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S100A12 Gene

protein-coding   GIFtS: 59
GCID: GC01M153346

S100 Calcium Binding Protein A12

(Previous names: S100 calcium-binding protein A12 (calgranulin C), S100 calcium...)
  See S100A12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A121 2     MRP-62 3
CAAF12 3 5     p62 3
CGRP2 3 5     S100 Calcium Binding Protein A12 (Calgranulin C)1
S100 Calcium-Binding Protein A12 (Calgranulin C)1 2     ENRAGE2
Calcium-Binding Protein In Amniotic Fluid 12 3     MRP62
Extracellular Newly Identified RAGE-Binding Protein2 3     Calgranulin C2
Migration Inhibitory Factor-Related Protein 62 3     calgranulin-C2
Neutrophil S100 Protein2 3     Protein S100-A122
CAGC2 3     Calgranulin-C3
EN-RAGE2 3     S100 Calcium-Binding Protein A123

External Ids:    HGNC: 104891   Entrez Gene: 62832   Ensembl: ENSG000001632217   OMIM: 6031125   UniProtKB: P805113   

Export aliases for S100A12 gene to outside databases

Previous GC identifers: GC01M151162 GC01M149128 GC01M150121 GC01M150562 GC01M150159 GC01M151612 GC01M124709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A12 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be
involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal
components may modulate various neutrophil activities. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100A12 Gene:
S100A12 (S100 calcium binding protein A12) is a protein-coding gene. Diseases associated with S100A12 include funisitis, and juvenile rheumatoid arthritis. GO annotations related to this gene include RAGE receptor binding and calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation
of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes,
promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an
alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding
to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B
signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion
molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell
degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte
recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and
MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin
possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not
L.monocytogenes and S.aureus

Gene Wiki entry for S100A12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A12 gene promoter:
         RFX1   AML1a   Tal-1   AP-1   MyoD   Lmo2   LCR-F1   E47   GATA-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A12 promoter sequence
   Search Chromatin IP Primers for S100A12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153346:  view genomic region     (about GC identifiers)

Start:
153,346,184 bp from pter      End:
153,348,125 bp from pter
Size:
1,942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511 (See protein sequence)
Recommended Name: Protein S100-A12  
Size: 92 amino acids; 10575 Da
Subunit: Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts
with AGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a
calcium-dependent manner
Mass spectrometry: Mass=10444; Method=Electrospray; Range=2-92; Source=PubMed:11522286;
Mass spectrometry: Mass=1688.9; Method=MALDI; Range=78-92; Source=PubMed:11522286;
Selected PDB 3D structures from and Proteopedia for S100A12 (see all 7):
1E8A (3D)        1GQM (3D)        1ODB (3D)        2WC8 (3D)        2WCB (3D)        2WCE (3D)    
Secondary accessions: P83219 Q5SY66 Q7M4R1

Explore the universe of human proteins at neXtProt for S100A12: NX_P80511

Explore proteomics data for S100A12 at MOPED


See S100A12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005612.1  
ENSEMBL proteins: 
 ENSP00000357726  
Reactome Protein details: P80511

S100A12 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for S100A12
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Novus Biologicals S100A12 Proteins
Novus Biologicals S100A12 Lysates
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Cloud-Clone Corp. Proteins for S100A12

 
Search eBioscience for Proteins for S100A12 

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LSBio Antibodies in human, mouse, rat for S100A12

S100A12 Assay Products:

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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for S100A12
Cloud-Clone Corp. CLIAs for S100A12
Search eBioscience for ELISAs for S100A12 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
EFHAND: EF-hand domain containing
S100: S100 calcium binding proteins

5 InterPro protein domains:
 IPR011992 EF-hand-dom_pair
 IPR002048 EF_hand_dom
 IPR013787 S100_Ca-bd_sub
 IPR028442 S100A12
 IPR001751 S100/CaBP-9k_CS

