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Aliases for S100A6 Gene

Aliases for S100A6 Gene

  • S100 Calcium Binding Protein A6 2 3
  • CACY 3 4 6
  • S100 Calcium-Binding Protein A6 (Calcyclin) 2 3
  • Prolactin Receptor-Associated Protein 3 4
  • Growth Factor-Inducible Protein 2A9 3 4
  • Calcyclin 3 4
  • MLN 4 3 4
  • PRA 3 4
  • S100 Calcium Binding Protein A6 (Calcyclin) 2
  • S100 Calcium-Binding Protein A6 4
  • Protein S100-A6 3
  • 5B10 3
  • CABP 3
  • 2A9 3

External Ids for S100A6 Gene

Previous Symbols for S100A6 Gene

  • CACY

Summaries for S100A6 Gene

Entrez Gene Summary for S100A6 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A6 Gene

S100A6 (S100 Calcium Binding Protein A6) is a Protein Coding gene. Diseases associated with S100A6 include cutaneous ganglioneuroma and endometrial cancer. Among its related pathways are Gastric cancer network 2 and Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A12.

UniProtKB/Swiss-Prot for S100A6 Gene

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.

Gene Wiki entry for S100A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A6 Gene

Genomics for S100A6 Gene

Genomic Location for S100A6 Gene

Start:
153,534,599 bp from pter
End:
153,536,244 bp from pter
Size:
1,646 bases
Orientation:
Minus strand

Genomic View for S100A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A6 Gene

Regulatory Elements for S100A6 Gene

Transcription factor binding sites by QIAGEN in the S100A6 gene promoter:

Proteins for S100A6 Gene

  • Protein details for S100A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06703-S10A6_HUMAN
    Recommended name:
    Protein S100-A6
    Protein Accession:
    P06703
    Secondary Accessions:
    • D3DV39
    • Q5RHS4

    Protein attributes for S100A6 Gene

    Size:
    90 amino acids
    Molecular mass:
    10180 Da
    Quaternary structure:
    • Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    Miscellaneous:
    • This protein co-purified with the prolactin receptor

    Three dimensional structures from OCA and Proteopedia for S100A6 Gene

neXtProt entry for S100A6 Gene

Proteomics data for S100A6 Gene at MOPED

Post-translational modifications for S100A6 Gene

Other Protein References for S100A6 Gene

No data available for DME Specific Peptides for S100A6 Gene

Domains for S100A6 Gene

Gene Families for S100A6 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

UniProtKB/Swiss-Prot:

S10A6_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • P06703
Family:
  • Belongs to the S-100 family.:
    • P06703
genes like me logo Genes that share domains with S100A6: view

Function for S100A6 Gene

Molecular function for S100A6 Gene

GENATLAS Biochemistry: S100 calcium binding protein A6,10.2kDa,epidermal differentiation complex
UniProtKB/Swiss-Prot Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
UniProtKB/Swiss-Prot Induction: Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias

Gene Ontology (GO) - Molecular Function for S100A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 12577318
GO:0005515 protein binding IPI 10913138
GO:0005523 tropomyosin binding IDA 19724273
GO:0008270 zinc ion binding IEA --
GO:0015075 ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with S100A6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for S100A6 Gene

Localization for S100A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A6 Gene

Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A6 Gene COMPARTMENTS Subcellular localization image for S100A6 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for S100A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 10913138
GO:0005634 nucleus IDA 10913138
GO:0005635 nuclear envelope NAS 12577318
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol IDA 19724273
genes like me logo Genes that share ontologies with S100A6: view

Pathways for S100A6 Gene

genes like me logo Genes that share pathways with S100A6: view

Pathways by source for S100A6 Gene

Gene Ontology (GO) - Biological Process for S100A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 16130169
GO:0007409 axonogenesis NAS 12152788
GO:0034220 ion transmembrane transport IEA --
GO:0048146 positive regulation of fibroblast proliferation NAS 12577318
genes like me logo Genes that share ontologies with S100A6: view

