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Aliases for S100A13 Gene

Aliases for S100A13 Gene

  • S100 Calcium Binding Protein A13 2 3 5
  • S100 Calcium-Binding Protein A13 2 4

External Ids for S100A13 Gene

Previous GeneCards Identifiers for S100A13 Gene

  • GC01U990151
  • GC01M9A0135
  • GC01M9A0404
  • GC01M150404
  • GC01M151857
  • GC01M153591
  • GC01M124954

Summaries for S100A13 Gene

Entrez Gene Summary for S100A13 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A13 Gene

S100A13 (S100 Calcium Binding Protein A13) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is S100A14.

UniProtKB/Swiss-Prot for S100A13 Gene

  • Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).

Gene Wiki entry for S100A13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A13 Gene

Genomics for S100A13 Gene

Regulatory Elements for S100A13 Gene

Enhancers for S100A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G153561 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +68.5 68531 8.8 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D GLIS1 NBN NR2C1 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1 CHTOP
GH01G153552 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +80.2 80224 1.8 HDAC1 RB1 DMAP1 FEZF1 ZFHX2 ZNF766 ZNF366 ZBTB48 POLR2A PRDM10 S100A3 CHTOP S100A13 S100A16 S100A14 S100A1 INTS3 ENSG00000233222 ENSG00000243613 ILF2
GH01G153596 1.5 Ensembl ENCODE dbSUPER 11.2 +35.8 35837 3.5 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF48 YY1 ETS1 GTF3C2 GATA2 CHTOP S100A13 ENSG00000272030 S100A16 SLC27A3 GC01P153610 PIR44602
GH01G153489 1.5 Ensembl ENCODE dbSUPER 10.1 +143.3 143265 2.1 SIN3A FEZF1 ZNF2 FOS DEK SP3 REST TSHZ1 ZNF623 ZNF518A PGLYRP4 S100A9 RNU6-160P S100A1 CHTOP S100A13 PGLYRP3 RN7SL44P S100A3 GC01M153500
GH01G153539 1.3 ENCODE dbSUPER 10.6 +88.6 88561 12.0 PKNOX1 ARID4B SIN3A DMAP1 CBX5 FOS DEK SP3 SP5 JUNB S100A3 S100A16 S100A14 S100A1 S100A13 CHTOP INTS3 ENSG00000243613 ENSG00000233222 ILF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S100A13 on UCSC Golden Path with GeneCards custom track

Promoters for S100A13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013820 -608 1801 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1

Transcription factor binding sites by QIAGEN in the S100A13 gene promoter:

Genomic Location for S100A13 Gene

Chromosome:
1
Start:
153,618,787 bp from pter
End:
153,634,092 bp from pter
Size:
15,306 bases
Orientation:
Minus strand

Genomic View for S100A13 Gene

Genes around S100A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A13 Gene

Proteins for S100A13 Gene

  • Protein details for S100A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99584-S10AD_HUMAN
    Recommended name:
    Protein S100-A13
    Protein Accession:
    Q99584
    Secondary Accessions:
    • Q52PI9
    • Q6FGF8

    Protein attributes for S100A13 Gene

    Size:
    98 amino acids
    Molecular mass:
    11471 Da
    Quaternary structure:
    • Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for S100A13 Gene

neXtProt entry for S100A13 Gene

Post-translational modifications for S100A13 Gene

  • Ubiquitination at Lys61
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for S100A13

No data available for DME Specific Peptides for S100A13 Gene

Domains & Families for S100A13 Gene

Gene Families for S100A13 Gene

Protein Domains for S100A13 Gene

Suggested Antigen Peptide Sequences for S100A13 Gene

Graphical View of Domain Structure for InterPro Entry

Q99584

UniProtKB/Swiss-Prot:

S10AD_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A13: view

Function for S100A13 Gene

Molecular function for S100A13 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A13,expressed in skeletal muscle,heart,kidney,ovary,small intestine,pancreas,involved in the regulation of FGF1 and SYT1 release in response to temperature stress
UniProtKB/Swiss-Prot Function:
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).

