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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

S1PR1 Gene

protein-coding GIFtS: 64
GCID: GC01P101702

sphingosine-1-phosphate receptor 1

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG1)

Explore 27 diseases affiliated with
S1PR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sphingosine-1-Phosphate Receptor 1¹ ²		S1P Receptor 1² ³
EDG1¹ ² ³ ⁵		S1P Receptor Edg-1² ³
S1P1² ³ ⁵		Edg-1¹
CD363¹ ²		ECGF1²
D1S3362¹ ²		EDG-1²
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 1¹ ²		Sphingosine 1-Phosphate Receptor 1²
Endothelial Differentiation G-Protein Coupled Receptor 1² ³		Sphingosine 1-Phosphate Receptor EDG1²
Sphingosine 1-Phosphate Receptor Edg-1² ³		CD363 Antigen³
CHEDG1² ³

External Ids:	HGNC: 3165¹	Entrez Gene: 1901²	Ensembl: ENSG00000170989⁷	OMIM: 601974⁵	UniProtKB: P21453³

Export aliases for S1PR1 gene to outside databases

Previous GC identifers: GC01P101475 GC01P099828

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S1PR1:

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in

endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested

to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor

induces cell-cell adhesion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that

elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell

G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells.

Seems to be coupled to the G(i) subclass of heteromeric G proteins

summary for S1PR1:

Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently

divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of

tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest

density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological

effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal

remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the S1PR1 gene promoter:
HFH-3 FOXO3 RelA NF-kappaB LCR-F1 FOXO3b FOXL1 FOXI1 FOXO3a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S1PR1 promoter sequence

Search SABiosciences Chromatin IP Primers for S1PR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S1PR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p21

S1PR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P101702: view genomic region (about GC identifiers)

Start:	101,702,305 bp from pter	End:	101,707,076 bp from pter
Size:	4,772 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453 (See protein sequence)

Recommended Name: Sphingosine 1-phosphate receptor 1

Size: 382 amino acids; 42811 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

2 PDB 3D structures from and Proteopedia for S1PR1:

3V2W (3D)

3V2Y (3D)

Secondary accessions: D3DT66 Q9BYY4 Q9NYN8

Explore the universe of human proteins at neXtProt for S1PR1: NX_P21453

Post-translational modifications:

S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop

at the Thr-236 residue¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21453

S1PR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001391.2

ENSEMBL proteins:

ENSP00000305416

Reactome Protein details: P21453
Human Recombinant Protein Products for S1PR1:

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	Uscn Proteins for S1PR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

S1PR1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

S1PR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000987 EDG1_rcpt

IPR004061 S1P_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P21453

ProtoNet protein and cluster: P21453

2 Blocks protein families:

IPB000987 EDG1 orphan receptor signature

IPB004061 Sphingosine 1-phosphate receptor family signature

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S1PR1_HUMAN, P21453

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that

elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell

G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells.

Seems to be coupled to the G(i) subclass of heteromeric G proteins

Induction: By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	TAS	8626678
GO:0038036	sphingosine-1-phosphate receptor activity	IEA	--
GO:0046625	sphingolipid binding	IEA	--

S1PR1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for S1PR1:

Decreased focal adhesion (FA)

Increased gamma-H2AX phosphory

13 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for S1pr1):

cardiovascular system	cellular	embryogenesis	hematopoietic system	homeostasis/metabolism
immune system	limbs/digits/tail	mortality/aging	muscle	nervous system
no phenotypic analysis	normal	vision/eye

S1PR1 for phenotypes About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S1PR1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			G alpha (i) signalling events	0.44
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

S1P3 pathway

	S1P3 pathway	1.00			Sphingosine 1-phosphate (S1P) pathway	0.40
	S1P1 pathway	0.41

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Lysosphingolipid and LPA receptors

Lysosphingolipid and LPA receptors

1.00

Signal Transduction of S1P Receptor

Signal Transduction of S1P Receptor

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 BioSystems Pathways for S1PR1 (see all 9)

	Signal Transduction of S1P Receptor
	GPCRs, Other
	Fc-epsilon receptor I signaling in mast cells
	Small Ligand GPCRs
	Signaling events mediated by VEGFR1 and VEGFR2

5/7 Reactome Pathways for S1PR1 (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events
	Lysosphingolipid and LPA receptors

1 Kegg Pathway (Kegg details for S1PR1):

Neuroactive ligand-receptor interaction

S1PR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for S1PR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/172 Interacting proteins for S1PR1 (P21453³ ENSP00000305416⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 172)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAV1	Q03135³, ENSP00000339191⁴	I2D: score=3 STRING: ENSP00000339191
PDGFRB	P09619³, ENSP00000261799⁴	I2D: score=3 STRING: ENSP00000261799
AKT1	P31749³, ENSP00000270202⁴	I2D: score=2 STRING: ENSP00000270202
GNAI1	P63096³, ENSP00000343027⁴	I2D: score=2 STRING: ENSP00000343027
GNAI3	P08754³, ENSP00000358867⁴	I2D: score=3 STRING: ENSP00000358867

