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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S1PR1 Gene

protein-coding   GIFtS: 65
GCID: GC01P101702

Sphingosine-1-Phosphate Receptor 1

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sphingosine-1-Phosphate Receptor 11 2     S1P Receptor Edg-12 3
EDG11 2 3 5     CD3632
S1P12 3 5     D1S33622
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 11 2     ECGF12
Endothelial Differentiation G-Protein Coupled Receptor 12 3     EDG-12
Sphingosine 1-Phosphate Receptor Edg-12 3     Sphingosine 1-Phosphate Receptor 12
CHEDG12 3     Sphingosine 1-Phosphate Receptor EDG12
S1P Receptor 12 3     CD363 Antigen3

External Ids:    HGNC: 31651   Entrez Gene: 19012   Ensembl: ENSG000001709897   OMIM: 6019745   UniProtKB: P214533   

Export aliases for S1PR1 gene to outside databases

Previous GC identifers: GC01P101475 GC01P099828


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S1PR1 Gene:
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in
endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and
suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of
this receptor induces cell-cell adhesion. (provided by RefSeq, Jul 2008)

GeneCards Summary for S1PR1 Gene: 
S1PR1 (sphingosine-1-phosphate receptor 1) is a protein-coding gene. Diseases associated with S1PR1 include follicular thyroid carcinoma, and lymphoblastic lymphoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and sphingolipid binding. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell
G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial
cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins

summary for S1PR1 Gene:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S1PR1 gene promoter:
         HFH-3   FOXO3   RelA   NF-kappaB   LCR-F1   FOXO3b   FOXL1   FOXI1   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS1PR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for S1PR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S1PR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21

S1PR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P101702:  view genomic region     (about GC identifiers)

Start:
101,702,305 bp from pter      End:
101,707,076 bp from pter
Size:
4,772 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 1  
Size: 382 amino acids; 42811 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for S1PR1:
3V2W (3D)        3V2Y (3D)    
Secondary accessions: D3DT66 Q9BYY4 Q9NYN8

Explore the universe of human proteins at neXtProt for S1PR1: NX_P21453

Explore proteomics data for S1PR1 at MOPED 

Post-translational modifications:

  • UniProtKB: S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular
    loop at the Thr-236 residue
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21453

  • S1PR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    S1PR1 Protein Expression
    REFSEQ proteins: NP_001391.2  
    ENSEMBL proteins: 
     ENSP00000305416  
    Reactome Protein details: P21453
    Human Recombinant Protein Products for S1PR1: 
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for S1PR1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    S1PR1 for ontologies           About GeneDecksing



    S1PR1 Antibody Products: 
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    Assay Products for S1PR1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    S1PR: GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

    IUPHAR Guide to PHARMACOLOGY protein family classification: S1P1 receptor 
    Lysophospholipid (S1P) receptors

    4 InterPro protein domains:
     IPR000987 EDG1_rcpt
     IPR004061 S1P_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21453

    ProtoNet protein and cluster: P21453

    2 Blocks protein domains:
    IPB000987 EDG1 orphan receptor signature
    IPB004061 Sphingosine 1-phosphate receptor family signature


    UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
    Similarity: Belongs to the G-protein coupled receptor 1 family


    S1PR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S1PR1_HUMAN, P21453
    Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid
    that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell
    G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial
    cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins
    Induction: By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8626678
    GO:0038036sphingosine-1-phosphate receptor activity IEA--
    GO:0046625sphingolipid binding IEA--
         
    S1PR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for S1PR1:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 8 alleles(MGI details for S1pr1):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging  muscle  nervous system 
     no phenotypic analysis  normal  vision/eye 

    S1PR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for S1PR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for S1PR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for S1PR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S1PR1 

    miRNA
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    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate S1PR1 (see all 70):
    hsa-miR-548j hsa-miR-3146 hsa-miR-106a hsa-miR-3161 hsa-miR-4325 hsa-miR-93 hsa-miR-548a-5p hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidS1PR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: S1PR1 (NM_001400)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for S1PR1
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                         Customized lentivirus expression plasmids for stable overexpression of S1PR1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for S1PR1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3S1P3 pathway
    S1P3 pathway0.44
    Sphingosine 1-phosphate (S1P) pathway0.40
    S1P1 pathway0.41
    4Prostanoid ligand receptors
    Small Ligand GPCRs0.40
    5Signaling events mediated by VEGFR1 and VEGFR2
    Signaling events mediated by VEGFR1 and VEGFR20.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9 BioSystems Pathways for S1PR1 (see all 9)
        Signal Transduction of S1P Receptor
    GPCRs, Other
    Fc-epsilon receptor I signaling in mast cells
    S1P3 pathway
    PDGFR-beta signaling pathway

    5/7        Reactome Pathways for S1PR1 (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    Lysosphingolipid and LPA receptors