Gene Ontology (GO) - Molecular Function for S100A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IDA 12746488
GO:0005509 calcium ion binding IDA 16145699
GO:0005515 protein binding IPI 12746488
GO:0008270 zinc ion binding IDA 12118070
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with S100A13: view
genes like me logo Genes that share phenotypes with S100A13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for S100A13 Gene

Localization for S100A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A13 Gene

Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A13 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
lysosome 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for S100A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 12746488
GO:0005634 nucleus IDA 12118070
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 15821778
genes like me logo Genes that share ontologies with S100A13: view

Pathways & Interactions for S100A13 Gene

SuperPathways for S100A13 Gene

No Data Available

SIGNOR curated interactions for S100A13 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for S100A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008360 regulation of cell shape IEA --
GO:0015031 protein transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 15033494
genes like me logo Genes that share ontologies with S100A13: view

No data available for Pathways by source for S100A13 Gene

Drugs & Compounds for S100A13 Gene

(4) Drugs for S100A13 Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlexanox Approved, Investigational Pharma Target, antagonist Inhibitor of TBK1 and IKKeta; antiallergic agent 3
Olopatadine Approved Pharma Target, other/unknown 0
Patanase Approved April 2008 Pharma 0
genes like me logo Genes that share compounds with S100A13: view

Transcripts for S100A13 Gene

Unigene Clusters for S100A13 Gene

S100 calcium binding protein A13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7:
SP8: -
SP9: -
SP10: -

Relevant External Links for S100A13 Gene

GeneLoc Exon Structure for
S100A13
ECgene alternative splicing isoforms for
S100A13

Expression for S100A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A13 Gene

Protein differential expression in normal tissues from HIPED for S100A13 Gene

This gene is overexpressed in Nasopharynx (13.5) and Nasal epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100A13 Gene



Protein tissue co-expression partners for S100A13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A13 Gene:

S100A13

SOURCE GeneReport for Unigene cluster for S100A13 Gene:

Hs.516505

mRNA Expression by UniProt/SwissProt for S100A13 Gene:

Q99584-S10AD_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for S100A13 Gene

  • Thyroid gland(4.5)
  • Skin(4.3)
  • Eye(4.2)
  • Heart(2.7)
  • Nervous system(2.7)
  • Lung(2.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with S100A13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A13 Gene

Orthologs for S100A13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A13 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia S100A13 34 35
  • 86.05 (n)
cow
(Bos Taurus)
Mammalia S100A13 34 35
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia S100a13 34
  • 83.71 (n)
mouse
(Mus musculus)
Mammalia S100a13 34 16 35
  • 81.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia S100A13 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A13 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves S100A13 34 35
  • 62.84 (n)
zebrafish
(Danio rerio)
Actinopterygii s100a11 35
  • 38 (a)
OneToMany
Species where no ortholog for S100A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A13 Gene

ENSEMBL:
Gene Tree for S100A13 (if available)
TreeFam:
Gene Tree for S100A13 (if available)

Paralogs for S100A13 Gene

Paralogs for S100A13 Gene

(16) SIMAP similar genes for S100A13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with S100A13: view

Variants for S100A13 Gene

Sequence variations from dbSNP and Humsavar for S100A13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000143162 -- 153,620,784(+) TTGAG(G/T)CCAGG intron-variant
rs1000212278 -- 153,619,295(+) TGGCT(A/G)CTTAC intron-variant
rs1000284570 -- 153,620,411(+) AGCCG(A/C)GATCA intron-variant
rs1000918441 -- 153,622,332(+) TGCCA(C/T)TGCAC intron-variant
rs1001120163 -- 153,632,245(+) ACTAT(A/G)AAACC intron-variant, downstream-variant-500B, upstream-variant-2KB

Variation tolerance for S100A13 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A13 Gene

Disorders for S100A13 Gene

Relevant External Links for S100A13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A13

No disorders were found for S100A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A13 Gene

Publications for S100A13 Gene

  1. S100A13 mediates the copper-dependent stress-induced release of IL- 1alpha from both human U937 and murine NIH 3T3 cells. (PMID: 12746488) Mandinova A. … Maciag T. (J. Cell Sci. 2003) 3 4 22 64
  2. Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family. (PMID: 8878558) Wicki R. … Heizmann C.W. (Biochem. Biophys. Res. Commun. 1996) 3 4 22 64
  3. Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells. (PMID: 20863990) Cao R. … Zhong J. (J. Formos. Med. Assoc. 2010) 3 4 64
  4. S100A13 is a new angiogenic marker in human melanoma. (PMID: 20208480) Massi D. … Tarantini F. (Mod. Pathol. 2010) 3 22 64
  5. S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway. (PMID: 19284995) Mohan S.K. … Yu C. (Biochem. Biophys. Res. Commun. 2009) 3 4 64

Products for S100A13 Gene

Sources for S100A13 Gene

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