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Aliases for S100A1 Gene

Aliases for S100A1 Gene

  • S100 Calcium Binding Protein A1 2 3 5
  • S100 Calcium-Binding Protein A1 2 3 4
  • S-100 Protein Subunit Alpha 3 4
  • S-100 Protein Alpha Chain 3 4
  • S100A 3 4
  • S100 Protein, Alpha Polypeptide 3
  • S100 Alpha 3
  • S100-Alpha 3
  • S100 3

External Ids for S100A1 Gene

Previous HGNC Symbols for S100A1 Gene

  • S100A

Previous GeneCards Identifiers for S100A1 Gene

  • GC01P151365
  • GC01P149331
  • GC01P150376
  • GC01P150817
  • GC01P150414
  • GC01P151867
  • GC01P153600
  • GC01P124964

Summaries for S100A1 Gene

Entrez Gene Summary for S100A1 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A1 Gene

S100A1 (S100 Calcium Binding Protein A1) is a Protein Coding gene. Diseases associated with S100A1 include Chondromyxoid Fibroma and Gastrointestinal Stromal Tumor. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A1 Gene

  • Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Gene Wiki entry for S100A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A1 Gene

Genomics for S100A1 Gene

Regulatory Elements for S100A1 Gene

Enhancers for S100A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around S100A1 on UCSC Golden Path with GeneCards custom track

Promoters for S100A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around S100A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for S100A1 Gene

Chromosome:
1
Start:
153,627,926 bp from pter
End:
153,632,039 bp from pter
Size:
4,114 bases
Orientation:
Plus strand

Genomic View for S100A1 Gene

Genes around S100A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A1 Gene

Proteins for S100A1 Gene

  • Protein details for S100A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23297-S10A1_HUMAN
    Recommended name:
    Protein S100-A1
    Protein Accession:
    P23297
    Secondary Accessions:
    • B2R5D9
    • Q5T7Y3

    Protein attributes for S100A1 Gene

    Size:
    94 amino acids
    Molecular mass:
    10546 Da
    Quaternary structure:
    • Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.

    Three dimensional structures from OCA and Proteopedia for S100A1 Gene

neXtProt entry for S100A1 Gene

Proteomics data for S100A1 Gene at MOPED

Post-translational modifications for S100A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A1 Gene

No data available for DME Specific Peptides for S100A1 Gene

Domains & Families for S100A1 Gene

Graphical View of Domain Structure for InterPro Entry

P23297

UniProtKB/Swiss-Prot:

S10A1_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the S-100 family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A1: view

Function for S100A1 Gene

Molecular function for S100A1 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A1,epidermal diffentiation complex
UniProtKB/Swiss-Prot Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Gene Ontology (GO) - Molecular Function for S100A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0048306 calcium-dependent protein binding IEA --
genes like me logo Genes that share ontologies with S100A1: view
genes like me logo Genes that share phenotypes with S100A1: view

Animal Models for S100A1 Gene

MGI Knock Outs for S100A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for S100A1

miRNA for S100A1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A1 Gene

Localization for S100A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A1 Gene COMPARTMENTS Subcellular localization image for S100A1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for S100A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016529 sarcoplasmic reticulum IDA 12804600
GO:0031672 A band IEA --
genes like me logo Genes that share ontologies with S100A1: view

Pathways & Interactions for S100A1 Gene

SuperPathways for S100A1 Gene

genes like me logo Genes that share pathways with S100A1: view

Pathways by source for S100A1 Gene

1 Cell Signaling Technology pathway for S100A1 Gene

Gene Ontology (GO) - Biological Process for S100A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008016 regulation of heart contraction IEA,NAS 12804600
genes like me logo Genes that share ontologies with S100A1: view

No data available for SIGNOR curated interactions for S100A1 Gene

Drugs & Compounds for S100A1 Gene

(14) Drugs for S100A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olopatadine Approved Pharma Target, antagonist 0
calcium Nutra 0

(13) Additional Compounds for S100A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A1: view

Transcripts for S100A1 Gene

Unigene Clusters for S100A1 Gene

S100 calcium binding protein A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A1 Gene

No ASD Table

Relevant External Links for S100A1 Gene

GeneLoc Exon Structure for
S100A1
ECgene alternative splicing isoforms for
S100A1

Expression for S100A1 Gene

mRNA expression in normal human tissues for S100A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for S100A1 Gene

This gene is overexpressed in Salivary gland (28.7), Spinal cord (15.1), and Tonsil (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A1 Gene



SOURCE GeneReport for Unigene cluster for S100A1 Gene Hs.515715

mRNA Expression by UniProt/SwissProt for S100A1 Gene

P23297-S10A1_HUMAN
Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
genes like me logo Genes that share expression patterns with S100A1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for S100A1 Gene

Orthologs for S100A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia S100A1 35
  • 93.62 (n)
  • 98.94 (a)
S100A1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A1 35
  • 92.91 (n)
  • 97.87 (a)
-- 36
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia S100a1 35
  • 87.59 (n)
  • 93.62 (a)
S100a1 16
S100a1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia S100A1 35
  • 100 (n)
  • 100 (a)
S100A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a1 35
  • 89.36 (n)
  • 93.62 (a)
oppossum
(Monodelphis domestica)
Mammalia S100A1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves S100A1 35
  • 82.62 (n)
  • 80.85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734724 35
  • 71.48 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii s100a1 35
  • 67.74 (n)
  • 72.04 (a)
s100a1 36
  • 70 (a)
ManyToMany
Species with no ortholog for S100A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A1 Gene

ENSEMBL:
Gene Tree for S100A1 (if available)
TreeFam:
Gene Tree for S100A1 (if available)

Paralogs for S100A1 Gene

(16) SIMAP similar genes for S100A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with S100A1: view

Variants for S100A1 Gene

Variation tolerance for S100A1 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for S100A1 Gene

Disorders for S100A1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for S100A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chondromyxoid fibroma
gastrointestinal stromal tumor
  • paraganglioma and gastric stromal sarcoma
leiomyosarcoma
  • leiomyosarcomas
malignant iris melanoma
  • malignant melanoma of iris
cellular schwannoma
  • cellular neurinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for S100A1

Genetic Association Database (GAD)
S100A1
Human Genome Epidemiology (HuGE) Navigator
S100A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
S100A1
genes like me logo Genes that share disorders with S100A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A1 Gene

Publications for S100A1 Gene

  1. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PMID: 20188096) Shimamoto S. … Kobayashi R. (FEBS Lett. 2010) 3 4 23 67
  2. Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. (PMID: 11944917) Okada M. … Kobayashi R. (Biochem. Biophys. Res. Commun. 2002) 23 25 26
  3. Immunohistochemical analysis of the S100A1, S100B, CD44 and Bcl-2 antigens and the rate of cell proliferation assessed by Ki-67 antibody in benign and malignant melanocytic tumours. (PMID: 20042890) Sviatoha V. … Skoog L. (Melanoma Res. 2010) 3 23
  4. Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins. (PMID: 20347987) Marlatt N.M. … Shaw G.S. (Protein Expr. Purif. 2010) 3 23
  5. S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma. (PMID: 19384190) Cossu-Rocca P. … Martignoni G. (Am. J. Surg. Pathol. 2009) 3 23

Products for S100A1 Gene

Sources for S100A1 Gene

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