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Aliases for S1PR2 Gene

Aliases for S1PR2 Gene

  • Sphingosine-1-Phosphate Receptor 2 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
  • Sphingosine 1-Phosphate Receptor Edg-5 3 4
  • Deafness, Autosomal Recessive 68 2 3
  • S1P Receptor Edg-5 3 4
  • S1P Receptor 2 3 4
  • EDG5 3 4
  • S1P2 3 4
  • Sphingosine 1-Phosphate Receptor 2 3
  • S1P Receptor EDG5 3
  • CTD-2369P2.2 3
  • Gpcr13 3
  • DFNB68 3
  • AGR16 3
  • EDG-5 3
  • H218 3
  • LPB2 3

External Ids for S1PR2 Gene

Previous HGNC Symbols for S1PR2 Gene

  • EDG5
  • DFNB68

Previous GeneCards Identifiers for S1PR2 Gene

  • GC19M010332
  • GC19M009912

Summaries for S1PR2 Gene

Entrez Gene Summary for S1PR2 Gene

  • This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

GeneCards Summary for S1PR2 Gene

S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Lysosphingolipid and LPA receptors and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.

UniProtKB/Swiss-Prot for S1PR2 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Tocris Summary for S1PR2 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR2 Gene

Genomics for S1PR2 Gene

Regulatory Elements for S1PR2 Gene

Enhancers for S1PR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010285 1.7 Ensembl ENCODE dbSUPER 10.1 -57.9 -57885 7.6 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF559 RAVER1 LOC100419831 ZNF699 FBXL12 ZNF561 ICAM5 EIF3G ZNF177 ILF3-AS1
GH19G010717 1.7 FANTOM5 ENCODE dbSUPER 10 -487.3 -487349 3.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 EIF3G FBXL12 RAVER1 QTRT1 ZNF627 ILF3-AS1 LOC100419831 SLC44A2 PRKCSH SWSAP1
GH19G010757 1.6 Ensembl ENCODE dbSUPER 9.9 -530.9 -530902 9.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 RAVER1 FBXL12 ZNF627 EIF3G TIMM29 PRKCSH MIR199A1 SLC44A2 MIR638 DNM2
GH19G010870 1.6 FANTOM5 ENCODE dbSUPER 9.9 -640.2 -640201 3.1 HDGF ARNT DMAP1 ZNF2 ZNF143 SP3 SP5 KAT8 ZNF610 SMARCA4 RAVER1 ZNF491 ZNF441 PRKCSH ZNF439 EIF3G ZNF627 SWSAP1 SMARCA4 S1PR2
GH19G010267 1.4 ENCODE dbSUPER 10.2 -38.5 -38531 5.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZNF699 FBXL12 LOC100419831 ZNF559 ZNF561 ZNF846 RAVER1 ZNF562 TIMM29 EIF3G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S1PR2 on UCSC Golden Path with GeneCards custom track

Promoters for S1PR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106973 907 1801 ATF1 AGO1 WRNIP1 ARID4B BRCA1 GLIS2 KDM4B ZNF263 SP3 SP5

Genomic Location for S1PR2 Gene

Chromosome:
19
Start:
10,221,433 bp from pter
End:
10,231,807 bp from pter
Size:
10,375 bases
Orientation:
Minus strand

Genomic View for S1PR2 Gene

Genes around S1PR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR2 Gene

Proteins for S1PR2 Gene

  • Protein details for S1PR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95136-S1PR2_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 2
    Protein Accession:
    O95136
    Secondary Accessions:
    • Q86UN8

    Protein attributes for S1PR2 Gene

    Size:
    353 amino acids
    Molecular mass:
    38867 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S1PR2 Gene

neXtProt entry for S1PR2 Gene

Post-translational modifications for S1PR2 Gene

  • Glycosylation at Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S1PR2 Gene

Domains & Families for S1PR2 Gene

Suggested Antigen Peptide Sequences for S1PR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95136

UniProtKB/Swiss-Prot:

S1PR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR2: view

Function for S1PR2 Gene

Molecular function for S1PR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Gene Ontology (GO) - Molecular Function for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 24851274
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 8087418
GO:0005178 integrin binding IPI 24851274
GO:0005515 protein binding IPI 24851274
genes like me logo Genes that share ontologies with S1PR2: view
genes like me logo Genes that share phenotypes with S1PR2: view

Human Phenotype Ontology for S1PR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for S1PR2 Gene

MGI Knock Outs for S1PR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for S1PR2

CRISPR Products

miRNA for S1PR2 Gene

miRTarBase miRNAs that target S1PR2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for S1PR2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for S1PR2 Gene

Localization for S1PR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S1PR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with S1PR2: view

Pathways & Interactions for S1PR2 Gene

genes like me logo Genes that share pathways with S1PR2: view

SIGNOR curated interactions for S1PR2 Gene

Activates:

Gene Ontology (GO) - Biological Process for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10617617
GO:0003376 sphingosine-1-phosphate signaling pathway IMP 23106337
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10617617
GO:0008284 positive regulation of cell proliferation TAS 10617617
genes like me logo Genes that share ontologies with S1PR2: view

