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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100B Gene

protein-coding   GIFtS: 71
GCID: GC21M048018

S100 Calcium Binding Protein B

(Previous names: S100 calcium binding protein, beta (neural))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
S100 Calcium Binding Protein B1 2     S100-B2
S-100 Calcium-Binding Protein, Beta Chain2 11     S100beta2
S-100 Protein Subunit Beta2 3     Protein S100-B2
S100 Calcium Binding Protein, Beta (Neural)1     S100 Calcium-Binding Protein, Beta (Neural)2
NEF2     S-100 Protein Beta Chain3
S1002     S100 Calcium-Binding Protein B3

External Ids:    HGNC: 105001   Entrez Gene: 62852   Ensembl: ENSG000001603077   OMIM: 1769905   UniProtKB: P042713   

Export aliases for S100B gene to outside databases

Previous GC identifers: GC21M044525 GC21M046875 GC21M046874 GC21M046842 GC21M033398


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S100B Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at
21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+
fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of
microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in
several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome,
epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100B Gene: 
S100B (S100 calcium binding protein B) is a protein-coding gene. Diseases associated with S100B include malignant peripheral nerve sheath tumor, and granular cell tumor, and among its related super-pathways are Immune System and PIP3 activates AKT signaling. GO annotations related to this gene include identical protein binding and calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S100B_HUMAN, P04271
Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist
for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both
divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation
of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after
myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By
similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial
localization

Gene Wiki entry for S100B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100B gene promoter:
         STAT1   AP-1   AP-2alpha isoform 3   AP-2alpha isoform 2   PPAR-gamma1   AP-2alpha isoform 4   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100B promoter sequence

   Search SABiosciences Chromatin IP Primers for S100B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
S100B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100B gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M048018:   GeneLoc Nature:405,311-319
Start:
48,018,531 bp from pter       33,524,582 bp from centromere
End:
48,025,121 bp from pter 33,525,899 bp from centromere
Size:
6,591 bases 1,318 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: M59488
genomic clones: PP9H11


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S100B_HUMAN, P04271 (See protein sequence)
Recommended Name: Protein S100-B  
Size: 92 amino acids; 10713 Da
Subunit: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer
binds two molecules of STK38 (By similarity). Interacts with CACYBP in a calcium-dependent manner (By
similarity). Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial
targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: In addition to metal-ion binding, this protein is involved with the regulation of protein
phosphorylation in brain tissue
6/8 PDB 3D structures from and Proteopedia for S100B (see all 8):
1MQ1 (3D)        1UWO (3D)        2H61 (3D)        2PRU (3D)        3CZT (3D)        3D0Y (3D)    
Secondary accessions: D3DSN6

Explore the universe of human proteins at neXtProt for S100B: NX_P04271

Explore proteomics data for S100B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04271

  • S100B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    S100B Protein Expression
    REFSEQ proteins: NP_006263.1  
    ENSEMBL proteins: 
     ENSP00000291700   ENSP00000356038   ENSP00000380769  
    Reactome Protein details: P04271
    Human Recombinant Protein Products for S100B: 
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    Sino Biological Recombinant Protein for S100B
    Sino Biological Cell Lysate for S100B 
    ProSpec Recombinant Protein for S100B
    Cloud-Clone Corp. Proteins for S100B 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA10913138
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IDA10913138
    GO:0005737cytoplasm ISS--

    S100B for ontologies           About GeneDecksing



    S100B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    5 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry P04271

    ProtoNet protein and cluster: P04271

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S100B_HUMAN, P04271
    Similarity: Belongs to the S-101 family
    Similarity: Contains 2 EF-hand domains


    S100B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S100B_HUMAN, P04271
    Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist
    for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both
    divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation
    of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after
    myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By
    similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial
    localization

         Genatlas biochemistry entry for S100B:
    S100 calcium binding protein,beta polypeptide,neuronal,probably including locus control region
    LCR-S100B,stimulating GUCY2D at micromolar concentration of Ca2+ for retinal specific activity

