S100A16 Gene(Protein Coding)

S100 Calcium Binding Protein A16

GCID:: GC01M153579

GIFtS:: 54

Genes Participants

Aliases for S100A16 Gene

S100 Calcium Binding Protein A16 ² ³ ⁵
Aging-Associated Gene 13 Protein ³ ⁴
S100 Calcium-Binding Protein A16 ³ ⁴
Protein S100-F ³ ⁴
S100F ³ ⁴
Aging-Associated Protein 13 ³
DT1P1A7 ³
AAG13 ³

External Ids for S100A16 Gene

HGNC: 20441
Entrez Gene: 140576
Ensembl: ENSG00000188643
UniProtKB: Q96FQ6

Previous GeneCards Identifiers for S100A16 Gene

GC01M9A0123
GC01M9A0392
GC01M150393
GC01M151845
GC01M124942

Export aliases for S100A16 gene to outside databases

Summaries for S100A16 Gene

GeneCards Summary for S100A16 Gene

S100A16 (S100 Calcium Binding Protein A16) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot for S100A16 Gene

S10AG_HUMAN,Q96FQ6

Calcium-binding protein. Binds one calcium ion per monomer.

Gene Wiki entry for S100A16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A16 Gene

Genomics for S100A16 Gene

Regulatory Elements for S100A16 Gene

Enhancers for S100A16 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around S100A16 on UCSC Golden Path with GeneCards custom track

Promoters for S100A16 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters

ENSRs around S100A16 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the S100A16 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for S100A16 Gene

Chromosome:: 1

Start:: 153,606,886 bp from pter
End:: 153,613,145 bp from pter

Size:: 6,260 bases
Orientation:: Minus strand

Genomic View for S100A16 Gene

Genes around S100A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

1q21.3 by Ensembl
1q21 by Entrez Gene
1q21 by HGNC

S100A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for S100A16 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for S100A16 Gene

Proteins for S100A16 Gene

Protein details for S100A16 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q96FQ6-S10AG_HUMAN

Recommended name:

Protein S100-A16

Protein Accession:

Q96FQ6

Secondary Accessions:
- A8K439
- D3DV52
- Q5RHS6
Protein attributes for S100A16 Gene
Size:

103 amino acids

Molecular mass:

11801 Da
Quaternary structure:
Homodimer.
Three dimensional structures from OCA and Proteopedia for S100A16 Gene
- 2L50 (3D)
- 2L51 (3D)
- 3NXA (3D)

neXtProt entry for S100A16 Gene

Proteomics data for S100A16 Gene at MOPED

Protein Expression for S100A16 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for S100A16 Gene

Modification sites at PhosphoSitePlus
- Q96FQ6
Modification sites at neXtProt
- NX_Q96FQ6

Other Protein References for S100A16 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies

R&D Systems Antibodies for S100A16 (S100A16)

OriGene Antibodies for S100A16
- TA316124
Custom Antibody Services

Novus Biologicals Antibodies for S100A16

Search for Antibodies for S100A16 at Abcam

Cloud-Clone Corp. Antibodies for S100A16
- PAD157Hu71
- PAD157Hu01

Invitrogen Antibodies for S100A16

antibodies-online Antibodies for S100A16: See all 31

GeneTex S100A16 antibody for S100A16

Santa Cruz Biotechnology (SCBT) Antibodies for S100A16

Protein Products

Browse Purified and Recombinant Proteins at EMD Millipore

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Browse Enzo Life Sciences for proteins

OriGene Purified Proteins for S100A16
Search Origene for MassSpec and Protein Over-expression Lysates for S100A16
Origene Custom Protein Services for S100A16

GenScript Custom Purified and Recombinant Proteins Services for S100A16

Novus Biologicals proteins and lysates for S100A16

Sino Biological Recombinant Proteins for S100A16
Browse Sino Biological Cell Lysates

