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S100A13 Gene

protein-coding   GIFtS: 59

GC01M151857
S100 calcium binding protein A13
(Previous name: S100 calcium-binding protein A13 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000034802 2
Descriptions
S100 calcium binding protein A13 2
S100 calcium-binding protein A13 1, 2, 3
External Ids
HGNC: 104901
Entrez Gene: 62842
UniProtKB: Q995843
Ensembl: ENSG000001891717
Search outside databases for aliases for S100A13 gene

Previous GC identifers: GC01U990151 GC01M9A0135 GC01M9A0404 GC01M150404

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A13:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a
high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with
other family members in the nucleus and in stress fibers, suggesting diverse functions in signal
transduction. Multiple alternatively spliced transcript variants encoding the same protein have
been found for this gene. [provided by RefSeq]

Gene Wiki entry for S100A13
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A13 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151857:     (about GC identifiers)

Start:
151,857,899 bp from pter
End:
151,873,192 bp from pter
Size:
15,294 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S10AD_HUMAN, Q99584 (See protein sequence)
Recommended Name: Protein S100-A13  
Size: 98 amino acids; 11471 Da
PDB structures from and Proteopedia :
1YUR (3D)    1YUS (3D)    1YUT (3D)    1YUU (3D)    2EGD (3D)    2H2K (3D)    2K8M (3D)    
Secondary accessions: Q52PI9 Q6FGF8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (5 alternative transcripts): 
    NP_001019381.1  NP_001019382.1  NP_001019383.1  NP_001019384.1  NP_005970.1  


    ENSEMBL proteins: 
    ENSP00000357688 ENSP00000376400 ENSP00000376399 ENSP00000376398 ENSP00000344822 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for S100A13
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (S100 Calcium Binding Protein A13)
    Human Recombinant Proteins from Abnova (S100A13)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    About this table

    Antibodies for S100A13: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for S100A13
    R&D Systems Antibodies for S100A13
    Antibodies from Abcam (S100 Calcium Binding Protein A13), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (S100A13)
    Novus Biologicals Antibodies for S100A13

    Assays for S100A13: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR018247 EF_HAND_1
     IPR011992 EF-Hand_type
     IPR013787 S100_Ca_bd_sub
     IPR001751 S100_Ca_bd


       GeneDecks  S100A13 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q99584

    ProtoNet protein and cluster: Q99584

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10AD_HUMAN, Q99584
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A13)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001024210

                  Applied Biosystems Silencer® siRNAs for S100A13

                  Sigma-Aldrich siRNA for S100A13  
                         Sigma-Aldrich shRNA for S100A13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for S100A13
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001024210
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001024210
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_001024210 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001024213

    Genatlas biochemistry entry for S100A13:
    S100 calcium binding protein A13,expressed in skeletal muscle,heart,kidney,ovary,small
    intestine,pancreas,involved in the regulation of FGF1 and SYT1 release in response to temperature
    stress

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509 calcium ion binding TAS8878558
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  S100A13 


    5/7 Interacting proteins for S100A13 (ENSP000003576883) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYT1ENSP000002612053STRING (score=.987)
    FGF1ENSP000003385483STRING (score=.964)
    IL1AENSP000002633393STRING (score=.76)
    S100A2ENSP000003576973STRING (score=.749)
    PBRM1ENSP000002963023STRING (score=.743)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030154 cell differentiation NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for S100A13
    1 Novoseek chemical compound relationship for S100A13 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 39.27 8 18164517 (2), 12746488 (1), 16773219 (1), 12754378 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A13)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001024210

                  Sigma-Aldrich siRNA for S100A13  
                         Sigma-Aldrich shRNA for S100A13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001024210  NM_001024211  NM_001024212  NM_001024213  NM_005979  

    REFSEQ mRNAs for S100A13 gene (5 alternative transcripts): 

    NM_001024210.1   NM_001024211.1   NM_001024212.1   NM_001024213.1   NM_005979.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001024210  NM_001024211  NM_001024212  NM_001024213  NM_005979  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001024210
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001024210
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_001024210 

    Additional cDNA sequence: 

    AY987392.1 BC000632.2 BC068064.1 BC070291.1 BC114379.1 BT006724.1 CR542149.1 X99920.1 

    17 DOTS entries:

    DT.91660387  DT.121412421  DT.454559  DT.91749687  DT.100885878  DT.100038535  DT.121412415  DT.97858893 
    DT.92448317  DT.102840749  DT.97791395  DT.100032143  DT.85105380  DT.95083206  DT.99941971  DT.95172475 
    DT.97861882 

    24/275 AceView cDNA sequences (see all 275 ):

