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Aliases for S100P Gene

Aliases for S100P Gene

  • S100 Calcium Binding Protein P 2 3 5
  • Migration-Inducing Gene 9 Protein 3 4
  • S100 Calcium-Binding Protein P 2 4
  • Protein S100-E 3 4
  • MIG9 3 4
  • Protein S100-P 3
  • S100E 4

External Ids for S100P Gene

Previous GeneCards Identifiers for S100P Gene

  • GC04M006590
  • GC04P006816
  • GC04P006687
  • GC04P006759
  • GC04P006812
  • GC04P006695
  • GC04P006628
  • GC04P006696
  • GC04P006698

Summaries for S100P Gene

Entrez Gene Summary for S100P Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100P Gene

S100P (S100 Calcium Binding Protein P) is a Protein Coding gene. Diseases associated with S100P include Bile Duct Carcinoma. Among its related pathways are Immune System and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A1.

UniProtKB/Swiss-Prot for S100P Gene

  • May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

Gene Wiki entry for S100P Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100P Gene

Genomics for S100P Gene

Regulatory Elements for S100P Gene

Enhancers for S100P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F006687 0.9 ENCODE 57.2 -0.4 -357 9.9 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 S100P BLOC1S4 LOC93622 LOC105374366 ENSG00000279859 LOC339988
GH04F006664 0.2 Ensembl 11.6 -28.2 -28225 0.3 SRF CTCF ZNF687 NRF1 ZNF384 REST HDAC8 RAD21 CTBP1 GABPB1 MRFAP1 MRFAP1L1 BLOC1S4 LOC339988 S100P KIAA0232 LOC93622 GC04P006646
GH04F006663 0.6 Ensembl 11.6 -28.9 -28862 0.8 CTCF REST MNT RAD21 GABPB1 RCOR1 KDM1A ZBTB33 ZNF18 LOC105374366 LOC93622 MRFAP1 MRFAP1L1 BLOC1S4 LOC339988 S100P KIAA0232 GC04P006646
GH04F006672 0.7 ENCODE 9 -18.6 -18560 3.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC105374366 BLOC1S4 LOC93622 MRFAP1L1 KIAA0232 S100P LOC339988
GH04F006708 0.6 ENCODE 7.5 +16.3 16348 2.8 ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF48 ETS1 YY1 MRFAP1L1 S100P LOC93622 ENSG00000282742
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around S100P on UCSC Golden Path with GeneCards custom track

Promoters for S100P Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001857365 1731 401 ZNF639 PAF1 SMAD5 HLF SIN3A KLF4 GATA3 GATA2 POLR2A MYNN

Genomic Location for S100P Gene

Chromosome:
4
Start:
6,693,069 bp from pter
End:
6,697,170 bp from pter
Size:
4,102 bases
Orientation:
Plus strand

Genomic View for S100P Gene

Genes around S100P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100P Gene

Proteins for S100P Gene

  • Protein details for S100P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25815-S100P_HUMAN
    Recommended name:
    Protein S100-P
    Protein Accession:
    P25815
    Secondary Accessions:
    • Q5J7W2

    Protein attributes for S100P Gene

    Size:
    95 amino acids
    Molecular mass:
    10400 Da
    Quaternary structure:
    • Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    Miscellaneous:
    • This protein binds two calcium ions.
    SequenceCaution:
    • Sequence=AAS00487.1; Type=Miscellaneous discrepancy; Note=Sequencing error in Met-1 codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100P Gene

neXtProt entry for S100P Gene

Post-translational modifications for S100P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100P Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for S100P (S100P)
  • Santa Cruz Biotechnology (SCBT) Antibodies for S100P

No data available for DME Specific Peptides for S100P Gene

Domains & Families for S100P Gene

Suggested Antigen Peptide Sequences for S100P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25815

UniProtKB/Swiss-Prot:

S100P_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100P: view

Function for S100P Gene

Molecular function for S100P Gene

GENATLAS Biochemistry:
S100 calcium binding protein P
UniProtKB/Swiss-Prot Function:
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

Gene Ontology (GO) - Molecular Function for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding TAS 15632002
GO:0005509 calcium ion binding IEA,TAS --
GO:0005515 protein binding IPI 12042313
GO:0046872 metal ion binding IEA --
GO:0048306 calcium-dependent protein binding IPI 15632002
genes like me logo Genes that share ontologies with S100P: view
genes like me logo Genes that share phenotypes with S100P: view

Animal Model Products

miRNA for S100P Gene

miRTarBase miRNAs that target S100P

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100P Gene

Localization for S100P Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100P Gene

Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100P Gene COMPARTMENTS Subcellular localization image for S100P gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15632002
GO:0005737 cytoplasm IDA,TAS 15632002
GO:0005886 plasma membrane IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with S100P: view

Pathways & Interactions for S100P Gene

genes like me logo Genes that share pathways with S100P: view

Pathways by source for S100P Gene

1 Cell Signaling Technology pathway for S100P Gene
1 BioSystems pathway for S100P Gene
2 Reactome pathways for S100P Gene

Gene Ontology (GO) - Biological Process for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010033 response to organic substance IEP 17486081
GO:0043542 endothelial cell migration IMP 15313892
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with S100P: view

No data available for SIGNOR curated interactions for S100P Gene

Drugs & Compounds for S100P Gene

(2) Drugs for S100P Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cromoglicic acid Approved Pharma Target, antagonist 0
calcium Nutra 0
genes like me logo Genes that share compounds with S100P: view

Transcripts for S100P Gene

mRNA/cDNA for S100P Gene

Unigene Clusters for S100P Gene

S100 calcium binding protein P:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100P Gene

No ASD Table

Relevant External Links for S100P Gene

GeneLoc Exon Structure for
S100P
ECgene alternative splicing isoforms for
S100P

Expression for S100P Gene

mRNA expression in normal human tissues for S100P Gene

mRNA differential expression in normal tissues according to GTEx for S100P Gene

This gene is overexpressed in Whole Blood (x17.4), Bladder (x10.6), Stomach (x9.6), and Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for S100P Gene

This gene is overexpressed in Nasal epithelium (28.7), Placenta (10.3), and Breast (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100P Gene



NURSA nuclear receptor signaling pathways regulating expression of S100P Gene:

S100P

SOURCE GeneReport for Unigene cluster for S100P Gene:

Hs.2962

mRNA Expression by UniProt/SwissProt for S100P Gene:

P25815-S100P_HUMAN
Tissue specificity: Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.
genes like me logo Genes that share expression patterns with S100P: view

Primer Products

No data available for Protein tissue co-expression partners for S100P Gene

Orthologs for S100P Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100P 34 35
  • 98.6 (n)
dog
(Canis familiaris)
Mammalia S100P 34 35
  • 81.56 (n)
oppossum
(Monodelphis domestica)
Mammalia S100P 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s100p 34
  • 69.29 (n)
zebrafish
(Danio rerio)
Actinopterygii icn 35
  • 44 (a)
OneToMany
icn2 35
  • 42 (a)
OneToMany
s100t 35
  • 38 (a)
OneToMany
s100s 35
  • 36 (a)
OneToMany
Species where no ortholog for S100P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100P Gene

ENSEMBL:
Gene Tree for S100P (if available)
TreeFam:
Gene Tree for S100P (if available)

Paralogs for S100P Gene

(20) SIMAP similar genes for S100P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100P: view

Variants for S100P Gene

Sequence variations from dbSNP and Humsavar for S100P Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10009150 -- 6,692,083(+) tacat(A/G)tgtgt upstream-variant-2KB
rs10019431 -- 6,692,171(+) TGTGT(A/G)TATAT upstream-variant-2KB
rs10019716 -- 6,692,436(+) AAGCC(A/G)GCTCT upstream-variant-2KB
rs10674854 -- 6,697,541(+) TATTT(-/ATTT)TTGAG downstream-variant-500B
rs10937750 -- 6,695,033(+) gatca(C/T)ggctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100P Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER inversion 12058347
nsv829849 CNV loss 17160897

Variation tolerance for S100P Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100P Gene

Disorders for S100P Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100P Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bile duct carcinoma
  • carcinoma of extrahepatic bile duct
- elite association - COSMIC cancer census association via MalaCards
Search S100P in MalaCards View complete list of genes associated with diseases

Relevant External Links for S100P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100P
genes like me logo Genes that share disorders with S100P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100P Gene

Publications for S100P Gene

  1. Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein. (PMID: 14672411) Jin G. … Mao Y. (Mol. Biol. Rep. 2003) 3 4 22 64
  2. Generation and characterization of a novel, permanently active S100P mutant. (PMID: 19111582) Austermann J. … Gerke V. (Biochim. Biophys. Acta 2009) 3 4 64
  3. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. (PMID: 15632002) Dowen S.E. … Lemoine N.R. (Am. J. Pathol. 2005) 3 4 64
  4. S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). (PMID: 14617629) Arumugam T. … Logsdon C.D. (J. Biol. Chem. 2004) 3 4 64
  5. Heterodimeric interaction and interfaces of S100A1 and S100P. (PMID: 15171681) Wang G. … Barraclough R. (Biochem. J. 2004) 3 4 64

Products for S100P Gene

Sources for S100P Gene

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