    1         Kegg Pathway  (Kegg details for S1PR1):
        Neuroactive ligand-receptor interaction


    S1PR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S1PR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/172 Interacting proteins for S1PR1 (P214533 ENSP000003054164) via UniProtKB, MINT, STRING, and/or I2D (see all 172)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    PDGFRBP096193, ENSP000002617994I2D: score=3 STRING: ENSP00000261799
    AKT1P317493, ENSP000002702024I2D: score=2 STRING: ENSP00000270202
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI3P087543, ENSP000003588674I2D: score=3 STRING: ENSP00000358867
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007155cell adhesion TAS10555146
    GO:0007186G-protein coupled receptor signaling pathway TAS8626678
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007420brain development IEA--

    S1PR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S1PR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for S1PR1

    Compounds for S1PR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    CYM 5442 hydrochlorideSelective S1P1 receptor agonist[1094042-01-9]
    JTE 013S1P2 receptor antagonist[547756-93-4]
    VPC 23019S1P1 and S1P3 antagonist[449173-19-7]
    W146Potent and selective S1P1 receptor antagonist[909725-62-8]

    2 HMDB Compounds for S1PR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--

    10 IUPHAR Ligands for S1PR1 (S1P1 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    compound 26 [PMID:16190743]
    AgonistAgonist9.2216190743
    sphingosine 1-phosphate
    AgonistAgonist7.1 - 9.0511705398 11967257
    AUY954
    AgonistAgonist8.9217114004
    CYM-5442
    AgonistAgonist8.9118708635
    AFD(R)
    AgonistAgonist8.611967257
    CYM5181
    AgonistAgonist8.4118708635
    W146
    AntagonistAntagonist7.716829954
    VPC44116
    AntagonistAntagonist7.5717113298
    SEW2871
    AgonistAgonist7.5418708635
    LPA
    AgonistAgonist5.69705355

    10/18 Novoseek inferred chemical compound relationships for S1PR1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphinganine 1-phosphate 89.6 4 11146117 (2), 9660876 (1)
    sphingosine 87.2 12 11726541 (2), 11230698 (2), 18474015 (1), 18644866 (1) (see all 7)
    sphingosylphosphorylcholine 86.5 5 10833459 (1), 10381367 (1), 9726638 (1)
    lysophospholipid 86.1 4 11604399 (1), 16830220 (1), 16990586 (1)
    spiegel 69.5 1 9705355 (1)
    lipid 40.9 7 10794715 (2), 17156449 (1), 18381082 (1), 16963454 (1) (see all 5)
    lysophosphatidylcholine 33.6 1 20197381 (1)
    ly294002 31.9 1 16195373 (1)
    phosphatidylinositol 23.4 2 15334188 (1), 17403093 (1)
    calcium 20.3 13 9765227 (3), 10383399 (1), 9480864 (1), 9660876 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about S1PR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for S1PR1 gene: 
    NM_001400.4  

    Unigene Cluster for S1PR1:

    Sphingosine-1-phosphate receptor 1
    Hs.154210  [show with all ESTs]
    Unigene Representative Sequence: NM_001400
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305352(uc001dud.2 uc009weg.2) ENST00000475821 ENST00000475289

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S1PR1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S1PR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S1PR1

    Additional mRNA sequence: 

    AF022137.1 AF233365.1 AK297005.1 AK312493.1 BC018650.1 CR541786.1 CR542269.1 

    8 DOTS entries:

    DT.112585  DT.95283317  DT.100662216  DT.100775720  DT.121387197  DT.95122743  DT.95137763  DT.95137764 

    24/105 AceView cDNA sequences (see all 105):

    AW827198 AA304390 BP344454 BM021365 T27666 BQ003555 AI566829 BU681185 
    CK820076 BM354114 BG251038 BM021114 AA370448 BP345893 BQ723639 AW515813 
    AF233365 BX104139 CR541786 F05373 CK429916 CR542269 BU677564 AI636061 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S1PR1 expression in normal human tissues (normalized intensities)      S1PR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTATTTT
    S1PR1 Expression
    About this image


    S1PR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 16 entries
             Umbilical vein endothelial cells Umbilical Veins
             PureStem endothelial progenitor 30-SM2-1
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
             Human Renal Glomerular Endothelial Cells (HRGEC)   
             cd31+ cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             PureStem endothelial progenitor 30-MV2-12
             cd31+ cells   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Angioblasts Embryonic Capillary Plexus
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Juxtaglomerular Cells Afferent Arteriole
             Human Renal Glomerular Endothelial Cells (HRGEC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical vein endothelial cells Umbilical Veins
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   

