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Aliases for S100A10 Gene

Aliases for S100A10 Gene

  • S100 Calcium Binding Protein A10 2 3
  • CAL1L 3 4 6
  • S100 Calcium-Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)) 2 3
  • S100 Calcium Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)) 2 3
  • Annexin II Tetramer (AIIt) P11 Subunit 2 3
  • Cellular Ligand Of Annexin II 3 4
  • Calpactin I Light Chain 3 4
  • Calpactin-1 Light Chain 3 4
  • ANX2LG 3 4
  • CLP11 3 4
  • P11 3 4
  • Annexin II Ligand, Calpactin I, Light Polypeptide 3
  • S100 Calcium-Binding Protein A10 4
  • Protein S100-A10 3
  • P10 Protein 4
  • ANX2L 3
  • Ca[1] 3
  • GP11 3
  • P10 3
  • 42C 3

External Ids for S100A10 Gene

Previous Symbols for S100A10 Gene

  • ANX2LG
  • CAL1L

Summaries for S100A10 Gene

Entrez Gene Summary for S100A10 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A10 Gene

S100A10 (S100 Calcium Binding Protein A10) is a Protein Coding gene. Diseases associated with S100A10 include borna disease. Among its related pathways are Regulation of CFTR activity (norm and CF) and Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A10 Gene

  • Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

Gene Wiki entry for S100A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A10 Gene

Genomics for S100A10 Gene

Genomic Location for S100A10 Gene

Start:
151,982,910 bp from pter
End:
151,994,390 bp from pter
Size:
11,481 bases
Orientation:
Minus strand

Genomic View for S100A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A10 Gene

Regulatory Elements for S100A10 Gene

Proteins for S100A10 Gene

  • Protein details for S100A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60903-S10AA_HUMAN
    Recommended name:
    Protein S100-A10
    Protein Accession:
    P60903
    Secondary Accessions:
    • A8K4V8
    • P08206
    • Q5T1C5

    Protein attributes for S100A10 Gene

    Size:
    97 amino acids
    Molecular mass:
    11203 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).
    Miscellaneous:
    • Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium

    Three dimensional structures from OCA and Proteopedia for S100A10 Gene

neXtProt entry for S100A10 Gene

Proteomics data for S100A10 Gene at MOPED

Post-translational modifications for S100A10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys37, Lys47, Lys54, and Lys57

Other Protein References for S100A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A10 Gene

Domains for S100A10 Gene

Gene Families for S100A10 Gene

HGNC:
  • S100 :S100 calcium binding proteins

Protein Domains for S100A10 Gene

UniProtKB/Swiss-Prot:

S10AA_HUMAN
Family:
  • Belongs to the S-100 family.:
    • P60903
genes like me logo Genes that share domains with S100A10: view

Function for S100A10 Gene

Molecular function for S100A10 Gene

GENATLAS Biochemistry: S100 calcium binding protein A10,epidermal differentiation complex
UniProtKB/Swiss-Prot Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

Gene Ontology (GO) - Molecular Function for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 14699089
GO:0008289 NOT lipid binding IDA 23861394
GO:0042803 protein homodimerization activity IDA 23091277
GO:0044325 ion channel binding IPI 12198146
genes like me logo Genes that share ontologies with S100A10: view
genes like me logo Genes that share phenotypes with S100A10: view

Animal Models for S100A10 Gene

MGI Knock Outs for S100A10:

miRNA for S100A10 Gene

miRTarBase miRNAs that target S100A10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for S100A10 Gene

Localization for S100A10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A10 Gene COMPARTMENTS Subcellular localization image for S100A10 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2
endosome 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019897 extrinsic component of plasma membrane IEA --
GO:0045121 colocalizes_with membrane raft IDA 14699089
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with S100A10: view

Pathways for S100A10 Gene

genes like me logo Genes that share pathways with S100A10: view

Pathways by source for S100A10 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for S100A10 Gene
1 BioSystems pathway for S100A10 Gene

Gene Ontology (GO) - Biological Process for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IDA 23861394
GO:0006900 membrane budding IDA 23861394
GO:0043547 positive regulation of GTPase activity IMP 23129259
GO:0051099 positive regulation of binding IEA --
GO:0051290 protein heterotetramerization IDA 23091277
genes like me logo Genes that share ontologies with S100A10: view

Compounds for S100A10 Gene

(1) HMDB Compounds for S100A10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) Novoseek inferred chemical compound relationships for S100A10 Gene

