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Aliases for S100Z Gene

Aliases for S100Z Gene

  • S100 Calcium Binding Protein Z 2 3 5
  • S100 Calcium Binding Protein, Zeta 2 3
  • S100 Calcium-Binding Protein Z 3 4
  • S100-Zeta 3
  • Gm625 3

External Ids for S100Z Gene

Previous GeneCards Identifiers for S100Z Gene

  • GC05P074951
  • GC05P076380
  • GC05P076184
  • GC05P076229
  • GC05P076181
  • GC05P071353

Summaries for S100Z Gene

Entrez Gene Summary for S100Z Gene

  • Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]

GeneCards Summary for S100Z Gene

S100Z (S100 Calcium Binding Protein Z) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100Z Gene

Genomics for S100Z Gene

Regulatory Elements for S100Z Gene

Enhancers for S100Z Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around S100Z on UCSC Golden Path with GeneCards custom track

Promoters for S100Z Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S100Z on UCSC Golden Path with GeneCards custom track

Genomic Location for S100Z Gene

76,850,001 bp from pter
76,952,882 bp from pter
102,882 bases
Plus strand

Genomic View for S100Z Gene

Genes around S100Z on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100Z Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100Z Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100Z Gene

Proteins for S100Z Gene

  • Protein details for S100Z Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-Z
    Protein Accession:

    Protein attributes for S100Z Gene

    99 amino acids
    Molecular mass:
    11620 Da
    Quaternary structure:
    • Homodimer. Interacts with S100P.
    • This protein binds two calcium ions.

neXtProt entry for S100Z Gene

Proteomics data for S100Z Gene at MOPED

Post-translational modifications for S100Z Gene

No Post-translational modifications

Other Protein References for S100Z Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100Z Gene

Domains & Families for S100Z Gene

Suggested Antigen Peptide Sequences for S100Z Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100Z: view

Function for S100Z Gene

Phenotypes for S100Z Gene

genes like me logo Genes that share phenotypes with S100Z: view

Animal Model Products

miRNA for S100Z Gene

miRTarBase miRNAs that target S100Z

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100Z Gene

Localization for S100Z Gene

Subcellular locations from

Jensen Localization Image for S100Z Gene COMPARTMENTS Subcellular localization image for S100Z gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for S100Z Gene

Pathways & Interactions for S100Z Gene

SuperPathways for S100Z Gene

No Data Available

Interacting Proteins for S100Z Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000320430 Q8WXG8-S100Z_HUMAN for S100Z Gene via STRING I2D

Gene Ontology (GO) - Biological Process for S100Z Gene


No data available for Pathways by source and SIGNOR curated interactions for S100Z Gene

Drugs & Compounds for S100Z Gene

(1) Drugs for S100Z Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with S100Z: view

Transcripts for S100Z Gene

mRNA/cDNA for S100Z Gene

(8) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100Z Gene

S100 calcium binding protein Z:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100Z Gene

No ASD Table

Relevant External Links for S100Z Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100Z Gene

mRNA expression in normal human tissues for S100Z Gene

mRNA differential expression in normal tissues according to GTEx for S100Z Gene

This gene is overexpressed in Whole Blood (x19.4) and Spleen (x7.5).

SOURCE GeneReport for Unigene cluster for S100Z Gene Hs.482563

mRNA Expression by UniProt/SwissProt for S100Z Gene

Tissue specificity: Highest level of expression in spleen and leukocytes.
genes like me logo Genes that share expression patterns with S100Z: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for S100Z Gene

Orthologs for S100Z Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100Z Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia S100Z 35
  • 88.55 (n)
  • 85.86 (a)
S100Z 36
  • 86 (a)
(Canis familiaris)
Mammalia S100Z 35
  • 86.23 (n)
  • 74.73 (a)
-- 36
  • 45 (a)
(Mus musculus)
Mammalia S100z 35
  • 87.21 (n)
  • 89.9 (a)
S100z 16
S100z 36
  • 90 (a)
(Pan troglodytes)
Mammalia S100Z 35
  • 99.66 (n)
  • 98.99 (a)
S100Z 36
  • 100 (a)
(Rattus norvegicus)
Mammalia S100z 35
  • 86.2 (n)
  • 89.9 (a)
(Monodelphis domestica)
Mammalia S100Z 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia S100Z 36
  • 71 (a)
(Gallus gallus)
Aves S100Z 35
  • 72.57 (n)
  • 68.75 (a)
S100Z 36
  • 69 (a)
(Anolis carolinensis)
Reptilia S100Z 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia s100z 35
  • 76.77 (n)
  • 75.76 (a)
(Danio rerio)
Actinopterygii s100z 35
  • 68.69 (n)
  • 67.68 (a)
s100z 36
  • 68 (a)
Species with no ortholog for S100Z:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100Z Gene

Gene Tree for S100Z (if available)
Gene Tree for S100Z (if available)

Paralogs for S100Z Gene

genes like me logo Genes that share paralogs with S100Z: view

Variants for S100Z Gene

Sequence variations from dbSNP and Humsavar for S100Z Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1320308 - 76,875,427(-) TCCTT(C/G/T)CCTTG reference, missense
rs813509 -- 76,940,439(-) caagg(C/T)tccat intron-variant
rs874228 -- 76,929,100(+) GAGAA(A/G)CCTAA intron-variant
rs905854 -- 76,928,300(+) AGATG(C/T)CTGAA intron-variant
rs905855 -- 76,929,052(+) TGGCT(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100Z Gene

Variant ID Type Subtype PubMed ID
esv34133 CNV Loss 18971310
nsv524024 CNV Loss 19592680
nsv830355 CNV Gain 17160897

Variation tolerance for S100Z Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for S100Z Gene

Disorders for S100Z Gene

Relevant External Links for S100Z

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for S100Z Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100Z Gene

Publications for S100Z Gene

  1. Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. (PMID: 11747429) Gribenko A.V. … Makhatadze G.I. (Biochemistry 2001) 2 3 4 23 67
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for S100Z Gene

Sources for S100Z Gene