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S100A7A Gene

protein-coding GIFtS: 43

GC01P151655

S100 calcium binding protein A7A
(Previous names: S100 calcium binding protein A15, S100 calcium binding protein A7-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: S100A15, S100A7L1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NICE-2 ^²
OTTHUMP00000015324 ^²
OTTHUMP00000015325 ^²
OTTHUMP00000015326 ^²
S100A15 ^², ³
S100A7L1 ^², ³
S100A7f ^¹, ²

Descriptions
S100 calcium binding protein A15 ^¹, ²
S100 calcium binding protein A7-like 1 ^¹, ²
S100 calcium binding protein A7A ^²
S100 calcium-binding protein A15 ^³
S100 calcium-binding protein A7-like 1 ^³
S100 calcium-binding protein A7A ^³

External Ids
HGNC: 21657¹
Entrez Gene: 338324²
UniProtKB: Q86SG5³
Ensembl: ENSG00000184330⁷

Search outside databases for aliases for S100A7A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Function: May be involved in epidermal differentiation and inflammation and might therefore be

important for the pathogenesis of psoriasis and other diseases

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q22

S100A7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P151655: (about GC identifiers)

Start:	151,655,624 bp from pter
End:	151,662,325 bp from pter
Size:	6,702 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5 (See protein sequence)

Recommended Name: Protein S100-A7A

Size: 101 amino acids; 11305 Da

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: Q5SY69

REFSEQ proteins: NP_789793.1

ENSEMBL proteins:

ENSP00000357718 ENSP00000357717 ENSP00000329008

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for S100A7A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for S100A7A

Assays for S100A7A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86SG5

ProtoNet protein and cluster: Q86SG5

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A7A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A7L1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_176823

Applied Biosystems Silencer® siRNAs for S100A7A

Sigma-Aldrich siRNA for S100A7A

Sigma-Aldrich shRNA for S100A7A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100A7A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_176823
Myc/DDK tagged cDNA clone in CMV expression vector: NM_176823
untagged cDNA clone in CMV expression vector: NM_176823

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_176823

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Function: May be involved in epidermal differentiation and inflammation and might therefore be

important for the pathogenesis of psoriasis and other diseases

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for S100A7A (ENSP00000357718³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HRAS	ENSP00000373382³	STRING (score=.733)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A7A
1 Novoseek chemical compound relationship for S100A7A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	19.52	3	17620096 (2), 16528363 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A7A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A7L1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_176823

Sigma-Aldrich siRNA for S100A7A

Sigma-Aldrich shRNA for S100A7A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_176823

REFSEQ mRNAs for S100A7A gene:

NM_176823.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_176823

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_176823
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_176823
                                 untagged cDNA clone in CMV expression vector: NM_176823

Additional cDNA sequence:

AJ243672.2 AJ243673.1 AY189118.1 AY189119.1 BC040254.1

2 DOTS entries:

DT.91670968 DT.111095

1 AceView cDNA sequence:

AW176058

highest scoring ESTs for S100A7A:

AJ243672 AJ243673 AW176058 AY189118 AY189119 BC040254 BE140620 BE182957 BG680046 BG743277

Unigene Cluster for S100A7A:

S100 calcium binding protein A7A

Hs.442337 [show with all ESTs]

Unigene Representative Sequence: AY189118

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000368729 ENST00000368728 ENST00000329256

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A7A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100A7A

¹ / ² / ³

4 probe-sets matching S100A7A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
232170_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AJ243672	0.80	1.00	0.91	1
205916_at²	U133-A	2	0.82	0.41	--	--	--	--	--	--	--
232170_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205916_at²	U133Plus2	2	0.82	0.41	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCCCTTATA

SOURCE GeneReport for Unigene cluster: Hs.442337
UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5
Tissue specificity: Overexpressed in psoriasis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100A7A gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	S100A7A¹	--	S100 calcium binding protein A7A	97.69(n) 95.05(a)	469499 XM_524882.2 XP_524882.2
mouse (Mus musculus)	S100a7a⁵	3	S100 calcium binding protein A7A	--	BC107308

About this table Species with no ortholog for S100A7A

ENSEMBL Gene Tree for S100A7A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S100A7A gene

