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S100A11 Gene

protein-coding   GIFtS: 60

GC01M150271
S100 calcium binding protein A11
(Previous names: S100 calcium-binding protein A11 (calgizzarin), S100 calcium binding protein A11 (calgizzarin) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
Calgizzarin 3
MLN70 2, 3
OTTHUMP00000015271 2
S100C 1, 2, 3
calgizzarin 2
Descriptions
MLN 70 3
Protein S100C 3
S100 calcium binding protein A11 2
S100 calcium binding protein A11 (calgizzarin) 1
S100 calcium-binding protein A11 3
S100 calcium-binding protein A11 (calgizzarin) 1, 2
External Ids
HGNC: 104881
Entrez Gene: 62822
UniProtKB: P319493
Ensembl: ENSG000001631917
Search outside databases for aliases for S100A11 gene

Previous GC identifers: GC01M149845 GC01M147787 GC01M148780 GC01M149221 GC01M148818

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A11:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin
polymerization. Chromosomal rearrangements and altered expression of this gene have been
implicated in tumor metastasis. [provided by RefSeq]

UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949
Function: Facilitates the differentiation and the cornification of keratinocytes

Gene Wiki entry for S100A11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A11 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150271:     (about GC identifiers)

Start:
150,271,606 bp from pter
End:
150,276,135 bp from pter
Size:
4,530 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949 (See protein sequence)
Recommended Name: Protein S100-A11  
Size: 105 amino acids; 11740 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S-100
proteins (By similarity)
PDB structure from and Proteopedia :
1V4Z (3D)    1V50 (3D)    
Secondary accessions: Q5VTK0

Post-translational modifications:

  • Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes
    association with NCL/nucleolin which induces nuclear translocation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005611.1  

    ENSEMBL proteins: 
    ENSP00000271638 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (S100A11)
    Human Recombinant Proteins from Abnova (S100A11)
                  OriGene Purified Recombinant Human Protein: S100A11 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726 ruffle IDA10913138
    GO:0005634 nucleus IDA10913138
    GO:0005737 cytoplasm TAS16130169
    About this table

    Antibodies for S100A11: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for S100A11
    R&D Systems Antibodies for S100A11
    Antibodies from Abcam (S100A11), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (S100A11)
    Novus Biologicals Antibodies for S100A11

    Assays for S100A11: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR018247 EF_HAND_1
     IPR011992 EF-Hand_type
     IPR018248 EF_hand
     IPR013787 S100_Ca_bd_sub
     IPR018249 EF_HAND_2


       GeneDecks  S100A11 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P31949

    ProtoNet protein and cluster: P31949

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005620

                  Applied Biosystems Silencer® siRNAs for S100A11

                  Sigma-Aldrich siRNA for S100A11  
                         Sigma-Aldrich shRNA for S100A11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for S100A11
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005620
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005620
                                     untagged cDNA clone in CMV expression vector: NM_005620 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005620

    UniProtKB/Swiss-Prot: S10AB_HUMAN, P31949
    Function: Facilitates the differentiation and the cornification of keratinocytes

    Genatlas biochemistry entry for S100A11:
    S100 calcium-binding protein A11,bovine CAAF1 homolog,expressed in polynuclear
    leukocytes,esophagus,epidermal diffentiation complex

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for S100a11):

    reproductive system

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509 calcium ion binding IEA--
    GO:0042803 protein homodimerization activity IDA10913138
    GO:0048154 S100 beta binding IPI10913138
    GO:0048306 calcium-dependent protein binding IDA10913138
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  S100A11 


    5/8 Interacting proteins for S100A11 (P319491 ENSP000002716383) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100BP042711EBI-701862, EBI-458391
    ANXA1ENSP000003661093STRING (score=.993)
    NCLENSP000003181953STRING (score=.974)
    ANXA6ENSP000003465503STRING (score=.939)
    IL8ENSP000003065123STRING (score=.855)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction TAS16130169
    GO:0008156 negative regulation of DNA replication TAS10851017
    GO:0008285 negative regulation of cell proliferation TAS10851017
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for S100A11
    3 Novoseek chemical compound relationships for S100A11 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 34.43 7 9599666 (1), 10913138 (1), 12645011 (1), 18385759 (1) (see all 5)
    glyceraldehyde 3-phosphate 28.89 1 16220529 (1)
    atp 0.00 1 16220529 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005620

                  Sigma-Aldrich siRNA for S100A11  
                         Sigma-Aldrich shRNA for S100A11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005620  

    REFSEQ mRNAs for S100A11 gene: 

    NM_005620.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005620  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005620
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005620
                                     untagged cDNA clone in CMV expression vector: NM_005620 

    Additional cDNA sequence: 

    AK312184.1 BC001410.2 BC014354.1 BT009912.1 CR594638.1 CR619623.1 D38583.1 D49355.1 
    D50374.1 X80201.1 

    21 DOTS entries:

    DT.120297  DT.99948256  DT.100893660  DT.85104134  DT.101987311  DT.100893645  DT.120299  DT.121459358 
    DT.121459337  DT.121459388  DT.95138982  DT.101986010  DT.101987309  DT.92048261  DT.100045727  DT.95139080 
    DT.100033341  DT.100837566  DT.120668866  DT.91768417  DT.91982121 

