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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100G Gene

protein-coding   GIFtS: 54
GCID: GC0XP016668

S100 calcium binding protein G

(Previous names: calbindin 3, (vitamin D-dependent calcium-binding protein)...)
(Previous symbol: CALB3)
 Explore 18 diseases affiliated with
S100G via our new
 Human Malady Compendium 
Biological research products
for S100G
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
S100 Calcium Binding Protein G1 2     S100 Calcium-Binding Protein G2 3
CABP9K1 2 3 5     Calbindin D9K2
CALB31 2 3 5     Calbindin-D9K1
CABP11 2     Protein S100-G2
Calbindin 3, (Vitamin D-Dependent Calcium-Binding Protein)1 2     Calbindin-D9k3
Vitamin D-Dependent Calcium-Binding Protein, Intestinal2 3     S100D3
CABP2 3     

External Ids:    HGNC: 14361   Entrez Gene: 7952   Ensembl: ENSG000001699067   OMIM: 3020205   UniProtKB: P293773   

Export aliases for S100G gene to outside databases

Previous GC identifers: GC0XP016427 GC0XP016578 GC0XP014422


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S100G:
This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a
family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the
intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The
protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in
duodenal basolateral membrane vesicles. (provided by RefSeq, Jul 2008)

Gene Wiki entry for S100G


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100G gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   c-Myb   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100G promoter sequence
   Search SABiosciences Chromatin IP Primers for S100G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

S100G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100G gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP016668:  view genomic region     (about GC identifiers)

Start:
16,668,281 bp from pter      End:
16,672,793 bp from pter
Size:
4,513 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S100G_HUMAN, P29377 (See protein sequence)
Recommended Name: Protein S100-G  
Size: 79 amino acids; 9016 Da
Secondary accessions: Q5JS49

Explore the universe of human proteins at neXtProt for S100G: NX_P29377

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29377

  • S100G Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004048.1  
    ENSEMBL proteins: 
     ENSP00000369547  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for S100G
    Uscn Proteins for S100G

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--


    S100G for ontologies           About GeneDecksing



    S100G Antibody Products: 
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    Uscn ELISAs and CLIAs for S100G


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    S100G for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018248 EF-hand
     IPR013787 S100_Ca-bd_sub

    Graphical View of Domain Structure for InterPro Entry P29377

    ProtoNet protein and cluster: P29377

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S100G_HUMAN, P29377
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat S100G
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    SwitchGear 3'UTR luciferase reporter plasmidS100G 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: S100G
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100G

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005499vitamin D binding IEA--
    GO:0005509calcium ion binding IEA--


    S100G for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for S100G:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out S100gtm1Ebje for S100G
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S100g):
     homeostasis/metabolism  normal 

    S100G for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mineral absorption
    Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for S100G):
        Mineral absorption


    S100G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S100G

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for S100G

    1 DrugBank Compound for S100G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    10/20 Novoseek chemical compound relationships for S100G gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,25 dihydroxy vitamin d3 69.4 8 1829088 (1), 7593254 (1), 8915780 (1), 9731705 (1) (see all 7)
    calcium 67.3 148 12810153 (4), 8389885 (4), 8395333 (4), 1539638 (3) (see all 68)
    vitamin d 65.2 19 2009668 (3), 2072223 (2), 9731705 (1), 11545681 (1) (see all 12)
    intron a 56.6 3 7711170 (2), 7598905 (1)
    calcitriol 54.5 9 7816252 (4), 10198340 (1), 12181175 (1)
    quin2 50.5 1 2193686 (1)
    p-mca 46.2 5 12181175 (2), 12597618 (2)
    amide 43.2 2 2166565 (1), 17536784 (1)
    gaba 15.9 10 15269970 (2), 8276998 (1), 15590911 (1), 15236231 (1)
    estrogen 15.7 10 8698870 (1), 7598905 (1), 19017814 (1), 7711170 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about S100G 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for S100G gene: 
    NM_004057.2  

    Unigene Cluster for S100G:

    S100 calcium binding protein G
    Hs.639
    Unigene Representative Sequence: L13220
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380200(uc004cxn.1)

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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S100G (see all 7)
    OriGene shRNA RFP: S100G
    OriGene siRNA: S100G
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100G

    Additional cDNA sequence: 

    BC112174.1 L13220.1 X65869.1 

    1 DOTS entry:

    DT.406357 

    3 AceView cDNA sequences:

    L13220 NM_004057 X65869 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    S100G expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See S100G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100G

