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S100Z Gene

protein-coding GIFtS: 47

GC05P076181

S100 calcium binding protein Z
(Previous names: S100 calcium binding protein, zeta )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Gm625 ^¹, ²
S100-zeta ^¹, ²

Descriptions
S100 calcium binding protein Z ^²
S100 calcium binding protein, zeta ^¹, ²
S100 calcium-binding protein Z ^³

External Ids
HGNC: 30367¹
Entrez Gene: 170591²
UniProtKB: Q8WXG8³
Ensembl: ENSG00000171643⁷

Search outside databases for aliases for S100Z gene

Previous GC identifers: GC05P074951 GC05P076380 GC05P076184 GC05P076229

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100Z:

Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type

specific expression patterns. For additional background information on S100 proteins, see MIM

114085.[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the S100Z gene

Entrez Gene cytogenetic band: 5q13.3 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13.3

S100Z Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P076181: (about GC identifiers)

Start:	76,181,582 bp from pter
End:	76,252,812 bp from pter
Size:	71,231 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S100Z_HUMAN, Q8WXG8 (See protein sequence)

Recommended Name: Protein S100-Z

Size: 99 amino acids; 11562 Da

Subunit: Homodimer. Interacts with S100P

Miscellaneous: This protein binds two calcium ions

REFSEQ proteins: NP_570128.2

ENSEMBL proteins:

ENSP00000320430

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S100Z)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: S100Z

Antibodies for S100Z:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (S100Z), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for S100Z

Assays for S100Z:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WXG8

ProtoNet protein and cluster: Q8WXG8

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S100Z_HUMAN, Q8WXG8

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100Z)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100Z)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_130772

Applied Biosystems Silencer® siRNAs for S100Z

Sigma-Aldrich siRNA for S100Z

Sigma-Aldrich shRNA for S100Z

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100Z
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_130772
Myc/DDK tagged cDNA clone in CMV expression vector: NM_130772
untagged cDNA clones in CMV expression vector (see all 2): NM_130772

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_130772

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for S100Z (ENSP00000320430³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
S100A14	ENSP00000357689³	STRING (score=.719)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100Z

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100Z)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100Z)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_130772

Sigma-Aldrich siRNA for S100Z

Sigma-Aldrich shRNA for S100Z

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_130772

REFSEQ mRNAs for S100Z gene:

NM_130772.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_130772

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_130772
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_130772
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_130772

Additional cDNA sequence:

AF437876.1 BC022320.1

2 DOTS entries:

DT.91693746 DT.95286045

14 AceView cDNA sequences:

BI766857 CD368348 BX281742 CA429693 BC022320 BG529999 BG541527 BU727516

NM_130772 AF437876 CD639003 BM687054 AV763723 AJ713880

highest scoring ESTs for S100Z:

AF437876 BC022320 BG541527 BI766857 AV763723 BG529999 BX281742 CA429693 CD368348 CD639003

Unigene Cluster for S100Z:

S100 calcium binding protein Z

Hs.482563 [show with all ESTs]

Unigene Representative Sequence: NM_130772

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000317593

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100Z expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100Z

¹ / ²

1 probe-set matching S100Z gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1554876_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTAGAATCT

SOURCE GeneReport for Unigene cluster: Hs.482563
UniProtKB/Swiss-Prot: S100Z_HUMAN, Q8WXG8
Tissue specificity: Highest level of expression in spleen and leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100Z gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	S100Z¹	--	S100 calcium binding protein Z	100(n) 100(a)	471509 XM_526887.2 XP_526887.2
cow (Bos taurus)	S100Z¹	--	S100 calcium binding protein Z	88.55(n) 85.86(a)	528723 XM_607154.2 XP_607154.2
rat (Rattus norvegicus)	S100z¹	--	S100 calcium binding protein Z	86.2(n) 89.9(a)	294661 XM_226710.3 XP_226710.1
mouse (Mus musculus)	S100z^{1, 5}	13⁵	S100 calcium binding protein, zeta^{1, 5}	87.21(n)¹ 89.9(a)¹	268686¹ NM_001081159.1¹ NP_001074628.1¹ BC147382⁵ BC147383⁵
chicken (Gallus gallus)	S100Z¹	--	S100 calcium binding protein Z	72.57(n) 68.75(a)	431598 XM_429152.2 XP_429152.2

