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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S1PR2 Gene

protein-coding   GIFtS: 55
GCID: GC19M010332

sphingosine-1-phosphate receptor 2

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG5)
 Explore 21 diseases affiliated with
S1PR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for S1PR2    

Aliases
for S1PR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sphingosine-1-Phosphate Receptor 21 2     S1P22 3
EDG51 2 3 5     S1P Receptor 22 3
AGR161 2     S1P Receptor Edg-52 3
Gpcr131 2     EDG-52
H2181 2     LPB22
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 51 2     S1P Receptor EDG52
Endothelial Differentiation G-Protein Coupled Receptor 52 3     Sphingosine 1-Phosphate Receptor 22
Sphingosine 1-Phosphate Receptor Edg-52 3     

External Ids:    HGNC: 31691   Entrez Gene: 92942   Ensembl: ENSG000001758987   OMIM: 6051115   UniProtKB: O951363   

Export aliases for S1PR2 gene to outside databases

Previous GC identifers: GC19M010193 GC19M009912


Summaries
for S1PR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for S1PR2:
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein
participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that
elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is
capable of mediating S1P-induced cell proliferation and suppression of apoptosis

summary for S1PR2:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR2


Genomic Views
for S1PR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S1PR2 gene promoter:
         MyoD   NF-kappaB   AP-2gamma   C/EBPalpha   CREB   RORalpha1   Ik-2   Zic1   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S1PR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for S1PR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S1PR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19q13

S1PR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010332:  view genomic region     (about GC identifiers)

Start:
 10,332,109 bp from pter      End:
 10,341,948 bp from pter
Size:
 9,840 bases      Orientation:
 minus strand

Proteins
for S1PR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 2  
Size: 353 amino acids; 38867 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for S1PR2:
1ZTI (3D)    
Secondary accessions: Q86UN8

Explore the universe of human proteins at neXtProt for S1PR2: NX_O95136

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95136

    • S1PR2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_004221.3  Reactome Protein details: O95136
    Human Recombinant Protein Products: 
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    Uscn Proteins for S1PR2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    S1PR2 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for S1PR2

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    Uscn ELISAs and CLIAs for S1PR2

    Protein Domains /
    Families
    for S1PR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    S1PR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR004061 S1P_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004063 EDG5_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O95136

    ProtoNet protein and cluster: O95136

    2 Blocks protein families:
    IPB004061 Sphingosine 1-phosphate receptor family signature
    IPB004063 EDG-5 sphingosine 1-phosphate receptor signature


    UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for S1PR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136
    Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that
    elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is
    capable of mediating S1P-induced cell proliferation and suppression of apoptosis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat S1PR2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate S1PR2 (see all 35):
    hsa-miR-301a hsa-miR-4267 hsa-miR-3167 hsa-miR-637 hsa-miR-149 hsa-miR-130b hsa-miR-1290 hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: S1PR2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S1PR2 

    Cell Line
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    Search LifeMap BioReagents cell lines for S1PR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8087418
    GO:0008289lipid binding TAS10617617
    GO:0038036sphingosine-1-phosphate receptor activity IEA--


    S1PR2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for S1PR2:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-outs for S1PR2: S1pr2tm1Jch S1pr2tm1Rlp S1pr2tm1Ytak
         13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for S1pr2):
     behavior/neurological  cardiovascular system  cellular  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     pigmentation  reproductive system  tumorigenesis 

    S1PR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for S1PR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    2S1P3 pathway
    		S1P3 pathway1.00
    		Sphingosine 1-phosphate (S1P) pathway0.40
    		S1P2 pathway0.44
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Lysosphingolipid and LPA receptors
    		Lysosphingolipid and LPA receptors1.00
    5Signal Transduction of S1P Receptor
    		Signal Transduction of S1P Receptor1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5 BioSystems Pathways for S1PR2 
        Signal Transduction of S1P Receptor
    S1P2 pathway
    Small Ligand GPCRs
    Sphingosine 1-phosphate (S1P) pathway
    S1P3 pathway

    5/7        Reactome Pathways for S1PR2 (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    Lysosphingolipid and LPA receptors


    1         Kegg Pathway  (Kegg details for S1PR2):
        Neuroactive ligand-receptor interaction


    S1PR2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S1PR2

    3 Interacting proteins for S1PR2 (O951363) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA13Q143443I2D: score=2 
    GNAQP501483I2D: score=2 
    GNAI1P630963I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS10617617
    GO:0007186G-protein coupled receptor signaling pathway TAS10617617
    GO:0007610behavior IEA--
    GO:0008284positive regulation of cell proliferation TAS10617617


    S1PR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for S1PR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S1PR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for S1PR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    JTE 013S1P2 receptor antagonist[547756-93-4]

    1 HMDB Compound for S1PR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--
    5 Novoseek chemical compound relationships for S1PR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphinganine 1-phosphate 90.9 1 10626811 (1)
    sphingosylphosphorylcholine 87.2 5 9854026 (2), 9409733 (1), 10381367 (1)
    sphingosine 84.6 2 10617617 (1), 12445827 (1)
    lysophospholipid 84.2 1 10753843 (1)
    calcium 13.9 14 10220556 (6), 9854026 (3), 10383399 (1)

    Search CenterWatch for drugs/clinical trials and news about S1PR2 

    Transcripts
    for S1PR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for S1PR2 gene: 
    NM_004230.3  

    Unigene Cluster for S1PR2:

    Sphingosine-1-phosphate receptor 2
    Hs.655405  [show with all ESTs]
    Unigene Representative Sequence: NM_004230
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317726(lincRNA)(uc002mnl.2) ENST00000589757(lincRNA)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat S1PR2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate S1PR2 (see all 35):
    hsa-miR-301a hsa-miR-4267 hsa-miR-3167 hsa-miR-637 hsa-miR-149 hsa-miR-130b hsa-miR-1290 hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: S1PR2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S1PR2 (see all 4)
    OriGene shRNA RFP: S1PR2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat S1PR2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S1PR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S1PR2

    Additional cDNA sequence: 

    AF034780.1 BC069598.1 

    2 DOTS entries:

    DT.213753  DT.436424 

    24/307 AceView cDNA sequences (see all 307):

    BU581157 CD674537 BM680361 BX379257 AW182856 BE694052 BU429780 NM_001379 
    T29495 BF037423 AU130388 AW272197 AW505245 BU431742 AI421186 BX405397 
    BU181438 CA487223 X63692 BU931387 BQ012844 BQ012349 CR623729 BM456185 

    GeneLoc Exon Structure


    Expression
    for S1PR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S1PR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    S1PR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsExtraembryonic AngioblastsEndothelium
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for S1PR2

    SOURCE GeneReport for Unigene cluster: Hs.655405
        SABiosciences Expression via Pathway-Focused PCR Arrays including S1PR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for S1PR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR2 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia S1pr21 , 5 sphingosine-1-phosphate receptor 21, 5 83.33(n)1
    90.91(a)1    		   9 (7.68 cM)5
    147391  NM_010333.41  NP_034463.21 
     209659525 
    chicken
    (Gallus gallus)    		 Aves LOC1008579761 sphingosine 1-phosphate receptor 2-like 70.8(n)
    65.19(a)    		   100857976  XM_003643545.1  XP_003643593.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii edg52 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 less 74.65(n)   170457  AF260256.1 


    ENSEMBL Gene Tree for S1PR2 (if available)
    TreeFam Gene Tree for S1PR2 (if available) 

    Paralogs
    for S1PR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for S1PR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 NCBI SNPs in S1PR2 are shown (see all 246)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs754305931,2
    		--10331621(+) GCTTGA/CTCTCT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1388715991,2
    		--10331944(+) CCTCTC/GTTTTC 1 -- ds50010--------
    rs1917603151,2
    		--10332032(+) GCCCCA/CCTCCT 1 -- ds50010--------
    rs1850818771,2
    		--10332101(+) ACCAAA/CCACAG 1 -- ds50010--------
    rs1494047551,2
    		--10332124(+) GAACCA/GTTTAT 1 -- ut310--------
    rs1437902251,2
    		--10332137(+) GCCTAA/GGTCTG 1 -- ut310--------
    rs794810921,2
    		--10332217(+) GCCCCC/GCAAAG 1 -- ut310--------
    rs730151221,2
    		--10332257(+) GAAATG/TACTCT 1 -- ut310--------
    rs1153212771,2
    		F,--10332456(+) ATCACG/ACCTAT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1473462491,2
    		--10332470(+) CACACA/GCGCGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for S1PR2 (10332109 - 10341948 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for S1PR2
         1 CNV: 5085

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    Disorders / Diseases
    for S1PR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    S1PR2 for disorders           About GeneDecksing

    OMIM gene information: 605111    OMIM disorders: --

    20/21 diseases for S1PR2 (see all 21):    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    pulmonary edema    wilms tumor
    multiple myeloma    embryonal carcinoma    gout    breast cancer
    myeloma    glioblastoma    pertussis    esophageal cancer
    esophagitis    ovarian cancer    breast carcinoma    atherosclerosis
    fibrosis    carcinoma    cerebritis    hepatitis

    4 Novoseek disease relationships for S1PR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 56.5 1 15867375 (1)
    glioma 45.7 4 11146117 (3), 19810093 (1)
    tumors 5.69 1 19903857 (1)
    breast cancer 0 1 10493533 (1)

    Human Genome Epidemiology (HuGE) Navigator: S1PR2 (1 document)

    Export disorders for S1PR2 gene to outside databases

    Publications
    for S1PR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S1PR2 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with S1PR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PubMed id 10617617)1, 2, 9 An S.... Bleu T. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PubMed id 8878560)1, 3 Yamaguchi F.... Brenner S. (1996)
    4. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. (PubMed id 8087418)1, 3 MacLennan A.J....Shaw G. (1994)
    5. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. (PubMed id 18922980)1, 9 Li M.H....Ferrer F. (2008)
    6. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. (PubMed id 9988698)1, 9 Van Brocklyn J.R....Spiegel S. (1999)
    7. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)1, 9 Ancellin N. and Hla T. (1999)
    8. Targeted disruption of the S1P2 sphingosine 1-phospha te receptor gene leads to diffuse large B-cell lymphoma formation. (PubMed id 19903857)1, 9 Cattoretti G....MacLennan A.J. (2009)
    9. Cell type-specific localization of human cardiac S1P receptors. (PubMed id 11967277)1, 9 Mazurais D....Calmels T. (2002)
    10. Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. (PubMed id 12445827)1, 9 Osada M....Ozaki Y. (2002)

    External Searches for S1PR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing S1PR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9294 HGNC: 3169 AceView: EDG5 Ensembl:ENSG00000175898 euGenes: HUgn9294
    ECgene: S1PR2 Kegg: 9294 H-InvDB: S1PR2

    Other Databases showing S1PR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing S1PR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S1PR2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for S1PR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for S1PR2 gene:
    Search GeneIP for patents involving S1PR2

    GeneCards and IP:
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