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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

S100A6 Gene

protein-coding GIFtS: 60
GCID: GC01M153507

S100 calcium binding protein A6

(Previous names: S100 calcium-binding protein A6 (calcyclin), S100 calcium...)
(Previous symbol: CACY)

Explore 79 diseases affiliated with
S100A6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
S100 Calcium Binding Protein A6¹ ²		MLN 4² ³
CACY¹ ² ³ ⁵		S100 Calcium Binding Protein A6 (Calcyclin)¹
PRA¹ ² ³		5B10²
2A9¹ ²		Calcyclin³
CABP¹ ²		Protein S100-A6²
S100 Calcium-Binding Protein A6 (Calcyclin)¹ ²		Calcyclin³
Growth Factor-Inducible Protein 2A9² ³		S100 Calcium-Binding Protein A6³
Prolactin Receptor-Associated Protein² ³

External Ids:	HGNC: 10496¹	Entrez Gene: 6277²	Ensembl: ENSG00000197956⁷	OMIM: 114110⁵	UniProtKB: P06703³

Export aliases for S100A6 gene to outside databases

Previous GC identifers: GC01M151323 GC01M149289 GC01M150334 GC01M150775 GC01M150320 GC01M151774 GC01M124870

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S100A6:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding

motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the

regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at

least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of

Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and

altered expression of this gene have been implicated in melanoma. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703

Function: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by

interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell

motility. Binds 2 calcium ions. Calcium binding is cooperative

Gene Wiki entry for S100A6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the S100A6 gene promoter:
AML1a ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100A6 promoter sequence

Search SABiosciences Chromatin IP Primers for S100A6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

S100A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A6 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M153507: view genomic region (about GC identifiers)

Start:	153,507,075 bp from pter	End:	153,508,720 bp from pter
Size:	1,646 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703 (See protein sequence)

Recommended Name: Protein S100-A6

Size: 90 amino acids; 10180 Da

Subunit: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP (By similarity). Interacts with ANXA2

and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is

phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain.

Interacts with tropomyosin. Interacts with FKBP4. Interacts with CACYBP in a calcium-dependent manner (By similarity)

Subcellular location: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side

Miscellaneous: This protein co-purified with the prolactin receptor

4 PDB 3D structures from and Proteopedia for S100A6:

1K8U (3D)

1K96 (3D)

1K9K (3D)

1K9P (3D)

Secondary accessions: D3DV39 Q5RHS4

Explore the universe of human proteins at neXtProt for S100A6: NX_P06703

Post-translational modifications:

The N-terminus is blocked¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06703

S100A6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055439.1

ENSEMBL proteins:

ENSP00000357708 ENSP00000357709

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for S100A6
	Uscn Proteins for S100A6

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	10913138
GO:0005634	nucleus	IDA	10913138
GO:0005635	nuclear envelope	NAS	12577318
GO:0005737	cytoplasm	TAS	16130169
GO:0005829	cytosol	IDA	19724273

S100A6 for ontologies About GeneDecksing

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	GenScript Custom Assay Services for S100A6
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	Uscn ELISAs and CLIAs for S100A6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

S100A6 for domains About GeneDecksing

5 InterPro domains/families:

IPR018247 EF_Hand_1_Ca_BS

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR013787 S100_Ca-bd_sub

IPR001751 S100/CaBP-9k_CS

Graphical View of Domain Structure for InterPro Entry P06703

ProtoNet protein and cluster: P06703

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S10A6_HUMAN, P06703

Function: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by

interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell

motility. Binds 2 calcium ions. Calcium binding is cooperative

Induction: Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth

factors and overexpressed in acute myeloid leukemias

Genatlas biochemistry entry for S100A6:

S100 calcium binding protein A6,10.2kDa,epidermal differentiation complex

miRNA Products:		OriGene 3'-UTR Clone: S100A6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat S100A6
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S100A6 (see all 7) OriGene shRNA RFP: S100A6 OriGene siRNA: S100A6
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for S100A6
		Search LifeMap BioReagents cell lines for S100A6

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for S100A6

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	12577318
GO:0005515	protein binding	IPI	10913138
GO:0005523	tropomyosin binding	IDA	19724273
GO:0008270	zinc ion binding	IEA	--
GO:0015075	ion transmembrane transporter activity	IEA	--

S100A6 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Prostaglandin Synthesis and Regulation

Prostaglandin Synthesis and Regulation

1.00

1 BioSystems Pathway for S100A6

Prostaglandin Synthesis and Regulation

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for S100A6

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/19 Interacting proteins for S100A6 (P06703^{1, 2, 3} ENSP00000357708⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FKBP4	Q02790²^,³, ENSP00000001008⁴	MINT-7710442 MINT-7710387 MINT-7710488 I2D: score=1 STRING: ENSP00000001008
MDM2	Q00987²^,³, ENSP00000417281⁴	MINT-7905130 MINT-7905256 I2D: score=2 STRING: ENSP00000417281
TP53	P04637²^,³, ENSP00000269305⁴	MINT-7905207 I2D: score=1 STRING: ENSP00000269305
KPNA2	P52292²^,³, ENSP00000332455⁴	MINT-8044928 MINT-8045257 MINT-8044941 I2D: score=1 STRING: ENSP00000332455
S100B	P04271¹^,³, ENSP00000291700⁴	EBI-352877,EBI-458391 I2D: score=4 STRING: ENSP00000291700

