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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100A4 Gene

protein-coding   GIFtS: 63
GCID: GC01M153517

S100 calcium binding protein A4

(Previous names: S100 calcium-binding protein A4 (calcium protein, calvasculin,...)
(Previous symbols: MTS1, CAPL)
 Explore 76 diseases affiliated with
S100A4 via
MalaCards
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 Human Malady Compendium 
Biological research products
for S100A4    

Aliases
for S100A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
S100 Calcium Binding Protein A41 2     Protein Mts12 3
CAPL1 2 3 5     S100 Calcium Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin,
Murine Placental Homolog)1
MTS11 2 3     Fibroblast-Specific Protein-12
18A21 2     Leukemia Multidrug Resistance Associated Protein2
42A1 2     Malignant Transformation Suppression 12
FSP11 2     Protein S100-A42
P9KA1 2     Calvasculin3
PEL981 2     Metastasin3
S100 Calcium-Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin,
Murine Placental Homolog)1 2
     S100 Calcium-Binding Protein A43
Placental Calcium-Binding Protein2 3     

External Ids:    HGNC: 104941   Entrez Gene: 62752   Ensembl: ENSG000001961547   OMIM: 1142105   UniProtKB: P264473   

Export aliases for S100A4 gene to outside databases

Previous GC identifers: GC01M151332 GC01M149298 GC01M150343 GC01M150784 GC01M150585 GC01M150330 GC01M151783 GC01M124879


Summaries
for S100A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for S100A4:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at
least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion,
and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in
tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided
by RefSeq, Jul 2008)

Gene Wiki entry for S100A4


Genomic Views
for S100A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100A4 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for S100A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q12-q22

S100A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153517:  view genomic region     (about GC identifiers)

Start:
 153,516,089 bp from pter      End:
 153,522,612 bp from pter
Size:
 6,524 bases      Orientation:
 minus strand

Proteins
for S100A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447 (See protein sequence)
Recommended Name: Protein S100-A4  
Size: 101 amino acids; 11729 Da
Subunit: Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode
6/10 PDB 3D structures from and Proteopedia for S100A4 (see all 10):
1M31 (3D)        2LNK (3D)        2Q91 (3D)        3C1V (3D)        3CGA (3D)        3KO0 (3D)    
Secondary accessions: A8K7R8 D3DV46 Q6ICP8

Explore the universe of human proteins at neXtProt for S100A4: NX_P26447

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26447

    • S100A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002952.1  NP_062427.1  

    ENSEMBL proteins: 
     ENSP00000357704   ENSP00000346294   ENSP00000357705   ENSP00000357703  

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    Sino Biological Recombinant Protein for S100A4
    ProSpec Recombinant Protein for S100A4
    Uscn Proteins for S100A4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15033494
    GO:0043005neuron projection IEA--
    GO:0048471perinuclear region of cytoplasm IDA15033494


    S100A4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for S100A4

    Protein Domains /
    Families
    for S100A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    S100A4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR013787 S100_Ca-bd_sub
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry P26447

    ProtoNet protein and cluster: P26447

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Function
    for S100A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for S100A4:
    S100 calcium binding protein A4,murine placental homolog,epidermal differentiation complex,possessing
    metastasis-inducing capabilities,involved in the regulation of cell cycle progression,modulating intercellular
    adhesion,and invasive and metastatic properties of cancer cells

    miRNA
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15479433
    GO:0042802identical protein binding IEA--
    GO:0048306calcium-dependent protein binding IEA--
    GO:0050786RAGE receptor binding IPI15033494


    S100A4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for S100A4: S100a4tm1.1Abres S100a4tm1Amba
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for S100a4):
     cellular  immune system  mortality/aging  normal  tumorigenesis 

    S100A4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for S100A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/114 Interacting proteins for S100A4 (P264472, 3 ENSP000003462944) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AREGP155142, 3MINT-7256618 MINT-7256636 MINT-7256485 MINT-7256567 I2D: score=1 
    TP53P046372, 3, ENSP000002693054MINT-7905196 MINT-7256502 MINT-7905358 I2D: score=4 STRING: ENSP00000269305
    MDM2Q009872, 3, ENSP000004172814MINT-7905104 MINT-7905247 MINT-7905376 I2D: score=2 STRING: ENSP00000417281
    BTCP350702, 3MINT-7256512 MINT-7256593 I2D: score=1 
    HBEGFQ990752, 3, ENSP000002309904MINT-7256494 I2D: score=1 STRING: ENSP00000230990
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition TAS14679171
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IDA15033494


    S100A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for S100A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for S100A4

