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Aliases for S100P Gene

Aliases for S100P Gene

  • S100 Calcium Binding Protein P 2 3
  • S100 Calcium-Binding Protein P 2 3 4
  • Migration-Inducing Gene 9 Protein 3 4
  • Protein S100-E 3 4
  • MIG9 3 4
  • Protein S100-P 3
  • S100E 4

External Ids for S100P Gene

Summaries for S100P Gene

Entrez Gene Summary for S100P Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100P Gene

S100P (S100 Calcium Binding Protein P) is a Protein Coding gene. Diseases associated with S100P include parachordoma and prostate cancer. Among its related pathways are Ca, cAMP and Lipid Signaling and Gastric cancer network 1. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100P Gene

  • May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

Gene Wiki entry for S100P Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100P Gene

Genomics for S100P Gene

Genomic Location for S100P Gene

Start:
6,693,069 bp from pter
End:
6,697,170 bp from pter
Size:
4,102 bases
Orientation:
Plus strand

Genomic View for S100P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100P Gene

Regulatory Elements for S100P Gene

Proteins for S100P Gene

  • Protein details for S100P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25815-S100P_HUMAN
    Recommended name:
    Protein S100-P
    Protein Accession:
    P25815
    Secondary Accessions:
    • Q5J7W2

    Protein attributes for S100P Gene

    Size:
    95 amino acids
    Molecular mass:
    10400 Da
    Quaternary structure:
    • Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    Miscellaneous:
    • This protein binds two calcium ions
    SequenceCaution:
    • Sequence=AAS00487.1; Type=Miscellaneous discrepancy; Note=Sequencing error in Met-1 codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100P Gene

neXtProt entry for S100P Gene

Proteomics data for S100P Gene at MOPED

Post-translational modifications for S100P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100P Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100P Gene

Domains for S100P Gene

Gene Families for S100P Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

Suggested Antigen Peptide Sequences for S100P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25815

UniProtKB/Swiss-Prot:

S100P_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • P25815
Family:
  • Belongs to the S-100 family.:
    • P25815
genes like me logo Genes that share domains with S100P: view

Function for S100P Gene

Molecular function for S100P Gene

GENATLAS Biochemistry: S100 calcium binding protein P
UniProtKB/Swiss-Prot Function: May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

Gene Ontology (GO) - Molecular Function for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding TAS 15632002
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12042313
GO:0048306 calcium-dependent protein binding IPI 15632002
GO:0050786 RAGE receptor binding IEA --
genes like me logo Genes that share ontologies with S100P: view

Phenotypes for S100P Gene

GenomeRNAi human phenotypes for S100P:
genes like me logo Genes that share phenotypes with S100P: view

miRNA for S100P Gene

miRTarBase miRNAs that target S100P

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for S100P Gene

Localization for S100P Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100P Gene

Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100P Gene COMPARTMENTS Subcellular localization image for S100P gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15632002
GO:0005737 cytoplasm TAS 15632002
GO:0005886 plasma membrane --
GO:0031528 microvillus membrane IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with S100P: view

Pathways for S100P Gene

genes like me logo Genes that share pathways with S100P: view

Pathways by source for S100P Gene

1 Cell Signaling Technology pathway for S100P Gene
1 BioSystems pathway for S100P Gene

Gene Ontology (GO) - Biological Process for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010033 response to organic substance IEP 17486081
GO:0043542 endothelial cell migration IMP 15313892
genes like me logo Genes that share ontologies with S100P: view

Compounds for S100P Gene

(1) HMDB Compounds for S100P Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for S100P Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cromoglicic acid
  • Acide Cromoglicique [INN-French]
16110-51-3 target antagonist
genes like me logo Genes that share compounds with S100P: view

Transcripts for S100P Gene

mRNA/cDNA for S100P Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(179) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100P Gene

S100 calcium binding protein P:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100P Gene

No ASD Table

Relevant External Links for S100P Gene

GeneLoc Exon Structure for
S100P
ECgene alternative splicing isoforms for
S100P

Expression for S100P Gene

mRNA expression in normal human tissues for S100P Gene

mRNA differential expression in normal tissues according to GTEx for S100P Gene

This gene is overexpressed in Whole Blood (17.4), Bladder (10.6), Stomach (9.6), and Esophagus - Mucosa (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100P Gene

SOURCE GeneReport for Unigene cluster for S100P Gene Hs.2962

mRNA Expression by UniProt/SwissProt for S100P Gene

P25815-S100P_HUMAN
Tissue specificity: Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.
genes like me logo Genes that share expressions with S100P: view

Orthologs for S100P Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100P 35
  • 98.6 (n)
  • 98.95 (a)
S100P 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100P 35
  • 81.56 (n)
  • 81.91 (a)
S100P 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100P 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s100p 35
  • 69.29 (n)
  • 67.42 (a)
zebrafish
(Danio rerio)
Actinopterygii icn 36
  • 44 (a)
OneToMany
icn2 36
  • 42 (a)
OneToMany
s100s 36
  • 36 (a)
OneToMany
s100t 36
  • 38 (a)
OneToMany
Species with no ortholog for S100P:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100P Gene

ENSEMBL:
Gene Tree for S100P (if available)
TreeFam:
Gene Tree for S100P (if available)

Paralogs for S100P Gene

Selected SIMAP similar genes for S100P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100P: view

Variants for S100P Gene

Sequence variations from dbSNP and Humsavar for S100P Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4712 -- 6,694,046(+) ATGGA(G/T)AAGGA reference, missense
rs3822260 -- 6,696,095(-) GGAAA(A/G)AAACA intron-variant
rs3822261 -- 6,696,068(-) AAACA(G/T)ATCAT intron-variant
rs3822262 -- 6,696,039(-) TGTGC(A/C)TGAAG intron-variant
rs3822263 -- 6,695,946(-) ATGTC(A/G)CAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100P Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv829849 CNV Loss 17160897

Relevant External Links for S100P Gene

HapMap Linkage Disequilibrium report
S100P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100P Gene

Disorders for S100P Gene

(2) University of Copenhagen DISEASES for S100P Gene

genes like me logo Genes that share disorders with S100P: view

No data available for UniProtKB/Swiss-Prot for S100P Gene

Publications for S100P Gene

  1. Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein. (PMID: 14672411) Jin G. … Mao Y. (Mol. Biol. Rep. 2003) 3 4 23
  2. Conformational and thermodynamic properties of peptide binding to the human S100P protein. (PMID: 12021435) Gribenko A.V. … Makhatadze G.I. (Protein Sci. 2002) 3 23
  3. The crystal structure at 2A resolution of the Ca2+ -binding protein S100P. (PMID: 12507480) Zhang H. … Rao Z. (J. Mol. Biol. 2003) 3 4
  4. Purification and characterization of a new member of the S-100 protein family from human placenta. (PMID: 1540168) Emoto Y. … Hidaka H. (Biochem. Biophys. Res. Commun. 1992) 3 4
  5. S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. (PMID: 1633809) Becker T. … Weber K. (Eur. J. Biochem. 1992) 3 4

Products for S100P Gene

Sources for S100P Gene

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