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Aliases for S1PR2 Gene

Aliases for S1PR2 Gene

  • Sphingosine-1-Phosphate Receptor 2 2 3
  • EDG5 3 4 6
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
  • Sphingosine 1-Phosphate Receptor Edg-5 3 4
  • S1P Receptor Edg-5 3 4
  • S1P Receptor 2 3 4
  • S1P2 3 4
  • Sphingosine 1-Phosphate Receptor 2 3
  • S1P Receptor EDG5 3
  • Gpcr13 3
  • AGR16 3
  • EDG-5 3
  • H218 3
  • LPB2 3

External Ids for S1PR2 Gene

Previous HGNC Symbols for S1PR2 Gene

  • EDG5

Previous GeneCards Identifiers for S1PR2 Gene

  • GC19M010332
  • GC19M009912

Summaries for S1PR2 Gene

Entrez Gene Summary for S1PR2 Gene

  • This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR2 Gene

S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR2 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

Tocris Summary for S1PR2 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR2 Gene

Genomics for S1PR2 Gene

Regulatory Elements for S1PR2 Gene

Genomic Location for S1PR2 Gene

Start:
10,221,433 bp from pter
End:
10,231,272 bp from pter
Size:
9,840 bases
Orientation:
Minus strand

Genomic View for S1PR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S1PR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR2 Gene

Proteins for S1PR2 Gene

  • Protein details for S1PR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95136-S1PR2_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 2
    Protein Accession:
    O95136
    Secondary Accessions:
    • Q86UN8

    Protein attributes for S1PR2 Gene

    Size:
    353 amino acids
    Molecular mass:
    38867 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S1PR2 Gene

neXtProt entry for S1PR2 Gene

Proteomics data for S1PR2 Gene at MOPED

Post-translational modifications for S1PR2 Gene

  • Glycosylation at Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR2 Gene

Domains for S1PR2 Gene

Gene Families for S1PR2 Gene

HGNC:
  • S1PR :GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate
IUPHAR :

Suggested Antigen Peptide Sequences for S1PR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95136

UniProtKB/Swiss-Prot:

S1PR2_HUMAN :
  • O95136
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR2: view

Function for S1PR2 Gene

Molecular function for S1PR2 Gene

UniProtKB/Swiss-Prot Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

Gene Ontology (GO) - Molecular Function for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 24851274
GO:0004930 G-protein coupled receptor activity TAS 8087418
GO:0005178 integrin binding IPI 24851274
GO:0005515 protein binding IPI 24851274
GO:0008289 lipid binding TAS 10617617
genes like me logo Genes that share ontologies with S1PR2: view
genes like me logo Genes that share phenotypes with S1PR2: view

Animal Models for S1PR2 Gene

MGI Knock Outs for S1PR2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for S1PR2 Gene

Localization for S1PR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR2 Gene COMPARTMENTS Subcellular localization image for S1PR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with S1PR2: view

Pathways for S1PR2 Gene

genes like me logo Genes that share pathways with S1PR2: view

Gene Ontology (GO) - Biological Process for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10617617
GO:0003376 sphingosine-1-phosphate signaling pathway IMP 23106337
GO:0007186 G-protein coupled receptor signaling pathway TAS 10617617
GO:0008284 positive regulation of cell proliferation TAS 10617617
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP 23106337
genes like me logo Genes that share ontologies with S1PR2: view

Compounds for S1PR2 Gene

(5) Tocris Compounds for S1PR2 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist [1094042-01-9]
JTE 013 S1P2 receptor antagonist [547756-93-4]
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 [26993-30-6]
VPC 23019 S1P1 and S1P3 antagonist [449173-19-7]
W146 Potent and selective S1P1 receptor antagonist [909725-61-7]

(1) HMDB Compounds for S1PR2 Gene

Compound Synonyms Cas Number PubMed IDs
Sphingosine
  • (-)-D-erythro-Sphingosine
123-78-4

(2) IUPHAR Ligand for S1PR2 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
JTE-013 Antagonist Antagonist 7.77

