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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100A8 Gene

protein-coding   GIFtS: 63
GCID: GC01M153362

S100 calcium binding protein A8

(Previous names: S100 calcium-binding protein A8 (calgranulin A), S100 calcium...)
(Previous symbols: CAGA, CFAG)
 Explore 131 diseases affiliated with
S100A8 via
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Biological research products
for S100A8    

Aliases
for S100A8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
S100 Calcium Binding Protein A81 2     MRP-82 3
CAGA1 2 3 5     S100 Calcium Binding Protein A8 (Calgranulin A)1
CFAG1 2 3 5     CP-102
MRP81 2 3     L1Ag2
60B8AG1 2     MA3872
CGLA1 2     MIF2
P81 2     NIF2
S100 Calcium-Binding Protein A8 (Calgranulin A)1 2     Calgranulin A2
Calprotectin L1L Subunit2 3     Calgranulin-A3
Cystic Fibrosis Antigen2 3     Protein S100-A82
Leukocyte L1 Complex Light Chain2 3     Calgranulin-A3
Migration Inhibitory Factor-Related Protein 82 3     P81 2
Urinary Stone Protein Band A2 3     S100 Calcium-Binding Protein A83

External Ids:    HGNC: 104981   Entrez Gene: 62792   Ensembl: ENSG000001435467   OMIM: 1238855   UniProtKB: P051093   

Export aliases for S100A8 gene to outside databases

Previous GC identifers: GC01M151178 GC01M149145 GC01M150137 GC01M150579 GC01M150175 GC01M151629 GC01M124725


Summaries
for S100A8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for S100A8:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at
least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of
casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
Function: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory
processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin
(S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include:
facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton
during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by
facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to
the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The
extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.
Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and
regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP)
molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4
(TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and
NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial
activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is
essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the
cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can
regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4
and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing
exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as
well as in cancer development and tumor spread

Gene Wiki entry for S100A8 (S100 calcium binding protein A8)


Genomic Views
for S100A8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100A8 gene promoter:
         RFX1   AML1a   Tal-1   MyoD   Lmo2   LCR-F1   E47   GATA-1   HOXA5   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for S100A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q12-q22

S100A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153362:  view genomic region     (about GC identifiers)

Start:
 153,362,508 bp from pter      End:
 153,363,664 bp from pter
Size:
 1,157 bases      Orientation:
 minus strand

Proteins
for S100A8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109 (See protein sequence)
Recommended Name: Protein S100-A8  
Size: 93 amino acids; 10835 Da
Subunit: Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A9 known as calprotectin
(S100A8/A9). S100A8 interacts with AGER, ATP2A2 and with the heterodimeric complex formed by TLR4 and LY96 (By
similarity). Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner.
Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated
monocytes. S100A8 and calprotectin (S100A8/9) interact with NCF2/P67PHOX, RAC1 and RAC2. Calprotectin (S100A8/9)
interacts with CYBA and CYBB
Subcellular location: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.
Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from
the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of
monocytes, is secreted via a microtubule-mediated, alternative pathway
Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins
2 PDB 3D structures from and Proteopedia for S100A8:
1MR8 (3D)        1XK4 (3D)    
Secondary accessions: A8K5L3 D3DV37 Q5SY70 Q9UC84 Q9UC92 Q9UCJ0 Q9UCM6

Explore the universe of human proteins at neXtProt for S100A8: NX_P05109

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05109

    • S100A8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002955.2  
    ENSEMBL proteins: 
     ENSP00000357722   ENSP00000357721  

    Human Recombinant Protein Products: 
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    Novus Biologicals S100A8 Lysates
    Sino Biological Recombinant Protein for S100A8
    ProSpec Recombinant Protein for S100A8
    Uscn Proteins for S100A8

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS--


    S100A8 for ontologies           About GeneDecksing



    S100A8 Antibody Products: 
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    Uscn ELISAs and CLIAs for S100A8

    Protein Domains /
    Families
    for S100A8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    S100A8 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR013787 S100_Ca-bd_sub
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry P05109

    ProtoNet protein and cluster: P05109

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Function
    for S100A8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
    Function: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory
    processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin
    (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include:
    facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton
    during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by
    facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to
    the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The
    extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.
    Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and
    regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP)
    molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4
    (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and
    NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial
    activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is
    essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the
    cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can
    regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4
    and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing
    exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as
    well as in cancer development and tumor spread

         Genatlas biochemistry entry for S100A8:
    S100 calcium binding protein A8,calgranulin A,epidermal differentiation complex

    miRNA
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    hsa-mir-451 (MIRT000046)

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    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-miR-1205 hsa-let-7g hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS--
    GO:0005515protein binding IPI--
    GO:0008017microtubule binding TAS--
    GO:0008270zinc ion binding TAS--
    GO:0035662Toll-like receptor 4 binding TAS--


    S100A8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for S100A8:
     Increased G2M DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-outs for S100A8: S100a8tm1Hume S100a8tm1Hogg
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for S100a8):
     embryogenesis  mortality/aging 

