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S1PR1 Gene

protein-coding   GIFtS: 65
GCID: GC01P101702

Sphingosine-1-Phosphate Receptor 1

(Previous names: endothelial differentiation, sphingolipid G-protein-coupled...)
(Previous symbol: EDG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Receptor 11 2     S1P Receptor Edg-12 3
EDG11 2 3 5     CD3632
S1P12 3 5     D1S33622
Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 11 2     ECGF12
Endothelial Differentiation G-Protein Coupled Receptor 12 3     EDG-12
Sphingosine 1-Phosphate Receptor Edg-12 3     Sphingosine 1-Phosphate Receptor 12
CHEDG12 3     Sphingosine 1-Phosphate Receptor EDG12
S1P Receptor 12 3     CD363 Antigen3

External Ids:    HGNC: 31651   Entrez Gene: 19012   Ensembl: ENSG000001709897   OMIM: 6019745   UniProtKB: P214533   

Export aliases for S1PR1 gene to outside databases

Previous GC identifers: GC01P101475 GC01P099828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S1PR1 Gene:
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in
endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and
suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of
this receptor induces cell-cell adhesion. (provided by RefSeq, Jul 2008)

GeneCards Summary for S1PR1 Gene:
S1PR1 (sphingosine-1-phosphate receptor 1) is a protein-coding gene. Diseases associated with S1PR1 include lymphoblastic lymphoma, and food allergy. GO annotations related to this gene include G-protein coupled receptor activity and sphingolipid binding. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
Function: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems
to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC,
PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization
of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of
the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal
embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of
sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting
during blood vessel development. Required for normal egress of mature T cells from the thymus into the blood
stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the
regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection
against ventilator-induced lung injury

summary for S1PR1 Gene:
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently
divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of
tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest
density on leukocytes. S1P receptors couple to different G proteins to mediate a range of biological
effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal
remodeling and cell-shape changes and Gq modulates a range of cellular effector functions.

Gene Wiki entry for S1PR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the S1PR1 gene promoter:
         HFH-3   FOXO3   RelA   NF-kappaB   LCR-F1   FOXO3b   FOXL1   FOXI1   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS1PR1 promoter sequence
   Search Chromatin IP Primers for S1PR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S1PR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21

S1PR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S1PR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P101702:  view genomic region     (about GC identifiers)

Start:
101,702,305 bp from pter      End:
101,707,076 bp from pter
Size:
4,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453 (See protein sequence)
Recommended Name: Sphingosine 1-phosphate receptor 1  
Size: 382 amino acids; 42811 Da
Subunit: Interacts with GNAI1 and GNAI3
2 PDB 3D structures from and Proteopedia for S1PR1:
3V2W (3D)        3V2Y (3D)    
Secondary accessions: D3DT66 Q9BYY4 Q9NYN8

Explore the universe of human proteins at neXtProt for S1PR1: NX_P21453

Explore proteomics data for S1PR1 at MOPED

Post-translational modifications: 

  • S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular
    loop at the Thr-236 residue1
  • Glycosylation2 at Asn30, Asn36
  • Modification sites at PhosphoSitePlus

  • See S1PR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001391.2  
    ENSEMBL proteins: 
     ENSP00000305416  
    Reactome Protein details: P21453

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    Cloud-Clone Corp. ELISAs for S1PR1
    Cloud-Clone Corp. CLIAs for S1PR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    S1PR: GPCR / Class A : Lysophospholipid receptors : Sphingosine 1-phosphate

    IUPHAR Guide to PHARMACOLOGY protein family classification: S1P1 receptor
    Lysophospholipid (S1P) receptors

    4 InterPro protein domains:
     IPR000987 EDG1_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004061 S1P_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21453

    ProtoNet protein and cluster: P21453

    2 Blocks protein domains:
    IPB000987 EDG1 orphan receptor signature
    IPB004061 Sphingosine 1-phosphate receptor family signature


    UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
    Similarity: Belongs to the G-protein coupled receptor 1 family


