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Aliases & Descriptions for S100A13
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000034802 2
Descriptions S100 calcium binding protein A13 2 S100 calcium-binding protein A13 1 , 2 , 3
Search outside databases for aliases for S100A13 genePrevious GC identifers: GC01U990151 GC01M9A0135 GC01M9A0404 GC01M150404
Summaries for S100A13 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for S100A13 : The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-handcalcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a widerange of cells, and involved in the regulation of a number of cellular processes such as cellcycle progression and differentiation. S100 genes include at least 13 members which are located asa cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with ahigh expression level in thyroid gland. In smooth muscle cells, this protein co-expresses withother family members in the nucleus and in stress fibers, suggesting diverse functions in signaltransduction. Multiple alternatively spliced transcript variants encoding the same protein havebeen found for this gene. [provided by RefSeq] Gene Wiki entry for S100A13
Genomic Location for S100A13
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the S100A13 gene Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21 S100A13 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M151857:
(about GC identifiers )
Start:
151,857,899 bp from pter
End:
151,873,192 bp from pter
Size:
15,294 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for S100A13
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: S10AD_HUMAN, Q99584 (See
protein sequence )Recommended Name: Protein S100-A13 Size : 98 amino acids; 11471 Da
PDB structures from and Proteopedia : 1YUR (3D)
 1YUS (3D)
 1YUT (3D)
 1YUU (3D)
 2EGD (3D)
 2H2K (3D)
 2K8M (3D)
 
Secondary accessions : Q52PI9 Q6FGF8
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (5 alternative transcripts):
NP_001019381.1 NP_001019382.1 NP_001019383.1 NP_001019384.1 NP_005970.1 ENSEMBL proteins: ENSP00000357688 ENSP00000376400 ENSP00000376399 ENSP00000376398 ENSP00000344822 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND --
About this table Antibodies for S100A13: Assays for S100A13:
Protein
Domains/ Families for S100A13(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q99584 ProtoNet protein and cluster: Q99584
1 Blocks protein family : IPB001751 Calcium-binding protein UniProtKB/Swiss-Prot: S10AD_HUMAN, Q99584 Similarity : Belongs to the S-100 familySimilarity : Contains 2 EF-hand domains
Gene Function for S100A13
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_001024210 Applied Biosystems Silencer ® siRNAs for S100A13 Sigma-Aldrich siRNA for S100A13 Sigma-Aldrich shRNA for S100A13 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024210                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024210                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001024210  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001024213 Genatlas biochemistry entry for S100A13 :S100 calcium binding protein A13,expressed in skeletal muscle,heart,kidney,ovary,smallintestine,pancreas,involved in the regulation of FGF1 and SYT1 release in response to temperaturestress 1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for S100A13
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for S100A13 5/7 Interacting proteins for S100A13 (ENSP00000357688 3 ) via UniProtKB, MINT, and/or STRING (see all 7
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0030154 cell differentiation
NAS --
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Drugs & Compounds for S100A13 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for S100A13 1 Novoseek chemical compound relationship for S100A13 gene
About this table
Transcripts for S100A13(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_001024210 Sigma-Aldrich siRNA for S100A13 Sigma-Aldrich shRNA for S100A13 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001024210 NM_001024211 NM_001024212 NM_001024213 NM_005979
REFSEQ mRNAs for S100A13 gene (5 alternative transcripts): NM_001024210.1 NM_001024211.1 NM_001024212.1 NM_001024213.1 NM_005979.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001024210 NM_001024211 NM_001024212 NM_001024213 NM_005979
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024210                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024210                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001024210  
Additional cDNA sequence: AY987392.1 BC000632.2 BC068064.1 BC070291.1 BC114379.1 BT006724.1 CR542149.1 X99920.1
17 DOTS entries : DT.91660387 DT.121412421 DT.454559 DT.91749687 DT.100885878 DT.100038535 DT.121412415 DT.97858893 DT.92448317 DT.102840749 DT.97791395 DT.100032143 DT.85105380 DT.95083206 DT.99941971 DT.95172475 DT.97861882
24/275 AceView cDNA sequences (see all 275
):BM918594 AA358375 CA306368 BF739761 CB227637 BQ082077 AA976918 AA366085 BU681438 AI150597 AI192334 F34753 N25492 BE300559 CB410059 AI056032 BU197189 N93557 BX092408 BX117925 AL702514 BE465897 BQ447546 X99920
highest scoring ESTs for S100A13 :AA814441 AA833741 AI027357 AW975850 AA024487 AA025332 AA026881 AA070489 AA150913 AA177007
Unigene Cluster for S100A13: S100 calcium binding protein A13 Hs.516505 [show with all ESTs ] Unigene Representative Sequence: BF664967 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for S100A13 (see all 10
) ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e SP1 :         -     -   -   -   -     -             SP2 :       -   -     -   -   -   -     -             SP3 :         -   -   -   -   -   -     -             SP4 :             -   -   -   -     -             SP5 :               -   -   -     -            
About this scheme ECgene alternative splicing isoforms for S100A13 5 Ensembl transcripts including schematic representations : ENST00000368699
ENST00000392624
ENST00000392623
ENST00000392622
ENST00000339556
Expression for S100A13
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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S100A13 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for S100A13 1 / 2 / 3
3 probe-sets matching S100A13 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTTCAAGTGCSOURCE GeneReport for Unigene cluster: Hs.516505 UniProtKB/Swiss-Prot: S10AD_HUMAN, Q99584 Tissue specificity : Expressed in heart and skeletal muscle
Orthologs for S100A13
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for S100A13 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for S100A13 ENSEMBL Gene Tree for S100A13 Paralogs for S100A13 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for S100A13 gene S100A14 2
SNPs/Variants for S100A13 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for S100A13 (up to first 250kb)
Disorders & Mutations for S100A13
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601989 2 Novoseek disease relationships for S100A13 gene
About this table 1 PharmGKB disease relationship for S100A13 gene About this table
Medical News for S100A13 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for S100A13 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/37 PubMed articles for S100A13 gene (see all 37
): Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family. (PubMed id 8878558) 1, 3, 4 Wicki R.... Heizmann C.W. (1996) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PubMed id 8985590) 2, 3 Wicki R.... Heizmann C.W. (1996) S100A13, a new marker of angiogenesis in human astrocytic gliomas. (PubMed id 16773219) 1, 3 Landriscina M....Barone C. (2006) Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis. (PubMed id 15821778) 1, 3 Hayrabedyan S....Kehayov I. (2005) S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. (PubMed id 12746488) 1, 3 Mandinova A....Maciag T. (2003) S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. (PubMed id 9712836) 1, 3 Mouta Carreira C....Maciag T. (1998) Differential expression of S100 proteins in the developing human hippocampus and temporal cortex. (PubMed id 12645008) 1, 3 Chan W.Y....Yew D.T. (2003) Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution. (PubMed id 18259052) 3 Imai F.L....Tanokura M. (2008)
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Genome Databases showing S100A13
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing S100A13
(According to HUGE )
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Specialized Databases showing S100A13 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for S100A13 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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