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S100A10 Gene

protein-coding   GIFtS: 65
GCID: GC01M151955

S100 Calcium Binding Protein A10

(Previous names: S100 calcium-binding protein A10 (annexin II ligand, calpactin...)
(Previous symbols: ANX2LG, CAL1L)
  See S100A10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S100 Calcium Binding Protein A101 2     ANX2L2
CAL1L1 2 3 5     Ca[1]2
ANX2LG1 2 3     GP112
S100 Calcium Binding Protein A10 (Annexin II Ligand, Calpactin I, Light
Polypeptide (P11))1 2
     P112
S100 Calcium-Binding Protein A10 (Annexin II Ligand, Calpactin I, Light
Polypeptide (P11))1 2
     Annexin II Ligand, Calpactin I, Light Polypeptide2
Annexin II Tetramer (AIIt) P11 Subunit1 2     p102
Calpactin I Light Chain2 3     Protein S100-A102
Calpactin-1 Light Chain2 3     P10 Protein3
Cellular Ligand Of Annexin II2 3     p113
CLP112 3     S100 Calcium-Binding Protein A103
42C2     

External Ids:    HGNC: 104871   Entrez Gene: 62812   Ensembl: ENSG000001977477   OMIM: 1140855   UniProtKB: P609033   

Export aliases for S100A10 gene to outside databases

Previous GC identifers: GC01M149796 GC01M147738 GC01M148730 GC01M149171 GC01M148768 GC01M150224 GC01M123333


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for S100A10 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in
exocytosis and endocytosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100A10 Gene:
S100A10 (S100 calcium binding protein A10) is a protein-coding gene. Diseases associated with S100A10 include borna disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein
phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

Gene Wiki entry for S100A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the S100A10 gene promoter:
         Sox5   FOXF2   AML1a   ATF-2   Bach2   AP-4   E47   FOXO4   Hand1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A10 promoter sequence
   Search Chromatin IP Primers for S100A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat S100A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151955:  view genomic region     (about GC identifiers)

Start:
151,955,386 bp from pter      End:
151,966,866 bp from pter
Size:
11,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 (See protein sequence)
Recommended Name: Protein S100-A10  
Size: 97 amino acids; 11203 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with
SCN10A (By similarity)
Miscellaneous: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that
have lost their ability to bind calcium
Selected PDB 3D structures from and Proteopedia for S100A10 (see all 7):
1A4P (3D)        1BT6 (3D)        4DRW (3D)        4FTG (3D)        4HRE (3D)        4HRG (3D)    
Secondary accessions: A8K4V8 P08206 Q5T1C5

Explore the universe of human proteins at neXtProt for S100A10: NX_P60903

Explore proteomics data for S100A10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys37, Lys47, Lys54, Lys57
  • Modification sites at PhosphoSitePlus

  • See S100A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002957.1  
    ENSEMBL proteins: 
     ENSP00000357801   ENSP00000357799  

    S100A10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    S100: S100 calcium binding proteins

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR013787 S100_Ca-bd_sub
     IPR028476 S100-A10
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry P60903

    ProtoNet protein and cluster: P60903

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
    Similarity: Belongs to the S-100 family


    Find genes that share domains with S100A10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S10AA_HUMAN, P60903
    Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein
    phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

         Genatlas biochemistry entry for S100A10:
    S100 calcium binding protein A10,epidermal differentiation complex

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI14699089
    GO:0008289NOT lipid binding IDA--
    GO:0042803protein homodimerization activity IDA--
    GO:0044325ion channel binding IPI12198146
         
    Find genes that share ontologies with S100A10           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S100a10):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    Find genes that share phenotypes with S100A10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out S100a10tm1Pggd for S100A10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for S100A10
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S100A10

    miRNA
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    miRTarBase miRNAs that target S100A10:
    hsa-mir-100-5p (MIRT048454)

    Block miRNA regulation of human, mouse, rat S100A10 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate S100A10:
    hsa-miR-590-5p hsa-miR-767-3p hsa-miR-551b* hsa-miR-548c-3p hsa-miR-3616-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidS100A10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat S100A10

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    GenScript: all cDNA clones in your preferred vector: S100A10 (NM_002966)
    Sino Biological Human cDNA Clone for S100A10
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    plasma membrane2
    endosome1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019897extrinsic component of plasma membrane IEA--
    GO:0045121colocalizes with membrane raft IDA14699089
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with S100A10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for S100A10 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    2Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for S100A10
        Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for S100A10
        Prostaglandin Synthesis and Regulation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for S100A10
    Interactions:

        GeneGlobe Interaction Network for S100A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for S100A10 (P609031, 2, 3 ENSP000003577994) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-63928 I2D: score=4 
    SETDB1Q150472, 3MINT-63927 I2D: score=4 
    ANXA2P073553, ENSP000003460324I2D: score=3 STRING: ENSP00000346032
    KCNK3O146493, ENSP000003062754I2D: score=3 STRING: ENSP00000306275
    BADQ929343, ENSP000003091034I2D: score=2 STRING: ENSP00000309103
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001765membrane raft assembly IDA--
    GO:0006900membrane budding IDA--
    GO:0032855positive regulation of Rac GTPase activity IMP--
    GO:0051099positive regulation of binding IEA--
    GO:0051290protein heterotetramerization IDA--

    Find genes that share ontologies with S100A10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for S100A10 (S10AA)

    1 HMDB Compound for S100A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for S100A10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 34.8 10 12163506 (4), 11076800 (2), 12645529 (1)
    phospholipid 25.4 3 18065419 (1)
    calcium 21.7 4 12645529 (1), 8682860 (1), 12163506 (1)
    tyrosine 12.8 10 12645529 (1), 15302870 (1), 1533380 (1), 1831433 (1) (see all 5)
    lysine 9.08 3 11939791 (2)



    Find genes that share compounds with S100A10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for S100A10 gene: 
    NM_002966.2  

    Unigene Cluster for S100A10:

    S100 calcium binding protein A10
    Hs.143873  [show with all ESTs]
    Unigene Representative Sequence: CD388106
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368811(uc001ezl.3) ENST00000368809 ENST00000478574 ENST00000478348

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate S100A10:
    hsa-miR-590-5p hsa-miR-767-3p hsa-miR-551b* hsa-miR-548c-3p hsa-miR-3616-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidS100A10 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat S100A10
      QuantiTect SYBR Green Assays in human, mouse, rat S100A10
      QuantiFast Probe-based Assays in human, mouse, rat S100A10

    Additional mRNA sequence: 

    AK291073.1 BC015973.1 BC105786.1 CR542162.1 D28387.1 M38591.1 M81457.1 

    17 DOTS entries:

    DT.454560  DT.99982891  DT.100705295  DT.100803818  DT.121459339  DT.91951004  DT.40208585  DT.421628 
    DT.40208575  DT.121459332  DT.95261042  DT.100753245  DT.121459342  DT.121459360  DT.87078284  DT.95261112 
    DT.75138673 

    Selected AceView cDNA sequences (see all 552):

    AA360214 BE122797 AA360215 AW273757 AA326781 R12568 BQ948995 CB158189 
    BQ946137 BM855142 AA973779 T94311 CB117298 AA534434 AW183311 BG332809 
    CR610742 AI741498 AW338591 BX475621 N92309 CB109525 CB145425 BM852031 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    S100A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGATCAG
    S100A10 Expression
    About this image


    S100A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
    S100A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    S100A10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143873
        Custom PCR Arrays for S100A10
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    QuantiFast Probe-based Assays in human, mouse, rat S100A10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for S100A10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a101 , 5 S100 calcium binding protein A10 (calpactin)1, 5 89.69(n)1
    91.75(a)1
      3 (40.51 cM)5
    201941  NM_009112.21  NP_033138.11 
     935550805 
    chicken
    (Gallus gallus)
    Aves S100A101 S100 calcium binding protein A10 78.69(n)
    89.69(a)
      396506  NM_205506.1  NP_990837.1 
    lizard
    (Anolis carolinensis)
    Reptilia S100A106
    S100 calcium binding protein A10
    68(a)
    1 ↔ 1
    GL344049.1(38461-39863)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041295.12   -- 72.89(n)    BC041295.1 
    zebrafish
    (Danio rerio)
    Actinopterygii s100a10b1 S100 calcium binding protein A10b 57.39(n)
    52.58(a)
      406276  NM_213003.1  NP_998168.1 


