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Aliases for S100A12 Gene

Aliases for S100A12 Gene

  • S100 Calcium Binding Protein A12 2 3 5
  • Extracellular Newly Identified RAGE-Binding Protein 3 4
  • Migration Inhibitory Factor-Related Protein 6 3 4
  • Calcium-Binding Protein In Amniotic Fluid 1 3 4
  • Neutrophil S100 Protein 3 4
  • EN-RAGE 3 4
  • CAAF1 3 4
  • MRP-6 3 4
  • CGRP 3 4
  • CAGC 3 4
  • P6 3 4
  • S100 Calcium-Binding Protein A12 (Calgranulin C) 2
  • S100 Calcium Binding Protein A12 (Calgranulin C) 2
  • S100 Calcium-Binding Protein A12 4
  • Protein S100-A12 3
  • Calgranulin C 3
  • Calgranulin-C 4
  • Calcitermin 3
  • ENRAGE 3
  • MRP6 3

External Ids for S100A12 Gene

Previous GeneCards Identifiers for S100A12 Gene

  • GC01M151162
  • GC01M149128
  • GC01M150121
  • GC01M150562
  • GC01M150159
  • GC01M151612
  • GC01M124709

Summaries for S100A12 Gene

Entrez Gene Summary for S100A12 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for S100A12 Gene

S100A12 (S100 Calcium Binding Protein A12) is a Protein Coding gene. Diseases associated with S100A12 include Kawasaki Disease and Mooren's Ulcer. Among its related pathways are Activated TLR4 signalling and Advanced glycosylation endproduct receptor signaling. GO annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A9.

UniProtKB/Swiss-Prot for S100A12 Gene

  • S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Gene Wiki entry for S100A12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A12 Gene

Genomics for S100A12 Gene

Regulatory Elements for S100A12 Gene

Enhancers for S100A12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G153384 1.5 FANTOM5 Ensembl ENCODE 25.3 -13.1 -13052 7.8 PKNOX1 NFIB SIN3A RAD21 YY1 RCOR1 FOS EGR2 ZNF263 CEBPB S100A12 S100A9 S100A8 PGLYRP4 RNU6-160P S100A7L2 S100A4 ENSG00000224784 LAPTM4BP1
GH01G153363 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +9.7 9713 4.3 PKNOX1 SIN3A BMI1 RAD21 FOS RCOR1 IKZF2 CEBPB ELF1 ZNF217 S100A8 S100A12 ENSG00000224784 RNU6-160P S100A9
GH01G153552 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.5 -178.2 -178220 1.8 HDAC1 RB1 DMAP1 FEZF1 ZFHX2 ZNF766 ZNF366 ZBTB48 POLR2A PRDM10 S100A3 CHTOP S100A13 S100A16 S100A14 S100A1 INTS3 ENSG00000233222 ENSG00000243613 ILF2
GH01G153355 1.4 Ensembl ENCODE dbSUPER 7.7 +16.5 16519 7.4 TBP RB1 RAD21 YY1 ZNF143 CREM DEK ZNF654 SMARCC1 CEBPB ENSG00000224784 S100A8 RNU6-160P S100A16 S100A14 S100A12 PGLYRP4 LOC101928009 S100A9
GH01G153373 1.3 Ensembl ENCODE dbSUPER 7.7 +0.6 569 3.4 CTCF HDGF NFIB JUN CEBPG RAD21 ZNF664 GATA3 POLR2A EED PGLYRP4 RNU6-160P PGLYRP3 S100A12 S100A9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around S100A12 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A12 Gene

Chromosome:
1
Start:
153,373,706 bp from pter
End:
153,375,649 bp from pter
Size:
1,944 bases
Orientation:
Minus strand

Genomic View for S100A12 Gene

Genes around S100A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A12 Gene

Proteins for S100A12 Gene

  • Protein details for S100A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80511-S10AC_HUMAN
    Recommended name:
    Protein S100-A12
    Protein Accession:
    P80511
    Secondary Accessions:
    • P83219
    • Q5SY66
    • Q7M4R1

    Protein attributes for S100A12 Gene

    Size:
    92 amino acids
    Molecular mass:
    10575 Da
    Quaternary structure:
    • Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for S100A12 Gene

neXtProt entry for S100A12 Gene

Post-translational modifications for S100A12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for S100A12 (EN-RAGE/S100A12)

No data available for DME Specific Peptides for S100A12 Gene

Domains & Families for S100A12 Gene

Suggested Antigen Peptide Sequences for S100A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80511

UniProtKB/Swiss-Prot:

S10AC_HUMAN :
  • The hinge domain contributes significantly to its chemotactic properties.
  • Belongs to the S-100 family.
Domain:
  • The hinge domain contributes significantly to its chemotactic properties.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A12: view

Function for S100A12 Gene

Molecular function for S100A12 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A12,6.5kDa,expressed exclusively by granulocytes,independently from S100A8 and S100A9,identical to corneal associated antigen (COAG)
UniProtKB/Swiss-Prot Function:
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Gene Ontology (GO) - Molecular Function for S100A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 18443896
GO:0005509 calcium ion binding TAS 18443896
GO:0005515 protein binding IPI 19386136
GO:0008270 zinc ion binding TAS 11522286
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A12: view
genes like me logo Genes that share phenotypes with S100A12: view

