S100PBP Gene
protein-coding GIFtS: 45
GCID: GC01P033283
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S100P binding protein
| |
Aliases
for S100PBP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| S100P Binding Protein1 2 | | S100PBPR1 2 3 5 | | FLJ129031 | | S100P Binding Protein 12 | | S100P-Binding Protein2 | | S100P-Binding Protein Riken3 |
Export aliases for S100PBP gene to outside databasesPrevious GC identifers: GC01P032954 GC01P033055 GC01P031399 |
Summaries
for S100PBP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for S100PBP:
This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P.Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternativelyspliced transcript variants have been described. (provided by RefSeq, Jan 2012)
|
Genomic Views
for S100PBP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the S100PBP gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 NF-kappaB E2F E2F-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for S100PBP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100PBP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1S100PBP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P033283: view genomic region
(about GC identifiers)
Start:
|
33,282,368 bp from pter |
End:
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33,324,476 bp from pter |
Size:
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42,109 bases |
Orientation:
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plus strand |
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Proteins
for S100PBP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S1PBP_HUMAN, Q96BU1 (See
protein sequence)Recommended Name: S100P-binding protein Size: 408 amino acids; 45582 Da
Subunit: Interacts with S100P
Subcellular location: Nucleus. Note=Colocalizes with S100P in the nucleus
Sequence caution: Sequence=BAB14335.1; Type=Erroneous initiation;
Secondary accessions: B3KR04 D3DPQ5 Q5HYH3 Q9H997Alternative splicing: 2 isoforms: Q96BU1-1 Q96BU1-2 Explore the universe of human proteins at neXtProt for S100PBP: NX_Q96BU1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BU1
S100PBP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243050.1 NP_073590.2
ENSEMBL proteins: ENSP00000434933 ENSP00000362575 ENSP00000362574 ENSP00000431921 ENSP00000431940 ENSP00000435856 ENSP00000431432 ENSP00000433456 ENSP00000381296
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
S100PBP for ontologies About GeneDecksing
S100PBP Antibody Products:
Assay Products for S100PBP: |
Protein
Domains /
Families
for S100PBP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
S100PBP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96BU1ProtoNet protein and cluster: Q96BU1 |
Function
for S100PBP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100PBP (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100PBP (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): S100PBP (NM_022753) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100PBP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100PBP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100PBP |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0048306 | calcium-dependent protein binding |
IPI | 15632002 |
S100PBP for ontologies About GeneDecksing
|
Pathways & Interactions
for S100PBP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S100PBP
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for S100PBP (ENSP000003625744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for S100PBP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for S100PBP
Search CenterWatch for drugs/clinical trials and news about S100PBP / S1PBP
|
Transcripts
for S100PBP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for S100PBP gene (3 alternative transcripts): NM_001256121.1 NM_022753.3 NM_001017406.1 Unigene Cluster for S100PBP: S100P binding protein Hs.440880 [show with all ESTs]Unigene Representative Sequence: NM_02275317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530710 ENST00000373476 ENST00000373475(uc001bvz.3 uc001bwc.3 uc001bwd.3)
ENST00000529027 ENST00000531123 ENST00000356689 ENST00000526230 ENST00000531256
ENST00000477248 ENST00000482212 ENST00000474103 ENST00000530552 ENST00000525203
ENST00000524535 ENST00000527692 ENST00000475486 ENST00000398243(uc001bwa.1 uc001bwb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100PBP (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100PBP (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): S100PBP (NM_022753) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100PBP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100PBP |
Additional cDNA sequence: AK022965.1 AK023920.1 AK025811.1 AK090711.1 BC015175.1 BX647667.1 BX647916.1 15 DOTS entries: DT.110442 DT.100741950 DT.443029 DT.121452402 DT.92427789 DT.100681792 DT.101973133 DT.100764972 DT.121452386 DT.97788343 DT.100699868 DT.91730718 DT.92002223 DT.95125151 DT.97812376 24/154 AceView cDNA sequences (see all 154): AI287900 AA557330 AA495881 CA429172 AV652749 BX284058 AA112172 BM716712 BQ427456 AA258844 AI222041 BM712853 AA256293 CR611064 AI051620 BF939421 AI285328 AI024413 BX647916 BQ721675 CA308906 AA302355 BC015175 BX641803
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for S100PBP (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c |
|---|
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| SP1: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for S100PBP
|
Expression
for S100PBP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| S100PBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTCCCT
About this image
See S100PBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100PBP
SOURCE GeneReport for Unigene cluster: Hs.440880
UniProtKB/Swiss-Prot: S1PBP_HUMAN, Q96BU1Tissue specificity: Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressedpredominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulatedin various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductaladenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level)
SABiosciences Custom PCR Arrays for S100PBP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100PBP
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100PBP |
Orthologs
for S100PBP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for S100PBP gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for S100PBP (if available)
TreeFam Gene Tree for S100PBP (if available) |
Paralogs
for S100PBP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for S100PBP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for S100PBP (33282368 - 33324476 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for S100PBP
1 CNV: 48310 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100PBP |
|
Disorders
/ Diseases
for S100PBP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
S100PBP for disorders About GeneDecksing
OMIM gene information: 611889
OMIM disorders: --
4  diseases for S100PBP: About MalaCardspancreatic ductal adenocarcinoma adenocarcinoma pancreatitis pancreatic cancer
Export disorders for S100PBP gene to outside databases
|
Publications
for S100PBP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for S100PBP gene integrated from 9 sources:
(articles sorted by number of sources associating them with S100PBP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. (PubMed id 15632002)1, 2, 9 Dowen S.E....Lemoine N.R. (2005)
- Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. (PubMed id 18089492)1, 2 Deng H.... Lin F. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- S100P-binding protein, S100PBP, mediates adhesion thro ugh regulation of cathepsin Z in pancreatic cancer cells. (PubMed id 22330678)1 Lines K.E....Crnogorac-Jurcevic T. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for S100PBP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing S100PBP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing S100PBP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing S100PBP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for S100PBP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for S100PBP gene:
Search GeneIP for patents involving S100PBP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for S100PBP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for S100PBP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S100PBP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100PBP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for S100PBP | | OriGene 3'-UTR Clone for S100PBP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100PBP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100PBP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat S100PBP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100PBP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100PBP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat S100PBP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100PBP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100PBP |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100PBP |
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