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S100A6 Gene

protein-coding   GIFtS: 63
GCID: GC01M153507

S100 Calcium Binding Protein A6

(Previous names: S100 calcium-binding protein A6 (calcyclin), S100 calcium...)
(Previous symbol: CACY)
  See S100A6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A61 2     2A92
CACY1 2 3 5     5B102
S100 Calcium-Binding Protein A6 (Calcyclin)1 2     CABP2
Growth Factor-Inducible Protein 2A92 3     calcyclin2
Prolactin Receptor-Associated Protein2 3     Protein S100-A62
PRA2 3     Calcyclin3
MLN 42 3     S100 Calcium-Binding Protein A63
S100 Calcium Binding Protein A6 (Calcyclin)1     

External Ids:    HGNC: 104961   Entrez Gene: 62772   Ensembl: ENSG000001979567   OMIM: 1141105   UniProtKB: P067033   

Export aliases for S100A6 gene to outside databases

Previous GC identifers: GC01M151323 GC01M149289 GC01M150334 GC01M150775 GC01M150320 GC01M151774 GC01M124870


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A6 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in
stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal
rearrangements and altered expression of this gene have been implicated in melanoma. (provided by RefSeq, Jul
2008)

GeneCards Summary for S100A6 Gene:
S100A6 (S100 calcium binding protein A6) is a protein-coding gene. Diseases associated with S100A6 include cutaneous ganglioneuroma, and uterine corpus cancer. GO annotations related to this gene include calcium-dependent protein binding and calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703
Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function
by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many
physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2
calcium ions. Calcium binding is cooperative

Gene Wiki entry for S100A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A6 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A6 promoter sequence
   Search Chromatin IP Primers for S100A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153507:  view genomic region     (about GC identifiers)

Start:
153,507,075 bp from pter      End:
153,508,720 bp from pter
Size:
1,646 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703 (See protein sequence)
Recommended Name: Protein S100-A6  
Size: 90 amino acids; 10180 Da
Subunit: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner.
Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity
for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on
its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats);
the interaction is calcium-dependent and modulates PPP5C activity
Miscellaneous: This protein co-purified with the prolactin receptor
4 PDB 3D structures from and Proteopedia for S100A6:
1K8U (3D)        1K96 (3D)        1K9K (3D)        1K9P (3D)    
Secondary accessions: D3DV39 Q5RHS4

Explore the universe of human proteins at neXtProt for S100A6: NX_P06703

Explore proteomics data for S100A6 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See S100A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055439.1  
    ENSEMBL proteins: 
     ENSP00000473589   ENSP00000357708   ENSP00000357709   ENSP00000473547  

    S100A6 Human Recombinant Protein Products:

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    antibodies-online proteins for S100A6 (35 products) 

     
    antibodies-online peptides for S100A6

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    S100A6 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    Selected InterPro protein domains (see all 6):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR018247 EF_Hand_1_Ca_BS
     IPR028497 S100-A5/S100-A6

    Graphical View of Domain Structure for InterPro Entry P06703

    ProtoNet protein and cluster: P06703

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Find genes that share domains with S100A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S10A6_HUMAN, P06703
    Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function
    by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many
    physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2
    calcium ions. Calcium binding is cooperative
    Induction: Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by
    growth factors and overexpressed in acute myeloid leukemias

         Genatlas biochemistry entry for S100A6:
    S100 calcium binding protein A6,10.2kDa,epidermal differentiation complex

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS12577318
    GO:0005515protein binding IPI10913138
    GO:0005523tropomyosin binding IDA19724273
    GO:0008270zinc ion binding IEA--
    GO:0015075ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with S100A6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for S100A6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S10A6_HUMAN, P06703: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    cytoskeleton2
    mitochondrion2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA10913138
    GO:0005634nucleus IDA10913138
    GO:0005635nuclear envelope NAS12577318
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol IDA19724273

    Find genes that share ontologies with S100A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S100A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation
    2Gastric cancer network 2
    Gastric cancer network 2


    2 BioSystems Pathways for S100A6
        Gastric cancer network 2
    Prostaglandin Synthesis and Regulation



        Pathway & Disease-focused RT2 Profiler PCR Arrays including S100A6: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Estrogen Receptor Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for S100A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for S100A6 (P067031, 2, 3 ENSP000003577084) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FKBP4Q027901, 2, 3, ENSP000000010084EBI-352877,EBI-1047444 MINT-7710442 MINT-7710387 MINT-7710488 I2D: score=1 STRING: ENSP00000001008
    MDM2Q009871, 2, 3, ENSP000004172814EBI-352877,EBI-389668 MINT-7905130 MINT-7905256 I2D: score=2 STRING: ENSP00000417281
    TP53P046372, 3, ENSP000002693054MINT-7905207 I2D: score=1 STRING: ENSP00000269305
    KPNA2P522921, 2, 3, ENSP000003324554EBI-352877,EBI-349938 MINT-8044928 MINT-8045257 MINT-8044941 I2D: score=1 STRING: ENSP00000332455
    S100BP042711, 3, ENSP000002917004EBI-352877,EBI-458391 I2D: score=4 STRING: ENSP00000291700
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS16130169
    GO:0007409axonogenesis NAS12152788
    GO:0034220ion transmembrane transport ----
    GO:0048146positive regulation of fibroblast proliferation NAS12577318

