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S1PR2 Gene

protein-coding   GIFtS: 55
GCID: GC19M010332

Sphingosine-1-Phosphate Receptor 2

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Receptor 21 2     AGR162
EDG51 2 3 5     EDG-52
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 51 2     Gpcr132
Endothelial Differentiation G-Protein Coupled Receptor 52 3     H2182
Sphingosine 1-Phosphate Receptor Edg-52 3     LPB22
S1P22 3     S1P Receptor EDG52
S1P Receptor 22 3     Sphingosine 1-Phosphate Receptor 22
S1P Receptor Edg-52 3     

External Ids:    HGNC: 31691   Entrez Gene: 92942   Ensembl: ENSG000002675347   OMIM: 6051115   UniProtKB: O951363   

Export aliases for S1PR2 gene to outside databases

Previous GC identifers: GC19M010193 GC19M009912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S1PR2 Gene:
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein
participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation
(provided by RefSeq, Jul 2008)

GeneCards Summary for S1PR2 Gene:
S1PR2 (sphingosine-1-phosphate receptor 2) is a protein-coding gene. Diseases associated with S1PR2 include pulmonary edema, and abdominal aortic aneurysm. GO annotations related to this gene include sphingosine-1-phosphate receptor activity and G-protein coupled receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma
cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

summary for S1PR2 Gene:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the S1PR2 gene promoter:
         MyoD   NF-kappaB   AP-2gamma   C/EBPalpha   CREB   RORalpha1   Ik-2   Zic1   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS1PR2 promoter sequence
   Search Chromatin IP Primers for S1PR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S1PR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19q13

S1PR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010332:  view genomic region     (about GC identifiers)

Start:
10,332,109 bp from pter      End:
10,341,948 bp from pter
Size:
9,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 2  
Size: 353 amino acids; 38867 Da
1 PDB 3D structure from and Proteopedia for S1PR2:
1ZTI (3D)    
Secondary accessions: Q86UN8

Explore the universe of human proteins at neXtProt for S1PR2: NX_O95136

Explore proteomics data for S1PR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn19
  • Modification sites at PhosphoSitePlus

  • See S1PR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004221.3  
    ENSEMBL proteins: 
     ENSP00000466933  
    Reactome Protein details: O95136

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    S1PR: GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

    IUPHAR Guide to PHARMACOLOGY protein family classification: S1P2 receptor
    Lysophospholipid (S1P) receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004063 EDG5_rcpt
     IPR004061 S1P_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O95136

    ProtoNet protein and cluster: O95136

    2 Blocks protein domains:
    IPB004061 Sphingosine 1-phosphate receptor family signature
    IPB004063 EDG-5 sphingosine 1-phosphate receptor signature


    UniProtKB/Swiss-Prot: S1PR2_HUMAN, O95136
    Similarity: Belongs to the G-protein coupled receptor 1 family


    S1PR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S1PR2_HUMAN, O95136
    Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
    that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma
    cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8087418
    GO:0008289lipid binding TAS10617617
    GO:0038036sphingosine-1-phosphate receptor activity IEA--
         
    S1PR2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for S1PR2:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for S1pr2):
     behavior/neurological  cardiovascular system  cellular  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     pigmentation  reproductive system  tumorigenesis 

    S1PR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for S1PR2: S1pr2tm1Jch S1pr2tm1Rlp S1pr2tm1Ytak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S1PR2
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    SwitchGear 3'UTR luciferase reporter plasmidS1PR2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S1PR2_HUMAN, O95136: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    S1PR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S1PR2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3S1P3 pathway
    S1P3 pathway0.44
    Sphingosine 1-phosphate (S1P) pathway0.40
    S1P2 pathway0.44
    4Eicosanoid ligand-binding receptors
    Small Ligand GPCRs0.31
    5Signal Transduction of S1P Receptor
    Signal Transduction of S1P Receptor

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for S1PR2
        Ceramide Pathway
    S-1P Stimulated Signaling
    eNOS Signaling
    Human Embryonic Stem Cell Pluripotency

