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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

S100A16 Gene

protein-coding GIFtS: 50
GCID: GC01M153579

S100 Calcium Binding Protein A16

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
S100 Calcium Binding Protein A16¹ ²		S100 Calcium-Binding Protein A16² ³
Aging-Associated Gene 13 Protein² ³		DT1P1A7²
Protein S100-F² ³		Aging-Associated Protein 13²
S100F² ³		Protein S100-A16²

External Ids:	HGNC: 20441¹	Entrez Gene: 140576²	Ensembl: ENSG00000188643⁷	UniProtKB: Q96FQ6³

Export aliases for S100A16 gene to outside databases

Previous GC identifers: GC01M9A0123 GC01M9A0392 GC01M150393 GC01M151845 GC01M124942

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for S100A16 Gene:

S100A16 (S100 calcium binding protein A16) is a protein-coding gene. Diseases associated with S100A16 include hepatocellular carcinoma. GO annotations related to this gene include protein homodimerization activity and calcium ion binding.

UniProtKB/Swiss-Prot: S10AG_HUMAN, Q96FQ6

Function: Calcium-binding protein. Binds one calcium ion per monomer

Gene Wiki entry for S100A16 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004487.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the S100A16 gene promoter:
Brachyury MyoD FOXD1 MIF-1 STAT5A LCR-F1 AREB6 CREB deltaCREB Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100A16 promoter sequence

Search SABiosciences Chromatin IP Primers for S100A16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

S100A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A16 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M153579: view genomic region (about GC identifiers)

Start:	153,579,362 bp from pter	End:	153,585,621 bp from pter
Size:	6,260 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S10AG_HUMAN, Q96FQ6 (See protein sequence)

Recommended Name: Protein S100-A16

Size: 103 amino acids; 11801 Da

Subunit: Homodimer

Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. Translocates from the nucleolus to the

cytoplasm in response to an increase of intracellular calcium levels

3 PDB 3D structures from and Proteopedia for S100A16:

2L50 (3D)

2L51 (3D)

3NXA (3D)

Secondary accessions: A8K439 D3DV52 Q5RHS6

Explore the universe of human proteins at neXtProt for S100A16: NX_Q96FQ6

Explore proteomics data for S100A16 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96FQ6

S100A16 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_525127.1

ENSEMBL proteins:

ENSP00000357693 ENSP00000357695 ENSP00000357692 ENSP00000357694

Human Recombinant Protein Products for S100A16:

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005730	nucleolus	IDA	17030513
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	IDA	17030513
GO:0005886	plasma membrane	IDA	--

S100A16 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

EFHAND: EF-hand domain containing

S100: S100 calcium binding proteins

4 InterPro protein domains:

IPR018247 EF_Hand_1_Ca_BS

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_dom

IPR001751 S100/CaBP-9k_CS

Graphical View of Domain Structure for InterPro Entry Q96FQ6

ProtoNet protein and cluster: Q96FQ6

1 Blocks protein domain: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10AG_HUMAN, Q96FQ6

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

S100A16 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S10AG_HUMAN, Q96FQ6

Function: Calcium-binding protein. Binds one calcium ion per monomer

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IDA	17030513
GO:0042803	protein homodimerization activity	IPI	17030513

S100A16 for ontologies About GeneDecksing

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for S100A16

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for S100A16 (Q96FQ6^{2, 3} ENSP00000357692⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
S100A14	Q9HCY8²^,³, ENSP00000340463⁴	MINT-68275 I2D: score=4 STRING: ENSP00000340463
UCHL5	Q9Y5K5³, ENSP00000356425⁴	I2D: score=1 STRING: ENSP00000356425
GABARAPL1	Q9H0R8³	I2D: score=1
CERS2	ENSP00000271688⁴	STRING: ENSP00000271688
ECM1	ENSP00000358043⁴	STRING: ENSP00000358043

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051592	response to calcium ion	IEA	--

S100A16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for S100A16 (S10AG)

Search CenterWatch for drugs/clinical trials and news about S100A16 / S10AG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for S100A16 gene:

NM_080388.1

Unigene Cluster for S100A16:

S100 calcium binding protein A16

Hs.515714 [show with all ESTs]

Unigene Representative Sequence: BQ920362

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368704 ENST00000368706(uc001fcd.1) ENST00000368703 ENST00000368705(uc001fcc.2)

ENST00000474991

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		hsa-miR-4310
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Additional mRNA sequence:

AK290804.1 AY221961.1 AY762098.1 BC010541.1 BC019099.1 BC095462.1 U23859.1 U92985.1

12 DOTS entries:

DT.95288033 DT.448132 DT.100788970 DT.91772678 DT.91772670 DT.95176495 DT.95176522 DT.100788973

DT.121450699 DT.75131082 DT.91941117 DT.95212076

24/573 AceView cDNA sequences (see all 573):

