S100A12 Gene
protein-coding GIFtS: 56
GCID: GC01M153346
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|
S100 calcium binding protein A12(Previous names: S100 calcium-binding protein A12 (calgranulin C), S100...)
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Aliases
for S100A12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| S100 Calcium Binding Protein A121 2 | | Migration Inhibitory Factor-Related Protein 62 3 | | CAAF11 2 3 5 | | Neutrophil S100 Protein2 3 | | CGRP1 2 3 5 | | EN-RAGE2 3 | | CAGC1 2 3 | | MRP-62 3 | | P61 | | S100 Calcium Binding Protein A12 (Calgranulin C)1 | | ENRAGE1 2 | | Calgranulin C2 | | MRP61 2 | | Calgranulin-C3 | | S100 Calcium-Binding Protein A12 (Calgranulin C)1 2 | | Protein S100-A122 | | Calcium-Binding Protein In Amniotic Fluid 12 3 | | Calgranulin-C3 | | Extracellular Newly Identified RAGE-Binding Protein2 3 | | S100 Calcium-Binding Protein A123 |
Export aliases for S100A12 gene to outside databasesPrevious GC identifers: GC01M151162 GC01M149128 GC01M150121 GC01M150562 GC01M150159 GC01M151612 GC01M124709 |
Summaries
for S100A12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for S100A12:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-bindingmotifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in theregulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include atleast 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved inspecific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components maymodulate various neutrophil activities. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511Function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation ofinflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotionof cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or adanger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor foradvanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathwaysleading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Actsas a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generateschemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibitthe activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possessesfilariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is alsoactive against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus
Gene Wiki entry for S100A12
|
Genomic Views
for S100A12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the S100A12 gene promoter:
RFX1 AML1a Tal-1 AP-1 MyoD Lmo2 LCR-F1 E47 GATA-1 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for S100A12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21S100A12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153346: view genomic region
(about GC identifiers)
Start:
|
153,346,184 bp from pter |
End:
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153,348,125 bp from pter |
Size:
|
1,942 bases |
Orientation:
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minus strand |
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Proteins
for S100A12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 (See
protein sequence)Recommended Name: Protein S100-A12 Size: 92 amino acids; 10575 Da
Subunit: Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts withAGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a calcium-dependent manner
Subcellular location: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated fromthe cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via amicrotubule-mediated, alternative pathway
Mass spectrometry: Mass=10444; Method=Electrospray; Range=2-92; Source=PubMed:11522286;
Mass spectrometry: Mass=1688.9; Method=MALDI; Range=78-92; Source=PubMed:11522286;
6/7 PDB 3D structures from  and Proteopedia  for S100A12 (see all 7):1E8A (3D)
1GQM (3D)
1ODB (3D)
2WC8 (3D)
2WCB (3D)
2WCE (3D)
Secondary accessions: P83219 Q5SY66 Q7M4R1Explore the universe of human proteins at neXtProt for S100A12: NX_P80511
S100A12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005612.1
ENSEMBL proteins: ENSP00000357726 Reactome Protein details: P80511
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
S100A12 for ontologies About GeneDecksing
S100A12 Antibody Products:
Assay Products for S100A12: |
Protein
Domains /
Families
for S100A12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
S100A12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P80511ProtoNet protein and cluster: P80511 1 Blocks protein family: IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511Domain: The hinge domain contributes significantly to its chemotactic propertiesSimilarity: Belongs to the S-101 familySimilarity: Contains 2 EF-hand domains |
Function
