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Aliases for S100A11 Gene

Aliases for S100A11 Gene

  • S100 Calcium Binding Protein A11 2 3
  • S100 Calcium-Binding Protein A11 (Calgizzarin) 2 3
  • Metastatic Lymph Node Gene 70 Protein 3 4
  • Protein S100-C 3 4
  • Calgizzarin 3 4
  • MLN 70 3 4
  • MLN70 3 4
  • S100C 3 4
  • S100 Calcium Binding Protein A11 (Calgizzarin) 2
  • Epididymis Secretory Protein Li 43 3
  • S100 Calcium-Binding Protein A11 4
  • Protein S100-A11 3
  • HEL-S-43 3

External Ids for S100A11 Gene

Summaries for S100A11 Gene

Entrez Gene Summary for S100A11 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A11 Gene

S100A11 (S100 Calcium Binding Protein A11) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A11 Gene

  • Facilitates the differentiation and the cornification of keratinocytes.

Gene Wiki entry for S100A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A11 Gene

Genomics for S100A11 Gene

Genomic Location for S100A11 Gene

Start:
152,032,506 bp from pter
End:
152,047,907 bp from pter
Size:
15,402 bases
Orientation:
Minus strand

Genomic View for S100A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A11 Gene

Regulatory Elements for S100A11 Gene

Proteins for S100A11 Gene

  • Protein details for S100A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31949-S10AB_HUMAN
    Recommended name:
    Protein S100-A11
    Protein Accession:
    P31949
    Secondary Accessions:
    • Q5VTK0

    Protein attributes for S100A11 Gene

    Size:
    105 amino acids
    Molecular mass:
    11740 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    Miscellaneous:
    • Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.

    Three dimensional structures from OCA and Proteopedia for S100A11 Gene

neXtProt entry for S100A11 Gene

Proteomics data for S100A11 Gene at MOPED

Post-translational modifications for S100A11 Gene

  • Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys27 and Lys55

Other Protein References for S100A11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A11 Gene

Domains for S100A11 Gene

Gene Families for S100A11 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

UniProtKB/Swiss-Prot:

S10AB_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • P31949
Family:
  • Belongs to the S-100 family.:
    • P31949
genes like me logo Genes that share domains with S100A11: view

Function for S100A11 Gene

Molecular function for S100A11 Gene

GENATLAS Biochemistry: S100 calcium-binding protein A11,bovine CAAF1 homolog,expressed in polynuclear leukocytes,esophagus,epidermal diffentiation complex
UniProtKB/Swiss-Prot Function: Facilitates the differentiation and the cornification of keratinocytes.

Gene Ontology (GO) - Molecular Function for S100A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10913138
GO:0042803 protein homodimerization activity IDA 10913138
GO:0044548 S100 protein binding IPI 10913138
GO:0048306 calcium-dependent protein binding IDA 10913138
genes like me logo Genes that share ontologies with S100A11: view

Phenotypes for S100A11 Gene

MGI mutant phenotypes for S100A11:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with S100A11: view

Animal Models for S100A11 Gene

MGI Knock Outs for S100A11:

miRNA for S100A11 Gene

miRTarBase miRNAs that target S100A11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for S100A11 Gene

Localization for S100A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A11 Gene COMPARTMENTS Subcellular localization image for S100A11 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for S100A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 10913138
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with S100A11: view

Pathways for S100A11 Gene

SuperPathways for S100A11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 16130169
GO:0008156 negative regulation of DNA replication TAS 10851017
GO:0008285 negative regulation of cell proliferation TAS 10851017
genes like me logo Genes that share ontologies with S100A11: view

No data available for Pathways by source for S100A11 Gene

Compounds for S100A11 Gene

(1) HMDB Compounds for S100A11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for S100A11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphonothreonine
target

