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S100A14 Gene

protein-coding GIFtS: 54

GC01M151853

S100 calcium binding protein A14
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCMP84 ^¹, ², ⁵
OTTHUMP00000032964 ^²
OTTHUMP00000032965 ^²
OTTHUMP00000032966 ^²
S100A15 ^¹, ², ³
S114 ^³

Descriptions
S100 calcium binding protein A14 ^²
S100 calcium-binding protein A14 ^³
breast cancer membrane protein 84 ^²

External Ids
HGNC: 18901¹
Entrez Gene: 57402²
UniProtKB: Q9HCY8³
Ensembl: ENSG00000189334⁷

Search outside databases for aliases for S100A14 gene

Previous GC identifers: GC07P101386 GC01U900004 GC01M9A0130 GC01M9A0399 GC01M150399

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A14:

S100A14 is a member of a subfamily of proteins related by Ca(2+)-binding motifs to the EF-hand

Ca(2+)-binding protein superfamily.[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the S100A14 gene

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.1

S100A14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M151853: (about GC identifiers)

Start:	151,853,355 bp from pter
End:	151,856,086 bp from pter
Size:	2,732 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S10AE_HUMAN, Q9HCY8 (See protein sequence)

Recommended Name: Protein S100-A14

Size: 104 amino acids; 11662 Da

Subcellular location: Cytoplasm

Secondary accessions: Q5RHT0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_065723.1

ENSEMBL proteins:

ENSP00000340463 ENSP00000357689 ENSP00000357690 ENSP00000357691

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S100 calcium binding protein A14)
	Human Recombinant Proteins from Abnova (S100A14)

OriGene Purified Recombinant Human Protein: S100A14

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for S100A14:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (S100 calcium binding protein A14), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S100A14)
	Novus Biologicals Antibody for S100A14

Assays for S100A14:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9HCY8

ProtoNet protein and cluster: Q9HCY8

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10AE_HUMAN, Q9HCY8

Similarity: Belongs to the S-100 family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A14)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A14)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020672

Applied Biosystems Silencer® siRNAs for S100A14

Sigma-Aldrich siRNA for S100A14

Sigma-Aldrich shRNA for S100A14

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S100A14
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020672
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020672
untagged cDNA clone in CMV expression vector: NM_020672

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020672

1 MGI phenotypic allele

for S100a14 (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Interacting proteins for S100A14 (ENSP00000357689³ Q9HCY8²) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
S100A16	Q96FQ6²	MINT-68275
S100A8	ENSP00000357722³	STRING (score=.791)
S100A2	ENSP00000357697³	STRING (score=.75)
S100A3	ENSP00000357701³	STRING (score=.741)
S100A11	ENSP00000271638³	STRING (score=.727)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A14

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S100A14)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S100A14)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020672

Sigma-Aldrich siRNA for S100A14

Sigma-Aldrich shRNA for S100A14

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020672

REFSEQ mRNAs for S100A14 gene:

NM_020672.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020672

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020672
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020672
                                 untagged cDNA clone in CMV expression vector: NM_020672

Additional cDNA sequence:

AY007220.1 BC005019.1

5 DOTS entries:

DT.107461 DT.100813530 DT.86840819 DT.92429565 DT.92429566

24/143 AceView cDNA sequences (see all 143 ):

AI270315 BM766050 AA583999 BM745637 BM765236 AI825924 CB142232 AW264641

AI950763 NM_020672 BU684216 AI926478 BM772161 BI335719 AI814942 BM765771

AI564980 AI569160 AY007220 CA432850 BM824988 BX415778 BM823443 BG680586

highest scoring ESTs for S100A14:

AI963434 AY007220 BG674026 BG677973 BG680586 BG696219 BG740697 BG742027 BG742907 BI091855

Unigene Cluster for S100A14:

S100 calcium binding protein A14

Hs.288998 [show with all ESTs]

Unigene Representative Sequence: BG674026

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for S100A14

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d
SP1:			-				-		-
SP2:							-		-
SP3:
SP4:													-

About this scheme

ECgene alternative splicing isoforms for S100A14

4 Ensembl transcripts including schematic representations:

ENST00000344616 ENST00000368700 ENST00000368701 ENST00000368702

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A14 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S100A14

¹ / ² / ³

3 probe-sets matching S100A14 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89770_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI963434	0.80	1.00	0.91	1
218677_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020672	0.60	1.00	0.82	1
218677_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGGGAGAGG

SOURCE GeneReport for Unigene cluster: Hs.288998
UniProtKB/Swiss-Prot: S10AE_HUMAN, Q9HCY8
Tissue specificity: Expressed at highest levels in colon and at moderate levels in thymus, kidney,
liver, small intestine, and lung. Low expression in heart and no expression is seen in brain,
skeletal muscle, spleen, placenta and peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S100A14 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC612322¹	--	similar to S100 calcium binding protein A14	87.91(n) 88.24(a)	612322 XM_850064.1 XP_855157.1
chimpanzee (Pan troglodytes)	S100A14¹	--	S100 calcium binding protein A14	99.68(n) 100(a)	457323 XM_001139808.1 XP_001139808.1
cow (Bos taurus)	S100A14¹	--	S100 calcium binding protein A14	91.91(n) 94.17(a)	618250 XM_001253822.1 XP_001253823.1
mouse (Mus musculus)	S100a14^{1, 5}	3⁵	S100 calcium binding protein A14^{1, 5}	87.46(n)¹ 92.08(a)¹	66166¹ NM_025393.2¹ NP_079669.1¹ AA612146⁵ AK003669⁵ (see all 8)

About this table Species with no ortholog for S100A14

ENSEMBL Gene Tree for S100A14

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S100A14 gene

S100A13²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in S100A14 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 13)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11548103^1,2	C	151854964(-)	`CAGTGA/GGCACC`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs4072425^1,2	C	151855467(+)	`GAAGGA/GAGGGG`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs9330298^1,2	C	151856878(+)	`TGCTCA/CCTCTG`	1	--	ng3¹		0	--	--	--	--
--	rs9792967^1,2	C	151854903(+)	`GAGCAA/GAAAGG`	1	--	int¹		0	--	--	--	--
--	rs9792963^1,2	C	151854832(+)	`GGCAAA/GGCCAA`	1	--	int¹		0	--	--	--	--
--	rs4073663^1,2	--	151857194(-)	`agttaA/Gttctc`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs57679975^1,2	--	151855483(+)	`GGGGGC/TTGGGC`	1	--	ng3¹		0	--	--	--	--
--	rs72711029^1,2	--	151856934(+)	`GCAAGC/TTCTGC`	1	--	ng3¹		0	--	--	--	--
--	rs71966979^1,2	--	151855840(+)	`TCTCT-/TCTC CTCTC`	1	--	ng3¹		0	--	--	--	--
--	rs67785169^1,2	--	151855830(+)	`TCTGT-/TCTC CTCTC`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for S100A14 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607986

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for S100A14 gene:

Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family. (PubMed id 11944983)^{2, 3, 4} Pietas A....Petersen I. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PubMed id 12477722)³ Adam P.J....Terrett J.A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Expression of S100 protein family members in the pathogenesis of bladder tumors. (PubMed id 17970044)¹ Yao R....Cheng L. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57402	HGNC: 18901	AceView: S100A14	Ensembl:ENSG00000189334	euGenes: HUgn57402
ECgene: S100A14	H-InvDB: S100A14

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for S100A14
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S100A14:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S100A14-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S100A14		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S100A14		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (S100A14)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (S100 calcium binding protein A14)

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	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for S100A14

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S100A14 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for S100A14

Summaries
for S100A14

Genomic Location
for S100A14

Proteins
for S100A14

Protein Domains/
Families
for S100A14

Gene Function
for S100A14

Pathways & Interactions
for S100A14

Drugs & Compounds
for S100A14

Transcripts
for S100A14

Expression
for S100A14

Orthologs
for S100A14

Paralogs
for S100A14

SNPs/Variants
for S100A14

Disorders & Mutations
for S100A14

Medical News
for S100A14

Publications
for S100A14

Search for S100A14

Genome Databases showing S100A14

Other Databases showing S100A14

Specialized Databases showing S100A14

Licensable Technologies
for S100A14

Services
for S100A14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S100A14 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor S100A14

Summariesfor S100A14

Genomic Locationfor S100A14

Proteinsfor S100A14

Protein Domains/Familiesfor S100A14

Gene Functionfor S100A14

Pathways & Interactionsfor S100A14

Drugs & Compoundsfor S100A14

Transcriptsfor S100A14

Expression for S100A14

Orthologsfor S100A14

Paralogsfor S100A14

SNPs/Variantsfor S100A14

Disorders & Mutationsfor S100A14

Medical Newsfor S100A14

Publicationsfor S100A14

Search for S100A14

Genome Databases showing S100A14

Other Databases showing S100A14

Specialized Databases showing S100A14

Licensable Technologiesfor S100A14

Servicesfor S100A14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S100A14

Summaries
for S100A14

Genomic Location
for S100A14

Proteins
for S100A14

Protein Domains/
Families
for S100A14

Gene Function
for S100A14

Pathways & Interactions
for S100A14

Drugs & Compounds
for S100A14

Transcripts
for S100A14

Expression
for S100A14

Orthologs
for S100A14

Paralogs
for S100A14

SNPs/Variants
for S100A14

Disorders & Mutations
for S100A14

Medical News
for S100A14

Publications
for S100A14

Licensable Technologies
for S100A14

Services
for S100A14