    5 BioSystems Pathways for S1PR2
        Signal Transduction of S1P Receptor
    Sphingosine 1-phosphate (S1P) pathway
    S1P3 pathway
    S1P2 pathway
    Small Ligand GPCRs


    2 Reactome Pathways for S1PR2
        Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for S1PR2):
        Neuroactive ligand-receptor interaction


    S1PR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including S1PR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for S1PR2

    3 Interacting proteins for S1PR2 (O951363) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA13Q143443I2D: score=2 
    GNAQP501483I2D: score=2 
    GNAI1P630963I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS10617617
    GO:0007186G-protein coupled receptor signaling pathway TAS10617617
    GO:0007610behavior ----
    GO:0008284positive regulation of cell proliferation TAS10617617
    GO:0090394negative regulation of excitatory postsynaptic membrane potential IEA--

    S1PR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for S1PR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    CYM 5442 hydrochlorideSelective S1P1 receptor agonist[1094042-01-9]
    JTE 013S1P2 receptor antagonist[547756-93-4]
    VPC 23019S1P1 and S1P3 antagonist[449173-19-7]
    W146Potent and selective S1P1 receptor antagonist[909725-62-8]

    1 HMDB Compound for S1PR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--

    2 IUPHAR Ligands for S1PR2 (S1P2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    sphingosine 1-phosphate
    AgonistAgonist8.5411705398
    JTE-013
    AntagonistAntagonist7.7712445827

    5 Novoseek inferred chemical compound relationships for S1PR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphinganine 1-phosphate 90.9 1 10626811 (1)
    sphingosylphosphorylcholine 87.2 5 9854026 (2), 9409733 (1), 10381367 (1)
    sphingosine 84.6 2 10617617 (1), 12445827 (1)
    lysophospholipid 84.2 1 10753843 (1)
    calcium 13.9 14 10220556 (6), 9854026 (3), 10383399 (1)



    S1PR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for S1PR2 gene: 
    NM_004230.3  

    Unigene Cluster for S1PR2:

    Sphingosine-1-phosphate receptor 2
    Hs.655405  [show with all ESTs]
    Unigene Representative Sequence: NM_004230
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000590320
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat S1PR2
      QuantiFast Probe-based Assays in human, mouse, rat S1PR2

    Additional mRNA sequence: 

    AF034780.1 BC069598.1 

    2 DOTS entries:

    DT.213753  DT.436424 

    Selected AceView cDNA sequences (see all 307):

    X63692 BU152910 CD674537 AW338649 BX405397 BU581157 CR623729 AW503302 
    NM_001379 BQ012349 AW505245 AW272197 BU431742 BU931387 CR607451 BU181438 
    AI421186 BE513386 BU429780 AW182856 BE222766 CA487223 BM680361 BM456185 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S1PR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    S1PR2 Expression
    About this image


    S1PR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Angioblasts Embryonic Blood Islands
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Angioblasts Extraembryonic Blood Islands
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Angioblasts Embryonic Blood Islands
    S1PR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S1PR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655405
        Pathway & Disease-focused RT2 Profiler PCR Arrays including S1PR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cardiotoxicity in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S1pr21 , 5 sphingosine-1-phosphate receptor 21, 5 83.33(n)1
    90.91(a)1
      9 (7.68 cM)5
    147391  NM_010333.41  NP_034463.21 
     209659525 
    chicken
    (Gallus gallus)
    Aves S1PR21 sphingosine-1-phosphate receptor 2 69.49(n)
    62.87(a)
      100857976  XM_003643545.2  XP_003643593.2 
    lizard
    (Anolis carolinensis)
    Reptilia S1PR26
    sphingosine-1-phosphate receptor 2
    63(a)
    1 ↔ 1
    GL343414.1(847302-848354)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia s1pr21 sphingosine-1-phosphate receptor 2 63.39(n)
    63.87(a)
      100497836  XM_004918817.1  XP_004918874.1 
    zebrafish
    (Danio rerio)
    Actinopterygii edg52 endothelial differentiation, sphingolipid G-protein-coupled more 74.65(n)   170457  AF260256.1 