    Find genes that share ontologies with S100A6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for S100A6 (S10A6)

    Selected Novoseek inferred chemical compound relationships for S100A6 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 62.7 63 11389093 (3), 11830547 (3), 19499404 (3), 14682477 (2) (see all 34)
    17beta-hydroxysteroid 59 3 12829805 (1), 15731358 (1), 12780745 (1)
    calcium 47.4 77 9578461 (4), 2358072 (3), 1467312 (3), 7645757 (2) (see all 36)
    progestin 38 16 10517668 (6), 14519093 (2), 15657363 (1)
    glyceraldehyde 3-phosphate 35.3 6 7584597 (2), 16220529 (1), 1999197 (1)
    estrogen 28.3 9 11918216 (2), 18996480 (1), 16006726 (1), 19367380 (1) (see all 7)
    progestins 27.3 1 14519093 (1)
    steroid 26.6 6 8808831 (2), 1733083 (1), 1320051 (1), 18064567 (1) (see all 5)
    bapta 25.3 3 12810055 (2), 17466273 (1)
    retinoic acid 14.3 1 1727370 (1)



    Find genes that share compounds with S100A6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for S100A6 gene: 
    NM_014624.3  

    Unigene Cluster for S100A6:

    S100 calcium binding protein A6
    Hs.275243  [show with all ESTs]
    Unigene Representative Sequence: BM904612
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496817 ENST00000368719(uc001fbw.1) ENST00000368720 ENST00000462776
    ENST00000462951
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat S100A6
      QuantiFast Probe-based Assays in human, mouse, rat S100A6

    Additional mRNA sequence: 

    AK312088.1 BC001431.2 BC009017.1 BT006965.1 

    Selected DOTS entries (see all 27):

    DT.99926466  DT.92456063  DT.97856358  DT.40216021  DT.102840690  DT.121378792  DT.100673042  DT.95224397 
    DT.97848291  DT.100656442  DT.40105997  DT.100656444  DT.121378798  DT.92456071  DT.121378778  DT.121378789 
    DT.99926456  DT.100673041  DT.121378763  DT.121378786  DT.86999300  DT.87008916  DT.97777159  DT.100656439 

    Selected AceView cDNA sequences (see all 924):

    BM855369 AW951990 BM855709 BQ686967 BM842194 BQ673094 BM756572 AI342462 
    BG330760 CB150172 NM_014624 AW054848 BM854864 BE259873 BU191125 BU196716 
    BM760671 BM850677 BM818458 BQ937573 BM760349 BI862159 AA313264 BQ027490 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for S100A6 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6
    SP1:              -     -     -     -           -     -           -                                       
    SP2:                                      -     -     -           -                       -     -         
    SP3:              -     -     -     -     -     -     -           -                                       
    SP4:                    -     -     -     -     -     -           -                                       
    SP5:                                      -     -                 -                                       


    ECgene alternative splicing isoforms for S100A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S100A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTGGAT
    S100A6 Expression
    About this image


    S100A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Mesenchymal Condensate Cells Zeugopod
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Endothelial Cells Corneal Endothelium
     
     Epithelial Cells
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
    S100A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S100A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.275243
        Pathway & Disease-focused RT2 Profiler PCR Arrays including S100A6: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Estrogen Receptor Signaling in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S100A6 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a61 , 5 S100 calcium binding protein A6 (calcyclin)1, 5 93.26(n)1
    96.63(a)1
      3 (39.35 cM)5
    202001  NM_011313.21  NP_035443.11 
     906128945 
    chicken
    (Gallus gallus)
    Aves S100A61 S100 calcium binding protein A6 84.85(n)
    88.64(a)
      373951  NM_204148.1  NP_989479.1 


    ENSEMBL Gene Tree for S100A6 (if available)
    TreeFam Gene Tree for S100A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S100A6 gene
    S100A112  S100A12  S100A122  S100B2  S100A42  S100A32  S100A102  S100Z2  
    S100P2  S100A52  S100A22  S100A92  
    Selected SIMAP similar genes for S100A6 using alignment to 2 protein entries:     S10A6_HUMAN (see all proteins) (see all similar genes):
    S100B    S100A4    S100A5    S100A2    S100A1    S100P
    S100A16    S100A11    S100A12    S100Z    HRNR    S100G
    S100A3    S100A13    RPTN    S100A7A    S100A10    S100A7L2