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005509calcium ion binding NAS9519411
    GO:0005515protein binding IPI10913138
    GO:0008270zinc ion binding ISS--
    GO:0042802identical protein binding IPI10913138
         
    S100B for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S100b):
     behavior/neurological  integument  normal 

    S100B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for S100B: S100btm1Ito S100btm1Daoh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for S100B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for S100B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for S100B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S100B 

    miRNA
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    miRTarBase miRNAs that target S100B:
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate S100B:
    hsa-miR-330-3p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-551b* hsa-miR-583
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for S100B About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    2PIP3 activates AKT signaling
    Signaling by ERBB40.67
    3Signaling by GPCR
    Signal Transduction0.55
    4Prolactin receptor signaling
    Nuclear signaling by ERBB40.38
    5Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for S100B
        Ca, cAMP and Lipid Signaling
    Neuroscience


    5/6        Reactome Pathways for S100B (see all 6)
        Advanced glycosylation endproduct receptor signaling
    Signal Transduction
    Signaling by ERBB4
    Immune System
    Innate Immune System



    S100B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for S100B (P042711, 2, 3 ENSP000002917004) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGERQ151092, 3, ENSP000003642174MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 STRING: ENSP00000364217
    ENSG00000206320Q151092, 3MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 
    ENSG00000229058Q151092, 3MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 
    ENSG00000230514Q151092, 3MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 
    ENSG00000231268Q151092, 3MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis TAS8202493
    GO:0007417central nervous system development TAS8202493
    GO:0007611learning or memory ISS--
    GO:0007613memory IEA--
    GO:0008283cell proliferation TAS8202493

    S100B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for S100B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PLP (139-151)Encephalitogenic myelin proteolipid fragment[122018-58-0]
    ONO 2506Inhibits S100B synthesis; neuroprotective[185517-21-9]
    C3bot (154-182)Neurotrophic fragment of clostridial C3 protein[1246280-79-4]
    MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
    Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

    1 HMDB Compound for S100B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 DrugBank Compounds for S100B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Calcium-- --target--17624933 17612632 17536784 17515952
    (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide-- --target--10592235
    2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide-- --target--10592235
    N-Formylmethionine-- --target--10592235
    Olopatadine-- 113806-05-6targetother/unknown11944917

    10/96 Novoseek inferred chemical compound relationships for S100B gene (see all 96)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s 100 64 35 9870671 (6), 8878020 (5), 11169510 (2), 16338157 (2) (see all 9)
    mucicarmine 62.6 3 11858401 (1), 15239680 (1), 10199475 (1)
    reticulin 57 5 1653908 (1), 11858401 (1), 2354404 (1), 15597767 (1) (see all 5)
    hematoxylin 56.9 19 15725798 (3), 7512798 (1), 16949932 (1), 19094127 (1) (see all 16)
    paraffin 52.7 19 7524376 (1), 7668412 (1), 10199466 (1), 8050903 (1) (see all 17)
    b 723 34.8 6 9808124 (1), 12481020 (1), 1693028 (1), 7678320 (1) (see all 6)
    orcein 29.3 1 16796160 (1)
    glycogen 24.3 3 8214396 (1), 8088719 (1), 15547779 (1)
    calcium 24.1 187 8688416 (6), 9428666 (4), 8805590 (3), 15882069 (3) (see all 99)
    tyrosine 19.1 56 18073204 (4), 15681409 (4), 9705913 (3), 9218412 (2) (see all 33)

    Search CenterWatch for drugs/clinical trials and news about S100B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for S100B gene: 
    NM_006272.2  

    Unigene Cluster for S100B:

    S100 calcium binding protein B
    Hs.422181  [show with all ESTs]
    Unigene Representative Sequence: BC041935
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291700(uc002zju.1) ENST00000367071(uc002zjv.1) ENST00000397648

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    BC001766.1 BC041935.1 CR542123.1 

    12 DOTS entries:

    DT.215194  DT.100758003  DT.95157592  DT.121136780  DT.121136796  DT.95120732  DT.100758001  DT.95157596 
    DT.100758004  DT.100758005  DT.121136789  DT.95157594 