for S100A12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511Function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation ofinflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotionof cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or adanger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor foradvanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathwaysleading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Actsas a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generateschemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibitthe activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possessesfilariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is alsoactive against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus Genatlas biochemistry entry for S100A12:S100 calcium binding protein A12,6.5kDa,expressed exclusively by granulocytes,independently from S100A8 andS100A9,identical to corneal associated antigen (COAG)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A12
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: S100A12 (NM_005621) | |  | Sino Biological Human cDNA Clone for S100A12 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100A12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A12 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
S100A12 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for S100A12:
|
Pathways & Interactions
for S100A12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Advanced glycosylation endproduct receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for S100A12
S100A12 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A12
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for S100A12 (P805113 ENSP000003577264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
S100A12 for ontologies About GeneDecksing
|
Drugs & Compounds
for S100A12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
S100A12 for compounds About GeneDecksing
 Browse Tocris compounds for S100A12
2 DrugBank Compounds for S100A12 About this table
10 Novoseek chemical compound relationships for S100A12 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| amlexanox |
73.2 |
3 |
16864903 (1), 11944917 (1) |
| olopatadine |
59.9 |
8 |
16864903 (5), 11944917 (1) |
| ivig |
41.2 |
4 |
15374807 (3), 19680167 (1) |
| capsaicin |
21.6 |
4 |
18236014 (2), 7560753 (1), 16259736 (1) |
| calcium |
18.6 |
28 |
19386136 (4), 15355353 (4), 11856825 (3), 8603881 (2) (see all 8) |
| copper |
7.36 |
4 |
12645006 (2), 15251957 (1) |
| zinc |
2.8 |
9 |
19386136 (5), 10569784 (1), 12645006 (1) |
| polyacrylamide |
0 |
1 |
8934661 (1) |
| oligonucleotide |
0 |
2 |
10219252 (1) |
| glucose |
0 |
11 |
19833897 (3), 1573849 (1), 15531492 (1) |
Search CenterWatch for drugs/clinical trials and news about S100A12 / S10AC
|
Transcripts
for S100A12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for S100A12 gene: NM_005621.1 Unigene Cluster for S100A12: S100 calcium binding protein A12 Hs.19413 [show with all ESTs]Unigene Representative Sequence: AV7587621 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368737(uc001fbr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A12
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: S100A12 (NM_005621) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100A12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A12 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100A12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat S100A12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100A12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A12 |
Additional cDNA sequence: BC070294.1 D49549.1 D83664.1 X97859.1 2 DOTS entries: DT.412396 DT.100726392 24/43 AceView cDNA sequences (see all 43): D83664 NM_005621 AA321239 BX092856 X97859 AA707079 AW468479 AU100319 AA313230 AI161013 BC070294 AW952195 AJ706429 AI718758 AI735194 AA700005 AJ706621 AA984879 AI365228 AW016082 AJ713981 AI056983 AJ706518 AJ706358
GeneLoc Exon Structure
|
Expression
for S100A12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| S100A12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See S100A12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100A12
SOURCE GeneReport for Unigene cluster: Hs.19413
UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511Tissue specificity: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed byeosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrationsin the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriaticarthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease
SABiosciences Expression via Pathway-Focused PCR Arrays including S100A12: | cAMP / Ca2+ Signaling PathwayFinder in human mouse rat | | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100A12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat S100A12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100A12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A12 |
Orthologs
for S100A12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for S100A12 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for S100A12 (if available)
TreeFam Gene Tree for S100A12 (if available) |
Paralogs
for S100A12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for S100A12 gene
- S100A112 S100A62 S100A12 S100A82 S100A42 S100B2 S100A32 S100A102
- S100Z2 S100A52 S100P2 S100A22 S100A92
18/24 SIMAP similar genes for S100A12 using alignment to 1 protein entry: S10AC_HUMAN(see all similar genes):S100B HRNR S100A4 S100A9 S100A13 S100A5
S100Z S100A11 S100A6 FLG2 S100A16 S100P
