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Aliases for S100A7A Gene

Aliases for S100A7A Gene

  • S100 Calcium Binding Protein A7A 2 3 5
  • S100 Calcium-Binding Protein A7-Like 1 3 4
  • S100 Calcium-Binding Protein A15 3 4
  • S100A7L1 3 4
  • S100A15 3 4
  • S100 Calcium Binding Protein A7-Like 1 2
  • S100 Calcium Binding Protein A15 2
  • S100 Calcium-Binding Protein A7A 4
  • Protein S100-A7A 3
  • S100A7f 3
  • NICE-2 3

External Ids for S100A7A Gene

Previous HGNC Symbols for S100A7A Gene

  • S100A15
  • S100A7L1

Previous GeneCards Identifiers for S100A7A Gene

  • GC01P151655
  • GC01P124752

Summaries for S100A7A Gene

GeneCards Summary for S100A7A Gene

S100A7A (S100 Calcium Binding Protein A7A) is a Protein Coding gene. Diseases associated with S100A7A include Psoriasis. Among its related pathways are Immune System. GO annotations related to this gene include calcium ion binding and protein self-association. An important paralog of this gene is S100A7.

UniProtKB/Swiss-Prot for S100A7A Gene

  • May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Gene Wiki entry for S100A7A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A7A Gene

Genomics for S100A7A Gene

Regulatory Elements for S100A7A Gene

Enhancers for S100A7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F153606 1.1 FANTOM5 ENCODE 1.3 +195.9 195936 11.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS S100A1 SNAPIN ILF2 ENSG00000233222 ENSG00000243613 INTS3 S100A16 S100A13 ENSG00000272030 S100A14
GH01F153404 1 Ensembl ENCODE 0.4 -11.6 -11576 0.5 CTCF CBX3 USF1 CREB3L1 MAX RAD21 SCRT2 SMC3 CREM E2F6 PGLYRP4 S100A9 RNU6-160P CHTOP ENSG00000224784 S100A7A
GH01F153402 0.5 Ensembl 0.4 -12.8 -12824 1.8 RNF2 L3MBTL2 CREB3L1 MIER1 CEBPG DPF2 TFDP1 GATA3 HDAC2 FOS PGLYRP4 S100A9 RNU6-160P S100A12 CHTOP ENSG00000224784 S100A7A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around S100A7A on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A7A Gene

153,416,524 bp from pter
153,423,225 bp from pter
6,702 bases
Plus strand

Genomic View for S100A7A Gene

Genes around S100A7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A7A Gene

Proteins for S100A7A Gene

  • Protein details for S100A7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A7A
    Protein Accession:
    Secondary Accessions:
    • D3DV38
    • Q5SY69

    Protein attributes for S100A7A Gene

    101 amino acids
    Molecular mass:
    11305 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S100A7A Gene

neXtProt entry for S100A7A Gene

Post-translational modifications for S100A7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A7A Gene

Domains & Families for S100A7A Gene

Suggested Antigen Peptide Sequences for S100A7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A7A: view

Function for S100A7A Gene

Molecular function for S100A7A Gene

UniProtKB/Swiss-Prot Function:
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Gene Ontology (GO) - Molecular Function for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0043621 protein self-association IDA 21148126
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A7A: view
genes like me logo Genes that share phenotypes with S100A7A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A7A Gene

Localization for S100A7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A7A Gene


Subcellular locations from

Jensen Localization Image for S100A7A Gene COMPARTMENTS Subcellular localization image for S100A7A gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with S100A7A: view

Pathways & Interactions for S100A7A Gene

SuperPathways for S100A7A Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with S100A7A: view

Pathways by source for S100A7A Gene

2 Reactome pathways for S100A7A Gene

Interacting Proteins for S100A7A Gene

Selected Interacting proteins: Q86SG5-S1A7A_HUMAN for S100A7A Gene via IID

Gene Ontology (GO) - Biological Process for S100A7A Gene


No data available for SIGNOR curated interactions for S100A7A Gene

Drugs & Compounds for S100A7A Gene

(1) Drugs for S100A7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with S100A7A: view

Transcripts for S100A7A Gene

mRNA/cDNA for S100A7A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A7A Gene

S100 calcium binding protein A7A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A7A Gene

No ASD Table

Relevant External Links for S100A7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A7A Gene

mRNA differential expression in normal tissues according to GTEx for S100A7A Gene

This gene is overexpressed in Esophagus - Mucosa (x38.1) and Minor Salivary Gland (x4.7).

Protein differential expression in normal tissues from HIPED for S100A7A Gene

This gene is overexpressed in Oral epithelium (35.2), Heart (12.1), Saliva (8.1), and Urine (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S100A7A Gene

Protein tissue co-expression partners for S100A7A Gene

NURSA nuclear receptor signaling pathways regulating expression of S100A7A Gene:


SOURCE GeneReport for Unigene cluster for S100A7A Gene:


mRNA Expression by UniProt/SwissProt for S100A7A Gene:

Tissue specificity: Overexpressed in psoriasis.
genes like me logo Genes that share expression patterns with S100A7A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for S100A7A Gene

Orthologs for S100A7A Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A7A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A7A 35
  • 95 (a)
(Bos Taurus)
Mammalia -- 35
  • 66 (a)
S100A7 35
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
(Mus musculus)
Mammalia S100a7a 35
  • 31 (a)
(Canis familiaris)
Mammalia -- 35
  • 29 (a)
Species where no ortholog for S100A7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A7A Gene

Gene Tree for S100A7A (if available)
Gene Tree for S100A7A (if available)

Paralogs for S100A7A Gene

Paralogs for S100A7A Gene

(12) SIMAP similar genes for S100A7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A7A: view

Variants for S100A7A Gene

Sequence variations from dbSNP and Humsavar for S100A7A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111227925 -- 153,416,102(+) AAAAC(A/G)CTCAG intron-variant, upstream-variant-2KB
rs111506830 -- 153,417,728(+) TCCGC(A/C)ATGTG intron-variant
rs111640949 -- 153,418,347(+) AAATA(A/G)GGCTT intron-variant
rs112079077 -- 153,418,071(+) GCTTT(G/T)TGAAA intron-variant, utr-variant-5-prime
rs112079848 -- 153,419,246(+) GGAGA(C/T)ATAGC intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for S100A7A Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958
nsv946398 CNV duplication 23825009
nsv952211 CNV deletion 24416366

Variation tolerance for S100A7A Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A7A Gene

Disorders for S100A7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100A7A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A7A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with S100A7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A7A Gene

Publications for S100A7A Gene

  1. Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PMID: 12664160) Kulski J.K. … Bellgard M. (J. Mol. Evol. 2003) 3 4 22 64
  2. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. (PMID: 12923069) Wolf R. … Ruzicka T. (FASEB J. 2003) 3 4 22 64
  3. Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding. (PMID: 22747601) Murray J.I. … Boulanger M.J. (BMC Struct. Biol. 2012) 3 4 64
  4. Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (PMID: 17620096) Wolf R. … Ruzicka T. (Exp. Dermatol. 2007) 3 22 64
  5. Purification, crystallization and preliminary X-ray diffraction of human S100A15. (PMID: 16682778) Boeshans K.M. … Ahvazi B. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 22 64

Products for S100A7A Gene

Sources for S100A7A Gene

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