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S100A4 Gene

protein-coding GIFtS: 62

GC01M151783

S100 calcium binding protein A4
(Previous names: S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MTS1, CAPL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
18A2 ^¹, ²
42A ^¹, ²
CAPL ^², ³, ⁵
Calvasculin ^³
FSP1 ^¹, ²
MTS1 ^², ³
Metastasin ^³
OTTHUMP00000015467 ^²
OTTHUMP00000015468 ^²
OTTHUMP00000015469 ^²
OTTHUMP00000032895 ^²
P9KA ^¹, ²
PEL98 ^¹, ²

Descriptions
Placental calcium-binding protein ^³
Protein Mts1 ^³
S100 calcium binding protein A4 ^²
S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) ^¹, ²
S100 calcium-binding protein A4 ^², ³
S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) ^¹, ²
fibroblast-specific protein-1 ^²
malignant transformation suppression 1 ^²

External Ids
HGNC: 10494¹
Entrez Gene: 6275²
UniProtKB: P26447³
Ensembl: ENSG00000196154⁷

Search outside databases for aliases for S100A4 gene

Previous GC identifers: GC01M151332 GC01M149298 GC01M150343 GC01M150784 GC01M150585 GC01M150330

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A4:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand

calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide

range of cells, and involved in the regulation of a number of cellular processes such as cell

cycle progression and differentiation. S100 genes include at least 13 members which are located as

a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin

polymerization. Chromosomal rearrangements and altered expression of this gene have been

implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same

protein, have been identified. [provided by RefSeq]

Gene Wiki entry for S100A4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the S100A4 gene

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q12-q22

S100A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M151783: (about GC identifiers)

Start:	151,782,713 bp from pter
End:	151,789,236 bp from pter
Size:	6,524 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447 (See protein sequence)

Recommended Name: Protein S100-A4

Size: 101 amino acids; 11729 Da

Subunit: Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode

PDB structures from and Proteopedia :

1M31 (3D)

2Q91 (3D)

3C1V (3D)

3CGA (3D)

Secondary accessions: Q6ICP8

REFSEQ proteins (2 alternative transcripts):

NP_002952.1 NP_062427.1

ENSEMBL proteins:

ENSP00000346294 ENSP00000357705 ENSP00000357704 ENSP00000357703

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for S100A4
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S100A4)
	Human Recombinant Proteins from Abnova (S100A4)

OriGene Purified Recombinant Human Protein: S100A4

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for S100A4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for S100A4
	R&D Systems Antibodies for S100A4
	Antibodies from Abcam (S100A4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S100A4)
	Novus Biologicals Antibodies for S100A4

Assays for S100A4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P26447

ProtoNet protein and cluster: P26447

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_019554

Applied Biosystems Silencer® siRNAs for S100A4

Sigma-Aldrich siRNA for S100A4

Sigma-Aldrich shRNA for S100A4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100A4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002961
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002961
untagged cDNA clones in CMV expression vector (see all 2): NM_002961

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002961

Genatlas biochemistry entry for S100A4:

S100 calcium binding protein A4,murine placental homolog,epidermal differentiation

complex,possessing metastasis-inducing capabilities,involved in the regulation of cell cycle

progression,modulating intercellular adhesion,and invasive and metastatic properties of cancer

cells

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for S100a4):

cellular

lethality-prenatal/perinatal

normal

tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	TAS	8204608
GO:0042802	identical protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for S100A4

5/49 Interacting proteins for S100A4 (ENSP00000346294³ P26447²) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAT3	P46379²	MINT-63612
UNC119	Q13432²	MINT-63611
TP53	ENSP00000269305³	STRING (score=.996)
ANXA2	ENSP00000346032³	STRING (score=.973)
METAP2	ENSP00000325312³	STRING (score=.964)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001837	epithelial to mesenchymal transition	TAS	14679171

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A4
7 Novoseek chemical compound relationships for S100A4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	26.04	3	11029520 (2)
calcium	23.84	57	12756252 (5), 11914069 (4), 18783790 (4), 15856021 (4) (see all 19)
progesterone	4.48	4	17673926 (1), 19056847 (1)
oligonucleotide	0.00	1	16367903 (1)
nacl	0.00	2	11108967 (1), 17200116 (1)
steroid	0.00	1	14598884 (1)
tyrosine	0.00	3	18435928 (1), 11836260 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_019554

Sigma-Aldrich siRNA for S100A4

Sigma-Aldrich shRNA for S100A4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002961 NM_019554

REFSEQ mRNAs for S100A4 gene (2 alternative transcripts):

