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Aliases for S100A5 Gene

Aliases for S100A5 Gene

  • S100 Calcium Binding Protein A5 2 3
  • S100 Calcium-Binding Protein A5 2 3 4
  • S100D 3 4 6
  • Protein S100-A5 3
  • Protein S-100D 4

External Ids for S100A5 Gene

Previous HGNC Symbols for S100A5 Gene

  • S100D

Previous GeneCards Identifiers for S100A5 Gene

  • GC01M151325
  • GC01M149292
  • GC01M150336
  • GC01M150778
  • GC01M150322
  • GC01M151776
  • GC01M124872

Summaries for S100A5 Gene

Entrez Gene Summary for S100A5 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A5 Gene

S100A5 (S100 Calcium Binding Protein A5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and copper ion binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A5 Gene

  • Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

Gene Wiki entry for S100A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A5 Gene

Genomics for S100A5 Gene

Regulatory Elements for S100A5 Gene

Transcription factor binding sites by QIAGEN in the S100A5 gene promoter:

Genomic Location for S100A5 Gene

Start:
153,537,147 bp from pter
End:
153,543,296 bp from pter
Size:
6,150 bases
Orientation:
Minus strand

Genomic View for S100A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A5 Gene

Proteins for S100A5 Gene

  • Protein details for S100A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33763-S10A5_HUMAN
    Recommended name:
    Protein S100-A5
    Protein Accession:
    P33763
    Secondary Accessions:
    • Q52LE7
    • Q5RHS3

    Protein attributes for S100A5 Gene

    Size:
    92 amino acids
    Molecular mass:
    10744 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAA79472.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA79475.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA79479.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100A5 Gene

    Alternative splice isoforms for S100A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for S100A5 Gene

Proteomics data for S100A5 Gene at MOPED

Post-translational modifications for S100A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A5 Gene

Domains for S100A5 Gene

Gene Families for S100A5 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

Suggested Antigen Peptide Sequences for S100A5 Gene

Graphical View of Domain Structure for InterPro Entry

P33763

UniProtKB/Swiss-Prot:

S10A5_HUMAN :
  • P33763
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A5: view

Function for S100A5 Gene

Molecular function for S100A5 Gene

GENATLAS Biochemistry: S100 calcium binding protein A5,epidermal differentiation complex
UniProtKB/Swiss-Prot Function: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

Gene Ontology (GO) - Molecular Function for S100A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IDA 19536568
GO:0005509 calcium ion binding IDA 19536568
GO:0008270 zinc ion binding IDA 19536568
GO:0042803 protein homodimerization activity IPI 19536568
genes like me logo Genes that share ontologies with S100A5: view

Phenotypes for S100A5 Gene

genes like me logo Genes that share phenotypes with S100A5: view

miRNA for S100A5 Gene

miRTarBase miRNAs that target S100A5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for S100A5 Gene

Localization for S100A5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A5 Gene COMPARTMENTS Subcellular localization image for S100A5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for S100A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12118070
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with S100A5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for S100A5 Gene

Pathways for S100A5 Gene

SuperPathways for S100A5 Gene

No Data Available

Interacting Proteins for S100A5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357706%0d%0a9606.ENSP00000370227%0d%0a9606.ENSP00000264487%0d%0a
Selected Interacting proteins: P33763-S10A5_HUMAN ENSP00000357706 for S100A5 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for S100A5 Gene

None

No data available for Pathways by source for S100A5 Gene

Transcripts for S100A5 Gene

mRNA/cDNA for S100A5 Gene

(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A5 Gene

S100 calcium binding protein A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A5 Gene

No ASD Table

Relevant External Links for S100A5 Gene

GeneLoc Exon Structure for
S100A5
ECgene alternative splicing isoforms for
S100A5

Expression for S100A5 Gene

mRNA expression in normal human tissues for S100A5 Gene

mRNA differential expression in normal tissues according to GTEx for S100A5 Gene

This gene is overexpressed in Thyroid (7.0) and Whole Blood (5.2).

SOURCE GeneReport for Unigene cluster for S100A5 Gene Hs.2960

genes like me logo Genes that share expressions with S100A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for S100A5 Gene

Orthologs for S100A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A5 35
  • 99.28 (n)
  • 98.91 (a)
S100A5 36
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100A5 35
  • 90.58 (n)
  • 95.65 (a)
S100A5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A5 35
  • 88.77 (n)
  • 91.3 (a)
S100A5 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100a5 35
  • 90.94 (n)
  • 94.57 (a)
S100a5 16
S100a5 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a5 35
  • 90.58 (n)
  • 94.57 (a)
Species with no ortholog for S100A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A5 Gene

ENSEMBL:
Gene Tree for S100A5 (if available)
TreeFam:
Gene Tree for S100A5 (if available)

Paralogs for S100A5 Gene

Selected SIMAP similar genes for S100A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with S100A5: view

Variants for S100A5 Gene

Sequence variations from dbSNP and Humsavar for S100A5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15262 -- 153,543,925(-) TCTTG(G/T)GGAAA upstream-variant-2KB
rs472778 -- 153,538,628(-) ATGGG(C/T)AGGGG intron-variant
rs743687 -- 153,543,049(-) TCAGG(C/G)AGGGC upstream-variant-2KB, intron-variant
rs762829 -- 153,542,422(-) GGGAG(C/G)GCCCT upstream-variant-2KB, intron-variant
rs762830 -- 153,542,416(-) GCCCT(C/T)CCTGG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A5 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Relevant External Links for S100A5 Gene

HapMap Linkage Disequilibrium report
S100A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A5 Gene

Disorders for S100A5 Gene

(4) Novoseek inferred disease relationships for S100A5 Gene

Disease -log(P) Hits PubMed IDs
anaplastic astrocytoma 58.4 1
meningioma 51.4 7
glioblastoma 40.1 1
tumors 0 3

Relevant External Links for S100A5

Genetic Association Database (GAD)
S100A5
Human Genome Epidemiology (HuGE) Navigator
S100A5
genes like me logo Genes that share disorders with S100A5: view

No data available for UniProtKB/Swiss-Prot for S100A5 Gene

Publications for S100A5 Gene

  1. Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states. (PMID: 19536568) Bertini I. … Yuan J. (J. Biol. Inorg. Chem. 2009) 3 4 23
  2. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PMID: 8341667) Engelkamp D. … Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4
  3. Clustered organization of S100 genes in human and mouse. (PMID: 9920416) Ridinger K. … SchAofer B.W. (Biochim. Biophys. Acta 1998) 3 23
  4. Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins. (PMID: 11510959) Bronckart Y. … Heizman C.W. (Histol. Histopathol. 2001) 3 23
  5. Restricted expression of calcium-binding protein S100A5 in human kidney. (PMID: 11855835) Teratani T. … Nozawa R. (Biochem. Biophys. Res. Commun. 2002) 3 23

Products for S100A5 Gene

Sources for S100A5 Gene

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