    1 HMDB Compound for S100A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for S100A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TrifluoperazineTrifluoperazin (see all 13)117-89-5targetinhibitor20421509 10592235

    10/11 Novoseek chemical compound relationships for S100A4 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 46.6 5 7536040 (1), 10091942 (1), 19703228 (1)
    matrigel 28.9 3 11029520 (2)
    calcium 25.2 71 12756252 (5), 20083144 (5), 11914069 (4), 15856021 (4) (see all 22)
    estrogen 11 8 16489073 (2), 15956747 (1), 17673926 (1), 19834055 (1) (see all 5)
    progesterone 6.02 5 17673926 (1), 19834055 (1), 19056847 (1)
    oligonucleotide 0 1 16367903 (1)
    nacl 0 2 11108967 (1), 17200116 (1)
    steroid 0 1 14598884 (1)
    tyrosine 0 3 18435928 (1), 11836260 (1)
    phosphatidylserine 0 1 17638890 (1)

    Search CenterWatch for drugs/clinical trials and news about S100A4 / S10A4 

    Transcripts
    for S100A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for S100A4 gene (2 alternative transcripts): 
    NM_002961.2  NM_019554.2  

    Unigene Cluster for S100A4:

    S100 calcium binding protein A4
    Hs.654444  [show with all ESTs]
    Unigene Representative Sequence: BQ945534
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368715 ENST00000481009 ENST00000354332(uc001fby.3) ENST00000468373
    ENST00000368716(uc001fbz.3) ENST00000368714

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK292083.1 AY754741.1 AY762982.1 BC000838.1 BC016300.1 BC024974.1 CR450345.1 M80563.1 

    17 DOTS entries:

    DT.87017506  DT.95077872  DT.100819070  DT.95077836  DT.97859764  DT.95077834  DT.100697627  DT.101984896 
    DT.121326675  DT.100059942  DT.100697637  DT.121326679  DT.121326682  DT.121326683  DT.65285093  DT.212995 
    DT.97800192 

    24/388 AceView cDNA sequences (see all 388):

    AJ713270 AA872450 H58281 AI168075 BM764773 BU626248 BG034589 CB109749 
    BU733135 NM_002961 W94732 CR542163 BM741613 CB109338 AI160872 BM761287 
    NM_002960 BM126466 AA503538 BM694264 BM687134 BM754955 AI435831 BC012893 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for S100A4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                    -                 -     -           -                                 
    SP2:                    -           -     -     -           -                                 
    SP3:                    -     -     -     -     -           -                                 
    SP4:                    -     -     -     -     -                                             
    SP5:                                -     -     -           -                                 


    ECgene alternative splicing isoforms for S100A4

    Expression
    for S100A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTGTAACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    S100A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone

    See S100A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100A4

    SOURCE GeneReport for Unigene cluster: Hs.654444

    UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including S100A4: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for S100A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for S100A4 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008582921 protein S100-A4-like 78.88(n)
    80.2(a)    		   100858292  XM_003642630.1  XP_003642678.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii icn1 ictacalcin 60.92(n)
    57.47(a)    		   336655  NM_212761.2  NP_997926.1 


    ENSEMBL Gene Tree for S100A4 (if available)
    TreeFam Gene Tree for S100A4 (if available) 

    Paralogs
    for S100A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S100A4 gene
    S100A112  S100A62  S100A12  S100A122  S100A82  S100B2  S100A32  S100A102  
    S100Z2  S100A22  S100P2  S100A52  S100A92  
    18/20 SIMAP similar genes for S100A4 using alignment to 1 protein entry:     S10A4_HUMAN(see all similar genes):
    S100A1    S100A6    S100B    S100A11    S100A5    S100A12
    S100A13    S100A16    S100P    S100Z    S100A14    S100A3
    S100A2    S100A9    S100A10    RPTN    S100G    S100A7A

