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S100A2 Gene

protein-coding   GIFtS: 65
GCID: GC01M153533

S100 Calcium Binding Protein A2

(Previous name: S100 calcium-binding protein A2)
(Previous symbol: S100L)
  See S100A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A21 2
S100L1 2 3 5
S100 Calcium-Binding Protein A21 2 3
CAN192 3
Protein S100-A22
Protein S-100L3

External Ids:    HGNC: 104921   Entrez Gene: 62732   Ensembl: ENSG000001967547   OMIM: 1769935   UniProtKB: P290343   

Export aliases for S100A2 gene to outside databases

Previous GC identifers: GC01M151349 GC01M149316 GC01M150360 GC01M150802 GC01M150346 GC01M151800 GC01M124896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A2 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor
suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in
breast cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100A2 Gene:
S100A2 (S100 calcium binding protein A2) is a protein-coding gene. Diseases associated with S100A2 include pilomatrixoma, and chondromyxoid fibroma. GO annotations related to this gene include identical protein binding and calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function
by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many
physiological processes. May also play a role in suppressing tumor cell growth

Gene Wiki entry for S100A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A2 gene promoter:
         Egr-2   p53   FOXJ2 (long isoform)   FOXJ2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A2 promoter sequence
   Search Chromatin IP Primers for S100A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153533:  view genomic region     (about GC identifiers)

Start:
153,533,584 bp from pter      End:
153,540,366 bp from pter
Size:
6,783 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034 (See protein sequence)
Recommended Name: Protein S100-A2  
Size: 98 amino acids; 11117 Da
Subunit: Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is
calcium-dependent and modulates PPP5C activity
Developmental stage: Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived
ones. The level of S100L was shown to correlate inversely with tumor progression
Miscellaneous: This protein binds two calcium ions (By similarity)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=CAA69033.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for S100A2:
2RGI (3D)        4DUQ (3D)    
Secondary accessions: O00266 Q3KRB9 Q5RHS8 Q9BU83

Explore the universe of human proteins at neXtProt for S100A2: NX_P29034

Explore proteomics data for S100A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See S100A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005969.1  
    ENSEMBL proteins: 
     ENSP00000357697   ENSP00000473260   ENSP00000473489   ENSP00000357699   ENSP00000357698  
     ENSP00000357696  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    Selected InterPro protein domains (see all 6):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR028496 S100-A2/S100-A4
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P29034

    ProtoNet protein and cluster: P29034

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Find genes that share domains with S100A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S10A2_HUMAN, P29034
    Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function
    by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many
    physiological processes. May also play a role in suppressing tumor cell growth
    Induction: By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation
    probably plays a direct negative role in suppressing S100L gene expression in tumor cells

         Genatlas biochemistry entry for S100A2:
    S100 calcium binding protein A2,epidermal diffentiation complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS9481475
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding IPI16189514
         
    Find genes that share ontologies with S100A2           About GenesLikeMe


    Animal Models:
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    Block miRNA regulation of human, mouse, rat S100A2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate S100A2:
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    SwitchGear 3'UTR luciferase reporter plasmidS100A2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with S100A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S100A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53
    2Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for S100A2
        Direct p53 effectors



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for S100A2
    Interactions:

        GeneGlobe Interaction Network for S100A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for S100A2 (P290341, 2, 3 ENSP000003576974) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FKBP4Q027901, 2, 3, ENSP000000010084EBI-752230,EBI-1047444 MINT-7710374 MINT-7710476 MINT-7710432 I2D: score=1 STRING: ENSP00000001008
    TP53P046371, 2, 3, ENSP000002693054EBI-752230,EBI-366083 MINT-7905347 MINT-7905185 I2D: score=3 STRING: ENSP00000269305
    MDM2Q009871, 2, 3, ENSP000004172814EBI-752230,EBI-389668 MINT-7905238 MINT-7905090 I2D: score=2 STRING: ENSP00000417281
    AREGP155142, 3MINT-7256654 I2D: score=1 
    KPNA2P522921, 2, 3, ENSP000003324554EBI-752230,EBI-349938 MINT-8044917 MINT-8045244 MINT-8045302 MINT-8044951 MINT-8045267 I2D: score=1 STRING: ENSP00000332455
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043542endothelial cell migration IMP15313892

    Find genes that share ontologies with S100A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for S100A2 (S10A2)

    1 HMDB Compound for S100A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for S100A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olopatadine-- 113806-05-6targetantagonist11944917

    8 Novoseek inferred chemical compound relationships for S100A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 51 5 17785578 (3), 11691825 (1)
    calcium 32.8 23 9668057 (4), 12445212 (4), 17239974 (3), 16015609 (2) (see all 10)
    zinc 29.9 16 17239974 (6), 10788426 (2), 9668057 (2), 19386136 (1)
    oligonucleotide 13 4 16367903 (2), 14519656 (1)
    etoposide 4.4 5 10094469 (4), 11005251 (1)
    tyrosine 0 3 17874182 (1), 10788426 (1), 9856822 (1)
    cysteine 0 4 10788426 (2), 10951287 (1)
    h2o2 0 7 12445212 (3), 10951287 (1)



    Find genes that share compounds with S100A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for S100A2 gene: 
    NM_005978.3  

    Unigene Cluster for S100A2:

    S100 calcium binding protein A2
    Hs.516484  [show with all ESTs]
    Unigene Representative Sequence: BU589956
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368708(uc001fcb.3) ENST00000487430 ENST00000497140 ENST00000368710
    ENST00000368709 ENST00000368707
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate S100A2:
    hsa-miR-561 hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidS100A2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat S100A2

    Additional mRNA sequence: 