    Find genes that share paralogs with S100A6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S100A6 (see all 72)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24806961,2
    C,F--153506765(-) AAGTGA/GGGCAG 1 -- ds50019Minor allele frequency- G:0.19NA WA CSA EA 369
    rs1920656201,2
    --153506792(+) CATCAC/TATCCC 1 -- ds50010--------
    rs753363511,2
    C,F--153506892(+) GAGGGG/ACATCT 1 -- ds50011Minor allele frequency- A:0.09NA 120
    rs119731,2
    C,F--153507105(+) GTACAA/TTTACC 1 -- ut313Minor allele frequency- T:0.03MN CSA WA 213
    rs1493911681,2
    C--153507165(+) CCCTAA/TTTATT 1 -- ut310--------
    rs22282931,2,,4
    C,F,H--153507176(-) CAAGGG/ACTGAA 2 /D /G mis1 ese314Minor allele frequency- A:0.02MN NS EA NA WA 6256
    rs1487422161,2
    C,F--153507255(+) GTCCTT/CGTTCC 2 /K /E mis12Minor allele frequency- C:0.00NA EU 5873
    rs2012116211,2
    C--153507261(+) GTTCCG/AGTCCA 2 /R /W mis11Minor allele frequency- A:0.00EU 1323
    rs1817878151,2
    C--153507341(+) CAGTGA/GTGATG 1 -- int10--------
    rs2015779731,2
    C--153507349(+) ATGACA/CACCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for S100A6 (153507075 - 153508720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for S100A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831603CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A6
    DNA2.0 Custom Variant and Variant Library Synthesis for S100A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114110    OMIM disorders: --

    7 diseases for S100A6:    
    About MalaCards
    cutaneous ganglioneuroma    uterine corpus cancer    spinocerebellar degeneration    renovascular hypertension
    endometrial carcinoma    pancreatic cancer    amyotrophic lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for S100A6:
    Cutaneous ganglioneuroma

    Find genes that share disorders with S100A6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for S100A6 gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ehrlich ascites tumor 57.4 10 16340196 (3), 8645294 (2), 1999197 (2), 7584597 (1) (see all 5)
    endometrial cancer 56.3 21 15001645 (6), 15589577 (4), 15866121 (3), 12770752 (2) (see all 7)
    tumors 43.8 123 18753141 (7), 18201235 (5), 18620780 (5), 11389093 (4) (see all 45)
    nevi melanocytic 41.4 5 12748257 (3), 11401666 (1), 18201235 (1)
    melanoma 35.5 39 9925766 (5), 12748257 (4), 1737392 (3), 9291441 (3) (see all 15)
    breast carcinoma 32.9 1 16168121 (1)
    breast cancer 31.9 12 10517668 (3), 11267940 (2), 15720411 (2), 15976005 (2) (see all 5)
    cancer 30.9 48 14519093 (3), 19062716 (3), 15720411 (2), 19888321 (2) (see all 27)
    malignant peripheral nerve sheath tumors 30.8 1 18201235 (1)
    adenocarcinoma 30 32 10656447 (5), 10952782 (5), 19712129 (5), 12239456 (4) (see all 8)

    Genetic Association Database (GAD): S100A6
    Human Genome Epidemiology (HuGE) Navigator: S100A6 (2 documents)

    Export disorders for S100A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S100A6 gene, integrated from 10 sources (see all 289):
    (articles sorted by number of sources associating them with S100A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (PubMed id 19724273)1, 2, 9 Nedjadi T.... Costello E. (Br. J. Cancer 2009)
    2. Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. (PubMed id 12601007)1, 2, 9 Tomas A. and Moss S.E. (J. Biol. Chem. 2003)
    3. Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. (PubMed id 11937060)1, 2, 9 Otterbein L.R....Dominguez R. (Structure 2002)
    4. Calcyclin and calvasculin exist in human platelets. (PubMed id 1482346)1, 2, 9 Tomida Y.... Hidaka H. (Biochem. Biophys. Res. Commun. 1992)
    5. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PubMed id 20188096)1, 2 Shimamoto S.... Kobayashi R. (FEBS Lett. 2010)
    6. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. (PubMed id 12746458)1, 2 Nowotny M....Kuznicki J. (J. Biol. Chem. 2003)
    10. Identification of a cell cycle-dependent gene product as a sialic acid-binding protein. (PubMed id 2775283)1, 2 Gabius H.J....Kratzin H. (Biochem. Biophys. Res. Commun. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6277 HGNC: 10496 AceView: S100A6 Ensembl:ENSG00000197956 euGenes: HUgn6277
    ECgene: S100A6 H-InvDB: S100A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S100A6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S100A6 gene:
    Search GeneIP for patents involving S100A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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