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Aliases for S100A2 Gene

Aliases for S100A2 Gene

  • S100 Calcium Binding Protein A2 2 3
  • S100 Calcium-Binding Protein A2 2 3 4
  • S100L 3 4 6
  • CAN19 3 4
  • Protein S100-A2 3
  • Protein S-100L 4

External Ids for S100A2 Gene

Previous Symbols for S100A2 Gene

  • S100L

Summaries for S100A2 Gene

Entrez Gene Summary for S100A2 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A2 Gene

S100A2 (S100 Calcium Binding Protein A2) is a Protein Coding gene. Diseases associated with S100A2 include pancreatic cancer and breast cancer. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A2 Gene

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.

Gene Wiki entry for S100A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A2 Gene

Genomics for S100A2 Gene

Genomic Location for S100A2 Gene

153,561,108 bp from pter
153,567,890 bp from pter
6,783 bases
Minus strand

Genomic View for S100A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A2 Gene

Regulatory Elements for S100A2 Gene

Proteins for S100A2 Gene

  • Protein details for S100A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A2
    Protein Accession:
    Secondary Accessions:
    • O00266
    • Q3KRB9
    • Q5RHS8
    • Q9BU83

    Protein attributes for S100A2 Gene

    98 amino acids
    Molecular mass:
    11117 Da
    Quaternary structure:
    • Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    • This protein binds two calcium ions.
    • Sequence=CAA69033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for S100A2 Gene

neXtProt entry for S100A2 Gene

Proteomics data for S100A2 Gene at MOPED

Post-translational modifications for S100A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A2 Gene

No data available for DME Specific Peptides for S100A2 Gene

Domains for S100A2 Gene

Gene Families for S100A2 Gene

  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins


  • Contains 2 EF-hand domains.:
    • P29034
  • Belongs to the S-100 family.:
    • P29034
genes like me logo Genes that share domains with S100A2: view

Function for S100A2 Gene

Molecular function for S100A2 Gene

GENATLAS Biochemistry: S100 calcium binding protein A2,epidermal diffentiation complex
UniProtKB/Swiss-Prot Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
UniProtKB/Swiss-Prot Induction: By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells.

Gene Ontology (GO) - Molecular Function for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 9481475
GO:0005515 protein binding IPI 20188096
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with S100A2: view

miRNA for S100A2 Gene

miRTarBase miRNAs that target S100A2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for S100A2 Gene

Localization for S100A2 Gene

Subcellular locations from

Jensen Localization Image for S100A2 Gene COMPARTMENTS Subcellular localization image for S100A2 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with S100A2: view

Pathways for S100A2 Gene

SuperPathways for S100A2 Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with S100A2: view

Pathways by source for S100A2 Gene

1 BioSystems pathway for S100A2 Gene

Gene Ontology (GO) - Biological Process for S100A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043542 endothelial cell migration IMP 15313892
genes like me logo Genes that share ontologies with S100A2: view

Compounds for S100A2 Gene

(1) HMDB Compounds for S100A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for S100A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
113806-05-6 target antagonist

(8) Novoseek inferred chemical compound relationships for S100A2 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 51 4
calcium 32.8 19
zinc 29.9 11
oligonucleotide 13 3
etoposide 4.4 5
genes like me logo Genes that share compounds with S100A2: view

Transcripts for S100A2 Gene

mRNA/cDNA for S100A2 Gene

Unigene Clusters for S100A2 Gene

S100 calcium binding protein A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP2: -
SP3: -
SP4: - -

Relevant External Links for S100A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A2 Gene

mRNA expression in normal human tissues for S100A2 Gene

mRNA differential expression in normal tissues according to GTEx for S100A2 Gene

This gene is overexpressed in Esophagus - Mucosa (27.8), Minor Salivary Gland (6.4), Vagina (4.8), and Skin - Not Sun Exposed (Suprapubic) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A2 Gene

SOURCE GeneReport for Unigene cluster for S100A2 Gene Hs.516484

mRNA Expression by UniProt/SwissProt for S100A2 Gene

Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes.
genes like me logo Genes that share expressions with S100A2: view

Orthologs for S100A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A2 36
  • 98.63 (n)
  • 98.97 (a)
S100A2 37
  • 69 (a)
(Bos Taurus)
Mammalia S100A2 36
  • 90.97 (n)
  • 90.62 (a)
S100A2 37
  • 90 (a)
(Canis familiaris)
Mammalia S100A2 36
  • 87.97 (n)
  • 85.57 (a)
S100A2 37
  • 86 (a)
(Mus musculus)
Mammalia S100a2 16
(Ornithorhynchus anatinus)
Mammalia S100A2 37
  • 77 (a)
Species with no ortholog for S100A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A2 Gene

Gene Tree for S100A2 (if available)
Gene Tree for S100A2 (if available)

Paralogs for S100A2 Gene

Selected SIMAP similar genes for S100A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with S100A2: view

Variants for S100A2 Gene

Sequence variations from dbSNP and Humsavar for S100A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8401 -- 153,561,422(-) TGACT(C/T)CCTGC utr-variant-3-prime
rs1047325 -- 153,561,551(-) GGGCA(A/G)CCTGG missense, reference
rs1985544 -- 153,565,222(-) ccatt(C/T)tcctg intron-variant
rs1985545 -- 153,565,221(-) cattc(C/T)cctgc intron-variant
rs2071576 -- 153,565,973(-) CACAC(A/G)GGCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S100A2 Gene

Variant ID Type Subtype PubMed ID
nsv831603 CNV Gain 17160897

Relevant External Links for S100A2 Gene

HapMap Linkage Disequilibrium report

Disorders for S100A2 Gene

(1) University of Copenhagen DISEASES for S100A2 Gene

(23) Novoseek inferred disease relationships for S100A2 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 57.7 18
nsclc 44.8 20
adenocarcinoma 44.6 8
tumors 41.5 50
oral cancer 33.3 3

Relevant External Links for S100A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with S100A2: view

No data available for UniProtKB/Swiss-Prot for S100A2 Gene

Publications for S100A2 Gene

  1. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. (PMID: 9481475) Wicki R. … Schaefer B.W. (Cell Calcium 1997) 3 4 23
  2. S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis. (PMID: 11260185) Stoll S.W. … Elder J.T. (Clin. Exp. Dermatol. 2001) 3 23 49
  3. Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer. (PMID: 18656279) Strazisar M. … Glavac D. (Lung Cancer 2009) 3 23 49
  4. Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. (PMID: 18669640) Shimamoto S. … Kobayashi R. (J. Biol. Chem. 2008) 3 23
  5. Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiation. (PMID: 18773213) Li Y. … Elder J.T. (Arch. Dermatol. Res. 2009) 3 23

Products for S100A2 Gene

  • antibodies-online proteins for S100A2
  • antibodies-online antibodies for S100A2
  • antibodies-online kits for S100A2

Sources for S100A2 Gene

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