Free for academic non-profit institutions. Other users need a Commercial license

Aliases for S100B Gene

Aliases for S100B Gene

  • S100 Calcium Binding Protein B 2 3
  • S-100 Protein Subunit Beta 3 4
  • S100 Calcium Binding Protein, Beta (Neural) 2
  • S100 Calcium-Binding Protein, Beta (Neural) 3
  • S-100 Calcium-Binding Protein, Beta Chain 3
  • S100 Calcium-Binding Protein B 4
  • S-100 Protein Beta Chain 4
  • Protein S100-B 3
  • S100beta 3
  • S100-B 3
  • S100 3
  • NEF 3

External Ids for S100B Gene

Previous GeneCards Identifiers for S100B Gene

  • GC21M044525
  • GC21M046875
  • GC21M046874
  • GC21M046842
  • GC21M048018
  • GC21M033398

Summaries for S100B Gene

Entrez Gene Summary for S100B Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100B Gene

S100B (S100 Calcium Binding Protein B) is a Protein Coding gene. Diseases associated with S100B include granular cell tumor and ossifying fibromyxoid tumor. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100B Gene

  • Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Tocris Summary for S100B Gene

Gene Wiki entry for S100B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100B Gene

Genomics for S100B Gene

Genomic Location for S100B Gene

Start:
46,598,618 bp from pter
End:
46,605,208 bp from pter
Size:
6,591 bases
Orientation:
Minus strand

Genomic View for S100B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100B Gene

Proteins for S100B Gene

  • Protein details for S100B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04271-S100B_HUMAN
    Recommended name:
    Protein S100-B
    Protein Accession:
    P04271
    Secondary Accessions:
    • D3DSN6

    Protein attributes for S100B Gene

    Size:
    92 amino acids
    Molecular mass:
    10713 Da
    Quaternary structure:
    • Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with CACYBP in a calcium-dependent manner. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    Miscellaneous:
    • In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue

    Three dimensional structures from OCA and Proteopedia for S100B Gene

neXtProt entry for S100B Gene

Proteomics data for S100B Gene at MOPED

Post-translational modifications for S100B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for S100B (S100B)

Protein Products

No data available for DME Specific Peptides for S100B Gene

Domains for S100B Gene

Gene Families for S100B Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

Suggested Antigen Peptide Sequences for S100B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04271

UniProtKB/Swiss-Prot:

S100B_HUMAN :
  • P04271
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100B: view

Function for S100B Gene

Molecular function for S100B Gene

GENATLAS Biochemistry: S100 calcium binding protein,beta polypeptide,neuronal,probably including locus control region LCR-S100B,stimulating GUCY2D at micromolar concentration of Ca2+ for retinal specific activity
UniProtKB/Swiss-Prot Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Gene Ontology (GO) - Molecular Function for S100B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005509 calcium ion binding NAS 9519411
GO:0005515 protein binding IPI 10913138
GO:0008270 zinc ion binding ISS --
GO:0042802 identical protein binding IPI 10913138
genes like me logo Genes that share ontologies with S100B: view

Phenotypes for S100B Gene

genes like me logo Genes that share phenotypes with S100B: view

Animal Models for S100B Gene

MGI Knock Outs for S100B:

miRNA for S100B Gene

miRTarBase miRNAs that target S100B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S100B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for S100B Gene

Localization for S100B Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100B Gene COMPARTMENTS Subcellular localization image for S100B gene
Compartment Confidence
nucleus 5
extracellular 4
cytoskeleton 3
cytosol 3
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for S100B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 10913138
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with S100B: view

Pathways for S100B Gene

genes like me logo Genes that share pathways with S100B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for S100B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis TAS 8202493
GO:0007417 central nervous system development TAS 8202493
GO:0007611 learning or memory ISS --
GO:0007613 memory IEA --
GO:0008283 cell proliferation TAS 8202493
genes like me logo Genes that share ontologies with S100B: view

Compounds for S100B Gene

(5) Tocris Compounds for S100B Gene

Compound Action Cas Number
MOG (35-55) Encephalitogenic myelin oligodendrocyte glycoprotein fragment [149635-73-4]
Myelin Basic Protein (87-99) Major antigenic component implicated in the pathophysiology of multiple sclerosis [118506-26-6]
Nogo-66 (1-40) Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration [475221-20-6]
ONO 2506 Inhibits S100B synthesis; neuroprotective [185517-21-9]
PLP (139-151) Encephalitogenic myelin proteolipid fragment [122018-58-0]

