Aliases for S100A14 Gene
External Ids for S100A14 Gene
Previous GeneCards Identifiers for S100A14 Gene
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
GeneCards Summary for S100A14 Gene
S100A14 (S100 Calcium Binding Protein A14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and chemokine receptor binding. An important paralog of this gene is S100A13.
UniProtKB/Swiss-Prot for S100A14 Gene
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.