S100A5 Gene
protein-coding GIFtS: 52
GCID: GC01M153509
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S100 calcium binding protein A5(Previous name: S100 calcium-binding protein A5 )
(Previous symbol: S100D)
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Aliases
for S100A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| S100 Calcium Binding Protein A51 2 | | S100D1 2 3 5 | | S100 Calcium-Binding Protein A51 2 3 | | Protein S100-A52 | | Protein S-100D3 |
Export aliases for S100A5 gene to outside databasesPrevious GC identifers: GC01M151325 GC01M149292 GC01M150336 GC01M150778 GC01M150322 GC01M151776 GC01M124872 |
Summaries
for S100A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for S100A5:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-bindingmotifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in theregulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include atleast 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-foldhigher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, andCu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adultbrain. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: S10A5_HUMAN, P33763Function: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1zinc ion. Calcium and copper ions compete for the same binding sites
Gene Wiki entry for S100A5
|
Genomic Views
for S100A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the S100A5 gene promoter:
AML1a ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for S100A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21S100A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153509: view genomic region
(about GC identifiers)
Start:
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153,509,623 bp from pter |
End:
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153,514,241 bp from pter |
Size:
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4,619 bases |
Orientation:
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minus strand |
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Proteins
for S100A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S10A5_HUMAN, P33763 (See
protein sequence)Recommended Name: Protein S100-A5 Size: 92 amino acids; 10744 Da
Subunit: Homodimer
Sequence caution: Sequence=CAA79472.1; Type=Erroneous initiation; Sequence=CAA79475.1; Type=Erroneous initiation;Sequence=CAA79479.1; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for S100A5:2KAX (3D)
2KAY (3D)
4DIR (3D)
Secondary accessions: Q5RHS3Explore the universe of human proteins at neXtProt for S100A5: NX_P33763
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P33763
S100A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002953.2
ENSEMBL proteins: ENSP00000357707 ENSP00000357706 ENSP00000352148
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
S100A5 for ontologies About GeneDecksing
S100A5 Antibody Products:
Assay Products for S100A5: |
Protein
Domains /
Families
for S100A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
S100A5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P33763ProtoNet protein and cluster: P33763 1 Blocks protein family: IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: S10A5_HUMAN, P33763Similarity: Belongs to the S-100 familySimilarity: Contains 2 EF-hand domains |
Function
for S100A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S10A5_HUMAN, P33763Function: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1zinc ion. Calcium and copper ions compete for the same binding sites Genatlas biochemistry entry for S100A5:S100 calcium binding protein A5,epidermal differentiation complex
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A5 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
S100A5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for S100A5:
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Pathways & Interactions
for S100A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S100A5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for S100A5 (P337632, 3 ENSP000003521484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for S100A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for S100A5
Search CenterWatch for drugs/clinical trials and news about S100A5 / S10A5
|
Transcripts
for S100A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for S100A5 gene: NM_002962.1 Unigene Cluster for S100A5: S100 calcium binding protein A5 Hs.2960 [show with all ESTs]Unigene Representative Sequence: BG2008383 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368718 ENST00000368717 ENST00000359215(uc001fbx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: S100A5 (NM_002962) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A5 |
Additional cDNA sequence: BC093955.1 BC093957.2 Z18954.1 2 DOTS entries: DT.306595 DT.92070646 10 AceView cDNA sequences: Z18954 NM_002962 AW090645 AA810909 BG208555 BG212210 BG207000 BG209078 BG201757 BG200838
GeneLoc Exon Structure
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Expression
for S100A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| S100A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See S100A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100A5
SOURCE GeneReport for Unigene cluster: Hs.2960
SABiosciences Custom PCR Arrays for S100A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat S100A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A5 |
Orthologs
for S100A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for S100A5 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for S100A5 (if available)
TreeFam Gene Tree for S100A5 (if available) |
Paralogs
for S100A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for S100A5 gene
- S100A112 S100A62 S100A12 S100A122 S100A82 S100B2 S100A42 S100A32
- S100A102 S100Z2 S100A22 S100P2 S100A92
16 SIMAP similar genes for S100A5 using alignment to 2 protein entries: S10A5_HUMAN (see all proteins):S100B S100A6 S100A4 S100A1 S100Z S100A12
S100G S100A13 HRNR S100A2 S100A11 S100A3
S100A9 S100A10 S100A8 S100P
S100A5 for paralogs About GeneDecksing
|
Genomic Variants
for S100A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for S100A5 (153509623 - 153514241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for S100A5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100A5 |
|
Disorders
/ Diseases
for S100A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
S100A5 for disorders About GeneDecksing
OMIM gene information: 176991
OMIM disorders: --
10  diseases for S100A5: About MalaCardsanaplastic astrocytoma pilocytic astrocytoma atopic dermatitis astrocytoma
craniopharyngioma cholesteatoma dermatitis meningioma
glioblastoma alzheimer's disease
4 Novoseek disease relationships for S100A5 gene About this table
Human Genome Epidemiology (HuGE) Navigator: S100A5 (1 document)
Export disorders for S100A5 gene to outside databases
|
Publications
for S100A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for S100A5 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with S100A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)1, 2, 3 Engelkamp D.... Heizmann C.W. (1993)
- Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states. (PubMed id 19536568)1, 2, 9 Bertini I....Yuan J. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. (PubMed id 10882717)1, 2 Schaefer B.W.... Cox J.A. (2000)
- Differential expression of S100 proteins in the developing human hippocampus and temporal cortex. (PubMed id 12645008)1, 9 Chan W.Y....Yew D.T. (2003)
- Restricted expression of calcium-binding protein S100A5 in human kidney. (PubMed id 11855835)1, 9 Teratani T....Nozawa R. (2002)
- Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins. (PubMed id 11510959)1, 9 Bronckart Y....Heizman C.W. (2001)
- Clustered organization of S100 genes in human and mouse. (PubMed id 9920416)1, 9 Ridinger K....Schafer B.W. (1998)
- Hippocampal atrophy as a quantitative trait in a geno me-wide association study identifying novel susceptibility genes for Alzheimer' s disease. (PubMed id 19668339)1 Potkin S.G....Macciardi F. (2009)
- Variation in genes of the epidermal differentiation c omplex in German atopic dermatitis patients. (PubMed id 19601998)1 Stemmler S....Hoffjan S. (2009)
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External Searches for S100A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing S100A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing S100A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing S100A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for S100A5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for S100A5 gene:
Search GeneIP for patents involving S100A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for S100A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | S100A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A5 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A5 |
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