    AF086003.1 BC002829.2 BC105787.1 M87068.1 

    9 DOTS entries:

    DT.91778144  DT.100889674  DT.99953485  DT.100889712  DT.100889706  DT.91778121  DT.100045252  DT.121366802 
    DT.95375649 

    Selected AceView cDNA sequences (see all 133):

    H64656 BI335835 AA586847 AI436747 BF149223 BM550262 AA594885 AA593632 
    BM976343 AA458884 NM_005978 AF086003 CA435200 BI085124 BM980620 CA748677 
    CD365047 BM979834 AA596012 BM839923 BM549544 C00151 AA161019 BX119419 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for S100A2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
    SP1:                                    
    SP2:                          -         
    SP3:                          -         
    SP4:              -           -         


    ECgene alternative splicing isoforms for S100A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S100A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTCTTGG
    S100A2 Expression
    About this image

    S100A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S100A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516484

    UniProtKB/Swiss-Prot: S10A2_HUMAN, P29034
    Tissue specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for S100A2 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a25 S100 calcium binding protein A2   --   3 90590247 


    ENSEMBL Gene Tree for S100A2 (if available)
    TreeFam Gene Tree for S100A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S100A2 gene
    S100A112  S100A62  S100A12  S100A122  S100B2  S100A42  S100A32  S100A102  
    S100Z2  S100P2  S100A52  S100A92  
    Selected SIMAP similar genes for S100A2 using alignment to 3 protein entries:     S10A2_HUMAN (see all proteins) (see all similar genes):
    S100A4    S100A5    S100A6    S100A1    S100Z    S100B
    S100A9    S100P    HRNR    S100A16    S100A3    FLG2
    S100A11    S100A10    S100A12    S100A13    S100G    RPTN

    Find genes that share paralogs with S100A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S100A2 (see all 175)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159684451,2
    C,F--153533183(+) CAGGTT/GCAAGC 1 -- ds50011Minor allele frequency- G:0.10NA 120
    rs1432363801,2
    --153533231(+) CAGGCA/GTGTAC 1 -- ds50010--------
    rs1390818691,2
    --153533385(+) TGCTCA/GGTCTA 1 -- ds50010--------
    rs1815539001,2
    --153533438(+) TAATTA/CATATC 1 -- ds50010--------
    rs1862778341,2
    --153533501(+) CTGTCC/TTTTAT 1 -- ds50010--------
    rs752827961,2
    C--153533840(+) AAGTTC/TATTGA 1 -- ut310--------
    rs22338691,2
    C--153533893(-) TCCTGC/GCATGG 1 -- ut310--------
    rs84011,2
    C,F,H--153533898(-) TGACTT/CCCTGC 1 -- ut3125Minor allele frequency- C:0.18NA NS EA WA CSA EU 3583
    rs1440546051,2
    C,F--153533923(+) GGGTCG/AGTCTG 2 /R /* stg11Minor allele frequency- A:0.00NA 4552
    rs413008571,2
    C--153534013(+) GTCACC/TGTTCT 2 S G mis10--------

    HapMap Linkage Disequilibrium report for S100A2 (153533584 - 153540366 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for S100A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831603CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176993    OMIM disorders: --

    8 diseases for S100A2:    
    About MalaCards
    pilomatrixoma    chondromyxoid fibroma    lung squamous cell carcinoma    oral cancer
    gastric adenocarcinoma    pancreatic cancer    non-small cell lung carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for S100A2:
    Carcinoma

    Find genes that share disorders with S100A2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for S100A2 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 57.7 20 11304580 (3), 16273244 (3), 16908593 (2), 11956617 (2) (see all 12)
    nsclc 44.8 28 19118029 (6), 15800916 (3), 19238334 (3), 18656279 (2) (see all 8)
    adenocarcinoma 44.6 11 17032501 (2), 17940995 (1), 16015609 (1), 18656279 (1) (see all 7)
    tumors 41.5 66 17032501 (4), 11956617 (4), 9481475 (3), 11304580 (3) (see all 28)
    oral cancer 33.3 3 15792606 (3)
    pancreatic cancer 31.8 7 17940995 (4), 17200013 (3)
    melanoma 31.6 15 9291441 (4), 12652189 (2), 9162739 (2), 9274623 (2) (see all 6)
    cancer 27.5 9 11813862 (1), 17289885 (1), 12506178 (1), 16908593 (1) (see all 7)
    cancer lung 27.3 5 15800916 (1), 19118029 (1), 18656279 (1), 11691825 (1)
    adenocarcinoma lung 24.6 6 16367903 (4), 16232198 (1)

    Genetic Association Database (GAD): S100A2
    Human Genome Epidemiology (HuGE) Navigator: S100A2 (4 documents)

    Export disorders for S100A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S100A2 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with S100A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. (PubMed id 9481475)1, 2, 9 Wicki R.... Schaefer B.W. (Cell Calcium 1997)
    2. S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis. (PubMed id 11260185)1, 4, 9 Stoll S.W....Elder J.T. (Clin. Exp. Dermatol. 2001)
    3. Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer. (PubMed id 18656279)1, 4, 9 Strazisar M....Glavac D. (Lung Cancer 2009)
    4. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PubMed id 20188096)1, 2 Shimamoto S.... Kobayashi R. (FEBS Lett. 2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    6. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. (PubMed id 8341667)1, 3 Engelkamp D.... Heizmann C.W. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    10. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. (PubMed id 1372446)1, 2 Lee S.W.... Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6273 HGNC: 10492 AceView: S100A2 Ensembl:ENSG00000196754 euGenes: HUgn6273
    ECgene: S100A2 H-InvDB: S100A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for S100A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S100A2 gene:
    Search GeneIP for patents involving S100A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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