ProSpec Recombinant Proteins for S100A16

Cloud-Clone Corp. Proteins for S100A16
- RPD157Hu01

Search eBioscience for S100A16 related proteins

antibodies-online Proteins for S100A16: See all 18
Search antibodies-online for peptides

Search GeneTex for Proteins for S100A16

Search for Proteins for S100A16 at Abcam

Assay Products

Browse Kits and Assays available from EMD Millipore

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for S100A16

Browse Enzo Life Sciences for kits & assays

Cloud-Clone Corp Assay Kits for S100A16
- SED157Hu

Search eBioscience for S100A16 related elisas

antibodies-online Kits for S100A16: See all 5

Search for Assays for S100A16 at Abcam

No data available for DME Specific Peptides for S100A16 Gene

Domains & Families for S100A16 Gene

Gene Families for S100A16 Gene

HGNC:

Protein Domains for S100A16 Gene

InterPro:

Blocks:

Calcium-binding protein, S-100/ICaBP type

ProtoNet:

Q96FQ6

Suggested Antigen Peptide Sequences for S100A16 Gene

GenScript: Design optimal peptide antigens:

S100 calcium-binding protein A16 (S10AG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FQ6

UniProtKB/Swiss-Prot:

S10AG_HUMAN :

Contains 2 EF-hand domains.
Belongs to the S-100 family.

Domain:

Contains 2 EF-hand domains.

Family:

Belongs to the S-100 family.

Function for S100A16 Gene

Molecular function for S100A16 Gene

UniProtKB/Swiss-Prot Function:

Calcium-binding protein. Binds one calcium ion per monomer.

S10AG_HUMAN,Q96FQ6

Gene Ontology (GO) - Molecular Function for S100A16 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IDA	17030513
GO:0042803	protein homodimerization activity	IPI	17030513

Phenotypes for S100A16 Gene

GenomeRNAi human phenotypes for S100A16:

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

ViGene Biosciences lentiviral particle packaged cDNA for S100A16 gene
- LH843450
ViGene Biosciences ready-to-package AAV shRNAs for S100A16 gene
- SH843450
Search ViGene Biosciences for S100A16

CRISPR Products

OriGene CRISPR knockouts for S100A16
- KN315235
- KN203879

Santa Cruz Biotechnology (SCBT) CRISPR for S100A16

GenScript: Design CRISPR guide RNA sequences for S100A16

miRNA for S100A16 Gene

miRTarBase miRNAs that target S100A16

miRNA Products

Search ViGene Biosciences for S100A16

Inhibitory RNA Products

Origene rat_shrna, mouse_rna, shRNA, siRNA, and RNAi products in human, mouse, rat for S100A16
Browse OriGene Inhibitory RNA Products For S100A16

ViGene Biosciences ready-to-package AAV shRNAs for S100A16 gene
- SH843450

Search Santa Cruz Biotechnology (SCBT) for S100A16 siRNA/shRNA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A16 Gene

Localization for S100A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A16 Gene

Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. Translocates from the nucleolus to the cytoplasm in response to an increase of intracellular calcium levels.

Q96FQ6-S10AG_HUMAN

Subcellular locations from

COMPARTMENTS

Jensen Localization Image for S100A16 Gene

Compartment	Confidence
cytosol	5
extracellular	5
nucleus	5
plasma membrane	5
cytoskeleton	1

Gene Ontology (GO) - Cellular Components for S100A16 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	17030513
GO:0005737	cytoplasm	IDA	--
GO:0070062	extracellular exosome	IDA	19056867

Pathways & Interactions for S100A16 Gene

SuperPathways for S100A16 Gene

More details on SuperPathways for S100A16

No Data Available

Interacting Proteins for S100A16 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357692%0d%0a9606.ENSP00000340463%0d%0a9606.ENSP00000367923%0d%0a9606.ENSP00000377446%0d%0a9606.ENSP00000299518%0d%0a9606.ENSP00000196371%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: Q96FQ6-S10AG_HUMAN ENSP00000357692 for S100A16 Gene via MINT STRING UniProtKB I2D

