S100A14 Gene
protein-coding GIFtS : 54
GCID: GC01 M153586
S100 calcium binding protein A14
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Aliasesfor S100A14 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases S100 Calcium Binding Protein A14 1 2 S100 Calcium-Binding Protein A142 3 S100A151 2 3 Breast Cancer Membrane Protein 842 BCMP841 2 5 Protein S100-A142 S1142 3
Export aliases for S100A14 gene to outside databases Previous GC identifers: GC07P101386 GC01U900004 GC01M9A0130 GC01M9A0399 GC01M150399 GC01M151853 GC01M124950
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Summariesfor S100A14 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for S100A14 : This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). (provided by RefSeq, Dec 2011)
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Genomic Viewsfor S100A14 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the S100A14 gene promoter: Brachyury MyoD FOXD1 MIF-1 STAT5A LCR-F1 AREB6 CREB deltaCREB Ik-1 Other transcription factors Search SABiosciences Chromatin IP Primers for S100A14 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A14
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.1 S100A14 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M153586: view genomic region
(about GC identifiers )
Start:
153,586,731 bp from pter
End:
153,589,462 bp from pter
Size:
2,732 bases
Orientation:
minus strand
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Proteinsfor S100A14 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S10AE_HUMAN, Q9HCY8 (See
protein sequence )Recommended Name: Protein S100-A14 Size : 104 amino acids; 11662 Da
Subcellular location : Cytoplasm
1 PDB 3D structure from and Proteopedia for S100A14 :2M0R (3D)
 
Secondary accessions : Q5RHT0Explore the universe of human proteins at neXtProt for S100A14: NX_Q9HCY8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9HCY8 S100A14 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_065723.1 ENSEMBL proteins: ENSP00000420296 ENSP00000357690 ENSP00000357691 ENSP00000340463 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
S100A14 for ontologies About GeneDecksing S100A14 Antibody Products: Assay Products for S100A14:
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Protein
Domains / Familiesfor S100A14 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
S100A14 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9HCY8 ProtoNet protein and cluster: Q9HCY8
1 Blocks protein family : IPB001751 Calcium-binding protein UniProtKB/Swiss-Prot: S10AE_HUMAN, Q9HCY8 Similarity : Belongs to the S-100 familySimilarity : Contains 1 EF-hand domain
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Functionfor S100A14 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for S100A14 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for S100A14OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: S100A14 (NM_020672 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100A14 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat S100A14
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A14
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
S100A14 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for S100A14 :
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Pathways & Interactionsfor S100A14 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for S100A14 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for S100A14 (Q9HCY8 2 , 3 ENSP00000340463 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
S100A14 for ontologies About GeneDecksing
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Drugs & Compoundsfor S100A14 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for S100A14 Search CenterWatch for drugs/clinical trials and news about S100A14 / S10AE
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Transcriptsfor S100A14 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for S100A14 gene: NM_020672.2 Unigene Cluster for S100A14:
S100 calcium binding protein A14 Hs.288998 [show with all ESTs ] Unigene Representative Sequence: BG674026 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000476873 ENST00000368701 ENST00000368702 (uc001fce.3 ) ENST00000368700 ENST00000469571 ENST00000344616 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for S100A14 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for S100A14OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: S100A14 (NM_020672 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100A14 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat S100A14
Additional cDNA sequence: AY007220.1 BC005019.1
5 DOTS entries : DT.107461 DT.100813530
DT.86840819 DT.92429565 DT.92429566 24/143 AceView cDNA sequences (see all 143 ):
NM_020672 BM765771 BU684216 BM765236 BM772161 BM824988 CA432850 AI825924 AI270315 AW264641 AI926478 AI569160 AA583999 CB142232 AI814942 BI335719 AY007220 BM745637 AI564980 AI950763 BM766050 BM765249 BM808804 BI064187 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for S100A14 About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d SP1 :   -     -   -                 SP2 :       -   -                 SP3 :                         SP4 :             -            
ECgene alternative splicing isoforms for S100A14
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Expression for S100A14 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section S100A14 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGGGAGAGG
About this image S100A14 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Sertoli cells Testis Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (Generation of mesend... )
See S100A14 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for S100A14 SOURCE GeneReport for Unigene cluster: Hs.288998 UniProtKB/Swiss-Prot: S10AE_HUMAN, Q9HCY8 Tissue specificity : Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, smallintestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes SABiosciences Custom PCR Arrays for S100A14 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for S100A14Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat S100A14 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat S100A14 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat S100A14 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A14
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Orthologsfor S100A14 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for S100A14 gene from 1/6 species (see all 6 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
S100A136
--
34(a)
1 → many
25(11271-11889)
ENSEMBL Gene Tree for S100A14 (if available)TreeFam Gene Tree for S100A14 (if available)
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Paralogsfor S100A14 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for S100A14 gene S100A13 2 5 SIMAP similar genes for S100A14 using alignment to 1 protein entry: S10AE_HUMAN :S100A13 S100A4 S100A10 S100A12 S100A16
S100A14 for paralogs About GeneDecksing
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Genomic Variantsfor S100A14 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for S100A14 (153586731 - 153589462 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for S100A14 2 CNVs : 84585 74724 3 Indels : 74726 84586 74725 Human Gene Mutation Database (HGMD) : S100A14 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing S100A14
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Disorders
/ Diseasesfor S100A14 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
S100A14 for disorders About GeneDecksing
OMIM gene information: 607986
OMIM disorders : --10 diseases for S100A14 : About MalaCards breast cancer esophageal squamous cell carcinoma squamous cell carcinoma atopic dermatitis dermatitis skin disease hepatocellular carcinoma esophagitis colorectal cancer carcinoma 1 disease from the University of Copenhagen DISEASES database for S100A14 :Small intestine adenocarcinoma Human Genome Epidemiology (HuGE) Navigator: S100A14 (1 document)Export disorders for S100A14 gene to outside databases
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Publicationsfor S100A14 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for S100A14 gene, integrated from 9 sources (see all 24 ): (articles sorted by number of sources associating them with S100A14) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family. (PubMed id 11944983) 1 , 2 , 3 Pietas A....Petersen I. (2002) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051) 1 Fang Y....Shen X. (2012) Involvement of S100A14 protein in cell invasion by aff ecting expression and function of matrix metalloproteinase (MMP)-2 via p53-depen dent transcriptional regulation. (PubMed id 22451655) 1 Chen H....Liu Z. (2012) S100A14 inhibits proliferation of oral carcinoma deri ved cells through G1-arrest. (PubMed id 22032898) 1 Sapkota D....Ibrahim S.O. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) S100A14 stimulates cell proliferation and induces cel l apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). (PubMed id 21559403) 1 Jin Q....Liu Z. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for S100A14 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing S100A14 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing S100A14 gene
(According to HUGE )
About This Section --
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Specialized Databases showing S100A14 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for S100A14 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for S100A14 gene: Search GeneIP for patents involving S100A14 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor S100A14 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for S100A14 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for S100A14 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for S100A14 OriGene Protein Over-expression Lysate for S100A14 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for S100A14 OriGene 3'-UTR Clone for S100A14 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for S100A14 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for S100A14 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for S100A14 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for S100A14 OriGene Custom Protein Services for S100A14 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat S100A14 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing S100A14 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A14 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat S100A14 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat S100A14 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat S100A14
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S100A14 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A14
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat S100A14
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