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S100A10 Gene

protein-coding   GIFtS: 63

GC01M150224
S100 calcium binding protein A10
(Previous names: S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)), S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ANX2LG, CAL1L)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
42C 1, 2
ANX2L 2
ANX2LG 2, 3
CAL1L 2, 3, 5
CLP11 1, 2, 3
Ca[1] 2
GP11 2
MGC111133 2
OTTHUMP00000015269 2
OTTHUMP00000015270 2
P11 1, 2
p10 2
p11 3
Descriptions
Calpactin I light chain 3
Calpactin-1 light chain 3
Cellular ligand of annexin II 3
S100 calcium binding protein A10 2
S100 calcium binding protein A10 (annexin II ligand,
calpactin I, light polypeptide (p11)) 1, 2
S100 calcium-binding protein A10 3
S100 calcium-binding protein A10 (annexin II ligand,
calpactin I, light polypeptide (p11)) 1, 2
annexin II ligand, calpactin I, light polypeptide 2
p10 protein 3
External Ids
HGNC: 104871
Entrez Gene: 62812
UniProtKB: P609033
Ensembl: ENSG000001977477
Search outside databases for aliases for S100A10 gene

Previous GC identifers: GC01M149796 GC01M147738 GC01M148730 GC01M149171 GC01M148768

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A10:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided
by RefSeq]

UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of
protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of
tyrosine-specific kinase

Gene Wiki entry for S100A10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A10 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150224:     (about GC identifiers)

Start:
150,222,010 bp from pter
End:
150,233,338 bp from pter
Size:
11,329 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 (See protein sequence)
Recommended Name: Protein S100-A10  
Size: 97 amino acids; 11203 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.
Interacts with SCN10A (By similarity)
Miscellaneous: Does not appear to bind calcium. Contains 2 ancestral calcium site related to
EF-hand domains that have lost their ability to bind calcium
PDB structure from and Proteopedia :
1A4P (3D)    1BT6 (3D)    
Secondary accessions: A8K4V8 P08206 Q5T1C5

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002957.1  

    ENSEMBL proteins: 
    ENSP00000357801 ENSP00000357799 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (S100A10)
    Human Recombinant Proteins from Abnova (S100A10)
                  OriGene Purified Recombinant Human Protein: S100A10 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739 mitochondrion IDA18029348
    About this table

    Antibodies for S100A10: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for S100A10
    R&D Systems Antibodies for S100A10
    Antibodies from Abcam (S100A10), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (S100A10)
    Novus Biologicals Antibodies for S100A10

    Assays for S100A10: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR011992 EF-Hand_type
     IPR013787 S100_Ca_bd_sub
     IPR001751 S100_Ca_bd


       GeneDecks  S100A10 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P60903

    ProtoNet protein and cluster: P60903

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
    Similarity: Belongs to the S-100 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A10)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002966

                  Applied Biosystems Silencer® siRNAs for S100A10

                  Sigma-Aldrich siRNA for S100A10  
                         Sigma-Aldrich shRNA for S100A10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for S100A10
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002966
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002966
                                     untagged cDNA clone in CMV expression vector: NM_002966 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002966

    UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
    Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of
    protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of
    tyrosine-specific kinase

    Genatlas biochemistry entry for S100A10:
    S100 calcium binding protein A10,epidermal differentiation complex

    4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S100a10):

    behavior/neurologicalhomeostasis/metabolismnervous systemtouch/vibrissae

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102 receptor binding NAS1831433
    GO:0005509 calcium ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  S100A10 


    5/20 Interacting proteins for S100A10 (ENSP000003577993 P609032) via UniProtKB, MINT, and/or STRING (see all 20 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12MINT-63928
    SETDB1Q150472MINT-63927
    ANXA2ENSP000003460323STRING (score=.998)
    PLGENSP000003089383STRING (score=.978)
    KCNK3ENSP000003062753STRING (score=.926)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction NAS1831433
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for S100A10
    5 Novoseek chemical compound relationships for S100A10 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 27.09 3 18065419 (1)
    arachidonic acid 20.91 10 12163506 (4), 11076800 (2), 12645529 (1)
    calcium 19.93 4 12645529 (1), 8682860 (1), 12163506 (1)
    tyrosine 14.69 10 12645529 (1), 15302870 (1), 1533380 (1), 1831433 (1) (see all 5)
    lysine 11.06 3 11939791 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (S100A10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (S100A10)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002966

                  Sigma-Aldrich siRNA for S100A10  
                         Sigma-Aldrich shRNA for S100A10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002966  

    REFSEQ mRNAs for S100A10 gene: 

    NM_002966.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002966  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002966
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002966
                                     untagged cDNA clone in CMV expression vector: NM_002966 

    Additional cDNA sequence: 

    AK291073.1 BC015973.1 BC105786.1 CR542162.1 CR610742.1 D28387.1 M38591.1 M81457.1 

    16 DOTS entries:

    DT.454560  DT.99982891  DT.100705295  DT.100803818  DT.121459339  DT.40208575  DT.421628  DT.40208585 
    DT.91951004  DT.121459332  DT.95261042  DT.100753245  DT.121459342  DT.121459360  DT.87078284  DT.95261112 