Graphical View of Domain Structure for InterPro Entry P80511

ProtoNet protein and cluster: P80511

1 Blocks protein domain: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Domain: The hinge domain contributes significantly to its chemotactic properties
Similarity: Belongs to the S-101 family
Similarity: Contains 2 EF-hand domains


Find genes that share domains with S100A12           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: S10AC_HUMAN, P80511
Function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation
of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes,
promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an
alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding
to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B
signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion
molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell
degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte
recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and
MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin
possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not
L.monocytogenes and S.aureus

     Genatlas biochemistry entry for S100A12:
S100 calcium binding protein A12,6.5kDa,expressed exclusively by granulocytes,independently from S100A8 and
S100A9,identical to corneal associated antigen (COAG)

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005507copper ion binding TAS18443896
GO:0005509calcium ion binding TAS18443896
GO:0005515protein binding IPI19386136
GO:0008270zinc ion binding TAS11522286
GO:0050786RAGE receptor binding TAS18443896
     
Find genes that share ontologies with S100A12           About GenesLikeMe


Phenotypes:
     4 GenomeRNAi human phenotypes for S100A12:
 Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased G1 DNA content  Increased cell death in breast 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S100A12
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for S100A12
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S100A12

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Predesigned siRNA for gene silencing in human, mouse, rat S100A12

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Sino Biological Human cDNA Clone for S100A12
DNA2.0 Custom Codon Optimized Gene Synthesis Service for S100A12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A12

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A12


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S10AC_HUMAN, P80511: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.
Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated
from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a
microtubule-mediated, alternative pathway
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
cytosol5
extracellular5
nucleus5
plasma membrane5

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS18443896
GO:0005634nucleus IDA15033494
GO:0005737cytoplasm IDA15033494
GO:0005829cytosol TAS18443896
GO:0005856cytoskeleton TAS18443896

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for S100A12 About    
See pathways by source

SuperPathContained pathways About
1Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor 9 (TLR9) Cascade0.93
MyD88 dependent cascade initiated on endosome0.69
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
MyD88-independent cascade0.69
Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
Toll Like Receptor 3 (TLR3) Cascade0.69
2Cytosolic sensors of pathogen-associated DNA
RIP-mediated NFkB activation via ZBP10.81
TAK1 activates NFkB by phosphorylation and activation of IKKs complex0.52
ZBP1(DAI) mediated induction of type I IFNs0.81
Cytosolic sensors of pathogen-associated DNA0.38
TRAF6 mediated NF-kB activation0.55
DEx/H-box helicases activate type I IFN and inflammatory cytokines production0.00
3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
4Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling


Find genes that share SuperPaths with S100A12           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



5 Reactome Pathways for S100A12
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Advanced glycosylation endproduct receptor signaling
RIP-mediated NFkB activation via ZBP1
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TRAF6 mediated NF-kB activation


    Pathway & Disease-focused RT2 Profiler PCR Arrays including S100A12: 
          cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for S100A12

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

Selected Interacting proteins for S100A12 (P805113 ENSP000003577264) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
AGERQ151093, ENSP000003642174I2D: score=3 STRING: ENSP00000364217
ENSG00000206320Q151093I2D: score=3 
ENSG00000229058Q151093I2D: score=3 
ENSG00000230514Q151093I2D: score=3 
ENSG00000231268Q151093I2D: score=3 
About this table

Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002548monocyte chemotaxis TAS18443896
GO:0006805xenobiotic metabolic process IDA11522286
GO:0006954inflammatory response IEA--
GO:0030593neutrophil chemotaxis TAS18443896
GO:0031640killing of cells of other organism IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for S100A12 (S10AC)

2 DrugBank Compounds for S100A12    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
AmlexanoxAmlexanox [USAN:INN:JAN] (see all 3)68302-57-8targetantagonist16864903 11944917 10051426
Olopatadine-- 113806-05-6targetantagonist16864903 11944917