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0007155	cell adhesion	TAS	10555146
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8626678
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA	--
GO:0007420	brain development	IEA	--

S1PR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

S1PR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for S1PR1

Compounds for S1PR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
SEW 2871	Cell-permeable, selective S1P1 receptor agonist	[256414-75-2]
Sphingosine-1-phosphate	Endogenous agonist at S1P1-5	[26993-30-6]
RP 001 hydrochloride	Potent S1P1 agonist	[1306761-53-4]
VPC 23019	S1P1 and S1P3 antagonist	[449173-19-7]
TC-SP 14	Potent S1P1 receptor agonist	[1257093-40-5]

2 HMDB Compounds for S1PR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Sphingosine	(-)-D-erythro-Sphingosine (see all 7)	123-78-4	--

10/18 Novoseek chemical compound relationships for S1PR1 gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sphinganine 1-phosphate	89.6	4	11146117 (2), 9660876 (1)
sphingosine	87.2	12	11726541 (2), 11230698 (2), 18474015 (1), 18644866 (1) (see all 7)
sphingosylphosphorylcholine	86.5	5	10833459 (1), 10381367 (1), 9726638 (1)
lysophospholipid	86.1	4	11604399 (1), 16830220 (1), 16990586 (1)
spiegel	69.5	1	9705355 (1)
lipid	40.9	7	10794715 (2), 17156449 (1), 18381082 (1), 16963454 (1) (see all 5)
lysophosphatidylcholine	33.6	1	20197381 (1)
ly294002	31.9	1	16195373 (1)
phosphatidylinositol	23.4	2	15334188 (1), 17403093 (1)
calcium	20.3	13	9765227 (3), 10383399 (1), 9480864 (1), 9660876 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about S1PR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for S1PR1 gene:

NM_001400.4

Unigene Cluster for S1PR1:

Sphingosine-1-phosphate receptor 1

Hs.154210 [show with all ESTs]

Unigene Representative Sequence: NM_001400

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305352(uc001dud.2 uc009weg.2) ENST00000475821 ENST00000475289

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Additional cDNA sequence:

AF022137.1 AF233365.1 AK297005.1 AK312493.1 BC018650.1 CR541786.1 CR542269.1

8 DOTS entries:

DT.112585 DT.95283317 DT.100662216 DT.100775720 DT.121387197 DT.95122743 DT.95137763 DT.95137764

24/105 AceView cDNA sequences (see all 105):

BE710296 T27666 AI636061 F05373 AA304390 BC018650 AI566829 BU677564

AW827198 F01623 CR542269 AA370448 BM021114 BG251038 CK820076 AF233365

BU681185 BQ723639 BQ003555 BP345893 BP344454 BM354114 BM021365 BX104139

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

S1PR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGTATTTT

About this image

S1PR1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Mural Cells

Extraembryonic Tissues

Kidney

Afferent Arteriole

Juxtaglomerular Cells

Kidney, Smooth Muscle

Lateral Plate Mesoderm

Embryonic Blood Islands

Angioblasts

Endothelium

Lateral Plate Mesoderm

Embryonic Capillary Plexus

Angioblasts

Endothelium

Lateral Plate Mesoderm

Paired Dorsal Aorta

Arterial endothelial cells

Endothelium

Lateral Plate Mesoderm

Splanchnic Mesoderm

Mural Cells

Pericytes, Smooth Muscle

Umbilical Cord

Umbilical Veins

Umbilical vein endothelial cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

Posterior foregut-like cells (A scalable, suspensi...)

See S1PR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S1PR1

SOURCE GeneReport for Unigene cluster: Hs.154210

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453

Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts,

melanocytes, and cells of epithelioid origin

SABiosciences Expression via Pathway-Focused PCR Arrays including S1PR1:

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Th17 Response in human mouse rat

Hypertension in human mouse rat

Angiogenesis in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for S1PR1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	S1PR1¹	sphingosine-1-phosphate receptor 1	75.29(n) 86.13(a)		424462 XM_422305.3 XP_422305.2
lizard (Anolis carolinensis)	Reptilia	S1PR1⁶	--	82(a)	1 ↔ 1	4(87280932-87282074)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5574²	Xenopus laevis transcribed sequence with moderate similarity more	76.5(n)		CD361371.1
zebrafish (Danio rerio)	Actinopterygii	edg1²	endothelial differentiation, sphingolipid G-protein-coupled more	78.09(n)		64617 AF321294.1

ENSEMBL Gene Tree for S1PR1 (if available)
TreeFam Gene Tree for S1PR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for S1PR1 gene