    24/265 AceView cDNA sequences (see all 265):

    AA808065 BU731627 AW206771 BE465410 AI391682 BI494752 AW206399 BI756271 
    BI491621 AA831469 BI856702 BM694813 CB054226 CR542123 BE856467 AW137786 
    AA363992 AI339135 BM695249 BI496877 AW949406 W57800 BE275884 CD300759 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for S100B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                                -     -                                             
    SP2:                                -                                                   
    SP3:                                -     -           -                                 
    SP4:                          -     -     -           -                                 
    SP5:                                -                 -                                 


    ECgene alternative splicing isoforms for S100B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100B expression in normal human tissues (normalized intensities)      S100B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTGTAGA
    S100B Expression
    About this image


    S100B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             GABA neuron-like cells ( Generation of motor and gamma-aminobutyric acid (GABA)...
             Trigeminal Ganglion   
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
             sensory organ/ear/inner ear   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 6 entries
             Non-myelinating Schwann Cells Peripheral Nerve Domain
             Schwann cells
             autonomic/parasympathetic   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             skeleton/cranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             limb/hindlimb   

    See S100B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100B

    SOURCE GeneReport for Unigene cluster: Hs.422181

    UniProtKB/Swiss-Prot: S100B_HUMAN, P04271
    Tissue specificity: Although predominant among the water-soluble brain proteins, S100 is also found in a variety
    of other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including S100B: 
              Parkinson's Disease in human mouse rat
              Neurogenesis in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for S100B gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100b1 , 5 S100 protein, beta polypeptide, neural1, 5 85.51(n)1
    98.91(a)1
      10 (38.76 cM)5
    202031  NM_009115.31  NP_033141.11 
     762538535 
    chicken
    (Gallus gallus)
    Aves S100B1 S100 calcium binding protein B 83.33(n)
    84.78(a)
      424038  XM_001233034.2  XP_001233035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufq18b102 wufq18b10 73.83(n)   336344  BI427905.1 


    ENSEMBL Gene Tree for S100B (if available)
    TreeFam Gene Tree for S100B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S100B gene
    S100A112  S100A62  S100A12  S100A122  S100A42  S100A32  S100A102  S100Z2  
    S100P2  S100A22  S100A52  S100A92  
    18/22 SIMAP similar genes for S100B using alignment to 2 protein entries:     S100B_HUMAN (see all proteins) (see all similar genes):
    S100A1    S100A5    S100A6    S100A16    S100Z    S100A4
    S100A12    HRNR    S100A9    S100P    S100A11    RPTN
    S100A8    S100A2    S100A3    FLG2    S100A10    S100A13

    S100B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 SNPs in S100B are shown (see all 203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169235171,2
    C,F--48018073(+) GGCACG/CTGACT 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1503093821,2
    --48018089(+) GGACCA/GTTGGC 1 -- ds50010--------
    rs1824464531,2
    --48018104(+) CCCCTC/TCCTGG 1 -- ds50010--------
    rs99815821,2
    C,F--48018207(+) GCAGAA/CGGGAA 1 -- ds50015Minor allele frequency- C:0.18WA CSA NA 244
    rs99805841,2
    C,F,H--48018216(+) AAGCCG/ACGTTT 1 -- ds50016Minor allele frequency- A:0.21NS WA CSA 338
    rs1143420941,2
    C,F--48018247(+) ATGGCG/ACTGGA 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1130686531,2
    C,F--48018412(+) CACGCG/ACCACC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1490678131,2
    --48018425(+) GCCAGA/GCTACT 1 -- ds50010--------
    rs622257201,2
    F--48018492(+) TCCTGG/ACCTTG 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs99836981,2
    C,F,H--48018543(+) TTGAAC/TGCAGG 1 -- ut31 ese322Minor allele frequency- T:0.13NS EA NA WA CSA 1774

