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S100PBP Gene

protein-coding   GIFtS: 49

GC01P033055
S100P binding protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp313K2325 2
FLJ12903 1, 2
OTTHUMP00000004045 2
OTTHUMP00000004046 2
S100PBPR 1, 2, 3, 5
Descriptions
S100P binding protein 2
S100P binding protein 1 2
S100P binding protein Riken 3
External Ids
HGNC: 257681
Entrez Gene: 647662
UniProtKB: Q96BU13
Ensembl: ENSG000001164977
Search outside databases for aliases for S100PBP gene

Previous GC identifer: GC01P032954

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100PBP gene  

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

S100PBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P033055:     (about GC identifiers)

Start:
33,055,630 bp from pter
End:
33,097,063 bp from pter
Size:
41,434 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S1PBP_HUMAN, Q96BU1 (See protein sequence)
Recommended Name: S100P-binding protein  
Size: 408 amino acids; 45582 Da
Subunit: Interacts with S100P
Subcellular location: Nucleus. Note=Colocalizes with S100P in the nucleus
Secondary accessions: B3KR04 Q5HYH3 Q9H997
Alternative splicing: 2 isoforms:  Q96BU1-1   Q96BU1-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001017406.1  NP_073590.2  


ENSEMBL proteins: 
ENSP00000349117 ENSP00000381296 ENSP00000362575 ENSP00000362574 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (S100P binding protein)
Human Recombinant Proteins from Abnova (S100PBP)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA15632002
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Antibodies for S100PBP: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (S100P binding protein), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (S100PBP)
Novus Biologicals Antibody for S100PBP

Assays for S100PBP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96BU1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (S100PBP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022753

              Applied Biosystems Silencer® siRNAs for S100PBP

              Sigma-Aldrich siRNA for S100PBP  
                     Sigma-Aldrich shRNA for S100PBP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for S100PBP
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001017406
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001017406
                                 untagged cDNA clones in CMV expression vector (see all 4): BC015175 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_022753

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0048306 calcium-dependent protein binding IPI15632002
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for S100PBP (ENSP000003625753) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
--ENSP000003720193STRING (score=.935)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100PBP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (S100PBP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022753

              Sigma-Aldrich siRNA for S100PBP  
                     Sigma-Aldrich shRNA for S100PBP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001017406  NM_022753  

REFSEQ mRNAs for S100PBP gene (2 alternative transcripts): 

NM_001017406.1   NM_022753.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001017406  NM_022753  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001017406
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001017406
                                 untagged cDNA clones in CMV expression vector (see all 4): BC015175 

Additional cDNA sequence: 

AK022965.1 AK023920.1 AK025811.1 AK090711.1 BC015175.1 BX647667.1 BX647916.1 CR611064.1 
CR626594.1 

18 DOTS entries:

DT.110442  DT.100741950  DT.121452402  DT.443029  DT.100764972  DT.92427789  DT.40298961  DT.100681792 
DT.101973133  DT.121452341  DT.121452386  DT.97788343  DT.100699868  DT.40293572  DT.95125151  DT.91730718 
DT.92002223  DT.97812376 

24/154 AceView cDNA sequences (see all 154 ):

AV652749 CA429172 BQ721675 BX647916 AI285328 AI216340 CR626594 BM712853 
CR611064 BC015175 BF939421 AA256202 AI287900 AA557330 BX641803 AA361244 
AA302355 AA424280 AA258844 AA256454 CA308906 BX284058 BM716712 AI051620 

highest scoring ESTs for S100PBP:

AI807668 AL042503 AA022470 AA023003 AA112172 AA232097 AA255911 AA256032 AA256293 AA256326 

Unigene Cluster for S100PBP:

S100P binding protein
Hs.440880  [show with all ESTs]
Unigene Representative Sequence: BX647916


GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for S100PBP (see all 9 )

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1:                    -     -           -                                         -     -     -                           
SP2:                          -           -                                         -     -     -                           
SP3:                                                                                -     -     -                           
SP4:                                                                                      -     -                           
SP5:        -     -     -     -           -                                                                                 

