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Aliases for S100A3 Gene

Aliases for S100A3 Gene

  • S100 Calcium Binding Protein A3 2 3 5
  • S100 Calcium-Binding Protein A3 2 4
  • S100E 3 4
  • Protein S100-A3 3
  • Protein S-100E 4

External Ids for S100A3 Gene

Previous HGNC Symbols for S100A3 Gene

  • S100E

Previous GeneCards Identifiers for S100A3 Gene

  • GC01M151335
  • GC01M149302
  • GC01M150344
  • GC01M150789
  • GC01M9A0063
  • GC01M9A0332
  • GC01M151786
  • GC01M124883

Summaries for S100A3 Gene

Entrez Gene Summary for S100A3 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A3 Gene

S100A3 (S100 Calcium Binding Protein A3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A4.

UniProtKB/Swiss-Prot for S100A3 Gene

  • Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.

Gene Wiki entry for S100A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A3 Gene

Genomics for S100A3 Gene

Regulatory Elements for S100A3 Gene

Enhancers for S100A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F153539 0.5 ENCODE 24 +3.8 3841 12.0 PKNOX1 SIN3A ARID4B DMAP1 CBX5 FOS DEK SP3 SP5 NFYC S100A3 S100A16 S100A14 S100A1 S100A13 CHTOP INTS3 ENSG00000233222 ENSG00000243613 ILF2
GH01F153552 1.6 FANTOM5 Ensembl ENCODE 15 -4.3 -4329 2.6 CTCF HDAC1 FEZF1 DMAP1 ZFHX2 ZNF766 ZNF366 POLR2A ZBTB48 PRDM10 S100A3 CHTOP S100A13 S100A16 S100A14 S100A1 INTS3 ENSG00000233222 ENSG00000243613 ILF2
GH01F153561 1.3 FANTOM5 ENCODE 15 -16.2 -16190 8.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 INTS3 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 ENSG00000272654 SNAPIN
GH01F153531 1 FANTOM5 ENCODE 13.8 +14.2 14242 8.2 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS S100A3 INTS3 CHTOP ENSG00000272654 RN7SL44P S100A7L2 PGLYRP3 SLC39A1 PIR41635 S100A6
GH01F153577 1.6 FANTOM5 Ensembl ENCODE 12.8 -29.0 -28988 2.7 CTCF KLF1 JUN KLF17 ZIC2 ZNF664 FOSL1 ZNF121 ZFHX2 GATA3 S100A3 S100A16 S100A14 S100A1 S100A13 CHTOP S100A7L2 SNAPIN ILF2 NPR1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around S100A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A3 Gene

153,547,329 bp from pter
153,549,372 bp from pter
2,044 bases
Minus strand

Genomic View for S100A3 Gene

Genes around S100A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A3 Gene

Proteins for S100A3 Gene

  • Protein details for S100A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A3
    Protein Accession:
    Secondary Accessions:
    • D3DV51
    • Q6FGE4

    Protein attributes for S100A3 Gene

    101 amino acids
    Molecular mass:
    11713 Da
    Quaternary structure:
    • Homodimer and homotetramer for the citrullinated form.

    Three dimensional structures from OCA and Proteopedia for S100A3 Gene

neXtProt entry for S100A3 Gene

Post-translational modifications for S100A3 Gene

  • More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.

Other Protein References for S100A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S100A3 Gene

Domains & Families for S100A3 Gene

Gene Families for S100A3 Gene

Suggested Antigen Peptide Sequences for S100A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A3: view

Function for S100A3 Gene

Molecular function for S100A3 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A3,epidermal differentiation complex
UniProtKB/Swiss-Prot Function:
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.

Gene Ontology (GO) - Molecular Function for S100A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A3: view
genes like me logo Genes that share phenotypes with S100A3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for S100A3 Gene

Localization for S100A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A3 Gene


Subcellular locations from

Jensen Localization Image for S100A3 Gene COMPARTMENTS Subcellular localization image for S100A3 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for S100A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with S100A3: view

Pathways & Interactions for S100A3 Gene

SuperPathways for S100A3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A3 Gene


No data available for Pathways by source and SIGNOR curated interactions for S100A3 Gene

Drugs & Compounds for S100A3 Gene

(2) Drugs for S100A3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with S100A3: view

Transcripts for S100A3 Gene

mRNA/cDNA for S100A3 Gene

Unigene Clusters for S100A3 Gene

S100 calcium binding protein A3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A3 Gene

No ASD Table

Relevant External Links for S100A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x24.8) and Skin - Sun Exposed (Lower leg) (x5.8).

Protein differential expression in normal tissues from HIPED for S100A3 Gene

This gene is overexpressed in Hair follicle (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of S100A3 Gene:


SOURCE GeneReport for Unigene cluster for S100A3 Gene:


mRNA Expression by UniProt/SwissProt for S100A3 Gene:

Tissue specificity: Skin specific, specifically expressed at the inner endocuticle of hair fibers.
genes like me logo Genes that share expression patterns with S100A3: view

Primer Products

No data available for Protein tissue co-expression partners for S100A3 Gene

Orthologs for S100A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A3 34 35
  • 99.34 (n)
(Rattus norvegicus)
Mammalia S100a3 34
  • 90.76 (n)
(Mus musculus)
Mammalia S100a3 34 16 35
  • 90.1 (n)
(Canis familiaris)
Mammalia S100A3 34 35
  • 88.78 (n)
(Monodelphis domestica)
Mammalia S100A3 35
  • 79 (a)
(Bos Taurus)
Mammalia S100A3 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia S100A3 35
  • 53 (a)
Species where no ortholog for S100A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A3 Gene

Gene Tree for S100A3 (if available)
Gene Tree for S100A3 (if available)

Paralogs for S100A3 Gene

(10) SIMAP similar genes for S100A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A3: view

Variants for S100A3 Gene

Sequence variations from dbSNP and Humsavar for S100A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193921084 Uncertain significance 153,548,461(-) AGGCG(G/T)TAGCT nc-transcript-variant, reference, missense
rs1005436 -- 153,549,456(-) AAAAA(C/T)TCTTG intron-variant, upstream-variant-2KB
rs111252723 -- 153,551,136(+) TAAGC(C/T)GAAGT intron-variant, upstream-variant-2KB
rs111637694 -- 153,547,446(+) CCACA(A/G)GGGAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111742567 -- 153,548,800(+) TAAGC(A/G)CTCTC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A3 Gene

Variant ID Type Subtype PubMed ID
esv3587584 CNV gain 21293372
esv3587591 CNV gain 21293372
nsv1002705 CNV gain 25217958
nsv831603 CNV gain 17160897

Variation tolerance for S100A3 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A3 Gene

Disorders for S100A3 Gene

Relevant External Links for S100A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for S100A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A3 Gene

Publications for S100A3 Gene

  1. Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle. (PMID: 18083705) Kizawa K. … Heizmann C.W. (J. Biol. Chem. 2008) 3 4 22 64
  2. Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model. (PMID: 9920417) Fritz G. … Kroneck P.M.H. (Biochim. Biophys. Acta 1998) 3 4 22 64
  3. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PMID: 8341667) Engelkamp D. … Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  4. Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges. (PMID: 21377473) Unno M. … Kizawa K. (J. Mol. Biol. 2011) 3 4 64
  5. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 46 64

Products for S100A3 Gene

Sources for S100A3 Gene

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