10 Novoseek inferred chemical compound relationships for S100A12 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
amlexanox 73.2 3 16864903 (1), 11944917 (1)
olopatadine 59.9 8 16864903 (5), 11944917 (1)
ivig 41.2 4 15374807 (3), 19680167 (1)
capsaicin 21.6 4 18236014 (2), 7560753 (1), 16259736 (1)
calcium 18.6 28 19386136 (4), 15355353 (4), 11856825 (3), 8603881 (2) (see all 8)
copper 7.36 4 12645006 (2), 15251957 (1)
zinc 2.8 9 19386136 (5), 10569784 (1), 12645006 (1)
polyacrylamide 0 1 8934661 (1)
oligonucleotide 0 2 10219252 (1)
glucose 0 11 19833897 (3), 1573849 (1), 15531492 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for S100A12 gene: 
NM_005621.1  

Unigene Cluster for S100A12:

S100 calcium binding protein A12
Hs.19413  [show with all ESTs]
Unigene Representative Sequence: AV758762
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000368737(uc001fbr.1)
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GenScript: all cDNA clones in your preferred vector: S100A12 (NM_005621)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for S100A12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A12
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  QuantiFast Probe-based Assays in human, mouse, rat S100A12

Additional mRNA sequence: 

BC070294.1 D49549.1 D83664.1 X97859.1 

2 DOTS entries:

DT.412396  DT.100726392 

Selected AceView cDNA sequences (see all 43):

NM_005621 AA313230 X97859 AW468479 AA707079 AA321239 AU100319 BX092856 
D83664 AJ706429 AI735194 AW952195 BC070294 AI718758 AI161013 AJ706358 
AJ713981 AA984879 AA700005 AI365228 AW016082 AJ706518 AI056983 AJ706621 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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S100A12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
S100A12 Expression
About this image


S100A12 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Epithelial Cells
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Blood (Hematopoietic System)
         Monocytes Peripheral Blood
 
 Eye (Sensory Organs)
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
 
 Spleen (Hematopoietic System)
S100A12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

S100A12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.19413

UniProtKB/Swiss-Prot: S10AC_HUMAN, P80511
Tissue specificity: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by
eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high
concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid
arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease

    Pathway & Disease-focused RT2 Profiler PCR Arrays including S100A12: 
          cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for S100A12
OriGene qSTAR qPCR primer pairs in human, mouse for S100A12
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat S100A12
QuantiTect SYBR Green Assays in human, mouse, rat S100A12
QuantiFast Probe-based Assays in human, mouse, rat S100A12
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A12

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for S100A12 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Protein MRP-126
33(a)
1 → many
25(734441-740904)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
44(a)
39(a)
many ↔ many
many ↔ many
GL344021.1(33199-34917)
GL344021.1(46006-48364)
        Species with no ortholog for S100A12

ENSEMBL Gene Tree for S100A12 (if available)
TreeFam Gene Tree for S100A12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for S100A12 gene
S100A112  S100A62  S100A12  S100B2  S100A42  S100A32  S100A102  S100Z2  
S100P2  S100A52  S100A22  S100A92  
Selected SIMAP similar genes for S100A12 using alignment to 1 protein entry:     S10AC_HUMAN(see all similar genes):
S100B    HRNR    S100A4    S100A9    S100A13    S100A5
S100Z    S100A11    S100A6    FLG2    S100A16    S100P
FLG    S100A2    S100A7L3    S100A1    S100A14    S100A10

Find genes that share paralogs with S100A12           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for S100A12 (see all 93)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1119973801,2
F--153345745(+) GGAATG/ACAATA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs30148821,2
C,F,A--153345782(+) actacG/Agcctc 1 -- ds50017Minor allele frequency- A:0.32NA WA CSA 129
rs1441518671,2
C--153345816(+) TCTCGA/CCCCAG 1 -- ds50010--------
rs1451410871,2
C--153345849(+) GGCACA/GTGCCA 1 -- ds50010--------
rs29161911,2
C,F,A--153345911(-) GAGAGA/GATAGA 1 -- ds50016Minor allele frequency- G:0.09NA WA CSA EA 248
rs22338671,2
--153345993(-) cactcA/TctcaA 1 -- ds50010--------
rs22338661,2
F--153346065(-) ATTTGC/TTCATT 1 -- ds50010--------
rs22338651,2
F--153346138(-) GTTCCC/TAAACT 1 -- ds50011Minor allele frequency- T:0.02WA 118
rs1816993011,2
--153346145(+) GAACCA/GCAGGC 1 -- ds50010--------
rs1859315411,2
--153346148(+) CCGCAA/GGCATG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for S100A12 (153346184 - 153348125 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for S100A12: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing S100A12
DNA2.0 Custom Variant and Variant Library Synthesis for S100A12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603112    OMIM disorders: --

