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Aliases for S100PBP Gene

Aliases for S100PBP Gene

  • S100P Binding Protein 2 3 5
  • S100P Binding Protein 1 2 3
  • S100PBPR 3 4
  • S100P-Binding Protein Riken 4
  • S100P-Binding Protein 3

External Ids for S100PBP Gene

Previous GeneCards Identifiers for S100PBP Gene

  • GC01P032954
  • GC01P033055
  • GC01P033283
  • GC01P031399

Summaries for S100PBP Gene

Entrez Gene Summary for S100PBP Gene

  • This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

GeneCards Summary for S100PBP Gene

S100PBP (S100P Binding Protein) is a Protein Coding gene. Diseases associated with S100PBP include Pancreatic Ductal Adenocarcinoma and Adenocarcinoma. GO annotations related to this gene include calcium-dependent protein binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100PBP Gene

Genomics for S100PBP Gene

Regulatory Elements for S100PBP Gene

Enhancers for S100PBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around S100PBP on UCSC Golden Path with GeneCards custom track

Promoters for S100PBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for S100PBP Gene

32,816,767 bp from pter
32,858,879 bp from pter
42,113 bases
Plus strand

Genomic View for S100PBP Gene

Genes around S100PBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100PBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100PBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100PBP Gene

Proteins for S100PBP Gene

  • Protein details for S100PBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    S100P-binding protein
    Protein Accession:
    Secondary Accessions:
    • B3KR04
    • D3DPQ5
    • Q5HYH3
    • Q9H997

    Protein attributes for S100PBP Gene

    408 amino acids
    Molecular mass:
    45582 Da
    Quaternary structure:
    • Interacts with S100P.
    • Sequence=BAB14335.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for S100PBP Gene


neXtProt entry for S100PBP Gene

Post-translational modifications for S100PBP Gene

  • Ubiquitination at Lys 305 and Lys 322
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for S100PBP Gene

Domains & Families for S100PBP Gene

Protein Domains for S100PBP Gene


Suggested Antigen Peptide Sequences for S100PBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with S100PBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for S100PBP Gene

Function for S100PBP Gene

Gene Ontology (GO) - Molecular Function for S100PBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048306 calcium-dependent protein binding IPI 15632002
genes like me logo Genes that share ontologies with S100PBP: view
genes like me logo Genes that share phenotypes with S100PBP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100PBP Gene

Localization for S100PBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100PBP Gene

Nucleus. Note=Colocalizes with S100P in the nucleus. {ECO:0000269 PubMed:15632002}.

Subcellular locations from

Jensen Localization Image for S100PBP Gene COMPARTMENTS Subcellular localization image for S100PBP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for S100PBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15632002
genes like me logo Genes that share ontologies with S100PBP: view

Pathways & Interactions for S100PBP Gene

SuperPathways for S100PBP Gene

No Data Available

Interacting Proteins for S100PBP Gene

Gene Ontology (GO) - Biological Process for S100PBP Gene


No data available for Pathways by source and SIGNOR curated interactions for S100PBP Gene

Drugs & Compounds for S100PBP Gene

No Compound Related Data Available

Transcripts for S100PBP Gene

Unigene Clusters for S100PBP Gene

S100P binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100PBP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: -
SP8: -

Relevant External Links for S100PBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100PBP Gene

mRNA expression in normal human tissues for S100PBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for S100PBP Gene

This gene is overexpressed in Cervix (34.4) and Adrenal (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100PBP Gene

Protein tissue co-expression partners for S100PBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100PBP Gene:


SOURCE GeneReport for Unigene cluster for S100PBP Gene:


mRNA Expression by UniProt/SwissProt for S100PBP Gene:

Tissue specificity: Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).
genes like me logo Genes that share expression patterns with S100PBP: view

Primer Products

No data available for mRNA differential expression in normal tissues for S100PBP Gene

Orthologs for S100PBP Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100PBP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia S100PBP 34
  • 85.19 (n)
  • 76.18 (a)
S100PBP 35
  • 72 (a)
(Canis familiaris)
Mammalia S100PBP 34
  • 86.49 (n)
  • 76.9 (a)
S100PBP 35
  • 74 (a)
(Mus musculus)
Mammalia S100pbp 34
  • 82.86 (n)
  • 72.73 (a)
S100pbp 16
S100pbp 35
  • 70 (a)
(Pan troglodytes)
Mammalia S100PBP 34
  • 99.26 (n)
  • 99.26 (a)
S100PBP 35
  • 99 (a)
(Rattus norvegicus)
Mammalia S100pbp 34
  • 82.42 (n)
  • 73.51 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
-- 35
  • 47 (a)
Species where no ortholog for S100PBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100PBP Gene

Gene Tree for S100PBP (if available)
Gene Tree for S100PBP (if available)

Paralogs for S100PBP Gene

No data available for Paralogs for S100PBP Gene

Variants for S100PBP Gene

Sequence variations from dbSNP and Humsavar for S100PBP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9500 -- 32,858,535(+) TCTCT(C/T)ATATT nc-transcript-variant, utr-variant-3-prime
rs702833 -- 32,848,596(+) GGTCA(C/T)GTGCC intron-variant
rs702834 -- 32,848,695(+) TATCC(A/G)TCCTC intron-variant
rs702835 -- 32,852,239(+) accca(A/G)gaggc intron-variant
rs702836 -- 32,852,960(+) ATAAT(A/C/T)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100PBP Gene

Variant ID Type Subtype PubMed ID
esv3577803 CNV loss 25503493
nsv1145333 CNV deletion 24896259
nsv516302 CNV loss 19592680

Variation tolerance for S100PBP Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100PBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100PBP Gene

Disorders for S100PBP Gene

MalaCards: The human disease database

(2) MalaCards diseases for S100PBP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
  • adenocarcinoma nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100PBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with S100PBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100PBP Gene

Publications for S100PBP Gene

  1. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. (PMID: 15632002) Dowen S.E. … Lemoine N.R. (Am. J. Pathol. 2005) 3 4 22 65
  2. Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. (PMID: 18089492) Deng H. … Lin F. (Am. J. Clin. Pathol. 2008) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 65

Products for S100PBP Gene

Sources for S100PBP Gene

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