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Aliases for S100G Gene

Aliases for S100G Gene

  • S100 Calcium Binding Protein G 2 3 5
  • Calbindin-D9K 2 3 4
  • Calbindin 3, (Vitamin D-Dependent Calcium-Binding Protein) 2 3
  • Vitamin D-Dependent Calcium-Binding Protein, Intestinal 3 4
  • S100 Calcium-Binding Protein G 3 4
  • CABP9K 3 4
  • CALB3 3 4
  • CABP 3 4
  • Calbindin D9K 3
  • CaBP1 3
  • S100D 4

External Ids for S100G Gene

Previous HGNC Symbols for S100G Gene

  • CALB3

Previous GeneCards Identifiers for S100G Gene

  • GC0XP016427
  • GC0XP016578
  • GC0XP014422

Summaries for S100G Gene

Entrez Gene Summary for S100G Gene

  • This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100G Gene

S100G (S100 Calcium Binding Protein G) is a Protein Coding gene. Diseases associated with S100G include Spinocerebellar Ataxia 1. Among its related pathways are Mineral absorption. GO annotations related to this gene include calcium ion binding and vitamin D binding.

Gene Wiki entry for S100G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100G Gene

Genomics for S100G Gene

Regulatory Elements for S100G Gene

Enhancers for S100G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around S100G on UCSC Golden Path with GeneCards custom track

Genomic Location for S100G Gene

Chromosome:
X
Start:
16,650,158 bp from pter
End:
16,654,670 bp from pter
Size:
4,513 bases
Orientation:
Plus strand

Genomic View for S100G Gene

Genes around S100G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100G Gene

Proteins for S100G Gene

  • Protein details for S100G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29377-S100G_HUMAN
    Recommended name:
    Protein S100-G
    Protein Accession:
    P29377
    Secondary Accessions:
    • Q5JS49

    Protein attributes for S100G Gene

    Size:
    79 amino acids
    Molecular mass:
    9016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for S100G Gene

Proteomics data for S100G Gene at MOPED

Post-translational modifications for S100G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100G Gene

Domains & Families for S100G Gene

Suggested Antigen Peptide Sequences for S100G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29377

UniProtKB/Swiss-Prot:

S100G_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100G: view

Function for S100G Gene

genes like me logo Genes that share phenotypes with S100G: view

Human Phenotype Ontology for S100G Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for S100G Gene

MGI Knock Outs for S100G:

Animal Model Products

miRNA for S100G Gene

miRTarBase miRNAs that target S100G

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for S100G Gene

Localization for S100G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100G Gene COMPARTMENTS Subcellular localization image for S100G gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for S100G Gene

Pathways & Interactions for S100G Gene

SuperPathways for S100G Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with S100G: view

Pathways by source for S100G Gene

1 KEGG pathway for S100G Gene

Interacting Proteins for S100G Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369547%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000369547 for S100G Gene via STRING

Symbol External ID(s) Details
BAG3

Gene Ontology (GO) - Biological Process for S100G Gene

None

No data available for SIGNOR curated interactions for S100G Gene

Drugs & Compounds for S100G Gene

(12) Drugs for S100G Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Formylmethionine Experimental Pharma Target 0

(9) Additional Compounds for S100G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100G: view

Transcripts for S100G Gene

mRNA/cDNA for S100G Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for S100G Gene

No ASD Table

Relevant External Links for S100G Gene

GeneLoc Exon Structure for
S100G
ECgene alternative splicing isoforms for
S100G

Expression for S100G Gene

mRNA expression in normal human tissues for S100G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x43.8).

Protein differential expression in normal tissues from HIPED for S100G Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S100G Gene



SOURCE GeneReport for Unigene cluster for S100G Gene Hs.639

genes like me logo Genes that share expression patterns with S100G: view

Protein tissue co-expression partners for S100G Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for S100G Gene

Orthologs for S100G Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100G Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia S100G 35
  • 88.19 (n)
  • 92.41 (a)
S100G 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100g 35
  • 77.64 (n)
  • 74.68 (a)
S100g 16
S100g 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100G 35
  • 100 (n)
  • 100 (a)
S100G 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100g 35
  • 80.17 (n)
  • 78.48 (a)
cow
(Bos Taurus)
Mammalia S100G 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100G 36
  • 78 (a)
OneToOne
Species with no ortholog for S100G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100G Gene

ENSEMBL:
Gene Tree for S100G (if available)
TreeFam:
Gene Tree for S100G (if available)

Paralogs for S100G Gene

(16) SIMAP similar genes for S100G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100G: view

No data available for Paralogs for S100G Gene

Variants for S100G Gene

Structural Variations from Database of Genomic Variants (DGV) for S100G Gene

Variant ID Type Subtype PubMed ID
nsv6816 CNV Insertion 18451855

Variation tolerance for S100G Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for S100G Gene

Disorders for S100G Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100G Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 1
  • spinocerebellar ataxia type 1
- elite association - COSMIC cancer census association via MalaCards
Search S100G in MalaCards View complete list of genes associated with diseases

Relevant External Links for S100G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100G
genes like me logo Genes that share disorders with S100G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100G Gene

Publications for S100G Gene

  1. Molecular cloning and chromosomal assignment of human calbindin- D9k. (PMID: 1610358) Howard A. … Walters J.R.I. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Molecular cloning of the full-length cDNA encoding the human calbindin-D9k. (PMID: 1379540) Jeung E.B. … Leung P.C.K. (FEBS Lett. 1992) 2 3 23
  3. [Effect of parathyroid hormone and 1,25-(OH)2-D3 on the expression of the mRNA of calbindin D9k in Caco-2 cells]. (PMID: 17712966) Mao X. … Huo Z. (Wei Sheng Yan Jiu 2007) 3 23
  4. Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. (PMID: 15217781) Wang L. … Fleet J.C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2004) 3 23
  5. Factors involved in the duodenal expression of the human calbindin-D9k gene. (PMID: 10417310) Barley N.F. … Walters J.R. (Biochem. J. 1999) 3 23

Products for S100G Gene

Sources for S100G Gene

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