    S1PR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S1PR1_HUMAN, P21453
    Function: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems
    to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC,
    PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization
    of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of
    the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal
    embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of
    sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting
    during blood vessel development. Required for normal egress of mature T cells from the thymus into the blood
    stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the
    regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized
    1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection
    against ventilator-induced lung injury
    Induction: By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8626678
    GO:0038036sphingosine-1-phosphate receptor activity IDA--
    GO:0046625sphingolipid binding IEA--
         
    S1PR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for S1PR1:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 8 alleles(MGI details for S1pr1):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging  muscle  nervous system 
     no phenotypic analysis  normal  vision/eye 

    S1PR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S1PR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for S1PR1
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    miRNA
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    hsa-miR-548j hsa-miR-3146 hsa-miR-106a hsa-miR-3161 hsa-miR-4325 hsa-miR-93 hsa-miR-548a-5p hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidS1PR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat S1PR1

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    GenScript: all cDNA clones in your preferred vector: S1PR1 (NM_001400)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S1PR1_HUMAN, P21453: Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to
    caveolin-enriched plasma membrane microdomains in response to oxidized
    1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031226intrinsic component of plasma membrane IDA--

    S1PR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S1PR1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3S1P3 pathway
    S1P3 pathway0.44
    Sphingosine 1-phosphate (S1P) pathway0.40
    S1P1 pathway0.41
    4Signaling events mediated by VEGFR1 and VEGFR2
    Signaling events mediated by VEGFR1 and VEGFR20.37
    5Immune response Fc epsilon RI pathway
    Fc-epsilon receptor I signaling in mast cells0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for S1PR1 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    Selected BioSystems Pathways for S1PR1 (see all 9)
        Signal Transduction of S1P Receptor
    GPCRs, Other
    S1P1 pathway
    Sphingosine 1-phosphate (S1P) pathway
    Signaling events mediated by VEGFR1 and VEGFR2


    2 Reactome Pathways for S1PR1
        Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for S1PR1):
        FoxO signaling pathway
    Neuroactive ligand-receptor interaction


    S1PR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including S1PR1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Th17 Response in human mouse rat
              Hypertension in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for S1PR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for S1PR1 (P214533 ENSP000003054164) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    PDGFRBP096193, ENSP000002617994I2D: score=3 STRING: ENSP00000261799
    AKT1P317493, ENSP000002702024I2D: score=2 STRING: ENSP00000270202
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI3P087543, ENSP000003588674I2D: score=3 STRING: ENSP00000358867
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001955blood vessel maturation ISS--
    GO:0003245cardiac muscle tissue growth involved in heart morphogenesis ISS--
    GO:0003376sphingosine-1-phosphate signaling pathway IDA--
    GO:0006935chemotaxis ISS--

    S1PR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for S1PR1
      Browse compounds at ApexBio 

    Compounds for S1PR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Sphingosine-1-phosphateEndogenous agonist at S1P1-5[26993-30-6]
    CYM 5442 hydrochlorideSelective S1P1 receptor agonist[1094042-01-9]
    JTE 013S1P2 receptor antagonist[547756-93-4]
    VPC 23019S1P1 and S1P3 antagonist[449173-19-7]
    W146Potent and selective S1P1 receptor antagonist[909725-62-8]

    2 HMDB Compounds for S1PR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--

    10 IUPHAR Ligands for S1PR1 (S1P1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    compound 26 [PMID:16190743]
    AgonistAgonist9.2216190743
    sphingosine 1-phosphate
    AgonistAgonist7.1 - 9.0511705398 11967257
    AUY954
    AgonistAgonist8.9217114004
    CYM-5442
    AgonistAgonist8.9118708635
    AFD(R)
    AgonistAgonist8.611967257
    CYM5181
    AgonistAgonist8.4118708635
    W146
    AntagonistAntagonist7.716829954
    VPC44116
    AntagonistAntagonist7.5717113298
    SEW2871
    AgonistAgonist7.5418708635
    LPA
    AgonistAgonist5.69705355

