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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100A10 Gene

protein-coding   GIFtS: 64
GCID: GC01M151955

S100 Calcium Binding Protein A10

(Previous names: S100 calcium-binding protein A10 (annexin II ligand, calpactin...)
(Previous symbols: ANX2LG, CAL1L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
S100 Calcium Binding Protein A101 2     ANX2L2
CAL1L1 2 3 5     Ca[1]2
ANX2LG1 2 3     GP112
S100 Calcium Binding Protein A10 (Annexin II Ligand, Calpactin I, Light
Polypeptide (P11))1 2
     P112
S100 Calcium-Binding Protein A10 (Annexin II Ligand, Calpactin I, Light
Polypeptide (P11))1 2
     Annexin II Ligand, Calpactin I, Light Polypeptide2
Annexin II Tetramer (AIIt) P11 Subunit1 2     p102
Calpactin I Light Chain2 3     Protein S100-A102
Calpactin-1 Light Chain2 3     P10 Protein3
Cellular Ligand Of Annexin II2 3     p113
CLP112 3     S100 Calcium-Binding Protein A103
42C2     

External Ids:    HGNC: 104871   Entrez Gene: 62812   Ensembl: ENSG000001977477   OMIM: 1140855   UniProtKB: P609033   

Export aliases for S100A10 gene to outside databases

Previous GC identifers: GC01M149796 GC01M147738 GC01M148730 GC01M149171 GC01M148768 GC01M150224 GC01M123333


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S100A10 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in
exocytosis and endocytosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for S100A10 Gene: 
S100A10 (S100 calcium binding protein A10) is a protein-coding gene. Diseases associated with S100A10 include alcoholic hepatitis, and borna disease, and among its related super-pathways are wtCFTR and deltaF508 traffic / Membrane expression (norm and CF). GO annotations related to this gene include receptor binding and calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein
phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

Gene Wiki entry for S100A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100A10 gene promoter:
         Sox5   FOXF2   AML1a   ATF-2   Bach2   AP-4   E47   FOXO4   Hand1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for S100A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151955:  view genomic region     (about GC identifiers)

Start:
151,955,386 bp from pter      End:
151,966,866 bp from pter
Size:
11,481 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903 (See protein sequence)
Recommended Name: Protein S100-A10  
Size: 97 amino acids; 11203 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with
SCN10A (By similarity)
Miscellaneous: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that
have lost their ability to bind calcium
6/7 PDB 3D structures from and Proteopedia for S100A10 (see all 7):
1A4P (3D)        1BT6 (3D)        4DRW (3D)        4FTG (3D)        4HRE (3D)        4HRG (3D)    
Secondary accessions: A8K4V8 P08206 Q5T1C5

Explore the universe of human proteins at neXtProt for S100A10: NX_P60903

Explore proteomics data for S100A10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60903

  • S100A10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    S100A10 Protein Expression
    REFSEQ proteins: NP_002957.1  
    ENSEMBL proteins: 
     ENSP00000357801   ENSP00000357799  

    Human Recombinant Protein Products for S100A10: 
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    Cloud-Clone Corp. Proteins for S100A10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019897extrinsic to plasma membrane IEA--

    S100A10 for ontologies           About GeneDecksing



    S100A10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    S100: S100 calcium binding proteins

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR013787 S100_Ca-bd_sub
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry P60903

    ProtoNet protein and cluster: P60903

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10AA_HUMAN, P60903
    Similarity: Belongs to the S-100 family


    S100A10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S10AA_HUMAN, P60903
    Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein
    phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

         Genatlas biochemistry entry for S100A10:
    S100 calcium binding protein A10,epidermal differentiation complex

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005509calcium ion binding IEA--
         
    S100A10 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for S100a10):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    S100A10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out S100a10tm1Pggd for S100A10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for S100A10 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for S100A10 

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    SwitchGear 3'UTR luciferase reporter plasmidS100A10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for S100A10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Regulation of CFTR activity (norm and CF)0.38
    2Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for S100A10
        Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for S100A10
        Prostaglandin Synthesis and Regulation



