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Aliases for S100A4 Gene

Aliases for S100A4 Gene

  • S100 Calcium Binding Protein A4 2 3
  • CAPL 3 4 6
  • S100 Calcium-Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog) 2 3
  • Placental Calcium-Binding Protein 3 4
  • Fibroblast-Specific Protein-1 2 3
  • Protein Mts1 3 4
  • MTS1 3 4
  • S100 Calcium Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog) 2
  • Leukemia Multidrug Resistance Associated Protein 3
  • Malignant Transformation Suppression 1 3
  • S100 Calcium-Binding Protein A4 4
  • Protein S100-A4 3
  • Calvasculin 4
  • Metastasin 4
  • PEL98 3
  • 18A2 3
  • FSP1 3
  • P9KA 3
  • 42A 3

External Ids for S100A4 Gene

Previous Symbols for S100A4 Gene

  • MTS1
  • CAPL

Summaries for S100A4 Gene

Entrez Gene Summary for S100A4 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A4 Gene

S100A4 (S100 Calcium Binding Protein A4) is a Protein Coding gene. Diseases associated with S100A4 include bile duct adenocarcinoma and pancreatic cancer. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A6.

Gene Wiki entry for S100A4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A4 Gene

Genomics for S100A4 Gene

Genomic Location for S100A4 Gene

Start:
153,543,613 bp from pter
End:
153,550,136 bp from pter
Size:
6,524 bases
Orientation:
Minus strand

Genomic View for S100A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A4 Gene

Regulatory Elements for S100A4 Gene

Transcription factor binding sites by QIAGEN in the S100A4 gene promoter:

Proteins for S100A4 Gene

  • Protein details for S100A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26447-S10A4_HUMAN
    Recommended name:
    Protein S100-A4
    Protein Accession:
    P26447
    Secondary Accessions:
    • A8K7R8
    • D3DV46
    • Q6ICP8

    Protein attributes for S100A4 Gene

    Size:
    101 amino acids
    Molecular mass:
    11729 Da
    Quaternary structure:
    • Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode.

    Three dimensional structures from OCA and Proteopedia for S100A4 Gene

neXtProt entry for S100A4 Gene

Proteomics data for S100A4 Gene at MOPED

Post-translational modifications for S100A4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys57

Other Protein References for S100A4 Gene

No data available for DME Specific Peptides for S100A4 Gene

Domains for S100A4 Gene

Gene Families for S100A4 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

UniProtKB/Swiss-Prot:

S10A4_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • P26447
Family:
  • Belongs to the S-100 family.:
    • P26447
genes like me logo Genes that share domains with S100A4: view

Function for S100A4 Gene

Molecular function for S100A4 Gene

GENATLAS Biochemistry: S100 calcium binding protein A4,murine placental homolog,epidermal differentiation complex,possessing metastasis-inducing capabilities,involved in the regulation of cell cycle progression,modulating intercellular adhesion,and invasive and metastatic properties of cancer cells

Gene Ontology (GO) - Molecular Function for S100A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 14640694
GO:0042802 identical protein binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with S100A4: view
genes like me logo Genes that share phenotypes with S100A4: view

Animal Models for S100A4 Gene

MGI Knock Outs for S100A4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for S100A4 Gene

Localization for S100A4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A4 Gene COMPARTMENTS Subcellular localization image for S100A4 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for S100A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 12118070
GO:0043005 neuron projection IEA --
GO:0048471 perinuclear region of cytoplasm IDA 15033494
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with S100A4: view

Pathways for S100A4 Gene

SuperPathways for S100A4 Gene

genes like me logo Genes that share pathways with S100A4: view

Pathways by source for S100A4 Gene

1 Cell Signaling Technology pathway for S100A4 Gene

Gene Ontology (GO) - Biological Process for S100A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition TAS 14679171
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 15033494
genes like me logo Genes that share ontologies with S100A4: view

Compounds for S100A4 Gene

(1) HMDB Compounds for S100A4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for S100A4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Trifluoperazine
  • Trifluoperazin
117-89-5 target inhibitor

