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Aliases for S100A4 Gene

Aliases for S100A4 Gene

  • S100 Calcium Binding Protein A4 2 3 5
  • S100 Calcium-Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog) 2 3
  • Placental Calcium-Binding Protein 3 4
  • Fibroblast-Specific Protein-1 2 3
  • Protein Mts1 3 4
  • MTS1 3 4
  • CAPL 3 4
  • S100 Calcium Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog) 2
  • Leukemia Multidrug Resistance Associated Protein 3
  • Malignant Transformation Suppression 1 3
  • S100 Calcium-Binding Protein A4 4
  • Protein S100-A4 3
  • Calvasculin 4
  • Metastasin 4
  • PEL98 3
  • FSP1 3
  • 18A2 3
  • P9KA 3
  • 42A 3

External Ids for S100A4 Gene

Previous HGNC Symbols for S100A4 Gene

  • MTS1
  • CAPL

Previous GeneCards Identifiers for S100A4 Gene

  • GC01M151332
  • GC01M149298
  • GC01M150343
  • GC01M150784
  • GC01M150585
  • GC01M150330
  • GC01M151783
  • GC01M153517
  • GC01M124879

Summaries for S100A4 Gene

Entrez Gene Summary for S100A4 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A4 Gene

S100A4 (S100 Calcium Binding Protein A4) is a Protein Coding gene. Diseases associated with S100A4 include Bile Duct Adenocarcinoma and Pancreatic Cancer. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is S100A2.

Gene Wiki entry for S100A4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A4 Gene

Genomics for S100A4 Gene

Regulatory Elements for S100A4 Gene

Enhancers for S100A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154270 0.4 ENCODE 12 -722.3 -722274 3.3 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 HAX1 CHTOP S100A4 EFNA4 DCST1 THBS3 SCAMP3 ENSG00000272030 SLC27A3 C1orf43
GH01F153984 0.5 ENCODE 12 -436.0 -436036 3.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 RAB13 NPR1 S100A4 RPS27 CREB3L4 HAX1 GC01P153977
GH01F154320 0.9 Ensembl ENCODE 12 -771.3 -771320 1.8 PKNOX1 ATF1 ARNT CREB3L1 SIN3A ARID4B ZNF48 CBX5 GATA2 NCOA1 NUP210L S100A4 ATP8B2 AQP10 RAB13
GH01F153494 1 Ensembl ENCODE 11.6 +54.9 54943 0.4 PKNOX1 INSM2 KLF17 ZNF2 RAD21 ZNF366 ZNF143 ZNF391 ZNF654 SP3 SLC27A3 ENSG00000238279 S100A6 S100A5 S100A3 S100A4 PGLYRP4 CHTOP ENSG00000272030 S100A9
GH01F153561 1.3 FANTOM5 ENCODE 6.7 -15.4 -15426 8.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 INTS3 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 ENSG00000272654 SNAPIN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around S100A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A4 Gene

153,543,613 bp from pter
153,550,136 bp from pter
6,524 bases
Minus strand

Genomic View for S100A4 Gene

Genes around S100A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A4 Gene

Proteins for S100A4 Gene

  • Protein details for S100A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A4
    Protein Accession:
    Secondary Accessions:
    • A8K7R8
    • D3DV46
    • Q6ICP8

    Protein attributes for S100A4 Gene

    101 amino acids
    Molecular mass:
    11729 Da
    Quaternary structure:
    • Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode.

    Three dimensional structures from OCA and Proteopedia for S100A4 Gene

neXtProt entry for S100A4 Gene

Post-translational modifications for S100A4 Gene

  • Ubiquitination at Lys 57
  • Modification sites at PhosphoSitePlus

Other Protein References for S100A4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for S100A4 (S100A4)
  • Cloud-Clone Corp. Antibodies for S100A4

No data available for DME Specific Peptides for S100A4 Gene

Domains & Families for S100A4 Gene

Suggested Antigen Peptide Sequences for S100A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A4: view

Function for S100A4 Gene

Molecular function for S100A4 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A4,murine placental homolog,epidermal differentiation complex,possessing metastasis-inducing capabilities,involved in the regulation of cell cycle progression,modulating intercellular adhesion,and invasive and metastatic properties of cancer cells

Gene Ontology (GO) - Molecular Function for S100A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005509 calcium ion binding IEA,TAS --
GO:0005515 protein binding IPI 14640694
GO:0042802 identical protein binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with S100A4: view
genes like me logo Genes that share phenotypes with S100A4: view

Animal Models for S100A4 Gene

MGI Knock Outs for S100A4:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for S100A4 Gene

Localization for S100A4 Gene

Subcellular locations from

Jensen Localization Image for S100A4 Gene COMPARTMENTS Subcellular localization image for S100A4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for S100A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 12118070
GO:0043005 neuron projection IEA --
GO:0048471 perinuclear region of cytoplasm IDA 15033494
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with S100A4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for S100A4 Gene