    Selected Novoseek inferred chemical compound relationships for S1PR1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphinganine 1-phosphate 89.6 4 11146117 (2), 9660876 (1)
    sphingosine 87.2 12 11726541 (2), 11230698 (2), 18474015 (1), 18644866 (1) (see all 7)
    sphingosylphosphorylcholine 86.5 5 10833459 (1), 10381367 (1), 9726638 (1)
    lysophospholipid 86.1 4 11604399 (1), 16830220 (1), 16990586 (1)
    spiegel 69.5 1 9705355 (1)
    lipid 40.9 7 10794715 (2), 17156449 (1), 18381082 (1), 16963454 (1) (see all 5)
    lysophosphatidylcholine 33.6 1 20197381 (1)
    ly294002 31.9 1 16195373 (1)
    phosphatidylinositol 23.4 2 15334188 (1), 17403093 (1)
    calcium 20.3 13 9765227 (3), 10383399 (1), 9480864 (1), 9660876 (1) (see all 7)



    S1PR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for S1PR1 gene: 
    NM_001400.4  

    Unigene Cluster for S1PR1:

    Sphingosine-1-phosphate receptor 1
    Hs.154210  [show with all ESTs]
    Unigene Representative Sequence: NM_001400
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305352(uc001dud.2 uc009weg.2) ENST00000475821 ENST00000475289

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    hsa-miR-548j hsa-miR-3146 hsa-miR-106a hsa-miR-3161 hsa-miR-4325 hsa-miR-93 hsa-miR-548a-5p hsa-miR-92b
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      QuantiTect SYBR Green Assays in human, mouse, rat S1PR1
      QuantiFast Probe-based Assays in human, mouse, rat S1PR1

    Additional mRNA sequence: 

    AF022137.1 AF233365.1 AK297005.1 AK312493.1 BC018650.1 CR541786.1 CR542269.1 

    8 DOTS entries:

    DT.112585  DT.95283317  DT.100662216  DT.100775720  DT.121387197  DT.95122743  DT.95137763  DT.95137764 

    Selected AceView cDNA sequences (see all 105):

    T27666 BC018650 AW515813 CR541786 AI636061 AW827198 BG251038 BM021365 
    BX104139 AA304390 BU677564 F05373 CK820076 BE710296 AI566829 BP345893 
    BU681185 AF233365 BQ723639 BQ003555 F01623 AA370448 BM021114 BM354114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S1PR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTATTTT
    S1PR1 Expression
    About this image


    S1PR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angioblasts Embryonic Blood Islands
             Human umbilical vein endothelial cells (HUVEC)
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Primitive Streak (Early Embryo)
             Extraembryonic Mural Cells Extraembryonic Mesoderm
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
    S1PR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S1PR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154210

    UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
    Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts,
    melanocytes, and cells of epithelioid origin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S1PR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S1pr11 , 5 sphingosine-1-phosphate receptor 11, 5 88.13(n)1
    94.24(a)1
      3 (50.00 cM)5
    136091  NM_007901.51  NP_031927.21 
     1157104335 
    chicken
    (Gallus gallus)
    Aves S1PR11 sphingosine-1-phosphate receptor 1 75.29(n)
    86.13(a)
      424462  XM_004936550.1  XP_004936607.1 
    lizard
    (Anolis carolinensis)
    Reptilia S1PR16
    sphingosine-1-phosphate receptor 1
    58(a)
    1 ↔ 1
    4(87277932-87405993)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55742 Xenopus laevis transcribed sequence with moderate similarity more 76.5(n)    CD361371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii edg12 endothelial differentiation, sphingolipid G-protein-coupled more 78.09(n)   64617  AF321294.1 


    ENSEMBL Gene Tree for S1PR1 (if available)
    TreeFam Gene Tree for S1PR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S1PR1 gene
    CNR12  GPR122  LPAR22  CNR22  S1PR32  S1PR22  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    9 SIMAP similar genes for S1PR1 using alignment to 1 protein entry:     S1PR1_HUMAN:
    EDG1    S1PR3    S1PR2    LPAR1    EDG2    LPAR3
    S1PR4    S1PR5    LPAR2

