S100A11 Gene
protein-coding GIFtS: 56
GCID: GC01M152004
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|
S100 calcium binding protein A11(Previous names: S100 calcium-binding protein A11 (calgizzarin), S100 calcium...)
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Aliases
for S100A11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| S100 Calcium Binding Protein A111 2 | | MLN 702 3 | | S100C1 2 3 | | S100 Calcium Binding Protein A11 (Calgizzarin)1 | | S100 Calcium-Binding Protein A11 (Calgizzarin)1 2 | | Calgizzarin3 | | Metastatic Lymph Node Gene 70 Protein2 3 | | Protein S100-A112 | | Protein S100-C2 3 | | Calgizzarin3 | | MLN702 3 | | S100 Calcium-Binding Protein A113 |
Export aliases for S100A11 gene to outside databasesPrevious GC identifers: GC01M149845 GC01M147787 GC01M148780 GC01M149221 GC01M148818 GC01M150271 GC01M123382 |
Summaries
for S100A11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for S100A11:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-bindingmotifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in theregulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include atleast 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion,and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated intumor metastasis. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949Function: Facilitates the differentiation and the cornification of keratinocytes
Gene Wiki entry for S100A11
|
Genomic Views
for S100A11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the S100A11 gene promoter:
NF-1 Sp1 E4BP4 LCR-F1 RORalpha2 AREB6 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for S100A11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21S100A11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M152004: view genomic region
(about GC identifiers)
Start:
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152,004,982 bp from pter |
End:
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152,020,383 bp from pter |
Size:
|
15,402 bases |
Orientation:
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minus strand |
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Proteins
for S100A11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949 (See
protein sequence)Recommended Name: Protein S100-A11 Size: 105 amino acids; 11740 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins (Bysimilarity)
2 PDB 3D structures from  and Proteopedia  for S100A11:1V4Z (3D)
1V50 (3D)
Secondary accessions: Q5VTK0Explore the universe of human proteins at neXtProt for S100A11: NX_P31949
Post-translational modifications:
Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association withNCL/nucleolin which induces nuclear translocation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P31949
S100A11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005611.1
ENSEMBL proteins: ENSP00000271638
Human Recombinant Protein Products for S100A11:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
S100A11 for ontologies About GeneDecksing
S100A11 Antibody Products:
Assay Products for S100A11: |
Protein
Domains /
Families
for S100A11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
S100A11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P31949ProtoNet protein and cluster: P31949 1 Blocks protein family: IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949Similarity: Belongs to the S-100 familySimilarity: Contains 2 EF-hand domains |
Function
for S100A11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: S10AB_HUMAN, P31949Function: Facilitates the differentiation and the cornification of keratinocytes Genatlas biochemistry entry for S100A11:S100 calcium-binding protein A11,bovine CAAF1 homolog,expressed in polynuclear leukocytes,esophagus,epidermaldiffentiation complex
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
S100A11 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for S100a11):
S100A11 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out S100a11tm1Wen for S100A11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for S100A11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A11 |
|
Pathways & Interactions
for S100A11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/17 Interacting proteins for S100A11 (P319491, 3 ENSP000002716384) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
S100A11 for ontologies About GeneDecksing
|
Drugs & Compounds
for S100A11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
S100A11 for compounds About GeneDecksing
 Browse Tocris compounds for S100A11
1 HMDB Compound for S100A11 About this table
1 DrugBank Compound for S100A11 About this table
3 Novoseek chemical compound relationships for S100A11 gene About this table
Search CenterWatch for drugs/clinical trials and news about S100A11 / S10AB
|
Transcripts
for S100A11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for S100A11 gene: NM_005620.1 Unigene Cluster for S100A11: S100 calcium binding protein A11 Hs.417004 [show with all ESTs]Unigene Representative Sequence: BQ6838412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000271638(uc001ezn.3) ENST00000478109
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for S100A11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for S100A11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: S100A11 (NM_005620) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for S100A11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat S100A11 |