    BM918594 AA358375 CA306368 BF739761 CB227637 BQ082077 AA976918 AA366085 
    BU681438 AI150597 AI192334 F34753 N25492 BE300559 CB410059 AI056032 
    BU197189 N93557 BX092408 BX117925 AL702514 BE465897 BQ447546 X99920 

    highest scoring ESTs for S100A13:

    AA814441 AA833741 AI027357 AW975850 AA024487 AA025332 AA026881 AA070489 AA150913 AA177007 

    Unigene Cluster for S100A13:

    S100 calcium binding protein A13
    Hs.516505  [show with all ESTs]
    Unigene Representative Sequence: BF664967


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for S100A13 (see all 10 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                          -           -     -     -     -           -                                 
    SP2:                    -     -           -     -     -     -           -                                 
    SP3:                          -     -     -     -     -     -           -                                 
    SP4:                                      -     -     -     -           -                                 
    SP5:                                            -     -     -           -                                 

    About this scheme

    ECgene alternative splicing isoforms for S100A13

    5 Ensembl transcripts including schematic representations:
    ENST00000368699  ENST00000392624  ENST00000392623  ENST00000392622  ENST00000339556  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    S100A13 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for S100A13

    1 / 2 / 3

    3 probe-sets matching S100A13 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39712_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AI541308 0.40 1.00 0.76 1

    202598_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005979 0.60 1.00 0.82 1

    202598_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  S100A13 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTCAAGTGC

    SOURCE GeneReport for Unigene cluster: Hs.516505

    UniProtKB/Swiss-Prot: S10AD_HUMAN, Q99584
    Tissue specificity: Expressed in heart and skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for S100A13 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4904571   -- similar to S100 calcium-binding protein A13 86.05(n)
    86.73(a)
    490457  XM_547579.2  XP_547579.2 
    chimpanzee
    (Pan troglodytes)
    S100A131   -- S100 calcium binding protein A13 99.66(n)
    100(a)
    457324  XM_001140557.1  XP_001140557.1 
    cow
    (Bos taurus)
    S100A131   -- 8KDa amlexanox-binding protein 85.71(n)
    89.8(a)
    404146  NM_205800.1  NP_991369.1 
    rat
    (Rattus norvegicus)
    S100a131   -- S100 calcium binding protein A13 82.65(n)
    89.8(a)
    295213  XM_215607.3  XP_215607.1 
    mouse
    (Mus musculus)
    S100a131, 5 3 (43.60 cM)5
    S100 calcium binding protein A131, 5 81.63(n)1
    82.65(a)1
    201961  NM_009113.31  NP_033139.11 
     AA0334785  AK0027555  (see all 11)
    About this table        Species with no ortholog for S100A13

    ENSEMBL Gene Tree for S100A13
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for S100A13 gene
    S100A142  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/38 NCBI SNPs in S100A13 are shown (see all 38 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 28)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs284165291,2
    C151862005(+) CACACA/GTACAG 5 -- int10--------
    --
    rs93302991,2
    C151858394(+) atggcC/Tgctta 5 -- int10--------
    --
    rs93303001,2
    C151859157(+) tgaggC/Tgggcg 5 -- int10--------
    --
    rs97297731,2
    C151861247(+) ggcagA/Gtcatc 5 -- int10--------
    --
    rs287547331,2
    C151864718(+) TTCCAC/TATATG 5 -- int10--------
    --
    rs93303011,2
    C151860988(+) aaaTTG/TAAGTT 5 -- int10--------
    --
    rs97267531,2
    C151858276(+) AGAAGA/GAGGCT 5 -- int1 trp30--------
    --
    rs730099751,2
    --151857970(+) CCCTGA/CCCACC 5 -- ut310--------
    --
    rs113881,2
    --151865486(-) GGCCGG/TAAGGA 5 R/R syn1 ese31Minor allele frequency- T:0.00MN 184
    --
    rs286375681,2
    --151862542(+) GTGCAG/TTGGTG 5 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for S100A13 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 601989

    2 Novoseek disease relationships for S100A13 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0.00 1 9712836 (1)
    tumors 0.00 1 17268060 (1)
    About this table

    1 PharmGKB disease relationship for S100A13 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/37 PubMed articles for S100A13 gene (see all 37 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6284 HGNC: 10490 AceView: S100A13 Ensembl:ENSG00000189171 euGenes: HUgn6284
    ECgene: S100A13 H-InvDB: S100A13
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for S100A13:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Millipore Preclinical / Clinical Development Services
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     Predesigned and custom siRNAs for S100A13 Antibodies for S100A13
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for S100A13 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search OriGene for S100A13
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     Antibodies for S100A13

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