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Aliases for S100A12 Gene

Aliases for S100A12 Gene

  • S100 Calcium Binding Protein A12 2 3 5
  • Extracellular Newly Identified RAGE-Binding Protein 3 4
  • S100 Calcium-Binding Protein A12 (Calgranulin C) 2 3
  • Migration Inhibitory Factor-Related Protein 6 3 4
  • Calcium-Binding Protein In Amniotic Fluid 1 3 4
  • Neutrophil S100 Protein 3 4
  • Calgranulin-C 3 4
  • EN-RAGE 3 4
  • CAAF1 3 4
  • MRP-6 3 4
  • CGRP 3 4
  • CAGC 3 4
  • P6 3 4
  • S100 Calcium Binding Protein A12 (Calgranulin C) 2
  • S100 Calcium-Binding Protein A12 4
  • Calgranulin C 3
  • Calcitermin 3
  • ENRAGE 3
  • MRP6 3

External Ids for S100A12 Gene

Previous GeneCards Identifiers for S100A12 Gene

  • GC01M151162
  • GC01M149128
  • GC01M150121
  • GC01M150562
  • GC01M150159
  • GC01M151612
  • GC01M124709

Summaries for S100A12 Gene

Entrez Gene Summary for S100A12 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for S100A12 Gene

S100A12 (S100 Calcium Binding Protein A12) is a Protein Coding gene. Diseases associated with S100A12 include kawasaki disease and mooren's ulcer. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A12 Gene

  • S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Gene Wiki entry for S100A12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A12 Gene

Genomics for S100A12 Gene

Regulatory Elements for S100A12 Gene

Enhancers for S100A12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around S100A12 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A12 Gene

Chromosome:
1
Start:
153,373,706 bp from pter
End:
153,375,649 bp from pter
Size:
1,944 bases
Orientation:
Minus strand

Genomic View for S100A12 Gene

Genes around S100A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A12 Gene

Proteins for S100A12 Gene

  • Protein details for S100A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80511-S10AC_HUMAN
    Recommended name:
    Protein S100-A12
    Protein Accession:
    P80511
    Secondary Accessions:
    • P83219
    • Q5SY66
    • Q7M4R1

    Protein attributes for S100A12 Gene

    Size:
    92 amino acids
    Molecular mass:
    10575 Da
    Quaternary structure:
    • Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for S100A12 Gene

neXtProt entry for S100A12 Gene

Proteomics data for S100A12 Gene at MOPED

Post-translational modifications for S100A12 Gene

No Post-translational modifications

Other Protein References for S100A12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for S100A12 (EN-RAGE/S100A12)

No data available for DME Specific Peptides for S100A12 Gene

Domains & Families for S100A12 Gene

Suggested Antigen Peptide Sequences for S100A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80511

UniProtKB/Swiss-Prot:

S10AC_HUMAN :
  • The hinge domain contributes significantly to its chemotactic properties.
  • Belongs to the S-100 family.
Domain:
  • The hinge domain contributes significantly to its chemotactic properties.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A12: view

Function for S100A12 Gene

Molecular function for S100A12 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A12,6.5kDa,expressed exclusively by granulocytes,independently from S100A8 and S100A9,identical to corneal associated antigen (COAG)
UniProtKB/Swiss-Prot Function:
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Gene Ontology (GO) - Molecular Function for S100A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,TAS 18443896
genes like me logo Genes that share ontologies with S100A12: view
genes like me logo Genes that share phenotypes with S100A12: view

Animal Model Products

miRNA for S100A12 Gene

miRTarBase miRNAs that target S100A12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A12 Gene

Localization for S100A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A12 Gene

Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A12 Gene COMPARTMENTS Subcellular localization image for S100A12 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for S100A12 Gene

Pathways & Interactions for S100A12 Gene

SuperPathways for S100A12 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Cytosolic sensors of pathogen-associated DNA
3 Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
4 Immune System
5 Advanced glycosylation endproduct receptor signaling
genes like me logo Genes that share pathways with S100A12: view

Interacting Proteins for S100A12 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357726%0d%0a9606.ENSP00000364217%0d%0a9606.ENSP00000356652%0d%0a
Selected Interacting proteins: P80511-S10AC_HUMAN ENSP00000357726 for S100A12 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for S100A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis TAS 18443896
GO:0006805 xenobiotic metabolic process IDA 11522286
GO:0030593 neutrophil chemotaxis TAS 18443896
GO:0031640 killing of cells of other organism IEA --
GO:0043406 positive regulation of MAP kinase activity TAS 18443896
genes like me logo Genes that share ontologies with S100A12: view

