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S100A7 Gene

protein-coding   GIFtS: 59

GC01M151696
S100 calcium binding protein A7
(Previous names: S100 calcium-binding protein A7 (psoriasin 1), S100 calcium binding protein A7 (psoriasin 1) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PSOR1)
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Aliases &
Descriptions
for S100A7

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000015327 2
OTTHUMP00000015328 2
PSOR1 2, 3
Psoriasin 3
S100A7C 3
S100A7c 1, 2
Descriptions
S100 calcium binding protein A7 2
S100 calcium binding protein A7 (psoriasin 1) 1
S100 calcium-binding protein A7 3
S100 calcium-binding protein A7 (psoriasin 1) 1, 2
psoriasin 1 2
External Ids
HGNC: 104971
Entrez Gene: 62782
UniProtKB: P311513
Ensembl: ENSG000001435567
Search outside databases for aliases for S100A7 gene

Previous GC identifers: GC01M151246 GC01M149212 GC01M150205 GC01M150646 GC01M150243

Summaries
for S100A7

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for S100A7:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure
in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly
over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for
familial psoriasis susceptibility. The exact function of this protein is not known. [provided by
RefSeq]

Gene Wiki entry for S100A7

Genomic Location
for S100A7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A7 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151696:     (about GC identifiers)

Start:
 151,696,844 bp from pter
End:
 151,699,761 bp from pter
Size:
 2,918 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  

Proteins
for S100A7

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: S10A7_HUMAN, P31151 (See protein sequence)
Recommended Name: Protein S100-A7  
Size: 101 amino acids; 11471 Da
Subunit: Interacts with RANBP9
Subcellular location: Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway
Mass spectrometry: Mass=11365; Mass_error=0.7; Method=Electrospray; Range=2-101;
Source=PubMed:8526920;
PDB structures from and Proteopedia :
1PSR (3D)    2PSR (3D)    3PSR (3D)    
Secondary accessions: Q5SY67 Q6FGE3 Q9H1E2

REFSEQ proteins: NP_002954.2  

ENSEMBL proteins: 
ENSP00000357712 ENSP00000357711 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Psoriasin)
Human Recombinant Proteins from Abnova (S100A7)
              OriGene Purified Recombinant Human Protein: S100A7 

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region TAS9693957
GO:0005634 nucleus IDA10595935
GO:0005737 cytoplasm TAS9693957
GO:0005783 endoplasmic reticulum IDA12839573
GO:0005829 cytosol IDA12839573
About this table

Antibodies for S100A7: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for S100A7
R&D Systems Antibodies for S100A7
Antibodies from Abcam (Psoriasin), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (S100A7)
Novus Biologicals Antibodies for S100A7

Assays for S100A7: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for S100A7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5 InterPro domains/families:
 IPR018247 EF_HAND_1
 IPR011992 EF-Hand_type
 IPR013787 S100_Ca_bd_sub
 IPR018249 EF_HAND_2
 IPR001751 S100_Ca_bd


   GeneDecks  S100A7 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P31151

ProtoNet protein and cluster: P31151

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10A7_HUMAN, P31151
Similarity: Belongs to the S-101 family
Similarity: Contains 2 EF-hand domains

Gene Function
for S100A7

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (S100A7)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (S100A7)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002963

              Applied Biosystems Silencer® siRNAs for S100A7

              Sigma-Aldrich siRNA for S100A7  
                     Sigma-Aldrich shRNA for S100A7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for S100A7
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002963
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002963
                                 untagged cDNA clone in CMV expression vector: NM_002963 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002963

Genatlas biochemistry entry for S100A7:
S100 calcium binding protein A7,epidermal diffentiation complex,acting as a potent and selective
chemotactic inflammatory protein for CD4+ T lymphocytes,upregulated in psoriasis but not involved
in psoriasis susceptibility