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	16130169
GO:0007409	axonogenesis	NAS	12152788
GO:0034220	ion transmembrane transport	--	--
GO:0048146	positive regulation of fibroblast proliferation	NAS	12577318

S100A6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

S100A6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for S100A6
10/28 Novoseek chemical compound relationships for S100A6 gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	62.7	63	11389093 (3), 11830547 (3), 19499404 (3), 14682477 (2) (see all 34)
17beta-hydroxysteroid	59	3	12829805 (1), 15731358 (1), 12780745 (1)
calcium	47.4	77	9578461 (4), 2358072 (3), 1467312 (3), 7645757 (2) (see all 36)
progestin	38	16	10517668 (6), 14519093 (2), 15657363 (1)
glyceraldehyde 3-phosphate	35.3	6	7584597 (2), 16220529 (1), 1999197 (1)
estrogen	28.3	9	11918216 (2), 18996480 (1), 16006726 (1), 19367380 (1) (see all 7)
progestins	27.3	1	14519093 (1)
steroid	26.6	6	8808831 (2), 1733083 (1), 1320051 (1), 18064567 (1) (see all 5)
bapta	25.3	3	12810055 (2), 17466273 (1)
retinoic acid	14.3	1	1727370 (1)

Search CenterWatch for drugs/clinical trials and news about S100A6 / S10A6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for S100A6 gene:

NM_014624.3

Unigene Cluster for S100A6:

S100 calcium binding protein A6

Hs.275243 [show with all ESTs]

Unigene Representative Sequence: BM904612

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000496817 ENST00000368719(uc001fbw.1) ENST00000368720 ENST00000462776

ENST00000462951

miRNA Products:		OriGene 3'-UTR Clone: S100A6 Browse OriGene MicroRNA Expression Plasmids
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S100A6 (see all 7) OriGene shRNA RFP: S100A6 OriGene siRNA: S100A6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat S100A6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: S100A6 (NM_014624)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A6

Additional cDNA sequence:

AK312088.1 BC001431.2 BC009017.1 BT006965.1

24/27 DOTS entries (see all 27):

DT.99926466 DT.92456063 DT.97856358 DT.40216021 DT.102840690 DT.121378792 DT.100673042 DT.95224397

DT.97848291 DT.100656442 DT.40105997 DT.100656444 DT.121378798 DT.92456071 DT.121378778 DT.121378789

DT.99926456 DT.100673041 DT.121378763 DT.121378786 DT.86999300 DT.87008916 DT.97777159 DT.100656439

24/924 AceView cDNA sequences (see all 924):

BM788624 AW152644 AI610890 AI348494 AW297172 BM840657 BQ889282 BM829994

BU527243 AA313911 CB105481 BM851487 F36681 BU185423 AI805396 BM856107

BE390942 BU527023 BU069415 AI911854 BM761760 AI571338 AW269457 BE620498

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for S100A6 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	·	5d	·	5e	^	6
SP1:					-		-		-		-				-		-				-
SP2:													-		-		-				-								-		-
SP3:					-		-		-		-		-		-		-				-
SP4:							-		-		-		-		-		-				-
SP5:													-		-						-

ECgene alternative splicing isoforms for S100A6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

S100A6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCCTGGAT

About this image

S100A6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Mesenchymal Condensate Cells

Bone, Cartilage

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16)

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

See S100A6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100A6

SOURCE GeneReport for Unigene cluster: Hs.275243

SABiosciences Expression via Pathway-Focused PCR Arrays including S100A6:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Neurogenesis in human mouse rat

Growth Factors in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100A6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A6

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for S100A6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for S100A6 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	S100A6¹	S100 calcium binding protein A6	84.85(n) 88.64(a)		373951 NM_204148.1 NP_989479.1
zebrafish (Danio rerio)	Actinopterygii	icn⁶ icn2⁶ (see all 4)	ictacalcin 2 (see all 4)	42(a) 40(a) (see all 4)	many ↔ many many ↔ many (see all 4)	16(25670482-25671845) 16(25726344-25730386)

ENSEMBL Gene Tree for S100A6 (if available)
TreeFam Gene Tree for S100A6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for S100A6 gene

S100A11² S100A1² S100A12² S100A8² S100B² S100A4² S100A3² S100A10²

S100Z² S100A5² S100A2² S100P² S100A9²

18/20 SIMAP similar genes for S100A6 using alignment to 1 protein entry: S10A6_HUMAN(see all similar genes):