    24/552 AceView cDNA sequences (see all 552 ):

    CR610742 BU860855 AW273757 N92309 BQ953124 H28632 T94662 AI144406 
    BM541737 AI983171 AA376850 CB158822 AW328273 T62220 W93998 AA973779 
    BQ051331 BG926612 BM842132 BM672556 W17136 AA326781 AA733076 R12568 

    highest scoring ESTs for S100A10:

    AI201310 AA041412 AA299282 AA308139 AA313935 AA360215 AA369182 AA373194 AA385107 AA868542 

    Unigene Cluster for S100A10:

    S100 calcium binding protein A10
    Hs.143873  [show with all ESTs]
    Unigene Representative Sequence: CD388106


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000368811  ENST00000368809  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    S100A10 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for S100A10

    1 / 2 / 3

    3 probe-sets matching S100A10 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39338_at2, 3 U95-A 2 1.00 0.94 1.00 1.00 AI201310 1.00 1.00 1.00 1

    200872_at2, 3 U133-A 2 1.00 0.95 -- -- NM_002966 0.60 1.00 0.82 1

    200872_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  S100A10 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGCAGATCAG

    SOURCE GeneReport for Unigene cluster: Hs.143873

    Expression variation in blood from EXPOLDB for S100A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for S100A10 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    S100A101   -- S100 calcium binding protein A10 92.78(n)
    98.97(a)
    475851  XM_533060.2  XP_533060.2 
    chimpanzee
    (Pan troglodytes)
    LOC4573061   -- similar to calpactin I light chain 98.97(n)
    98.97(a)
    457306  XM_513807.2  XP_513807.2 
    cow
    (Bos taurus)
    S100A101   -- S100 calcium-binding protein A10 94.16(n)
    100(a)
    282466  NM_174650.1  NP_777075.1 
    rat
    (Rattus norvegicus)
    S100a101   -- S100 calcium binding protein A10 90.07(n)
    91.49(a)
    81778  NM_031114.1  NP_112376.1 
    mouse
    (Mus musculus)
    S100a101, 5 3 (41.70 cM)5
    S100 calcium binding protein A10 (calpactin)1, 5 89.69(n)1
    91.75(a)1
    201941  NM_009112.21  NP_033138.11 
     AA4099615  AK0511435  (see all 16)
    About this table        Species with no ortholog for S100A10

    ENSEMBL Gene Tree for S100A10
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for S100A10 gene
    S100A112  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/65 NCBI SNPs in S100A10 are shown (see all 65 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 78)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs30077081,2
    A,C,F,H150234460(+) GACTGT/GGTTTA 1 -- ng318Minor allele frequency- G:0.45EU EA WA NA 780
    rs13878351,2
    A,C,F,H150221516(-) GCAGTG/ACACTT 1 -- ng5113Minor allele frequency- A:0.12EA EU WA NA 1150
    rs65876401,2
    A,C,F,H150221854(+) GAAGTC/TAGACT 1 -- ng5116Minor allele frequency- T:0.38EU EA WA NS NA 1082
    rs13878341,2
    C,F,H,O150221676(-) ATCCAT/ATTTTC 1 -- ng5116Minor allele frequency- A:0.07NS EU EA WA NA 1086
    rs10387451,2
    C,F,H150233369(-) GGACTC/ACACGT 1 -- ng31 ese311Minor allele frequency- A:0.21EA MN EU WA 1200
    rs66786721,2
    C,F,H150221633(+) TGGTTC/TTCCTA 1 -- ng5116Minor allele frequency- T:0.29EU EA WA NS NA 1084
    --
    rs115420121,2
    H150222327(-) AATTGC/TGGGCC 1 A/V mis1 ese34Minor allele frequency- T:0.00EU EA WA 404
    rs23380191,2
    A,C,F,H150223438(+) TCCCAT/CATGAG 1 -- int14Minor allele frequency- C:0.46EU EA WA 418
    rs37911531,2
    A,C,F,H150224768(-) AAACCT/CGGTGG 1 -- int15Minor allele frequency- C:0.30EA EU WA 1912
    rs18733111,2
    A,C,F,H150228846(-) AGCTAA/GCAGTG 1 -- int111Minor allele frequency- G:0.07NA EA EU WA 1032
    About this table

    HapMap Linkage Disequilibrium images for S100A10 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 114085

    3 Novoseek disease relationships for S100A10 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.00 5 15574370 (3), 14570893 (2)
    tumors 0.00 5 18608216 (2), 17083565 (2)
    metastasis 0.00 4 15574370 (2), 18608216 (1), 17695432 (1)
    About this table

    1 PharmGKB disease relationship for S100A10 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Genome Epidemiology Navigator: S100A10 (3 documents)
    Tumor Gene Database: S100A10

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/84 PubMed articles for S100A10 gene (see all 84 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6281 HGNC: 10487 AceView: S100A10 Ensembl:ENSG00000197747 euGenes: HUgn6281
    ECgene: S100A10 H-InvDB: S100A10
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for S100A10 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for S100A10:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for S100A10 Antibodies for S100A10
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for S100A10 Browse small molecules at Sigma-Aldrich
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     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for S100A10




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for S100A10

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