NM_002961.2 NM_019554.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002961 NM_019554

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002961
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002961
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002961

Additional cDNA sequence:

AK292083.1 AY754741.1 AY762982.1 BC000838.1 BC016300.1 BC024974.1 CR450345.1 M80563.1

16 DOTS entries:

DT.87017506 DT.95077872 DT.100819070 DT.95077836 DT.97859764 DT.95077834 DT.100697627 DT.101984896

DT.121326675 DT.100059942 DT.121326679 DT.121326682 DT.121326683 DT.100697637 DT.212995 DT.97800192

24/388 AceView cDNA sequences (see all 388 ):

AA296087 CR542163 BM741613 CR542185 BC016300 AA991227 BM747639 CB109571

AA872450 AA330444 BM687134 F27477 BE877461 AA057375 BM755230 BM687683

CB110143 BM759609 AI168075 BG034589 BM764773 BM770932 BM126466 BM699838

highest scoring ESTs for S100A4:

M80563 AA317260 AA330018 AU100338 AV712228 AV714505 AV735678 AV763009 AV763129 BC000838

Unigene Cluster for S100A4:

S100 calcium binding protein A4

Hs.654444 [show with all ESTs]

Unigene Representative Sequence: BQ945534

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for S100A4 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f
SP1:							-						-		-				-
SP2:							-				-		-		-				-
SP3:							-		-		-		-		-				-
SP4:							-		-		-		-		-
SP5:											-		-		-				-

About this scheme

ECgene alternative splicing isoforms for S100A4

4 Ensembl transcripts including schematic representations:

ENST00000354332 ENST00000368716 ENST00000368715 ENST00000368714

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100A4

¹ / ² / ³

4 probe-sets matching S100A4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38087_s_at²^{, 3}	U95-A	2	1.00	0.97	0.89	1.06	W72186	0.60	0.83	0.73	1
38088_r_at²^{, 3}	U95-A	2	1.00	0.81	0.75	0.95	M80563	1.00	0.90	0.95	1
203186_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002961	0.60	0.83	0.73	1
203186_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks S100A4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGTGTAACG

SOURCE GeneReport for Unigene cluster: Hs.654444
Expression variation in blood from EXPOLDB for S100A4
UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100A4 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S100A4¹	--	S100 calcium binding protein A4	90.76(n) 95.05(a)	403787 NM_001003161.1 NP_001003161.1
chimpanzee (Pan troglodytes)	S100A4¹	--	S100 calcium binding protein A4	99.67(n) 100(a)	457320 XM_001138834.1 XP_001138834.1
cow (Bos taurus)	S100A4¹	--	S100 calcium binding protein A4	91.42(n) 96.04(a)	282343 NM_174595.2 NP_777020.1
rat (Rattus norvegicus)	S100a4¹	--	S100 calcium-binding protein A4	88.78(n) 91.09(a)	24615 NM_012618.1 NP_036750.1
mouse (Mus musculus)	S100a4^{1, 5}	3 (43.60 cM)⁵	S100 calcium binding protein A4^{1, 5}	89.11(n)¹ 93.07(a)¹	20198¹ NM_011311.1¹ NP_035441.1¹ AK003065⁵ AK160522⁵ (see all 14)

About this table Species with no ortholog for S100A4

ENSEMBL Gene Tree for S100A4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S100A4 gene

S100A6² S100A3² S100A1² S100Z² S100A5² S100A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in S100A4 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 28)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1803244^1,2	C,F,H	151782982(-)	`AGCAAT/CTTGGA`	2	N/N	syn¹		5		EU EA WA NA	492
	rs1050923^1,2	C,F	151783796(-)	`TCAGAA/GCTAAA`	2	E/E	syn¹		1		NA	70
--	rs2857739^1,2	--	151785310(-)	`catctC/TCCCCC`	2	--	ng3¹ trp³		0	--	--	--	--
--	rs59055694^1,2	--	151785365(+)	`ATAGA-/GAGA CTTCT`	2	--	ng3¹		0	--	--	--	--
--	rs60969679^1,2	--	151785577(+)	`ATTCAA/GAAACA`	2	--	ng3¹		0	--	--	--	--
	rs15262^1,2	--	151783756(-)	`TCTTGG/TGGAAA`	2	G/W	mis¹		0	--	--	--	--
--	rs35737518^1,2	--	151785222(+)	`GTCCC-/CATGGG`	2	--	ng3¹		0	--	--	--	--
--	rs58742808^1,2	--	151785474(+)	`GGATCA/TTTTGA`	2	--	ng3¹		0	--	--	--	--
--	rs72256433^1,2	--	151785362(+)	`AACAT-/AGAG AGACT`	2	--	ng3¹		0	--	--	--	--
--	rs1803245^1,2	--	151783866(-)	`CCTGGA/TTGTGA`	2	D/V	mis¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for S100A4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114210

