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Aliases for S100A14 Gene

Aliases for S100A14 Gene

  • S100 Calcium Binding Protein A14 2 3 5
  • S100A15 3 4
  • S114 3 4
  • Breast Cancer Membrane Protein 84 3
  • S100 Calcium-Binding Protein A14 4
  • Protein S100-A14 3
  • BCMP84 3

External Ids for S100A14 Gene

Previous GeneCards Identifiers for S100A14 Gene

  • GC07P101386
  • GC01U900004
  • GC01M9A0130
  • GC01M9A0399
  • GC01M150399
  • GC01M151853
  • GC01M153586
  • GC01M124950

Summaries for S100A14 Gene

Entrez Gene Summary for S100A14 Gene

  • This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

GeneCards Summary for S100A14 Gene

S100A14 (S100 Calcium Binding Protein A14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and chemokine receptor binding. An important paralog of this gene is S100A13.

UniProtKB/Swiss-Prot for S100A14 Gene

  • Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

Additional gene information for S100A14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A14 Gene

Genomics for S100A14 Gene

GeneHancer (GH) Regulatory Elements for S100A14 Gene

Promoters and enhancers for S100A14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I153606 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.1 +4.5 4527 11.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B S100A16 S100A14 S100A1 SNAPIN ILF2 ENSG00000233222 ENSG00000243613 INTS3 S100A13 ENSG00000272030
GH01I153561 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 +51.4 51425 8.8 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ZNF213 S100A2 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1
GH01I153539 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +71.5 71455 12 PKNOX1 ARID4B SIN3A DMAP1 CBX5 FOS DEK SP3 SP5 NFYC S100A3 LOC101928034 S100A4 S100A5 S100A16 S100A14 S100A1 CHTOP S100A13 INTS3
GH01I153355 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.2 +257.9 257855 7.4 RB1 RAD21 YY1 ARID2 ZNF143 CREM DEK ZNF654 SMARCC1 RXRA S100A9 ENSG00000224784 S100A8 RNU6-160P S100A14 S100A16 S100A12 PGLYRP4 LOC101928009
GH01I153552 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +63.1 63118 1.8 ZFHX2 EGR2 S100A3 CHTOP S100A13 S100A16 S100A14 S100A1 INTS3 ENSG00000233222 ENSG00000243613 ILF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around S100A14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A14 gene promoter:

Genomic Locations for S100A14 Gene

Genomic Locations for S100A14 Gene
chr1:153,614,255-153,616,986
(GRCh38/hg38)
Size:
2,732 bases
Orientation:
Minus strand
chr1:153,586,731-153,589,462
(GRCh37/hg19)

Genomic View for S100A14 Gene

Genes around S100A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A14 Gene

Proteins for S100A14 Gene

  • Protein details for S100A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCY8-S10AE_HUMAN
    Recommended name:
    Protein S100-A14
    Protein Accession:
    Q9HCY8
    Secondary Accessions:
    • Q5RHT0

    Protein attributes for S100A14 Gene

    Size:
    104 amino acids
    Molecular mass:
    11662 Da
    Quaternary structure:
    • Homodimer. Interacts with AGER.

    Three dimensional structures from OCA and Proteopedia for S100A14 Gene

neXtProt entry for S100A14 Gene

Post-translational modifications for S100A14 Gene

No Post-translational modifications

Other Protein References for S100A14 Gene

No data available for DME Specific Peptides for S100A14 Gene

Domains & Families for S100A14 Gene

Gene Families for S100A14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for S100A14 Gene

Suggested Antigen Peptide Sequences for S100A14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCY8

UniProtKB/Swiss-Prot:

S10AE_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A14: view

Function for S100A14 Gene

Molecular function for S100A14 Gene

UniProtKB/Swiss-Prot Function:
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

Gene Ontology (GO) - Molecular Function for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 16682778
GO:0005515 protein binding IPI 16189514
GO:0042379 chemokine receptor binding IMP 18606705
genes like me logo Genes that share ontologies with S100A14: view
genes like me logo Genes that share phenotypes with S100A14: view