(11) Novoseek inferred chemical compound relationships for S100A4 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 46.6 3
matrigel 28.9 2
calcium 25.2 42
estrogen 11 6
progesterone 6.02 3
genes like me logo Genes that share compounds with S100A4: view

Transcripts for S100A4 Gene

Unigene Clusters for S100A4 Gene

S100 calcium binding protein A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: -

Relevant External Links for S100A4 Gene

GeneLoc Exon Structure for
S100A4
ECgene alternative splicing isoforms for
S100A4

Expression for S100A4 Gene

mRNA expression in normal human tissues for S100A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A4 Gene

This gene is overexpressed in Whole Blood (17.6) and Artery - Aorta (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A4 Gene

SOURCE GeneReport for Unigene cluster for S100A4 Gene Hs.654444

mRNA Expression by UniProt/SwissProt for S100A4 Gene

P26447-S10A4_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with S100A4: view

Orthologs for S100A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A4 36
  • 99.67 (n)
  • 100 (a)
S100A4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100A4 36
  • 91.42 (n)
  • 96.04 (a)
S100A4 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A4 36
  • 90.76 (n)
  • 95.05 (a)
S100A4 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100a4 36
  • 89.44 (n)
  • 93.07 (a)
S100a4 16
S100a4 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A4 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100A4 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a4 36
  • 88.78 (n)
  • 91.09 (a)
chicken
(Gallus gallus)
Aves S100A4 36
  • 72.39 (n)
  • 67.68 (a)
S100A4 37
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii icn 36
  • 60.92 (n)
  • 57.47 (a)
Species with no ortholog for S100A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A4 Gene

ENSEMBL:
Gene Tree for S100A4 (if available)
TreeFam:
Gene Tree for S100A4 (if available)

Paralogs for S100A4 Gene

Selected SIMAP similar genes for S100A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A4: view

Variants for S100A4 Gene

Sequence variations from dbSNP and Humsavar for S100A4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2857739 -- 153,546,210(-) catct(C/T)CCCCC upstream-variant-2KB
rs2857740 -- 153,546,140(-) CATCT(C/T)CTTTC upstream-variant-2KB
rs28373960 -- 153,545,669(+) CACAT(C/T)TGGCC intron-variant
rs35558506 -- 153,545,453(+) TACCC(-/C)ACAGG intron-variant
rs35737518 -- 153,546,122(+) GTCCC(-/C)ATGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S100A4 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Relevant External Links for S100A4 Gene

HapMap Linkage Disequilibrium report
S100A4

Disorders for S100A4 Gene

(1) University of Copenhagen DISEASES for S100A4 Gene

(48) Novoseek inferred disease relationships for S100A4 Gene

Disease -log(P) Hits PubMed IDs
metastasis 67.6 175
tumors 52.5 133
cancer 51.1 76
carcinoma 49.5 39
adenocarcinoma 46.5 32

Relevant External Links for S100A4

Genetic Association Database (GAD)
S100A4
Human Genome Epidemiology (HuGE) Navigator
S100A4
Tumor Gene Database (TGDB):
S100A4
genes like me logo Genes that share disorders with S100A4: view

No data available for UniProtKB/Swiss-Prot for S100A4 Gene

Publications for S100A4 Gene

  1. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis- associated protein S100A4 (Mts1). (PMID: 11836260) Kriajevska M. … Lukanidin E. (J. Biol. Chem. 2002) 3 4 23
  2. Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy. (PMID: 12379109) Vallely K.M. … Weber D.J. (Biochemistry 2002) 3 4 23
  3. Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies. (PMID: 12439718) Pedersen K.B. … Maelandsmo G.M. (Br. J. Cancer 2002) 3 23
  4. Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. (PMID: 12445462) Belot N. … Decaestecker C. (Biochim. Biophys. Acta 2002) 3 23
  5. A role for CCN3 (NOV) in calcium signalling. (PMID: 12147716) Li C.L. … Perbal B. (MP, Mol. Pathol. 2002) 3 23

Products for S100A4 Gene

Sources for S100A4 Gene

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