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Aliases for S100A3 Gene

Aliases for S100A3 Gene

  • S100 Calcium Binding Protein A3 2 3
  • S100 Calcium-Binding Protein A3 2 3 4
  • S100E 3 4 6
  • Protein S100-A3 3
  • Protein S-100E 4

External Ids for S100A3 Gene

Previous HGNC Symbols for S100A3 Gene

  • S100E

Previous GeneCards Identifiers for S100A3 Gene

  • GC01M151335
  • GC01M149302
  • GC01M150344
  • GC01M150789
  • GC01M9A0063
  • GC01M9A0332
  • GC01M151786
  • GC01M124883

Summaries for S100A3 Gene

Entrez Gene Summary for S100A3 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A3 Gene

S100A3 (S100 Calcium Binding Protein A3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A3 Gene

  • Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.

Gene Wiki entry for S100A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A3 Gene

Genomics for S100A3 Gene

Regulatory Elements for S100A3 Gene

Transcription factor binding sites by QIAGEN in the S100A3 gene promoter:

Genomic Location for S100A3 Gene

153,547,329 bp from pter
153,549,372 bp from pter
2,044 bases
Minus strand

Genomic View for S100A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A3 Gene

Proteins for S100A3 Gene

  • Protein details for S100A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A3
    Protein Accession:
    Secondary Accessions:
    • D3DV51
    • Q6FGE4

    Protein attributes for S100A3 Gene

    101 amino acids
    Molecular mass:
    11713 Da
    Quaternary structure:
    • Homodimer and homotetramer for the citrullinated form.

    Three dimensional structures from OCA and Proteopedia for S100A3 Gene

neXtProt entry for S100A3 Gene

Proteomics data for S100A3 Gene at MOPED

Post-translational modifications for S100A3 Gene

  • More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.

Other Protein References for S100A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S100A3 Gene

Domains for S100A3 Gene

Gene Families for S100A3 Gene

Protein Domains for S100A3 Gene

Suggested Antigen Peptide Sequences for S100A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A3: view

Function for S100A3 Gene

Molecular function for S100A3 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A3,epidermal differentiation complex
UniProtKB/Swiss-Prot Function:
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.

Gene Ontology (GO) - Molecular Function for S100A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with S100A3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S100A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for S100A3 Gene

Localization for S100A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A3 Gene


Subcellular locations from

Jensen Localization Image for S100A3 Gene COMPARTMENTS Subcellular localization image for S100A3 gene
Compartment Confidence
cytosol 3
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for S100A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with S100A3: view

Pathways for S100A3 Gene

SuperPathways for S100A3 Gene

No Data Available

Interacting Proteins for S100A3 Gene

Gene Ontology (GO) - Biological Process for S100A3 Gene


No data available for Pathways by source for S100A3 Gene

Drugs for S100A3 Gene

(1) HMDB Compounds for S100A3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for S100A3 Gene

Compound -log(P) Hits PubMed IDs
calcium 33.5 12
zinc 11.8 4
genes like me logo Genes that share compounds with S100A3: view

Transcripts for S100A3 Gene

mRNA/cDNA for S100A3 Gene

Unigene Clusters for S100A3 Gene

S100 calcium binding protein A3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for S100A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A3 Gene

No ASD Table

Relevant External Links for S100A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A3 Gene

mRNA expression in normal human tissues for S100A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (24.8) and Skin - Sun Exposed (Lower leg) (5.8).

Protein differential expression in normal tissues for S100A3 Gene

This gene is overexpressed in Hair follicle (68.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A3 Gene

SOURCE GeneReport for Unigene cluster for S100A3 Gene Hs.557609

mRNA Expression by UniProt/SwissProt for S100A3 Gene

Tissue specificity: Skin specific, specifically expressed at the inner endocuticle of hair fibers.
genes like me logo Genes that share expressions with S100A3: view

Primer Products

In Situ Assay Products

No data available for Expression partners for S100A3 Gene

Orthologs for S100A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia S100A3 35
  • 88.78 (n)
  • 88.12 (a)
S100A3 36
  • 88 (a)
(Mus musculus)
Mammalia S100a3 35
  • 90.1 (n)
  • 90.1 (a)
S100a3 16
S100a3 36
  • 90 (a)
(Pan troglodytes)
Mammalia S100A3 35
  • 99.34 (n)
  • 100 (a)
S100A3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia S100a3 35
  • 90.76 (n)
  • 90.1 (a)
(Bos Taurus)
Mammalia S100A3 36
  • 69 (a)
(Monodelphis domestica)
Mammalia S100A3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia S100A3 36
  • 53 (a)
Species with no ortholog for S100A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A3 Gene

Gene Tree for S100A3 (if available)
Gene Tree for S100A3 (if available)

Paralogs for S100A3 Gene

(10) SIMAP similar genes for S100A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A3: view

Variants for S100A3 Gene

Sequence variations from dbSNP and Humsavar for S100A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs73026359 -- 153,551,206(+) TCCCT(C/T)ACACC upstream-variant-2KB
rs71626771 -- 153,548,757(+) AGCAT(C/T)CTACC intron-variant
rs61731550 -- 153,548,422(+) ACAGC(A/G)CCCTG reference, missense
rs61416737 -- 153,550,658(+) AGAGT(C/T)TAAGC upstream-variant-2KB
rs61265945 -- 153,549,049(+) AACTC(A/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A3 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Relevant External Links for S100A3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A3 Gene

Disorders for S100A3 Gene

(1) University of Copenhagen DISEASES for S100A3 Gene

(3) Novoseek inferred disease relationships for S100A3 Gene

Disease -log(P) Hits PubMed IDs
anaplastic astrocytoma 54.1 1
glioblastoma 35 1
tumors 0 2

Relevant External Links for S100A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with S100A3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for S100A3 Gene

Publications for S100A3 Gene

  1. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PMID: 8341667) Engelkamp D. … Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4
  2. Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle. (PMID: 18083705) Kizawa K. … Heizmann C.W. (J. Biol. Chem. 2008) 3 4 23
  3. Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model. (PMID: 9920417) Fritz G. … Kroneck P.M.H. (Biochim. Biophys. Acta 1998) 3 4 23
  4. Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc. (PMID: 7673133) FAPhr U.G. … Cox J.A. (J. Biol. Chem. 1995) 3 23
  5. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 48

Products for S100A3 Gene

Sources for S100A3 Gene

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