CNR1² GPR12² ENSG00000267534² LPAR2² CNR2² S1PR3² MC1R² LPAR1²

MC3R² MC5R² MC2R² GPR3² MC4R² S1PR4² GPR6² LPAR3²

S1PR5²

9 SIMAP similar genes for S1PR1 using alignment to 1 protein entry: S1PR1_HUMAN:

EDG1 S1PR3 S1PR2 LPAR1 EDG2 LPAR3

S1PR4 S1PR5 LPAR2

S1PR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76116808^1,2	F	--	99826626(+)	`TGAGTG/AGTTTT`	1	--	us2k¹		1		NA	120
rs60371231^1,2		--	99826678(+)	`ACTTGT/AACAGT`	1	--	us2k¹		2		CSA WA	120
rs74954335^1,2		--	99826714(+)	`TAAATA/CTAGAA`	1	--	us2k¹		0	--	--	--	--
rs12141562^1,2	C,H	--	99826868(+)	`CCTTAG/ATTGTC`	1	--	us2k¹ tfbs³		4		NS EA	418
rs76416983^1,2	F	--	99826962(+)	`TGCTTG/AATACA`	1	--	us2k¹		1		NA	120
rs13376267^1,2	C,F	--	99827037(+)	`GAGGCG/AGGAGA`	1	--	us2k¹ trp³		1		WA	118
rs17123892^1,2	C,F,H	--	99827074(+)	`TTGTTG/TTGCTG`	1	--	us2k¹		9		NA NS EA CSA WA	674
rs12354250^1,2	H	--	99827355(+)	`TCTGAG/ATCATT`	1	--	us2k¹		4		NS EA	420
rs76482239^1,2	F	--	99827700(+)	`TGGCCG/AAGAAT`	1	--	us2k¹		1		EA	120
rs79060434^1,2	F	--	99827969(+)	`AACCTC/TCCGGT`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for S1PR1 (101702305 - 101707076 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for S1PR1: --
Human Gene Mutation Database (HGMD): S1PR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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S1PR1 for disorders           About GeneDecksing

OMIM gene information: 601974    OMIM disorders: --

20/27 diseases for S1PR1 (see all 27):    About MalaCards

food allergy follicular thyroid carcinoma lymphopenia sjogren's syndrome

neuritis lymphoblastic lymphoma thyroid carcinoma multiple sclerosis

ovarian cancer sepsis gout breast cancer

asthma sinusitis thyroiditis pertussis

gingivitis gastric cancer breast carcinoma carcinoma

2 diseases from the University of Copenhagen DISEASES database for S1PR1:

Multiple sclerosis Lymphopenia

10 Novoseek disease relationships for S1PR1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	38.4	9	19810093 (6), 19937366 (1), 12175535 (1)
glioma	33.1	7	19810093 (3), 11146117 (3), 19937366 (1)
autoimmunity	24.9	1	15578083 (1)
inflammation	20.8	2	18474015 (1)
neovascularization	11.6	1	15334188 (1)
sepsis	0	3	15710622 (1), 19278594 (1)
breast cancer	0	1	10493533 (1)
ovarian cancer	0	3	17349972 (1), 10818454 (1)
vascular diseases	0	2	11557736 (1)
tumors	0	3	19810093 (2), 17203465 (1)

Human Genome Epidemiology (HuGE) Navigator: S1PR1 (8 documents)

Export disorders for S1PR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for S1PR1 gene, integrated from 9 sources (see all 226):
(articles sorted by number of sources associating them with S1PR1)

Utopia: connect your pdf to the dynamic
world of online information

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. (PubMed id 2160972)^{1, 2, 3, 9} Hla T. and Maciag T. (1990)
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (PubMed id 9488656)^{1, 2, 3} Lee M.J....Hla T. (1998)
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. (PubMed id 11230698)^{1, 2, 9} Hobson J.P.... Spiegel S. (2001)
The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. (PubMed id 8626678)^{1, 2, 9} Lee M.-J.... Hla T. (1996)
Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)^{1, 2, 9} Ancellin N. and Hla T. (1999)
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (PubMed id 11583630)^{1, 2, 9} Lee M.-J.... Hla T. (2001)
Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. (PubMed id 10982820)^{1, 2} Parrill A.L.... Tigyi G. (2000)
Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PubMed id 9409733)^{1, 2} An S....Goetzl E.J. (1997)
Sphingosine-1-phosphate receptor type 1 regulates gli oma cell proliferation and correlates with patient survival. (PubMed id 19810093)^{1, 9} Yoshida Y....Hamada J. (2010)
Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. (PubMed id 10921915)^{1, 9} Igarashi J. and Michel T. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1901	HGNC: 3165	AceView: EDG1	Ensembl:ENSG00000170989	euGenes: HUgn1901
ECgene: S1PR1	Kegg: 1901	H-InvDB: S1PR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for S1PR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for S1PR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for S1PR1 gene:
Search GeneIP for patents involving S1PR1

GeneCards and IP:
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S1PR1 Gene

sphingosine-1-phosphate receptor 1

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sphingosine-1-phosphate receptor 1

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