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S100A4 Gene

protein-coding   GIFtS: 67
GCID: GC01M153518

S100 Calcium Binding Protein A4

(Previous names: S100 calcium-binding protein A4 (calcium protein, calvasculin,...)
(Previous symbols: MTS1, CAPL)
  See S100A4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A41 2     FSP12
CAPL1 2 3 5     P9KA2
MTS11 2 3     PEL982
S100 Calcium-Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin,
Murine Placental Homolog)1 2
     Leukemia Multidrug Resistance Associated Protein2
Fibroblast-Specific Protein-11 2     Malignant Transformation Suppression 12
Placental Calcium-Binding Protein2 3     Protein S100-A42
Protein Mts12 3     Calvasculin3
S100 Calcium Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin,
Murine Placental Homolog)1
     Metastasin3
18A22     S100 Calcium-Binding Protein A43
42A2     

External Ids:    HGNC: 104941   Entrez Gene: 62752   Ensembl: ENSG000001961547   OMIM: 1142105   UniProtKB: P264473   

Export aliases for S100A4 gene to outside databases

Previous GC identifers: GC01M151332 GC01M149298 GC01M150343 GC01M150784 GC01M150585 GC01M150330 GC01M151783 GC01M153517 GC01M124879


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A4 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in
motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene
have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein,
have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100A4 Gene:
S100A4 (S100 calcium binding protein A4) is a protein-coding gene. Diseases associated with S100A4 include bile duct adenocarcinoma, and colon adenocarcinoma. GO annotations related to this gene include calcium-dependent protein binding and calcium ion binding. An important paralog of this gene is S100A11.

Gene Wiki entry for S100A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A4 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A4 promoter sequence
   Search Chromatin IP Primers for S100A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q12-q22

S100A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153518:  view genomic region     (about GC identifiers)

Start:
153,516,089 bp from pter      End:
153,522,612 bp from pter
Size:
6,524 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447 (See protein sequence)
Recommended Name: Protein S100-A4  
Size: 101 amino acids; 11729 Da
Subunit: Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode
Selected PDB 3D structures from and Proteopedia for S100A4 (see all 10):
1M31 (3D)        2LNK (3D)        2Q91 (3D)        3C1V (3D)        3CGA (3D)        3KO0 (3D)    
Secondary accessions: A8K7R8 D3DV46 Q6ICP8

Explore the universe of human proteins at neXtProt for S100A4: NX_P26447

Explore proteomics data for S100A4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys57
  • Modification sites at PhosphoSitePlus

  • See S100A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002952.1  NP_062427.1  

    ENSEMBL proteins: 
     ENSP00000357704   ENSP00000346294   ENSP00000357705   ENSP00000357703  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    Selected InterPro protein domains (see all 6):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR028496 S100-A2/S100-A4
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P26447

    ProtoNet protein and cluster: P26447

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Find genes that share domains with S100A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for S100A4:
    S100 calcium binding protein A4,murine placental homolog,epidermal differentiation complex,possessing
    metastasis-inducing capabilities,involved in the regulation of cell cycle progression,modulating intercellular
    adhesion,and invasive and metastatic properties of cancer cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI14640694
    GO:0042802identical protein binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with S100A4           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for S100a4):
     cellular  hematopoietic system  immune system  mortality/aging  normal 
     tumorigenesis 

    Find genes that share phenotypes with S100A4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for S100A4: S100a4tm1.1Abres S100a4tm1Amba

       genOway: Develop your customized and physiologically relevant rodent model for S100A4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol3
    extracellular2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA12118070
    GO:0043005neuron projection IEA--
    GO:0048471perinuclear region of cytoplasm IDA15033494
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with S100A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S100A4 About    
    See pathways by source

    SuperPathContained pathways About
    1Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with S100A4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for S100A4
        Ca, cAMP and Lipid Signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including S100A4: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for S100A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for S100A4 (P264471, 2, 3 ENSP000003462944) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AREGP155141, 2, 3EBI-717058,EBI-953674 MINT-7256618 MINT-7256636 MINT-7256485 MINT-7256567 I2D: score=1 
    TP53P046371, 2, 3, ENSP000002693054EBI-717058,EBI-366083 MINT-7905196 MINT-7256502 MINT-7905358 I2D: score=4 STRING: ENSP00000269305
    MDM2Q009871, 2, 3, ENSP000004172814EBI-717058,EBI-389668 MINT-7905104 MINT-7905247 MINT-7905376 I2D: score=2 STRING: ENSP00000417281
    BTCP350701, 2, 3EBI-717058,EBI-6590057 MINT-7256512 MINT-7256593 I2D: score=1 
    BAG6P463792, 3MINT-63612 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition TAS14679171
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IDA15033494

