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Aliases for S100A10 Gene

Aliases for S100A10 Gene

  • S100 Calcium Binding Protein A10 2 3 5
  • S100 Calcium-Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)) 2 3
  • S100 Calcium Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)) 2 3
  • Annexin II Tetramer (AIIt) P11 Subunit 2 3
  • Cellular Ligand Of Annexin II 3 4
  • Calpactin I Light Chain 3 4
  • Calpactin-1 Light Chain 3 4
  • ANX2LG 3 4
  • CAL1L 3 4
  • CLP11 3 4
  • P11 3 4
  • Annexin II Ligand, Calpactin I, Light Polypeptide 3
  • S100 Calcium-Binding Protein A10 4
  • P10 Protein 4
  • ANX2L 3
  • Ca[1] 3
  • GP11 3
  • P10 3
  • 42C 3

External Ids for S100A10 Gene

Previous HGNC Symbols for S100A10 Gene

  • ANX2LG
  • CAL1L

Previous GeneCards Identifiers for S100A10 Gene

  • GC01M149796
  • GC01M147738
  • GC01M148730
  • GC01M149171
  • GC01M148768
  • GC01M150224
  • GC01M123333

Summaries for S100A10 Gene

Entrez Gene Summary for S100A10 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A10 Gene

S100A10 (S100 Calcium Binding Protein A10) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A10 Gene

  • Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Gene Wiki entry for S100A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A10 Gene

Genomics for S100A10 Gene

Regulatory Elements for S100A10 Gene

Promoters for S100A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S100A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A10 Gene

Chromosome:
1
Start:
151,982,910 bp from pter
End:
151,994,390 bp from pter
Size:
11,481 bases
Orientation:
Minus strand

Genomic View for S100A10 Gene

Genes around S100A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A10 Gene

Proteins for S100A10 Gene

  • Protein details for S100A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60903-S10AA_HUMAN
    Recommended name:
    Protein S100-A10
    Protein Accession:
    P60903
    Secondary Accessions:
    • A8K4V8
    • P08206
    • Q5T1C5

    Protein attributes for S100A10 Gene

    Size:
    97 amino acids
    Molecular mass:
    11203 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).
    Miscellaneous:
    • Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

    Three dimensional structures from OCA and Proteopedia for S100A10 Gene

neXtProt entry for S100A10 Gene

Proteomics data for S100A10 Gene at MOPED

Post-translational modifications for S100A10 Gene

  • Ubiquitination at Lys 18, Lys 37, Lys 47, and Lys 54
  • Modification sites at PhosphoSitePlus

Other Protein References for S100A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S100A10 Gene

Domains & Families for S100A10 Gene

Gene Families for S100A10 Gene

Protein Domains for S100A10 Gene

Graphical View of Domain Structure for InterPro Entry

P60903

UniProtKB/Swiss-Prot:

S10AA_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A10: view

Function for S100A10 Gene

Molecular function for S100A10 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A10,epidermal differentiation complex
UniProtKB/Swiss-Prot Function:
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Gene Ontology (GO) - Molecular Function for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14699089
GO:0042803 protein homodimerization activity IDA 23091277
genes like me logo Genes that share ontologies with S100A10: view
genes like me logo Genes that share phenotypes with S100A10: view

Animal Models for S100A10 Gene

MGI Knock Outs for S100A10:

Animal Model Products

  • Taconic Biosciences Mouse Models for S100A10

miRNA for S100A10 Gene

miRTarBase miRNAs that target S100A10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A10 Gene

Localization for S100A10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A10 Gene COMPARTMENTS Subcellular localization image for S100A10 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2
mitochondrion 2
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for S100A10 Gene

Pathways & Interactions for S100A10 Gene

genes like me logo Genes that share pathways with S100A10: view

Pathways by source for S100A10 Gene

1 BioSystems pathway for S100A10 Gene
2 Reactome pathways for S100A10 Gene
1 GeneGo (Thomson Reuters) pathway for S100A10 Gene

Gene Ontology (GO) - Biological Process for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IDA 23861394
GO:0006900 membrane budding IDA 23861394
GO:0043547 positive regulation of GTPase activity IMP 23129259
GO:0051099 positive regulation of binding IEA --
GO:0051894 positive regulation of focal adhesion assembly IMP 23129259
genes like me logo Genes that share ontologies with S100A10: view

