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Aliases for S100A7A Gene

Aliases for S100A7A Gene

  • S100 Calcium Binding Protein A7A 2 3
  • S100 Calcium Binding Protein A7-Like 1 2 3
  • S100 Calcium-Binding Protein A7-Like 1 3 4
  • S100 Calcium Binding Protein A15 2 3
  • S100 Calcium-Binding Protein A15 3 4
  • S100 Calcium-Binding Protein A7A 3 4
  • S100A7L1 3 4
  • S100A15 3 4
  • Protein S100-A7A 3
  • S100A7f 3
  • NICE-2 3

External Ids for S100A7A Gene

Previous Symbols for S100A7A Gene

  • S100A15
  • S100A7L1

Summaries for S100A7A Gene

GeneCards Summary for S100A7A Gene

S100A7A (S100 Calcium Binding Protein A7A) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A7L2.

UniProtKB/Swiss-Prot for S100A7A Gene

  • May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases

Gene Wiki entry for S100A7A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A7A Gene

Genomics for S100A7A Gene

Genomic Location for S100A7A Gene

Start:
153,416,524 bp from pter
End:
153,423,225 bp from pter
Size:
6,702 bases
Orientation:
Plus strand

Genomic View for S100A7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A7A Gene

Regulatory Elements for S100A7A Gene

Proteins for S100A7A Gene

  • Protein details for S100A7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SG5-S1A7A_HUMAN
    Recommended name:
    Protein S100-A7A
    Protein Accession:
    Q86SG5
    Secondary Accessions:
    • D3DV38
    • Q5SY69

    Protein attributes for S100A7A Gene

    Size:
    101 amino acids
    Molecular mass:
    11305 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S100A7A Gene

neXtProt entry for S100A7A Gene

Proteomics data for S100A7A Gene at MOPED

Post-translational modifications for S100A7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A7A Gene

Domains for S100A7A Gene

Gene Families for S100A7A Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

UniProtKB/Swiss-Prot:

S1A7A_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • Q86SG5
Family:
  • Belongs to the S-100 family.:
    • Q86SG5
genes like me logo Genes that share domains with S100A7A: view

Function for S100A7A Gene

Molecular function for S100A7A Gene

UniProtKB/Swiss-Prot Function: May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases

Gene Ontology (GO) - Molecular Function for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0043621 protein self-association IDA 21148126
genes like me logo Genes that share ontologies with S100A7A: view

Phenotypes for S100A7A Gene

GenomeRNAi human phenotypes for S100A7A:
genes like me logo Genes that share phenotypes with S100A7A: view

miRNA for S100A7A Gene

miRTarBase miRNAs that target S100A7A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for S100A7A Gene

Localization for S100A7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A7A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A7A Gene COMPARTMENTS Subcellular localization image for S100A7A gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with S100A7A: view

Pathways for S100A7A Gene

SuperPathways for S100A7A Gene

No Data Available

Interacting Proteins for S100A7A Gene

Gene Ontology (GO) - Biological Process for S100A7A Gene

None

No data available for Pathways by source for S100A7A Gene

Compounds for S100A7A Gene

(1) Novoseek inferred chemical compound relationships for S100A7A Gene

Compound -log(P) Hits PubMed IDs
calcium 18.9 3
genes like me logo Genes that share compounds with S100A7A: view

Transcripts for S100A7A Gene

mRNA/cDNA for S100A7A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A7A Gene

S100 calcium binding protein A7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A7A Gene

No ASD Table

Relevant External Links for S100A7A Gene

GeneLoc Exon Structure for
S100A7A
ECgene alternative splicing isoforms for
S100A7A

Expression for S100A7A Gene

mRNA expression in normal human tissues for S100A7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A7A Gene

This gene is overexpressed in Esophagus - Mucosa (38.1) and Minor Salivary Gland (4.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for S100A7A Gene

SOURCE GeneReport for Unigene cluster for S100A7A Gene Hs.442337

mRNA Expression by UniProt/SwissProt for S100A7A Gene

Q86SG5-S1A7A_HUMAN
Tissue specificity: Overexpressed in psoriasis
genes like me logo Genes that share expressions with S100A7A: view

Orthologs for S100A7A Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A7A 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 66 (a)
ManyToMany
S100A7 37
  • 63 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 29 (a)
OneToMany
mouse
(Mus musculus)
Mammalia S100a7a 16
S100a7a 37
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 31 (a)
OneToMany
Species with no ortholog for S100A7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A7A Gene

ENSEMBL:
Gene Tree for S100A7A (if available)
TreeFam:
Gene Tree for S100A7A (if available)

Paralogs for S100A7A Gene

Paralogs for S100A7A Gene

Selected SIMAP similar genes for S100A7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A7A: view

Variants for S100A7A Gene

Sequence variations from dbSNP and Humsavar for S100A7A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3006412 -- 153,418,066(+) TGAAG(C/G)CTTTT utr-variant-5-prime
rs3006413 -- 153,418,920(+) GACCT(C/G)CCTCC intron-variant
rs3006414 - 153,419,253(+) TAGCC(A/G)CAGAC missense, reference
rs3006415 -- 153,419,566(+) TCTGC(A/C)CCGTT utr-variant-3-prime, intron-variant
rs3006416 -- 153,419,826(+) CCTTG(G/T)GGCTA utr-variant-3-prime, intron-variant

Relevant External Links for S100A7A Gene

HapMap Linkage Disequilibrium report
S100A7A

No data available for Structural Variations from Database of Genomic Variants (DGV) for S100A7A Gene

Disorders for S100A7A Gene

(1) Novoseek inferred disease relationships for S100A7A Gene

Disease -log(P) Hits PubMed IDs
psoriasis 67.6 3
genes like me logo Genes that share disorders with S100A7A: view

No data available for UniProtKB/Swiss-Prot for S100A7A Gene

Publications for S100A7A Gene

  1. Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PMID: 12664160) Kulski J.K. … Bellgard M. (J. Mol. Evol. 2003) 3 4 23
  2. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. (PMID: 12923069) Wolf R. … Ruzicka T. (FASEB J. 2003) 3 4 23
  3. Purification, crystallization and preliminary X-ray diffraction of human S100A15. (PMID: 16682778) Boeshans K.M. … Ahvazi B. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006) 3 23
  4. Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (PMID: 17620096) Wolf R. … Ruzicka T. (Exp. Dermatol. 2007) 3 23
  5. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 2 3

Products for S100A7A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Death PathwayFinder in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
    • Necrosis in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate S100A7A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for S100A7A
    • Block miRNA regulation of S100A7A using miScript Target Protectors

    Sources for S100A7A Gene

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