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Aliases for S1PR1 Gene

Aliases for S1PR1 Gene

  • Sphingosine-1-Phosphate Receptor 1 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 1 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 1 3 4
  • Sphingosine 1-Phosphate Receptor Edg-1 3 4
  • S1P Receptor Edg-1 3 4
  • S1P Receptor 1 3 4
  • CHEDG1 3 4
  • EDG1 3 4
  • S1P1 3 4
  • Sphingosine 1-Phosphate Receptor EDG1 3
  • CD363 Antigen 4
  • D1S3362 3
  • CD363 3
  • ECGF1 3
  • EDG-1 3

External Ids for S1PR1 Gene

Previous HGNC Symbols for S1PR1 Gene

  • EDG1

Previous GeneCards Identifiers for S1PR1 Gene

  • GC01P101475
  • GC01P101702
  • GC01P099828

Summaries for S1PR1 Gene

Entrez Gene Summary for S1PR1 Gene

  • The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for S1PR1 Gene

S1PR1 (Sphingosine-1-Phosphate Receptor 1) is a Protein Coding gene. Diseases associated with S1PR1 include autoimmune encephalitis and gallbladder adenocarcinoma. Among its related pathways are Signaling by GPCR and S1P3 pathway. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for S1PR1 Gene

  • G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Tocris Summary for S1PR1 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR1 Gene

Genomics for S1PR1 Gene

Regulatory Elements for S1PR1 Gene

Promoters for S1PR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S1PR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for S1PR1 Gene

Chromosome:
1
Start:
101,236,749 bp from pter
End:
101,241,520 bp from pter
Size:
4,772 bases
Orientation:
Plus strand

Genomic View for S1PR1 Gene

Genes around S1PR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR1 Gene

Proteins for S1PR1 Gene

  • Protein details for S1PR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21453-S1PR1_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 1
    Protein Accession:
    P21453
    Secondary Accessions:
    • D3DT66
    • Q9BYY4
    • Q9NYN8

    Protein attributes for S1PR1 Gene

    Size:
    382 amino acids
    Molecular mass:
    42811 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAI3.

    Three dimensional structures from OCA and Proteopedia for S1PR1 Gene

neXtProt entry for S1PR1 Gene

Proteomics data for S1PR1 Gene at MOPED

Post-translational modifications for S1PR1 Gene

  • S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
  • Glycosylation at Thr 4, Ser 5, Asn 30, and Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S1PR1 Gene

Domains & Families for S1PR1 Gene

Graphical View of Domain Structure for InterPro Entry

P21453

UniProtKB/Swiss-Prot:

S1PR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR1: view

Function for S1PR1 Gene

Molecular function for S1PR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
UniProtKB/Swiss-Prot Induction:
By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide.

Gene Ontology (GO) - Molecular Function for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 24851274
genes like me logo Genes that share ontologies with S1PR1: view
genes like me logo Genes that share phenotypes with S1PR1: view

Animal Models for S1PR1 Gene

MGI Knock Outs for S1PR1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR1 Gene

Localization for S1PR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR1 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S1PR1 Gene COMPARTMENTS Subcellular localization image for S1PR1 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with S1PR1: view

Pathways & Interactions for S1PR1 Gene

genes like me logo Genes that share pathways with S1PR1: view

SIGNOR curated interactions for S1PR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001955 blood vessel maturation IEA,ISS --
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IEA,ISS --
GO:0007155 cell adhesion TAS 9488656
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 8626678
genes like me logo Genes that share ontologies with S1PR1: view

Drugs & Compounds for S1PR1 Gene

(26) Drugs for S1PR1 Gene - From: Novoseek, DGIdb, IUPHAR, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fingolimod Approved, Investigational Pharma modulator 0
Sphingosine Experimental Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0
AFD(R) Pharma Agonist 0
AUY954 Pharma Agonist 0

(14) Additional Compounds for S1PR1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
CYM 5442 hydrochloride
1094042-01-9
RP 001 hydrochloride
1306761-53-4
SEW 2871
256414-75-2
TC-SP 14
1257093-40-5
genes like me logo Genes that share compounds with S1PR1: view

Drug Products

Transcripts for S1PR1 Gene

Unigene Clusters for S1PR1 Gene

Sphingosine-1-phosphate receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR1 Gene

