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S100A16 Gene

protein-coding GIFtS: 51

GC01M151845

S100 calcium binding protein A16
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AAG13 ^²
DT1P1A7 ^¹, ²
MGC17528 ^¹, ²
OTTHUMP00000015465 ^²
OTTHUMP00000015466 ^²
OTTHUMP00000032893 ^²
OTTHUMP00000032894 ^²
S100F ^¹, ²

Descriptions
Aging-associated gene 13 protein ^³
Protein S100F ^³
S100 calcium binding protein A16 ^²
S100 calcium-binding protein A16 ^³
aging-associated protein 13 ^²

External Ids
HGNC: 20441¹
Entrez Gene: 140576²
UniProtKB: Q96FQ6³
Ensembl: ENSG00000188643⁷

Search outside databases for aliases for S100A16 gene

Previous GC identifers: GC01M9A0123 GC01M9A0392 GC01M150393

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for S100A16

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the S100A16 gene

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

S100A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M151845: (about GC identifiers)

Start:	151,845,986 bp from pter
End:	151,852,183 bp from pter
Size:	6,198 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S10AG_HUMAN, Q96FQ6 (See protein sequence)

Recommended Name: Protein S100-A16

Size: 103 amino acids; 11801 Da

Secondary accessions: Q5RHS6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_525127.1

ENSEMBL proteins:

ENSP00000357695 ENSP00000357694 ENSP00000357693 ENSP00000357692

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S100A16)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for S100A16:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for S100A16
	Antibodies from Abcam (S100A16), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S100A16)
	Search Novus for antibodies for S100A16

Assays for S100A16:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96FQ6

ProtoNet protein and cluster: Q96FQ6

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10AG_HUMAN, Q96FQ6

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A16)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A16)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080388

Applied Biosystems Silencer® siRNAs for S100A16

Sigma-Aldrich siRNA and siRNA Panels for S100A16

Sigma-Aldrich shRNA for S100A16

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100A16
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_080388
Myc/DDK tagged cDNA clone in CMV expression vector: NM_080388
untagged cDNA clone in CMV expression vector: NM_080388

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_080388

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for S100A16 (Q96FQ6²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
S100A14 Q9HCY8² MINT-68275
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A16

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A16)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A16)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080388

Sigma-Aldrich siRNA and siRNA Panels for S100A16

Sigma-Aldrich shRNA for S100A16

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_080388

REFSEQ mRNAs for S100A16 gene:

NM_080388.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_080388

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080388
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_080388
                                 untagged cDNA clone in CMV expression vector: NM_080388

Additional cDNA sequence:

AK290804.1 AY221961.1 AY762098.1 BC010541.1 BC019099.1 BC095462.1 U23859.1 U92985.1

12 DOTS entries:

DT.95288033 DT.448132 DT.100788970 DT.91772678 DT.91772670 DT.95176495 DT.95176522 DT.100788973

DT.121450699 DT.75131082 DT.91941117 DT.95212076

24/573 AceView cDNA sequences (see all 573 ):

BG749261 AA303323 AI306701 BU188679 BM989016 BQ653175 AA502335 BG680976

BM707853 BM970435 BM560438 BF034566 AA659027 U23859 BQ082667 BQ226241

CF126591 BM831265 CA440091 BM757074 BU193767 AI334966 BQ688938 BM562238

highest scoring ESTs for S100A16:

AA053648 AA133008 AA314092 AA315476 AA315987 AA329443 AA335138 AA386092 AA411572 AA427682

Unigene Cluster for S100A16:

S100 calcium binding protein A16

Hs.515714 [show with all ESTs]

Unigene Representative Sequence: BQ920362

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for S100A16 (see all 7 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g	^	8
SP1:											-						-
SP2:					-		-		-		-						-
SP3:					-		-		-		-
SP4:							-		-		-						-
SP5:											-						-

About this scheme

ECgene alternative splicing isoforms for S100A16

4 Ensembl transcripts including schematic representations:

ENST00000368706 ENST00000368705 ENST00000368704 ENST00000368703

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A16 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100A16

¹ / ² / ³

3 probe-sets matching S100A16 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65818_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AA149276	0.40	1.00	0.76	1
227998_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA045184	0.60	1.00	0.82	1
227998_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCAGGAGCA

SOURCE GeneReport for Unigene cluster: Hs.515714

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100A16 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC490458¹	--	similar to S100 calcium binding protein A16	90.61(n) 90.29(a)	490458 XM_547580.2 XP_547580.1
chimpanzee (Pan troglodytes)	S100A16¹	--	S100 calcium binding protein A16	99.68(n) 99.03(a)	457322 XM_513817.2 XP_513817.2
cow (Bos taurus)	S100A16¹	--	S100 calcium binding protein A16	89.64(n) 90.29(a)	505679 NM_001075218.1 NP_001068686.1
rat (Rattus norvegicus)	S100a16¹	--	S100 calcium binding protein A16	87.33(n) 87(a)	361991 XM_342291.3 XP_342292.1
mouse (Mus musculus)	S100a16^{1, 5}	3⁵	S100 calcium binding protein A16^{1, 5}	83.82(n)¹ 84.47(a)¹	67860¹ NM_026416.2¹ NP_080692.1¹ AI325039⁵ AI663996⁵ (see all 14)

About this table Species with no ortholog for S100A16

ENSEMBL Gene Tree for S100A16

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/43 NCBI SNPs in S100A16 are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 15)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs28548477^1,2	C	151845710(+)	`TGGTCC/GCTCTC`	1	--	ng5¹		0	--	--	--	--
	rs9700179^1,2	C	151852208(+)	`GGCTCA/GGTGGG`	1	--	ng3¹		0	--	--	--	--
	rs9660679^1,2	C,F	151848882(+)	`CGTCCC/TTGACC`	1	--	int¹		4		NA EA	362
	rs11497739^1,2	C,F	151849690(+)	`AGAGCA/GGGAGC`	1	--	int¹		2		NA	182
	rs9700928^1,2	C	151851610(+)	`TGGAAA/CCTGCC`	1	--	int¹		0	--	--	--	--
	rs9792913^1,2	C	151849027(+)	`CCCTTA/GTCTCC`	1	--	int¹		0	--	--	--	--
--	rs9793310^1,2	C	151849031(+)	`TATCTC/TCCCTC`	1	--	int¹ trp³		0	--	--	--	--
--	rs9699949^1,2	C	151850610(+)	`ACCTGC/GAATTC`	1	--	int¹		0	--	--	--	--
	rs28414668^1,2	--	151846095(+)	`GCTCAC/GCCTTG`	1	--	ut3¹		0	--	--	--	--
--	rs66702524^1,2	--	151845691(+)	`AAAAA-/AAGACTA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for S100A16 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for S100A16 gene:

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)^{2, 3} Reddy P.H....Tagle D.A. (1997)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Nucleolar proteome dynamics. (PubMed id 15635413)³ Andersen J.S....Mann M. (2005)
S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors. (PubMed id 14684152)³ Marenholz I. and Heizmann C.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 140576	HGNC: 20441	AceView: S100A16	Ensembl:ENSG00000188643	euGenes: HUgn140576
ECgene: S100A16	H-InvDB: S100A16

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for S100A16
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for S100A16:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100A16-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100A16		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for S100A16		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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S100A16 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for S100A16

Summaries
for S100A16

Genomic Location
for S100A16

Proteins
for S100A16

Protein Domains/
Families
for S100A16

Gene Function
for S100A16

Pathways & Interactions
for S100A16

Drugs & Compounds
for S100A16

Transcripts
for S100A16

Expression
for S100A16

Orthologs
for S100A16

Paralogs
for S100A16

SNPs/Variants
for S100A16

Disorders & Mutations
for S100A16

Medical News
for S100A16

Publications
for S100A16

Search for S100A16

Genome Databases showing S100A16

Other Databases showing S100A16

Specialized Databases showing S100A16

Licensable Technologies
for S100A16

Services
for S100A16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100A16 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor S100A16

Summariesfor S100A16

Genomic Locationfor S100A16

Proteinsfor S100A16

Protein Domains/Familiesfor S100A16

Gene Functionfor S100A16

Pathways & Interactionsfor S100A16

Drugs & Compoundsfor S100A16

Transcriptsfor S100A16

Expression for S100A16

Orthologsfor S100A16

Paralogsfor S100A16

SNPs/Variantsfor S100A16

Disorders & Mutationsfor S100A16

Medical Newsfor S100A16

Publicationsfor S100A16

Search for S100A16

Genome Databases showing S100A16

Other Databases showing S100A16

Specialized Databases showing S100A16

Licensable Technologiesfor S100A16

Servicesfor S100A16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100A16

Summaries
for S100A16

Genomic Location
for S100A16

Proteins
for S100A16

Protein Domains/
Families
for S100A16

Gene Function
for S100A16

Pathways & Interactions
for S100A16

Drugs & Compounds
for S100A16

Transcripts
for S100A16

Expression
for S100A16

Orthologs
for S100A16

Paralogs
for S100A16

SNPs/Variants
for S100A16

Disorders & Mutations
for S100A16

Medical News
for S100A16

Publications
for S100A16

Licensable Technologies
for S100A16

Services
for S100A16