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Aliases for S100A5 Gene

Aliases for S100A5 Gene

  • S100 Calcium Binding Protein A5 2 3 5
  • S100 Calcium-Binding Protein A5 2 4
  • S100D 3 4
  • Protein S100-A5 3
  • Protein S-100D 4

External Ids for S100A5 Gene

Previous HGNC Symbols for S100A5 Gene

  • S100D

Previous GeneCards Identifiers for S100A5 Gene

  • GC01M151325
  • GC01M149292
  • GC01M150336
  • GC01M150778
  • GC01M150322
  • GC01M151776
  • GC01M124872

Summaries for S100A5 Gene

Entrez Gene Summary for S100A5 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A5 Gene

S100A5 (S100 Calcium Binding Protein A5) is a Protein Coding gene. Diseases associated with S100A5 include Meningioma, Familial. GO annotations related to this gene include calcium ion binding and copper ion binding. An important paralog of this gene is S100A2.

UniProtKB/Swiss-Prot for S100A5 Gene

  • Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

Gene Wiki entry for S100A5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A5 Gene

Genomics for S100A5 Gene

Regulatory Elements for S100A5 Gene

Enhancers for S100A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G153561 2 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -23.4 -23387 8.8 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D GLIS1 NBN NR2C1 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1 CHTOP
GH01G153494 0.9 ENCODE 11.6 +47.1 47106 0.2 HDGF PKNOX1 RB1 INSM2 KLF17 ZNF2 RAD21 ZNF366 ZNF143 ZNF391 ENSG00000238279 S100A6 S100A5 S100A3 S100A4 PGLYRP4 S100A9 RNU6-160P S100A16 S100A14
GH01G153492 0.8 dbSUPER 11.6 +48.6 48554 2.1 HDAC1 CTCF CBX3 CREB3L1 RB1 MAX RAD21 ZNF143 SMC3 ZNF654 RN7SL44P ENSG00000238279 S100A6 S100A5 S100A3 S100A4 PGLYRP4 S100A9 RNU6-160P S100A1
GH01G153539 1.3 ENCODE dbSUPER 0.7 -3.4 -3357 12.0 PKNOX1 ARID4B SIN3A DMAP1 CBX5 FOS DEK SP3 SP5 JUNB S100A3 S100A16 S100A14 S100A1 S100A13 CHTOP INTS3 ENSG00000233222 ENSG00000243613 ILF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S100A5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the S100A5 gene promoter:

Genomic Location for S100A5 Gene

Chromosome:
1
Start:
153,537,147 bp from pter
End:
153,542,175 bp from pter
Size:
5,029 bases
Orientation:
Minus strand

Genomic View for S100A5 Gene

Genes around S100A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A5 Gene

Proteins for S100A5 Gene

  • Protein details for S100A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33763-S10A5_HUMAN
    Recommended name:
    Protein S100-A5
    Protein Accession:
    P33763
    Secondary Accessions:
    • Q52LE7
    • Q5RHS3

    Protein attributes for S100A5 Gene

    Size:
    92 amino acids
    Molecular mass:
    10744 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAA79472.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA79475.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA79479.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100A5 Gene

    Alternative splice isoforms for S100A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for S100A5 Gene

Post-translational modifications for S100A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A5 Gene

No data available for DME Specific Peptides for S100A5 Gene

Domains & Families for S100A5 Gene

Suggested Antigen Peptide Sequences for S100A5 Gene

Graphical View of Domain Structure for InterPro Entry

P33763

UniProtKB/Swiss-Prot:

S10A5_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A5: view

Function for S100A5 Gene

Molecular function for S100A5 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A5,epidermal differentiation complex
UniProtKB/Swiss-Prot Function:
Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

Gene Ontology (GO) - Molecular Function for S100A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IDA 19536568
GO:0005509 calcium ion binding IDA 19536568
GO:0008270 zinc ion binding IDA 19536568
GO:0042803 protein homodimerization activity IPI 19536568
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A5: view
genes like me logo Genes that share phenotypes with S100A5: view