About this scheme

ECgene alternative splicing isoforms for S100PBP

4 Ensembl transcripts including schematic representations:
ENST00000356689  ENST00000398243  ENST00000373476  ENST00000373475  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100PBP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for S100PBP

1 / 2 / 3

6 probe-sets matching S100PBP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
51102_at2, 3 U95-B 1 1.00 1.00 0.97 1.10 AL042503 1.00 1.00 1.00 1
58246_at2, 3 U95-B 2 1.00 0.97 0.96 0.90 AI807668 1.00 1.00 1.00 1

222610_s_at2, 3 U133-B 1 1.00 1.00 -- -- T81452 0.60 1.00 0.82 1

218370_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022753 0.60 1.00 0.82 1

222610_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

218370_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  S100PBP for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTTTTTCCCT

SOURCE GeneReport for Unigene cluster: Hs.440880

UniProtKB/Swiss-Prot: S1PBP_HUMAN, Q96BU1
Tissue specificity: Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In
pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not
expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and
pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at
protein level). Not detected in non-neoplastic ductal epithelium (at protein level)

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for S100PBP gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
S100PBP1   -- S100P binding protein 86.49(n)
76.9(a)
478147  XM_535323.2  XP_535323.2 
chimpanzee
(Pan troglodytes)
S100PBP1   -- S100P binding protein 99.26(n)
99.26(a)
743131  XM_001164617.1  XP_001164617.1 
cow
(Bos taurus)
S100PBP1   -- S100P binding protein 84.78(n)
76.18(a)
539983  NM_001034687.1  NP_001029859.1 
mouse
(Mus musculus)
S100pbp1, 5 45
S100P binding protein1, 5 82.86(n)1
72.73(a)1
746481  NM_029036.21  NP_083312.11 
 AI4274375  AI8513435  (see all 17)
About this table        Species with no ortholog for S100PBP

ENSEMBL Gene Tree for S100PBP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/221 NCBI SNPs in S100PBP are shown (see all 221 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 58)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs12843651,2
A,F,H,O33096675(+) TGGTAC/GTGGGT 1 -- ut31 ese35Minor allele frequency- G:0.13MN EU EA WA 602
rs95001,2
A,C,F,H33096723(+) TCTCTC/TATATT 1 -- ut3115Minor allele frequency- T:0.36MN NS EU EA WA 1308
rs121268511,2
A,C,F,H33094383(+) CCATTG/ACCGAC 1 -- ut318Minor allele frequency- A:0.08EU EA WA 840
rs104492341,2
F,H33094658(+) TGTTAG/CATAAC 1 -- ut314Minor allele frequency- C:0.02EU EA WA 418
rs10463151,2
F33096678(+) TACTGG/AGTAGA 1 -- ut31 ese31Minor allele frequency- A:0.03MN 184
rs104492351,2
H33095989(+) AGAAAC/TGGACG 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 420
rs120923261,2
A,H33064788(+) GATTCG/ATCCAA 2 S/S syn1 ese34Minor allele frequency- A:0.00EU EA WA 420
--
rs49517881,2
A,C,F,H33061975(+) TATACG/ATTACG 2 -- int14Minor allele frequency- A:0.37EU EA WA 412
rs7852751,2
C,F,H,O33092290(+) AGATAC/TTcaaa 1 -- int15Minor allele frequency- T:0.17MN EU EA WA 602
rs49517741,2
A,C,F,H33087287(+) TCCTGA/GCTTTC 1 -- int14Minor allele frequency- G:0.31EU EA WA 418
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HapMap Linkage Disequilibrium images for S100PBP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611889

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for S100PBP gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 64766 HGNC: 25768 AceView: FLJ12903 Ensembl:ENSG00000116497 euGenes: HUgn64766
ECgene: S100PBP H-InvDB: S100PBP
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for S100PBP:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for S100PBP-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for S100PBP Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for S100PBP Browse small molecules at Sigma-Aldrich
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for S100PBP

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