S100A10 Gene
protein-coding GIFtS : 63
GC01M150224
S100 calcium binding protein A10 (Previous names: S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)), S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: ANX2LG, CAL1L )
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Aliases & Descriptions for S100A10
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 42C 1 , 2 ANX2L 2 ANX2LG 2 , 3 CAL1L 2 , 3 , 5 CLP11 1 , 2 , 3 Ca[1] 2 GP11 2 MGC111133 2 OTTHUMP00000015269 2 OTTHUMP00000015270 2 P11 1 , 2 p10 2 p11 3
Descriptions Calpactin I light chain 3 Calpactin-1 light chain 3 Cellular ligand of annexin II 3 S100 calcium binding protein A10 2 S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) 1 , 2 S100 calcium-binding protein A10 3 S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) 1 , 2 annexin II ligand, calpactin I, light polypeptide 2 p10 protein 3
Search outside databases for aliases for S100A10 genePrevious GC identifers: GC01M149796 GC01M147738 GC01M148730 GC01M149171 GC01M148768
Summaries for S100A10 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for S100A10 : The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-handcalcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a widerange of cells, and involved in the regulation of a number of cellular processes such as cellcycle progression and differentiation. S100 genes include at least 13 members which are located asa cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [providedby RefSeq] UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 Function : Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator ofprotein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) oftyrosine-specific kinase
Gene Wiki entry for S100A10
Genomic Location for S100A10
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the S100A10 gene Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21 S100A10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M150224:
(about GC identifiers )
Start:
150,222,010 bp from pter
End:
150,233,338 bp from pter
Size:
11,329 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for S100A10
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 (See
protein sequence )Recommended Name: Protein S100-A10 Size : 97 amino acids; 11203 Da
Subunit : Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.Interacts with SCN10A (By similarity)
Miscellaneous : Does not appear to bind calcium. Contains 2 ancestral calcium site related toEF-hand domains that have lost their ability to bind calcium
PDB structure from and Proteopedia : 1A4P (3D)
 1BT6 (3D)
 
Secondary accessions : A8K4V8 P08206 Q5T1C5
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_002957.1 ENSEMBL proteins: ENSP00000357801 ENSP00000357799 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: S100A10 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for S100A10: Assays for S100A10:
Protein
Domains/ Families for S100A10(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P60903 ProtoNet protein and cluster: P60903
1 Blocks protein family : IPB001751 Calcium-binding protein UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 Similarity : Belongs to the S-100 family
Gene Function for S100A10
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002966 Applied Biosystems Silencer ® siRNAs for S100A10 Sigma-Aldrich siRNA for S100A10 Sigma-Aldrich shRNA for S100A10 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002966                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002966                                  untagged cDNA clone in CMV expression vector: NM_002966  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002966 UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 Function : Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator ofprotein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) oftyrosine-specific kinase
Genatlas biochemistry entry for S100A10 :S100 calcium binding protein A10,epidermal differentiation complex
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for S100a10) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for S100A10
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for S100A10 5/20 Interacting proteins for S100A10 (ENSP00000357799 3 P60903 2 ) via UniProtKB, MINT, and/or STRING (see all 20
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
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Drugs & Compounds for S100A10 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for S100A10 5 Novoseek chemical compound relationships for S100A10 gene
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Transcripts for S100A10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002966 Sigma-Aldrich siRNA for S100A10 Sigma-Aldrich shRNA for S100A10 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002966
REFSEQ mRNAs for S100A10 gene: NM_002966.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002966
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002966                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002966                                  untagged cDNA clone in CMV expression vector: NM_002966  
Additional cDNA sequence: AK291073.1 BC015973.1 BC105786.1 CR542162.1 CR610742.1 D28387.1 M38591.1 M81457.1
16 DOTS entries : DT.454560 DT.99982891 DT.100705295 DT.100803818 DT.121459339 DT.40208575 DT.421628 DT.40208585 DT.91951004 DT.121459332 DT.95261042 DT.100753245 DT.121459342 DT.121459360 DT.87078284 DT.95261112
24/552 AceView cDNA sequences (see all 552
):CR610742 BU860855 AW273757 N92309 BQ953124 H28632 T94662 AI144406 BM541737 AI983171 AA376850 CB158822 AW328273 T62220 W93998 AA973779 BQ051331 BG926612 BM842132 BM672556 W17136 AA326781 AA733076 R12568
highest scoring ESTs for S100A10 :AI201310 AA041412 AA299282 AA308139 AA313935 AA360215 AA369182 AA373194 AA385107 AA868542
Unigene Cluster for S100A10: S100 calcium binding protein A10 Hs.143873 [show with all ESTs ] Unigene Representative Sequence: CD388106 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000368811
ENST00000368809
Expression for S100A10
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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S100A10 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for S100A10 1 / 2 / 3
3 probe-sets matching S100A10 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGCAGATCAGSOURCE GeneReport for Unigene cluster: Hs.143873 Expression variation in blood from EXPOLDB for S100A10
Orthologs for S100A10
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for S100A10 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for S100A10 ENSEMBL Gene Tree for S100A10 Paralogs for S100A10 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for S100A10 gene S100A11 2
SNPs/Variants for S100A10 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for S100A10 (up to first 250kb)
Disorders & Mutations for S100A10
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 114085 3 Novoseek disease relationships for S100A10 gene
About this table 1 PharmGKB disease relationship for S100A10 gene About this table Human Genome Epidemiology Navigator: S100A10 (3 documents) Tumor Gene Database : S100A10
Medical News for S100A10 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for S100A10 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/84 PubMed articles for S100A10 gene (see all 84
): Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II. (PubMed id 1831433) 1, 3, 4 Kube E.... Gerke V. (1991) Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. (PubMed id 1533380) 1, 3, 4 Harder T.... Gerke V. (1992) cDNA sequence of human p11 calpactin I light chain. (PubMed id 1386341) 1, 3, 4 Dooley T.P.... Simon M. (1992) Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. (PubMed id 8276421) 1, 2, 3 Volz A....Mischke D. (1993) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The crystal structure of a complex of p11 with the annexin II N- terminal peptide. (PubMed id 9886297) 3, 4 Rety S.... Lewit-Bentley A. (1999) Interferon-gamma induces p11 gene and protein expression in human epithelial cells through interferon-gamma-activated sequences in the p11 promoter. (PubMed id 12645529) 1, 3 Huang X.L....Shelhamer J.H. (2003) S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. (PubMed id 15574370) 1, 3 Kwon M....Waisman D.M. (2005) Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells. (PubMed id 12163506) 1, 3 Huang X.L....Shelhamer J.H. (2002)
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Genome Databases showing S100A10
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing S100A10
(According to HUGE )
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Specialized Databases showing S100A10 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for S100A10 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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