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S100A8 Gene

protein-coding GIFtS: 62

GC01M151629

S100 calcium binding protein A8
(Previous names: S100 calcium-binding protein A8 (calgranulin A), S100 calcium binding protein A8 (calgranulin A) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CAGA, CFAG)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
60B8AG ^¹, ²
CAGA ^², ³, ⁵
CFAG ^², ³, ⁵
CGLA ^¹, ²
CP-10 ^²
Calgranulin-A ^³
L1Ag ^²
MA387 ^²
MIF ^²
MRP-8 ^³
MRP8 ^¹, ², ³
NIF ^²
OTTHUMP00000015329 ^²
OTTHUMP00000015330 ^²
P8 ^¹, ², ³

Descriptions
Calprotectin L1L subunit ^³
Cystic fibrosis antigen ^², ³
Leukocyte L1 complex light chain ^³
Migration inhibitory factor-related protein 8 ^³
S100 calcium binding protein A8 ^²
S100 calcium binding protein A8 (calgranulin A) ^¹
S100 calcium-binding protein A8 ^², ³
S100 calcium-binding protein A8 (calgranulin A) ^¹, ²
Urinary stone protein band A ^³
calgranulin A ^²

External Ids
HGNC: 10498¹
Entrez Gene: 6279²
UniProtKB: P05109³
Ensembl: ENSG00000143546⁷

Search outside databases for aliases for S100A8 gene

Previous GC identifers: GC01M151178 GC01M149145 GC01M150137 GC01M150579 GC01M150175

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A8:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand

calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide

range of cells, and involved in the regulation of a number of cellular processes such as cell

cycle progression and differentiation. S100 genes include at least 13 members which are located as

a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as

a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

[provided by RefSeq]

UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109

Function: Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells

constitutively or induced during dermatoses. May interact with components of the intermediate

filaments in monocytes and epithelial cells

Gene Wiki entry for S100A8 (S100_calcium_binding_protein_A8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the S100A8 gene

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q12-q22

S100A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M151629: (about GC identifiers)

Start:	151,629,132 bp from pter
End:	151,630,173 bp from pter
Size:	1,042 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109 (See protein sequence)

Recommended Name: Protein S100-A8

Size: 93 amino acids; 10835 Da

Subunit: Homodimer

Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S100

proteins

PDB structure from and Proteopedia :

1MR8 (3D)

1XK4 (3D)

Secondary accessions: A8K5L3 Q5SY70 Q9UC84 Q9UC92 Q9UCJ0 Q9UCM6

REFSEQ proteins: NP_002955.2

ENSEMBL proteins:

ENSP00000357722 ENSP00000357721

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Macrophage L1 protein Calprotectin, MRP8 + MRP14, MRP8)
	Human Recombinant Proteins from Abnova (S100A8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for S100A8:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of S100A8
	Sigma-Aldrich Antibodies for S100A8
	R&D Systems Antibodies for S100A8
	Antibodies from Abcam (Macrophage L1 protein Calprotectin, MRP8 + MRP14, MRP8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S100A8)
	Novus Biologicals Antibodies for S100A8

Assays for S100A8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05109

ProtoNet protein and cluster: P05109

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002964

Applied Biosystems Silencer® siRNAs for S100A8

Sigma-Aldrich siRNA for S100A8

Sigma-Aldrich shRNA for S100A8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100A8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002964
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002964
untagged cDNA clone in CMV expression vector: NM_002964

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002964

UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109

Function: Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells

constitutively or induced during dermatoses. May interact with components of the intermediate

filaments in monocytes and epithelial cells

Genatlas biochemistry entry for S100A8:

S100 calcium binding protein A8,calgranulin A,epidermal differentiation complex

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for S100a8):

embryogenesis

lethality-prenatal/perinatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	TAS	2149559
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for S100A8