(3) Novoseek inferred chemical compound relationships for S100A11 Gene

Compound -log(P) Hits PubMed IDs
calcium 36.1 6
glyceraldehyde 3-phosphate 26.6 1
atp 0 1
genes like me logo Genes that share compounds with S100A11: view

Transcripts for S100A11 Gene

mRNA/cDNA for S100A11 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(774) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A11 Gene

S100 calcium binding protein A11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A11 Gene

No ASD Table

Relevant External Links for S100A11 Gene

GeneLoc Exon Structure for
S100A11
ECgene alternative splicing isoforms for
S100A11

Expression for S100A11 Gene

mRNA expression in normal human tissues for S100A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A11 Gene

This gene is overexpressed in Whole Blood (17.4) and Esophagus - Mucosa (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A11 Gene

SOURCE GeneReport for Unigene cluster for S100A11 Gene Hs.417004

genes like me logo Genes that share expressions with S100A11: view

Orthologs for S100A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A11 36
  • 99.05 (n)
  • 100 (a)
S100A11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100A11 36
  • 85.76 (n)
  • 83.5 (a)
S100A11 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A11 36
  • 89.46 (n)
  • 86.73 (a)
S100A11 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5068 36
  • 81.25 (n)
  • 85.42 (a)
S100a11 16
S100a11 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A11 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S100A11 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a11 36
  • 84.72 (n)
  • 88.54 (a)
chicken
(Gallus gallus)
Aves S100A11 36
  • 71.04 (n)
  • 74.75 (a)
S100A11 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S100A11 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s100a11 36
  • 62.15 (n)
  • 55.21 (a)
zebrafish
(Danio rerio)
Actinopterygii s100a10a 37
  • 44 (a)
ManyToMany
s100a10b 37
  • 41 (a)
ManyToMany
Species with no ortholog for S100A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A11 Gene

ENSEMBL:
Gene Tree for S100A11 (if available)
TreeFam:
Gene Tree for S100A11 (if available)

Paralogs for S100A11 Gene

Selected SIMAP similar genes for S100A11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A11: view

Variants for S100A11 Gene

Sequence variations from dbSNP and Humsavar for S100A11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4883 -- 152,032,667(-) AGCGG(A/C)CCTGA reference, missense
rs1802517 -- 152,033,746(-) TTGCT(G/T)TCTTC reference, missense
rs1803300 -- 152,033,711(-) TATAA(C/T)TACAC reference, synonymous-codon
rs2999550 -- 152,033,006(+) CTGGG(C/G)CTTGA intron-variant
rs2999551 -- 152,035,833(+) CTAAG(A/C)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A11 Gene

Variant ID Type Subtype PubMed ID
nsv872441 CNV Gain 21882294

Relevant External Links for S100A11 Gene

HapMap Linkage Disequilibrium report
S100A11

Disorders for S100A11 Gene

(6) Novoseek inferred disease relationships for S100A11 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 22.4 1
colorectal cancer 16.6 7
primary tumor 16.4 1
tumors 4.92 5
cancer 2.64 7

Relevant External Links for S100A11

Genetic Association Database (GAD)
S100A11
Human Genome Epidemiology (HuGE) Navigator
S100A11
genes like me logo Genes that share disorders with S100A11: view

No data available for UniProtKB/Swiss-Prot for S100A11 Gene

Publications for S100A11 Gene

  1. Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. (PMID: 7889529) Tanaka M. … Itakura M. (Cancer Lett. 1995) 3 4 23
  2. Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PMID: 8985590) Wicki R. … Heizmann C.W. (Cell Calcium 1996) 2 3 23
  3. The structure of S100A11 fragment explains a local structural change induced by phosphorylation. (PMID: 18618420) Kouno T. … Kawano K. (J. Pept. Sci. 2008) 3 4 23
  4. Members of the S100 family bind p53 in two distinct ways. (PMID: 18694925) Fernandez-Fernandez M.R. … Fersht A.R. (Protein Sci. 2008) 3 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for S100A11 Gene

Sources for S100A11 Gene

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