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Aliases & Descriptions for S100A2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CAN19 1, 2, 3 | | MGC111539 2 | | OTTHUMP00000032968 2 | | OTTHUMP00000032969 2 | | S100L 2, 3, 5 |
| | | Descriptions |
|---|
| Protein S-100L 3 | | S100 calcium binding protein A2 2 | | S100 calcium-binding protein A2 1, 2, 3 |
|
| | Search outside databases for aliases for S100A2 genePrevious GC identifers: GC01M151349 GC01M149316 GC01M150360 GC01M150802 GC01M150346 |
Summaries for S100A2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for S100A2: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq] UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034Function: May act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. May also play a role in suppressing tumor cell growthGene Wiki entry for S100A2 |
Genomic Location for S100A2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the S100A2 gene 
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21S100A2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M151800:
(about GC identifiers)
Start:
|
151,800,208 bp from pter |
End:
|
151,806,990 bp from pter |
Size:
|
6,783 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for S100A2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034 (See
protein sequence)Recommended Name: Protein S100-A2 Size: 98 amino acids; 11117 Da
Developmental stage: Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression
Miscellaneous: This protein binds two calcium ions (By similarity)
PDB structures from and Proteopedia :2RGI (3D)
 
Secondary accessions: O00266 Q3KRB9 Q5RHS8 Q9BU83Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005969.1
ENSEMBL proteins: ENSP00000357700 ENSP00000357696 ENSP00000357697 ENSP00000357699 ENSP00000357698
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for S100A2: Assays for S100A2: | Protein
Domains/ Families for S100A2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P29034
ProtoNet protein and cluster: P29034 1 Blocks protein family: IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034Similarity: Belongs to the S-100 familySimilarity: Contains 2 EF-hand domains | Gene Function for S100A2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005978
Applied Biosystems Silencer® siRNAs for S100A2
Sigma-Aldrich siRNA for S100A2  Sigma-Aldrich shRNA for S100A2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005978                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005978                                  untagged cDNA clones in CMV expression vector (see all 2): BC002829 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC002829
UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034Function: May act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. May also play a role in suppressing tumor cell growthInduction: By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cellsGenatlas biochemistry entry for S100A2:S100 calcium binding protein A2,epidermal diffentiation complex1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for S100A2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for S100A2 
5/8 Interacting proteins for S100A2 (ENSP000003576973) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for S100A2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for S100A2 4 Novoseek chemical compound relationships for S100A2 gene
About this table
|
Transcripts for S100A2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005978
Sigma-Aldrich siRNA for S100A2  Sigma-Aldrich shRNA for S100A2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005978 REFSEQ mRNAs for S100A2 gene: NM_005978.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005978               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005978                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005978                                  untagged cDNA clones in CMV expression vector (see all 2): BC002829  Additional cDNA sequence: AF086003.1 BC002829.2 BC105787.1 M87068.1 9 DOTS entries: DT.91778144 DT.100889674 DT.99953485 DT.91778121 DT.100889712 DT.100889706 DT.100045252 DT.121366802 DT.95375649 24/133 AceView cDNA sequences (see all 133
):BM549544 CD365047 BI335835 H64656 BI085124 BM550262 AA459074 BM980620 BM979834 CA435200 AA458884 AA594885 BM976343 BF149223 C00271 BX119419 AA593632 C00151 AI436747 CA748677 BM839923 NM_005978 AA586847 AA596012
highest scoring ESTs for S100A2:AI539439 M87068 AW393078 BC002829 BE514982 BE614814 BG164098 BG167897 BG495888 BG776770 Unigene Cluster for S100A2: S100 calcium binding protein A2 Hs.516484 [show with all ESTs]Unigene Representative Sequence: BU589956
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for S100A2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |
| SP4: | |   | |   | - |   | |   | - |   | |   |
About this scheme
ECgene alternative splicing isoforms for S100A2
5 Ensembl transcripts including schematic representations: ENST00000368711
ENST00000368707
ENST00000368708
ENST00000368710
ENST00000368709
|
Expression for S100A2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| S100A2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for S100A2
1 / 2 / 3 4 probe-sets matching S100A2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GATCTCTTGG
SOURCE GeneReport for Unigene cluster: Hs.516484
Expression variation in blood from EXPOLDB for S100A2 UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes |
Orthologs for S100A2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for S100A2 gene from 5 species
About this table Species with no ortholog for S100A2
ENSEMBL Gene Tree for S100A2 | Paralogs for S100A2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for S100A2 gene
- S100A62 S100A32 S100A12 S100Z2 S100A52 S100A42
|
SNPs/Variants for S100A2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for S100A2 (up to first 250kb)
|
Disorders & Mutations for S100A2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 176993
10/23 Novoseek disease relationships for S100A2 gene (see all 23
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma squamous cell |
57.05 |
19 |
11304580 (3), 16273244 (3), 16908593 (2), 11956617 (2) (see all 11) |
| adenocarcinoma |
44.40 |
11 |
17032501 (2), 17940995 (1), 16015609 (1), 18656279 (1) (see all 7) |
| nsclc |
43.86 |
23 |
19118029 (6), 15800916 (3), 18656279 (2), 11691825 (2) (see all 7) |
| tumors |
42.08 |
63 |
17032501 (4), 11956617 (4), 9481475 (3), 11304580 (3) (see all 27) |
| oral cancer |
35.44 |
3 |
15792606 (3) |
| melanoma |
29.84 |
13 |
9291441 (4), 12652189 (2), 9162739 (2), 9274623 (2) (see all 5) |
| cancer lung |
29.43 |
5 |
15800916 (1), 19118029 (1), 18656279 (1), 11691825 (1) |
| adenocarcinoma lung |
27.08 |
6 |
16367903 (4), 16232198 (1) |
| cancer |
27.03 |
9 |
11813862 (1), 17289885 (1), 12506178 (1), 16908593 (1) (see all 7) |
| carcinoma papillary |
25.79 |
2 |
15842639 (2) |
About this table
Genetic Association Database: S100A2 Human Genome Epidemiology Navigator: S100A2 (2 documents)
|
Medical News for S100A2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for S100A2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/102 PubMed articles for S100A2 gene (see all 102
):- Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. (PubMed id 9481475)1, 3, 4 Wicki R.... Schaefer B.W. (1997)
- S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis. (PubMed id 11260185)1, 3, 6 Stoll S.W....Elder J.T. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)2, 3 Engelkamp D.... Heizmann C.W. (1993)
- Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. (PubMed id 1372446)3, 4 Lee S.W.... Sager R. (1992)
- Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)3, 4 Rasmussen H.H....Vandekerckhove J. (1992)
- Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. (PubMed id 12445212)1, 3 Zhang T....Elder J.T. (2002)
- Biochemical characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking. (PubMed id 10951287)1, 3 Deshpande R....Elder J.T. (2000)
- S100A2 induces metastasis in non-small cell lung cancer. (PubMed id 19118029)1, 3 Bulk E....MA1ller-Tidow C. (2009)
|
Search for S100A2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing S100A2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing S100A2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing S100A2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for S100A2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for S100A2:

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