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Aliases for S1PR3 Gene

Aliases for S1PR3 Gene

  • Sphingosine-1-Phosphate Receptor 3 2 3 2 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 3 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 3 3 4
  • Sphingosine 1-Phosphate Receptor Edg-3 3 4
  • S1P Receptor Edg-3 3 4
  • S1P Receptor 3 3 4
  • EDG3 3 4
  • S1P3 3 4
  • G Protein-Coupled Receptor, Endothelial Differentiation Gene-3 3
  • S1P Receptor EDG3 3
  • EDG-3 3
  • LPB3 3

External Ids for S1PR3 Gene

Previous HGNC Symbols for S1PR3 Gene

  • EDG3

Previous GeneCards Identifiers for S1PR3 Gene

  • GC09P090797
  • GC09P090799
  • GC09P091606
  • GC09P061439

Summaries for S1PR3 Gene

Entrez Gene Summary for S1PR3 Gene

  • This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR3 Gene

S1PR3 (Sphingosine-1-Phosphate Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and integrin binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR3 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Tocris Summary for S1PR3 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR3 Gene

Genomics for S1PR3 Gene

Regulatory Elements for S1PR3 Gene

Enhancers for S1PR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around S1PR3 on UCSC Golden Path with GeneCards custom track

Promoters for S1PR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S1PR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for S1PR3 Gene

Chromosome:
9
Start:
88,991,409 bp from pter
End:
89,005,155 bp from pter
Size:
13,747 bases
Orientation:
Plus strand

Genomic View for S1PR3 Gene

Genes around S1PR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR3 Gene

Proteins for S1PR3 Gene

  • Protein details for S1PR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99500-S1PR3_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 3
    Protein Accession:
    Q99500
    Secondary Accessions:
    • Q5SQD8
    • Q7Z5I2

    Protein attributes for S1PR3 Gene

    Size:
    378 amino acids
    Molecular mass:
    42250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for S1PR3 Gene

Proteomics data for S1PR3 Gene at MOPED

Post-translational modifications for S1PR3 Gene

  • Glycosylation at Asn 15
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S1PR3 Gene

Domains & Families for S1PR3 Gene

Gene Families for S1PR3 Gene

Suggested Antigen Peptide Sequences for S1PR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99500

UniProtKB/Swiss-Prot:

S1PR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR3: view

Function for S1PR3 Gene

Molecular function for S1PR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Gene Ontology (GO) - Molecular Function for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding TAS 9409733
genes like me logo Genes that share ontologies with S1PR3: view
genes like me logo Genes that share phenotypes with S1PR3: view

Animal Models for S1PR3 Gene

MGI Knock Outs for S1PR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for S1PR3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR3 Gene

Localization for S1PR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR3 Gene COMPARTMENTS Subcellular localization image for S1PR3 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with S1PR3: view

Pathways & Interactions for S1PR3 Gene

genes like me logo Genes that share pathways with S1PR3: view

SIGNOR curated interactions for S1PR3 Gene

Activates:

Gene Ontology (GO) - Biological Process for S1PR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 10617617
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 9409733
GO:0032651 regulation of interleukin-1 beta production IEA --
genes like me logo Genes that share ontologies with S1PR3: view

Drugs & Compounds for S1PR3 Gene

(15) Drugs for S1PR3 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0
AFD(R) Pharma Agonist 0
compound 26 [PMID:16190743] Pharma Agonist 0
FTY720-phosphate Pharma Agonist 0

(8) Additional Compounds for S1PR3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CYM 5442 hydrochloride
1094042-01-9
RP 001 hydrochloride
1306761-53-4
SEW 2871
256414-75-2
TC-SP 14
1257093-40-5

(5) Tocris Compounds for S1PR3 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
RP 001 hydrochloride Potent S1P1 agonist 1306761-53-4
SEW 2871 Cell-permeable, selective S1P1 receptor agonist 256414-75-2
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
TC-SP 14 Potent S1P1 receptor agonist 1257093-40-5

(1) ApexBio Compounds for S1PR3 Gene

Compound Action Cas Number
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
genes like me logo Genes that share compounds with S1PR3: view

Transcripts for S1PR3 Gene

mRNA/cDNA for S1PR3 Gene

Unigene Clusters for S1PR3 Gene

Sphingosine-1-phosphate receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR3 Gene

No ASD Table

Relevant External Links for S1PR3 Gene

GeneLoc Exon Structure for
S1PR3
ECgene alternative splicing isoforms for
S1PR3

Expression for S1PR3 Gene

mRNA expression in normal human tissues for S1PR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR3 Gene

This gene is overexpressed in Esophagus - Muscularis (x5.6), Artery - Coronary (x4.9), and Esophagus - Gastroesophageal Junction (x4.4).