    ENSEMBL Gene Tree for S100A10 (if available)
    TreeFam Gene Tree for S100A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for S100A10 gene
    S100A112  S100A62  S100A12  S100A122  S100B2  S100A42  S100A32  S100Z2  
    S100P2  S100A52  S100A22  S100A92  
    Selected SIMAP similar genes for S100A10 using alignment to 3 protein entries:     S10AA_HUMAN (see all proteins) (see all similar genes):
    S100Z    S100P    S100A11    S100A16    S100B    S100A1
    S100A4    S100A9    S100A2    S100A14    S100A12    S100A5
    S100A13    TCHH    HRNR    S100A7L2    S100A6    FLG2

    Find genes that share paralogs with S100A10           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for S100A10
    PGOHUM00000237107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for S100A10 (see all 260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13878351,2
    C,F,A,H--151954892(-) GCAGTG/ACACTT 1 -- ds500136Minor allele frequency- A:0.12EA NS NA WA CSA 3260
    rs741267631,2
    C,F--151954905(+) CGTGTA/GTAAGT 1 -- ds50012Minor allele frequency- G:0.04WA 120
    rs1499549131,2
    --151954950(+) ACTTAA/GTAGAT 1 -- ds50010--------
    rs66786721,2
    C,F,H--151955009(+) TGGTTC/TTCCTA 1 -- ds500133Minor allele frequency- T:0.27NS EA NA CSA WA 3017
    rs13878341,2
    C,F,O,H--151955052(-) ATCCAT/ATTTTC 1 -- ds500138Minor allele frequency- A:0.07NS EA NA WA CSA 3028
    rs1440851061,2
    --151955057(+) TTGGAC/TTCAGA 1 -- ds50010--------
    rs65876401,2
    C,F,A,H--151955230(+) GAAGTC/TAGACT 1 -- ds500135Minor allele frequency- T:0.39NS NA EA WA CSA 3013
    rs767874951,2
    C--151955279(+) TCTGTA/GAGAAA 1 -- ds50010--------
    rs1136742951,2
    C--151955279(+) CTGTG-/AGAAAAGCTC
    TGCTGTGTA
    /TA
    AGAAA
    1 -- ds50011CSA 2
    rs3681255431,2
    C--151955315(+) CTGTG-/TAAGA 
     AAAGCTC
    TGCTG
    2 -- ds5001 cds10--------

    HapMap Linkage Disequilibrium report for S100A10 (151955386 - 151966866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for S100A10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2855CNV Loss18451855
    nsv872441CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A10
    DNA2.0 Custom Variant and Variant Library Synthesis for S100A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114085    OMIM disorders: --

    1 disease for S100A10:    
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    borna disease

    1 disease from the University of Copenhagen DISEASES database for S100A10:
    Borna disease

    Find genes that share disorders with S100A10           About GenesLikeMe

    3 Novoseek inferred disease relationships for S100A10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 0 5 15574370 (2), 18608216 (1), 20085458 (1), 17695432 (1)
    tumors 0 5 18608216 (2), 17083565 (2)
    cancer 0 6 15574370 (3), 14570893 (2), 20085458 (1)

    Genetic Association Database (GAD): S100A10
    Human Genome Epidemiology (HuGE) Navigator: S100A10 (5 documents)
    Tumor Gene Database (TGDB): S100A10

    Export disorders for S100A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for S100A10 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with S100A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. (PubMed id 18838110)1, 4, 9 Tzang R.F....Tsai S.J. (Neurosci. Lett. 2008)
    2. Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II. (PubMed id 1831433)1, 2, 9 Kube E.... Gerke V. (Gene 1991)
    3. Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. (PubMed id 1533380)1, 2, 9 Harder T.... Gerke V. (Gene 1992)
    4. cDNA sequence of human p11 calpactin I light chain. (PubMed id 1386341)1, 2, 9 Dooley T.P.... Simon M. (Genomics 1992)
    5. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. (PubMed id 8276421)1, 3, 9 Volz A....Mischke D. (Genomics 1993)
    6. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    7. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
    8. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. (PubMed id 18288090)1, 4 Perlis R.H....Smoller J.W. (Neuropsychopharmacology 2008)
    9. Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression. (PubMed id 17510952)1, 4 Verma R....Potash J.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6281 HGNC: 10487 AceView: S100A10 Ensembl:ENSG00000197747 euGenes: HUgn6281
    ECgene: S100A10 H-InvDB: S100A10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for S100A10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for S100A10 gene:
    Search GeneIP for patents involving S100A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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