Aliases for S100A1 Gene
External Ids for S100A1 Gene
Previous HGNC Symbols for S100A1 Gene
Previous GeneCards Identifiers for S100A1 Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
GeneCards Summary for S100A1 Gene
S100A1 (S100 Calcium Binding Protein A1) is a Protein Coding gene. Diseases associated with S100A1 include Malignant Peripheral Nerve Sheath Tumor and Orbital Leiomyoma. Among its related pathways are Activated TLR4 signalling and Innate Immune System. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100Z.
UniProtKB/Swiss-Prot for S100A1 Gene
Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).