S100A16 Gene

Aliases
for S100A16 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M9A0123 GC01M9A0392 GC01M150393 GC01M151845 GC01M124942

Summaries
for S100A16 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for S100A16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_004487.20  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: S100A16 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A16

S100A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153579:  view genomic region     (about GC identifiers)

Proteins
for S100A16 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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3 PDB 3D structures from and Proteopedia for S100A16:

2L50 (3D)        2L51 (3D)        3NXA (3D)    

Explore the universe of human proteins at neXtProt for S100A16: NX_Q96FQ6

Explore proteomics data for S100A16 at MOPED

Post-translational modifications: 

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Domains /
Families
for S100A16 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96FQ6

Find genes that share domains with S100A16           About GenesLikeMe

Function
for S100A16 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for S100A16

miRNA Products:		miRTarBase miRNAs that target S100A16: hsa-mir-1 (MIRT024074), hsa-mir-193b-3p (MIRT016530)
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		hsa-miR-4310
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Gene Editing Products:

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A16

Localization
for S100A16 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	5
nucleus	5
plasma membrane	4
cytoskeleton	1
extracellular	1

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Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

Pathways & Interactions
for S100A16 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for S100A16 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for S100A16 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for S100A16 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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S100A16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCAGGAGCA

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Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
Hindgut
Germ Cells (Reproductive System)
Primordial germ cell-like cells
Ovary (Reproductive System)
Ovarian Somatic Cells Ovigerous Cord
Endothelium (Cardiovascular System)
Extraembryonic Angioblasts Extraembryonic Capillary Plexus
Extraembryonic Mesoderm (Extraembryonic Tissues)
Extraembryonic Angioblasts Extraembryonic Capillary Plexus

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A16

Orthologs
for S100A16 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for S100A16 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for S100A16 gene

13 SIMAP similar genes for S100A16 using alignment to 1 protein entry:     S10AG_HUMAN:

S100B    S100Z    S100A4    S100P    S100A13    S100A10

S100A6    HRNR    S100A12    S100A2    S100A11    S100A14

S100A8

Find genes that share paralogs with S100A16           About GenesLikeMe

Genomic Variants
for S100A16 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for S100A16 (see all 158)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1164490051,2	C,F	--	153578987(+)	CTGTAC/GAGGGG	1	--	int1		1		WA	118
rs557677311,2	C	--	153579068(+)	AAAAA-/A/AA           GACTA	1	--	int1		1		NA	2
rs285484771,2	C	--	153579086(+)	TGGTCC/GCTCTC	1	--	int1		2		NA	4
rs1808800301,2		--	153579109(+)	AGTGAA/GGACTA	1	--	int1		0	--	--	--	--
rs1385056391,2		--	153579459(+)	CAACAA/GGAGGA	1	--	ut31		0	--	--	--	--
rs1417280411,2	C	--	153579817(+)	TGAGA-/CCCCCC	1	--	ut31		0	--	--	--	--
rs1159179751,2	C,F	--	153579864(+)	AGGGAC/ACCCAG	1	--	ut31		1		WA	118
rs2015957331,2		--	153580051(+)	TTTGGC/GGATGG	2	P A	mis1		0	--	--	--	--
rs1473575461,2	C,F	--	153580052(+)	TTGGCG/AATGGG	2	/I	syn1		2		NA EU	5875
rs2010042641,2		--	153580060(+)	GGGGCC/TGGTGA	2	S G	mis1		0	--	--	--	--

HapMap Linkage Disequilibrium report for S100A16 (153579362 - 153585621 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for S100A16: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing S100A16

DNA2.0 Custom Variant and Variant Library Synthesis for S100A16

Disorders / Diseases
for S100A16 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for S100A16 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Structural characterization of human S100A16, a low-affinity calcium binder. (PubMed id 21046186)^{1, 2} Babini E....Parigi G. (J. Biol. Inorg. Chem. 2011)
2. S100A16, a novel calcium-binding protein of the EF-hand superfamily. (PubMed id 17030513)^{1, 2} Sturchler E.... Heizmann C.W. (J. Biol. Chem. 2006)
3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)^{1, 3} Reddy P.H.... Tagle D.A. (Genomics 1997)
6. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
7. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)¹ Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
8. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

External Searches for S100A16 gene

Genome Databases showing S100A16 gene

Other Databases showing S100A16 gene

Specialized Databases showing S100A16 gene

Products
for S100A16 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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