Free for academic non-profit institutions. Other users need a Commercial license

Aliases for S100A16 Gene

Aliases for S100A16 Gene

  • S100 Calcium Binding Protein A16 2 3 5
  • Aging-Associated Gene 13 Protein 3 4
  • Protein S100-F 3 4
  • S100F 3 4
  • S100 Calcium-Binding Protein A16 4
  • Aging-Associated Protein 13 3
  • Protein S100-A16 3
  • DT1P1A7 3
  • AAG13 3

External Ids for S100A16 Gene

Previous GeneCards Identifiers for S100A16 Gene

  • GC01M9A0123
  • GC01M9A0392
  • GC01M150393
  • GC01M151845
  • GC01M124942

Summaries for S100A16 Gene

GeneCards Summary for S100A16 Gene

S100A16 (S100 Calcium Binding Protein A16) is a Protein Coding gene. Diseases associated with S100A16 include Robinow Syndrome. GO annotations related to this gene include poly(A) RNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot for S100A16 Gene

  • Calcium-binding protein. Binds one calcium ion per monomer.

Gene Wiki entry for S100A16 Gene

Additional gene information for S100A16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A16 Gene

Genomics for S100A16 Gene

Regulatory Elements for S100A16 Gene

Enhancers for S100A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H153561 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +47.6 47584 8.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1 CHTOP
GH01H153539 1.3 ENCODE dbSUPER 10.8 +67.6 67614 12 PKNOX1 ATF1 ARID4B SIN3A DMAP1 TCF12 GLIS2 CBX5 FOS ATF7 S100A3 S100A16 S100A14 S100A1 S100A13 CHTOP INTS3 ENSG00000233222 ENSG00000243613 ILF2
GH01H153552 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +59.3 59277 1.8 ZFHX2 NR3C1 EGR2 S100A3 CHTOP S100A13 S100A16 S100A14 S100A1 INTS3 ENSG00000233222 ENSG00000243613 ILF2
GH01H153596 1.4 Ensembl ENCODE dbSUPER 10 +14.9 14890 3.5 NFIB ZSCAN4 SIN3A BATF RFX5 ETS1 GTF3C2 ATF7 ETV6 FOS ILF2 UBAP2L CREB3L4 CHTOP CRTC2 S100A13 ENSG00000272030 S100A16 SLC27A3 GC01P153610
GH01H153606 2 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +0.7 686 11.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 S100A1 SNAPIN ILF2 CRTC2 ENSG00000233222 ENSG00000243613 INTS3 S100A16 S100A13 ENSG00000272030
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S100A16 on UCSC Golden Path with GeneCards custom track

Promoters for S100A16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013812 645 1401 TBP SOX13 TFAP4 KLF1 ZNF792 ARID4B KLF17 MAX ZIC2 RAD21

Genomic Locations for S100A16 Gene

Genomic Locations for S100A16 Gene
6,260 bases
Minus strand

Genomic View for S100A16 Gene

Genes around S100A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A16 Gene

Proteins for S100A16 Gene

  • Protein details for S100A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A16
    Protein Accession:
    Secondary Accessions:
    • A8K439
    • D3DV52
    • Q5RHS6

    Protein attributes for S100A16 Gene

    103 amino acids
    Molecular mass:
    11801 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for S100A16 Gene

neXtProt entry for S100A16 Gene

Post-translational modifications for S100A16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A16 Gene

Antibody Products

  • Abcam antibodies for S100A16
  • Santa Cruz Biotechnology (SCBT) Antibodies for S100A16

No data available for DME Specific Peptides for S100A16 Gene

Domains & Families for S100A16 Gene

Gene Families for S100A16 Gene

Suggested Antigen Peptide Sequences for S100A16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A16: view

Function for S100A16 Gene

Molecular function for S100A16 Gene

UniProtKB/Swiss-Prot Function:
Calcium-binding protein. Binds one calcium ion per monomer.

