S100A12 Gene
protein-coding GIFtS : 56
GC01M151612
S100 calcium binding protein A12 (Previous names: S100 calcium-binding protein A12 (calgranulin C), S100 calcium binding protein A12 (calgranulin C) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for S100A12
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CAAF1 1 , 2 , 3 , 5 CAGC 1 , 2 , 3 CGRP 1 , 2 , 3 , 5 Calgranulin-C 3 ENRAGE 1 , 2 MRP6 1 , 2 OTTHUMP00000015332 2 p6 1 , 2 , 3
Descriptions Calcium-binding protein in amniotic fluid 1 3 Neutrophil S100 protein 3 S100 calcium binding protein A12 2 S100 calcium binding protein A12 (calgranulin C) 1 S100 calcium-binding protein A12 2 , 3 S100 calcium-binding protein A12 (calgranulin C) 1 , 2 calgranulin C 2
Search outside databases for aliases for S100A12 genePrevious GC identifers: GC01M151162 GC01M149128 GC01M150121 GC01M150562 GC01M150159
Summaries for S100A12 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for S100A12 : The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-handcalcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a widerange of cells, and involved in the regulation of a number of cellular processes such as cellcycle progression and differentiation. S100 genes include at least 13 members which are located asa cluster on chromosome 1q21. This protein is proposed to be involved in specificcalcium-dependent signal transduction pathways and its regulatory effect on cytoskeletalcomponents may modulate various neutrophil activities. [provided by RefSeq] UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 Function : Calcitermin possesses antifungal activity against C.albicans and is also active againstE.coli and P.aeruginosa but not L.monocytogenes and S.aureus
Gene Wiki entry for S100A12
Genomic Location for S100A12
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the S100A12 gene Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21 S100A12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M151612:
(about GC identifiers )
Start:
151,612,805 bp from pter
End:
151,614,699 bp from pter
Size:
1,895 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for S100A12
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 (See
protein sequence )Recommended Name: Protein S100-A12 Size : 92 amino acids; 10575 Da
Subunit : Homodimer
Mass spectrometry : Mass=10444; Method=Electrospray; Range=2-92; Source=PubMed:11522286;
Mass spectrometry : Mass=1688.9; Method=MALDI; Range=78-92; Source=PubMed:11522286;
PDB structures from and Proteopedia : 1E8A (3D)
 1GQM (3D)
 1ODB (3D)
 
Secondary accessions : P83219 Q5SY66 Q7M4R1
REFSEQ proteins: NP_005612.1 ENSEMBL proteins: ENSP00000357726 ENSP00000357725 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: S100A12 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for S100A12: Assays for S100A12:
Protein
Domains/ Families for S100A12(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P80511 ProtoNet protein and cluster: P80511
1 Blocks protein family : IPB001751 Calcium-binding protein UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 Similarity : Belongs to the S-101 familySimilarity : Contains 2 EF-hand domains
Gene Function for S100A12
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005621 Applied Biosystems Silencer ® siRNAs for S100A12 Sigma-Aldrich siRNA for S100A12 Sigma-Aldrich shRNA for S100A12 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005621                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005621                                  untagged cDNA clone in CMV expression vector: NM_005621  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005621 UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 Function : Calcitermin possesses antifungal activity against C.albicans and is also active againstE.coli and P.aeruginosa but not L.monocytogenes and S.aureus
Genatlas biochemistry entry for S100A12 :S100 calcium binding protein A12,6.5kDa,expressed exclusively by granulocytes,independently fromS100A8 and S100A9,identical to corneal associated antigen (COAG) 2 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for S100A12
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for S100A12 5 Interacting proteins for S100A12 (ENSP00000357726 3 ) via UniProtKB, MINT, and/or STRING About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for S100A12 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for S100A12 6 Novoseek chemical compound relationships for S100A12 gene
About this table 2 PharmGKB drug compound relationships for S100A12 gene About this table
Transcripts for S100A12(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005621 Sigma-Aldrich siRNA for S100A12 Sigma-Aldrich shRNA for S100A12 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005621
