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Aliases for S1PR2 Gene

Aliases for S1PR2 Gene

  • Sphingosine-1-Phosphate Receptor 2 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
  • Sphingosine 1-Phosphate Receptor Edg-5 3 4
  • S1P Receptor Edg-5 3 4
  • S1P Receptor 2 3 4
  • EDG5 3 4
  • S1P2 3 4
  • S1P Receptor EDG5 3
  • CTD-2369P2.2 3
  • DFNB68 3
  • Gpcr13 3
  • AGR16 3
  • EDG-5 3
  • H218 3
  • LPB2 3

External Ids for S1PR2 Gene

Previous HGNC Symbols for S1PR2 Gene

  • EDG5

Previous GeneCards Identifiers for S1PR2 Gene

  • GC19M010332
  • GC19M009912

Summaries for S1PR2 Gene

Entrez Gene Summary for S1PR2 Gene

  • This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

GeneCards Summary for S1PR2 Gene

S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Peptide ligand-binding receptors and S1P3 pathway. GO annotations related to this gene include G-protein coupled receptor activity and integrin binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR2 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Tocris Summary for S1PR2 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR2 Gene

Genomics for S1PR2 Gene

Regulatory Elements for S1PR2 Gene

Enhancers for S1PR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around S1PR2 on UCSC Golden Path with GeneCards custom track

Promoters for S1PR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S1PR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for S1PR2 Gene

Chromosome:
19
Start:
10,221,433 bp from pter
End:
10,231,807 bp from pter
Size:
10,375 bases
Orientation:
Minus strand

Genomic View for S1PR2 Gene

Genes around S1PR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR2 Gene

Proteins for S1PR2 Gene

  • Protein details for S1PR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95136-S1PR2_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 2
    Protein Accession:
    O95136
    Secondary Accessions:
    • Q86UN8

    Protein attributes for S1PR2 Gene

    Size:
    353 amino acids
    Molecular mass:
    38867 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S1PR2 Gene

neXtProt entry for S1PR2 Gene

Proteomics data for S1PR2 Gene at MOPED

Post-translational modifications for S1PR2 Gene

  • Glycosylation at Asn 19
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S1PR2 Gene

Domains & Families for S1PR2 Gene

Gene Families for S1PR2 Gene

Suggested Antigen Peptide Sequences for S1PR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95136

UniProtKB/Swiss-Prot:

S1PR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR2: view

Function for S1PR2 Gene

Molecular function for S1PR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Gene Ontology (GO) - Molecular Function for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 24851274
GO:0005178 integrin binding IPI 24851274
GO:0008289 lipid binding TAS 10617617
genes like me logo Genes that share ontologies with S1PR2: view
genes like me logo Genes that share phenotypes with S1PR2: view

Animal Models for S1PR2 Gene

MGI Knock Outs for S1PR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for S1PR2

CRISPR Products

miRNA for S1PR2 Gene

miRTarBase miRNAs that target S1PR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR2 Gene

Localization for S1PR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR2 Gene COMPARTMENTS Subcellular localization image for S1PR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for S1PR2 Gene

Pathways & Interactions for S1PR2 Gene

genes like me logo Genes that share pathways with S1PR2: view

SIGNOR curated interactions for S1PR2 Gene

Activates:

Gene Ontology (GO) - Biological Process for S1PR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 10617617
GO:0031532 actin cytoskeleton reorganization IMP 23106337
GO:0046847 filopodium assembly IMP 23106337
GO:1903142 positive regulation of establishment of endothelial barrier IMP 24851274
genes like me logo Genes that share ontologies with S1PR2: view

Drugs & Compounds for S1PR2 Gene

(6) Drugs for S1PR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0
JTE-013 Pharma Antagonist 0
Fingolimod (FTY720) Pharma S1P receptors agonist 0

(6) Additional Compounds for S1PR2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CYM 5442 hydrochloride
1094042-01-9
RP 001 hydrochloride
1306761-53-4
SEW 2871
256414-75-2
TC-SP 14
1257093-40-5

(5) Tocris Compounds for S1PR2 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
RP 001 hydrochloride Potent S1P1 agonist 1306761-53-4
SEW 2871 Cell-permeable, selective S1P1 receptor agonist 256414-75-2
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
TC-SP 14 Potent S1P1 receptor agonist 1257093-40-5