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005509 calcium ion binding IDA8077703
GO:0005515 protein binding NAS15217497
GO:0008270 zinc ion binding NAS10026247
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Pathways & Interactions
for S100A7

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  S100A7 


5/32 Interacting proteins for S100A7 (ENSP000003577113 P311511, 2) via UniProtKB, MINT, and/or STRING (see all 32 )
InteractantInteraction Details
GeneCardExternal ID(s)
RANBP9Q96S591STRING (score=.961) EBI-357520, EBI-636085
PAK7Q9P2861EBI-357520, EBI-1051061
MAP3K3Q997592MINT-48512
COPS5ENSP000003505123STRING (score=.978)
GOT2ENSP000002452063STRING (score=.945)
About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000302 response to reactive oxygen species IDA16082188
GO:0001525 angiogenesis NAS16357139
GO:0008544 epidermis development TAS1940442
GO:0030216 keratinocyte differentiation NAS15740587
GO:0045087 innate immune response NAS15568027
About this table

Drugs & Compounds
for S100A7

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A7
5 Novoseek chemical compound relationships for S100A7 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
pgd2 29.77 1 8618346 (1)
fatty acid 24.86 15 12839573 (6), 10191275 (2), 8618346 (1), 15675957 (1) (see all 7)
calcium 22.88 14 12839573 (3), 9562557 (3), 9693957 (1), 15740587 (1) (see all 7)
zinc 10.89 5 12777802 (1), 10026247 (1), 8982613 (1), 10739916 (1)
oxygen 0.00 6 16082188 (2), 18194266 (2), 16357139 (1)
About this table


Transcripts
for S100A7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (S100A7)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (S100A7)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002963

              Sigma-Aldrich siRNA for S100A7  
                     Sigma-Aldrich shRNA for S100A7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002963  

REFSEQ mRNAs for S100A7 gene: 

NM_002963.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002963  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002963
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002963
                                 untagged cDNA clone in CMV expression vector: NM_002963 

Additional cDNA sequence: 

BC034687.1 CR542164.1 M86757.1 S81991.1 

2 DOTS entries:

DT.111095  DT.91878403 

24/35 AceView cDNA sequences (see all 35 ):

AA583841 AA583738 BC034687 AA583857 AA583726 BX476368 AA583574 AW237898 
AA583990 AA586894 CR542164 AA586769 NM_002963 AA584356 AW238300 AW450143 
M86757 BF088227 AA583822 BM707212 BE710629 AI223193 BE710683 AA586722 

highest scoring ESTs for S100A7:

AW237898 AW238300 BC034687 BE710629 BE710683 BE714132 BE769246 BF090388 M86757 AA583738 

Unigene Cluster for S100A7:

S100 calcium binding protein A7
Hs.112408  [show with all ESTs]
Unigene Representative Sequence: BG680212


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000368723  ENST00000368722  

Expression
for S100A7

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A7 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for S100A7

1 / 2 / 3

3 probe-sets matching S100A7 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

34458_at2, 3 U95-A 2 1.00 0.72 1.00 1.00 AA586894 0.60 1.00 0.82 1

205916_at2, 3 U133-A 2 1.00 0.59 -- -- NM_002963 0.60 1.00 0.82 1

205916_at2 U133Plus2 2 1.00 0.59 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAGCAGCGCC

SOURCE GeneReport for Unigene cluster: Hs.112408

Expression variation in blood from EXPOLDB for S100A7

UniProtKB/Swiss-Prot: S10A7_HUMAN, P31151
Tissue specificity: Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in
psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC)
bearing patients

Orthologs
for S100A7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for S100A7 gene from 2 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 S100A71   -- S100 calcium binding protein A7 97.36(n)
96.04(a)		 469501  XM_001138567.1  XP_001138567.1 
cow
(Bos taurus)		 LOC6182691   -- similar to BDA11 80.2(n)
69.31(a)		 618269  XM_870600.2  XP_875693.1 
About this table        Species with no ortholog for S100A7