No ASD Table

Relevant External Links for S1PR1 Gene

GeneLoc Exon Structure for
S1PR1
ECgene alternative splicing isoforms for
S1PR1

Expression for S1PR1 Gene

mRNA expression in normal human tissues for S1PR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for S1PR1 Gene

This gene is overexpressed in Pancreatic juice (23.6), Heart (18.1), and Frontal cortex (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S1PR1 Gene



SOURCE GeneReport for Unigene cluster for S1PR1 Gene Hs.154210

mRNA Expression by UniProt/SwissProt for S1PR1 Gene

P21453-S1PR1_HUMAN
Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
genes like me logo Genes that share expression patterns with S1PR1: view

Protein tissue co-expression partners for S1PR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for S1PR1 Gene

Orthologs for S1PR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR1 35
  • 99.48 (n)
  • 99.48 (a)
S1PR1 36
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S1PR1 36
  • 94 (a)
OneToOne
S1PR1 35
  • 92.23 (n)
  • 94.24 (a)
dog
(Canis familiaris)
Mammalia S1PR1 35
  • 90.75 (n)
  • 95.03 (a)
S1PR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr1 16
S1pr1 36
  • 94 (a)
OneToOne
S1pr1 35
  • 88.13 (n)
  • 94.24 (a)
oppossum
(Monodelphis domestica)
Mammalia S1PR1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S1pr1 35
  • 87.77 (n)
  • 93.93 (a)
chicken
(Gallus gallus)
Aves S1PR1 36
  • 85 (a)
OneToOne
S1PR1 35
  • 75.29 (n)
  • 86.13 (a)
lizard
(Anolis carolinensis)
Reptilia S1PR1 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5574 35
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr1 35
  • 69.18 (n)
  • 75.81 (a)
zebrafish
(Danio rerio)
Actinopterygii s1pr1 36
  • 70 (a)
OneToOne
edg1 35
s1pr1 35
  • 70.79 (n)
  • 72.47 (a)
Species with no ortholog for S1PR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR1 Gene

ENSEMBL:
Gene Tree for S1PR1 (if available)
TreeFam:
Gene Tree for S1PR1 (if available)

Paralogs for S1PR1 Gene

Paralogs for S1PR1 Gene

(9) SIMAP similar genes for S1PR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S1PR1: view

Variants for S1PR1 Gene

Sequence variations from dbSNP and Humsavar for S1PR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4987250 - 101,239,028(+) CAGCT(C/G/T)GGTCT reference, missense
rs11542632 - 101,239,327(+) CTCCC(A/G)CCCAG reference, missense
rs7549921 - 101,239,979(+) GTGCC(A/C/G)GAGCG reference, missense
rs1056840 -- 101,241,054(+) TCTTT(C/G)GCACT utr-variant-3-prime
rs1056841 -- 101,241,083(+) AGAAT(C/G)TTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for S1PR1 Gene

Variant ID Type Subtype PubMed ID
nsv871867 CNV Loss 21882294

Variation tolerance for S1PR1 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S1PR1 Gene

HapMap Linkage Disequilibrium report
S1PR1
Human Gene Mutation Database (HGMD)
S1PR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR1 Gene

Disorders for S1PR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for S1PR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autoimmune encephalitis
  • hashimoto's encephalitis
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
demyelinating disease
  • demyelinating disorder
- elite association - COSMIC cancer census association via MalaCards
Search S1PR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for S1PR1

Genetic Association Database (GAD)
S1PR1
Human Genome Epidemiology (HuGE) Navigator
S1PR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S1PR1
genes like me logo Genes that share disorders with S1PR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S1PR1 Gene

Publications for S1PR1 Gene

  1. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. (PMID: 2160972) Hla T. … Maciag T. (J. Biol. Chem. 1990) 2 3 4 23 67
  2. Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival. (PMID: 19810093) Yoshida Y. … Hamada J. (Int. J. Cancer 2010) 3 23
  3. Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma. (PMID: 20081804) Nishimura H. … Sadahira Y. (Mod. Pathol. 2010) 3 23
  4. Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. (PMID: 18936953) Estrada R. … Lee M.J. (Histochem. Cell Biol. 2009) 3 23
  5. Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. (PMID: 19158154) Liao J.J. … Goetzl E.J. (FASEB J. 2009) 3 23

Products for S1PR1 Gene

Sources for S1PR1 Gene

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