Aliases for S100A7 Gene
External Ids for S100A7 Gene
Previous HGNC Symbols for S100A7 Gene
Previous GeneCards Identifiers for S100A7 Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]
GeneCards Summary for S100A7 Gene
S100A7 (S100 Calcium Binding Protein A7) is a Protein Coding gene. Diseases associated with S100A7 include bladder squamous cell carcinoma and psoriasis. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A7A.