4 diseases for S100A12:    
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funisitis    juvenile rheumatoid arthritis    psoriatic arthritis    rheumatoid arthritis

3 diseases from the University of Copenhagen DISEASES database for S100A12:
Mooren's ulcer     Kawasaki disease     Inflammatory bowel disease

Find genes that share disorders with S100A12           About GenesLikeMe

Selected Novoseek inferred disease relationships for S100A12 gene (see all 17)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
moorens ulcer 83.6 3 9746433 (1), 9440166 (1), 10219252 (1)
kawasaki disease 59.3 8 15374807 (2), 12699958 (2), 15838637 (1), 17140160 (1)
inflammation 55.6 32 17675327 (3), 17208591 (2), 18164192 (2), 20437698 (2) (see all 22)
rheumatoid arthritis 44.5 4 19284577 (1), 20100792 (1), 17223658 (1), 17140160 (1)
arthritis 39.9 10 20437698 (3), 12832707 (1), 12617572 (1), 19035478 (1) (see all 6)
hypersensitivity contact 34.9 1 8902647 (1)
sepsis neonatal 34.6 1 19395960 (1)
inflammatory bowel diseases 34.5 8 18050298 (2), 12740341 (2), 17675327 (2), 16259736 (1)
psoriasis 33.8 3 10844569 (1), 15099362 (1)
chorioamnionitis 30.6 1 18238979 (2), 19395960 (1)

Genetic Association Database (GAD): S100A12
Human Genome Epidemiology (HuGE) Navigator: S100A12 (2 documents)

Export disorders for S100A12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for S100A12 gene, integrated from 10 sources (see all 168):
(articles sorted by number of sources associating them with S100A12)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PubMed id 8985590)1, 2, 3, 9 Wicki R.... Heizmann C.W. (Cell Calcium 1996)
  2. Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry. (PubMed id 8769108)1, 2, 9 Ilg E.C.... Heizmann C.W. (Biochem. Biophys. Res. Commun. 1996)
  3. Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein. (PubMed id 16864903)1, 7, 9 Kishimoto K....Hasegawa K. (Mediators Inflamm. 2006)
  4. Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. (PubMed id 19386136)1, 2, 9 Moroz O.V.... Bronstein I.B. (BMC Biochem. 2009)
  5. The three-dimensional structure of human S100A12. (PubMed id 11134923)1, 2, 9 Moroz O.V.... Bronstein I.B. (Acta Crystallogr. D 2001)
  6. Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. (PubMed id 11522286)1, 2, 9 Cole A.M.... Ganz T. (FEBS Lett. 2001)
  7. Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. (PubMed id 8619876)1, 2, 9 Marti T.... Gallin M.Y. (Biochem. Biophys. Res. Commun. 1996)
  8. Identification and characterization of a novel human neutrophil protein related to the S100 family. (PubMed id 7626002)1, 2, 9 Guignard F.... Markert M. (Biochem. J. 1995)
  9. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. (PubMed id 12042313)1, 2, 9 Filipek A.... Kuznicki J. (J. Biol. Chem. 2002)
  10. Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients. (PubMed id 21067798)1, 4 Rungroj N....Yenchitsomanus P.T. (Urology 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6283 HGNC: 10489 AceView: S100A12 Ensembl:ENSG00000163221 euGenes: HUgn6283
ECgene: S100A12 H-InvDB: S100A12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for S100A12 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for S100A12 gene:
Search GeneIP for patents involving S100A12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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