    HapMap Linkage Disequilibrium report for S100B (48018531 - 48025121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for S100B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528495CNV Loss19592680
    nsv914148CNV Loss21882294
    nsv527542CNV Loss19592680
    esv34393CNV Gain17911159
    nsv470910CNV Gain18288195
    nsv528947CNV Gain19592680
    dgv1375e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): S100B
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for S100B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176990    OMIM disorders: --

    20/249 diseases for S100B (see all 249):    About MalaCards
    malignant peripheral nerve sheath tumor    granular cell tumor    chordoid glioma    ossifying fibromyxoid tumor
    cellular schwannoma    meningeal melanocytoma    congenital granular cell tumor    epithelioid malignant peripheral nerve sheath tumor
    subependymal glioma    pituicytoma    ganglioglioma    congenital epulis
    superficial spreading melanoma    epulis    gliofibroma    odontogenic myxoma
    intraneural perineurioma    anaplastic ependymoma    gemistocytic astrocytoma    neurofibroma

    6 diseases from the University of Copenhagen DISEASES database for S100B:
    Cerebrovascular accident     Melanoma     Down syndrome     Schizophrenia
    Alzheimer's disease     Labyrinthine dysfunction

    S100B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for S100B gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myoepithelioma 81.9 5 1694334 (1), 8380682 (1), 1718079 (1), 8986967 (1) (see all 5)
    melanoma 80 442 8791271 (5), 15234232 (5), 10570381 (5), 19104452 (5) (see all 99)
    tumors 77.2 652 12759535 (4), 18454690 (4), 1380226 (4), 8986967 (4) (see all 99)
    granular cell tumor 76.2 9 7817938 (1), 8878020 (1), 12579997 (1), 15590438 (1) (see all 8)
    perineurioma 75.2 3 9221216 (1), 12459629 (1), 18434767 (1)
    mpnst 75.2 14 14508395 (3), 11580072 (1), 10584703 (1), 17910355 (1) (see all 9)
    malignant peripheral nerve sheath tumors 74.8 8 11145248 (1), 11732802 (1), 17119986 (1), 18480004 (1) (see all 7)
    schwannoma 73.6 32 15487453 (2), 18480004 (2), 1710946 (2), 1708642 (2) (see all 22)
    sarcoma clear cell 73.3 3 14666625 (1), 11211309 (1), 2004337 (1)
    immunodeficiency 72.1 241 9811718 (3), 1571013 (2), 12370346 (2), 9153233 (2) (see all 99)

    Genetic Association Database (GAD): S100B
    Human Genome Epidemiology (HuGE) Navigator: S100B (10 documents)

    Export disorders for S100B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100B gene, integrated from 9 sources (see all 1795):
    (articles sorted by number of sources associating them with S100B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human S100 beta gene. (PubMed id 2394738)1, 2, 3 Allore R.J.... Marks A. (1990)
    2. Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. (PubMed id 9925766)1, 2, 9 Yang Q.... Marks A. (1999)
    3. The calcium-dependent interaction between S100B and t he mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplas mic processing of ATAD3A. (PubMed id 20351179)1, 2, 9 Gilquin B....Baudier J. (2010)
    4. The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. (PubMed id 17624933)1, 7, 9 Friel L.A....Espinoza J. (2007)
    5. The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candi date genes. (PubMed id 22286170)1, 4 Cusanovich D.A....Gilad Y. (2012)
    6. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    7. Association study of astrocyte-derived protein S100B gene polymorphisms with major depressive disorder in Chinese people. (PubMed id 19497163)1, 4 Yang K....Su L.Y. (2009)
    8. Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals. (PubMed id 19330775)1, 4 Hohoff C....Rothermundt M. (2009)
    9. No Association of the rs9722 C >T in the S100B Gene and Susceptibility to Major Depression in a Chinese Population. (PubMed id 18939940)1, 4 Yang K....Su L.Y. (2008)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6285 HGNC: 10500 AceView: S100B Ensembl:ENSG00000160307 euGenes: HUgn6285
    ECgene: S100B H-InvDB: S100B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for S100B gene:
    Search GeneIP for patents involving S100B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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