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S100A7 Gene

protein-coding   GIFtS: 66
GCID: GC01M153430

S100 Calcium Binding Protein A7

(Previous names: S100 calcium-binding protein A7 (psoriasin 1), S100 calcium...)
(Previous symbol: PSOR1)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A71 2     Protein S100-A72
PSOR11 2 3     Psoriasin 12
S100 Calcium-Binding Protein A7 (Psoriasin 1)1 2     Psoriasin3
S100 Calcium Binding Protein A7 (Psoriasin 1)1     S100A7C3
S100A7c2     S100 Calcium-Binding Protein A73

External Ids:    HGNC: 104971   Entrez Gene: 62782   Ensembl: ENSG000001435567   OMIM: 6003535   UniProtKB: P311513   

Export aliases for S100A7 gene to outside databases

Previous GC identifers: GC01M151246 GC01M149212 GC01M150205 GC01M150646 GC01M150243 GC01M151696 GC01M124793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A7 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the
other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus.
This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate
gene for familial psoriasis susceptibility. The exact function of this protein is not known. (provided by RefSeq,
Jul 2008)

GeneCards Summary for S100A7 Gene:
S100A7 (S100 calcium binding protein A7) is a protein-coding gene. Diseases associated with S100A7 include trachea leiomyoma, and breast apocrine carcinoma. GO annotations related to this gene include RAGE receptor binding and calcium ion binding. An important paralog of this gene is S100A7A.

Gene Wiki entry for S100A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A7 gene promoter:
         AP-1   NRSF form 1   ATF-2   LUN-1   NF-kappaB   NRSF form 2   STAT3   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A7 promoter sequence
   Search Chromatin IP Primers for S100A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153430:  view genomic region     (about GC identifiers)

Start:
153,430,220 bp from pter      End:
153,433,177 bp from pter
Size:
2,958 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S10A7_HUMAN, P31151 (See protein sequence)
Recommended Name: Protein S100-A7  
Size: 101 amino acids; 11471 Da
Subunit: Interacts with RANBP9
Mass spectrometry: Mass=11365; Mass_error=0.7; Method=Electrospray; Range=2-101; Source=PubMed:8526920;
Selected PDB 3D structures from and Proteopedia for S100A7 (see all 7):
1PSR (3D)        2PSR (3D)        2WND (3D)        2WOR (3D)        2WOS (3D)        3PSR (3D)    
Secondary accessions: Q5SY67 Q6FGE3 Q9H1E2

Explore the universe of human proteins at neXtProt for S100A7: NX_P31151

Explore proteomics data for S100A7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See S100A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002954.2  
    ENSEMBL proteins: 
     ENSP00000357711   ENSP00000357712  

    S100A7 Human Recombinant Protein Products:

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    S100A7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for S100A7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    Selected InterPro protein domains (see all 6):
     IPR028477 S100A7
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P31151

    ProtoNet protein and cluster: P31151

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A7_HUMAN, P31151
    Similarity: Belongs to the S-101 family
    Similarity: Contains 2 EF-hand domains


    S100A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for S100A7:
    S100 calcium binding protein A7,epidermal diffentiation complex,acting as a potent and selective chemotactic
    inflammatory protein for CD4+ T lymphocytes,upregulated in psoriasis but not involved in psoriasis susceptibility

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA8077703
    GO:0005515protein binding IPI12421467
    GO:0008270zinc ion binding NAS10026247
    GO:0050786RAGE receptor binding IPI18606705
         
    S100A7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for S100A7:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S100A7
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S100A7

    miRNA
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    miRTarBase miRNAs that target S100A7:
    hsa-mir-26b-5p (MIRT030103)

    Block miRNA regulation of human, mouse, rat S100A7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate S100A7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat S100A7

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    GenScript: all cDNA clones in your preferred vector: S100A7 (NM_002963)
    Sino Biological Human cDNA Clone for S100A7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S10A7_HUMAN, P31151: Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    extracellular5
    nucleus5
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS9693957
    GO:0005634nucleus IDA10595935
    GO:0005737cytoplasm TAS9693957
    GO:0005783endoplasmic reticulum IDA12839573
    GO:0005829cytosol IDA12839573

    S100A7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S100A7 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression


    1 BioSystems Pathway for S100A7
        Validated targets of C-MYC transcriptional repression



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for S100A7
    Interactions:

        GeneGlobe Interaction Network for S100A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for S100A7 (P311511, 2, 3 ENSP000003577114) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP9Q96S591, 3, ENSP000000116194EBI-357520,EBI-636085 I2D: score=4 STRING: ENSP00000011619
    MAP3K3Q997592, 3MINT-48512 I2D: score=2 
    COPS5Q929053, ENSP000003505124I2D: score=4 STRING: ENSP00000350512
    LIN9Q5TKA13, ENSP000003291024I2D: score=1 STRING: ENSP00000329102
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IDA16082188
    GO:0001525angiogenesis NAS16357139
    GO:0008544epidermis development TAS1940442
    GO:0010820positive regulation of T cell chemotaxis IDA18606705
    GO:0030216keratinocyte differentiation NAS15740587

    S100A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for S100A7 (S10A7)

    1 DrugBank Compound for S100A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Anilino-8-Naphthalene Sulfonate-- --target--10592235

    7 Novoseek inferred chemical compound relationships for S100A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgd2 27.1 1 8618346 (1)
    calcium 25.1 16 12839573 (3), 9562557 (3), 9693957 (1), 19844956 (1) (see all 8)
    fatty acid 21.3 15 12839573 (6), 10191275 (2), 8618346 (1), 15675957 (1) (see all 7)
    zinc 18.5 8 19386136 (1), 19844956 (1), 12777802 (1), 10026247 (1) (see all 6)
    estrogen 7.03 12 17009105 (2), 12855640 (2), 16357139 (1), 18534028 (1) (see all 6)
    oxygen 0 6 16082188 (2), 18194266 (2), 16357139 (1)
    retinoic acid 0 5 8931868 (2)



    S100A7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for S100A7 gene: 
    NM_002963.3  

    Unigene Cluster for S100A7:

    S100 calcium binding protein A7
    Hs.112408  [show with all ESTs]
    Unigene Representative Sequence: BG680212
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368722 ENST00000368723(uc001fbv.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat S100A7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate S100A7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat S100A7
    Clone
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    OriGene clones in human, mouse for S100A7 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: S100A7 (NM_002963)
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    Primer
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    OriGene qPCR primer pairs and template standards for S100A7
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat S100A7
      QuantiTect SYBR Green Assays in human, mouse, rat S100A7
      QuantiFast Probe-based Assays in human, mouse, rat S100A7

    Additional mRNA sequence: 

    BC034687.1 CR542164.1 M86757.1 S81991.1 

    2 DOTS entries:

    DT.111095  DT.91878403 

    Selected AceView cDNA sequences (see all 35):

    AA583841 BX476368 AA586769 AA583726 CR542164 AA583990 AA583857 BC034687 
    AW237898 NM_002963 AA583738 AA584356 AA586894 AA583574 AW450143 BF088227 
    M86757 AA583822 AW238300 BM707212 BE710683 BE710629 AI223193 AA586722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S100A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGCGCC
    S100A7 Expression
    About this image

    S100A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S100A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112408

    UniProtKB/Swiss-Prot: S10A7_HUMAN, P31151
    Tissue specificity: Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis.
    Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients

        Custom PCR Arrays for S100A7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for S100A7 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    Uncharacterized protein
    31(a)
    1 → many
    2(187744792-187750533)


    ENSEMBL Gene Tree for S100A7 (if available)
    TreeFam Gene Tree for S100A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S100A7 gene
    S100A7A2  S100A7L22  
    7 SIMAP similar genes for S100A7 using alignment to 1 protein entry:     S10A7_HUMAN:
    S100A7A    S100A7L2    S100A7L3    S100Z    S100A11    S100A12
    S100A8

