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S100A2 Gene

protein-coding   GIFtS: 65

GC01M151800
S100 calcium binding protein A2
(Previous name: S100 calcium-binding protein A2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: S100L)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
CAN19 1, 2, 3
MGC111539 2
OTTHUMP00000032968 2
OTTHUMP00000032969 2
S100L 2, 3, 5
Descriptions
Protein S-100L 3
S100 calcium binding protein A2 2
S100 calcium-binding protein A2 1, 2, 3
External Ids
HGNC: 104921
Entrez Gene: 62732
UniProtKB: P290343
Ensembl: ENSG000001967547
Search outside databases for aliases for S100A2 gene

Previous GC identifers: GC01M151349 GC01M149316 GC01M150360 GC01M150802 GC01M150346

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A2:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal
rearrangements and altered expression of this gene have been implicated in breast cancer.
[provided by RefSeq]

UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
Function: May act as a modulator against excess calcium accumulation in normal human mammary
epithelial cells. May also play a role in suppressing tumor cell growth

Gene Wiki entry for S100A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A2 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151800:     (about GC identifiers)

Start:
151,800,208 bp from pter
End:
151,806,990 bp from pter
Size:
6,783 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034 (See protein sequence)
Recommended Name: Protein S100-A2  
Size: 98 amino acids; 11117 Da
Developmental stage: Preferentially expressed in normal human mammary epithelial cells as opposed
to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression
Miscellaneous: This protein binds two calcium ions (By similarity)
PDB structures from and Proteopedia :
2RGI (3D)    
Secondary accessions: O00266 Q3KRB9 Q5RHS8 Q9BU83

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005969.1  

    ENSEMBL proteins: 
    ENSP00000357700 ENSP00000357696 ENSP00000357697 ENSP00000357699 ENSP00000357698 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (S100 alpha 2)
    Human Recombinant Proteins from Abnova (S100A2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    About this table

    Antibodies for S100A2: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of S100A2
    Sigma-Aldrich Antibodies for S100A2
    R&D Systems Antibodies for S100A2
    Antibodies from Abcam (S100 alpha 2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (S100A2)
    Novus Biologicals Antibodies for S100A2

    Assays for S100A2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR018247 EF_HAND_1
     IPR011992 EF-Hand_type
     IPR013787 S100_Ca_bd_sub
     IPR018249 EF_HAND_2
     IPR001751 S100_Ca_bd


       GeneDecks  S100A2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P29034

    ProtoNet protein and cluster: P29034

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005978

                  Applied Biosystems Silencer® siRNAs for S100A2

                  Sigma-Aldrich siRNA for S100A2  
                         Sigma-Aldrich shRNA for S100A2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for S100A2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005978
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005978
                                     untagged cDNA clones in CMV expression vector (see all 2): BC002829 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: BC002829

    UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
    Function: May act as a modulator against excess calcium accumulation in normal human mammary
    epithelial cells. May also play a role in suppressing tumor cell growth
    Induction: By growth factors in early G1 phase and probably by cell-cycle regulation in S phase.
    DNA methylation probably plays a direct negative role in suppressing S100L gene expression in
    tumor cells

    Genatlas biochemistry entry for S100A2:
    S100 calcium binding protein A2,epidermal diffentiation complex

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509 calcium ion binding NAS9481475
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for S100A2
     Selected targets of p53

       GeneDecks  S100A2 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  S100A2 


    5/8 Interacting proteins for S100A2 (ENSP000003576973) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53ENSP000002693053STRING (score=.984)
    PTGS2ENSP000003564383STRING (score=.84)
    S100A8ENSP000003577223STRING (score=.806)
    HRASENSP000003733823STRING (score=.8)
    S100A14ENSP000003576893STRING (score=.75)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043542 endothelial cell migration IMP15313892
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for S100A2
    4 Novoseek chemical compound relationships for S100A2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 27.68 15 17239974 (6), 10788426 (2), 9668057 (2)
    calcium 27.22 22 9668057 (4), 12445212 (4), 17239974 (3), 16015609 (2) (see all 9)
    oligonucleotide 14.55 4 16367903 (2), 14519656 (1)
    tyrosine 0.00 3 17874182 (1), 10788426 (1), 9856822 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005978

                  Sigma-Aldrich siRNA for S100A2  
                         Sigma-Aldrich shRNA for S100A2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005978  

    REFSEQ mRNAs for S100A2 gene: 

    NM_005978.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005978  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005978
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005978
                                     untagged cDNA clones in CMV expression vector (see all 2): BC002829 

    Additional cDNA sequence: 

    AF086003.1 BC002829.2 BC105787.1 M87068.1 

    9 DOTS entries:

    DT.91778144  DT.100889674  DT.99953485  DT.91778121  DT.100889712  DT.100889706  DT.100045252  DT.121366802 
    DT.95375649 

    24/133 AceView cDNA sequences (see all 133 ):

    BM549544 CD365047 BI335835 H64656 BI085124 BM550262 AA459074 BM980620 
    BM979834 CA435200 AA458884 AA594885 BM976343 BF149223 C00271 BX119419 
    AA593632 C00151 AI436747 CA748677 BM839923 NM_005978 AA586847 AA596012 

    highest scoring ESTs for S100A2:

    AI539439 M87068 AW393078 BC002829 BE514982 BE614814 BG164098 BG167897 BG495888 BG776770 

    Unigene Cluster for S100A2:

    S100 calcium binding protein A2
    Hs.516484  [show with all ESTs]
    Unigene Representative Sequence: BU589956


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for S100A2

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
    SP1:                                    
    SP2:                          -         
    SP3:                          -         
    SP4:              -           -         

    About this scheme

    ECgene alternative splicing isoforms for S100A2

    5 Ensembl transcripts including schematic representations:
    ENST00000368711  ENST00000368707  ENST00000368708  ENST00000368710  ENST00000368709  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    S100A2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for S100A2

    1 / 2 / 3

    4 probe-sets matching S100A2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35726_at2, 3 U95-A 1 1.00 1.00 0.98 0.80 AI539439 1.00 1.00 1.00 1
    2027_at2, 3 U95-A 1 1.00 1.00 0.91 1.23 M87068 1.00 1.00 1.00 1

    204268_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005978 0.60 1.00 0.82 1

    204268_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  S100A2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GATCTCTTGG

    SOURCE GeneReport for Unigene cluster: Hs.516484

    Expression variation in blood from EXPOLDB for S100A2

    UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
    Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells
    and keratinocytes

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for S100A2 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    S100A21   -- S100 calcium binding protein A2 87.97(n)
    85.57(a)
    612326  XM_850065.1  XP_855158.1 
    chimpanzee
    (Pan troglodytes)
    S100A21   -- S100 calcium binding protein A2 98.63(n)
    98.97(a)
    457321  XM_513816.2  XP_513816.1 
    cow
    (Bos taurus)
    S100A21   -- S100 calcium binding protein A2 90.97(n)
    90.62(a)
    509860  NM_001034367.1  NP_001029539.1 
    mouse
    (Mus musculus)
    S100a25 3 S100 calcium binding protein A2   -- AI448493 
    zebrafish
    (Danio rerio)
    zgc:1107711   -- zgc:110771 58.54(n)
    46.34(a)
    541368  NM_001013495.1  NP_001013513.1 
    About this table        Species with no ortholog for S100A2

    ENSEMBL Gene Tree for S100A2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for S100A2 gene
    S100A62  S100A32  S100A12  S100Z2  S100A52  S100A42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/91 NCBI SNPs in S100A2 are shown (see all 91 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 14)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs10473251,2
    C,F,H151800651(-) GGGCAG/ACCTGG 1 N/S mis1 ese313Minor allele frequency- A:0.17MN NA EU EA WA 1218
    rs84011,2
    C,F,H151800522(-) TGACTC/TCCTGC 1 -- ut317Minor allele frequency- T:0.35NA EU EA WA 556
    --
    rs20715761,2
    C,F151805073(-) CACACA/GGGCGC 1 -- ng311Minor allele frequency- G:0.41EA 1500
    --
    rs168292841,2
    F,H151806294(+) CAGGGC/TCTTCC 1 -- ng317Minor allele frequency- T:0.01NA EU EA WA 532
    rs24781471,2
    C,H151805389(-) CTACTC/TGGGAC 1 -- ng314Minor allele frequency- T:0.00EU EA WA 418
    --
    rs168292851,2
    F,H151806921(+) TAGAGA/CATTCT 1 -- ng317Minor allele frequency- C:0.10NA EU EA WA 552
    rs28574231,2
    H151805619(-) CTGGGC/GTCTGA 1 -- ng312Minor allele frequency- G:0.00EU WA 240
    --
    rs67028911,2
    A151806810(+) AACCCA/CCCCTT 1 -- ng31 trp30--------
    --
    rs27658551,2
    H151805985(+) GGCAGG/TAGGAT 1 -- ng314Minor allele frequency- T:0.00EU EA WA 418
    rs22338681,2
    H151802970(-) GATGTG/CCAGTT 1 S/C mis14Minor allele frequency- C:0.00EU EA WA 390
    About this table

    HapMap Linkage Disequilibrium images for S100A2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 176993

    10/23 Novoseek disease relationships for S100A2 gene (see all 23 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 57.05 19 11304580 (3), 16273244 (3), 16908593 (2), 11956617 (2) (see all 11)
    adenocarcinoma 44.40 11 17032501 (2), 17940995 (1), 16015609 (1), 18656279 (1) (see all 7)
    nsclc 43.86 23 19118029 (6), 15800916 (3), 18656279 (2), 11691825 (2) (see all 7)
    tumors 42.08 63 17032501 (4), 11956617 (4), 9481475 (3), 11304580 (3) (see all 27)
    oral cancer 35.44 3 15792606 (3)
    melanoma 29.84 13 9291441 (4), 12652189 (2), 9162739 (2), 9274623 (2) (see all 5)
    cancer lung 29.43 5 15800916 (1), 19118029 (1), 18656279 (1), 11691825 (1)
    adenocarcinoma lung 27.08 6 16367903 (4), 16232198 (1)
    cancer 27.03 9 11813862 (1), 17289885 (1), 12506178 (1), 16908593 (1) (see all 7)
    carcinoma papillary 25.79 2 15842639 (2)
    About this table

    Genetic Association Database: S100A2
    Human Genome Epidemiology Navigator: S100A2 (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/102 PubMed articles for S100A2 gene (see all 102 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6273 HGNC: 10492 AceView: S100A2 Ensembl:ENSG00000196754 euGenes: HUgn6273
    ECgene: S100A2 H-InvDB: S100A2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for S100A2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for S100A2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for S100A2 Antibodies for S100A2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for S100A2 Browse small molecules at Sigma-Aldrich
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