S100A7² S100A7L2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/58 NCBI SNPs in S100A7A are shown (see all 58 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 19)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3006412^1,2	A,C,F,H	151657166(+)	`TGAAGG/CCTTTT`	1	--	ut5¹ ese³		4		EU EA WA	418
	rs3006417^1,2	A,C,F,H	151662008(+)	`TATAAA/CAACAC`	1	--	ut3¹		7		EU EA WA NA	560
	rs3014818^1,2	C,F,H	151660178(+)	`CTTGCT/CGCTGT`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs7411969^1,2	A,H	151655201(+)	`TAAAAC/TGCTCA`	1	--	ng5¹		4		EU EA WA	412
--	rs3014814^1,2	F,H	151658668(+)	`TGCACC/GGTTCC`	1	--	ut3¹		4		EU EA WA	408
--	rs3006414^1,2	F,H	151658353(+)	`TAGCCG/ACAGAC`	1	T/A	mis¹ ese³		4		EU EA WA	418
--	rs3014819^1,2	A,C	151662730(+)	`TTGGAA/GTATAT`	1	--	ng3¹		0	--	--	--	--
--	rs3014812^1,2	A,C	151655505(+)	`CCCACA/CCACCT`	1	--	ng5¹		0	--	--	--	--
--	rs3014817^1,2	A	151659942(+)	`TGCCCC/TCCATC`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs3014815^1,2	A	151659617(+)	`CATCCC/TACCAG`	1	--	ut3¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for S100A7A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

1 Novoseek disease relationship for S100A7A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis	68.55	3	16682778 (2), 17620096 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/12 PubMed articles for S100A7A gene (see all 12 ):

Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PubMed id 12664160)^{1, 3, 4} Kulski J.K.... Bellgard M. (2003)
Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. (PubMed id 12923069)^{1, 3, 4} Wolf R.... Ruzicka T. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)^{2, 3} Marenholz I....Mischke D. (2001)
Purification, crystallization and preliminary X-ray diffraction of human S100A15. (PubMed id 16682778)^{1, 3} Boeshans K.M....Ahvazi B. (2006)
Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (PubMed id 17620096)^{1, 3} Wolf R....Ruzicka T. (2007)
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. (PubMed id 18606705)³ Wolf R....Yuspa S.H. (2008)
S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. (PubMed id 17625598)³ Buchau A.S....Ruzicka T. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. (PubMed id 1940442)³ Madsen P.... Celis J.E. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 338324	HGNC: 21657	AceView: S100A7L1.2	Ensembl:ENSG00000184330	euGenes: HUgn338324
ECgene: S100A7A	H-InvDB: S100A7A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for S100A7A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S100A7A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100A7A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100A7A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S100A7A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for S100A7A

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Search Novus for antibodies for S100A7A

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S100A7A Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for S100A7A

Summaries
for S100A7A

Genomic Location
for S100A7A

Proteins
for S100A7A

Protein Domains/
Families
for S100A7A

Gene Function
for S100A7A

Pathways & Interactions
for S100A7A

Drugs & Compounds
for S100A7A

Transcripts
for S100A7A

Expression
for S100A7A

Orthologs
for S100A7A

Paralogs
for S100A7A

SNPs/Variants
for S100A7A

Disorders & Mutations
for S100A7A

Medical News
for S100A7A

Publications
for S100A7A

Search for S100A7A

Genome Databases showing S100A7A

Other Databases showing S100A7A

Specialized Databases showing S100A7A

Licensable Technologies
for S100A7A

Services
for S100A7A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100A7A Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor S100A7A

Summariesfor S100A7A

Genomic Locationfor S100A7A

Proteinsfor S100A7A

Protein Domains/Familiesfor S100A7A

Gene Functionfor S100A7A

Pathways & Interactionsfor S100A7A

Drugs & Compoundsfor S100A7A

Transcriptsfor S100A7A

Expression for S100A7A

Orthologsfor S100A7A

Paralogsfor S100A7A

SNPs/Variantsfor S100A7A

Disorders & Mutationsfor S100A7A

Medical Newsfor S100A7A

Publicationsfor S100A7A

Search for S100A7A

Genome Databases showing S100A7A

Other Databases showing S100A7A

Specialized Databases showing S100A7A

Licensable Technologiesfor S100A7A

Servicesfor S100A7A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100A7A

Summaries
for S100A7A

Genomic Location
for S100A7A

Proteins
for S100A7A

Protein Domains/
Families
for S100A7A

Gene Function
for S100A7A

Pathways & Interactions
for S100A7A

Drugs & Compounds
for S100A7A

Transcripts
for S100A7A

Expression
for S100A7A

Orthologs
for S100A7A

Paralogs
for S100A7A

SNPs/Variants
for S100A7A

Disorders & Mutations
for S100A7A

Medical News
for S100A7A

Publications
for S100A7A

Licensable Technologies
for S100A7A

Services
for S100A7A