No data available for SIGNOR curated interactions for S100A10 Gene

Drugs & Compounds for S100A10 Gene

(4) Drugs for S100A10 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for S100A10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A10: view

Transcripts for S100A10 Gene

Unigene Clusters for S100A10 Gene

S100 calcium binding protein A10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A10 Gene

No ASD Table

Relevant External Links for S100A10 Gene

GeneLoc Exon Structure for
S100A10
ECgene alternative splicing isoforms for
S100A10

Expression for S100A10 Gene

mRNA expression in normal human tissues for S100A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A10 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for S100A10 Gene

This gene is overexpressed in Nasopharynx (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A10 Gene



SOURCE GeneReport for Unigene cluster for S100A10 Gene Hs.143873

genes like me logo Genes that share expression patterns with S100A10: view

Protein tissue co-expression partners for S100A10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for S100A10 Gene

Orthologs for S100A10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A10 35
  • 94.16 (n)
  • 100 (a)
S100A10 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A10 35
  • 92.78 (n)
  • 98.97 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia S100a10 35
  • 89.69 (n)
  • 91.75 (a)
S100a10 16
S100a10 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100A10 35
  • 99.66 (n)
  • 100 (a)
S100A10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a10 35
  • 90.07 (n)
  • 91.49 (a)
oppossum
(Monodelphis domestica)
Mammalia S100A10 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves S100A10 35
  • 78.69 (n)
  • 89.69 (a)
S100A10 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S100A10 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11404 35
zebrafish
(Danio rerio)
Actinopterygii s100a10b 35
  • 57.39 (n)
  • 52.58 (a)
s100a10a 36
  • 47 (a)
ManyToMany
s100a10b 36
  • 50 (a)
ManyToMany
Species with no ortholog for S100A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A10 Gene

ENSEMBL:
Gene Tree for S100A10 (if available)
TreeFam:
Gene Tree for S100A10 (if available)

Paralogs for S100A10 Gene

Pseudogenes.org Pseudogenes for S100A10 Gene

genes like me logo Genes that share paralogs with S100A10: view

Variants for S100A10 Gene

Sequence variations from dbSNP and Humsavar for S100A10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1055624 -- 151,983,101(-) GGAAT(C/T)TGCCC utr-variant-3-prime
rs1387834 -- 151,982,576(-) ATCCA(A/T)TTTTC downstream-variant-500B
rs1387835 -- 151,982,416(-) GCAGT(A/G)CACTT downstream-variant-500B
rs1803286 -- 151,982,948(-) CCTTG(A/C)CCTCA utr-variant-3-prime
rs1803287 -- 151,983,165(-) AGAAG(C/T)AGGCA reference, stop-lost

Structural Variations from Database of Genomic Variants (DGV) for S100A10 Gene

Variant ID Type Subtype PubMed ID
nsv872441 CNV Gain 21882294
nsv2855 CNV Loss 18451855

Variation tolerance for S100A10 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for S100A10 Gene

HapMap Linkage Disequilibrium report
S100A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A10 Gene

Disorders for S100A10 Gene

Relevant External Links for S100A10

Genetic Association Database (GAD)
S100A10
Human Genome Epidemiology (HuGE) Navigator
S100A10
Tumor Gene Database (TGDB):
S100A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A10

No disorders were found for S100A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A10 Gene

Publications for S100A10 Gene

  1. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. (PMID: 18838110) Tzang R.F. … Tsai S.J. (Neurosci. Lett. 2008) 3 23 48 67
  2. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. (PMID: 8276421) Volz A. … Mischke D. (Genomics 1993) 2 3 23
  3. Annexins sense changes in intracellular pH during hypoxia. (PMID: 17824845) Monastyrskaya K. … Draeger A. (Biochem. J. 2008) 3 23
  4. The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants. (PMID: 16890384) Tsai S.J. (Med. Hypotheses 2007) 3 23
  5. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. (PMID: 17241856) Camilleri M. … Coulie B. (Gastroenterology 2007) 3 23

Products for S100A10 Gene

Sources for S100A10 Gene

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