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S100B Gene

protein-coding GIFtS: 69

GC21M046842

S100 calcium binding protein B
(Previous names: S100 calcium binding protein, beta (neural) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
NEF ^²
OTTHUMP00000174958 ^²
S100 ^²
S100beta ^¹, ²

Descriptions
S-100 calcium-binding protein, beta chain ^², 9
S-100 protein beta chain ^³
S-100 protein subunit beta ^³
S100 beta ^²
S100 calcium binding protein B ^²
S100 calcium binding protein, beta (neural) ^¹, ²
S100 calcium-binding protein B ^³
S100 calcium-binding protein, beta ^²
S100 calcium-binding protein, beta (neural) ^²

External Ids
HGNC: 10500¹
Entrez Gene: 6285²
UniProtKB: P04271³
Ensembl: ENSG00000160307⁷

Search outside databases for aliases for S100B gene

Previous GC identifers: GC21M044525 GC21M046875 GC21M046874

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100B:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand

calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide

range of cells, and involved in the regulation of a number of cellular processes such as cell

cycle progression and differentiation. S100 genes include at least 13 members which are located as

a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function

in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of

PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule

assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in

several neurological, neoplastic, and other types of diseases, including Alzheimer's disease,

Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

[provided by RefSeq]

UniProtKB/Swiss-Prot: S100B_HUMAN, P04271

Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different

affinities exist for both ions on each monomer. Physiological concentrations of potassium ion

antagonize the binding of both divalent cations, especially affecting high-affinity

calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory

intramolecular interactions within the kinase

Gene Wiki entry for S100B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

S100B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M046842:	GeneLoc	Nature:405,311-319
Start:	46,842,959 bp from pter	33,524,582 bp from centromere
End:	46,849,549 bp from pter	33,525,899 bp from centromere
Size:	6,591 bases	1,318 bases
Orientation:	minus strand	minus strand

RefSeq DNA sequence:

NC_000021.7 NT_011515.11

Whole chromosome sequencing:
cDNA sequence:	M59488
genomic clones:	PP9H11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S100B_HUMAN, P04271 (See protein sequence)

Recommended Name: Protein S100-B

Size: 92 amino acids; 10713 Da

Subunit: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The

S100B dimer binds two molecules of STK38 (By similarity). The S100B dimer interacts with two

molecules of CAPZA1

Subcellular location: Cytoplasm. Nucleus

Miscellaneous: In addition to metal-ion binding, this protein is involved with the regulation of

protein phosphorylation in brain tissue

PDB structures from and Proteopedia :

1MQ1 (3D)

1UWO (3D)

2H61 (3D)

2PRU (3D)

3CZT (3D)

3D0Y (3D)

3D10 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006263.1

ENSEMBL proteins:

ENSP00000380769 ENSP00000291700 ENSP00000356038

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S100 beta, S100)
	Human Recombinant Proteins from Abnova (S100B)

OriGene Purified Recombinant Human Protein: S100B

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	10913138
GO:0005634	nucleus	IDA	10913138
GO:0005737	cytoplasm	ISS	--

About this table

Antibodies for S100B:

	Invitrogen Antibodies for S100B
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for S100B
	R&D Systems Antibodies for S100B
	Antibodies from Abcam (S100 beta, S100), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S100B)
	Novus Biologicals Antibody for S100B

Assays for S100B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04271

ProtoNet protein and cluster: P04271

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S100B_HUMAN, P04271

Similarity: Belongs to the S-101 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006272

Applied Biosystems Silencer® siRNAs for S100B

Sigma-Aldrich siRNA and siRNA Panels for S100B

Sigma-Aldrich shRNA for S100B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006272
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006272
untagged cDNA clone in CMV expression vector: NM_006272

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006272

UniProtKB/Swiss-Prot: S100B_HUMAN, P04271

Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different

affinities exist for both ions on each monomer. Physiological concentrations of potassium ion

antagonize the binding of both divalent cations, especially affecting high-affinity

calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory

intramolecular interactions within the kinase

Genatlas biochemistry entry for S100B:

S100 calcium binding protein,beta polypeptide,neuronal,probably including locus control region

LCR-S100B,stimulating GUCY2D at micromolar concentration of Ca2+ for retinal specific activity

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for S100b):

behavior/neurological

nervous system

normal

touch/vibrissae

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	9519411
GO:0008270	zinc ion binding	ISS	--
GO:0042803	protein homodimerization activity	IPI	9519411
GO:0048154	S100 beta binding	IPI	9519411 10913138
GO:0048156	tau protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for S100B

5/77 Interacting proteins for S100B (P04271^{1, 2} ENSP00000291700³) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGER	Q15109², ENSP00000364211³	MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 STRING (score=.873)
S100A1	P23297¹, ENSP00000357687³	EBI-458391, EBI-743686 STRING (score=.953)
S100A6	P06703¹, ENSP00000357709³	EBI-458391, EBI-352877 STRING (score=.886)
S100A11	P31949¹	EBI-458391, EBI-701862
S100B	P04271¹	EBI-458391, EBI-458391

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007409	axonogenesis	TAS	8202493
GO:0007417	central nervous system development	TAS	8202493
GO:0007611	learning or memory	ISS	--
GO:0008283	cell proliferation	TAS	8202493

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100B
10/53 Novoseek chemical compound relationships for S100B gene (see all 53 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
s 100	64.91	35	9870671 (6), 8878020 (5), 11169510 (2), 16338157 (2) (see all 9)
mucicarmine	59.93	3	11858401 (1), 15239680 (1), 10199475 (1)
reticulin	57.03	5	1653908 (1), 11858401 (1), 2354404 (1), 15597767 (1) (see all 5)
hematoxylin	56.45	18	15725798 (3), 7512798 (1), 16949932 (1), 7506452 (1) (see all 15)
b 723	35.74	6	9808124 (1), 12481020 (1), 1693028 (1), 7678320 (1) (see all 6)
orcein	31.03	1	16796160 (1)
glycogen	24.17	3	8214396 (1), 8088719 (1), 15547779 (1)
calcium	23.63	171	8688416 (6), 9428666 (4), 8805590 (3), 15882069 (3) (see all 97)
progesterone	18.69	20	18414887 (2), 9720507 (1), 16608642 (1), 17309164 (1) (see all 18)
tyrosine	18.27	48	18073204 (4), 15681409 (4), 9705913 (3), 9218412 (2) (see all 30)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006272

Sigma-Aldrich siRNA and siRNA Panels for S100B

Sigma-Aldrich shRNA for S100B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006272

REFSEQ mRNAs for S100B gene:

NM_006272.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006272

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006272
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006272
                                 untagged cDNA clone in CMV expression vector: NM_006272

Additional cDNA sequence:

BC001766.1 BC041935.1 CR542123.1

12 DOTS entries:

DT.215194 DT.100758003 DT.95157592 DT.121136780 DT.95120732 DT.100758001 DT.121136796 DT.95157596

DT.100758004 DT.100758005 DT.121136789 DT.95157594

24/265 AceView cDNA sequences (see all 265 ):

AI339135 AW206771 AA831469 BI856702 AW137786 CR542123 BI494752 AI391682

CB054226 BE856467 AA808065 BM695249 BI496877 AW206399 BI756271 AA363992

BE465410 BU731627 BM694813 BI491621 AW022978 BU784451 AA321682 BG716672

highest scoring ESTs for S100B:

AA310307 AA317835 AA323417 AA379826 AA424102 AI459281 AI690125 BC001766 BC041935 BE275884

Unigene Cluster for S100B:

S100 calcium binding protein B

Hs.422181 [show with all ESTs]

Unigene Representative Sequence: BC041935

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for S100B (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	·	4d	·	4e
SP1:											-		-
SP2:											-
SP3:											-		-				-
SP4:									-		-		-				-
SP5:											-						-