S100B S100A4 S100A5 S100A1 S100P S100A16

S100A11 S100A12 S100Z HRNR S100G S100A13

S100A3 RPTN S100A2 S100A7A S100A10 S100A7L2

S100A6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2480696^1,2	C,F,	--	153506765(-)	`AAGTGA/GGGCAG`	1	--	ds500¹		9		NA WA CSA EA	369
rs192065620^1,2		--	153506792(+)	`CATCAC/TATCCC`	1	--	ds500¹		0	--	--	--	--
rs75336351^1,2	F,	--	153506892(+)	`GAGGGG/ACATCT`	1	--	ds500¹		1		NA	120
rs11973^1,2		--	153507105(+)	`GTACAA/TTTACC`	1	--	ut3¹		3		MN CSA WA	213
rs149391168^1,2	C,	--	153507165(+)	`CCCTAA/TTTATT`	1	--	ut3¹		0	--	--	--	--
rs2228293^1,2	C,F,H,	--	153507176(-)	`CAAGGG/ACTGAA`	2	/D /G	mis¹ ese³		14		MN NS EA NA WA	6256
rs148742216^1,2	C,F	--	153507255(+)	`GTCCTT/CGTTCC`	2	/K /E	mis¹		2		NA EU	5873
rs181787815^1,2	C,	--	153507341(+)	`CAGTGA/GTGATG`	1	--	int¹		0	--	--	--	--
rs201577973^1,2		--	153507349(+)	`ATGACA/CACCCT`	1	--	int¹		0	--	--	--	--
rs16835413^1,2	C,F,H,	--	153507512(+)	`GCATCC/TCCTAC`	1	--	int¹		14		NA NS EA CSA WA	1526

HapMap Linkage Disequilibrium report for S100A6 (153507075 - 153508720 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for S100A6: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

S100A6 for disorders           About GeneDecksing

OMIM gene information: 114110    OMIM disorders: --

20/79 diseases for S100A6 (see all 79):    About MalaCards

malignant peripheral nerve sheath tumor melanoma androgen insensitivity syndrome amyotrophic lateral sclerosis

actinic keratosis uterine corpus cancer lateral sclerosis endometrial stromal sarcoma

cutaneous ganglioneuroma anaplastic astrocytoma connective tissue disease renovascular hypertension

pilocytic astrocytoma oral squamous cell carcinoma spinocerebellar degeneration cystic fibrosis

squamous cell carcinoma sjogren's syndrome hidradenoma lupus erythematosus

10/50 Novoseek disease relationships for S100A6 gene (see all 50) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ehrlich ascites tumor	57.4	10	16340196 (3), 8645294 (2), 1999197 (2), 7584597 (1) (see all 5)
endometrial cancer	56.3	21	15001645 (6), 15589577 (4), 15866121 (3), 12770752 (2) (see all 7)
tumors	43.8	123	18753141 (7), 18201235 (5), 18620780 (5), 11389093 (4) (see all 45)
nevi melanocytic	41.4	5	12748257 (3), 11401666 (1), 18201235 (1)
melanoma	35.5	39	9925766 (5), 12748257 (4), 1737392 (3), 9291441 (3) (see all 15)
breast carcinoma	32.9	1	16168121 (1)
breast cancer	31.9	12	10517668 (3), 11267940 (2), 15720411 (2), 15976005 (2) (see all 5)
cancer	30.9	48	14519093 (3), 19062716 (3), 15720411 (2), 19888321 (2) (see all 27)
malignant peripheral nerve sheath tumors	30.8	1	18201235 (1)
adenocarcinoma	30	32	10656447 (5), 10952782 (5), 19712129 (5), 12239456 (4) (see all 8)

Human Genome Epidemiology (HuGE) Navigator: S100A6 (2 documents)

Export disorders for S100A6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for S100A6 gene, integrated from 9 sources (see all 280):
(articles sorted by number of sources associating them with S100A6)

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S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (PubMed id 19724273)^{1, 2, 9} Nedjadi T.... Costello E. (2009)
Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. (PubMed id 12601007)^{1, 2, 9} Tomas A. and Moss S.E. (2003)
Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. (PubMed id 11937060)^{1, 2, 9} Otterbein L.R....Dominguez R. (2002)
Calcyclin and calvasculin exist in human platelets. (PubMed id 1482346)^{1, 2, 9} Tomida Y.... Hidaka H. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. (PubMed id 12746458)^{1, 2} Nowotny M....Kuznicki J. (2003)
Identification of a cell cycle-dependent gene product as a sialic acid-binding protein. (PubMed id 2775283)^{1, 2} Gabius H.J....Kratzin H. (1989)
Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum. (PubMed id 2448309)^{1, 2} Murphy L.C.... Shiu R.P.C. (1988)
Structural and functional analysis of a growth-regulated gene, the human calcyclin. (PubMed id 3036810)^{1, 2} Ferrari S.... Baserga R. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6277	HGNC: 10496	AceView: S100A6	Ensembl:ENSG00000197956	euGenes: HUgn6277
ECgene: S100A6	H-InvDB: S100A6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for S100A6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for S100A6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for S100A6 gene
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S100 calcium binding protein A6

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S100A6 Gene

S100 calcium binding protein A6

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