S100A2 FLG S100A7L3 S100A1 S100A14 S100A10
S100A12 for paralogs About GeneDecksing
|
Genomic Variants
for S100A12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for S100A12 (153346184 - 153348125 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for S100A12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100A12 |
|
Disorders
/ Diseases
for S100A12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
S100A12 for disorders About GeneDecksing
OMIM gene information: 603112
OMIM disorders: --
20/44  diseases for S100A12 (see all 44): About MalaCardsmooren's ulcer cluster headache inflammatory bowel disease irritable bowel syndrome
juvenile rheumatoid arthritis rheumatoid arthritis funisitis chorioamnionitis
kawasaki disease reactive arthritis headache dysautonomia
psoriatic arthritis onchocerciasis arthritis ulcerative colitis
hirschsprung's disease cystic fibrosis diabetes mellitus keratitis
3 diseases from the University of Copenhagen DISEASES database for S100A12:Mooren's ulcer Kawasaki disease Inflammatory bowel disease 10/17 Novoseek disease relationships for S100A12 gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| moorens ulcer |
83.6 |
3 |
9746433 (1), 9440166 (1), 10219252 (1) |
| kawasaki disease |
59.3 |
8 |
15374807 (2), 12699958 (2), 15838637 (1), 17140160 (1) |
| inflammation |
55.6 |
32 |
17675327 (3), 17208591 (2), 18164192 (2), 20437698 (2) (see all 22) |
| rheumatoid arthritis |
44.5 |
4 |
19284577 (1), 20100792 (1), 17223658 (1), 17140160 (1) |
| arthritis |
39.9 |
10 |
20437698 (3), 12832707 (1), 12617572 (1), 19035478 (1) (see all 6) |
| hypersensitivity contact |
34.9 |
1 |
8902647 (1) |
| sepsis neonatal |
34.6 |
1 |
19395960 (1) |
| inflammatory bowel diseases |
34.5 |
8 |
18050298 (2), 12740341 (2), 17675327 (2), 16259736 (1) |
| psoriasis |
33.8 |
3 |
10844569 (1), 15099362 (1) |
| chorioamnionitis |
30.6 |
1 |
18238979 (2), 19395960 (1) |
Human Genome Epidemiology (HuGE) Navigator: S100A12 (2 documents)
Export disorders for S100A12 gene to outside databases
|
Publications
for S100A12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for S100A12 gene, integrated from 9 sources (see all 164):
(articles sorted by number of sources associating them with S100A12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PubMed id 8985590)1, 2, 3, 9 Wicki R.... Heizmann C.W. (1996)
- Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry. (PubMed id 8769108)1, 2, 9 Ilg E.C.... Heizmann C.W. (1996)
- Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein. (PubMed id 16864903)1, 7, 9 Kishimoto K....Hasegawa K. (2006)
- Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. (PubMed id 19386136)1, 2, 9 Moroz O.V....Bronstein I.B. (2009)
- The three-dimensional structure of human S100A12. (PubMed id 11134923)1, 2, 9 Moroz O.V.... Bronstein I.B. (2001)
- Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. (PubMed id 11522286)1, 2, 9 Cole A.M.... Ganz T. (2001)
- Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PubMed id 8619876)1, 2, 9 Marti T.... Gallin M.Y. (1996)
- Identification and characterization of a novel human neutrophil protein related to the S100 family. (PubMed id 7626002)1, 2, 9 Guignard F.... Markert M. (1995)
- CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. (PubMed id 12042313)1, 2, 9 Filipek A....Kuznicki J. (2002)
- The crystal structures of human S100A12 in apo form a nd in complex with zinc: new insights into S100A12 oligomerisation. (PubMed id 19501594)1, 2 Moroz O.V....Bronstein I.B. (2009)
|
External Searches for S100A12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing S100A12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing S100A12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing S100A12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for S100A12 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for S100A12 gene:
Search GeneIP for patents involving S100A12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for S100A12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for S100A12 | | OriGene shRNA RFP for S100A12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for S100A12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100A12 | | | OriGene Protein Over-expression Lysate for S100A12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for S100A12 | | OriGene 3'-UTR Clone for S100A12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for S100A12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for S100A12 | | OriGene Custom Protein Services for S100A12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat S100A12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100A12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat S100A12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100A12 |
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| | | | Search Tocris compounds for S100A12 |
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 | | | S100A12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for S100A12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A12 |
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