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Aliases for S100A14 Gene

Aliases for S100A14 Gene

  • S100 Calcium Binding Protein A14 2 3 5
  • S100 Calcium-Binding Protein A14 3 4
  • S100A15 3 4
  • S114 3 4
  • Breast Cancer Membrane Protein 84 3
  • BCMP84 3

External Ids for S100A14 Gene

Previous GeneCards Identifiers for S100A14 Gene

  • GC07P101386
  • GC01U900004
  • GC01M9A0130
  • GC01M9A0399
  • GC01M150399
  • GC01M151853
  • GC01M153586
  • GC01M124950

Summaries for S100A14 Gene

Entrez Gene Summary for S100A14 Gene

  • This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

GeneCards Summary for S100A14 Gene

S100A14 (S100 Calcium Binding Protein A14) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and chemokine receptor binding. An important paralog of this gene is S100A13.

UniProtKB/Swiss-Prot for S100A14 Gene

  • Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A14 Gene

Genomics for S100A14 Gene

Regulatory Elements for S100A14 Gene

Promoters for S100A14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S100A14 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A14 Gene

Chromosome:
1
Start:
153,614,255 bp from pter
End:
153,616,986 bp from pter
Size:
2,732 bases
Orientation:
Minus strand

Genomic View for S100A14 Gene

Genes around S100A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A14 Gene

Proteins for S100A14 Gene

  • Protein details for S100A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCY8-S10AE_HUMAN
    Recommended name:
    Protein S100-A14
    Protein Accession:
    Q9HCY8
    Secondary Accessions:
    • Q5RHT0

    Protein attributes for S100A14 Gene

    Size:
    104 amino acids
    Molecular mass:
    11662 Da
    Quaternary structure:
    • Homodimer. Interacts with AGER.

    Three dimensional structures from OCA and Proteopedia for S100A14 Gene

neXtProt entry for S100A14 Gene

Proteomics data for S100A14 Gene at MOPED

Post-translational modifications for S100A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A14 Gene

Antibody Products

No data available for DME Specific Peptides for S100A14 Gene

Domains & Families for S100A14 Gene

Gene Families for S100A14 Gene

Protein Domains for S100A14 Gene

Suggested Antigen Peptide Sequences for S100A14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCY8

UniProtKB/Swiss-Prot:

S10AE_HUMAN :
  • Contains 1 EF-hand domain.
  • Belongs to the S-100 family.
Domain:
  • Contains 1 EF-hand domain.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A14: view

Function for S100A14 Gene

Molecular function for S100A14 Gene

UniProtKB/Swiss-Prot Function:
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
genes like me logo Genes that share phenotypes with S100A14: view

Animal Models for S100A14 Gene

MGI Knock Outs for S100A14:

Animal Model Products

miRNA for S100A14 Gene

miRTarBase miRNAs that target S100A14

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A14 Gene

Localization for S100A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A14 Gene COMPARTMENTS Subcellular localization image for S100A14 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0030054 cell junction IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with S100A14: view

Pathways & Interactions for S100A14 Gene

SuperPathways for S100A14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0032496 response to lipopolysaccharide IEP 17625598
GO:0042742 defense response to bacterium IEP 17625598
GO:0090026 positive regulation of monocyte chemotaxis IDA 18606705
genes like me logo Genes that share ontologies with S100A14: view

No data available for Pathways by source and SIGNOR curated interactions for S100A14 Gene

Drugs & Compounds for S100A14 Gene

No Compound Related Data Available

Transcripts for S100A14 Gene

Unigene Clusters for S100A14 Gene

S100 calcium binding protein A14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A14 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP3:
SP4: -

Relevant External Links for S100A14 Gene

GeneLoc Exon Structure for
S100A14
ECgene alternative splicing isoforms for
S100A14

Expression for S100A14 Gene

mRNA expression in normal human tissues for S100A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A14 Gene

This gene is overexpressed in Esophagus - Mucosa (x25.3), Vagina (x6.4), Minor Salivary Gland (x4.1), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for S100A14 Gene

This gene is overexpressed in Cervix (31.3), Nasal epithelium (9.0), Saliva (8.2), and Hair follicle (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A14 Gene



SOURCE GeneReport for Unigene cluster for S100A14 Gene Hs.288998

mRNA Expression by UniProt/SwissProt for S100A14 Gene

Q9HCY8-S10AE_HUMAN
Tissue specificity: Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with S100A14: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for S100A14 Gene

Orthologs for S100A14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A14 35
  • 91.91 (n)
  • 94.17 (a)
S100A14 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A14 35
  • 87.91 (n)
  • 88.24 (a)
S100A14 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100a14 35
  • 87.79 (n)
  • 93.07 (a)
S100a14 16
S100a14 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100A14 35
  • 99.68 (n)
  • 100 (a)
S100A14 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A14 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii s100a11 36
  • 33 (a)
OneToMany
Species with no ortholog for S100A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A14 Gene

ENSEMBL:
Gene Tree for S100A14 (if available)
TreeFam:
Gene Tree for S100A14 (if available)

Paralogs for S100A14 Gene

Paralogs for S100A14 Gene

(5) SIMAP similar genes for S100A14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A14: view

Variants for S100A14 Gene

Sequence variations from dbSNP and Humsavar for S100A14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4072425 -- 153,616,367(+) GAAGG(A/G)AGGGG upstream-variant-2KB
rs4073663 -- 153,618,094(-) agtta(A/G)ttctc upstream-variant-2KB
rs9330298 -- 153,617,778(+) TGCTC(A/C)CTCTG upstream-variant-2KB
rs9792963 -- 153,615,732(+) GGCAA(A/G)GCCAA intron-variant
rs9792967 -- 153,615,803(+) GAGCA(A/G)AAAGG intron-variant

Variation tolerance for S100A14 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A14 Gene

HapMap Linkage Disequilibrium report
S100A14
Human Gene Mutation Database (HGMD)
S100A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A14 Gene

Disorders for S100A14 Gene

Relevant External Links for S100A14

Genetic Association Database (GAD)
S100A14
Human Genome Epidemiology (HuGE) Navigator
S100A14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A14

No disorders were found for S100A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A14 Gene

Publications for S100A14 Gene

  1. Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family. (PMID: 11944983) Pietas A. … Petersen I. (Genomics 2002) 2 3 4 67
  2. Downregulation of 425G>a variant of calcium-binding protein S100A14 associated with poor differentiation and prognosis in gastric cancer. (PMID: 25266115) Zhang Q. … Lu Y. (J. Cancer Res. Clin. Oncol. 2015) 3
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. S100A14, a member of the EF-hand calcium-binding proteins, is overexpressed in breast cancer and acts as a modulator of HER2 signaling. (PMID: 24285542) Xu C. … Liu Z. (J. Biol. Chem. 2014) 3

Products for S100A14 Gene

Sources for S100A14 Gene

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