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/20 Interacting proteins for S100A10 (P609032, 3 ENSP000003577994) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-63928 I2D: score=4 
    SETDB1Q150472, 3MINT-63927 I2D: score=4 
    ANXA2P073553, ENSP000003460324I2D: score=3 STRING: ENSP00000346032
    KCNK3O146493, ENSP000003062754I2D: score=3 STRING: ENSP00000306275
    BADQ929343, ENSP000003091034I2D: score=2 STRING: ENSP00000309103
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0051099positive regulation of binding IEA--
    GO:0071229cellular response to acid IEA--

    S100A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100A10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for S100A10 (S10AA)

    1 HMDB Compound for S100A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for S100A10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 34.8 10 12163506 (4), 11076800 (2), 12645529 (1)
    phospholipid 25.4 3 18065419 (1)
    calcium 21.7 4 12645529 (1), 8682860 (1), 12163506 (1)
    tyrosine 12.8 10 12645529 (1), 15302870 (1), 1533380 (1), 1831433 (1) (see all 5)
    lysine 9.08 3 11939791 (2)

    Search CenterWatch for drugs/clinical trials and news about S100A10 / S10AA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for S100A10 gene: 
    NM_002966.2  

    Unigene Cluster for S100A10:

    S100 calcium binding protein A10
    Hs.143873  [show with all ESTs]
    Unigene Representative Sequence: CD388106
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368811(uc001ezl.3) ENST00000368809 ENST00000478574 ENST00000478348

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate S100A10:
    hsa-miR-590-5p hsa-miR-767-3p hsa-miR-551b* hsa-miR-548c-3p hsa-miR-3616-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidS100A10 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat S100A10

    Additional mRNA sequence: 

    AK291073.1 BC015973.1 BC105786.1 CR542162.1 D28387.1 M38591.1 M81457.1 

    17 DOTS entries:

    DT.454560  DT.99982891  DT.100705295  DT.100803818  DT.121459339  DT.91951004  DT.40208585  DT.421628 
    DT.40208575  DT.121459332  DT.95261042  DT.100753245  DT.121459342  DT.121459360  DT.87078284  DT.95261112 
    DT.75138673 

    24/552 AceView cDNA sequences (see all 552):

    AI952041 AA326781 BM785208 BU521490 AA360214 BM672556 BQ948995 AI288655 
    AI217440 AI308932 BQ050753 AV705359 AI709267 AI633571 BM700204 BQ929540 
    D25647 AA733076 AI803597 AW328273 AA360215 AI587380 N92309 BQ073203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100A10 expression in normal human tissues (normalized intensities)      S100A10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGATCAG
    S100A10 Expression
    About this image


    S100A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 25 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             spinal/ganglion/dorsal root ganglion   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   

    See S100A10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100A10

    SOURCE GeneReport for Unigene cluster: Hs.143873
        SABiosciences Custom PCR Arrays for S100A10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for S100A10 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a101 , 5 S100 calcium binding protein A10 (calpactin)1, 5 89.69(n)1
    91.75(a)1
      3 (40.51 cM)5
    201941  NM_009112.21  NP_033138.11 
     935550805 
    chicken
    (Gallus gallus)
    Aves S100A101 S100 calcium binding protein A10 78.69(n)
    89.69(a)
      396506  NM_205506.1  NP_990837.1 
    lizard
    (Anolis carolinensis)
    Reptilia S100A106
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL344049.1(38461-39863)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041295.12   -- 72.89(n)    BC041295.1 
    zebrafish
    (Danio rerio)
    Actinopterygii s100a10b1 S100 calcium binding protein A10b 57.73(n)
    52.58(a)
      406276  NM_213003.1  NP_998168.1 


    ENSEMBL Gene Tree for S100A10 (if available)
    TreeFam Gene Tree for S100A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S100A10 gene
    S100A112  S100A62  S100A12  S100A122  S100B2  S100A42  S100A32  S100Z2  
    S100P2  S100A22  S100A52  S100A92  
    18/24 SIMAP similar genes for S100A10 using alignment to 3 protein entries:     S10AA_HUMAN (see all proteins) (see all similar genes):
    S100Z    S100P    S100A11    S100A16    S100B    S100A1
    S100A4    S100A9    S100A2    S100A14    S100A12    S100A5
    S100A13    TCHH    HRNR    S100A7L2    S100A6    FLG2

