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S100A8 Gene

protein-coding   GIFtS: 62
GCID: GC01M153362

S100 Calcium Binding Protein A8

(Previous names: S100 calcium-binding protein A8 (calgranulin A), S100 calcium...)
(Previous symbols: CAGA, CFAG)
  See S100A8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A81 2     CGLA2
CAGA1 2 3 5     CP-102
CFAG1 2 3 5     L1Ag2
S100 Calcium-Binding Protein A8 (Calgranulin A)1 2     MA3872
Calprotectin L1L Subunit2 3     MIF2
Cystic Fibrosis Antigen2 3     NIF2
Leukocyte L1 Complex Light Chain2 3     P82
Migration Inhibitory Factor-Related Protein 82 3     Calgranulin A2
Urinary Stone Protein Band A2 3     calgranulin-A2
MRP-82 3     Protein S100-A82
MRP82 3     Calgranulin-A3
S100 Calcium Binding Protein A8 (Calgranulin A)1     p83
60B8AG2     S100 Calcium-Binding Protein A83

External Ids:    HGNC: 104981   Entrez Gene: 62792   Ensembl: ENSG000001435467   OMIM: 1238855   UniProtKB: P051093   

Export aliases for S100A8 gene to outside databases

Previous GC identifers: GC01M151178 GC01M149145 GC01M150137 GC01M150579 GC01M150175 GC01M151629 GC01M124725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A8 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the
inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease
cystic fibrosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100A8 Gene:
S100A8 (S100 calcium binding protein A8) is a protein-coding gene. Diseases associated with S100A8 include duodenal disease, and duodenitis. GO annotations related to this gene include RAGE receptor binding and calcium ion binding.

UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
Function: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of
inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found
as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular
functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the
tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic
acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly
binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging
and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of
cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a
danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern
recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER).
Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the
amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts
its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce
cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via
reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an
anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving
MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by
scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer
development and tumor spread

Gene Wiki entry for S100A8 (S100 calcium binding protein A8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A8 gene promoter:
         RFX1   AML1a   Tal-1   MyoD   Lmo2   LCR-F1   E47   GATA-1   HOXA5   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A8 promoter sequence
   Search Chromatin IP Primers for S100A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q12-q22

S100A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153362:  view genomic region     (about GC identifiers)

Start:
153,362,508 bp from pter      End:
153,363,664 bp from pter
Size:
1,157 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109 (See protein sequence)
Recommended Name: Protein S100-A8  
Size: 93 amino acids; 10835 Da
Subunit: Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A9 known as calprotectin
(S100A8/A9). S100A8 interacts with AGER, ATP2A2 and with the heterodimeric complex formed by TLR4 and LY96 (By
similarity). Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner.
Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated
monocytes. S100A8 and calprotectin (S100A8/9) interact with NCF2/P67PHOX, RAC1 and RAC2. Calprotectin (S100A8/9)
interacts with CYBA and CYBB
Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins
3 PDB 3D structures from and Proteopedia for S100A8:
1MR8 (3D)        1XK4 (3D)        4GGF (3D)    
Secondary accessions: A8K5L3 D3DV37 Q5SY70 Q9UC84 Q9UC92 Q9UCJ0 Q9UCM6

Explore the universe of human proteins at neXtProt for S100A8: NX_P05109

Explore proteomics data for S100A8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See S100A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002955.2  
    ENSEMBL proteins: 
     ENSP00000357721   ENSP00000357722  

    S100A8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for S100A8

     
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    antibodies-online proteins for S100A8 (45 products) 

     
    antibodies-online peptides for S100A8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    Selected InterPro protein domains (see all 6):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR028474 S100A8
     IPR013787 S100_Ca-bd_sub
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P05109

    ProtoNet protein and cluster: P05109

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Find genes that share domains with S100A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S10A8_HUMAN, P05109
    Function: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of
    inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found
    as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular
    functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the
    tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
    Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic
    acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly
    binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging
    and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of
    cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a
    danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern
    recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER).
    Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the
    amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts
    its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce
    cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via
    reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an
    anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving
    MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by
    scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer
    development and tumor spread

         Genatlas biochemistry entry for S100A8:
    S100 calcium binding protein A8,calgranulin A,epidermal differentiation complex

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS--
    GO:0005515protein binding IPI--
    GO:0008017microtubule binding TAS--
    GO:0008270zinc ion binding TAS--
    GO:0035662Toll-like receptor 4 binding TAS--
         
    Find genes that share ontologies with S100A8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for S100A8:
     Increased G2M DNA content  Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S100a8):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with S100A8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for S100A8: S100a8tm1Hume S100a8tm1Hogg

       genOway: Develop your customized and physiologically relevant rodent model for S100A8

    miRNA
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    miRTarBase miRNAs that target S100A8:
    hsa-mir-125b-5p (MIRT045918), hsa-mir-98-5p (MIRT027768)

