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Aliases for S100G Gene

Aliases for S100G Gene

  • S100 Calcium Binding Protein G 2 3 5
  • Calbindin-D9K 2 3 4
  • Calbindin 3, (Vitamin D-Dependent Calcium-Binding Protein) 2 3
  • Vitamin D-Dependent Calcium-Binding Protein, Intestinal 3 4
  • CABP9K 3 4
  • CALB3 3 4
  • CABP 3 4
  • S100 Calcium-Binding Protein G 4
  • Protein S100-G 3
  • Calbindin D9K 3
  • CaBP1 3
  • S100D 4

External Ids for S100G Gene

Previous HGNC Symbols for S100G Gene

  • CALB3

Previous GeneCards Identifiers for S100G Gene

  • GC0XP016427
  • GC0XP016578
  • GC0XP014422

Summaries for S100G Gene

Entrez Gene Summary for S100G Gene

  • This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100G Gene

S100G (S100 Calcium Binding Protein G) is a Protein Coding gene. Among its related pathways are Mineral absorption. GO annotations related to this gene include calcium ion binding and vitamin D binding.

Gene Wiki entry for S100G Gene

Additional gene information for S100G Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100G Gene

Genomics for S100G Gene

Regulatory Elements for S100G Gene

Enhancers for S100G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH016603 1.2 Ensembl ENCODE 11.6 -45.4 -45403 2 ELF3 ZFP64 RFX5 TCF12 ZNF121 ZNF138 GATA2 ZNF354C RCOR1 ZNF202 TXLNG CTPS2 S100G GC0XP016584 MIR548AM
GH0XH016585 1 Ensembl ENCODE 11.1 -63.8 -63835 1 HINFP ETV1 CEBPG PYGO2 ZNF644 RELA IRF9 ZNF766 ZNF639 STAT1 S100G GC0XP016584 MIR548AM
GH0XH016628 0.6 ENCODE 12 -20.7 -20746 1 CTCF NR4A1 TAL1 ZNF592 TCF12 ZNF316 POLR2A HMBOX1 MYC S100G MIR548AM
GH0XH016612 0.4 ENCODE 11.6 -36.7 -36707 2 POU5F1 TCF7L2 S100G MIR548AM GC0XP016584
GH0XH016589 0.4 ENCODE 11.5 -60.6 -60608 0 FOS S100G GC0XP016584 MIR548AM
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S100G on UCSC Golden Path with GeneCards custom track

Genomic Location for S100G Gene

Chromosome:
X
Start:
16,650,158 bp from pter
End:
16,654,670 bp from pter
Size:
4,513 bases
Orientation:
Plus strand

Genomic View for S100G Gene

Genes around S100G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100G Gene

Proteins for S100G Gene

  • Protein details for S100G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29377-S100G_HUMAN
    Recommended name:
    Protein S100-G
    Protein Accession:
    P29377
    Secondary Accessions:
    • Q5JS49

    Protein attributes for S100G Gene

    Size:
    79 amino acids
    Molecular mass:
    9016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for S100G Gene

Post-translational modifications for S100G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100G Gene

Domains & Families for S100G Gene

Gene Families for S100G Gene

Suggested Antigen Peptide Sequences for S100G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29377

UniProtKB/Swiss-Prot:

S100G_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100G: view

Function for S100G Gene

Gene Ontology (GO) - Molecular Function for S100G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005499 vitamin D binding IEA --
GO:0005509 calcium ion binding IEA,TAS --
GO:0046872 metal ion binding IEA --
GO:0046914 transition metal ion binding IEA --
genes like me logo Genes that share ontologies with S100G: view
genes like me logo Genes that share phenotypes with S100G: view

Animal Models for S100G Gene

MGI Knock Outs for S100G:

Animal Model Products

CRISPR Products

miRNA for S100G Gene

miRTarBase miRNAs that target S100G

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for S100G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100G Gene

Localization for S100G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100G gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for S100G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with S100G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for S100G Gene

Pathways & Interactions for S100G Gene

SuperPathways for S100G Gene

SuperPathway Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with S100G: view

Pathways by source for S100G Gene

1 KEGG pathway for S100G Gene

Interacting Proteins for S100G Gene

Selected Interacting proteins: P29377-S100G_HUMAN for S100G Gene via IID

Gene Ontology (GO) - Biological Process for S100G Gene

None

No data available for SIGNOR curated interactions for S100G Gene

Drugs & Compounds for S100G Gene

(15) Drugs for S100G Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Citrate Approved Pharma Carrier, substrate 0
Calcium Phosphate Approved Pharma Carrier, substrate 0
N-Formylmethionine Experimental Pharma Target 0

(8) Additional Compounds for S100G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100G: view

Transcripts for S100G Gene

mRNA/cDNA for S100G Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for S100G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for S100G Gene

No ASD Table

Relevant External Links for S100G Gene

GeneLoc Exon Structure for
S100G
ECgene alternative splicing isoforms for
S100G

Expression for S100G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x43.8).

Protein differential expression in normal tissues from HIPED for S100G Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S100G Gene



Protein tissue co-expression partners for S100G Gene

NURSA nuclear receptor signaling pathways regulating expression of S100G Gene:

S100G

SOURCE GeneReport for Unigene cluster for S100G Gene:

Hs.639

Evidence on tissue expression from TISSUES for S100G Gene

  • Intestine(3.5)
genes like me logo Genes that share expression patterns with S100G: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100G Gene

Orthologs for S100G Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100G 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia S100G 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100G 33 34
  • 88.19 (n)
rat
(Rattus norvegicus)
Mammalia S100g 33
  • 80.17 (n)
oppossum
(Monodelphis domestica)
Mammalia S100G 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100g 33 16 34
  • 77.64 (n)
Species where no ortholog for S100G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100G Gene

ENSEMBL:
Gene Tree for S100G (if available)
TreeFam:
Gene Tree for S100G (if available)

Paralogs for S100G Gene

(16) SIMAP similar genes for S100G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100G: view

No data available for Paralogs for S100G Gene

Variants for S100G Gene

Sequence variations from dbSNP and Humsavar for S100G Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000238498 -- 16,649,358(+) AAACC(C/T)GCTTC intron-variant, upstream-variant-2KB
rs1000976761 -- 16,652,027(+) GGGGG(C/G)CAGTG intron-variant
rs1001006198 -- 16,652,431(+) TGACC(C/T)CAGAA intron-variant
rs1001292677 -- 16,651,514(+) TTAGC(C/T)GGCCT intron-variant
rs1001597101 -- 16,648,073(+) ACTCC(A/C)ACCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S100G Gene

Variant ID Type Subtype PubMed ID
nsv6816 CNV insertion 18451855

Variation tolerance for S100G Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100G Gene

Disorders for S100G Gene

Relevant External Links for S100G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100G

No disorders were found for S100G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100G Gene

Publications for S100G Gene

  1. Molecular cloning and chromosomal assignment of human calbindin-D9k. (PMID: 1610358) Howard A … Walters JR (Biochemical and biophysical research communications 1992) 2 3 4 22 60
  2. Molecular cloning of the full-length cDNA encoding the human calbindin-D9k. (PMID: 1379540) Jeung EB … Leung PC (FEBS letters 1992) 2 3 4 22 60
  3. [Effect of parathyroid hormone and 1,25-(OH)2-D3 on the expression of the mRNA of calbindin D9k in Caco-2 cells]. (PMID: 17712966) Mao X … Huo Z (Wei sheng yan jiu = Journal of hygiene research 2007) 3 22 60
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for S100G Gene

Sources for S100G Gene

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