    S100A10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for S100A10
    PGOHUM00000237107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 SNPs in S100A10 are shown (see all 260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13878351,2
    C,F,A,H--151954892(-) GCAGTG/ACACTT 1 -- ds500136Minor allele frequency- A:0.12EA NS NA WA CSA 3260
    rs741267631,2
    C,F--151954905(+) CGTGTA/GTAAGT 1 -- ds50012Minor allele frequency- G:0.04WA 120
    rs1499549131,2
    --151954950(+) ACTTAA/GTAGAT 1 -- ds50010--------
    rs66786721,2
    C,F,H--151955009(+) TGGTTC/TTCCTA 1 -- ds500133Minor allele frequency- T:0.27NS EA NA CSA WA 3017
    rs13878341,2
    C,F,O,H--151955052(-) ATCCAT/ATTTTC 1 -- ds500138Minor allele frequency- A:0.07NS EA NA WA CSA 3028
    rs1440851061,2
    --151955057(+) TTGGAC/TTCAGA 1 -- ds50010--------
    rs65876401,2
    C,F,A,H--151955230(+) GAAGTC/TAGACT 1 -- ds500135Minor allele frequency- T:0.39NS NA EA WA CSA 3013
    rs767874951,2
    C--151955279(+) TCTGTA/GAGAAA 1 -- ds50010--------
    rs1136742951,2
    C--151955279(+) CTGTG-/AGAAAAGCTC
    TGCTGTGTA
    /TA
    AGAAA
    1 -- ds50011CSA 2
    rs3681255431,2
    C--151955315(+) CTGTG-/TAAGA 
     AAAGCTC
    TGCTG
    2 -- ds5001 cds10--------

    HapMap Linkage Disequilibrium report for S100A10 (151955386 - 151966866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for S100A10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2855CNV Loss18451855
    nsv872441CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114085    OMIM disorders: --

    20 diseases for S100A10:    About MalaCards
    alcoholic hepatitis    borna disease    irritable bowel syndrome    major depressive disorder
    barrett's adenocarcinoma    atopic dermatitis    alcoholism    dermatitis
    cystic fibrosis    renal cell carcinoma    liver disease    hypoxia
    bipolar disorder    endotheliitis    colorectal cancer    lung cancer
    thyroiditis    hepatitis    adenocarcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for S100A10:
    Borna disease

    S100A10 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for S100A10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 0 5 15574370 (2), 18608216 (1), 20085458 (1), 17695432 (1)
    tumors 0 5 18608216 (2), 17083565 (2)
    cancer 0 6 15574370 (3), 14570893 (2), 20085458 (1)

    Genetic Association Database (GAD): S100A10
    Human Genome Epidemiology (HuGE) Navigator: S100A10 (5 documents)
    Tumor Gene Database (TGDB): S100A10

    Export disorders for S100A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100A10 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with S100A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. (PubMed id 18838110)1, 4, 9 Tzang R.F....Tsai S.J. (2008)
    2. Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II. (PubMed id 1831433)1, 2, 9 Kube E.... Gerke V. (1991)
    3. Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. (PubMed id 1533380)1, 2, 9 Harder T.... Gerke V. (1992)
    4. cDNA sequence of human p11 calpactin I light chain. (PubMed id 1386341)1, 2, 9 Dooley T.P.... Simon M. (1992)
    5. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. (PubMed id 8276421)1, 3, 9 Volz A....Mischke D. (1993)
    6. Variation in genes of the epidermal differentiation c omplex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (2009)
    7. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    8. Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR(*)D Study. (PubMed id 18288090)1, 4 Perlis R.H....Smoller J.W. (2008)
    9. Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression. (PubMed id 17510952)1, 4 Verma R....Potash J.B. (2007)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6281 HGNC: 10487 AceView: S100A10 Ensembl:ENSG00000197747 euGenes: HUgn6281
    ECgene: S100A10 H-InvDB: S100A10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100A10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for S100A10 gene:
    Search GeneIP for patents involving S100A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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