Animal Models for S100A5 Gene

MGI Knock Outs for S100A5:

Animal Model Products

CRISPR Products

miRNA for S100A5 Gene

miRTarBase miRNAs that target S100A5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A5 Gene

Localization for S100A5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for S100A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12118070
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with S100A5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for S100A5 Gene

Pathways & Interactions for S100A5 Gene

SuperPathways for S100A5 Gene

No Data Available

Interacting Proteins for S100A5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357706%0d%0a9606.ENSP00000264487%0d%0a9606.ENSP00000370227%0d%0a
Selected Interacting proteins: P33763-S10A5_HUMAN ENSP00000357706 for S100A5 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for S100A5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for S100A5 Gene

Drugs & Compounds for S100A5 Gene

No Compound Related Data Available

Transcripts for S100A5 Gene

mRNA/cDNA for S100A5 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A5 Gene

S100 calcium binding protein A5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A5 Gene

No ASD Table

Relevant External Links for S100A5 Gene

GeneLoc Exon Structure for
S100A5
ECgene alternative splicing isoforms for
S100A5

Expression for S100A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A5 Gene

mRNA differential expression in normal tissues according to GTEx for S100A5 Gene

This gene is overexpressed in Thyroid (x7.0) and Whole Blood (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of S100A5 Gene:

S100A5

SOURCE GeneReport for Unigene cluster for S100A5 Gene:

Hs.2960

Evidence on tissue expression from TISSUES for S100A5 Gene

  • Nervous system(4.3)
  • Kidney(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with S100A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A5 Gene

Orthologs for S100A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A5 34 35
  • 99.28 (n)
mouse
(Mus musculus)
Mammalia S100a5 34 16 35
  • 90.94 (n)
cow
(Bos Taurus)
Mammalia S100A5 34 35
  • 90.58 (n)
rat
(Rattus norvegicus)
Mammalia S100a5 34
  • 90.58 (n)
dog
(Canis familiaris)
Mammalia S100A5 34 35
  • 88.77 (n)
Species where no ortholog for S100A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A5 Gene

ENSEMBL:
Gene Tree for S100A5 (if available)
TreeFam:
Gene Tree for S100A5 (if available)

Paralogs for S100A5 Gene

(16) SIMAP similar genes for S100A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with S100A5: view

Variants for S100A5 Gene

Sequence variations from dbSNP and Humsavar for S100A5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000286018 -- 153,540,503(+) AAAAG(A/G)CCCTG intron-variant, utr-variant-5-prime
rs1001411945 -- 153,540,886(+) TAAGG(A/G)CCTGG intron-variant, utr-variant-5-prime
rs1002875101 -- 153,542,905(+) TTCTG(A/C)GGTCC intron-variant, upstream-variant-2KB
rs1003085771 -- 153,539,607(+) TGTTT(A/G)CAAGT intron-variant
rs1003199194 -- 153,537,725(+) CAATC(A/C)TCTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S100A5 Gene

Variant ID Type Subtype PubMed ID
esv3587584 CNV gain 21293372
esv3587591 CNV gain 21293372
nsv1002705 CNV gain 25217958
nsv831603 CNV gain 17160897

Variation tolerance for S100A5 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A5 Gene

Disorders for S100A5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100A5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
meningioma, familial
  • meningioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A5

Genetic Association Database (GAD)
S100A5
Human Genome Epidemiology (HuGE) Navigator
S100A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A5
genes like me logo Genes that share disorders with S100A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A5 Gene

Publications for S100A5 Gene

  1. Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states. (PMID: 19536568) Bertini I. … Yuan J. (J. Biol. Inorg. Chem. 2009) 3 4 22 64
  2. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PMID: 8341667) Engelkamp D. … Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  3. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 46 64
  4. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for S100A5 Gene

Sources for S100A5 Gene

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