    S100A8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for S100A8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of C/EBPbeta
    		Selected targets of C/EBPbeta1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for S100A8
        Selected targets of C/EBPbeta




    S100A8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for S100A8 (P051091, 2, 3 ENSP000003577214) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-63391 I2D: score=5 STRING: ENSP00000269305
    C14orf1Q9UKR52, 3MINT-63401 I2D: score=5 
    CHGBP050602, 3MINT-63392 I2D: score=5 
    GDF9O603832, 3MINT-63390 I2D: score=5 
    PDCD11Q146902, 3MINT-63394 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production TAS--
    GO:0002523leukocyte migration involved in inflammatory response IDA12626582
    GO:0002526acute inflammatory response IEA--
    GO:0002544chronic inflammatory response IEA--
    GO:0006914autophagy IDA19935772


    S100A8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for S100A8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100A8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for S100A8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTZO 1MIF binder[99420-15-2]

    1 HMDB Compound for S100A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/51 Novoseek chemical compound relationships for S100A8 gene (see all 51)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clarithromycin 59.5 15 17205045 (3), 11326028 (2), 11302817 (1), 12385434 (1) (see all 10)
    atpa 51.6 1 12748272 (1)
    amoxicillin 42.9 7 12425876 (2), 10378418 (1), 12385434 (1), 10855013 (1) (see all 5)
    scca1 42.1 1 17638865 (1)
    metronidazole 39.6 7 19604178 (2), 10378418 (1), 16038520 (1), 11390701 (1) (see all 5)
    tyrosine 32.4 123 12752736 (9), 11929545 (5), 12925139 (5), 11777849 (4) (see all 43)
    urea 25.2 7 9746590 (1), 15377296 (1), 18334875 (1), 10340709 (1) (see all 6)
    omeprazole 23.9 2 12385434 (1), 12425876 (1)
    tazarotene 23.4 1 9325272 (1)
    monosodium urate 17.9 2 12905486 (2)

    Search CenterWatch for drugs/clinical trials and news about S100A8 / S10A8 

    Transcripts
    for S100A8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for S100A8 gene: 
    NM_002964.4  

    Unigene Cluster for S100A8:

    S100 calcium binding protein A8
    Hs.416073  [show with all ESTs]
    Unigene Representative Sequence: BG739729
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368733(uc001fbs.3) ENST00000368732 ENST00000477801

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    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-miR-1205 hsa-let-7g hsa-let-7e
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    Clone
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    Additional cDNA sequence: 

    AK291328.1 BC005928.2 BT007378.1 CR407674.1 X06234.1 Y00278.1 

    20 DOTS entries:

    DT.97864015  DT.91911261  DT.91765796  DT.100877161  DT.95110289  DT.100877152  DT.95351910  DT.100877151 
    DT.100877153  DT.100877155  DT.91765792  DT.121432975  DT.121432976  DT.91738911  DT.95351901  DT.75189937 
    DT.91892881  DT.91965391  DT.95325317  DT.95375948 

    24/431 AceView cDNA sequences (see all 431):

    AW025222 AA321026 F25314 AW268644 BM955347 BM955362 BM955376 AJ706285 
    AI952048 T99218 AW628258 AJ713934 AW265329 NM_002964 AA321357 CA487402 
    BM955365 AA716239 AJ705422 BM955353 BM955381 AJ705424 AW468109 F33754 

    GeneLoc Exon Structure


    Expression
    for S100A8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCTGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    S100A8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See S100A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100A8

    SOURCE GeneReport for Unigene cluster: Hs.416073

    UniProtKB/Swiss-Prot: S10A8_HUMAN, P05109
    Tissue specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory
    conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are
    expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under
    chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in
    high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as
    rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis,
    Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and
    deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many
    tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including S100A8 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

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    Orthologs
    for S100A8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for S100A8 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia S100a81 , 5 S100 calcium binding protein A8 (calgranulin A)1, 5 70.79(n)1
    58.43(a)1    		   3 (39.90 cM)5
    202011  NM_013650.21  NP_038678.11 
     906690715 


    ENSEMBL Gene Tree for S100A8 (if available)
    TreeFam Gene Tree for S100A8 (if available) 

    Paralogs
    for S100A8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S100A8 gene
    S100A112  S100A62  S100A12  S100A122  S100A42  S100B2  S100A32  S100A102  
    S100Z2  S100A52  S100P2  S100A22  S100A92  
    18/22 SIMAP similar genes for S100A8 using alignment to 1 protein entry:     S10A8_HUMAN(see all similar genes):
    S100B    HRNR    RPTN    S100G    FLG    S100A5
    S100P    S100A1    S100A11    S100A4    S100A9    S100A13
    TCHH    S100A10    S100A12    S100A6    FLG2    S100A2

