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S100A12 Gene

protein-coding   GIFtS: 56

GC01M151612
S100 calcium binding protein A12
(Previous names: S100 calcium-binding protein A12 (calgranulin C), S100 calcium binding protein A12 (calgranulin C) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CAAF1 1, 2, 3, 5
CAGC 1, 2, 3
CGRP 1, 2, 3, 5
Calgranulin-C 3
ENRAGE 1, 2
MRP6 1, 2
OTTHUMP00000015332 2
p6 1, 2, 3
Descriptions
Calcium-binding protein in amniotic fluid 1 3
Neutrophil S100 protein 3
S100 calcium binding protein A12 2
S100 calcium binding protein A12 (calgranulin C) 1
S100 calcium-binding protein A12 2, 3
S100 calcium-binding protein A12 (calgranulin C) 1, 2
calgranulin C 2
External Ids
HGNC: 104891
Entrez Gene: 62832
UniProtKB: P805113
Ensembl: ENSG000001632217
Search outside databases for aliases for S100A12 gene

Previous GC identifers: GC01M151162 GC01M149128 GC01M150121 GC01M150562 GC01M150159

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A12:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein is proposed to be involved in specific
calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal
components may modulate various neutrophil activities. [provided by RefSeq]

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Function: Calcitermin possesses antifungal activity against C.albicans and is also active against
E.coli and P.aeruginosa but not L.monocytogenes and S.aureus

Gene Wiki entry for S100A12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A12 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151612:     (about GC identifiers)

Start:
151,612,805 bp from pter
End:
151,614,699 bp from pter
Size:
1,895 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 (See protein sequence)
Recommended Name: Protein S100-A12  
Size: 92 amino acids; 10575 Da
Subunit: Homodimer
Mass spectrometry: Mass=10444; Method=Electrospray; Range=2-92; Source=PubMed:11522286;
Mass spectrometry: Mass=1688.9; Method=MALDI; Range=78-92; Source=PubMed:11522286;
PDB structures from and Proteopedia :
1E8A (3D)    1GQM (3D)    1ODB (3D)    
Secondary accessions: P83219 Q5SY66 Q7M4R1

REFSEQ proteins: NP_005612.1  

ENSEMBL proteins: 
ENSP00000357726 ENSP00000357725 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (S100A12)
Human Recombinant Proteins from Abnova (S100A12)
              OriGene Purified Recombinant Human Protein: S100A12 

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005626 insoluble fraction TAS7626002
GO:0005634 nucleus IDA18029348
GO:0005730 nucleolus IDA18029348
GO:0005737 cytoplasm IDA18029348
GO:0005829 cytosol TAS7626002
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Antibodies for S100A12: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for S100A12
R&D Systems Antibodies for S100A12 (EN-RAGE/S100A12)
Antibodies from Abcam (S100A12), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (S100A12)
Novus Biologicals Antibodies for S100A12

Assays for S100A12: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5/6 InterPro domains/families (see all 6 ):
 IPR018247 EF_HAND_1
 IPR011992 EF-Hand_type
 IPR018248 EF_hand
 IPR013787 S100_Ca_bd_sub
 IPR018249 EF_HAND_2


   GeneDecks  S100A12 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P80511

ProtoNet protein and cluster: P80511

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Similarity: Belongs to the S-101 family
Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (S100A12)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005621

              Applied Biosystems Silencer® siRNAs for S100A12

              Sigma-Aldrich siRNA for S100A12  
                     Sigma-Aldrich shRNA for S100A12  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for S100A12
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005621
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005621
                                 untagged cDNA clone in CMV expression vector: NM_005621 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005621

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Function: Calcitermin possesses antifungal activity against C.albicans and is also active against
E.coli and P.aeruginosa but not L.monocytogenes and S.aureus

Genatlas biochemistry entry for S100A12:
S100 calcium binding protein A12,6.5kDa,expressed exclusively by granulocytes,independently from
S100A8 and S100A9,identical to corneal associated antigen (COAG)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005509 calcium ion binding TAS7626002
GO:0008270 zinc ion binding TAS11522286
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  S100A12 


5 Interacting proteins for S100A12 (ENSP000003577263) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
CACYBPENSP000003566523STRING (score=.894)
ABCC11ENSP000003490173STRING (score=.744)
ABCC8ENSP000003039603STRING (score=.744)
HRASENSP000003733823STRING (score=.733)
LY96ENSP000002848183STRING (score=.718)
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4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006805 xenobiotic metabolic process IDA11522286
GO:0006954 inflammatory response TAS8619876
GO:0042742 defense response to bacterium IEA--
GO:0050832 defense response to fungus IDA11522286
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A12
6 Novoseek chemical compound relationships for S100A12 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 17.29 21 15355353 (4), 11856825 (3), 8603881 (2), 12740341 (1) (see all 6)
oligonucleotide 2.13 2 10219252 (1)
polyacrylamide 0.00 1 8934661 (1)
glucose 0.00 2 1573849 (1), 15531492 (1)
copper 0.00 4 12645006 (2), 15251957 (1)
zinc 0.00 2 10569784 (1), 12645006 (1)
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2 PharmGKB drug compound relationships for S100A12 gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
mercaptopurinePD  FA  GN  12704389
methotrexatePD  FA  GN  12704389
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (S100A12)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005621