REFSEQ mRNAs for S100A12 gene: NM_005621.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005621
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005621                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005621                                  untagged cDNA clone in CMV expression vector: NM_005621  
Additional cDNA sequence: BC070294.1 D49549.1 D83664.1 X97859.1
2 DOTS entries : DT.412396 DT.100726392
24/43 AceView cDNA sequences (see all 43
):X97859 D83664 BX092856 AA321239 NM_005621 AU100319 AW468479 AA313230 AA707079 AI161013 AJ706429 BC070294 AI718758 AI735194 AW952195 AJ713981 AJ706621 AJ706358 AI365228 AW016082 AA984879 AA700005 AJ706518 AI056983
highest scoring ESTs for S100A12 :D83664 AA203475 AA313230 AA321239 AJ706358 AJ713981 AU100319 AV715719 AV715975 AV758762
Unigene Cluster for S100A12: S100 calcium binding protein A12 Hs.19413 [show with all ESTs ] Unigene Representative Sequence: AV758762 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000368737
ENST00000368736
Expression for S100A12
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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S100A12 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for S100A12 1 / 2 / 3
3 probe-sets matching S100A12 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.19413 Expression variation in blood from EXPOLDB for S100A12
UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 Tissue specificity : Monocytes and lymphocytes
Orthologs for S100A12
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for S100A12 gene from 2 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
S100A121
--
S100 calcium binding protein A12
98.91(n) 97.83(a)
469835 XM_525220.2 XP_525220.2
cow (Bos taurus)
S100A121
--
S100 calcium binding protein A12 (calgranulin C)
76.81(n) 66.3(a)
282467 NM_174651.2 NP_777076.1
About this table Species with no ortholog for S100A12 ENSEMBL Gene Tree for S100A12 Paralogs for S100A12 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for S100A12 gene S100A8 2 S100P 2 S100A9 2
SNPs/Variants for S100A12 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for S100A12 (up to first 250kb)
Disorders & Mutations for S100A12
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 603112 10/17 Novoseek disease relationships for S100A12 gene (see all 17
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
moorens ulcer
84.82
3
9746433 (1), 9440166 (1), 10219252 (1)
kawasaki disease
58.45
8
15374807 (2), 12699958 (2), 15838637 (1), 17140160 (1)
inflammation
52.76
28
17675327 (3), 17208591 (2), 18164192 (2), 15077313 (2) (see all 19 )
rheumatoid arthritis
42.08
2
17223658 (1), 17140160 (1)
inflammatory bowel diseases
38.28
8
18050298 (2), 12740341 (2), 17675327 (2), 16259736 (1)
hypersensitivity contact
38.12
1
8902647 (1)
sepsis neonatal
38.03
1
19395960 (1)
chorioamnionitis
33.88
1
18238979 (2), 19395960 (1)
psoriasis
32.16
3
10844569 (1), 15099362 (1)
arthritis
30.10
5
12832707 (1), 18436720 (1), 12617572 (1), 15077313 (1) (see all 5 )
About this table 1 PharmGKB disease relationship for S100A12 gene About this table
Medical News for S100A12 (Possibly Related Articles in
Doctor's Guide )
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Publications for S100A12 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/126 PubMed articles for S100A12 gene (see all 126
): Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PubMed id 8985590) 1, 2, 3, 4 Wicki R.... Heizmann C.W. (1996) Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry. (PubMed id 8769108) 1, 3, 4 Ilg E.C.... Heizmann C.W. (1996) The three-dimensional structure of human S100A12. (PubMed id 11134923) 1, 3, 4 Moroz O.V.... Bronstein I.B. (2001) Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. (PubMed id 11522286) 1, 3, 4 Cole A.M.... Ganz T. (2001) Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PubMed id 8619876) 1, 3, 4 Marti T.... Gallin M.Y. (1996) Identification and characterization of a novel human neutrophil protein related to the S100 family. (PubMed id 7626002) 1, 3, 4 Guignard F.... Markert M. (1995) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Human CAAF1 gene -- molecular cloning, gene structure, and chromosome mapping. (PubMed id 8619860) 3, 4 Yamamura T.... Yamaguchi K. (1996) Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations. (PubMed id 15077313) 1, 3 Foell D....Roth J. (2004)
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Genome Databases showing S100A12
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing S100A12
(According to HUGE )
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--
Specialized Databases showing S100A12 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for S100A12 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for S100A12:
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