(5) Novoseek inferred chemical compound relationships for S1PR2 Gene

Compound -log(P) Hits PubMed IDs
sphinganine 1-phosphate 90.9 1
sphingosylphosphorylcholine 87.2 4
sphingosine 84.6 2
lysophospholipid 84.2 1
calcium 13.9 10
genes like me logo Genes that share compounds with S1PR2: view

Transcripts for S1PR2 Gene

mRNA/cDNA for S1PR2 Gene

(307) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S1PR2 Gene

Sphingosine-1-phosphate receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR2 Gene

No ASD Table

Relevant External Links for S1PR2 Gene

GeneLoc Exon Structure for
S1PR2
ECgene alternative splicing isoforms for
S1PR2

Expression for S1PR2 Gene

mRNA expression in normal human tissues for S1PR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR2 Gene

This gene is overexpressed in Testis (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for S1PR2 Gene

SOURCE GeneReport for Unigene cluster for S1PR2 Gene Hs.655405

genes like me logo Genes that share expressions with S1PR2: view

No data available for mRNA Expression by UniProt/SwissProt for S1PR2 Gene

Orthologs for S1PR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR2 35
  • 99.34 (n)
  • 99.15 (a)
S1PR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S1PR2 35
  • 87.41 (n)
  • 88.64 (a)
S1PR2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR2 35
  • 86.17 (n)
  • 89.77 (a)
mouse
(Mus musculus)
Mammalia S1pr2 35
  • 83.33 (n)
  • 90.91 (a)
S1pr2 16
S1pr2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S1PR2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR2 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr2 35
  • 82.48 (n)
  • 90.34 (a)
chicken
(Gallus gallus)
Aves S1PR2 35
  • 69.49 (n)
  • 62.87 (a)
lizard
(Anolis carolinensis)
Reptilia S1PR2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr2 35
  • 63.39 (n)
  • 63.87 (a)
zebrafish
(Danio rerio)
Actinopterygii edg5 35
s1pr2 35
  • 64.13 (n)
  • 61.9 (a)
s1pr2 36
  • 54 (a)
OneToOne
Species with no ortholog for S1PR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR2 Gene

ENSEMBL:
Gene Tree for S1PR2 (if available)
TreeFam:
Gene Tree for S1PR2 (if available)

Paralogs for S1PR2 Gene

Selected SIMAP similar genes for S1PR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR2: view

Variants for S1PR2 Gene

Sequence variations from dbSNP and Humsavar for S1PR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs968229 -- 10,232,356(-) acaca(C/T)aTCAT upstream-variant-2KB
rs2116941 -- 10,223,767(+) CCCCA(A/C)GTCTC utr-variant-3-prime
rs2116942 -- 10,223,987(+) CGGCC(G/T)CCAGC reference, synonymous-codon
rs3745268 -- 10,224,727(-) GGCCC(A/G)AAACA missense, reference
rs4804496 -- 10,228,088(+) CTGAG(A/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S1PR2 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
nsv911029 CNV Loss 21882294

Relevant External Links for S1PR2 Gene

HapMap Linkage Disequilibrium report
S1PR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR2 Gene

Disorders for S1PR2 Gene

(4) Novoseek inferred disease relationships for S1PR2 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 56.5 1
glioma 45.7 4
tumors 5.69 1
breast cancer 0 1

Relevant External Links for S1PR2

Genetic Association Database (GAD)
S1PR2
Human Genome Epidemiology (HuGE) Navigator
S1PR2
genes like me logo Genes that share disorders with S1PR2: view

No data available for UniProtKB/Swiss-Prot for S1PR2 Gene

Publications for S1PR2 Gene

  1. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S. … Bleu T. (J. Biol. Chem. 2000) 3 4 23
  2. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. (PMID: 9988698) Van Brocklyn J.R. … Spiegel S. (J. Biol. Chem. 1999) 3 23
  3. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PMID: 10383399) Ancellin N. … Hla T. (J. Biol. Chem. 1999) 3 23
  4. The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. (PMID: 15208267) Kaneider N.C. … Wiedermann C.J. (FASEB J. 2004) 3 23
  5. Cell type-specific localization of human cardiac S1P receptors. (PMID: 11967277) Mazurais D. … Calmels T. (J. Histochem. Cytochem. 2002) 3 23

Products for S1PR2 Gene

Sources for S1PR2 Gene

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