Symbol	External ID(s)	Details
S100A14	Q9HCY8 ¹⁹ ⁴ ²¹ ENSP00000340463 ²⁰	MINT-68275 STRING: ENSP00000340463 EBI-751850, EBI-751842 I2D: score=4
GABARAPL1	ENSP00000266458 ²⁰ Q9H0R8 ²¹	STRING: ENSP00000266458 I2D: score=1
UCHL5	ENSP00000356425 ²⁰ Q9Y5K5 ²¹	STRING: ENSP00000356425 I2D: score=1
CPNE2	ENSP00000290776 ²⁰	STRING: ENSP00000290776
ERBB2	ENSP00000269571 ²⁰	STRING: ENSP00000269571

Gene Ontology (GO) - Biological Process for S100A16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for S100A16 Gene

Drugs & Compounds for S100A16 Gene

No Compound Related Data Available

Drug Products

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for S100A16

Browse compounds at ApexBio

Transcripts for S100A16 Gene

mRNA/cDNA for S100A16 Gene

(5) REFSEQ mRNAs :

(8) Additional mRNA sequences :

(573) Selected AceView cDNA sequences:

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A16 Gene

S100 calcium binding protein A16:

Hs.515714

Representative Sequences:

BQ920362

CRISPR Products

OriGene CRISPR knockouts for S100A16
- KN315235
- KN203879

Santa Cruz Biotechnology (SCBT) CRISPR for S100A16

GenScript: Design CRISPR guide RNA sequences for S100A16

miRNA Products

Search ViGene Biosciences for S100A16

Inhibitory RNA Products

Origene rat_shrna, mouse_rna, shRNA, siRNA, and RNAi products in human, mouse, rat for S100A16
Browse OriGene Inhibitory RNA Products For S100A16

ViGene Biosciences ready-to-package AAV shRNAs for S100A16 gene
- SH843450

Search Santa Cruz Biotechnology (SCBT) for S100A16 siRNA/shRNA

Clone Products

OriGene clones in human for S100A16
OriGene ORF clones in human,mouse,rat for S100A16
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA clones in your preferred vector

Sino Biological Human cDNA Clone for S100A16

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for S100A16

Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for S100A16 Gene

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g	^	8
SP1:											-						-
SP2:					-		-		-		-						-
SP3:					-		-		-		-
SP4:							-		-		-						-
SP5:											-						-
SP6:											-						-		-		-		-		-		-		-
SP7:																	-

Relevant External Links for S100A16 Gene

GeneLoc Exon Structure for: S100A16
ECgene alternative splicing isoforms for: S100A16

Expression for S100A16 Gene

mRNA expression in normal human tissues for S100A16 Gene

mRNA expression by BioGPS for S100A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Gut Tube (Gastrointestinal Tract)
- Hindgut
- Foregut
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
Endoderm (Gastrulation Derivatives)
- Definitive endoderm-like cells(Hinton A et. al. 2010)
Germ Cells (Reproductive System)
- Primordial germ cell-like cells(Hayashi K et. al. 2011)
Gonad
- Primordial germ cell-like cells(Hayashi K et. al. 2011)

mRNA differential expression in normal tissues according to GTEx for S100A16 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.5).

Protein differential expression in normal tissues from HIPED for S100A16 Gene

This gene is overexpressed in Nasal epithelium (13.2), Cervix (6.5), and Saliva (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A16 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for S100A16 Gene

SOURCE GeneReport for Unigene cluster for S100A16 Gene Hs.515714

Protein tissue co-expression partners for S100A16 Gene

GNG12

- Elite partner

Primer Products

OriGene qPCR primer pairs and template standards for S100A16
- HK206502
OriGene qPCR primer pairs for S100A16
- HP216668

