S1PR3 (if available)
    TreeFam Gene Tree for S1PR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S1PR3 gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR22  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    11 SIMAP similar genes for S1PR3 using alignment to 1 protein entry:     S1PR3_HUMAN:
    EDG1    S1PR1    S1PR2    LOC441453    S1PR5    EDG2
    LPAR1    LPAR2    LPAR3    S1PR4    GPR12

    S1PR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/212 SNPs in S1PR3 are shown (see all 212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713585521,2
    C--61447943(-) CGTGG-/GAAGATCC 1 -- int11Minor allele frequency- GAA:0.00NA 2
    rs65593331,2
    C,F,A,H--91611581(+) tgcagG/Cgtccg 1 -- int117Minor allele frequency- C:0.08NS EA NA WA 2014
    rs1885892161,2
    C--91611780(+) CAGGGC/TGGGGT 1 -- int10--------
    rs1916489071,2
    --91611781(+) AGGGCA/GGGGTG 1 -- int10--------
    rs1385179161,2
    --91611842(+) AGGAGC/TGGAGG 1 -- int10--------
    rs1844921091,2
    --91611881(+) CCGTGC/TGCAAT 1 -- int10--------
    rs412860431,2
    C--91611932(+) AGCACG/TTAACT 1 -- int10--------
    rs1901476821,2
    --91612026(+) CTTATG/TCAAAA 1 -- int10--------
    rs1180192531,2
    F--91612043(+) GAATCA/GTATTT 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1462695931,2
    --91612102(+) ATTATA/CAGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for S1PR3 (91606362 - 91619925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for S1PR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893556CNV Gain21882294
    esv29340CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): S1PR3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing S1PR3
    DNA2.0 Custom Variant and Variant Library Synthesis for S1PR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601965    OMIM disorders: --

    20/29 diseases for S1PR3 (see all 29):    About MalaCards
    endotheliitis    mouth disease    follicular thyroid carcinoma    ependymoma
    gout    bladder carcinoma    glioblastoma    pertussis
    gingivitis    abdominal aortic aneurysm    multiple myeloma    aortic aneurysm
    myeloma    thyroid cancer    thyroiditis    multiple sclerosis
    hypoxia    lung adenocarcinoma    neuroblastoma    cerebritis


    S1PR3 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for S1PR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 19.1 1 18305483 (1)
    glioblastoma 12.7 1 12175535 (1)
    necrosis 0 1 18658144 (1)
    breast cancer 0 1 10493533 (1)
    tumors 0 1 18658144 (1)
    cancer 0 1 15466859 (1)

    Genetic Association Database (GAD): S1PR3
    Human Genome Epidemiology (HuGE) Navigator: S1PR3 (3 documents)

    Export disorders for S1PR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S1PR3 gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with S1PR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PubMed id 9409733)1, 2, 3, 9 An S....Goetzl E.J. (1997)
    2. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PubMed id 8878560)1, 2, 3, 9 Yamaguchi F.... Brenner S. (1996)
    3. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)1, 2, 9 Ancellin N. and Hla T. (1999)
    4. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PubMed id 10617617)1, 2, 9 An S.... Bleu T. (2000)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. (PubMed id 10908314)1, 2 Himmel H.M.... Ravens U. (2000)
    8. Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). (PubMed id 19309361)1, 9 Jongsma M....Alewijnse A.E. (2009)
    9. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. (PubMed id 9988698)1, 9 Van Brocklyn J.R....Spiegel S. (1999)
    10. Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. (PubMed id 17395891)1, 9 Singleton P.A....Garcia J.G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1903 HGNC: 3167 AceView: EDG3 Ensembl:ENSG00000213694 euGenes: HUgn1903
    ECgene: S1PR3 Kegg: 1903 H-InvDB: S1PR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S1PR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for S1PR3 gene:
    Search GeneIP for patents involving S1PR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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