    S1PR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S1PR1 (see all 304)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562364171,2
    --99829696(+) GGGGCG/TCGGGG 1 -- int10--------
    rs353272871,2
    C--101701146(+) TTTTT-/TGGCAA 1 -- us2k10--------
    rs350163881,2
    C--101704233(+) AAAAA-/ATCTCT 1 -- int10--------
    rs120852131,2
    --101704234(+) TTTTTA/TAAAAA 1 -- int10--------
    rs2022388551,2
    C--101707562(+) CATGTG/TTNNNN 1 -- ds50010--------
    rs349572511,2
    C--101707568(+) TTTTT-/G/TG  
            
    TTTTT
    1 -- ds50011NA 2
    rs1140735521,2
    F--101723630(+) TGTTAC/TATGAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs761168081,2
    C,F--101723723(+) TGAGTG/AGTTTT 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs603712311,2
    C,F--101723775(+) ACTTGT/AACAGT 1 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs749543351,2
    --101723811(+) TAAATA/CTAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for S1PR1 (101702305 - 101707076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for S1PR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871867CNV Loss21882294

    Human Gene Mutation Database (HGMD): S1PR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S1PR1
    DNA2.0 Custom Variant and Variant Library Synthesis for S1PR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601974    OMIM disorders: --

    Selected diseases for S1PR1 (see all 37):    
    About MalaCards
    lymphoblastic lymphoma    food allergy    endotheliitis    follicular thyroid carcinoma
    abdominal aortic aneurysm    lymphopenia    neuritis    vascular disease
    gout    estrogen-receptor positive breast cancer    aortic aneurysm    diffuse large b-cell lymphoma
    sepsis    vasculitis    sjogren's syndrome    b-cell lymphomas
    gingivitis    sinusitis    thyroid cancer    pertussis

    2 diseases from the University of Copenhagen DISEASES database for S1PR1:
    Multiple sclerosis     Lymphopenia

    S1PR1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for S1PR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 38.4 9 19810093 (6), 19937366 (1), 12175535 (1)
    glioma 33.1 7 19810093 (3), 11146117 (3), 19937366 (1)
    autoimmunity 24.9 1 15578083 (1)
    inflammation 20.8 2 18474015 (1)
    neovascularization 11.6 1 15334188 (1)
    sepsis 0 3 15710622 (1), 19278594 (1)
    breast cancer 0 1 10493533 (1)
    ovarian cancer 0 3 17349972 (1), 10818454 (1)
    vascular diseases 0 2 11557736 (1)
    tumors 0 3 19810093 (2), 17203465 (1)

    Genetic Association Database (GAD): S1PR1
    Human Genome Epidemiology (HuGE) Navigator: S1PR1 (8 documents)

    Export disorders for S1PR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S1PR1 gene, integrated from 10 sources (see all 241):
    (articles sorted by number of sources associating them with S1PR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. (PubMed id 2160972)1, 2, 3, 9 Hla T. and Maciag T. (J. Biol. Chem. 1990)
    2. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (PubMed id 9488656)1, 2, 3 Lee M.-J.... Hla T. (Science 1998)
    3. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. (PubMed id 11230698)1, 2, 9 Hobson J.P.... Spiegel S. (Science 2001)
    4. The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. (PubMed id 8626678)1, 2, 9 Lee M.-J.... Hla T. (J. Biol. Chem. 1996)
    5. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)1, 2, 9 Ancellin N. and Hla T. (J. Biol. Chem. 1999)
    6. Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. (PubMed id 19286607)1, 2, 9 Singleton P.A....Birukov K.G. (Circ. Res. 2009)
    7. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (PubMed id 11583630)1, 2, 9 Lee M.-J.... Hla T. (Mol. Cell 2001)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility. (PubMed id 20624651)1, 4 Sun X....Garcia J.G. (J. Allergy Clin. Immunol. 2010)
    10. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1901 HGNC: 3165 AceView: EDG1 Ensembl:ENSG00000170989 euGenes: HUgn1901
    ECgene: S1PR1 Kegg: 1901 H-InvDB: S1PR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for S1PR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for S1PR1 gene:
    Search GeneIP for patents involving S1PR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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