About this scheme

ECgene alternative splicing isoforms for S100B

3 Ensembl transcripts including schematic representations:

ENST00000397648 ENST00000291700 ENST00000367071

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100B

¹ / ² / ³

4 probe-sets matching S100B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
235_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M59488	0.20	1.00	0.72	1
209686_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001766	0.80	1.00	0.91	1
1561521_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209686_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks S100B for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCGTGTAGA

SOURCE GeneReport for Unigene cluster: Hs.422181
Expression variation in blood from EXPOLDB for S100B
UniProtKB/Swiss-Prot: S100B_HUMAN, P04271
Tissue specificity: Although predominant among the water-soluble brain proteins, S100 is also found
in a variety of other tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100B gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S100B¹	--	S100 calcium binding protein B	78.62(n) 78.26(a)	491615 XM_548737.2 XP_548737.2
chimpanzee (Pan troglodytes)	S100B¹	--	S100 calcium binding protein B	98.91(n) 100(a)	474141 XM_001160520.1 XP_001160520.1
cow (Bos taurus)	S100B¹	--	S100 calcium binding protein B	90.22(n) 96.74(a)	525716 NM_001034555.2 NP_001029727.1
rat (Rattus norvegicus)	S100b¹	--	S100 calcium binding protein B	85.87(n) 97.83(a)	25742 NM_013191.1 NP_037323.1
mouse (Mus musculus)	S100b^{1, 5}	10 (41.00 cM)⁵	S100 protein, beta polypeptide, neural^{1, 5}	85.51(n)¹ 98.91(a)¹	20203¹ NM_009115.2¹ NP_033141.1¹ AC006507⁵ AI850290⁵ (see all 12)

About this table Species with no ortholog for S100B

ENSEMBL Gene Tree for S100B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/67 NCBI SNPs in S100B are shown (see all 67 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2839354^1,2	A,C,F,H,O	46843473(+)	`AGTCCC/ATGGGG`	1	--	ut3¹ ese³		8		NA EU EA WA	576
	rs2839365^1,2	A,C,F,H,O	46850374(+)	`CATCAG/CGTCCT`	1	--	ng3¹		5		NA EU EA WA	424
	rs9722^1,2	A,C,F,H	46843667(-)	`AGAGAC/TGGTCA`	1	--	ut3¹ ese³		17		MN NS EA NA EU WA	2574
	rs3788266^1,2	A,C,F,H	46850783(+)	`TGGCAG/ACCTGA`	1	--	ng3¹		9		EA EU WA	1932
	rs2839364^1,2	C,F,H,O	46850222(+)	`TCGCTC/TGACTG`	1	--	ng3¹		5		NA EU EA WA	434
	rs2839366^1,2	C,F,H,O	46850871(+)	`ACTCAT/AGCAAT`	1	--	ng3¹ tfbs³		5		NA EU EA WA	432
	rs9983698^1,2	C,F,H	46842971(+)	`TTGAAC/TGCAGG`	1	--	ut3¹ ese³		11		EU EA WA NA	980
	rs8128872^1,2	A,C	46849525(+)	`GCCGAA/GGGCGG`	1	--	ng3¹		0	--	--	--	--
	rs9980584^1,2	F,H	46842644(+)	`AAGCCG/ACGTTT`	1	--	ng5¹		2		EU WA	212
	rs9983317^1,2	H	46843228(+)	`TTGCAG/AGGCCA`	1	--	ut3¹		3		EU EA	300

About this table

HapMap Linkage Disequilibrium images for S100B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176990