ENSEMBL Gene Tree for S100A7

Paralogs
for S100A7

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for S100A7 gene
S100A7A2  S100A7L22  

SNPs/Variants
for S100A7

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/36 NCBI SNPs in S100A7 are shown (see all 36 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 21)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs30064331,2
A,C,F,H,O151700316(+) ATCATC/TATATG 1 -- ng318Minor allele frequency- N:0.01EA NA EU WA 634
rs42624821,2
A,C,F,H151699973(+) TCAACC/ATTGAT 1 -- ng31 tfbs34Minor allele frequency- A:0.01EU EA WA 420
--
rs112052971,2
A,C,F,H151700320(+) TTATAT/CGGACT 1 -- ng318Minor allele frequency- C:0.31EU EA WA 824
rs30148371,2
C,F,H151698030(+) GGCTTG/CTCAAT 1 D/E mis18Minor allele frequency- C:0.02EU EA WA 828
--
rs42797941,2
A151699909(+) GCCAGG/TGTCCC 1 -- ng310--------
--
rs31242141,2
H151700382(+) GGGTCA/GCATCA 1 -- ng314Minor allele frequency- G:0.00EU EA WA 416
rs31242131,2
H151700231(+) TAGTCC/TTAAGA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 416
--
rs124083141,2
C151699765(+) ACAAAC/GAGCAG 1 -- ng31 ese30--------
rs30148381,2
A,C,F,H,O151698889(+) CCAAGG/CCTTGA 1 -- int16Minor allele frequency- C:0.20EA WA NA 440
rs30148391,2
A,C,F,H151699364(+) GGAGCC/TGGAGC 1 -- int14Minor allele frequency- T:0.18EU EA WA 416
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HapMap Linkage Disequilibrium images for S100A7 (up to first 250kb)

Disorders & Mutations
for S100A7

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 600353

10/22 Novoseek disease relationships for S100A7 gene (see all 22 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell bladder 85.86 4 8618345 (2), 10197442 (1)
psoriasis 77.34 47 18060647 (3), 19016707 (3), 19162067 (1), 8530009 (1) (see all 22)
carcinoma ductal 59.57 16 12855640 (3), 15217497 (2), 16357139 (1), 15740587 (1) (see all 7)
comedo 55.29 3 17033192 (1), 11782356 (1), 8840971 (1)
skin diseases 52.15 11 8844119 (2), 16273201 (1), 18194266 (1), 8526920 (1) (see all 8)
skin lesion 49.17 15 18060647 (2), 19016707 (1), 17136347 (1), 16965334 (1)
dermatitis atopic 37.99 4 8844119 (1), 18754038 (1)
carcinoma squamous cell 37.29 12 18364444 (5), 18223693 (2), 16675044 (1), 17136347 (1) (see all 6)
breast carcinoma 35.02 8 16357139 (1), 17560571 (1), 11782356 (1), 7591220 (1) (see all 5)
carcinoma lobular 31.34 1 15201992 (1)
About this table

Human Genome Epidemiology Navigator: S100A7 (1 document)

Medical News
for S100A7

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for S100A7

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/134 PubMed articles for S100A7 gene (see all 134 ):

Search for S100A7

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing S100A7

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 6278 HGNC: 10497 AceView: S100A7 Ensembl:ENSG00000143556 euGenes: HUgn6278
ECgene: S100A7 H-InvDB: S100A7

Other Databases showing S100A7

(According to HUGE)
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   --

Specialized Databases showing S100A7

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for S100A7 Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies
for S100A7

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for S100A7

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for S100A7:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for S100A7-related products

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 Predesigned and custom siRNAs for S100A7 Antibodies for S100A7
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for S100A7 Browse small molecules at Sigma-Aldrich
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(Psoriasin)
 Antibodies (Psoriasin)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for S100A7




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for S100A7

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