Free for academic non-profit institutions. Other users need a Commercial license

Aliases for S100A2 Gene

Aliases for S100A2 Gene

  • S100 Calcium Binding Protein A2 2 3 5
  • S100 Calcium-Binding Protein A2 2 3 4
  • S100L 3 4
  • CAN19 3 4
  • Protein S-100L 4

External Ids for S100A2 Gene

Previous HGNC Symbols for S100A2 Gene

  • S100L

Previous GeneCards Identifiers for S100A2 Gene

  • GC01M151349
  • GC01M149316
  • GC01M150360
  • GC01M150802
  • GC01M150346
  • GC01M151800
  • GC01M124896

Summaries for S100A2 Gene

Entrez Gene Summary for S100A2 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A2 Gene

S100A2 (S100 Calcium Binding Protein A2) is a Protein Coding gene. Diseases associated with S100A2 include chondromyxoid fibroma and lung cancer. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A2 Gene

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.

Gene Wiki entry for S100A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A2 Gene

Genomics for S100A2 Gene

Regulatory Elements for S100A2 Gene

Promoters for S100A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S100A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A2 Gene

Chromosome:
1
Start:
153,561,108 bp from pter
End:
153,567,890 bp from pter
Size:
6,783 bases
Orientation:
Minus strand

Genomic View for S100A2 Gene

Genes around S100A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A2 Gene

Proteins for S100A2 Gene

  • Protein details for S100A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29034-S10A2_HUMAN
    Recommended name:
    Protein S100-A2
    Protein Accession:
    P29034
    Secondary Accessions:
    • O00266
    • Q3KRB9
    • Q5RHS8
    • Q9BU83

    Protein attributes for S100A2 Gene

    Size:
    98 amino acids
    Molecular mass:
    11117 Da
    Quaternary structure:
    • Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    Miscellaneous:
    • This protein binds two calcium ions.
    SequenceCaution:
    • Sequence=CAA69033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100A2 Gene

neXtProt entry for S100A2 Gene

Proteomics data for S100A2 Gene at MOPED

Post-translational modifications for S100A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A2 Gene

Antibody Products

No data available for DME Specific Peptides for S100A2 Gene

Domains & Families for S100A2 Gene

Suggested Antigen Peptide Sequences for S100A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29034

UniProtKB/Swiss-Prot:

S10A2_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A2: view

Function for S100A2 Gene

Molecular function for S100A2 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A2,epidermal diffentiation complex
UniProtKB/Swiss-Prot Function:
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
UniProtKB/Swiss-Prot Induction:
By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells.

Gene Ontology (GO) - Molecular Function for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with S100A2: view
genes like me logo Genes that share phenotypes with S100A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for S100A2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A2 Gene

Localization for S100A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A2 Gene COMPARTMENTS Subcellular localization image for S100A2 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for S100A2 Gene

Pathways & Interactions for S100A2 Gene

SuperPathways for S100A2 Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with S100A2: view

Pathways by source for S100A2 Gene

1 BioSystems pathway for S100A2 Gene

Gene Ontology (GO) - Biological Process for S100A2 Gene

None

No data available for SIGNOR curated interactions for S100A2 Gene

Drugs & Compounds for S100A2 Gene

(6) Drugs for S100A2 Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olopatadine Approved Pharma Target, antagonist 0
calcium Nutra 0

(3) Additional Compounds for S100A2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A2: view

Transcripts for S100A2 Gene

Unigene Clusters for S100A2 Gene

S100 calcium binding protein A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for S100A2 Gene

GeneLoc Exon Structure for
S100A2
ECgene alternative splicing isoforms for
S100A2

Expression for S100A2 Gene

mRNA expression in normal human tissues for S100A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A2 Gene

This gene is overexpressed in Esophagus - Mucosa (x27.8), Minor Salivary Gland (x6.4), Vagina (x4.8), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for S100A2 Gene

This gene is overexpressed in Hair follicle (36.0) and Cervix (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A2 Gene



SOURCE GeneReport for Unigene cluster for S100A2 Gene Hs.516484

mRNA Expression by UniProt/SwissProt for S100A2 Gene

P29034-S10A2_HUMAN
Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes.
genes like me logo Genes that share expression patterns with S100A2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for S100A2 Gene

Orthologs for S100A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A2 35
  • 90.97 (n)
  • 90.62 (a)
S100A2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A2 35
  • 87.97 (n)
  • 85.57 (a)
S100A2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100A2 35
  • 98.63 (n)
  • 98.97 (a)
S100A2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100A2 36
  • 77 (a)
OneToOne
Species with no ortholog for S100A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A2 Gene

ENSEMBL:
Gene Tree for S100A2 (if available)
TreeFam:
Gene Tree for S100A2 (if available)

Paralogs for S100A2 Gene

genes like me logo Genes that share paralogs with S100A2: view

Variants for S100A2 Gene

Sequence variations from dbSNP and Humsavar for S100A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs8401 -- 153,561,422(-) TGACT(C/T)CCTGC utr-variant-3-prime
rs1047325 -- 153,561,551(-) GGGCA(A/G)CCTGG reference, missense
rs2071576 -- 153,565,973(-) CACAC(A/G)GGCGC upstream-variant-2KB
rs2071577 -- 153,565,687(-) AGGGA(A/G)GGGGC utr-variant-5-prime
rs1985544 -- 153,565,222(-) ccatt(C/T)tcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A2 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Variation tolerance for S100A2 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A2 Gene

HapMap Linkage Disequilibrium report
S100A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A2 Gene

Disorders for S100A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for S100A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chondromyxoid fibroma
lung cancer
  • lung cancer, protection against
oral cancer
  • malignant neoplasm of mouth
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A2

Genetic Association Database (GAD)
S100A2
Human Genome Epidemiology (HuGE) Navigator
S100A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A2
genes like me logo Genes that share disorders with S100A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A2 Gene

Publications for S100A2 Gene

  1. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. (PMID: 9481475) Wicki R. … Schaefer B.W. (Cell Calcium 1997) 3 4 23 67
  2. Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer. (PMID: 18656279) Strazisar M. … Glavac D. (Lung Cancer 2009) 3 23
  3. Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiation. (PMID: 18773213) Li Y. … Elder J.T. (Arch. Dermatol. Res. 2009) 3 23
  4. S100A2 induces metastasis in non-small cell lung cancer. (PMID: 19118029) Bulk E. … MA1ller-Tidow C. (Clin. Cancer Res. 2009) 3 23
  5. Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. (PMID: 19297317) van Dieck J. … Fersht A.R. (J. Biol. Chem. 2009) 3 23

Products for S100A2 Gene

Sources for S100A2 Gene

Back to Top

Content