Compounds for S100A6 Gene

(28) Novoseek inferred chemical compound relationships for S100A6 Gene

Compound -log(P) Hits PubMed IDs
progesterone 62.7 43
17beta-hydroxysteroid 59 3
calcium 47.4 51
progestin 38 9
glyceraldehyde 3-phosphate 35.3 4
genes like me logo Genes that share compounds with S100A6: view

Transcripts for S100A6 Gene

mRNA/cDNA for S100A6 Gene

Unigene Clusters for S100A6 Gene

S100 calcium binding protein A6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: -

Relevant External Links for S100A6 Gene

GeneLoc Exon Structure for
S100A6
ECgene alternative splicing isoforms for
S100A6

Expression for S100A6 Gene

mRNA expression in normal human tissues for S100A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A6 Gene

This gene is overexpressed in Whole Blood (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A6 Gene

SOURCE GeneReport for Unigene cluster for S100A6 Gene Hs.275243

genes like me logo Genes that share expressions with S100A6: view

Orthologs for S100A6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A6 36
  • 99.63 (n)
  • 100 (a)
S100A6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100A6 36
  • 86.05 (n)
  • 79.07 (a)
dog
(Canis familiaris)
Mammalia S100A6 36
  • 92.59 (n)
  • 91.11 (a)
S100A6 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100a6 36
  • 93.26 (n)
  • 96.63 (a)
S100a6 16
S100a6 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A6 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100A6 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a6 36
  • 92.51 (n)
  • 95.51 (a)
chicken
(Gallus gallus)
Aves S100A6 36
  • 84.85 (n)
  • 88.64 (a)
Species with no ortholog for S100A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A6 Gene

ENSEMBL:
Gene Tree for S100A6 (if available)
TreeFam:
Gene Tree for S100A6 (if available)

Paralogs for S100A6 Gene

Selected SIMAP similar genes for S100A6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with S100A6: view

Variants for S100A6 Gene

Sequence variations from dbSNP and Humsavar for S100A6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11094 -- 153,534,783(-) GACCG(G/T)AACAA reference, synonymous-codon
rs11973 -- 153,534,629(+) GTACA(A/T)TTACC utr-variant-3-prime
rs11974 - 153,535,260(-) CAAGC(A/G)CACCC reference, missense
rs659403 -- 153,535,483(-) GATGC(C/G)ATTGT intron-variant
rs1802581 - 153,534,763(+) GGAAG(C/T)TCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for S100A6 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Relevant External Links for S100A6 Gene

HapMap Linkage Disequilibrium report
S100A6

Disorders for S100A6 Gene

(1) University of Copenhagen DISEASES for S100A6 Gene

(50) Novoseek inferred disease relationships for S100A6 Gene

Disease -log(P) Hits PubMed IDs
ehrlich ascites tumor 57.4 9
endometrial cancer 56.3 18
tumors 43.8 78
nevi melanocytic 41.4 5
melanoma 35.5 33

Relevant External Links for S100A6

Genetic Association Database (GAD)
S100A6
Human Genome Epidemiology (HuGE) Navigator
S100A6
genes like me logo Genes that share disorders with S100A6: view

No data available for UniProtKB/Swiss-Prot for S100A6 Gene

Publications for S100A6 Gene

  1. Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. (PMID: 11937060) Otterbein L.R. … Dominguez R. (Structure 2002) 3 4 23
  2. Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. (PMID: 12601007) Tomas A. … Moss S.E. (J. Biol. Chem. 2003) 3 4 23
  3. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (PMID: 19724273) Nedjadi T. … Costello E. (Br. J. Cancer 2009) 3 4 23
  4. Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. (PMID: 19834903) Zimmermann S. … Martens U.M. (Proteomics 2009) 3 23
  5. Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients. (PMID: 19888321) Wei B.R. … Simpson R.M. (PLoS ONE 2009) 3 23

Products for S100A6 Gene

Sources for S100A6 Gene

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