About this table Species with no ortholog for S100Z

ENSEMBL Gene Tree for S100Z

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S100Z gene

S100A6² S100A3² S100A1² S100A5² S100A2² S100A4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/417 NCBI SNPs in S100Z are shown (see all 417 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 51)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1320308^1,2	A,C,F,H,O	76207008(-)	`TCCTTG/TCCTTG`	1	E/A	mis¹ ese³ trp³		12		EU EA WA NA	1054
--	rs2657047^1,2	A,C,F,H,O	76253260(+)	`CATCTA/GTCTCT`	1	--	ng3¹		4		EU EA WA	420
--	rs6876227^1,2	A,C,F,H	76252715(+)	`CATGTA/GTCTAT`	1	--	ut3¹		5		EU WA NA	378
--	rs2460507^1,2	A,C,F,H	76180530(+)	`ttaagT/Acaagc`	1	--	ng5¹		4		EU EA WA	420
	rs4704369^1,2	A,C,F,H	76180621(+)	`cgataC/Tacgat`	1	--	ng5¹		2		EU WA	218
	rs6453259^1,2	A,C,F,H	76201774(+)	`tctgtA/Gtagac`	1	--	ut5¹		8		EU EA WA NA	624
--	rs4254887^1,2	A,C	76253291(+)	`AGGCCG/TGGTGC`	1	--	ng3¹		0	--	--	--	--
--	rs1715764^1,2	A,C	76252847(-)	`ATATTG/TTGATA`	1	--	ng3¹		0	--	--	--	--
--	rs6885207^1,2	C	76180991(+)	`GAAATA/GCTGTG`	1	--	ng5¹		0	--	--	--	--
--	rs4704370^1,2	C	76180709(+)	`ctcacC/Gcctat`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for S100Z (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610103

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for S100Z gene:

Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. (PubMed id 11747429)^{1, 2, 3, 4} Gribenko A.V.... Makhatadze G.I. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 170591	HGNC: 30367	AceView: S100Z	Ensembl:ENSG00000171643	euGenes: HUgn170591
ECgene: S100Z	H-InvDB: S100Z

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for S100Z
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S100Z:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100Z-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100Z		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S100Z		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for S100Z

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for S100Z

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S100Z Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for S100Z

Summaries
for S100Z

Genomic Location
for S100Z

Proteins
for S100Z

Protein Domains/
Families
for S100Z

Gene Function
for S100Z

Pathways & Interactions
for S100Z

Drugs & Compounds
for S100Z

Transcripts
for S100Z

Expression
for S100Z

Orthologs
for S100Z

Paralogs
for S100Z

SNPs/Variants
for S100Z

Disorders & Mutations
for S100Z

Medical News
for S100Z

Publications
for S100Z

Search for S100Z

Genome Databases showing S100Z

Other Databases showing S100Z

Specialized Databases showing S100Z

Licensable Technologies
for S100Z

Services
for S100Z

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100Z Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor S100Z

Summariesfor S100Z

Genomic Locationfor S100Z

Proteinsfor S100Z

Protein Domains/Familiesfor S100Z

Gene Functionfor S100Z

Pathways & Interactionsfor S100Z

Drugs & Compoundsfor S100Z

Transcriptsfor S100Z

Expression for S100Z

Orthologsfor S100Z

Paralogsfor S100Z

SNPs/Variantsfor S100Z

Disorders & Mutationsfor S100Z

Medical Newsfor S100Z

Publicationsfor S100Z

Search for S100Z

Genome Databases showing S100Z

Other Databases showing S100Z

Specialized Databases showing S100Z

Licensable Technologiesfor S100Z

Servicesfor S100Z

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100Z

Summaries
for S100Z

Genomic Location
for S100Z

Proteins
for S100Z

Protein Domains/
Families
for S100Z

Gene Function
for S100Z

Pathways & Interactions
for S100Z

Drugs & Compounds
for S100Z

Transcripts
for S100Z

Expression
for S100Z

Orthologs
for S100Z

Paralogs
for S100Z

SNPs/Variants
for S100Z

Disorders & Mutations
for S100Z

Medical News
for S100Z

Publications
for S100Z

Licensable Technologies
for S100Z

Services
for S100Z