Drugs & Compounds for S1PR2 Gene

(21) Drugs for S1PR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
CYM 5442 hydrochloride Pharma Selective S1P1 receptor agonist 0
JTE 013 Pharma S1P2 receptor antagonist 0
W146 Pharma Antagonist Potent and selective S1P1 receptor antagonist 0
JTE-013 Pharma Antagonist 0

(2) Additional Compounds for S1PR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for S1PR2 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
JTE 013 S1P2 receptor antagonist 547756-93-4
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
VPC 23019 S1P1 and S1P3 antagonist 449173-19-7
W146 Potent and selective S1P1 receptor antagonist 909725-61-7

(14) ApexBio Compounds for S1PR2 Gene

Compound Action Cas Number
BAF312 (Siponimod) S1P agonist,potent and selective 1230487-00-9
CS 2100 913827-99-3
CYM 50260 1355026-60-6
CYM 50308 1345858-76-5
CYM 50358 hydrochloride
CYM 5442 hydrochloride 1094042-01-9
CYM 5541 945128-26-7
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
JTE 013 547756-93-4
N,N-Dimethylsphingosine 119567-63-4
RP 001 hydrochloride 1306761-53-4
SEW 2871 256414-75-2
TC-G 1006 1324003-64-6
W146 909725-61-7
genes like me logo Genes that share compounds with S1PR2: view

Transcripts for S1PR2 Gene

mRNA/cDNA for S1PR2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(307) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S1PR2 Gene

Sphingosine-1-phosphate receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for S1PR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR2 Gene

No ASD Table

Relevant External Links for S1PR2 Gene

GeneLoc Exon Structure for
S1PR2
ECgene alternative splicing isoforms for
S1PR2

Expression for S1PR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S1PR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR2 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for S1PR2 Gene

This gene is overexpressed in Gallbladder (29.6), Placenta (16.9), Pancreas (7.5), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S1PR2 Gene



Protein tissue co-expression partners for S1PR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of S1PR2 Gene:

S1PR2

SOURCE GeneReport for Unigene cluster for S1PR2 Gene:

Hs.655405

Evidence on tissue expression from TISSUES for S1PR2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with S1PR2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR2 Gene

Orthologs for S1PR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR2 34 35
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia S1PR2 34 35
  • 87.41 (n)
dog
(Canis familiaris)
Mammalia S1PR2 34
  • 86.17 (n)
mouse
(Mus musculus)
Mammalia S1pr2 34 16 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia S1pr2 34
  • 82.48 (n)
oppossum
(Monodelphis domestica)
Mammalia S1PR2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR2 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves S1PR2 34
  • 69.49 (n)
lizard
(Anolis carolinensis)
Reptilia S1PR2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr2 34
  • 63.39 (n)
zebrafish
(Danio rerio)
Actinopterygii s1pr2 34 35
  • 64.13 (n)
edg5 34
Species where no ortholog for S1PR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR2 Gene

ENSEMBL:
Gene Tree for S1PR2 (if available)
TreeFam:
Gene Tree for S1PR2 (if available)

Paralogs for S1PR2 Gene

Paralogs for S1PR2 Gene

(10) SIMAP similar genes for S1PR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR2: view

Variants for S1PR2 Gene

Sequence variations from dbSNP and Humsavar for S1PR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_076391 Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419]
VAR_076392 Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419]
rs869312749 Pathogenic 10,224,583(-) TGCCC(C/G)GGAGG reference, missense
rs869312750 Pathogenic 10,224,487(-) GCTGT(A/G)TGGCA reference, missense
rs1001005824 -- 10,229,566(+) ATTAC(A/G)GGCGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S1PR2 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for S1PR2 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S1PR2 Gene

Human Gene Mutation Database (HGMD)
S1PR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
S1PR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR2 Gene

Disorders for S1PR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for S1PR2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 68
  • autosomal recessive nonsyndromic deafness 68
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
deafness, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
Search S1PR2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

S1PR2_HUMAN
  • Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:26805784}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for S1PR2

Genetic Association Database (GAD)
S1PR2
Human Genome Epidemiology (HuGE) Navigator
S1PR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S1PR2
genes like me logo Genes that share disorders with S1PR2: view

No data available for Genatlas for S1PR2 Gene

Publications for S1PR2 Gene

  1. Autosomal-recessive hearing impairment due to rare missense variants within S1PR2. (PMID: 26805784) Santos-Cortez R.L. … Leal S.M. (Am. J. Hum. Genet. 2016) 2 3 4 64
  2. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S. … Bleu T. (J. Biol. Chem. 2000) 3 4 22 64
  3. Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. (PMID: 20194630) Oskeritzian C.A. … Spiegel S. (J. Exp. Med. 2010) 3 22 64
  4. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M. … Ramoni M.F. (Circulation 2009) 3 46 64
  5. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. (PMID: 19903857) Cattoretti G. … MacLennan A.J. (Cancer Res. 2009) 3 22 64

Products for S1PR2 Gene

Sources for S1PR2 Gene

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