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Aliases for S100A7 Gene

Aliases for S100A7 Gene

  • S100 Calcium Binding Protein A7 2 3 5
  • S100 Calcium-Binding Protein A7 (Psoriasin 1) 2 3
  • S100A7c 3 4
  • PSOR1 3 4
  • S100 Calcium Binding Protein A7 (Psoriasin 1) 2
  • S100 Calcium-Binding Protein A7 4
  • Psoriasin 1 3
  • Psoriasin 4

External Ids for S100A7 Gene

Previous HGNC Symbols for S100A7 Gene

  • PSOR1

Previous GeneCards Identifiers for S100A7 Gene

  • GC01M151246
  • GC01M149212
  • GC01M150205
  • GC01M150646
  • GC01M150243
  • GC01M151696
  • GC01M124793

Summaries for S100A7 Gene

Entrez Gene Summary for S100A7 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

GeneCards Summary for S100A7 Gene

S100A7 (S100 Calcium Binding Protein A7) is a Protein Coding gene. Diseases associated with S100A7 include bladder squamous cell carcinoma and psoriasis. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A7A.

Gene Wiki entry for S100A7 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A7 Gene

Genomics for S100A7 Gene

Regulatory Elements for S100A7 Gene

Genomic Location for S100A7 Gene

Chromosome:
1
Start:
153,457,744 bp from pter
End:
153,460,701 bp from pter
Size:
2,958 bases
Orientation:
Minus strand

Genomic View for S100A7 Gene

Genes around S100A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A7 Gene

Proteins for S100A7 Gene

  • Protein details for S100A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31151-S10A7_HUMAN
    Recommended name:
    Protein S100-A7
    Protein Accession:
    P31151
    Secondary Accessions:
    • Q5SY67
    • Q6FGE3
    • Q9H1E2

    Protein attributes for S100A7 Gene

    Size:
    101 amino acids
    Molecular mass:
    11471 Da
    Quaternary structure:
    • Interacts with RANBP9.

    Three dimensional structures from OCA and Proteopedia for S100A7 Gene

neXtProt entry for S100A7 Gene

Proteomics data for S100A7 Gene at MOPED

Post-translational modifications for S100A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S100A7 Gene

Domains & Families for S100A7 Gene

Suggested Antigen Peptide Sequences for S100A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31151

UniProtKB/Swiss-Prot:

S10A7_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A7: view

Function for S100A7 Gene

Molecular function for S100A7 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A7,epidermal diffentiation complex,acting as a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes,upregulated in psoriasis but not involved in psoriasis susceptibility

Gene Ontology (GO) - Molecular Function for S100A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050786 RAGE receptor binding IPI 18606705
genes like me logo Genes that share ontologies with S100A7: view
genes like me logo Genes that share phenotypes with S100A7: view

Animal Model Products

miRNA for S100A7 Gene

miRTarBase miRNAs that target S100A7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A7 Gene

Localization for S100A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A7 Gene

Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A7 Gene COMPARTMENTS Subcellular localization image for S100A7 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for S100A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9693957
genes like me logo Genes that share ontologies with S100A7: view

Pathways & Interactions for S100A7 Gene

genes like me logo Genes that share pathways with S100A7: view

Pathways by source for S100A7 Gene

1 BioSystems pathway for S100A7 Gene

Gene Ontology (GO) - Biological Process for S100A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species IDA 16082188
GO:0001525 angiogenesis NAS 16357139
GO:0008544 epidermis development TAS 1940442
GO:0050829 defense response to Gram-negative bacterium IMP 15568027
GO:0090026 positive regulation of monocyte chemotaxis IDA 18606705
genes like me logo Genes that share ontologies with S100A7: view

No data available for SIGNOR curated interactions for S100A7 Gene

Drugs & Compounds for S100A7 Gene

(4) Drugs for S100A7 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Anilino-8-Naphthalene Sulfonate Experimental Pharma Target 0

(4) Additional Compounds for S100A7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A7: view

Transcripts for S100A7 Gene

mRNA/cDNA for S100A7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A7 Gene

S100 calcium binding protein A7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A7 Gene

No ASD Table

Relevant External Links for S100A7 Gene

GeneLoc Exon Structure for
S100A7
ECgene alternative splicing isoforms for
S100A7

Expression for S100A7 Gene

mRNA expression in normal human tissues for S100A7 Gene

mRNA differential expression in normal tissues according to GTEx for S100A7 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.2), Vagina (x16.4), Minor Salivary Gland (x7.1), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for S100A7 Gene

This gene is overexpressed in Oral epithelium (24.2), Stomach (13.3), and Esophagus (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A7 Gene



SOURCE GeneReport for Unigene cluster for S100A7 Gene Hs.112408

mRNA Expression by UniProt/SwissProt for S100A7 Gene

P31151-S10A7_HUMAN
Tissue specificity: Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
genes like me logo Genes that share expression patterns with S100A7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for S100A7 Gene

Orthologs for S100A7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A7 35
  • 79.87 (n)
  • 68.32 (a)
-- 36
  • 68 (a)
ManyToMany
S100A7 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia S100A7 35
  • 97.36 (n)
  • 96.04 (a)
S100A7 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
Species with no ortholog for S100A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A7 Gene

ENSEMBL:
Gene Tree for S100A7 (if available)
TreeFam:
Gene Tree for S100A7 (if available)

Paralogs for S100A7 Gene

Paralogs for S100A7 Gene

(7) SIMAP similar genes for S100A7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A7: view

Variants for S100A7 Gene

Sequence variations from dbSNP and Humsavar for S100A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3014837 - 153,458,930(+) GGCTT(C/G)TCAAT reference, missense
rs1133002 -- 153,457,941(-) GCCGA(C/T)GTCTT reference, synonymous-codon
rs3014836 -- 153,458,724(+) TTTTT(C/T)GCCTA intron-variant
rs3014838 -- 153,459,789(+) CCAAG(C/G)CTTGA intron-variant
rs3014839 -- 153,460,264(+) GGAGC(C/T)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A7 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Variation tolerance for S100A7 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A7 Gene

HapMap Linkage Disequilibrium report
S100A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A7 Gene

Disorders for S100A7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for S100A7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder squamous cell carcinoma
  • epidermoid carcinoma of the urinary bladder
psoriasis
trachea leiomyoma
  • tracheal neoplasm
porokeratosis
  • disseminated superficial actinic porokeratosis
skin disease
  • dermatitis due to substances taken internally
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A7

Genetic Association Database (GAD)
S100A7
Human Genome Epidemiology (HuGE) Navigator
S100A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A7
genes like me logo Genes that share disorders with S100A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A7 Gene

Publications for S100A7 Gene

  1. Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. (PMID: 1940442) Madsen P. … Celis J.E. (J. Invest. Dermatol. 1991) 2 3 4 23 67
  2. S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. (PMID: 20101226) West N.R. … Watson P.H. (Oncogene 2010) 3 23
  3. Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. (PMID: 20226301) Tieu D.D. … Schleimer R.P. (J. Allergy Clin. Immunol. 2010) 3 23
  4. The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption. (PMID: 18754038) GlAoser R. … Schwarz T. (J. Invest. Dermatol. 2009) 3 23
  5. S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. (PMID: 19159013) Qin W. … Pasinetti G.M. (PLoS ONE 2009) 3 23

Products for S100A7 Gene

Sources for S100A7 Gene

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