              Sigma-Aldrich siRNA for S100A12  
                     Sigma-Aldrich shRNA for S100A12  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005621  

REFSEQ mRNAs for S100A12 gene: 

NM_005621.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005621  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005621
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005621
                                 untagged cDNA clone in CMV expression vector: NM_005621 

Additional cDNA sequence: 

BC070294.1 D49549.1 D83664.1 X97859.1 

2 DOTS entries:

DT.412396  DT.100726392 

24/43 AceView cDNA sequences (see all 43 ):

X97859 D83664 BX092856 AA321239 NM_005621 AU100319 AW468479 AA313230 
AA707079 AI161013 AJ706429 BC070294 AI718758 AI735194 AW952195 AJ713981 
AJ706621 AJ706358 AI365228 AW016082 AA984879 AA700005 AJ706518 AI056983 

highest scoring ESTs for S100A12:

D83664 AA203475 AA313230 AA321239 AJ706358 AJ713981 AU100319 AV715719 AV715975 AV758762 

Unigene Cluster for S100A12:

S100 calcium binding protein A12
Hs.19413  [show with all ESTs]
Unigene Representative Sequence: AV758762


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000368737  ENST00000368736  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A12 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for S100A12

1 / 2 / 3

3 probe-sets matching S100A12 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38879_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D83664 1.00 1.00 1.00 1

205863_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005621 0.60 1.00 0.82 1

205863_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  S100A12 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.19413

Expression variation in blood from EXPOLDB for S100A12

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Tissue specificity: Monocytes and lymphocytes

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for S100A12 gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
S100A121   -- S100 calcium binding protein A12 98.91(n)
97.83(a)
469835  XM_525220.2  XP_525220.2 
cow
(Bos taurus)
S100A121   -- S100 calcium binding protein A12 (calgranulin C) 76.81(n)
66.3(a)
282467  NM_174651.2  NP_777076.1 
About this table        Species with no ortholog for S100A12

ENSEMBL Gene Tree for S100A12
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for S100A12 gene
S100A82  S100P2  S100A92  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/19 NCBI SNPs in S100A12 are shown (see all 19 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs47721,2
A,C,F,H151612887(-) CTCAAT/CGAGGG 1 -- ut315Minor allele frequency- C:0.07MN EU EA WA 604
rs30064761,2
A,C,F,H151615734(+) ctctcC/Agatcc 1 -- ng31 tfbs37Minor allele frequency- A:0.12EU EA WA NA 556
--
rs30148821,2
A,C151612406(+) actacA/Ggcctc 1 -- ng510--------
rs22338621,2
H151615265(-) AGTTGG/AGAAAG 1 -- ng314Minor allele frequency- A:0.00EU EA WA 414
--
rs29161911,2
A151612535(-) GAGAGA/GATAGA 1 -- ng510--------
rs43236541,2
H151614957(+) TTTTAG/ACCCTG 1 -- ng314Minor allele frequency- A:0.00EU EA WA 420
--
rs30148841,2
A,C151614117(+) cttttG/Tttgtt 1 -- int1 trp30--------
--
rs30148831,2
C151614084(+) AAATGG/TTCCAT 1 -- int10--------
--
rs66897671,2
--151615815(+) cccagC/Gaggac 1 -- ng310--------
--
rs355325391,2
--151615739(+) GATCC-/CATGTG 1 -- ng310--------
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HapMap Linkage Disequilibrium images for S100A12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603112

10/17 Novoseek disease relationships for S100A12 gene (see all 17 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
moorens ulcer 84.82 3 9746433 (1), 9440166 (1), 10219252 (1)
kawasaki disease 58.45 8 15374807 (2), 12699958 (2), 15838637 (1), 17140160 (1)
inflammation 52.76 28 17675327 (3), 17208591 (2), 18164192 (2), 15077313 (2) (see all 19)
rheumatoid arthritis 42.08 2 17223658 (1), 17140160 (1)
inflammatory bowel diseases 38.28 8 18050298 (2), 12740341 (2), 17675327 (2), 16259736 (1)
hypersensitivity contact 38.12 1 8902647 (1)
sepsis neonatal 38.03 1 19395960 (1)
chorioamnionitis 33.88 1 18238979 (2), 19395960 (1)
psoriasis 32.16 3 10844569 (1), 15099362 (1)
arthritis 30.10 5 12832707 (1), 18436720 (1), 12617572 (1), 15077313 (1) (see all 5)
About this table

1 PharmGKB disease relationship for S100A12 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/126 PubMed articles for S100A12 gene (see all 126 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6283 HGNC: 10489 AceView: S100A12 Ensembl:ENSG00000163221 euGenes: HUgn6283
ECgene: S100A12 H-InvDB: S100A12
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for S100A12:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Predesigned and custom siRNAs for S100A12 Antibodies for S100A12
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 Lentivirus-delivered shRNAs for S100A12 Browse small molecules at Sigma-Aldrich
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 Search Tocris compounds for S100A12




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 Antibodies for S100A12

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