Aliases for S100A7 Gene
External Ids for S100A7 Gene
Previous HGNC Symbols for S100A7 Gene
Previous GeneCards Identifiers for S100A7 Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]
GeneCards Summary for S100A7 Gene
S100A7 (S100 Calcium Binding Protein A7) is a Protein Coding gene. Diseases associated with S100A7 include Bladder Squamous Cell Carcinoma and Psoriasis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A7A.