    S100A7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S100A7 (see all 157)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427169501,2
    --153429776(+) CTGAGC/TCTGAT 1 -- ds50010--------
    rs1880341871,2
    --153429803(+) TATGTA/GAGTGG 1 -- ds50010--------
    rs1923683221,2
    --153429861(+) GGCAGC/GAGCAC 1 -- ds50010--------
    rs1473711801,2
    --153429876(+) AGAGAC/TGCCAG 1 -- ds50010--------
    rs1148834591,2
    F--153429878(+) AGATGC/TCAGCC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1379905731,2
    --153429885(+) AGCCCA/CTTCTC 1 -- ds50010--------
    rs1855121091,2
    --153430052(+) TGTGAC/GAGGCA 1 -- ds50010--------
    rs66847211,2
    C--153430059(+) GGCAGA/CTCAGC 1 -- ds50010--------
    rs1904837971,2
    --153430184(+) CAACGC/TAGGTC 1 -- ds50010--------
    rs1920154221,2
    --153430199(+) AAGAGA/CAGAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for S100A7 (153430220 - 153433177 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for S100A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831603CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A7
    DNA2.0 Custom Variant and Variant Library Synthesis for S100A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600353    OMIM disorders: --

    Selected diseases for S100A7 (see all 44):    
    About MalaCards
    trachea leiomyoma    breast apocrine carcinoma    bladder squamous cell carcinoma    anal fistula
    lung squamous cell carcinoma    middle ear cholesteatoma    psoriasis    tuberous sclerosis complex
    lichen sclerosus    ductal carcinoma in situ    oral leukoplakia    large cell carcinoma
    porokeratosis    trachoma    kidney cancer    leukoplakia
    skin disease    tuberous sclerosis    cholesteatoma    acne

    4 diseases from the University of Copenhagen DISEASES database for S100A7:
    Psoriasis     Ductal carcinoma in situ     Trachea leiomyoma     Trachoma

    S100A7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for S100A7 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell bladder 84.7 4 8618345 (2), 10197442 (1)
    psoriasis 77.8 51 18060647 (3), 19016707 (3), 19162067 (1), 20107483 (1) (see all 25)
    carcinoma ductal 56.9 16 12855640 (3), 15217497 (2), 16357139 (1), 15740587 (1) (see all 7)
    skin diseases 53.2 11 8844119 (2), 16273201 (1), 18194266 (1), 8526920 (1) (see all 8)
    comedo 52.7 3 17033192 (1), 11782356 (1), 8840971 (1)
    skin lesion 46.3 15 18060647 (2), 19016707 (1), 17136347 (1), 16965334 (1)
    dermatitis atopic 39.2 4 8844119 (1), 18754038 (1)
    carcinoma squamous cell 38.6 17 18364444 (5), 18223693 (2), 19147391 (2), 16675044 (1) (see all 8)
    breast carcinoma 32.1 8 16357139 (1), 17560571 (1), 11782356 (1), 7591220 (1) (see all 5)
    breast cancer 31.2 38 15201992 (4), 20101226 (4), 17560571 (2), 15217486 (2) (see all 14)

    Genetic Association Database (GAD): S100A7
    Human Genome Epidemiology (HuGE) Navigator: S100A7 (5 documents)

    Export disorders for S100A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S100A7 gene, integrated from 10 sources (see all 199):
    (articles sorted by number of sources associating them with S100A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. (PubMed id 1940442)1, 2, 3, 9 Madsen P.... Celis J.E. (J. Invest. Dermatol. 1991)
    2. Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis. (PubMed id 18373864)1, 4, 9 Bryborn M....Cardell L.O. (Respir. Res. 2008)
    3. EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing. (PubMed id 9562557)1, 2, 9 Brodersen D.E.... Kjeldgaard M. (Structure 1998)
    4. Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PubMed id 12664160)1, 2, 9 Kulski J.K.... Bellgard M. (J. Mol. Evol. 2003)
    5. Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. (PubMed id 8618345)1, 2, 9 Celis J.E....Orntoft T.F. (J. Urol. 1996)
    6. Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry. (PubMed id 8526920)1, 2, 9 Burgisser D.M.... Heizmann C.W. (Biochem. Biophys. Res. Commun. 1995)
    7. Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+- free states. (PubMed id 10026247)1, 2, 9 Brodersen D.E.... Kjeldgaard M. (Biochemistry 1999)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6278 HGNC: 10497 AceView: S100A7 Ensembl:ENSG00000143556 euGenes: HUgn6278
    ECgene: S100A7 H-InvDB: S100A7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S100A7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S100A7 gene:
    Search GeneIP for patents involving S100A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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