S100A3 Gene

Aliases
for S100A3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M151335 GC01M149302 GC01M150344 GC01M150789 GC01M9A0063 GC01M9A0332 GC01M151786 GC01M124883

Summaries
for S100A3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for S100A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NC_018912.2  NT_004487.20  

SwitchGear Promoter luciferase reporter plasmid: S100A3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A3

S100A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153519:  view genomic region     (about GC identifiers)

Proteins
for S100A3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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5 PDB 3D structures from and Proteopedia for S100A3:

1KSO (3D)        3NSI (3D)        3NSK (3D)        3NSL (3D)        3NSO (3D)    

Explore the universe of human proteins at neXtProt for S100A3: NX_P33764

Explore proteomics data for S100A3 at MOPED

Post-translational modifications: 

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Domains /
Families
for S100A3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: P33764

Find genes that share domains with S100A3           About GenesLikeMe

Function
for S100A3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A3

Localization
for S100A3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
extracellular	2
cytoskeleton	1
nucleus	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for S100A3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Drugs & Compounds
for S100A3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for S100A3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for S100A3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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S100A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCTCCCACAC

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Epithelial Cells
Fetal Matrix Cells Hair Follicle
Hair (Integumentary System)
Fetal Matrix Cells Hair Follicle
Heart (Cardiovascular System)

Primer Products:		OriGene qPCR primer pairs and template standards for S100A3 OriGene qSTAR qPCR primer pairs in human, mouse for S100A3
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A3

Orthologs
for S100A3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for S100A3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for S100A3 gene

S100A11²  S100A6²  S100A1²  S100A12²  S100B²  S100A4²  S100A10²  S100Z²  

S100P²  S100A5²  S100A2²  S100A9²  

10 SIMAP similar genes for S100A3 using alignment to 1 protein entry:     S10A3_HUMAN:

S100A4    S100B    S100A2    S100A6    S100A5    S100A1

S100A11    S100Z    S100P    S100A10

Find genes that share paralogs with S100A3           About GenesLikeMe

Genomic Variants
for S100A3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for S100A3 (see all 99)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1483427481,2	C,F	--	153520297(+)	ATTTGT/CTGTAG	2	/N /S	mis1		1		NA	4552
rs20716311,2	C,H	--	153520317(-)	ACTGAG/ATTTCG	2	/E	syn1 ese3		6		NS EA NA	422
rs795760271,2	C	--	153520321(+)	ACTCAG/CTCTGT	2	/T /S	mis1		1		WA	118
rs1998630691,2	C	--	153520352(+)	GGTAAG/AGGAGT	1	--	int1		1		EU	1319
rs560890621,2	C,F	--	153520400(+)	CCTCCT/CTCCTC	1	--	int1		6		WA CSA NA	246
rs768574361,2	C,F	--	153520408(+)	CTCTCC/TCAAGT	1	--	int1		2		CSA WA	122
rs1492157001,2	C	--	153520418(+)	TGGACC/TCACCC	1	--	int1		0	--	--	--	--
rs759281711,2	C,F	--	153520451(+)	AGGGCC/TGACTT	1	--	int1		1		WA	118
rs780317811,2	C,F	--	153520513(+)	CCTCTC/TAGATT	1	--	int1		1		NA	120
rs1177911061,2	F	--	153520514(+)	CTCTCA/GGATTA	1	--	int1		1		EA	120

HapMap Linkage Disequilibrium report for S100A3 (153519805 - 153521848 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for S100A3:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv831603	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing S100A3

DNA2.0 Custom Variant and Variant Library Synthesis for S100A3

Disorders / Diseases
for S100A3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for S100A3

3 Novoseek inferred disease relationships for S100A3 gene    About this table

Publications
for S100A3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for S100A3 gene, integrated from 10 sources (see all 34): (articles sorted by number of sources associating them with S100A3)

Utopia: connect your pdf to the dynamic world of online information

1. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)^{1, 2, 3} Engelkamp D.... Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993)
2. Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle. (PubMed id 18083705)^{1, 2, 9} Kizawa K....Heizmann C.W. (J. Biol. Chem. 2008)
3. Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model. (PubMed id 9920417)^{1, 2, 9} Fritz G.... Kroneck P.M.H. (Biochim. Biophys. Acta 1998)
4. Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges. (PubMed id 21377473)^{1, 2} Unno M.... Kizawa K. (J. Mol. Biol. 2011)
5. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)^{1, 4} Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
8. Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles. (PubMed id 12470658)^{1, 2} Kizawa K....Heizmann C.W. (Biochem. Biophys. Res. Commun. 2002)
9. Metal-free MIRAS phasing: structure of apo-S100A3. (PubMed id 12136135)^{1, 2} Mittl P.R....Grutter M.G. (Acta Crystallogr. D 2002)
10. Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle. (PubMed id 8672544)^{1, 9} Kizawa K....Murakami U. (Biochim. Biophys. Acta 1996)

External Searches for S100A3 gene

Genome Databases showing S100A3 gene

Other Databases showing S100A3 gene

Specialized Databases showing S100A3 gene

Products
for S100A3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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