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Aliases for S1PR1 Gene

Aliases for S1PR1 Gene

  • Sphingosine-1-Phosphate Receptor 1 2 3
  • EDG1 3 4 6
  • S1P1 3 4 6
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 1 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 1 3 4
  • Sphingosine 1-Phosphate Receptor Edg-1 3 4
  • S1P Receptor Edg-1 3 4
  • S1P Receptor 1 3 4
  • CHEDG1 3 4
  • Sphingosine 1-Phosphate Receptor EDG1 3
  • Sphingosine 1-Phosphate Receptor 1 3
  • CD363 Antigen 4
  • D1S3362 3
  • CD363 3
  • ECGF1 3
  • EDG-1 3

External Ids for S1PR1 Gene

Previous HGNC Symbols for S1PR1 Gene

  • EDG1

Previous GeneCards Identifiers for S1PR1 Gene

  • GC01P101475
  • GC01P101702
  • GC01P099828

Summaries for S1PR1 Gene

Entrez Gene Summary for S1PR1 Gene

  • The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR1 Gene

S1PR1 (Sphingosine-1-Phosphate Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include G-protein coupled receptor activity and sphingolipid binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR1 Gene

  • G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Tocris Summary for S1PR1 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR1 Gene

Genomics for S1PR1 Gene

Regulatory Elements for S1PR1 Gene

Genomic Location for S1PR1 Gene

Start:
101,236,749 bp from pter
End:
101,241,520 bp from pter
Size:
4,772 bases
Orientation:
Plus strand

Genomic View for S1PR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S1PR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR1 Gene

Proteins for S1PR1 Gene

  • Protein details for S1PR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21453-S1PR1_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 1
    Protein Accession:
    P21453
    Secondary Accessions:
    • D3DT66
    • Q9BYY4
    • Q9NYN8

    Protein attributes for S1PR1 Gene

    Size:
    382 amino acids
    Molecular mass:
    42811 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAI3.

    Three dimensional structures from OCA and Proteopedia for S1PR1 Gene

neXtProt entry for S1PR1 Gene

Proteomics data for S1PR1 Gene at MOPED

Post-translational modifications for S1PR1 Gene

  • S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
  • Glycosylation at Asn30 and Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR1 Gene

Domains for S1PR1 Gene

Gene Families for S1PR1 Gene

HGNC:
  • CD :CD molecules
  • S1PR :GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate
IUPHAR :

Suggested Antigen Peptide Sequences for S1PR1 Gene

Graphical View of Domain Structure for InterPro Entry

P21453

UniProtKB/Swiss-Prot:

S1PR1_HUMAN :
  • P21453
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR1: view

Function for S1PR1 Gene

Molecular function for S1PR1 Gene

UniProtKB/Swiss-Prot Function: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
UniProtKB/Swiss-Prot Induction: By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide

Gene Ontology (GO) - Molecular Function for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 24851274
GO:0004930 G-protein coupled receptor activity TAS 8626678
GO:0038036 sphingosine-1-phosphate receptor activity IDA 22344443
GO:0046625 sphingolipid binding IEA --
genes like me logo Genes that share ontologies with S1PR1: view
genes like me logo Genes that share phenotypes with S1PR1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for S1PR1 Gene

Localization for S1PR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR1 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR1 Gene COMPARTMENTS Subcellular localization image for S1PR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2

Gene Ontology (GO) - Cellular Components for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 22344443
genes like me logo Genes that share ontologies with S1PR1: view

Pathways for S1PR1 Gene

genes like me logo Genes that share pathways with S1PR1: view

Gene Ontology (GO) - Biological Process for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001955 blood vessel maturation ISS --
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis ISS --
GO:0003376 sphingosine-1-phosphate signaling pathway IDA 22344443
GO:0006935 chemotaxis ISS --
genes like me logo Genes that share ontologies with S1PR1: view

Compounds for S1PR1 Gene

(5) Tocris Compounds for S1PR1 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist [1094042-01-9]
JTE 013 S1P2 receptor antagonist [547756-93-4]
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 [26993-30-6]
VPC 23019 S1P1 and S1P3 antagonist [449173-19-7]
W146 Potent and selective S1P1 receptor antagonist [909725-61-7]

(2) HMDB Compounds for S1PR1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Sphingosine
  • (-)-D-erythro-Sphingosine
123-78-4

(10) IUPHAR Ligand for S1PR1 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
AUY954 Agonist Agonist 8.92
CYM-5442 Agonist Agonist 8.91
CYM5181 Agonist Agonist 8.41
AFD(R) Agonist Agonist 8.4
W146 Antagonist Antagonist 7.7
SEW2871 Agonist Agonist 7.54
VPC44116 Antagonist Antagonist 6.52
LPA Agonist Agonist 5.6
compound 26 [PMID:16190743] Agonist Agonist 4.9