10/96 Novoseek disease relationships for S100B gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myoepithelioma	81.94	4	1694334 (1), 8380682 (1), 1718079 (1), 8986967 (1)
melanoma	79.73	422	8791271 (5), 15234232 (5), 10570381 (5), 19104452 (5) (see all 99)
tumors	76.99	616	12759535 (4), 18454690 (4), 1380226 (4), 8986967 (4) (see all 99)
granular cell tumor	76.16	9	7817938 (1), 8878020 (1), 12579997 (1), 15590438 (1) (see all 8)
malignant peripheral nerve sheath tumors	75.88	7	11145248 (1), 11732802 (1), 17119986 (1), 18480004 (1) (see all 6)
mpnst	75.15	14	14508395 (3), 11580072 (1), 10584703 (1), 17910355 (1) (see all 9)
sarcoma clear cell	74.30	3	14666625 (1), 11211309 (1), 2004337 (1)
schwannoma	73.67	31	15487453 (2), 18480004 (2), 1710946 (2), 1708642 (2) (see all 21)
peripheral nerve sheath tumors	72.17	4	18636017 (2), 1656253 (1), 16327434 (1)
perineurioma	72.04	3	9221216 (1), 12459629 (1), 18434767 (1)

About this table

Genetic Association Database: S100B
Human Genome Epidemiology Navigator: S100B (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1549 PubMed articles for S100B gene (see all 1549 ):

Cloning and expression of the human S100 beta gene. (PubMed id 2394738)^{2, 3, 4} Allore R.J.... Marks A. (1990)
Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. (PubMed id 9925766)^{1, 3, 4} Yang Q.... Marks A. (1999)
SNPs and haplotypes in the S100B gene reveal association with schizophrenia. (PubMed id 15670788)^{3, 6} Liu J....He L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. (PubMed id 12480931)^{3, 4} McClintock K.A. and Shaw G.S. (2003)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. (PubMed id 9519411)^{3, 4} Smith S.P. and Shaw G.S. (1998)
Structure and chromosome assignment of human S100 alpha and beta subunit genes. (PubMed id 1998503)^{2, 3} Morii K....Kuwano R. (1991)
Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta. (PubMed id 4031854)^{3, 4} Jensen R.... Watterson D.M. (1985)
Purification, characterization and ion binding properties of human brain S100b protein. (PubMed id 6487634)^{3, 4} Baudier J.... Gerard D. (1984)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6285	HGNC: 10500	AceView: S100B	Ensembl:ENSG00000160307	euGenes: HUgn6285
ECgene: S100B	H-InvDB: S100B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for S100B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for S100B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S100B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100B		Antibodies for S100B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S100B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (S100B)
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	Chimera RNAi (S100B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (S100 beta, S100)
	Antibodies (S100 beta, S100)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for S100B

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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S100B Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for S100B

Summaries
for S100B

Genomic Location
for S100B

Proteins
for S100B

Protein Domains/
Families
for S100B

Gene Function
for S100B

Pathways & Interactions
for S100B

Drugs & Compounds
for S100B

Transcripts
for S100B

Expression
for S100B

Orthologs
for S100B

Paralogs
for S100B

SNPs/Variants
for S100B

Disorders & Mutations
for S100B

Medical News
for S100B

Publications
for S100B

Search for S100B

Genome Databases showing S100B

Other Databases showing S100B

Specialized Databases showing S100B

Licensable Technologies
for S100B

Services
for S100B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100B Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor S100B

Summariesfor S100B

Genomic Locationfor S100B

Proteinsfor S100B

Protein Domains/Familiesfor S100B

Gene Functionfor S100B

Pathways & Interactionsfor S100B

Drugs & Compoundsfor S100B

Transcriptsfor S100B

Expression for S100B

Orthologsfor S100B

Paralogsfor S100B

SNPs/Variantsfor S100B

Disorders & Mutationsfor S100B

Medical Newsfor S100B

Publicationsfor S100B

Search for S100B

Genome Databases showing S100B

Other Databases showing S100B

Specialized Databases showing S100B

Licensable Technologiesfor S100B

Servicesfor S100B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100B

Summaries
for S100B

Genomic Location
for S100B

Proteins
for S100B

Protein Domains/
Families
for S100B

Gene Function
for S100B

Pathways & Interactions
for S100B

Drugs & Compounds
for S100B

Transcripts
for S100B

Expression
for S100B

Orthologs
for S100B

Paralogs
for S100B

SNPs/Variants
for S100B

Disorders & Mutations
for S100B

Medical News
for S100B

Publications
for S100B

Licensable Technologies
for S100B

Services
for S100B