    S100A4 for paralogs           About GeneDecksing



    Genomic Variants
    for S100A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/73 NCBI SNPs in S100A4 are shown (see all 73)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs114861371,2
    		C,F,--124878882(+) GTCAAC/TGTCAG 2 -- ds50015Minor allele frequency- T:0.15NA WA CSA 125
    rs114861381,2
    		F,--124878886(+) ACGTCA/CGCACT 2 -- ds50011Minor allele frequency- C:0.04WA 118
    rs7303471,2
    		C,F,A,H,--124879080(-) CTCCCA/CCCTCT 2 -- ds500114Minor allele frequency- C:0.21EA NA NS WA CSA 1248
    rs730263411,2
    		C,F,--124879202(+) GTGCAC/AACACA 2 -- ds50014Minor allele frequency- A:0.15WA CSA 125
    rs285871711,2
    		C,--124879319(+) GTCCCC/TAACCC 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1134436971,2
    		F,--124879414(+) AGGAGC/GCAGGG 2 -- ut312Minor allele frequency- G:0.07CSA WA 122
    rs285157591,2
    		C--124879672(+) GAGAAA/GAGGCT 2 -- int1 trp30--------
    rs793993291,2
    		C,F,--124879993(+) CGTCTG/ACAGGC 2 -- int15Minor allele frequency- A:0.22WA CSA NA 244
    rs1120441641,2
    		C--124880547(+) GGATCA/TGGGAG 2 -- spa11Minor allele frequency- T:0.00CSA 1
    rs1112514381,2
    		F--124880644(+) CTTGGC/TGAGAC 2 -- int12Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for S100A4 (153516089 - 153522612 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for S100A4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for S100A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    S100A4 for disorders           About GeneDecksing

    OMIM gene information: 114210    OMIM disorders: --

    20/76 diseases for S100A4 (see all 76):    About MalaCards
    non-small cell lung carcinoma    squamous cell carcinoma    bile duct adenocarcinoma    leukemia
    ureteral obstruction    laryngeal squamous cell carcinoma    pilocytic astrocytoma    oral squamous cell carcinoma
    carcinoma    esophageal squamous cell carcinoma    adenocarcinoma    pancreatic ductal adenocarcinoma
    lung squamous cell carcinoma    thyroid carcinoma    goiter    atopic dermatitis
    papillary thyroid carcinoma    anaplastic astrocytoma    rheumatoid arthritis    papillary carcinoma

    2 diseases from the University of Copenhagen DISEASES database for S100A4:
    Carcinoma     Breast cancer

    10/48 Novoseek disease relationships for S100A4 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 67.6 218 19820999 (9), 16265347 (7), 18360353 (6), 17101323 (6) (see all 91)
    tumors 52.5 184 20442771 (7), 17673926 (5), 12445462 (5), 7794250 (4) (see all 80)
    cancer 51.1 101 19703228 (6), 9703888 (5), 18803290 (3), 19808905 (3) (see all 55)
    carcinoma 49.5 47 10738249 (4), 11875708 (4), 17276942 (4), 19194111 (3) (see all 22)
    adenocarcinoma 46.5 39 16685438 (6), 11029520 (5), 12239456 (4), 9815629 (4) (see all 12)
    breast cancer 42.4 50 18771601 (3), 8824556 (3), 17565747 (3), 16489073 (3) (see all 23)
    primary tumor 41.2 12 16489073 (2), 11839590 (2), 19365673 (1), 11836260 (1) (see all 7)
    thyroid carcinoma anaplastic 40.5 5 16551737 (2), 16265347 (1)
    pancreatic cancer 37.7 21 16865243 (4), 18350635 (4), 19799859 (3), 19653048 (3) (see all 7)
    pancreatic carcinoma 37.4 10 11786397 (6), 19653048 (1), 12874021 (1)

    Human Genome Epidemiology (HuGE) Navigator: S100A4 (2 documents)
    Tumor Gene Database (TGDB): S100A4

    Export disorders for S100A4 gene to outside databases

    Publications
    for S100A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100A4 gene, integrated from 9 sources (see all 358):
    (articles sorted by number of sources associating them with S100A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis- associated protein S100A4 (Mts1). (PubMed id 11836260)1, 2, 9 Kriajevska M.... Lukanidin E. (2002)
    2. Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy. (PubMed id 12379109)1, 2, 9 Vallely K.M....Weber D.J. (2002)
    3. Calcyclin and calvasculin exist in human platelets. (PubMed id 1482346)1, 2, 9 Tomida Y.... Hidaka H. (1992)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)1, 2 Engelkamp D.... Heizmann C.W. (1993)
    7. Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences. (PubMed id 1329089)1, 2 Tulchinsky E.M.... Lukanidin E. (1992)
    8. S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. (PubMed id 1384693)1, 2 Engelkamp D.... Heizmann C.W. (1992)
    9. Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation. (PubMed id 3155863)1, 3 Stoler A. and Bouck N. (1985)
    10. Metastasis-associated protein S100A4: spotlight on its role in cell migration. (PubMed id 17504119)1, 9 Tarabykina S....Kriajevska M. (2007)

    External Searches for S100A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing S100A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6275 HGNC: 10494 AceView: S100A3andS100A4 Ensembl:ENSG00000196154 euGenes: HUgn6275
    ECgene: S100A4 H-InvDB: S100A4

    Other Databases showing S100A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing S100A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100A4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for S100A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for S100A4 gene:
    Search GeneIP for patents involving S100A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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