5/57 Interacting proteins for S100A8 (ENSP00000357722³ P05109^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRMT1	Q99873²	STRING (score=.901) MINT-63397
LRRK1	Q38SD2¹	EBI-355281, EBI-1050422
MOBKL1B	Q9H8S9¹	EBI-355281, EBI-748229
NUAK1	O60285¹	EBI-355281, EBI-1046789
PPM1B	O75688¹	EBI-355281, EBI-1047039

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	3313057

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A8
10/31 Novoseek chemical compound relationships for S100A8 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atpa	53.36	1	12748272 (1)
scca1	44.14	1	17638865 (1)
tyrosine	32.02	117	12752736 (9), 11929545 (5), 12925139 (5), 11777849 (4) (see all 39)
urea	29.37	8	9746590 (1), 15377296 (1), 19399945 (1), 18334875 (1) (see all 7)
monosodium urate	20.89	2	12905486 (2)
8-oxo-dg	17.51	8	11989831 (1), 12752735 (1), 19081768 (1), 17127715 (1)
oligonucleotide	12.41	14	15198928 (2), 15280402 (1), 9398887 (1), 11417307 (1) (see all 9)
crcs	11.90	1	12353842 (1)
flagellin	8.99	3	19399945 (1), 8152375 (1), 10660136 (1)
superoxide	4.68	2	14708622 (2)

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2 PharmGKB drug compound relationships for S100A8 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002964

Sigma-Aldrich siRNA for S100A8

Sigma-Aldrich shRNA for S100A8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002964

REFSEQ mRNAs for S100A8 gene:

NM_002964.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002964

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002964
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002964
                                 untagged cDNA clone in CMV expression vector: NM_002964

Additional cDNA sequence:

AK291328.1 BC005928.2 BT007378.1 CR407674.1 X06234.1 Y00278.1

17 DOTS entries:

DT.97864015 DT.91911261 DT.91765796 DT.100877161 DT.95110289 DT.100877152 DT.95351910 DT.100877151

DT.100877153 DT.100877155 DT.91765792 DT.121432976 DT.121432975 DT.91892881 DT.95351901 DT.91738911

DT.95325317

24/431 AceView cDNA sequences (see all 431 ):

BM955350 AW304434 BM855179 AJ706285 BM955383 BM955359 AW275844 CR407674

CB129405 AI187047 BM955355 AA321357 AA321386 BM955362 AI804862 AI826354

BM955353 F25314 AA321530 BT007378 AJ705422 F33754 T99218 CF530015

highest scoring ESTs for S100A8:

AA321180 AI126134 AV712109 AV712835 AV713378 AV715560 AV735754 AV755464 AV757679 BE185239

Unigene Cluster for S100A8:

S100 calcium binding protein A8

Hs.416073 [show with all ESTs]

Unigene Representative Sequence: BG739729

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000368733 ENST00000368732

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100A8

¹ / ² / ³

3 probe-sets matching S100A8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41096_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AI126134	0.80	1.00	0.91	1
202917_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002964	0.60	1.00	0.82	1
202917_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks S100A8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACCTGCAGA

SOURCE GeneReport for Unigene cluster: Hs.416073
Expression variation in blood from EXPOLDB for S100A8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100A8 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S100A8¹	--	S100 calcium binding protein A8	82.77(n) 76.4(a)	490461 XM_547583.2 XP_547583.2
chimpanzee (Pan troglodytes)	S100A8¹	--	S100 calcium binding protein A8	98.57(n) 100(a)	457319 XM_001138242.1 XP_001138242.1
cow (Bos taurus)	S100A8¹	--	S100 calcium binding protein A8	80.52(n) 71.91(a)	616818 XM_868934.2 XP_874027.1
rat (Rattus norvegicus)	S100a8¹	--	S100 calcium binding protein A8	71.54(n) 62.92(a)	116547 NM_053822.1 NP_446274.1
mouse (Mus musculus)	S100a8^{1, 5}	3 (43.60 cM)⁵	S100 calcium binding protein A8 (calgranulin A)^{1, 5}	70.79(n)¹ 58.43(a)¹	20201¹ NM_013650.2¹ NP_038678.1¹ AA111306⁵ AI429437⁵ (see all 12)