    SOURCE GeneReport for Unigene cluster: Hs.639
        SABiosciences Expression via Pathway-Focused PCR Array including S100G: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for S100G gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100g1 , 5 S100 calcium binding protein G1, 5 77.64(n)1
    74.68(a)1
      X (75.15 cM)5
    123091  NM_009789.21  NP_033919.11 
     1629619925 


    ENSEMBL Gene Tree for S100G (if available)
    TreeFam Gene Tree for S100G (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/76 NCBI SNPs in S100G are shown (see all 76    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911024701,2
    --16666551(+) GCAGAC/GTGGTG 4 -- int1 us2k10--------
    rs734503031,2
    C,--16666651(+) ACAAAA/C/TGCCTA 4 -- int1 us2k12WA CSA 3
    rs625890741,2
    C,--16667073(+) ATTCTG/ATAAGT 4 -- us2k1 int11Minor allele frequency- A:0.00NA 2
    rs59803101,2
    C,F,A,H,--16667224(+) TCAATC/TTCCTT 4 -- int1 us2k1 tfbs325Minor allele frequency- N:0.00NS EA NA WA CSA 1818
    rs1828932741,2
    --16667245(+) AATCAC/TGGCAG 4 -- us2k1 int10--------
    rs1885543851,2
    --16667419(+) TTACTA/CAATAT 4 -- int1 us2k10--------
    rs732071131,2
    C,--16667468(+) CTTTCT/CACTTC 4 -- int1 us2k11Minor allele frequency- C:0.00NA 1
    rs1456490071,2
    --16667473(+) CACTTA/CTTAAA 4 -- int1 us2k10--------
    rs1481005561,2
    --16667761(+) AGGCAG/TGTACC 4 -- int1 us2k10--------
    rs1928906921,2
    --16667865(+) TGCCTC/TGGCCT 4 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for S100G (16668281 - 16672793 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for S100G: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100G
    DNA2.0 Custom Variant and Variant Library Synthesis for S100G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    S100G for disorders           About GeneDecksing

    OMIM gene information: 302020    OMIM disorders: --

    18 diseases for S100G:    About MalaCards
    duodenitis    duodenum cancer    spinocerebellar ataxia    osteomalacia
    parkinson's disease    rickets    down syndrome    neurologic diseases
    leiomyoma    choriocarcinoma    ataxia    dementia
    cerebritis    retinitis    thyroiditis    adenocarcinoma
    hepatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for S100G:
    Duodenum cancer     Rickets

    4 Novoseek disease relationships for S100G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy temporal lobe 10.6 1 1865007 (1)
    senile plaques 8.52 1 2142259 (1)
    tumors 1.07 2 8698870 (1), 11912242 (1)
    parkinson disease 0 3 11086288 (2), 8358501 (1)


    Export disorders for S100G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100G gene, integrated from 9 sources (see all 144):
    (articles sorted by number of sources associating them with S100G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal assignment of human calbindin- D9k. (PubMed id 1610358)1, 2, 3, 9 Howard A.... Walters J.R.I. (1992)
    2. Molecular cloning of the full-length cDNA encoding the human calbindin-D9k. (PubMed id 1379540)1, 2, 3, 9 Jeung E.B....Leung P.C. (1992)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation. (PubMed id 8308886)1, 2 Jeung E.B.... Krisinger J. (1994)
    6. Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. (PubMed id 15217781)1, 9 Wang L....Fleet J.C. (2004)
    7. Calbindin-D9K gene expression in human myometrium during pregnancy and labor. (PubMed id 8045984)1, 9 Miller E.K....Iacopino A.M. (1994)
    8. Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues. (PubMed id 2009668)1, 9 Balmain N. (1991)
    9. Factors involved in the duodenal expression of the human calbindin-D9k gene. (PubMed id 10417310)1, 9 Barley N.F....Walters J.R. (1999)
    10. Identification of osteocalcin mRNA in nonosteoid tissue of rats and humans by reverse transcription-polymerase chain reaction. (PubMed id 7817802)1, 9 Fleet J.C. and Hock J.M. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 795 HGNC: 1436 AceView: S100G Ensembl:ENSG00000169906 euGenes: HUgn795
    ECgene: S100G Kegg: 795 H-InvDB: S100G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for S100G gene:
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