Animal Models for S100A14 Gene

MGI Knock Outs for S100A14:

Animal Model Products

miRNA for S100A14 Gene

miRTarBase miRNAs that target S100A14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A14 Gene

Localization for S100A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A14 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Cell Junctions (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016604 nuclear body IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with S100A14: view

Pathways & Interactions for S100A14 Gene

SuperPathways for S100A14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0032496 response to lipopolysaccharide IEP 17625598
GO:0034142 toll-like receptor 4 signaling pathway IDA 17625598
GO:0042742 defense response to bacterium IEP 17625598
GO:0055074 calcium ion homeostasis NAS 16682778
genes like me logo Genes that share ontologies with S100A14: view

No data available for Pathways by source and SIGNOR curated interactions for S100A14 Gene

Drugs & Compounds for S100A14 Gene

No Compound Related Data Available

Transcripts for S100A14 Gene

Unigene Clusters for S100A14 Gene

S100 calcium binding protein A14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A14 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP3:
SP4: -

Relevant External Links for S100A14 Gene

GeneLoc Exon Structure for
S100A14
ECgene alternative splicing isoforms for
S100A14

Expression for S100A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A14 Gene

This gene is overexpressed in Esophagus - Mucosa (x25.3), Vagina (x6.4), Minor Salivary Gland (x4.1), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for S100A14 Gene

This gene is overexpressed in Cervix (31.3), Nasal epithelium (9.0), Saliva (8.2), and Hair follicle (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100A14 Gene



NURSA nuclear receptor signaling pathways regulating expression of S100A14 Gene:

S100A14

SOURCE GeneReport for Unigene cluster for S100A14 Gene:

Hs.288998

mRNA Expression by UniProt/SwissProt for S100A14 Gene:

Q9HCY8-S10AE_HUMAN
Tissue specificity: Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for S100A14 Gene

  • Pancreas(4.2)
  • Intestine(2.8)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with S100A14: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A14 Gene

Orthologs for S100A14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A14 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia S100A14 33 34
  • 91.91 (n)
oppossum
(Monodelphis domestica)
Mammalia S100A14 34
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A14 33 34
  • 87.91 (n)
mouse
(Mus musculus)
Mammalia S100a14 33 16 34
  • 87.79 (n)
zebrafish
(Danio rerio)
Actinopterygii s100a11 34
  • 33 (a)
OneToMany
Species where no ortholog for S100A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A14 Gene

ENSEMBL:
Gene Tree for S100A14 (if available)
TreeFam:
Gene Tree for S100A14 (if available)

Paralogs for S100A14 Gene

Paralogs for S100A14 Gene

(5) SIMAP similar genes for S100A14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A14: view

Variants for S100A14 Gene

Sequence variations from dbSNP and Humsavar for S100A14 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001624922 -- 153,615,290(-) A/G coding_sequence_variant, missense_variant
rs1001836786 -- 153,615,047(-) C/A intron_variant
rs1003413657 -- 153,617,881(-) C/T upstream_transcript_variant
rs1003633157 -- 153,617,791(-) C/T upstream_transcript_variant
rs1003665967 -- 153,618,139(-) C/T upstream_transcript_variant

Variation tolerance for S100A14 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A14 Gene

Human Gene Mutation Database (HGMD)
S100A14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A14 Gene

Disorders for S100A14 Gene

Additional Disease Information for S100A14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for S100A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A14 Gene

Publications for S100A14 Gene

  1. Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family. (PMID: 11944983) Pietas A … Petersen I (Genomics 2002) 2 3 4 58
  2. Solution structure and dynamics of human S100A14. (PMID: 23197251) Bertini I … Luchinat C (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2013) 3 4 58
  3. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. (PMID: 22032898) Sapkota D … Ibrahim SO (Oral oncology 2012) 3 4 58
  4. Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation. (PMID: 22451655) Chen H … Liu Z (The Journal of biological chemistry 2012) 3 4 58
  5. S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). (PMID: 21559403) Jin Q … Liu Z (PloS one 2011) 3 4 58

Products for S100A14 Gene

Sources for S100A14 Gene

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