About this table Species with no ortholog for S100A8

ENSEMBL Gene Tree for S100A8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S100A8 gene

S100A12² S100P² S100A9²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/22 NCBI SNPs in S100A8 are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3006488^1,2	A,C,F,H,O	151629131(+)	`GAGGCA/GTGAGG`	1	--	ng5¹		6	EU EA WA	598
	rs11205281^1,2	A,C,F,H	151631286(+)	`aaagaC/Ttcaaa`	1	--	ng3¹		4	EU EA WA	416
	rs6659104^1,2	A,C,F,H	151628770(+)	`ATCACT/CCTAAT`	1	--	ng5¹		6	NA EU EA	418
--	rs3806232^1,2	A,C,F,H	151630754(+)	`GTTGTT/CGCCAA`	1	--	ng3¹		9	NA MN EA EU WA	906
	rs11205282^1,2	A,C,F,H	151631934(+)	`CTCTCT/CGGATG`	1	--	ng3¹		4	EU EA WA	412
	rs12040625^1,2	C,F,H	151632172(+)	`CCCACA/GGAGAG`	1	--	ng3¹		4	EU EA WA	394
	rs7545728^1,2	F,H	151628875(+)	`ATCCCC/TGACCC`	1	--	ng5¹		4	EU EA WA	418
	rs11585892^1,2	H	151630961(+)	`GGATCA/GCTGGC`	1	--	ng3¹		4	EU EA WA	418
	rs3885688^1,2	H	151631966(-)	`GCTGGG/ACACTG`	1	--	ng3¹		4	EU EA WA	408
--	rs3795391^1,2	F	151629729(+)	`GAGGAT/CTCATG`	1	--	int¹		1	EA	1474

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HapMap Linkage Disequilibrium images for S100A8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123885

10/95 Novoseek disease relationships for S100A8 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gastritis	91.38	171	9398887 (5), 17890898 (4), 8586721 (3), 16302986 (3) (see all 99)
peptic ulcer	89.15	151	10861258 (5), 10823130 (5), 9619383 (4), 9759946 (4) (see all 81)
duodenal ulcer	88.40	84	10548360 (3), 16543737 (3), 9398887 (3), 9577374 (3) (see all 54)
gastritis chronic	87.19	47	12640706 (3), 11780331 (3), 10823130 (3), 19405980 (2) (see all 29)
gastric cancer	83.02	139	14724815 (8), 9659265 (4), 15300891 (3), 10363680 (3) (see all 79)
gastric ulcer	80.75	41	11158115 (3), 7650174 (2), 11519793 (2), 12645789 (2) (see all 23)
adenocarcinoma gastric	78.36	38	12752736 (5), 10189841 (4), 9286230 (2), 11427555 (2) (see all 19)
duodenal ulcer disease	78.12	19	12697114 (2), 11843964 (2), 11158115 (2), 12734242 (1) (see all 9)
gastritis atrophic	75.27	19	17760724 (3), 12925139 (2), 10364597 (1), 9146793 (1) (see all 12)
metaplasia	72.06	24	11288377 (3), 9691913 (2), 9517643 (2), 12663641 (2) (see all 18)

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1 PharmGKB disease relationship for S100A8 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

About this table

Human Genome Epidemiology Navigator: S100A8 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/676 PubMed articles for S100A8 gene (see all 676 ):

Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. (PubMed id 1326551)^{1, 3, 4} Lemarchand P.... Markert M. (1992)
Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PubMed id 8619876)^{1, 3, 4} Marti T.... Gallin M.Y. (1996)
The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells. (PubMed id 2039599)^{1, 3, 4} Schaefer T.... Gassen H.G. (1991)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution. (PubMed id 10771424)^{3, 4} Ishikawa K.... Nishihira J. (2000)
Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone. (PubMed id 7849642)^{3, 4} Umekawa T. and Kurita T. (1994)
In vitro antimicrobial activity of the human neutrophil cytosolic S- 100 protein complex, calprotectin, against Capnocytophaga sputigena. (PubMed id 8423249)^{3, 4} Miyasaki K.T.... Lehrer R.I. (1993)
Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)^{3, 4} Rasmussen H.H....Vandekerckhove J. (1992)
Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation. (PubMed id 3405210)^{3, 4} Lagasse E. and Clerc R.G. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6279	HGNC: 10498	AceView: S100A8	Ensembl:ENSG00000143546	euGenes: HUgn6279
ECgene: S100A8	H-InvDB: S100A8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for S100A8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S100A8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100A8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100A8		Antibodies for S100A8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S100A8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Recombinant Proteins (Macrophage L1 protein Calprotectin, MRP8 + MRP14, MRP8)
	Antibodies (Macrophage L1 protein Calprotectin, MRP8 + MRP14, MRP8)

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Search Tocris compounds for S100A8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
S100A8 Gene at Home site.
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S100A8 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for S100A8

Summaries
for S100A8

Genomic Location
for S100A8

Proteins
for S100A8

Protein Domains/
Families
for S100A8

Gene Function
for S100A8

Pathways & Interactions
for S100A8

Drugs & Compounds
for S100A8

Transcripts
for S100A8

Expression
for S100A8

Orthologs
for S100A8

Paralogs
for S100A8

SNPs/Variants
for S100A8

Disorders & Mutations
for S100A8

Medical News
for S100A8

Publications
for S100A8

Search for S100A8

Genome Databases showing S100A8

Other Databases showing S100A8

Specialized Databases showing S100A8

Licensable Technologies
for S100A8

Services
for S100A8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100A8 (Gene Symbol)
60B8AG
CAGA
CFAG
CGLA
CP-10
Calgranulin-A
L1Ag
MA387
MIF
MRP-8
MRP8
NIF
OTTHUMP00000015329
OTTHUMP00000015330
P8
Calprotectin L1L subunit
Cystic fibrosis antigen
Leukocyte L1 complex light chain
Migration inhibitory factor-related protein 8
S100 calcium binding protein A8
S100 calcium binding protein A8 (calgranulin A)
S100 calcium-binding protein A8
S100 calcium-binding protein A8 (calgranulin A)
Urinary stone protein band A
calgranulin A

S100A8 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor S100A8

Summariesfor S100A8

Genomic Locationfor S100A8

Proteinsfor S100A8

Protein Domains/Familiesfor S100A8

Gene Functionfor S100A8

Pathways & Interactionsfor S100A8

Drugs & Compoundsfor S100A8

Transcriptsfor S100A8

Expression for S100A8

Orthologsfor S100A8

Paralogsfor S100A8

SNPs/Variantsfor S100A8

Disorders & Mutationsfor S100A8

Medical Newsfor S100A8

Publicationsfor S100A8

Search for S100A8

Genome Databases showing S100A8

Other Databases showing S100A8

Specialized Databases showing S100A8

Licensable Technologiesfor S100A8

Servicesfor S100A8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100A8

Summaries
for S100A8

Genomic Location
for S100A8

Proteins
for S100A8

Protein Domains/
Families
for S100A8

Gene Function
for S100A8

Pathways & Interactions
for S100A8

Drugs & Compounds
for S100A8

Transcripts
for S100A8

Expression
for S100A8

Orthologs
for S100A8

Paralogs
for S100A8

SNPs/Variants
for S100A8

Disorders & Mutations
for S100A8

Medical News
for S100A8

Publications
for S100A8

Licensable Technologies
for S100A8

Services
for S100A8