Protein differential expression in normal tissues from HIPED for S1PR3 Gene

This gene is overexpressed in Prostate (54.8) and Fetal heart (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S1PR3 Gene



SOURCE GeneReport for Unigene cluster for S1PR3 Gene Hs.585118

mRNA Expression by UniProt/SwissProt for S1PR3 Gene

Q99500-S1PR3_HUMAN
Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
genes like me logo Genes that share expression patterns with S1PR3: view

Protein tissue co-expression partners for S1PR3 Gene

Primer Products

Orthologs for S1PR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S1PR3 35
  • 86.4 (n)
  • 88 (a)
S1PR3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR3 35
  • 86.68 (n)
  • 87.57 (a)
S1PR3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr3 35
  • 85.5 (n)
  • 87.8 (a)
S1pr3 16
S1pr3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S1PR3 35
  • 99.74 (n)
  • 99.74 (a)
S1PR3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr3 35
  • 84.79 (n)
  • 85.94 (a)
oppossum
(Monodelphis domestica)
Mammalia S1PR3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves S1PR3 35
  • 70.9 (n)
  • 77.03 (a)
S1PR3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S1PR3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr3 35
  • 67.88 (n)
  • 75.76 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332187 35
  • 65.69 (n)
  • 71.24 (a)
FP085391.2 36
  • 67 (a)
OneToOne
Species with no ortholog for S1PR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR3 Gene

ENSEMBL:
Gene Tree for S1PR3 (if available)
TreeFam:
Gene Tree for S1PR3 (if available)

Paralogs for S1PR3 Gene

Paralogs for S1PR3 Gene

(11) SIMAP similar genes for S1PR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR3: view

Variants for S1PR3 Gene

Sequence variations from dbSNP and Humsavar for S1PR3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs34075341 - 89,001,928(+) GCTGC(A/G)GACCG reference, missense
rs1129925 -- 89,004,359(+) GCACC(A/G)CTGCA utr-variant-3-prime
rs1134639 -- 89,003,638(+) GGAAA(A/G)AAAAG utr-variant-3-prime
rs1134640 -- 89,003,689(+) TGTTG(A/G)GTTCT utr-variant-3-prime
rs1134641 -- 89,003,779(+) AGCAT(C/T)TGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for S1PR3 Gene

Variant ID Type Subtype PubMed ID
nsv893556 CNV Gain 21882294
esv29340 CNV Gain+Loss 19812545

Variation tolerance for S1PR3 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S1PR3 Gene

Human Gene Mutation Database (HGMD)
S1PR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR3 Gene

Disorders for S1PR3 Gene

Relevant External Links for S1PR3

Genetic Association Database (GAD)
S1PR3
Human Genome Epidemiology (HuGE) Navigator
S1PR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S1PR3

No disorders were found for S1PR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S1PR3 Gene

Publications for S1PR3 Gene

  1. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PMID: 9409733) An S. … Goetzl E.J. (FEBS Lett. 1997) 2 3 4 23 67
  2. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PMID: 8878560) Yamaguchi F. … Brenner S. (Biochem. Biophys. Res. Commun. 1996) 2 3 23
  3. Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). (PMID: 19309361) Jongsma M. … Alewijnse A.E. (Br. J. Pharmacol. 2009) 3 23
  4. Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. (PMID: 19633297) Martin J.L. … Baxter R.C. (J. Biol. Chem. 2009) 3 23
  5. Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha. (PMID: 18658144) Zhao C. … Bourgoin S.G. (J. Lipid Res. 2008) 3 23

Products for S1PR3 Gene

Sources for S1PR3 Gene

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