No data available for SIGNOR curated interactions for S100A12 Gene

Drugs & Compounds for S100A12 Gene

(6) Drugs for S100A12 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlexanox Approved, Investigational Pharma Target, antagonist 3
Olopatadine Approved Pharma Target, antagonist 0

(4) Additional Compounds for S100A12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A12: view

Transcripts for S100A12 Gene

mRNA/cDNA for S100A12 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A12 Gene

S100 calcium binding protein A12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A12 Gene

No ASD Table

Relevant External Links for S100A12 Gene

GeneLoc Exon Structure for
S100A12
ECgene alternative splicing isoforms for
S100A12

Expression for S100A12 Gene

mRNA expression in normal human tissues for S100A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A12 Gene

This gene is overexpressed in Whole Blood (x48.4).

Protein differential expression in normal tissues from HIPED for S100A12 Gene

This gene is overexpressed in Saliva (12.3), Nasal epithelium (11.6), Neutrophil (9.2), Lavage (6.5), and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S100A12 Gene



SOURCE GeneReport for Unigene cluster for S100A12 Gene Hs.19413

mRNA Expression by UniProt/SwissProt for S100A12 Gene

P80511-S10AC_HUMAN
Tissue specificity: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohns disease, ulcerative colitis, and Kawasaki disease.
genes like me logo Genes that share expression patterns with S100A12: view

Protein tissue co-expression partners for S100A12 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for S100A12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A12 35
  • 76.81 (n)
  • 66.3 (a)
S100A12 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A12 35
  • 76.45 (n)
  • 64.13 (a)
S100A12 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100A12 35
  • 98.91 (n)
  • 97.83 (a)
S100A12 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A12 36
  • 35 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5849 36
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for S100A12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A12 Gene

ENSEMBL:
Gene Tree for S100A12 (if available)
TreeFam:
Gene Tree for S100A12 (if available)

Paralogs for S100A12 Gene

(24) SIMAP similar genes for S100A12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A12: view

Variants for S100A12 Gene

Sequence variations from dbSNP and Humsavar for S100A12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4772 -- 153,373,787(-) CTCAA(C/T)GAGGG utr-variant-3-prime
rs2233862 -- 153,376,165(-) AGTTG(A/G)GAAAG upstream-variant-2KB
rs2233863 -- 153,374,050(-) CAACC(A/C/T)GAGCT intron-variant
rs2233864 -- 153,374,049(-) AACCC(A/C/G/T)AGCTC intron-variant
rs2233865 -- 153,373,662(-) GTTCC(C/T)AAACT downstream-variant-500B

Variation tolerance for S100A12 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A12 Gene

HapMap Linkage Disequilibrium report
S100A12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A12 Gene

Disorders for S100A12 Gene

MalaCards: The human disease database

(6) MalaCards diseases for S100A12 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kawasaki disease
  • acute febrile mcls
mooren's ulcer
  • mooren ulcer
ulcerative colitis
  • left-sided ulcerative colitis
psoriatic arthritis
  • arthritis psoriatica
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A12

Genetic Association Database (GAD)
S100A12
Human Genome Epidemiology (HuGE) Navigator
S100A12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A12
genes like me logo Genes that share disorders with S100A12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A12 Gene

Publications for S100A12 Gene

  1. Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PMID: 8985590) Wicki R. … Heizmann C.W. (Cell Calcium 1996) 2 3 4 23 67
  2. Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein. (PMID: 16864903) Kishimoto K. … Hasegawa K. (Mediators Inflamm. 2006) 3 23 25
  3. Serum S100A12 and temporomandibular joint magnetic resonance imaging in juvenile idiopathic arthritis Egyptian patients: a case control study. (PMID: 20437698) Abdul-Aziez O.A. … Ali Y. (Pak. J. Biol. Sci. 2010) 3 23
  4. Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo. (PMID: 20025991) Hoppmann S. … Pietzsch J. (Int. J. Biochem. Cell Biol. 2010) 3 23
  5. Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis. (PMID: 19284577) Chen Y.S. … Thomas R. (Arthritis Res. Ther. 2009) 3 23

Products for S100A12 Gene

Sources for S100A12 Gene

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