    ENSEMBL Gene Tree for S1PR2 (if available)
    TreeFam Gene Tree for S1PR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S1PR2 gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR32  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    10 SIMAP similar genes for S1PR2 using alignment to 1 protein entry:     S1PR2_HUMAN:
    EDG1    S1PR1    S1PR3    S1PR5    S1PR4    LPAR3
    LPAR1    EDG2    GPR3    LPAR2

    S1PR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S1PR2 (see all 231)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754305931,2
    F--10331621(+) GCTTGA/CTCTCT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1388715991,2
    --10331944(+) CCTCTC/GTTTTC 1 -- ds50010--------
    rs1917603151,2
    --10332032(+) GCCCCA/CCTCCT 1 -- ds50010--------
    rs1850818771,2
    --10332101(+) ACCAAA/CCACAG 1 -- ds50010--------
    rs1494047551,2
    --10332124(+) GAACCA/GTTTAT 1 -- ut310--------
    rs1437902251,2
    C--10332137(+) GCCTAA/GGTCTG 1 -- ut310--------
    rs794810921,2
    F--10332217(+) GCCCCC/GCAAAG 1 -- ut310--------
    rs730151221,2
    --10332257(+) GAAATG/TACTCT 1 -- ut310--------
    rs1153212771,2
    C,F--10332456(+) ATCACG/ACCTAT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1473462491,2
    C--10332470(+) CACACA/GCGCGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for S1PR2 (10332109 - 10341948 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for S1PR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911029CNV Loss21882294
    nsv833743CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S1PR2
    DNA2.0 Custom Variant and Variant Library Synthesis for S1PR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605111    OMIM disorders: --

    Selected diseases for S1PR2 (see all 21):    
    About MalaCards
    pulmonary edema    abdominal aortic aneurysm    endotheliitis    gout
    aortic aneurysm    diffuse large b-cell lymphoma    pertussis    esophageal cancer
    b-cell lymphomas    wilms tumor    thyroid cancer    glioblastoma multiforme
    multiple myeloma    myeloma    esophagitis    atherosclerosis
    thyroiditis    cerebritis    ovarian cancer    breast cancer


    S1PR2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for S1PR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 56.5 1 15867375 (1)
    glioma 45.7 4 11146117 (3), 19810093 (1)
    tumors 5.69 1 19903857 (1)
    breast cancer 0 1 10493533 (1)

    Genetic Association Database (GAD): S1PR2
    Human Genome Epidemiology (HuGE) Navigator: S1PR2 (1 document)

    Export disorders for S1PR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S1PR2 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with S1PR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PubMed id 10617617)1, 2, 9 An S.... Bleu T. (J. Biol. Chem. 2000)
    2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PubMed id 8878560)1, 3 Yamaguchi F.... Brenner S. (Biochem. Biophys. Res. Commun. 1996)
    5. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. (PubMed id 8087418)1, 3 MacLennan A.J....Shaw G. (Mol. Cell. Neurosci. 1994)
    6. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. (PubMed id 18922980)1, 9 Li M.H....Ferrer F. (Mol. Cancer Res. 2008)
    7. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. (PubMed id 9988698)1, 9 Van Brocklyn J.R....Spiegel S. (J. Biol. Chem. 1999)
    8. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)1, 9 Ancellin N. and Hla T. (J. Biol. Chem. 1999)
    9. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. (PubMed id 19903857)1, 9 Cattoretti G....MacLennan A.J. (Cancer Res. 2009)
    10. Cell type-specific localization of human cardiac S1P receptors. (PubMed id 11967277)1, 9 Mazurais D....Calmels T. (J. Histochem. Cytochem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9294 HGNC: 3169 AceView: EDG5 Ensembl:ENSG00000267534 euGenes: HUgn9294
    ECgene: S1PR2 Kegg: 9294 H-InvDB: S1PR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S1PR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S1PR2 gene:
    Search GeneIP for patents involving S1PR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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