    S100A8 for paralogs           About GeneDecksing



    Genomic Variants
    for S100A8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/74 NCBI SNPs in S100A8 are shown (see all 74)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs604738301,2
    		C,--153362105(+) CACAGG/ACACAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1420183391,2
    		C,--153362105(+) CACAG-/ACACACA 1 -- ds50010--------
    rs66591041,2
    		C,F,A,H,--153362146(+) ATCACT/CCTAAT 1 -- ds500124Minor allele frequency- C:0.18NA NS EA WA CSA 2452
    rs1862393871,2
    		--153362189(+) GAAGCC/TAAAAT 1 -- ds50010--------
    rs1901549491,2
    		--153362220(+) AGTTGC/TTCTTA 1 -- ds50010--------
    rs75457281,2
    		C,F,H,--153362251(+) ATCCCC/TGACCC 1 -- ds50018Minor allele frequency- T:0.01NS EA NA WA 922
    rs1821401511,2
    		--153362293(+) TAGTGG/TCATGG 1 -- ds50010--------
    rs1381771541,2
    		--153362301(+) TGGACG/TTTTTG 1 -- ds50010--------
    rs592016461,2
    		C,--153362423(+) ATAACA/TTAGAT 1 -- ds50012Minor allele frequency- T:0.03WA 120
    rs1867445901,2
    		--153362446(+) CTTTGG/TGTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for S100A8 (153362508 - 153363664 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for S100A8: --

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    Disorders / Diseases
    for S100A8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    S100A8 for disorders           About GeneDecksing

    OMIM gene information: 123885    OMIM disorders: --

    20/131 diseases for S100A8 (see all 131):    About MalaCards
    cystic fibrosis    fibrosis    mixed connective tissue disease    connective tissue disease
    middle ear cholesteatoma    diffuse large b-cell lymphoma    gastroesophageal reflux disease    peptic ulcer
    relapsing polychondritis    b-cell lymphomas    barrett's esophagus    duodenal ulcer
    traumatic brain injury    malt lymphoma    non-hodgkin lymphoma    gastritis
    food allergy    duodenitis    cholesteatoma    inflammatory bowel disease

    2 diseases from the University of Copenhagen DISEASES database for S100A8:
    Arthritis     Psoriasis

    10/94 Novoseek disease relationships for S100A8 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastritis 91.6 174 9398887 (5), 17890898 (4), 8586721 (3), 16302986 (3) (see all 99)
    peptic ulcer 89.5 159 10861258 (5), 10823130 (5), 9619383 (4), 9759946 (4) (see all 86)
    duodenal ulcer 88.7 90 10548360 (3), 16543737 (3), 19710266 (3), 9398887 (3) (see all 56)
    gastritis chronic 88 53 20136573 (4), 12640706 (3), 10823130 (3), 11780331 (3) (see all 31)
    gastric cancer 83.8 166 14724815 (8), 19685530 (5), 9659265 (4), 15300891 (3) (see all 91)
    gastric ulcer 81.9 43 11158115 (3), 7650174 (2), 11519793 (2), 12645789 (2) (see all 25)
    adenocarcinoma gastric 79 42 12752736 (5), 10189841 (4), 9286230 (2), 11427555 (2) (see all 20)
    duodenal ulcer disease 77.8 19 12697114 (2), 11843964 (2), 11158115 (2), 12734242 (1) (see all 9)
    gastritis atrophic 75.8 20 17760724 (3), 12925139 (2), 10364597 (1), 9146793 (1) (see all 13)
    metaplasia 72.3 25 11288377 (3), 9691913 (2), 9517643 (2), 12663641 (2) (see all 19)

    Human Genome Epidemiology (HuGE) Navigator: S100A8 (5 documents)

    Export disorders for S100A8 gene to outside databases

    Publications
    for S100A8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100A8 gene, integrated from 9 sources (see all 821):
    (articles sorted by number of sources associating them with S100A8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. (PubMed id 1326551)1, 2, 9 Lemarchand P.... Markert M. (1992)
    2. Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. (PubMed id 19087201)1, 2, 9 Sroussi H.Y....Palefsky J.M. (2009)
    3. Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PubMed id 8619876)1, 2, 9 Marti T.... Gallin M.Y. (1996)
    4. The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells. (PubMed id 2039599)1, 2, 9 Schaefer T.... Gassen H.G. (1991)
    5. S100A8 and S100A9: new insights into their roles in ma lignancy. (PubMed id 21912088)1, 2 Srikrishna G. (2012)
    6. Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway. (PubMed id 22363402)1, 2 Atallah M....Mevorach D. (2012)
    7. S100A8/A9 induces autophagy and apoptosis via ROS-med iated cross-talk between mitochondria and lysosomes that involves BNIP3. (PubMed id 19935772)1, 2 Ghavami S....Los M. (2010)
    8. Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9. (PubMed id 18786929)1, 2 Bode G....Nacken W. (2008)
    9. S-nitrosylated S100A8: novel anti-inflammatory properties. (PubMed id 18832721)1, 2 Lim S.Y....Geczy C.L. (2008)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)

    External Searches for S100A8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing S100A8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6279 HGNC: 10498 AceView: S100A8 Ensembl:ENSG00000143546 euGenes: HUgn6279
    ECgene: S100A8 H-InvDB: S100A8

    Other Databases showing S100A8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing S100A8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100A8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for S100A8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for S100A8 gene:
    Search GeneIP for patents involving S100A8

    GeneCards and IP:
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