Animal Model Products

miRNA for S100A12 Gene

miRTarBase miRNAs that target S100A12

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A12 Gene

Localization for S100A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A12 Gene

Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A12 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for S100A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 18443896
GO:0005634 nucleus IDA 15033494
GO:0005737 cytoplasm IDA,IEA 15033494
GO:0005829 cytosol TAS 18443896
GO:0005856 cytoskeleton TAS 18443896
genes like me logo Genes that share ontologies with S100A12: view

Pathways & Interactions for S100A12 Gene

SuperPathways for S100A12 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Cytosolic sensors of pathogen-associated DNA
3 Innate Immune System
4 Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
5 Advanced glycosylation endproduct receptor signaling
genes like me logo Genes that share pathways with S100A12: view

Gene Ontology (GO) - Biological Process for S100A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis TAS 18443896
GO:0006805 xenobiotic metabolic process IDA 11522286
GO:0006954 inflammatory response IEA,TAS --
GO:0030593 neutrophil chemotaxis TAS 18443896
GO:0031640 killing of cells of other organism IEA,IDA 11522286
genes like me logo Genes that share ontologies with S100A12: view

No data available for SIGNOR curated interactions for S100A12 Gene

Drugs & Compounds for S100A12 Gene

(8) Drugs for S100A12 Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlexanox Approved, Investigational Pharma Target, antagonist Inhibitor of TBK1 and IKKeta; antiallergic agent 3
Olopatadine Approved Pharma Target, antagonist 0
Patanase Approved April 2008 Pharma 0

(3) Additional Compounds for S100A12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A12: view

Transcripts for S100A12 Gene

mRNA/cDNA for S100A12 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A12 Gene

S100 calcium binding protein A12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A12 Gene

No ASD Table

Relevant External Links for S100A12 Gene

GeneLoc Exon Structure for
S100A12
ECgene alternative splicing isoforms for
S100A12

Expression for S100A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A12 Gene

This gene is overexpressed in Whole Blood (x48.4).

Protein differential expression in normal tissues from HIPED for S100A12 Gene

This gene is overexpressed in Saliva (12.3), Nasal epithelium (11.6), Neutrophil (9.2), Lavage (6.5), and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S100A12 Gene



Protein tissue co-expression partners for S100A12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A12 Gene:

S100A12

SOURCE GeneReport for Unigene cluster for S100A12 Gene:

Hs.19413

mRNA Expression by UniProt/SwissProt for S100A12 Gene:

P80511-S10AC_HUMAN
Tissue specificity: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohns disease, ulcerative colitis, and Kawasaki disease.

Evidence on tissue expression from TISSUES for S100A12 Gene

  • Blood(4.7)
  • Lung(4.6)
  • Liver(4.3)
  • Spleen(3.1)
  • Bone marrow(2.9)
  • Heart(2.5)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with S100A12: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A12 Gene

Orthologs for S100A12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A12 34 35
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia S100A12 34 35
  • 76.81 (n)
dog
(Canis familiaris)
Mammalia S100A12 34 35
  • 76.45 (n)
oppossum
(Monodelphis domestica)
Mammalia S100A12 35
  • 35 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5849 35
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
Species where no ortholog for S100A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A12 Gene

ENSEMBL:
Gene Tree for S100A12 (if available)
TreeFam:
Gene Tree for S100A12 (if available)

Paralogs for S100A12 Gene

(24) SIMAP similar genes for S100A12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A12: view

Variants for S100A12 Gene

Sequence variations from dbSNP and Humsavar for S100A12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000192113 -- 153,377,013(+) GGGAG(C/T)GGAGT upstream-variant-2KB
rs1000369413 -- 153,374,624(+) GGAAA(C/G)AAGGG intron-variant
rs1000474084 -- 153,375,690(+) GGCAA(-/T)TTATG upstream-variant-2KB
rs1002207009 -- 153,374,435(+) TTGCA(C/G)TGAGA intron-variant
rs1002703927 -- 153,376,591(+) CATGT(A/G)CCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for S100A12 Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958

Variation tolerance for S100A12 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A12 Gene

Disorders for S100A12 Gene

MalaCards: The human disease database

(8) MalaCards diseases for S100A12 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kawasaki disease
  • acute febrile mcls
mooren's ulcer
  • mooren ulcer
ulcerative colitis
  • left-sided ulcerative colitis
colitis
psoriatic arthritis
  • arthritis psoriatica
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A12

Genetic Association Database (GAD)
S100A12
Human Genome Epidemiology (HuGE) Navigator
S100A12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A12
genes like me logo Genes that share disorders with S100A12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A12 Gene

Publications for S100A12 Gene

  1. Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PMID: 8985590) Wicki R. … Heizmann C.W. (Cell Calcium 1996) 2 3 4 22 64
  2. Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. (PMID: 19386136) Moroz O.V. … Bronstein I.B. (BMC Biochem. 2009) 3 4 22 64
  3. The three-dimensional structure of human S100A12. (PMID: 11134923) Moroz O.V. … Bronstein I.B. (Acta Crystallogr. D 2001) 3 4 22 64
  4. Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. (PMID: 11522286) Cole A.M. … Ganz T. (FEBS Lett. 2001) 3 4 22 64
  5. Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PMID: 8619876) Marti T. … Gallin M.Y. (Biochem. Biophys. Res. Commun. 1996) 3 4 22 64

Products for S100A12 Gene

Sources for S100A12 Gene

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