Phenotypes From GWAS Catalog for S100A16 Gene

Gene Ontology (GO) - Molecular Function for S100A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005509 calcium ion binding IDA 17030513
GO:0005515 protein binding IPI 16189514
GO:0042803 protein homodimerization activity IPI 17030513
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A16: view
genes like me logo Genes that share phenotypes with S100A16: view

Animal Model Products

miRNA for S100A16 Gene

miRTarBase miRNAs that target S100A16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A16 Gene

Localization for S100A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A16 Gene

Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. Translocates from the nucleolus to the cytoplasm in response to an increase of intracellular calcium levels.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A16 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 21805676
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA 17030513
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 17030513
genes like me logo Genes that share ontologies with S100A16: view

Pathways & Interactions for S100A16 Gene

SuperPathways for S100A16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051592 response to calcium ion IEA --
genes like me logo Genes that share ontologies with S100A16: view

No data available for Pathways by source and SIGNOR curated interactions for S100A16 Gene

Drugs & Compounds for S100A16 Gene

(2) Drugs for S100A16 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
genes like me logo Genes that share compounds with S100A16: view

Transcripts for S100A16 Gene

Unigene Clusters for S100A16 Gene

S100 calcium binding protein A16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - -
SP7: -

Relevant External Links for S100A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A16 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.5).

Protein differential expression in normal tissues from HIPED for S100A16 Gene

This gene is overexpressed in Nasal epithelium (13.2), Cervix (6.5), and Saliva (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100A16 Gene

Protein tissue co-expression partners for S100A16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A16 Gene:


SOURCE GeneReport for Unigene cluster for S100A16 Gene:


Evidence on tissue expression from TISSUES for S100A16 Gene

  • Skin(4.8)
  • Nervous system(4.6)
  • Kidney(4.4)
  • Lung(3.3)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with S100A16: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A16 Gene

Orthologs for S100A16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A16 34 33
  • 99.68 (n)
(Canis familiaris)
Mammalia S100A16 34 33
  • 90.61 (n)
(Bos Taurus)
Mammalia S100A16 34 33
  • 89.64 (n)
(Rattus norvegicus)
Mammalia S100a16 33
  • 87.33 (n)
(Monodelphis domestica)
Mammalia S100A16 34
  • 84 (a)
(Mus musculus)
Mammalia S100a16 34 16 33
  • 83.82 (n)
(Gallus gallus)
Aves S100A16 34 33
  • 73.05 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3327 33
Species where no ortholog for S100A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A16 Gene

Gene Tree for S100A16 (if available)
Gene Tree for S100A16 (if available)

Paralogs for S100A16 Gene

(13) SIMAP similar genes for S100A16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A16: view

No data available for Paralogs for S100A16 Gene

Variants for S100A16 Gene

Sequence variations from dbSNP and Humsavar for S100A16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000210330 -- 153,609,290(+) CACCA(C/G)AGCCT intron-variant, utr-variant-5-prime
rs1000417429 -- 153,611,234(+) CCCAC(A/C)CTCCC intron-variant, upstream-variant-2KB
rs1000536647 -- 153,610,208(+) AAACC(A/G/T)TGCCC intron-variant, upstream-variant-2KB
rs1000585430 -- 153,609,084(+) GAGTC(A/G)CGGCC intron-variant, utr-variant-5-prime
rs1000679863 -- 153,610,270(+) GAAGA(C/T)AATTC intron-variant, upstream-variant-2KB

Variation tolerance for S100A16 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A16 Gene

Disorders for S100A16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100A16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
robinow syndrome
  • acral dysostosis with facial and genital abnormalities
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with S100A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A16 Gene

Publications for S100A16 Gene

  1. Structural characterization of human S100A16, a low-affinity calcium binder. (PMID: 21046186) Babini E … Parigi G (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011) 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. S100A16, a novel calcium-binding protein of the EF-hand superfamily. (PMID: 17030513) Sturchler E … Heizmann CW (The Journal of biological chemistry 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy PH … Tagle DA (Genomics 1997) 2 3 60

Products for S100A16 Gene

Sources for S100A16 Gene

Loading form....