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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100Z Gene

protein-coding   GIFtS: 50
GCID: GC05P076181

S100 calcium binding protein Z

(Previous names: S100 calcium binding protein, zeta )
 Explore 1 disease affiliated with
S100Z via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for S100Z    

Aliases
for S100Z gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
S100 Calcium Binding Protein Z1 2
Gm6251 2
S100-Zeta1
S100 Calcium Binding Protein, Zeta1 2
S100 Calcium-Binding Protein Z2 3
Protein S100-Z2

External Ids:    HGNC: 303671   Entrez Gene: 1705912   Ensembl: ENSG000001716437   OMIM: 6101035   UniProtKB: Q8WXG83   

Export aliases for S100Z gene to outside databases

Previous GC identifers: GC05P074951 GC05P076380 GC05P076184 GC05P076229 GC05P071353


Summaries
for S100Z gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for S100Z:
Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression
patterns. For additional background information on S100 proteins, see MIM 114085.(supplied by OMIM, Mar 2008)




Genomic Views
for S100Z gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100Z gene promoter:
         ER-alpha   STAT5B   p53   AML1a   GATA-1   Nkx6-1   FOXC1   deltaCREB   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100Z promoter sequence
   Search SABiosciences Chromatin IP Primers for S100Z

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100Z


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13.3

S100Z Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100Z gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P076181:  view genomic region     (about GC identifiers)

Start:
 76,145,826 bp from pter      End:
 76,217,475 bp from pter
Size:
 71,650 bases      Orientation:
 plus strand

Proteins
for S100Z gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S100Z_HUMAN, Q8WXG8 (See protein sequence)
Recommended Name: Protein S100-Z  
Size: 99 amino acids; 11620 Da
Subunit: Homodimer. Interacts with S100P
Miscellaneous: This protein binds two calcium ions

Explore the universe of human proteins at neXtProt for S100Z: NX_Q8WXG8

S100Z Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_570128.2  
ENSEMBL proteins: 
 ENSP00000426768   ENSP00000320430  

Human Recombinant Protein Products: 
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Uscn ELISAs and CLIAs for S100Z

Protein Domains /
Families
for S100Z gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
S100Z for domains           About GeneDecksing

5 InterPro domains/families:
 IPR018247 EF_Hand_1_Ca_BS
 IPR011992 EF-hand-like_dom
 IPR002048 EF_hand_Ca-bd
 IPR013787 S100_Ca-bd_sub
 IPR001751 S100/CaBP-9k_CS

Graphical View of Domain Structure for InterPro Entry Q8WXG8

ProtoNet protein and cluster: Q8WXG8

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S100Z_HUMAN, Q8WXG8
Similarity: Belongs to the S-100 family
Similarity: Contains 2 EF-hand domains


Function
for S100Z gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
Products:    		Browse 3'-UTR reporter clones for miRNA target validation
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat S100Z
1 QIAGEN miScript miRNA Assays for microRNA that regulate S100Z:
hsa-miR-4324
SwitchGear 3'UTR luciferase reporter plasmid: S100Z 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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In Situ Assay
Products:   
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005509calcium ion binding IEA--


S100Z for ontologies           About GeneDecksing



Pathways & Interactions
for S100Z gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S100Z

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for S100Z (Q8WXG83 ENSP000003204304) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
S100PP258153, ENSP000002963704I2D: score=2 STRING: ENSP00000296370
About this table

Drugs & Compounds
for S100Z gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for S100Z

1 HMDB Compound for S100Z    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Search CenterWatch for drugs/clinical trials and news about S100Z 

Transcripts
for S100Z gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for S100Z gene: 
NM_130772.3  

Unigene Cluster for S100Z:

S100 calcium binding protein Z
Hs.482563  [show with all ESTs]
Unigene Representative Sequence: NM_130772
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000513010(uc003kep.1) ENST00000317593(uc003keq.4)

miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate S100Z:
hsa-miR-4324
SwitchGear 3'UTR luciferase reporter plasmid: S100Z 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S100Z (see all 4)
OriGene shRNA RFP: S100Z
OriGene siRNA: S100Z
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat S100Z
Clone
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GenScript: all cDNA clones in your preferred vector: S100Z (NM_130772)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100Z 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100Z
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100Z

Additional cDNA sequence: 

AF437876.1 BC022320.1 

2 DOTS entries:

DT.91693746  DT.95286045 

14 AceView cDNA sequences:

CD368348 BI766857 BX281742 NM_130772 BG541527 BC022320 BG529999 CA429693 
BU727516 AF437876 BM687054 CD639003 AV763723 AJ713880 

GeneLoc Exon Structure


Expression
for S100Z gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

S100Z expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTAGAATCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