(1) ApexBio Compounds for S1PR2 Gene

Compound Action Cas Number
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
genes like me logo Genes that share compounds with S1PR2: view

Transcripts for S1PR2 Gene

mRNA/cDNA for S1PR2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(307) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S1PR2 Gene

Sphingosine-1-phosphate receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR2 Gene

No ASD Table

Relevant External Links for S1PR2 Gene

GeneLoc Exon Structure for
S1PR2
ECgene alternative splicing isoforms for
S1PR2

Expression for S1PR2 Gene

mRNA expression in normal human tissues for S1PR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR2 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for S1PR2 Gene

This gene is overexpressed in Gallbladder (29.6), Placenta (16.9), Pancreas (7.5), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S1PR2 Gene



SOURCE GeneReport for Unigene cluster for S1PR2 Gene Hs.655405

genes like me logo Genes that share expression patterns with S1PR2: view

Protein tissue co-expression partners for S1PR2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for S1PR2 Gene

Orthologs for S1PR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S1PR2 35
  • 87.41 (n)
  • 88.64 (a)
S1PR2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR2 35
  • 86.17 (n)
  • 89.77 (a)
mouse
(Mus musculus)
Mammalia S1pr2 35
  • 83.33 (n)
  • 90.91 (a)
S1pr2 16
S1pr2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S1PR2 35
  • 99.34 (n)
  • 99.15 (a)
S1PR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr2 35
  • 82.48 (n)
  • 90.34 (a)
oppossum
(Monodelphis domestica)
Mammalia S1PR2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR2 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves S1PR2 35
  • 69.49 (n)
  • 62.87 (a)
lizard
(Anolis carolinensis)
Reptilia S1PR2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr2 35
  • 63.39 (n)
  • 63.87 (a)
zebrafish
(Danio rerio)
Actinopterygii edg5 35
s1pr2 35
  • 64.13 (n)
  • 61.9 (a)
s1pr2 36
  • 54 (a)
OneToOne
Species with no ortholog for S1PR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR2 Gene

ENSEMBL:
Gene Tree for S1PR2 (if available)
TreeFam:
Gene Tree for S1PR2 (if available)

Paralogs for S1PR2 Gene

Paralogs for S1PR2 Gene

(10) SIMAP similar genes for S1PR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR2: view

Variants for S1PR2 Gene

Sequence variations from dbSNP and Humsavar for S1PR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8102623 -- 10,225,439(+) ttgcc(A/C)aggct intron-variant
rs12983528 -- 10,231,335(+) ACAGA(A/G)GGGGG upstream-variant-2KB, utr-variant-5-prime
rs12986385 -- 10,232,943(+) ctcag(A/C/G)ctcct upstream-variant-2KB
rs8104426 -- 10,228,000(+) CTGGA(G/T)AAATA intron-variant
rs968229 -- 10,232,356(-) acaca(C/T)aTCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S1PR2 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
nsv911029 CNV Loss 21882294

Variation tolerance for S1PR2 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for S1PR2 Gene

Disorders for S1PR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for S1PR2 Gene - From: ClinVar and Orphanet

Disorder Aliases PubMed IDs
deafness, autosomal recessive 68
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
- elite association - COSMIC cancer census association via MalaCards
Search S1PR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for S1PR2

Genetic Association Database (GAD)
S1PR2
Human Genome Epidemiology (HuGE) Navigator
S1PR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S1PR2
genes like me logo Genes that share disorders with S1PR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S1PR2 Gene

Publications for S1PR2 Gene

  1. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S. … Bleu T. (J. Biol. Chem. 2000) 3 4 23 67
  2. Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. (PMID: 20194630) Oskeritzian C.A. … Spiegel S. (J. Exp. Med. 2010) 3 23
  3. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. (PMID: 19903857) Cattoretti G. … MacLennan A.J. (Cancer Res. 2009) 3 23
  4. Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha. (PMID: 18658144) Zhao C. … Bourgoin S.G. (J. Lipid Res. 2008) 3 23
  5. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. (PMID: 18922980) Li M.H. … Ferrer F. (Mol. Cancer Res. 2008) 3 23

Products for S1PR2 Gene

Sources for S1PR2 Gene

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