    See S1PR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S1PR1

    SOURCE GeneReport for Unigene cluster: Hs.154210

    UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
    Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts,
    melanocytes, and cells of epithelioid origin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S1pr11 , 5 sphingosine-1-phosphate receptor 11, 5 88.13(n)1
    94.24(a)1
      3 (50.00 cM)5
    136091  NM_007901.51  NP_031927.21 
     1157104335 
    chicken
    (Gallus gallus)
    Aves S1PR11 sphingosine-1-phosphate receptor 1 75.29(n)
    86.13(a)
      424462  XM_422305.3  XP_422305.2 
    lizard
    (Anolis carolinensis)
    Reptilia S1PR16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    4(87277932-87405993)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55742 Xenopus laevis transcribed sequence with moderate similarity more 76.5(n)    CD361371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii edg12 endothelial differentiation, sphingolipid G-protein-coupled more 78.09(n)   64617  AF321294.1 


    ENSEMBL Gene Tree for S1PR1 (if available)
    TreeFam Gene Tree for S1PR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S1PR1 gene
    CNR12  GPR122  LPAR22  CNR22  S1PR32  S1PR22  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    9 SIMAP similar genes for S1PR1 using alignment to 1 protein entry:     S1PR1_HUMAN:
    EDG1    S1PR3    S1PR2    LPAR1    EDG2    LPAR3
    S1PR4    S1PR5    LPAR2

    S1PR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/304 SNPs in S1PR1 are shown (see all 304)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562364171,2
    --99829696(+) GGGGCG/TCGGGG 1 -- int10--------
    rs353272871,2
    C--101701146(+) TTTTT-/TGGCAA 1 -- us2k10--------
    rs350163881,2
    C--101704233(+) AAAAA-/ATCTCT 1 -- int10--------
    rs120852131,2
    --101704234(+) TTTTTA/TAAAAA 1 -- int10--------
    rs2022388551,2
    C--101707562(+) CATGTG/TTNNNN 1 -- ds50010--------
    rs349572511,2
    C--101707568(+) TTTTT-/G/TG  
            
    TTTTT
    1 -- ds50011NA 2
    rs1140735521,2
    F--101723630(+) TGTTAC/TATGAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs761168081,2
    C,F--101723723(+) TGAGTG/AGTTTT 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs603712311,2
    C,F--101723775(+) ACTTGT/AACAGT 1 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs749543351,2
    --101723811(+) TAAATA/CTAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for S1PR1 (101702305 - 101707076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for S1PR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871867CNV Loss21882294


    Human Gene Mutation Database (HGMD): S1PR1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601974    OMIM disorders: --

    20/31 diseases for S1PR1 (see all 31):    About MalaCards
    follicular thyroid carcinoma    lymphoblastic lymphoma    food allergy    endotheliitis
    lymphopenia    neuritis    gout    sjogren's syndrome
    sinusitis    gingivitis    pertussis    abdominal aortic aneurysm
    vascular disease    vasculitis    aortic aneurysm    diffuse large b-cell lymphoma
    multiple sclerosis    thyroid cancer    thyroiditis    ovarian cancer

    2 diseases from the University of Copenhagen DISEASES database for S1PR1:
    Multiple sclerosis     Lymphopenia

    S1PR1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for S1PR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 38.4 9 19810093 (6), 19937366 (1), 12175535 (1)
    glioma 33.1 7 19810093 (3), 11146117 (3), 19937366 (1)
    autoimmunity 24.9 1 15578083 (1)
    inflammation 20.8 2 18474015 (1)
    neovascularization 11.6 1 15334188 (1)
    sepsis 0 3 15710622 (1), 19278594 (1)
    breast cancer 0 1 10493533 (1)
    ovarian cancer 0 3 17349972 (1), 10818454 (1)
    vascular diseases 0 2 11557736 (1)
    tumors 0 3 19810093 (2), 17203465 (1)

    Genetic Association Database (GAD): S1PR1
    Human Genome Epidemiology (HuGE) Navigator: S1PR1 (8 documents)

    Export disorders for S1PR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S1PR1 gene, integrated from 9 sources (see all 232):
    (articles sorted by number of sources associating them with S1PR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. (PubMed id 2160972)1, 2, 3, 9 Hla T. and Maciag T. (1990)
    2. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (PubMed id 9488656)1, 2, 3 Lee M.J....Hla T. (1998)
    3. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. (PubMed id 11230698)1, 2, 9 Hobson J.P.... Spiegel S. (2001)
    4. The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. (PubMed id 8626678)1, 2, 9 Lee M.-J.... Hla T. (1996)
    5. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)1, 2, 9 Ancellin N. and Hla T. (1999)
    6. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (PubMed id 11583630)1, 2, 9 Lee M.-J.... Hla T. (2001)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Functional variants of the sphingosine-1-phosphate re ceptor 1 gene associate with asthma susceptibility. (PubMed id 20624651)1, 4 Sun X....Garcia J.G. (2010)
    9. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1901 HGNC: 3165 AceView: EDG1 Ensembl:ENSG00000170989 euGenes: HUgn1901
    ECgene: S1PR1 Kegg: 1901 H-InvDB: S1PR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S1PR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for S1PR1 gene:
    Search GeneIP for patents involving S1PR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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