S100Z expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Posterior foregut-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See S100Z Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100Z

SOURCE GeneReport for Unigene cluster: Hs.482563

UniProtKB/Swiss-Prot: S100Z_HUMAN, Q8WXG8
Tissue specificity: Highest level of expression in spleen and leukocytes

    SABiosciences Custom PCR Arrays for S100Z
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100Z
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100Z

Orthologs
for S100Z gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for S100Z gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia S100z1 , 5 S100 calcium binding protein, zeta1, 5 87.21(n)1
89.9(a)1		   13 (49.53 cM)5
2686861  NM_001081159.11  NP_001074628.11 
 954773015 
chicken
(Gallus gallus)		 Aves S100Z1 S100 calcium binding protein Z 72.57(n)
68.75(a)		   431598  XM_429152.2  XP_429152.2 
lizard
(Anolis carolinensis)		 Reptilia S100Z6
 --
 74(a)
 1 ↔ 1
 2(14135151-14144288)
zebrafish
(Danio rerio)		 Actinopterygii s100z1 S100 calcium binding protein Z 68.69(n)
67.68(a)		   554089  NM_001024391.2  NP_001019562.1 


ENSEMBL Gene Tree for S100Z (if available)
TreeFam Gene Tree for S100Z (if available) 

Paralogs
for S100Z gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for S100Z gene
S100A112  S100A62  S100A12  S100A122  S100A82  S100B2  S100A42  S100A32  
S100A102  S100A22  S100P2  S100A52  S100A92  
18/25 SIMAP similar genes for S100Z using alignment to 1 protein entry:     S100Z_HUMAN(see all similar genes):
S100B    S100A1    S100A16    S100A9    S100P    S100A4
S100A5    S100A10    S100A11    S100A12    HRNR    S100A6
FLG    S100A13    CABP2    CRNN    FLG2    S100G

S100Z for paralogs           About GeneDecksing



Genomic Variants
for S100Z gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1451 NCBI SNPs in S100Z are shown (see all 1451)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 5 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs125156021,2
C,F,H,--76143838(+) TCAAAC/TTCCTG 1 -- us2k11Minor allele frequency- T:0.10EA 120
rs1180255421,2
F,--76143966(+) CCAGGC/TTGTGT 1 -- us2k11Minor allele frequency- T:0.03EA 120
rs1156345301,2
C,--76143978(+) GAACTC/TTTGGG 1 -- us2k10--------
rs1999984341,2
--76144010(+) TGCCT-/CCCAAA 1 -- us2k10--------
rs1441542511,2
--76144102(+) TCTTGA/CCCAGG 1 -- us2k10--------
rs1922106861,2
--76144196(+) AGCTGG/TGATTA 1 -- us2k10--------
rs1848389281,2
--76144206(+) ACAGGC/TGCACA 1 -- us2k10--------
rs1159018471,2
C,F,--76144271(+) AGAACA/GTATCT 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs1487017111,2
--76144297(+) GGCTGA/GTGCCT 1 -- us2k10--------
rs1115414731,2
C,--76144328(+) AGCCAG/AGCTGG 1 -- us2k13Minor allele frequency- A:0.15WA EA 240

HapMap Linkage Disequilibrium report for S100Z (76145826 - 76217475 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for S100Z
     1 CNV: 47921

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Disorders / Diseases
for S100Z gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
S100Z for disorders           About GeneDecksing

OMIM gene information: 610103    OMIM disorders: --

1 disease for S100Z:    About MalaCards
ulcerative colitis

Human Genome Epidemiology (HuGE) Navigator: S100Z (1 document)

Export disorders for S100Z gene to outside databases

Publications
for S100Z gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for S100Z gene integrated from 9 sources:
(articles sorted by number of sources associating them with S100Z)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. (PubMed id 11747429)1, 2, 3, 9 Gribenko A.V.... Makhatadze G.I. (2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Genetic analysis in a Dutch study sample identifies m ore ulcerative colitis susceptibility loci and shows their additive role in dis ease risk. (PubMed id 19861958)1 Festen E.A....Weersma R.K. (2010)
  4. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for S100Z gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing S100Z gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 170591 HGNC: 30367 AceView: S100Z Ensembl:ENSG00000171643 euGenes: HUgn170591
ECgene: S100Z H-InvDB: S100Z

Other Databases showing S100Z gene

(According to HUGE)
About This Section
   --

Specialized Databases showing S100Z gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for S100Z Pharmacogenomics, SNPs, Pathways

Intellectual Property
for S100Z gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for S100Z gene:
Search GeneIP for patents involving S100Z

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for S100Z gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section

 
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VWF
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von Willebrand factor
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