10/48 Novoseek disease relationships for S100A4 gene (see all 48 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	67.87	194	16265347 (7), 18360353 (6), 17101323 (6), 17051636 (5) (see all 83)
cancer	51.37	82	9703888 (5), 18803290 (3), 18056757 (3), 16865243 (2) (see all 49)
carcinoma	50.58	44	10738249 (4), 11875708 (4), 17276942 (4), 19194111 (3) (see all 20)
tumors	50.53	155	17673926 (5), 12445462 (5), 7794250 (4), 16551737 (4) (see all 66)
adenocarcinoma	46.63	39	16685438 (6), 11029520 (5), 12239456 (4), 9815629 (4) (see all 12)
thyroid carcinoma anaplastic	43.91	5	16551737 (2), 16265347 (1)
breast cancer	42.80	43	18771601 (3), 8824556 (3), 17565747 (3), 16489073 (3) (see all 21)
primary tumor	40.74	11	16489073 (2), 11839590 (2), 15006621 (1), 19043527 (1) (see all 6)
carcinoma squamous cell	40.09	18	11251165 (5), 10737717 (3), 15006621 (2), 16297707 (2) (see all 5)
adenoma follicular	39.22	3	15713996 (1), 17308358 (1)

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Tumor Gene Database: S100A4

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/260 PubMed articles for S100A4 gene (see all 260 ):

Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1). (PubMed id 11836260)^{1, 3, 4} Kriajevska M....Lukanidin E. (2002)
Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy. (PubMed id 12379109)^{1, 3, 4} Vallely K.M....Weber D.J. (2002)
Calcyclin and calvasculin exist in human platelets. (PubMed id 1482346)^{1, 3, 4} Tomida Y.... Hidaka H. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)^{3, 4} Engelkamp D.... Heizmann C.W. (1993)
Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences. (PubMed id 1329089)^{3, 4} Tulchinsky E.M.... Lukanidin E. (1992)
S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. (PubMed id 1384693)^{3, 4} Engelkamp D.... Heizmann C.W. (1992)
Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation. (PubMed id 3155863)^{2, 3} Stoler A. and Bouck N. (1985)
Metastasis-associated protein S100A4: spotlight on its role in cell migration. (PubMed id 17504119)^{1, 3} Tarabykina S....Kriajevska M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6275	HGNC: 10494	AceView: S100A3andS100A4	Ensembl:ENSG00000196154	euGenes: HUgn6275
ECgene: S100A4	H-InvDB: S100A4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for S100A4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for S100A4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for S100A4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100A4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100A4		Antibodies for S100A4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S100A4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (S100A4)
	Antibodies (S100A4)
	Chimera RNAi (S100A4)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (S100A4)
	Antibodies (S100A4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for S100A4

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S100A4 Gene

protein-coding GIFtS: 62

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100A4 (Gene Symbol)
18A2
42A
CAPL
Calvasculin
FSP1
MTS1
Metastasin
OTTHUMP00000015467
OTTHUMP00000015468
OTTHUMP00000015469
OTTHUMP00000032895
P9KA
PEL98
Placental calcium-binding protein
Protein Mts1
S100 calcium binding protein A4
S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
S100 calcium-binding protein A4
S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
fibroblast-specific protein-1
malignant transformation suppression 1

S100A4 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor S100A4

Summariesfor S100A4

Genomic Locationfor S100A4

Proteinsfor S100A4

Protein Domains/Familiesfor S100A4

Gene Functionfor S100A4

Pathways & Interactionsfor S100A4

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Transcriptsfor S100A4

Expression for S100A4

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Search for S100A4

Genome Databases showing S100A4

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Specialized Databases showing S100A4

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100A4

Summaries
for S100A4

Genomic Location
for S100A4

Proteins
for S100A4

Protein Domains/
Families
for S100A4

Gene Function
for S100A4

Pathways & Interactions
for S100A4

Drugs & Compounds
for S100A4

Transcripts
for S100A4

Expression
for S100A4

Orthologs
for S100A4

Paralogs
for S100A4

SNPs/Variants
for S100A4

Disorders & Mutations
for S100A4

Medical News
for S100A4

Publications
for S100A4

Licensable Technologies
for S100A4

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for S100A4