Aliases for S100A2 Gene
External Ids for S100A2 Gene
Previous HGNC Symbols for S100A2 Gene
Previous GeneCards Identifiers for S100A2 Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for S100A2 Gene
S100A2 (S100 Calcium Binding Protein A2) is a Protein Coding gene. Diseases associated with S100A2 include lung squamous cell carcinoma and chondromyxoid fibroma. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A6.
UniProtKB/Swiss-Prot for S100A2 Gene
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.