Additional cDNA sequence: AK312184.1 BC001410.2 BC014354.1 BT009912.1 D38583.1 D49355.1 D50374.1 X80201.1 21 DOTS entries: DT.120297 DT.99948256 DT.100893660 DT.85104134 DT.101987311 DT.100893645 DT.120299 DT.121459358 DT.121459337 DT.121459388 DT.95138982 DT.101986010 DT.101987309 DT.92048261 DT.100045727 DT.100837566 DT.95139080 DT.100033341 DT.120668866 DT.91768417 DT.91982121 24/774 AceView cDNA sequences (see all 774): BU931265 AA554821 AA917846 BE382768 BM855781 AI041086 AI754845 W46780 BM810353 AW883268 CB127680 BF198052 AW630673 AA292141 BE876844 AA680284 BM746746 BM470863 AW268346 AI074385 BG029409 W17181 BF589092 AI754449
GeneLoc Exon Structure
|
Expression
for S100A11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| S100A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGCCCCAC
About this image
See S100A11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for S100A11
SOURCE GeneReport for Unigene cluster: Hs.417004
SABiosciences Custom PCR Arrays for S100A11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for S100A11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat S100A11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat S100A11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A11 |
Orthologs
for S100A11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for S100A11 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
S100A111 |
S100 calcium binding protein A11 |
71.04(n)
74.75(a) |
|
396075 NM_205166.1 NP_990497.1 |
lizard
(Anolis carolinensis) |
Reptilia |
S100A116 |
-- |
66(a) |
1 ↔ 1 |
GL344049.1(73512-75721) |
zebrafish
(Danio rerio) |
Actinopterygii |
s100a116 |
S100 calcium binding protein A11 |
45(a) |
1 ↔ 1 |
19(8190299-8193011) |
ENSEMBL Gene Tree for S100A11 (if available)
TreeFam Gene Tree for S100A11 (if available) |
Paralogs
for S100A11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for S100A11 gene
- S100A62 S100A12 S100A122 S100A82 S100B2 S100A42 S100A32 S100A102
- S100Z2 S100A52 S100A22 S100P2 S100A92
18/24 SIMAP similar genes for S100A11 using alignment to 1 protein entry: S10AB_HUMAN(see all similar genes):S100A1 S100A4 S100B S100Z S100A10 S100P
S100A12 S100A6 TCHH HRNR S100A2 S100A9
S100G S100A13 S100A5 S100A3 FLG RPTN
S100A11 for paralogs About GeneDecksing
5/13 Pseudogenes.org Pseudogenes for S100A11 (see all 13)
PGOHUM00000242351 PGOHUM00000242634 PGOHUM00000239828 PGOHUM00000244632 PGOHUM00000233106
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Genomic Variants
for S100A11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for S100A11 (152004982 - 152020383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for S100A11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing S100A11 |
|
Disorders
/ Diseases
for S100A11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
S100A11 for disorders About GeneDecksing
OMIM gene information: 603114
OMIM disorders: --
20/29  diseases for S100A11 (see all 29): About MalaCardsgeneralized arterial calcification of infancy arterial calcification of infancy anaplastic large cell lymphoma clear cell sarcoma
arterial calcification esophageal squamous cell carcinoma squamous cell carcinoma pancreatic endocrine tumors
ocular melanoma pterygium colorectal cancer astrocytoma
vaccinia sarcoma hepatocellular carcinoma esophagitis
gastric cancer carcinoma psoriasis breast carcinoma
6 Novoseek disease relationships for S100A11 gene About this table
Human Genome Epidemiology (HuGE) Navigator: S100A11 (1 document)
Export disorders for S100A11 gene to outside databases
|
Publications
for S100A11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for S100A11 gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with S100A11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The structure of S100A11 fragment explains a local structural change induced by phosphorylation. (PubMed id 18618420)1, 2, 9 Kouno T.... Kawano K. (2008)
- Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. (PubMed id 7889529)1, 2, 9 Tanaka M.... Itakura M. (1995)
- Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PubMed id 8985590)1, 3, 9 Wicki R.... Heizmann C.W. (1996)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2 Tomasetto C.L.... Rio M.-C. (1995)
- Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
- Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments. (PubMed id 12645011)1, 9 Bianchi R....Donato R. (2003)
- Inhibition of S100A11 gene expression impairs keratin ocyte response against vaccinia virus through downregulation of the IL-10 recep tor 2 chain. (PubMed id 19577285)1, 9 Bin L....Leung D.Y. (2009)
- Colorectal cancer progression correlates with upregulation of S100A11 expression in tumor tissues. (PubMed id 18340452)1, 9 Wang G....Fu S. (2008)
|
External Searches for S100A11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing S100A11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing S100A11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing S100A11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for S100A11 gene:
Search GeneIP for patents involving S100A11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for S100A11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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