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S100G Gene

protein-coding GIFtS: 50

GC0XP016578

S100 calcium binding protein G
(Previous names: calbindin 3, (vitamin D-dependent calcium-binding protein) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CALB3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CABP ^³
CABP1 ^¹, ²
CABP9K ^¹, ², ³
CALB3 ^², ³
Calbindin-D9k ^³
MGC138379 ^²
OTTHUMP00000022988 ^²
S100D ^³
calbindin-D9K ^²

Descriptions
S100 calcium binding protein G ^²
S100 calcium-binding protein G ^³
Vitamin D-dependent calcium-binding protein, intestinal ^³
calbindin 3 ^²
calbindin 3, (vitamin D-dependent calcium-binding protein) ^¹, ²
calbindin D9K ^²

External Ids
HGNC: 1436¹
Entrez Gene: 795²
UniProtKB: P29377³
Ensembl: ENSG00000169906⁷

Search outside databases for aliases for S100G gene

Previous GC identifer: GC0XP016427

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100G:

This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic

protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin,

troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its

expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by

buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral

membrane vesicles. [provided by RefSeq]

Gene Wiki entry for S100G

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the S100G gene

Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.2

S100G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP016578: (about GC identifiers)

Start:	16,578,202 bp from pter
End:	16,582,712 bp from pter
Size:	4,511 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S100G_HUMAN, P29377 (See protein sequence)

Recommended Name: Protein S100-G

Size: 79 amino acids; 9016 Da

Secondary accessions: Q5JS49

REFSEQ proteins: NP_004048.1

ENSEMBL proteins:

ENSP00000369547

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for S100G
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S100G, S100G + ATP7A)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016323	basolateral plasma membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--

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Antibodies for S100G:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for S100G
	R&D Systems Antibodies for S100G (Calbindin D)
	Antibodies from Abcam (S100G, S100G + ATP7A), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for S100G

Assays for S100G:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P29377

ProtoNet protein and cluster: P29377

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S100G_HUMAN, P29377

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100G)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100G)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004057

Applied Biosystems Silencer® siRNAs for S100G

Sigma-Aldrich siRNA and siRNA Panels for S100G

Sigma-Aldrich shRNA Panels and shRNA for S100G

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100G
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004057
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004057
untagged cDNA clone in CMV expression vector: NM_004057

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004057

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for S100g):

homeostasis/metabolism

normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005499	vitamin D binding	IEA	--
GO:0005509	calcium ion binding	TAS	1610358

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for S100G (Your Favorite Gene powered by Ingenuity)

VDR/RXR Activation

GeneDecks S100G for the pathways selected above

About GeneDecksing

5/12 Interacting proteins for S100G (ENSP00000369547³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR1	ENSP00000206249³	STRING (score=.966)
CALB1	ENSP00000265431³	STRING (score=.956)
HRAS	ENSP00000373382³	STRING (score=.917)
CSF1	ENSP00000349854³	STRING (score=.899)
FOS	ENSP00000306245³	STRING (score=.869)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for S100G:

Metabolite Mixed Agonist/Antagonist Antagonist Blocker Agonist Inhibitor

Ligand

Browse Tocris compounds for S100G
10/12 Novoseek chemical compound relationships for S100G gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1,25 dihydroxy vitamin d3	70.04	8	1829088 (1), 7593254 (1), 8915780 (1), 9731705 (1) (see all 7)
calcium	67.19	144	12810153 (4), 8389885 (4), 8395333 (4), 1539638 (3) (see all 66)
quin2	51.01	1	2193686 (1)
p-mca	47.70	5	12181175 (2), 12597618 (2)
amide	44.83	2	2166565 (1), 17536784 (1)
lysine	13.61	2	7832981 (1), 8683586 (1)
proline	10.89	1	2350544 (1)
cadmium	7.91	1	7666423 (1)
progesterone	0.38	2	11730918 (1), 7711170 (1)
estradiol	0.00	1	8698870 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100G)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100G)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004057

Sigma-Aldrich siRNA and siRNA Panels for S100G

Sigma-Aldrich shRNA Panels and shRNA for S100G

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004057

REFSEQ mRNAs for S100G gene:

NM_004057.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004057

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004057
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004057
                                 untagged cDNA clone in CMV expression vector: NM_004057

Additional cDNA sequence:

BC112174.1 L13220.1 X65869.1

1 DOTS entry:

DT.406357

3 AceView cDNA sequences:

X65869 NM_004057 L13220

highest scoring ESTs for S100G:

L13220 X65869 NM_004057 BC112174 BF839137

Unigene Cluster for S100G:

S100 calcium binding protein G

Hs.639

Unigene Representative Sequence: L13220

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000380200

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100G expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100G

¹ / ² / ³

3 probe-sets matching S100G gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34612_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L13220	1.00	1.00	1.00	1
207885_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004057	0.60	1.00	0.82	1
207885_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.639
Expression variation in blood from EXPOLDB for S100G