(18) Novoseek inferred chemical compound relationships for S1PR1 Gene

Compound -log(P) Hits PubMed IDs
sphinganine 1-phosphate 89.6 3
sphingosine 87.2 9
sphingosylphosphorylcholine 86.5 3
lysophospholipid 86.1 3
spiegel 69.5 1
genes like me logo Genes that share compounds with S1PR1: view

Transcripts for S1PR1 Gene

mRNA/cDNA for S1PR1 Gene

Unigene Clusters for S1PR1 Gene

Sphingosine-1-phosphate receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR1 Gene

No ASD Table

Relevant External Links for S1PR1 Gene

GeneLoc Exon Structure for
S1PR1
ECgene alternative splicing isoforms for
S1PR1

Expression for S1PR1 Gene

mRNA expression in normal human tissues for S1PR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for S1PR1 Gene

SOURCE GeneReport for Unigene cluster for S1PR1 Gene Hs.154210

mRNA Expression by UniProt/SwissProt for S1PR1 Gene

P21453-S1PR1_HUMAN
Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin
genes like me logo Genes that share expressions with S1PR1: view

No data available for mRNA differential expression in normal tissues for S1PR1 Gene

Orthologs for S1PR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR1 35
  • 99.48 (n)
  • 99.48 (a)
S1PR1 36
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S1PR1 35
  • 92.23 (n)
  • 94.24 (a)
S1PR1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR1 35
  • 90.75 (n)
  • 95.03 (a)
S1PR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr1 35
  • 88.13 (n)
  • 94.24 (a)
S1pr1 16
S1pr1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S1PR1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr1 35
  • 87.77 (n)
  • 93.93 (a)
chicken
(Gallus gallus)
Aves S1PR1 35
  • 75.29 (n)
  • 86.13 (a)
S1PR1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S1PR1 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5574 35
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr1 35
  • 69.18 (n)
  • 75.81 (a)
zebrafish
(Danio rerio)
Actinopterygii edg1 35
s1pr1 35
  • 70.79 (n)
  • 72.47 (a)
s1pr1 36
  • 70 (a)
OneToOne
Species with no ortholog for S1PR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR1 Gene

ENSEMBL:
Gene Tree for S1PR1 (if available)
TreeFam:
Gene Tree for S1PR1 (if available)

Paralogs for S1PR1 Gene

Selected SIMAP similar genes for S1PR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR1: view

Variants for S1PR1 Gene

Sequence variations from dbSNP and Humsavar for S1PR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1056840 -- 101,241,054(+) TCTTT(C/G)GCACT utr-variant-3-prime
rs1056841 -- 101,241,083(+) AGAAT(C/G)TTGTG utr-variant-3-prime
rs2295337 -- 101,241,574(+) TTGTG(C/T)AGCTC downstream-variant-500B
rs3737577 -- 101,238,976(-) GCCAA(A/C)CCTGT utr-variant-5-prime
rs3737578 -- 101,238,940(-) ACTCC(A/G)GACGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for S1PR1 Gene

Variant ID Type Subtype PubMed ID
nsv871867 CNV Loss 21882294

Relevant External Links for S1PR1 Gene

HapMap Linkage Disequilibrium report
S1PR1
Human Gene Mutation Database (HGMD)
S1PR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR1 Gene

Disorders for S1PR1 Gene

(2) University of Copenhagen DISEASES for S1PR1 Gene

(10) Novoseek inferred disease relationships for S1PR1 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 38.4 8
glioma 33.1 7
autoimmunity 24.9 1
inflammation 20.8 1
neovascularization 11.6 1

Relevant External Links for S1PR1

Genetic Association Database (GAD)
S1PR1
Human Genome Epidemiology (HuGE) Navigator
S1PR1
genes like me logo Genes that share disorders with S1PR1: view

No data available for UniProtKB/Swiss-Prot for S1PR1 Gene

Publications for S1PR1 Gene

  1. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. (PMID: 2160972) Hla T. … Maciag T. (J. Biol. Chem. 1990) 2 3 4 23
  2. The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. (PMID: 8626678) Lee M.-J. … Hla T. (J. Biol. Chem. 1996) 3 4 23
  3. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PMID: 10383399) Ancellin N. … Hla T. (J. Biol. Chem. 1999) 3 4 23
  4. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. (PMID: 11230698) Hobson J.P. … Spiegel S. (Science 2001) 3 4 23
  5. Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. (PMID: 19286607) Singleton P.A. … Birukov K.G. (Circ. Res. 2009) 3 4 23

Products for S1PR1 Gene

Sources for S1PR1 Gene

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