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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

S100A7A Gene

protein-coding GIFtS: 47
GCID: GC01P153392

S100 calcium binding protein A7A

(Previous names: S100 calcium binding protein A15, S100 calcium binding...)
(Previous symbols: S100A15, S100A7L1)

Explore 2 diseases affiliated with
S100A7A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
S100 Calcium Binding Protein A7A¹ ²		S100 Calcium-Binding Protein A15² ³
S100A15¹ ² ³		S100 Calcium-Binding Protein A7-Like 1² ³
S100A7L1¹ ² ³		S100 Calcium-Binding Protein A7A² ³
S100A7f¹ ²		NICE-2²
S100 Calcium Binding Protein A15¹ ²		Protein S100-A7A²
S100 Calcium Binding Protein A7-Like 1¹ ²

External Ids:	HGNC: 21657¹	Entrez Gene: 338324²	Ensembl: ENSG00000184330⁷	UniProtKB: Q86SG5³

Export aliases for S100A7A gene to outside databases

Previous GC identifers: GC01P151655 GC01P124752

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Function: May be involved in epidermal differentiation and inflammation and might therefore be important for the

pathogenesis of psoriasis and other diseases

Gene Wiki entry for S100A7A (S100A15)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the S100A7A gene promoter:
COUP-TF1 LHX3b/Lhx3b COUP HNF-4alpha2 C/EBPalpha HNF-4alpha1 COUP-TF HOXA5 Chx10 LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100A7A promoter sequence

Search SABiosciences Chromatin IP Primers for S100A7A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A7A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q22

S100A7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A7A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P153392: view genomic region (about GC identifiers)

Start:	153,388,945 bp from pter	End:	153,395,701 bp from pter
Size:	6,757 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5 (See protein sequence)

Recommended Name: Protein S100-A7A

Size: 101 amino acids; 11305 Da

Subcellular location: Cytoplasm (By similarity)

1 PDB 3D structure from and Proteopedia for S100A7A:

4AQI (3D)

Secondary accessions: D3DV38 Q5SY69

Explore the universe of human proteins at neXtProt for S100A7A: NX_Q86SG5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86SG5

S100A7A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_789793.1

ENSEMBL proteins:

ENSP00000357718 ENSP00000357717 ENSP00000329008

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

S100A7A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

S100A7A for domains About GeneDecksing

5 InterPro domains/families:

IPR018247 EF_Hand_1_Ca_BS

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR013787 S100_Ca-bd_sub

IPR001751 S100/CaBP-9k_CS

Graphical View of Domain Structure for InterPro Entry Q86SG5

ProtoNet protein and cluster: Q86SG5

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Function: May be involved in epidermal differentiation and inflammation and might therefore be important for the

pathogenesis of psoriasis and other diseases

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

S100A7A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for S100A7A:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for S100A7A

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for S100A7A (ENSP00000329008⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPS5	ENSP00000350512⁴	STRING: ENSP00000350512
FABP5	ENSP00000297258⁴	STRING: ENSP00000297258

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

S100A7A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for S100A7A
1 Novoseek chemical compound relationship for S100A7A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	18.9	3	17620096 (2), 16528363 (1)

Search CenterWatch for drugs/clinical trials and news about S100A7A / S1A7A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for S100A7A gene:

NM_176823.3

Unigene Cluster for S100A7A:

S100 calcium binding protein A7A

Hs.442337 [show with all ESTs]

Unigene Representative Sequence: AY189118

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368729(uc001fbt.1) ENST00000368728 ENST00000329256

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Additional cDNA sequence:

AJ243672.2 AJ243673.1 AY189118.1 AY189119.1 BC040254.1

2 DOTS entries:

DT.91670968 DT.111095

1 AceView cDNA sequence:

AW176058

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

S100A7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCCTTATA

About this image

S100A7A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See S100A7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100A7A

SOURCE GeneReport for Unigene cluster: Hs.442337

UniProtKB/Swiss-Prot: S1A7A_HUMAN, Q86SG5

Tissue specificity: Overexpressed in psoriasis

SABiosciences Expression via Pathway-Focused PCR Arrays including S100A7A:

Necrosis in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Cell Death PathwayFinder in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A7A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for S100A7A (if available)
TreeFam Gene Tree for S100A7A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for S100A7A gene

S100A7² S100A7L2²

12 SIMAP similar genes for S100A7A using alignment to 1 protein entry: S1A7A_HUMAN:

S100A7 S100A7L2 S100A4 S100B S100A6 S100Z

S100A7L3 S100P S100A12 S100A10 S100A11 S100A8

S100A7A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142900588^1,2		--	153387028(+)	`AAACAA/TCAATG`	1	--	us2k¹		0	--	--	--	--
rs146273173^1,2		--	153387032(+)	`AACAAC/TGAGAT`	1	--	us2k¹		0	--	--	--	--
rs188452196^1,2		--	153387176(+)	`CAGTTC/TGGTGC`	1	--	us2k¹		0	--	--	--	--
rs139031476^1,2		--	153387196(+)	`AAACTA/GAACAT`	1	--	us2k¹		0	--	--	--	--
rs143042015^1,2		--	153387236(+)	`TCTTCA/GGGATT`	1	--	us2k¹		0	--	--	--	--
rs11579041^1,2	C,F,H,	--	153387260(+)	`TGAAAG/ACTTAT`	1	--	us2k¹		8		NA WA CSA EA	370
rs80061196^1,2	F,	--	153387297(+)	`GTATAT/AGAACA`	1	--	us2k¹		1		NA	120
rs181443885^1,2		--	153387315(+)	`CAGTGG/TTGAAG`	1	--	us2k¹		0	--	--	--	--
rs144724008^1,2		--	153387324(+)	`AGTCCA/GGGCTT`	1	--	us2k¹		0	--	--	--	--
rs186035278^1,2		--	153387355(+)	`AACACA/GCATTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for S100A7A (153388945 - 153395701 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for S100A7A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

S100A7A for disorders About GeneDecksing

2 diseases for S100A7A: About MalaCards

psoriasis skin disease

1 Novoseek disease relationship for S100A7A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis	67.6	3	16682778 (2), 17620096 (1)

Export disorders for S100A7A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for S100A7A gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with S100A7A)

Utopia: connect your pdf to the dynamic
world of online information

Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PubMed id 12664160)^{1, 2, 9} Kulski J.K.... Bellgard M. (2003)
Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. (PubMed id 12923069)^{1, 2, 9} Wolf R.... Ruzicka T. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)^{1, 3} Marenholz I....Mischke D. (2001)
Purification, crystallization and preliminary X-ray diffraction of human S100A15. (PubMed id 16682778)^{1, 9} Boeshans K.M....Ahvazi B. (2006)
Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (PubMed id 17620096)^{1, 9} Wolf R....Ruzicka T. (2007)
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. (PubMed id 18606705)¹ Wolf R....Yuspa S.H. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. (PubMed id 17625598)¹ Buchau A.S....Ruzicka T. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 338324	HGNC: 21657	AceView: S100A7L1.2	Ensembl:ENSG00000184330	euGenes: HUgn338324
ECgene: S100A7A	H-InvDB: S100A7A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for S100A7A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for S100A7A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for S100A7A gene:
Search GeneIP for patents involving S100A7A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A7A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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S100A7A Gene

S100 calcium binding protein A7A

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S100A7A Gene

S100 calcium binding protein A7A

Aliasesfor S100A7A gene

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