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100G gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S100G¹	--	S100 calcium binding protein G	88.19(n) 92.41(a)	607826 XM_843973.1 XP_849066.1
chimpanzee (Pan troglodytes)	S100G¹	--	S100 calcium binding protein G	100(n) 100(a)	737870 XM_001139782.1 XP_001139782.1
cow (Bos taurus)	S100G¹	--	S100 calcium binding protein G	86.92(n) 88.61(a)	281658 NM_174257.2 NP_776682.1
rat (Rattus norvegicus)	S100g¹	--	S100 calcium binding protein G	80.17(n) 78.48(a)	24249 NM_012521.1 NP_036653.1
mouse (Mus musculus)	S100g^{1, 5}	X⁵	S100 calcium binding protein G^{1, 5}	77.64(n)¹ 74.68(a)¹	12309¹ NM_009789.2¹ NP_033919.1¹ AF028071⁵ AF136283⁵ (see all 18)

About this table Species with no ortholog for S100G

ENSEMBL Gene Tree for S100G

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 302020

4 Novoseek disease relationships for S100G gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsy temporal lobe	12.25	1	1865007 (1)
senile plaques	10.15	1	2142259 (1)
tumors	1.06	2	8698870 (1), 11912242 (1)
parkinson disease	0.00	3	11086288 (2), 8358501 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/137 PubMed articles for S100G gene (see all 137 ):

Molecular cloning and chromosomal assignment of human calbindin- D9k. (PubMed id 1610358)^{1, 2, 3, 4} Howard A.... Walters J.R.I. (1992)
Molecular cloning of the full-length cDNA encoding the human calbindin-D9k. (PubMed id 1379540)^{1, 2, 3, 4} Jeung E.B....Leung P.C. (1992)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation. (PubMed id 8308886)^{3, 4} Jeung E.B.... Krisinger J. (1994)
Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. (PubMed id 15217781)^{1, 3} Wang L....Fleet J.C. (2004)
Calbindin-D9K gene expression in human myometrium during pregnancy and labor. (PubMed id 8045984)^{1, 3} Miller E.K....Iacopino A.M. (1994)
Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues. (PubMed id 2009668)^{1, 3} Balmain N. (1991)
Factors involved in the duodenal expression of the human calbindin-D9k gene. (PubMed id 10417310)^{1, 3} Barley N.F....Walters J.R. (1999)
Identification of osteocalcin mRNA in nonosteoid tissue of rats and humans by reverse transcription-polymerase chain reaction. (PubMed id 7817802)^{1, 3} Fleet J.C. and Hock J.M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 795	HGNC: 1436	AceView: S100G	Ensembl:ENSG00000169906	euGenes: HUgn795
ECgene: S100G	H-InvDB: S100G

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for S100G	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for S100G
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S100G:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100G-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100G		Antibodies for S100G
	Explore super-pooled esiRNAs		Proteins for S100G
	Lentivirus-delivered shRNAs for S100G		Small molecules for S100G
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (S100G, S100G + ATP7A)

Search OriGene for S100G

Search Tocris compounds for S100G

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for S100G

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S100G Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for S100G

Summaries
for S100G

Genomic Location
for S100G

Proteins
for S100G

Protein Domains/
Families
for S100G

Gene Function
for S100G

Pathways & Interactions
for S100G

Drugs & Compounds
for S100G

Transcripts
for S100G

Expression
for S100G

Orthologs
for S100G

Paralogs
for S100G

SNPs/Variants
for S100G

Disorders & Mutations
for S100G

Medical News
for S100G

Publications
for S100G

Search for S100G

Genome Databases showing S100G

Other Databases showing S100G

Specialized Databases showing S100G

Licensable Technologies
for S100G

Services
for S100G

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100G Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor S100G

Summariesfor S100G

Genomic Locationfor S100G

Proteinsfor S100G

Protein Domains/Familiesfor S100G

Gene Functionfor S100G

Pathways & Interactionsfor S100G

Drugs & Compoundsfor S100G

Transcriptsfor S100G

Expression for S100G

Orthologsfor S100G

Paralogsfor S100G

SNPs/Variantsfor S100G

Disorders & Mutationsfor S100G

Medical Newsfor S100G

Publicationsfor S100G

Search for S100G

Genome Databases showing S100G

Other Databases showing S100G

Specialized Databases showing S100G

Licensable Technologiesfor S100G

Servicesfor S100G

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100G

Summaries
for S100G

Genomic Location
for S100G

Proteins
for S100G

Protein Domains/
Families
for S100G

Gene Function
for S100G

Pathways & Interactions
for S100G

Drugs & Compounds
for S100G

Transcripts
for S100G

Expression
for S100G

Orthologs
for S100G

Paralogs
for S100G

SNPs/Variants
for S100G

Disorders & Mutations
for S100G

Medical News
for S100G

Publications
for S100G

Licensable Technologies
for S100G

Services
for S100G