No data available for mRNA Expression by UniProt/SwissProt for S100A16 Gene

Orthologs for S100A16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A16 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	S100A16 ³⁵	89.64 (n) 90.29 (a)		505679 NM_001075218.1 NP_001068686.1
cow (Bos Taurus)	Mammalia	S100A16 ³⁶	90 (a)	OneToOne	3:16830511-16837422
dog (Canis familiaris)	Mammalia	S100A16 ³⁵	90.61 (n) 90.29 (a)		490458 XM_861080.3 XP_866173.1
dog (Canis familiaris)	Mammalia	S100A16 ³⁶	90 (a)	OneToOne	7:43447070-43452839
mouse (Mus musculus)	Mammalia	S100a16 ³⁵	83.82 (n) 84.47 (a)		67860 NM_026416.2 NP_080692.1
		S100a16 ¹⁶			90537254
		S100a16 ³⁶	72 (a)	OneToOne	3:90537254-90543151
chimpanzee (Pan troglodytes)	Mammalia	S100A16 ³⁵	99.68 (n) 99.03 (a)		457322 XM_003308496.2 XP_003308544.1
chimpanzee (Pan troglodytes)	Mammalia	S100A16 ³⁶	99 (a)	OneToOne	1:131852382-131854024
rat (Rattus norvegicus)	Mammalia	S100a16 ³⁵	87.33 (n) 87 (a)		361991 NM_001108557.2 NP_001102027.1
oppossum (Monodelphis domestica)	Mammalia	S100A16 ³⁶	84 (a)	OneToOne	2:187918881-187919666
chicken (Gallus gallus)	Aves	S100A16 ³⁵	73.05 (n) 68.09 (a)		100859094 XM_003642637.2 XP_003642685.1
chicken (Gallus gallus)	Aves	S100A16 ³⁶	61 (a)	OneToOne	25:719869-722103
tropical clawed frog (Silurana tropicalis)	Amphibia	Str.3327 ³⁵			BQ527127.1

Species with no ortholog for S100A16:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
lizard (Anolis carolinensis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
platypus (Ornithorhynchus anatinus)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea squirt (Ciona intestinalis)
sea squirt (Ciona savignyi)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)
zebrafish (Danio rerio)

Evolution for S100A16 Gene

ENSEMBL:: Gene Tree for S100A16 (if available)
TreeFam:: Gene Tree for S100A16 (if available)

Paralogs for S100A16 Gene

(13) SIMAP similar genes for S100A16 Gene using alignment to 1 proteins:

S10AG_HUMAN

No data available for Paralogs for S100A16 Gene

Variants for S100A16 Gene

Sequence variations from dbSNP and Humsavar for S100A16 Gene

SNP ID	Clin	Chr 01 pos	Sequence Context	Type
rs9699949	--	153,611,510(+)	ACCTG(C/G)AATTC	intron-variant
rs9700179	--	153,613,108(+)	GGCTC(A/G)GTGGG	upstream-variant-2KB
rs9700928	--	153,612,510(+)	TGGAA(A/C)CTGCC	intron-variant
rs9792913	--	153,609,927(+)	CCCTT(A/G)TCTTC	intron-variant, upstream-variant-2KB
rs9793310	--	153,609,931(+)	TGTCT(C/T)CCCTC	intron-variant, upstream-variant-2KB

Variation tolerance for S100A16 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 0.43; 9.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for S100A16 Gene

Disorders for S100A16 Gene

Relevant External Links for S100A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:: S100A16

No disorders were found for S100A16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A16 Gene

Publications for S100A16 Gene

Structural characterization of human S100A16, a low-affinity calcium binder. (PMID: 21046186) Babini E. … Parigi G. (J. Biol. Inorg. Chem. 2011) ³ ⁴ ⁶⁷
Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy P.H. … Tagle D.A. (Genomics 1997) ² ³
Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion. (PMID: 25884418) Tanaka M. … Sugino T. (BMC Cancer 2015) ³
The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) ³
Up-regulation of S100A16 expression promotes epithelial-mesenchymal transition via Notch1 pathway in breast cancer. (PMID: 25287362) Zhou W. … Wang S. (J. Biomed. Sci. 2014) ³