    Block miRNA regulation of human, mouse, rat S100A8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate S100A8 (see all 11):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-miR-1205 hsa-let-7g hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat S100A8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S10A8_HUMAN, P05109: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.
    Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated
    from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion
    of monocytes, is secreted via a microtubule-mediated, alternative pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    extracellular5
    plasma membrane5
    mitochondrion2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with S100A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S100A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of C EBPbeta
    Selected targets of C EBPbeta

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for S100A8
        MIF Regulation of Innate Immune Cells
    MIF Mediated Glucocorticoid Regulation
    MIF Action Through Endocytic Pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including S100A8 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for S100A8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for S100A8 (P051091, 2, 3 ENSP000003577214) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-63391 I2D: score=5 STRING: ENSP00000269305
    C14orf1Q9UKR52, 3MINT-63401 I2D: score=5 
    CHGBP050602, 3MINT-63392 I2D: score=5 
    GDF9O603832, 3MINT-63390 I2D: score=5 
    PDCD11Q146902, 3MINT-63394 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production TAS--
    GO:0002523leukocyte migration involved in inflammatory response IDA12626582
    GO:0002526acute inflammatory response IEA--
    GO:0002544chronic inflammatory response IEA--
    GO:0006914autophagy IDA19935772

    Find genes that share ontologies with S100A8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for S100A8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    1 HMDB Compound for S100A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for S100A8 gene (see all 51)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clarithromycin 59.5 15 17205045 (3), 11326028 (2), 11302817 (1), 12385434 (1) (see all 10)
    atpa 51.6 1 12748272 (1)
    amoxicillin 42.9 7 12425876 (2), 10378418 (1), 12385434 (1), 10855013 (1) (see all 5)
    scca1 42.1 1 17638865 (1)
    metronidazole 39.6 7 19604178 (2), 10378418 (1), 16038520 (1), 11390701 (1) (see all 5)
    tyrosine 32.4 123 12752736 (9), 11929545 (5), 12925139 (5), 11777849 (4) (see all 43)
    urea 25.2 7 9746590 (1), 15377296 (1), 18334875 (1), 10340709 (1) (see all 6)
    omeprazole 23.9 2 12385434 (1), 12425876 (1)
    tazarotene 23.4 1 9325272 (1)
    monosodium urate 17.9 2 12905486 (2)



    Find genes that share compounds with S100A8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for S100A8 gene: 
    NM_002964.4  

    Unigene Cluster for S100A8:

    S100 calcium binding protein A8
    Hs.416073  [show with all ESTs]
    Unigene Representative Sequence: BG739729
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368732 ENST00000368733(uc001fbs.3) ENST00000477801
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat S100A8
      QuantiFast Probe-based Assays in human, mouse, rat S100A8

    Additional mRNA sequence: 

    AK291328.1 BC005928.2 BT007378.1 CR407674.1 X06234.1 Y00278.1 

    19 DOTS entries:

    DT.97864015  DT.91911261  DT.91765796  DT.100877161  DT.95110289  DT.100877152  DT.95351910  DT.100877151 
    DT.100877153  DT.100877155  DT.91765792  DT.121432975  DT.121432976  DT.91738911  DT.95351901  DT.75189937 
    DT.91965391  DT.95325317  DT.95375948 

    Selected AceView cDNA sequences (see all 431):

    AJ714143 AW628258 AW265340 BM955351 BM955347 F33754 BC005928 AW468109 
    BM855179 AI187047 AW080385 AJ713934 AA321386 BM955358 AJ705229 BQ448497 
    BT007378 AW304434 BM955352 AI826354 BM955350 AI804862 AA314576 BM955376 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S100A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTGCAGA
    S100A8 Expression
    About this image


    S100A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells (family)
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    S100A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S100A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416073

    UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
    Tissue specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory
    conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are
    expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes.
    Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the
    epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with
    inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant
    cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic
    sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea
    inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder,
    ovarian, thyroid, breast and skin cancers

        Pathway & Disease-focused RT2 Profiler PCR Arrays including S100A8 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for S100A8 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a81 , 5 S100 calcium binding protein A8 (calgranulin A)1, 5 70.79(n)1
    58.43(a)1
      3 (39.90 cM)5
    202011  NM_013650.21  NP_038678.11 
     906690715 


    ENSEMBL Gene Tree for S100A8 (if available)
    TreeFam Gene Tree for S100A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S100A8 gene
    Selected SIMAP similar genes for S100A8 using alignment to 1 protein entry:     S10A8_HUMAN(see all similar genes):
    S100B    HRNR    RPTN    S100G    FLG    S100A5
    S100P    S100A1    S100A11    S100A4    S100A9    S100A13
    TCHH    S100A10    S100A12    S100A6    FLG2    S100A2