    Find genes that share ontologies with S100A4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for S100A4 (S10A4)

    1 HMDB Compound for S100A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for S100A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TrifluoperazineTrifluoperazin (see all 13)117-89-5targetinhibitor20421509 10592235

    Selected Novoseek inferred chemical compound relationships for S100A4 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 46.6 5 7536040 (1), 10091942 (1), 19703228 (1)
    matrigel 28.9 3 11029520 (2)
    calcium 25.2 71 12756252 (5), 20083144 (5), 11914069 (4), 15856021 (4) (see all 22)
    estrogen 11 8 16489073 (2), 15956747 (1), 17673926 (1), 19834055 (1) (see all 5)
    progesterone 6.02 5 17673926 (1), 19834055 (1), 19056847 (1)
    oligonucleotide 0 1 16367903 (1)
    nacl 0 2 11108967 (1), 17200116 (1)
    steroid 0 1 14598884 (1)
    tyrosine 0 3 18435928 (1), 11836260 (1)
    phosphatidylserine 0 1 17638890 (1)



    Find genes that share compounds with S100A4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for S100A4 gene (2 alternative transcripts): 
    NM_002961.2  NM_019554.2  

    Unigene Cluster for S100A4:

    S100 calcium binding protein A4
    Hs.654444  [show with all ESTs]
    Unigene Representative Sequence: CF619147
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368715 ENST00000481009 ENST00000354332(uc001fby.3) ENST00000468373
    ENST00000368716(uc001fbz.3) ENST00000368714
    miRNA
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    Additional mRNA sequence: 

    AK292083.1 AY754741.1 AY762982.1 BC000838.1 BC016300.1 BC024974.1 CR450345.1 M80563.1 

    17 DOTS entries:

    DT.87017506  DT.95077872  DT.100819070  DT.95077836  DT.97859764  DT.95077834  DT.100697627  DT.101984896 
    DT.121326675  DT.100059942  DT.100697637  DT.121326679  DT.121326682  DT.121326683  DT.65285093  DT.212995 
    DT.97800192 

    Selected AceView cDNA sequences (see all 388):

    BM739296 Z18948 BU175597 F27477 AJ713270 BM754955 CB109571 CR450345 
    BM741613 AA872450 BC012893 CB107318 R91545 CB109749 CB108379 BM760188 
    H58281 BM759609 W94732 BM760112 BT006955 BE877461 BM755230 AA330444 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for S100A4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                    -                 -     -           -                                 
    SP2:                    -           -     -     -           -                                 
    SP3:                    -     -     -     -     -           -                                 
    SP4:                    -     -     -     -     -                                             
    SP5:                                -     -     -           -                                 


    ECgene alternative splicing isoforms for S100A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S100A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGTAACG
    S100A4 Expression
    About this image


    S100A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Dermis (Integumentary System)    fully expand to see all 5 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Tendon & Ligament
             Human periodontal ligament Fibroblasts (HPLF)   
    S100A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S100A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654444

    UniProtKB/Swiss-Prot: S10A4_HUMAN, P26447
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including S100A4: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S100A4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a41 , 5 S100 calcium binding protein A41, 5 89.44(n)1
    93.07(a)1
      3 (39.27 cM)5
    201981  NM_011311.21  NP_035441.11 
     906037715 
    chicken
    (Gallus gallus)
    Aves S100A41 S100 calcium binding protein A4 72.39(n)
    67.68(a)
      101747315  XM_004948219.1  XP_004948276.1 
    zebrafish
    (Danio rerio)
    Actinopterygii icn1 ictacalcin 60.92(n)
    57.47(a)
      336655  NM_212761.2  NP_997926.1 


    ENSEMBL Gene Tree for S100A4 (if available)
    TreeFam Gene Tree for S100A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S100A4 gene
    S100A112  S100A62  S100A12  S100A122  S100B2  S100A32  S100A102  S100Z2  
    S100P2  S100A52  S100A22  S100A92  
    Selected SIMAP similar genes for S100A4 using alignment to 1 protein entry:     S10A4_HUMAN(see all similar genes):
    S100A2    S100A1    S100A6    S100B    S100A11    S100A5
    S100A12    S100A13    S100A16    S100P    S100Z    S100A14
    S100A3    S100A9    S100A10    RPTN    S100G    S100A7A

