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Aliases for S100G Gene

Aliases for S100G Gene

  • S100 Calcium Binding Protein G 2 3
  • Calbindin-D9K 2 3 4
  • CABP9K 3 4 6
  • CALB3 3 4 6
  • Calbindin 3, (Vitamin D-Dependent Calcium-Binding Protein) 2 3
  • Vitamin D-Dependent Calcium-Binding Protein, Intestinal 3 4
  • S100 Calcium-Binding Protein G 3 4
  • CABP 3 4
  • Protein S100-G 3
  • Calbindin D9K 3
  • CABP1 3
  • S100D 4

External Ids for S100G Gene

Previous HGNC Symbols for S100G Gene

  • CALB3

Previous GeneCards Identifiers for S100G Gene

  • GC0XP016427
  • GC0XP016578
  • GC0XP014422

Summaries for S100G Gene

Entrez Gene Summary for S100G Gene

  • This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100G Gene

S100G (S100 Calcium Binding Protein G) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods and Mineral absorption. GO annotations related to this gene include calcium ion binding and vitamin D binding.

Gene Wiki entry for S100G Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100G Gene

Genomics for S100G Gene

Regulatory Elements for S100G Gene

Genomic Location for S100G Gene

16,650,158 bp from pter
16,654,670 bp from pter
4,513 bases
Plus strand

Genomic View for S100G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100G Gene

Proteins for S100G Gene

  • Protein details for S100G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-G
    Protein Accession:
    Secondary Accessions:
    • Q5JS49

    Protein attributes for S100G Gene

    79 amino acids
    Molecular mass:
    9016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for S100G Gene

Proteomics data for S100G Gene at MOPED

Post-translational modifications for S100G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100G Gene

Domains for S100G Gene

Suggested Antigen Peptide Sequences for S100G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100G: view

Function for S100G Gene

Gene Ontology (GO) - Molecular Function for S100G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005499 vitamin D binding IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with S100G: view

Phenotypes for S100G Gene

MGI mutant phenotypes for S100G:
inferred from 2 alleles
GenomeRNAi human phenotypes for S100G:
genes like me logo Genes that share phenotypes with S100G: view

Animal Models for S100G Gene

MGI Knock Outs for S100G:

miRNA for S100G Gene

miRTarBase miRNAs that target S100G

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S100G

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for S100G Gene

Localization for S100G Gene

Subcellular locations from

Jensen Localization Image for S100G Gene COMPARTMENTS Subcellular localization image for S100G gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for S100G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with S100G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for S100G Gene

Pathways for S100G Gene

genes like me logo Genes that share pathways with S100G: view

Pathways by source for S100G Gene

1 Qiagen pathway for S100G Gene
1 KEGG pathway for S100G Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for S100G Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369547 for S100G Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for S100G Gene


Drugs for S100G Gene

(1) Drugbank Compounds for S100G Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
439750 Target experimental

(20) Novoseek inferred chemical compound relationships for S100G Gene

Compound -log(P) Hits PubMed IDs
1,25 dihydroxy vitamin d3 69.4 7
calcium 67.3 102
vitamin d 65.2 15
intron a 56.6 3
calcitriol 54.5 6
genes like me logo Genes that share compounds with S100G: view

Transcripts for S100G Gene

mRNA/cDNA for S100G Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S100G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100G Gene

No ASD Table

Relevant External Links for S100G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100G Gene

mRNA expression in normal human tissues for S100G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (43.8).

Protein differential expression in normal tissues for S100G Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for S100G Gene

SOURCE GeneReport for Unigene cluster for S100G Gene Hs.639

genes like me logo Genes that share expressions with S100G: view

Expression partners for S100G Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for S100G Gene

Orthologs for S100G Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100G Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia S100G 35
  • 88.19 (n)
  • 92.41 (a)
S100G 36
  • 65 (a)
(Mus musculus)
Mammalia S100g 35
  • 77.64 (n)
  • 74.68 (a)
S100g 16
S100g 36
  • 75 (a)
(Pan troglodytes)
Mammalia S100G 35
  • 100 (n)
  • 100 (a)
S100G 36
  • 100 (a)
(Rattus norvegicus)
Mammalia S100g 35
  • 80.17 (n)
  • 78.48 (a)
(Bos Taurus)
Mammalia S100G 36
  • 89 (a)
(Monodelphis domestica)
Mammalia S100G 36
  • 78 (a)
Species with no ortholog for S100G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100G Gene

Gene Tree for S100G (if available)
Gene Tree for S100G (if available)

Paralogs for S100G Gene

(16) SIMAP similar genes for S100G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100G: view

No data available for Paralogs for S100G Gene

Variants for S100G Gene

Structural Variations from Database of Genomic Variants (DGV) for S100G Gene

Variant ID Type Subtype PubMed ID
nsv6816 CNV Insertion 18451855

Relevant External Links for S100G Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for S100G Gene

Disorders for S100G Gene

(2) University of Copenhagen DISEASES for S100G Gene

(4) Novoseek inferred disease relationships for S100G Gene

Disease -log(P) Hits PubMed IDs
epilepsy temporal lobe 10.6 1
senile plaques 8.52 1
tumors 1.07 2
parkinson disease 0 3
genes like me logo Genes that share disorders with S100G: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for S100G Gene

Publications for S100G Gene

  1. Molecular cloning of the full-length cDNA encoding the human calbindin-D9k. (PMID: 1379540) Jeung E.B. … Leung P.C.K. (FEBS Lett. 1992) 2 3 4 23
  2. Molecular cloning and chromosomal assignment of human calbindin- D9k. (PMID: 1610358) Howard A. … Walters J.R.I. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  3. Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues. (PMID: 2009668) Balmain N. (Clin. Orthop. Relat. Res. 1991) 3 23
  4. Calbindin-D9K gene expression in human myometrium during pregnancy and labor. (PMID: 8045984) Miller E.K. … Iacopino A.M. (J. Clin. Endocrinol. Metab. 1994) 3 23
  5. Factors involved in the duodenal expression of the human calbindin-D9k gene. (PMID: 10417310) Barley N.F. … Walters J.R. (Biochem. J. 1999) 3 23

Products for S100G Gene

Sources for S100G Gene

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