    24/774 AceView cDNA sequences (see all 774 ):

    AA657955 BE904983 AI041086 BQ668893 BE885104 BM504088 F31230 CD671964 
    AA363879 BM691349 AA358310 BQ549827 AW604799 AA723038 BU521428 BE876844 
    BF477783 AA858395 BU789897 BQ016616 AW836325 AW583803 CB149858 BE382768 

    highest scoring ESTs for S100A11:

    AA022942 AA031606 AA053457 AA055092 AA075780 AA188116 AA216335 AA292009 AA292141 AA296586 

    Unigene Cluster for S100A11:

    S100 calcium binding protein A11
    Hs.417004  [show with all ESTs]
    Unigene Representative Sequence: BQ683841


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000271638  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    S100A11 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for S100A11

    1 / 2 / 3

    4 probe-sets matching S100A11 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38138_at2, 3 U95-A 6 1.00 0.53 0.98 0.96 AC004668 0.20 1.00 0.72 1
    71526_f_at2, 3 U95-D 2 0.31 0.80 0.97 1.04 AI686949 0.40 1.00 0.76 1

    200660_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005620 0.60 1.00 0.82 1

    200660_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  S100A11 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAGGCCCCAC

    SOURCE GeneReport for Unigene cluster: Hs.417004

    Expression variation in blood from EXPOLDB for S100A11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for S100A11 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4758521   -- similar to Calgizzarin (S100 calcium-binding protein more 89.46(n)
    86.73(a)
    475852  XM_533061.2  XP_533061.1 
    chimpanzee
    (Pan troglodytes)
    S100A111   -- S100 calcium binding protein A11 99.05(n)
    100(a)
    457994  XM_514427.2  XP_514427.1 
    cow
    (Bos taurus)
    S100A111   -- S100 calcium binding protein A11 (calgizzarin) 85.76(n)
    83.5(a)
    337886  XM_595126.3  XP_595126.3 
    rat
    (Rattus norvegicus)
    S100a111   -- S100 calcium binding protein A11 (calizzarin) 84.72(n)
    88.54(a)
    445415  NM_001004095.1  NP_001004095.1 
    mouse
    (Mus musculus)
    S100a115
    EG2770891
    35
    S100 calcium binding protein A11 (calgizzarin)5
    predicted gene, EG2770891
    81.25(n)1
    85.42(a)1
    2770891  XM_204772.41  XP_204772.41 
     AA2075245  AK0024905  (see all 11)
    About this table        Species with no ortholog for S100A11

    ENSEMBL Gene Tree for S100A11
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for S100A11 gene
    S100A102  

    Pseudogenes
    9 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/35 NCBI SNPs in S100A11 are shown (see all 35 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 37)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs121239751,2
    A,C,F,H150271428(+) ATAACA/GATAAG 1 -- ng5115Minor allele frequency- G:0.23EU EA WA NA 1398
    rs31223011,2
    C,F,H150277349(-) TTTTTT/AAGTGC 1 -- ng314Minor allele frequency- A:0.05EU EA WA 418
    rs38114221,2
    A,C,F150276154(+) ACAGCC/TTCCGC 1 -- ng311Minor allele frequency- T:0.03EA 1466
    --
    rs31223021,2
    A,C150276940(-) ccacgC/Tccggc 1 -- ng310--------
    rs67021721,2
    F,H150276021(+) GTTGGA/CGCTGA 1 -- ut51 ese34Minor allele frequency- C:0.01EU EA WA 410
    --
    rs115505781,2
    H150272798(-) TCTCCA/GAGACA 1 K/E mis1 ese34Minor allele frequency- G:0.00EU EA WA 404
    rs30076751,2
    H150271258(+) tgtaaT/Actgtc 1 -- ng514Minor allele frequency- A:0.00EU EA WA 378
    --
    rs30883811,2
    H150271724(-) CCTTTC/TCTTCC 1 -- ut31 trp35Minor allele frequency- T:0.14MN EU EA WA 602
    rs46349121,2
    A,C,F,H150275295(+) AGAAAG/TAGATT 1 -- int1 trp34Minor allele frequency- T:0.01EU EA WA 390
    rs30076761,2
    A,C,F,H150274223(+) TTTGCT/CCTAAA 1 -- int14Minor allele frequency- C:0.11EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for S100A11 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603114

    6 Novoseek disease relationships for S100A11 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 24.54 1 10913138 (1)
    colorectal cancer 19.65 8 18340452 (6), 7889529 (1)
    primary tumor 19.08 1 19048101 (1)
    tumors 8.21 5 18340452 (2), 15668896 (2), 9920419 (1)
    cancer 1.79 9 15720411 (4), 15668896 (3)
    metastasis 0.00 3 19048101 (2), 17523080 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/83 PubMed articles for S100A11 gene (see all 83 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6282 HGNC: 10488 AceView: S100A11 Ensembl:ENSG00000163191 euGenes: HUgn6282
    ECgene: S100A11 H-InvDB: S100A11
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for S100A11 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for S100A11:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for S100A11 Antibodies for S100A11
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for S100A11 Browse small molecules at Sigma-Aldrich
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for S100A11




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for S100A11

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