S100G Gene
protein-coding GIFtS : 54
GCID: GC0X P016668
S100 calcium binding protein G (Previous names: calbindin 3, (vitamin D-dependent calcium-binding protein)... ) (Previous symbol: CALB3 )
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Aliasesfor S100G gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases S100 Calcium Binding Protein G 1 2 S100 Calcium-Binding Protein G2 3 CABP9K1 2 3 5 Calbindin D9K2 CALB31 2 3 5 Calbindin-D9K1 CABP11 2 Protein S100-G2 Calbindin 3, (Vitamin D-Dependent Calcium-Binding Protein)1 2 Calbindin-D9k3 Vitamin D-Dependent Calcium-Binding Protein, Intestinal2 3 S100D3 CABP2 3
Export aliases for S100G gene to outside databases Previous GC identifers: GC0XP016427 GC0XP016578 GC0XP014422
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Summariesfor S100G gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for S100G : This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. (provided by RefSeq, Jul 2008) Gene Wiki entry for S100G
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Genomic Viewsfor S100G gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_167197.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the S100G gene promoter: POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a c-Myb POU2F2B Other transcription factors Search SABiosciences Chromatin IP Primers for S100G Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100G
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.2 S100G Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP016668: view genomic region
(about GC identifiers )
Start:
16,668,281 bp from pter
End:
16,672,793 bp from pter
Size:
4,513 bases
Orientation:
plus strand
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Proteinsfor S100G gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S100G_HUMAN, P29377 (See
protein sequence )Recommended Name: Protein S100-G Size : 79 amino acids; 9016 Da
Secondary accessions : Q5JS49Explore the universe of human proteins at neXtProt for S100G: NX_P29377 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P29377 S100G Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_004048.1 ENSEMBL proteins: ENSP00000369547 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016323 basolateral plasma membrane
IEA -- GO:0016324 apical plasma membrane
IEA --
S100G for ontologies About GeneDecksing S100G Antibody Products: Assay Products for S100G:
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Protein
Domains / Familiesfor S100G gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
S100G for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry P29377 ProtoNet protein and cluster: P29377
1 Blocks protein family : IPB001751 Calcium-binding protein UniProtKB/Swiss-Prot: S100G_HUMAN, P29377 Similarity : Belongs to the S-100 familySimilarity : Contains 2 EF-hand domains
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Functionfor S100G gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for S100G (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for S100GOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: S100G (NM_004057 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100G Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat S100G
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100G
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005499 vitamin D binding
IEA -- GO:0005509 calcium ion binding
IEA --
S100G for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for S100G :Animal Models: Mouse knock-out S100g tm1Ebje for S100G 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for S100g) :
S100G for phenotypes About GeneDecksing
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Pathways & Interactionsfor S100G gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Mineral absorption
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for S100G) :
S100G for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S100G
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Drugs & Compoundsfor S100G gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
S100G for compounds About GeneDecksing Browse Tocris compounds for S100G 1 DrugBank Compound for S100G About this table 10/20 Novoseek chemical compound relationships for S100G gene (see all 20 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
1,25 dihydroxy vitamin d3
69.4
8
1829088 (1), 7593254 (1), 8915780 (1), 9731705 (1) (see all 7 )
calcium
67.3
148
12810153 (4), 8389885 (4), 8395333 (4), 1539638 (3) (see all 68 )
vitamin d
65.2
19
2009668 (3), 2072223 (2), 9731705 (1), 11545681 (1) (see all 12 )
intron a
56.6
3
7711170 (2), 7598905 (1)
calcitriol
54.5
9
7816252 (4), 10198340 (1), 12181175 (1)
quin2
50.5
1
2193686 (1)
p-mca
46.2
5
12181175 (2), 12597618 (2)
amide
43.2
2
2166565 (1), 17536784 (1)
gaba
15.9
10
15269970 (2), 8276998 (1), 15590911 (1), 15236231 (1)
estrogen
15.7
10
8698870 (1), 7598905 (1), 19017814 (1), 7711170 (1) (see all 5 )
Search CenterWatch for drugs/clinical trials and news about S100G
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Transcriptsfor S100G gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for S100G gene: NM_004057.2 Unigene Cluster for S100G:
S100 calcium binding protein G Hs.639 Unigene Representative Sequence: L13220 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000380200 (uc004cxn.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for S100G (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for S100GOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: S100G (NM_004057 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100G Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat S100G