Pathways & Interactions for S100A4 Gene

SuperPathways for S100A4 Gene

SuperPathway Contained pathways
1 Ca, cAMP and Lipid Signaling
genes like me logo Genes that share pathways with S100A4: view

Pathways by source for S100A4 Gene

1 Cell Signaling Technology pathway for S100A4 Gene

Gene Ontology (GO) - Biological Process for S100A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition TAS 14679171
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 15033494
genes like me logo Genes that share ontologies with S100A4: view

No data available for SIGNOR curated interactions for S100A4 Gene

Drugs & Compounds for S100A4 Gene

(10) Drugs for S100A4 Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Trifluoperazine Approved Pharma Antagonist, Target, inhibitor 5
Niclosamide Approved, Vet_approved Pharma 7
calcium Nutra 0
Anthelmintics Pharma 431
Anti-Infective Agents Pharma 21402

(6) Additional Compounds for S100A4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A4: view

Transcripts for S100A4 Gene

Unigene Clusters for S100A4 Gene

S100 calcium binding protein A4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: -

Relevant External Links for S100A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A4 Gene

mRNA expression in normal human tissues for S100A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A4 Gene

This gene is overexpressed in Whole Blood (x17.6) and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for S100A4 Gene

This gene is overexpressed in Tlymphocyte (6.9), NK cells (6.8), Monocytes (6.7), and CD4 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100A4 Gene

Protein tissue co-expression partners for S100A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of S100A4 Gene:


SOURCE GeneReport for Unigene cluster for S100A4 Gene:


mRNA Expression by UniProt/SwissProt for S100A4 Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with S100A4: view

Primer Products

Orthologs for S100A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A4 34 35
  • 99.67 (n)
(Bos Taurus)
Mammalia S100A4 34 35
  • 91.42 (n)
(Canis familiaris)
Mammalia S100A4 34 35
  • 90.76 (n)
(Mus musculus)
Mammalia S100a4 34 16 35
  • 89.44 (n)
(Rattus norvegicus)
Mammalia S100a4 34
  • 88.78 (n)
(Monodelphis domestica)
Mammalia S100A4 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia S100A4 35
  • 74 (a)
(Gallus gallus)
Aves S100A4 34 35
  • 72.39 (n)
(Danio rerio)
Actinopterygii icn 34
  • 60.92 (n)
Species where no ortholog for S100A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A4 Gene

Gene Tree for S100A4 (if available)
Gene Tree for S100A4 (if available)

Paralogs for S100A4 Gene

(20) SIMAP similar genes for S100A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A4: view

Variants for S100A4 Gene

Sequence variations from dbSNP and Humsavar for S100A4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050923 -- 153,544,696(-) TCAGA(A/G)CTAAA upstream-variant-2KB, reference, synonymous-codon
rs1051044 -- 153,543,684(-) TTTCC(A/C)CCCTG upstream-variant-2KB, utr-variant-3-prime
rs111251438 -- 153,544,908(+) CTTGG(C/T)GAGAC intron-variant, upstream-variant-2KB
rs111468775 -- 153,543,861(+) ACCTC(A/G)TTGTC upstream-variant-2KB, reference, synonymous-codon
rs111637694 -- 153,547,446(+) CCACA(A/G)GGGAG intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for S100A4 Gene

Variant ID Type Subtype PubMed ID
esv3587584 CNV gain 21293372
esv3587591 CNV gain 21293372
nsv1002705 CNV gain 25217958
nsv831603 CNV gain 17160897

Variation tolerance for S100A4 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A4 Gene

Disorders for S100A4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for S100A4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bile duct adenocarcinoma
pancreatic cancer
  • pancreatic carcinoma, somatic
breast cancer
  • breast cancer, invasive ductal
colorectal cancer
  • colorectal cancer, somatic
osteosarcoma, somatic
  • osteosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with S100A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A4 Gene

Publications for S100A4 Gene

  1. Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy. (PMID: 12379109) Vallely K.M. … Weber D.J. (Biochemistry 2002) 3 4 22 64
  2. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis- associated protein S100A4 (Mts1). (PMID: 11836260) Kriajevska M. … Lukanidin E. (J. Biol. Chem. 2002) 3 4 22 64
  3. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts K.E. … Fallon M.B. (Gastroenterology 2010) 3 46 64
  4. Significance of the S100A4 protein in psoriasis. (PMID: 19641515) Zibert J.R. … Grigorian M. (J. Invest. Dermatol. 2010) 3 22 64
  5. High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer. (PMID: 19820999) Wang Y.Y. … Chu Y.Q. (Ann. Surg. Oncol. 2010) 3 22 64

Products for S100A4 Gene

Sources for S100A4 Gene

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