    Find genes that share paralogs with S100A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S100A8 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs604738301,2
    C,F--153362105(+) CACAGG/ACACAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1420183391,2
    C--153362105(+) CACAG-/ACACACA 1 -- ds50010--------
    rs66591041,2
    C,F,A,H--153362146(+) ATCACT/CCTAAT 1 -- ds500124Minor allele frequency- C:0.18NA NS EA WA CSA 2452
    rs1862393871,2
    --153362189(+) GAAGCC/TAAAAT 1 -- ds50010--------
    rs1901549491,2
    --153362220(+) AGTTGC/TTCTTA 1 -- ds50010--------
    rs75457281,2
    C,F,H--153362251(+) ATCCCC/TGACCC 1 -- ds50018Minor allele frequency- T:0.01NS EA NA WA 922
    rs1821401511,2
    --153362293(+) TAGTGG/TCATGG 1 -- ds50010--------
    rs1381771541,2
    --153362301(+) TGGACG/TTTTTG 1 -- ds50010--------
    rs592016461,2
    C,F--153362423(+) ATAACA/TTAGAT 1 -- ds50012Minor allele frequency- T:0.03WA 120
    rs1867445901,2
    C--153362446(+) CTTTGG/TGTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for S100A8 (153362508 - 153363664 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for S100A8: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A8
    DNA2.0 Custom Variant and Variant Library Synthesis for S100A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123885    OMIM disorders: --

    8 diseases for S100A8:    
    About MalaCards
    duodenal disease    duodenitis    funisitis    relapsing polychondritis
    cardiac sarcoidosis    cystic fibrosis    gastritis    gallbladder disease

    2 diseases from the University of Copenhagen DISEASES database for S100A8:
    Psoriasis     Arthritis

    Find genes that share disorders with S100A8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for S100A8 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastritis 91.6 174 9398887 (5), 17890898 (4), 8586721 (3), 16302986 (3) (see all 99)
    peptic ulcer 89.5 159 10861258 (5), 10823130 (5), 9619383 (4), 9759946 (4) (see all 86)
    duodenal ulcer 88.7 90 10548360 (3), 16543737 (3), 19710266 (3), 9398887 (3) (see all 56)
    gastritis chronic 88 53 20136573 (4), 12640706 (3), 10823130 (3), 11780331 (3) (see all 31)
    gastric cancer 83.8 166 14724815 (8), 19685530 (5), 9659265 (4), 15300891 (3) (see all 91)
    gastric ulcer 81.9 43 11158115 (3), 7650174 (2), 11519793 (2), 12645789 (2) (see all 25)
    adenocarcinoma gastric 79 42 12752736 (5), 10189841 (4), 9286230 (2), 11427555 (2) (see all 20)
    duodenal ulcer disease 77.8 19 12697114 (2), 11843964 (2), 11158115 (2), 12734242 (1) (see all 9)
    gastritis atrophic 75.8 20 17760724 (3), 12925139 (2), 10364597 (1), 9146793 (1) (see all 13)
    metaplasia 72.3 25 11288377 (3), 9691913 (2), 9517643 (2), 12663641 (2) (see all 19)

    Genetic Association Database (GAD): S100A8
    Human Genome Epidemiology (HuGE) Navigator: S100A8 (5 documents)

    Export disorders for S100A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S100A8 gene, integrated from 10 sources (see all 850):
    (articles sorted by number of sources associating them with S100A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. (PubMed id 1326551)1, 2, 9 Lemarchand P.... Markert M. (J. Biol. Chem. 1992)
    2. Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. (PubMed id 19087201)1, 2, 9 Sroussi H.Y.... Palefsky J.M. (FEMS Immunol. Med. Microbiol. 2009)
    3. Correlation between single nucleotide polymorphisms in a calprotectin subunit gene and risk of periodontitis in a Chinese population. (PubMed id 17069562)1, 4, 9 Li Q....Cao C. (Ann. Hum. Genet. 2007)
    4. Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PubMed id 8619876)1, 2, 9 Marti T.... Gallin M.Y. (Biochem. Biophys. Res. Commun. 1996)
    5. The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells. (PubMed id 2039599)1, 2, 9 Schaefer T.... Gassen H.G. (Biol. Chem. Hoppe-Seyler 1991)
    6. S100A8 and S100A9: new insights into their roles in malignancy. (PubMed id 21912088)1, 2 Srikrishna G. (J. Innate Immun. 2012)
    7. Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation. (PubMed id 22808130)1, 2 Berthier S.... Morel F. (PLoS ONE 2012)
    8. Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway. (PubMed id 22363402)1, 2 Atallah M.... Mevorach D. (PLoS ONE 2012)
    9. Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients. (PubMed id 21067798)1, 4 Rungroj N....Yenchitsomanus P.T. (Urology 2011)
    10. S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. (PubMed id 19935772)1, 2 Ghavami S.... Los M. (Cell Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6279 HGNC: 10498 AceView: S100A8 Ensembl:ENSG00000143546 euGenes: HUgn6279
    ECgene: S100A8 H-InvDB: S100A8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S100A8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S100A8 gene:
    Search GeneIP for patents involving S100A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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