Additional cDNA sequence: BC112174.1 L13220.1 X65869.1
1 DOTS entry : DT.406357
3 AceView cDNA sequences :
L13220 NM_004057 X65869 GeneLoc Exon Structure
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Expression for S100G gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section S100G expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image S100G expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Inner Nuclear Layer Cholinergic Amacrine Cells Amacrine, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See S100G Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for S100G SOURCE GeneReport for Unigene cluster: Hs.639 SABiosciences Expression via Pathway-Focused PCR Array including S100G : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for S100GBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat S100G QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat S100G QIAGEN QuantiFast Probe-based Assays in human , mouse , rat S100G In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100G
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Orthologsfor S100G gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for S100G gene from 1/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for S100G (if available)TreeFam Gene Tree for S100G (if available)
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Paralogsfor S100G gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor S100G gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for S100G (16668281 - 16672793 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for S100G: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing S100G
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Disorders
/ Diseasesfor S100G gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
S100G for disorders About GeneDecksing
OMIM gene information: 302020
OMIM disorders : --18 diseases for S100G : About MalaCards duodenitis duodenum cancer spinocerebellar ataxia osteomalacia parkinson's disease rickets down syndrome neurologic diseases leiomyoma choriocarcinoma ataxia dementia cerebritis retinitis thyroiditis adenocarcinoma hepatitis neuronitis 2 diseases from the University of Copenhagen DISEASES database for S100G :Duodenum cancer Rickets 4 Novoseek disease relationships for S100G gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsy temporal lobe
10.6
1
1865007 (1)
senile plaques
8.52
1
2142259 (1)
tumors
1.07
2
8698870 (1), 11912242 (1)
parkinson disease
0
3
11086288 (2), 8358501 (1)
Export disorders for S100G gene to outside databases
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Publicationsfor S100G gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for S100G gene, integrated from 9 sources (see all 144 ): (articles sorted by number of sources associating them with S100G) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning and chromosomal assignment of human calbindin- D9k. (PubMed id 1610358) 1 , 2 , 3, 9 Howard A.... Walters J.R.I. (1992) Molecular cloning of the full-length cDNA encoding the human calbindin-D9k. (PubMed id 1379540) 1 , 2 , 3, 9 Jeung E.B....Leung P.C. (1992) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation. (PubMed id 8308886) 1 , 2 Jeung E.B.... Krisinger J. (1994) Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. (PubMed id 15217781) 1 , 9 Wang L....Fleet J.C. (2004) Calbindin-D9K gene expression in human myometrium during pregnancy and labor. (PubMed id 8045984) 1 , 9 Miller E.K....Iacopino A.M. (1994) Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues. (PubMed id 2009668) 1 , 9 Balmain N. (1991) Factors involved in the duodenal expression of the human calbindin-D9k gene. (PubMed id 10417310) 1 , 9 Barley N.F....Walters J.R. (1999) Identification of osteocalcin mRNA in nonosteoid tissue of rats and humans by reverse transcription-polymerase chain reaction. (PubMed id 7817802) 1 , 9 Fleet J.C. and Hock J.M. (1994)
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External Searches for S100G gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing S100G gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing S100G gene
(According to HUGE )
About This Section --
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Specialized Databases showing S100G gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for S100G gene: Search GeneIP for patents involving S100G GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor S100G gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for S100G OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for S100G OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for S100G OriGene Protein Over-expression Lysate for S100G Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for S100G Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for S100G OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for S100G Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for S100G OriGene Custom Protein Services for S100G OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat S100G QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing S100G QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100G QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat S100G QIAGEN QuantiFast Probe-based Assays in human , mouse , rat S100G QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat S100G
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S100G Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100G
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat S100G
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