BQ653175 BM984930 BQ939988 BM999349 BM915870 CA440985 CA421176 BQ224401

BI254846 BQ232812 CN483324 BU542079 BM989016 BE906900 BM975399 BQ901197

AV646282 BG680976 AW026670 BG284784 AA502335 BI259492 AI306701 AA303323

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for S100A16 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g	^	8
SP1:											-						-
SP2:					-		-		-		-						-
SP3:					-		-		-		-
SP4:							-		-		-						-
SP5:											-						-

ECgene alternative splicing isoforms for S100A16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

S100A16 expression in normal human tissues (normalized intensities) S100A16 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCAGGAGCA

About this image

S100A16 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/8 selected tissues (see all 8) fully expand


Gut Tube (Gastrointestinal Tract) fully expand to see all 2 entries
Hindgut

Lower Urinary Tract (Urinary System) fully expand to see all 2 entries
visceral organ/urethra of male

Epidermis (Integumentary System)
skin/epidermis

Ovary (Reproductive System)
Ovarian Somatic Cells Ovigerous Cord

Nose (Sensory Organs)
sensory organ/nose/naris

See S100A16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100A16

SOURCE GeneReport for Unigene cluster: Hs.515714

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for S100A16 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	S100a16^{1 , 5}	S100 calcium binding protein A16^{1, 5}	83.82(n)¹ 84.47(a)¹	3 (39.25 cM)⁵ 67860¹ NM_026416.2¹ NP_080692.1¹ 90537254⁵
chicken (Gallus gallus)	Aves	LOC100859094¹	protein S100-A16-like	73.05(n) 68.09(a)	100859094 XM_003642637.1 XP_003642685.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.3327²	Transcribed sequence with weak similarity to protein more	75.15(n)	BQ527127.1

ENSEMBL Gene Tree for S100A16 (if available)
TreeFam Gene Tree for S100A16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for S100A16 gene

13 SIMAP similar genes for S100A16 using alignment to 1 protein entry: S10AG_HUMAN:

S100B S100Z S100A4 S100P S100A13 S100A10

S100A6 HRNR S100A12 S100A2 S100A11 S100A14

S100A8

S100A16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116449005^1,2	C,F	--	153578987(+)	`CTGTAC/GAGGGG`	1	--	int¹		1		WA	118
rs55767731^1,2	C	--	153579068(+)	`AAAAA-/A/AA GACTA`	1	--	int¹		1		NA	2
rs28548477^1,2	C	--	153579086(+)	`TGGTCC/GCTCTC`	1	--	int¹		2		NA	4
rs180880030^1,2		--	153579109(+)	`AGTGAA/GGACTA`	1	--	int¹		0	--	--	--	--
rs138505639^1,2		--	153579459(+)	`CAACAA/GGAGGA`	1	--	ut3¹		0	--	--	--	--
rs141728041^1,2	C	--	153579817(+)	`TGAGA-/CCCCCC`	1	--	ut3¹		0	--	--	--	--
rs115917975^1,2	C,F	--	153579864(+)	`AGGGAC/ACCCAG`	1	--	ut3¹		1		WA	118
rs201595733^1,2		--	153580051(+)	`TTTGGC/GGATGG`	2	P A	mis¹		0	--	--	--	--
rs147357546^1,2	C,F	--	153580052(+)	`TTGGCG/AATGGG`	2	/I	syn¹		2		NA EU	5875
rs201004264^1,2		--	153580060(+)	`GGGGCC/TGGTGA`	2	S G	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for S100A16 (153579362 - 153585621 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for S100A16: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100A16

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

S100A16 for disorders About GeneDecksing

2 diseases for S100A16: About MalaCards

hepatocellular carcinoma

Export disorders for S100A16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for S100A16 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with S100A16)

Utopia: connect your pdf to the dynamic
world of online information

Structural characterization of human S100A16, a low-affinity calcium binder. (PubMed id 21046186)^{1, 2} Babini E....Parigi G. (2011)
S100A16, a novel calcium-binding protein of the EF-ha nd superfamily. (PubMed id 17030513)^{1, 2} Sturchler E....Heizmann C.W. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)^{1, 3} Reddy P.H....Tagle D.A. (1997)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)¹ Fang Y....Shen X. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 140576	HGNC: 20441	AceView: S100A16	Ensembl:ENSG00000188643	euGenes: HUgn140576
ECgene: S100A16	H-InvDB: S100A16

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for S100A16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for S100A16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for S100A16 gene:
Search GeneIP for patents involving S100A16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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S100A16 Gene

S100 Calcium Binding Protein A16

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S100A16 Gene

S100 Calcium Binding Protein A16

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