    Find genes that share paralogs with S100A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S100A4 (see all 124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114861371,2
    C,F--160016992(+) GTCAAC/TGTCAG 2 -- ds50015Minor allele frequency- T:0.15NA WA CSA 125
    rs114861381,2
    C,F--160016996(+) ACGTCA/CGCACT 2 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1144487131,2
    F--160017133(+) AGATAT/GGACCT 2 -- ds50011Minor allele frequency- G:0.12WA 118
    rs7303471,2
    C,F,A,H--160017190(-) CTCCCA/CCCTCT 2 -- ds500114Minor allele frequency- C:0.21EA NA NS WA CSA 1248
    rs1499859151,2
    --160017302(+) TCTATC/TGCCTG 2 -- ds50010--------
    rs730263411,2
    C,F--160017312(+) GTGCAC/AACACA 2 -- ds50014Minor allele frequency- A:0.15WA CSA 125
    rs1465636491,2
    --160017397(+) CTCCCC/TACCAC 2 -- ds50010--------
    rs285871711,2
    C,F--160017429(+) GTCCCC/TAACCC 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1829496121,2
    --160017438(+) CCACGC/TCCCCA 2 -- ds50010--------
    rs1134436971,2
    C,F--160017524(+) AGGAGC/GCAGGG 2 -- ut312Minor allele frequency- G:0.07CSA WA 122

    HapMap Linkage Disequilibrium report for S100A4 (153516089 - 153522612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for S100A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831603CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A4
    DNA2.0 Custom Variant and Variant Library Synthesis for S100A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114210    OMIM disorders: --

    5 diseases for S100A4:    
    About MalaCards
    bile duct adenocarcinoma    colon adenocarcinoma    adenocarcinoma    pancreatic cancer
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for S100A4:
    Carcinoma

    Find genes that share disorders with S100A4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for S100A4 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 67.6 218 19820999 (9), 16265347 (7), 18360353 (6), 17101323 (6) (see all 91)
    tumors 52.5 184 20442771 (7), 17673926 (5), 12445462 (5), 7794250 (4) (see all 80)
    cancer 51.1 101 19703228 (6), 9703888 (5), 18803290 (3), 19808905 (3) (see all 55)
    carcinoma 49.5 47 10738249 (4), 11875708 (4), 17276942 (4), 19194111 (3) (see all 22)
    adenocarcinoma 46.5 39 16685438 (6), 11029520 (5), 12239456 (4), 9815629 (4) (see all 12)
    breast cancer 42.4 50 18771601 (3), 8824556 (3), 17565747 (3), 16489073 (3) (see all 23)
    primary tumor 41.2 12 16489073 (2), 11839590 (2), 19365673 (1), 11836260 (1) (see all 7)
    thyroid carcinoma anaplastic 40.5 5 16551737 (2), 16265347 (1)
    pancreatic cancer 37.7 21 16865243 (4), 18350635 (4), 19799859 (3), 19653048 (3) (see all 7)
    pancreatic carcinoma 37.4 10 11786397 (6), 19653048 (1), 12874021 (1)

    Genetic Association Database (GAD): S100A4
    Human Genome Epidemiology (HuGE) Navigator: S100A4 (2 documents)
    Tumor Gene Database (TGDB): S100A4

    Export disorders for S100A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S100A4 gene, integrated from 10 sources (see all 382):
    (articles sorted by number of sources associating them with S100A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis- associated protein S100A4 (Mts1). (PubMed id 11836260)1, 2, 9 Kriajevska M.... Lukanidin E. (J. Biol. Chem. 2002)
    2. Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy. (PubMed id 12379109)1, 2, 9 Vallely K.M....Weber D.J. (Biochemistry 2002)
    3. Calcyclin and calvasculin exist in human platelets. (PubMed id 1482346)1, 2, 9 Tomida Y.... Hidaka H. (Biochem. Biophys. Res. Commun. 1992)
    4. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    5. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)1, 2 Engelkamp D.... Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    9. Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences. (PubMed id 1329089)1, 2 Tulchinsky E.M.... Lukanidin E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    10. S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. (PubMed id 1384693)1, 2 Engelkamp D.... Heizmann C.W. (Biochemistry 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6275 HGNC: 10494 AceView: S100A3andS100A4 Ensembl:ENSG00000196154 euGenes: HUgn6275
    ECgene: S100A4 H-InvDB: S100A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S100A4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S100A4 gene:
    Search GeneIP for patents involving S100A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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