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Aliases for S100A8 Gene

Aliases for S100A8 Gene

  • S100 Calcium Binding Protein A8 2 3 5
  • S100 Calcium-Binding Protein A8 (Calgranulin A) 2 3
  • Migration Inhibitory Factor-Related Protein 8 3 4
  • Leukocyte L1 Complex Light Chain 3 4
  • Urinary Stone Protein Band A 3 4
  • Calprotectin L1L Subunit 3 4
  • Cystic Fibrosis Antigen 3 4
  • Calgranulin-A 3 4
  • MRP8 3 4
  • CAGA 3 4
  • CFAG 3 4
  • P8 3 4
  • S100 Calcium Binding Protein A8 (Calgranulin A) 2
  • S100 Calcium-Binding Protein A8 4
  • Calgranulin A 3
  • 60B8AG 3
  • CP-10 3
  • MA387 3
  • MRP-8 4
  • CGLA 3
  • L1Ag 3
  • MIF 3
  • NIF 3

External Ids for S100A8 Gene

Previous HGNC Symbols for S100A8 Gene

  • CAGA
  • CFAG

Previous GeneCards Identifiers for S100A8 Gene

  • GC01M151178
  • GC01M149145
  • GC01M150137
  • GC01M150579
  • GC01M150175
  • GC01M151629
  • GC01M153362
  • GC01M124725

Summaries for S100A8 Gene

Entrez Gene Summary for S100A8 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for S100A8 Gene

S100A8 (S100 Calcium Binding Protein A8) is a Protein Coding gene. Diseases associated with S100A8 include gastritis and cystic fibrosis. Among its related pathways are Platelet activation, signaling and aggregation and Spinal Cord Injury. GO annotations related to this gene include calcium ion binding and RAGE receptor binding.

UniProtKB/Swiss-Prot for S100A8 Gene

  • S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.

Gene Wiki entry for S100A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A8 Gene

Genomics for S100A8 Gene

Regulatory Elements for S100A8 Gene

Genomic Location for S100A8 Gene

Chromosome:
1
Start:
153,390,032 bp from pter
End:
153,422,578 bp from pter
Size:
32,547 bases
Orientation:
Minus strand

Genomic View for S100A8 Gene

Genes around S100A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A8 Gene

Proteins for S100A8 Gene

  • Protein details for S100A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05109-S10A8_HUMAN
    Recommended name:
    Protein S100-A8
    Protein Accession:
    P05109
    Secondary Accessions:
    • A8K5L3
    • D3DV37
    • Q5SY70
    • Q9UC84
    • Q9UC92
    • Q9UCJ0
    • Q9UCM6

    Protein attributes for S100A8 Gene

    Size:
    93 amino acids
    Molecular mass:
    10835 Da
    Quaternary structure:
    • Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A9 known as calprotectin (S100A8/A9). S100A8 interacts with AGER, ATP2A2 and with the heterodimeric complex formed by TLR4 and LY96 (By similarity). Interacts with GAPDH. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. S100A8 and calprotectin (S100A8/9) interact with NCF2/P67PHOX, RAC1 and RAC2. Calprotectin (S100A8/9) interacts with CYBA and CYBB. Calprotectin (S100A8/9) interacts with NOS2 to form the iNOS-S100A8/A9 transnitrosylase complex; induced by LDL(ox) (PubMed:25417112).
    Miscellaneous:
    • Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.

    Three dimensional structures from OCA and Proteopedia for S100A8 Gene

neXtProt entry for S100A8 Gene

Proteomics data for S100A8 Gene at MOPED

Post-translational modifications for S100A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A8 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for S100A8 Gene

Domains & Families for S100A8 Gene

Suggested Antigen Peptide Sequences for S100A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05109

UniProtKB/Swiss-Prot:

S10A8_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A8: view

Function for S100A8 Gene

Molecular function for S100A8 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A8,calgranulin A,epidermal differentiation complex
UniProtKB/Swiss-Prot Function:
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.