Compound -log(P) Hits PubMed IDs
arachidonic acid 34.8 7
phospholipid 25.4 1
calcium 21.7 3
tyrosine 12.8 5
lysine 9.08 2
genes like me logo Genes that share compounds with S100A10: view

Transcripts for S100A10 Gene

mRNA/cDNA for S100A10 Gene

Unigene Clusters for S100A10 Gene

S100 calcium binding protein A10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A10 Gene

No ASD Table

Relevant External Links for S100A10 Gene

GeneLoc Exon Structure for
S100A10
ECgene alternative splicing isoforms for
S100A10

Expression for S100A10 Gene

mRNA expression in normal human tissues for S100A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A10 Gene

This gene is overexpressed in Esophagus - Mucosa (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A10 Gene

SOURCE GeneReport for Unigene cluster for S100A10 Gene Hs.143873

genes like me logo Genes that share expressions with S100A10: view

Orthologs for S100A10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A10 36
  • 99.66 (n)
  • 100 (a)
S100A10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100A10 36
  • 94.16 (n)
  • 100 (a)
S100A10 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
OneToMany
S100A10 36
  • 92.78 (n)
  • 98.97 (a)
mouse
(Mus musculus)
Mammalia S100a10 36
  • 89.69 (n)
  • 91.75 (a)
S100a10 16
S100a10 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A10 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a10 36
  • 90.07 (n)
  • 91.49 (a)
chicken
(Gallus gallus)
Aves S100A10 36
  • 78.69 (n)
  • 89.69 (a)
S100A10 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S100A10 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11404 36
zebrafish
(Danio rerio)
Actinopterygii s100a10a 37
  • 47 (a)
ManyToMany
s100a10b 36
  • 57.39 (n)
  • 52.58 (a)
s100a10b 37
  • 50 (a)
ManyToMany
Species with no ortholog for S100A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A10 Gene

ENSEMBL:
Gene Tree for S100A10 (if available)
TreeFam:
Gene Tree for S100A10 (if available)

Paralogs for S100A10 Gene

Pseudogenes.org Pseudogenes for S100A10 Gene

genes like me logo Genes that share paralogs with S100A10: view

Variants for S100A10 Gene

Sequence variations from dbSNP and Humsavar for S100A10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1038745 -- 151,994,269(-) GGACT(A/C)CACGT upstream-variant-2KB
rs1055624 -- 151,983,101(-) GGAAT(C/T)TGCCC utr-variant-3-prime
rs1387834 -- 151,982,576(-) ATCCA(A/T)TTTTC downstream-variant-500B
rs1387835 -- 151,982,416(-) GCAGT(A/G)CACTT downstream-variant-500B
rs1552607 -- 151,990,922(-) TACTC(C/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for S100A10 Gene

Variant ID Type Subtype PubMed ID
nsv872441 CNV Gain 21882294
nsv2855 CNV Loss 18451855

Relevant External Links for S100A10 Gene

HapMap Linkage Disequilibrium report
S100A10

Disorders for S100A10 Gene

(1) MalaCards Diseases for S100A10 Gene

Search for S100A10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for S100A10 Gene

(3) Novoseek inferred disease relationships for S100A10 Gene

Disease -log(P) Hits PubMed IDs
metastasis 0 5
tumors 0 4
cancer 0 6

Relevant External Links for S100A10

Genetic Association Database (GAD)
S100A10
Human Genome Epidemiology (HuGE) Navigator
S100A10
Tumor Gene Database (TGDB):
S100A10
genes like me logo Genes that share disorders with S100A10: view

No data available for UniProtKB/Swiss-Prot for S100A10 Gene

Publications for S100A10 Gene

  1. cDNA sequence of human p11 calpactin I light chain. (PMID: 1386341) Dooley T.P. … Simon M. (Genomics 1992) 3 4 23
  2. Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. (PMID: 1533380) Harder T. … Gerke V. (Gene 1992) 3 4 23
  3. Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II. (PMID: 1831433) Kube E. … Gerke V. (Gene 1991) 3 4 23
  4. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. (PMID: 8276421) Volz A. … Mischke D. (Genomics 1993) 2 3 23
  5. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. (PMID: 18838110) Tzang R.F. … Tsai S.J. (Neurosci. Lett. 2008) 3 23 49

Products for S100A10 Gene

Sources for S100A10 Gene

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