(1) HMDB Compounds for S100B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) Drugbank Compounds for S100B Gene

(96) Novoseek inferred chemical compound relationships for S100B Gene

Compound -log(P) Hits PubMed IDs
s 100 64 21
mucicarmine 62.6 3
reticulin 57 5
hematoxylin 56.9 18
paraffin 52.7 17
genes like me logo Genes that share compounds with S100B: view

Transcripts for S100B Gene

mRNA/cDNA for S100B Gene

Unigene Clusters for S100B Gene

S100 calcium binding protein B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S100B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for S100B Gene

GeneLoc Exon Structure for
S100B
ECgene alternative splicing isoforms for
S100B

Expression for S100B Gene

mRNA expression in normal human tissues for S100B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (17.0) and Brain - Substantia nigra (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for S100B Gene

SOURCE GeneReport for Unigene cluster for S100B Gene Hs.422181

mRNA Expression by UniProt/SwissProt for S100B Gene

P04271-S100B_HUMAN
Tissue specificity: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues
genes like me logo Genes that share expressions with S100B: view

In Situ Assay Products

Orthologs for S100B Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100B 35
  • 98.91 (n)
  • 100 (a)
S100B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100B 35
  • 90.22 (n)
  • 96.74 (a)
S100B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100B 35
  • 78.62 (n)
  • 78.26 (a)
S100B 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100b 35
  • 85.51 (n)
  • 98.91 (a)
S100b 16
S100b 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100B 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100b 35
  • 85.87 (n)
  • 97.83 (a)
chicken
(Gallus gallus)
Aves S100B 35
  • 83.33 (n)
  • 84.78 (a)
S100B 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii s100b 35
  • 67.4 (n)
  • 61.54 (a)
s100b 36
  • 59 (a)
OneToOne
wufq18b10 35
Species with no ortholog for S100B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100B Gene

ENSEMBL:
Gene Tree for S100B (if available)
TreeFam:
Gene Tree for S100B (if available)

Paralogs for S100B Gene

Selected SIMAP similar genes for S100B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with S100B: view

Variants for S100B Gene

Sequence variations from dbSNP and Humsavar for S100B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs9722 -- 46,599,326(-) AGAGA(C/T)GGTCA utr-variant-3-prime
rs881827 -- 46,599,955(-) GGCCA(C/T)GTTCC intron-variant
rs1051169 -- 46,602,317(-) GAACT(C/G/T)AAGGA synonymous-codon, reference
rs2154586 -- 46,603,603(+) CTTGA(A/G)TTCTA intron-variant
rs2186358 -- 46,602,462(+) TCATC(A/C)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100B Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv914148 CNV Loss 21882294
nsv528947 CNV Gain 19592680
dgv1375e1 CNV Complex 17122850
esv34393 CNV Gain 17911159
nsv527542 CNV Loss 19592680
nsv528495 CNV Loss 19592680

Relevant External Links for S100B Gene

HapMap Linkage Disequilibrium report
S100B
Human Gene Mutation Database (HGMD)
S100B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100B Gene

Disorders for S100B Gene

(96) Novoseek inferred disease relationships for S100B Gene

Disease -log(P) Hits PubMed IDs
myoepithelioma 81.9 5
melanoma 80 259
tumors 77.2 152
granular cell tumor 76.2 8
perineurioma 75.2 3

Relevant External Links for S100B

Genetic Association Database (GAD)
S100B
Human Genome Epidemiology (HuGE) Navigator
S100B
genes like me logo Genes that share disorders with S100B: view

No data available for UniProtKB/Swiss-Prot for S100B Gene

Publications for S100B Gene

  1. Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. (PMID: 9925766) Yang Q. … Marks A. (Exp. Cell Res. 1999) 3 4 23
  2. The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. (PMID: 20351179) Gilquin B. … Baudier J. (Mol. Cell. Biol. 2010) 3 4 23
  3. Cloning and expression of the human S100 beta gene. (PMID: 2394738) Allore R.J. … Marks A. (J. Biol. Chem. 1990) 2 3 4
  4. The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. (PMID: 17624933) Friel L.A. … Espinoza J. (J Perinat Med 2007) 3 23 25
  5. Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells. (PMID: 19939849) Tskitishvili E. … Shimoya K. (Mol. Hum. Reprod. 2010) 3 23

Products for S100B Gene

  • Addgene plasmids for S100B

Sources for S100B Gene

Back to Top

Content