Gene Ontology (GO) - Molecular Function for S100A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,TAS 22489132
genes like me logo Genes that share ontologies with S100A8: view
genes like me logo Genes that share phenotypes with S100A8: view

Animal Models for S100A8 Gene

MGI Knock Outs for S100A8:

Animal Model Products

  • Taconic Biosciences Mouse Models for S100A8

miRNA for S100A8 Gene

miRTarBase miRNAs that target S100A8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A8 Gene

Localization for S100A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A8 Gene

Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A8 Gene COMPARTMENTS Subcellular localization image for S100A8 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
mitochondrion 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for S100A8 Gene

Pathways & Interactions for S100A8 Gene

genes like me logo Genes that share pathways with S100A8: view

Gene Ontology (GO) - Biological Process for S100A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production TAS 22489132
GO:0002526 acute inflammatory response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 19935772
GO:0018119 peptidyl-cysteine S-nitrosylation IMP 25417112
genes like me logo Genes that share ontologies with S100A8: view

No data available for SIGNOR curated interactions for S100A8 Gene

Drugs & Compounds for S100A8 Gene

(22) Drugs for S100A8 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(29) Additional Compounds for S100A8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A8: view

Transcripts for S100A8 Gene

Unigene Clusters for S100A8 Gene

S100 calcium binding protein A8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A8 Gene

No ASD Table

Relevant External Links for S100A8 Gene

GeneLoc Exon Structure for
S100A8
ECgene alternative splicing isoforms for
S100A8

Expression for S100A8 Gene

mRNA expression in normal human tissues for S100A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A8 Gene

This gene is overexpressed in Whole Blood (x17.2), Esophagus - Mucosa (x17.1), Vagina (x6.7), and Cervix - Ectocervix (x4.2).

Protein differential expression in normal tissues from HIPED for S100A8 Gene

This gene is overexpressed in Neutrophil (19.4), Monocytes (12.5), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S100A8 Gene



SOURCE GeneReport for Unigene cluster for S100A8 Gene Hs.416073

mRNA Expression by UniProt/SwissProt for S100A8 Gene

P05109-S10A8_HUMAN
Tissue specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohns disease, giant cell arteritis, cystic fibrosis, Sjogrens syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.
genes like me logo Genes that share expression patterns with S100A8: view

Protein tissue co-expression partners for S100A8 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for S100A8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A8 35
  • 80.52 (n)
  • 71.91 (a)
S100A8 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A8 35
  • 82.77 (n)
  • 76.4 (a)
S100A8 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100a8 35
  • 70.79 (n)
  • 58.43 (a)
S100a8 16
S100a8 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100A8 35
  • 98.57 (n)
  • 100 (a)
S100A8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a8 35
  • 71.91 (n)
  • 62.92 (a)
oppossum
(Monodelphis domestica)
Mammalia S100A8 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100A8 36
  • 46 (a)
OneToOne
Species with no ortholog for S100A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A8 Gene

ENSEMBL:
Gene Tree for S100A8 (if available)
TreeFam:
Gene Tree for S100A8 (if available)

Paralogs for S100A8 Gene

(22) SIMAP similar genes for S100A8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A8: view

No data available for Paralogs for S100A8 Gene

Variants for S100A8 Gene

Sequence variations from dbSNP and Humsavar for S100A8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2148318 -- 153,403,260(+) ttgtg(C/T)gtatg intron-variant
rs2860565 -- 153,405,739(+) tggac(A/G)taaaa intron-variant
rs2860566 -- 153,405,767(+) CCACC(A/G)ACTCT intron-variant
rs3014807 -- 153,395,544(+) TCCTC(A/G/T)TCACA intron-variant
rs3014808 -- 153,398,189(+) AGCAG(C/T)ACCCC intron-variant

Variation tolerance for S100A8 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A8 Gene

HapMap Linkage Disequilibrium report
S100A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A8 Gene

Disorders for S100A8 Gene

MalaCards: The human disease database

(19) MalaCards diseases for S100A8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastritis
  • acute gastric mucosal erosion
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
duodenal ulcer
  • curling ulcer
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
atrophic gastritis
  • gastric atrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A8

Genetic Association Database (GAD)
S100A8
Human Genome Epidemiology (HuGE) Navigator
S100A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A8
genes like me logo Genes that share disorders with S100A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A8 Gene

Publications for S100A8 Gene

  1. Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. (PMID: 1326551) Lemarchand P. … Markert M. (J. Biol. Chem. 1992) 3 4 23 67
  2. Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. (PMID: 19087201) Sroussi H.Y. … Palefsky J.M. (FEMS Immunol. Med. Microbiol. 2009) 3 23
  3. S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. (PMID: 19670424) NAcmeth J. … Hess J. (Hepatology 2009) 3 23
  4. Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus. (PMID: 19755614) Soyfoo M.S. … Decaux G. (J. Rheumatol. 2009) 3 23
  5. Epithelial genes in chronic rhinosinusitis with and without nasal polyps. (PMID: 18588753) Richer S.L. … Schleimer R.P. (Am J Rhinol 2008) 3 23

Products for S100A8 Gene

Sources for S100A8 Gene

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