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Aliases for S100A1 Gene

Aliases for S100A1 Gene

  • S100 Calcium Binding Protein A1 2 3
  • S100 Calcium-Binding Protein A1 2 3 4
  • S-100 Protein Subunit Alpha 3 4
  • S-100 Protein Alpha Chain 3 4
  • S100A 3 4
  • S100 Protein, Alpha Polypeptide 3
  • Protein S100-A1 3
  • S100 Alpha 3
  • S100-Alpha 3
  • S100 3

External Ids for S100A1 Gene

Previous Symbols for S100A1 Gene

  • S100A

Summaries for S100A1 Gene

Entrez Gene Summary for S100A1 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A1 Gene

S100A1 (S100 Calcium Binding Protein A1) is a Protein Coding gene. Diseases associated with S100A1 include primary malignant melanoma of the cervix and renal cell carcinoma. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A6.

UniProtKB/Swiss-Prot for S100A1 Gene

  • Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Gene Wiki entry for S100A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A1 Gene

Genomics for S100A1 Gene

Genomic Location for S100A1 Gene

Start:
153,627,926 bp from pter
End:
153,632,039 bp from pter
Size:
4,114 bases
Orientation:
Plus strand

Genomic View for S100A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for S100A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A1 Gene

Regulatory Elements for S100A1 Gene

Proteins for S100A1 Gene

  • Protein details for S100A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23297-S10A1_HUMAN
    Recommended name:
    Protein S100-A1
    Protein Accession:
    P23297
    Secondary Accessions:
    • B2R5D9
    • Q5T7Y3

    Protein attributes for S100A1 Gene

    Size:
    94 amino acids
    Molecular mass:
    10546 Da
    Quaternary structure:
    • Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.

    Three dimensional structures from OCA and Proteopedia for S100A1 Gene

neXtProt entry for S100A1 Gene

Proteomics data for S100A1 Gene at MOPED

Post-translational modifications for S100A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A1 Gene

No data available for DME Specific Peptides for S100A1 Gene

Domains for S100A1 Gene

Gene Families for S100A1 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • S100 :S100 calcium binding proteins

UniProtKB/Swiss-Prot:

S10A1_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • P23297
Family:
  • Belongs to the S-100 family.:
    • P23297
genes like me logo Genes that share domains with S100A1: view

Function for S100A1 Gene

Molecular function for S100A1 Gene

GENATLAS Biochemistry: S100 calcium binding protein A1,epidermal diffentiation complex
UniProtKB/Swiss-Prot Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Gene Ontology (GO) - Molecular Function for S100A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10913138
GO:0042802 identical protein binding IPI 10913138
GO:0042803 protein homodimerization activity IDA 10913138
GO:0044548 S100 protein binding IPI 10913138
genes like me logo Genes that share ontologies with S100A1: view
genes like me logo Genes that share phenotypes with S100A1: view

Animal Models for S100A1 Gene

MGI Knock Outs for S100A1:

miRNA for S100A1 Gene

miRTarBase miRNAs that target S100A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for S100A1 Gene

Localization for S100A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for S100A1 Gene COMPARTMENTS Subcellular localization image for S100A1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for S100A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12118070
GO:0005737 cytoplasm --
GO:0016529 sarcoplasmic reticulum IDA 12804600
GO:0030018 Z disc IEA --
GO:0031430 M band IEA --
genes like me logo Genes that share ontologies with S100A1: view

Pathways for S100A1 Gene

SuperPathways for S100A1 Gene

genes like me logo Genes that share pathways with S100A1: view

Pathways by source for S100A1 Gene

1 Cell Signaling Technology pathway for S100A1 Gene

Gene Ontology (GO) - Biological Process for S100A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0008016 regulation of heart contraction NAS 12804600
GO:0021762 substantia nigra development IEP 22926577
GO:0035556 intracellular signal transduction NAS 12804600
GO:1901387 positive regulation of voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with S100A1: view

Compounds for S100A1 Gene

(1) HMDB Compounds for S100A1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for S100A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Olopatadine
113806-05-6 target antagonist

(26) Novoseek inferred chemical compound relationships for S100A1 Gene

Compound -log(P) Hits PubMed IDs
mucicarmine 52.6 2
hematoxylin 40.3 3
progesterone 39.9 19
glycogen 38.8 2
paraffin 35.3 6
genes like me logo Genes that share compounds with S100A1: view

Transcripts for S100A1 Gene

Unigene Clusters for S100A1 Gene

S100 calcium binding protein A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for S100A1 Gene

No ASD Table

Relevant External Links for S100A1 Gene

GeneLoc Exon Structure for
S100A1
ECgene alternative splicing isoforms for
S100A1

Expression for S100A1 Gene

mRNA expression in normal human tissues for S100A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for S100A1 Gene

SOURCE GeneReport for Unigene cluster for S100A1 Gene Hs.515715

mRNA Expression by UniProt/SwissProt for S100A1 Gene

P23297-S10A1_HUMAN
Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain
genes like me logo Genes that share expressions with S100A1: view

Orthologs for S100A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A1 36
  • 100 (n)
  • 100 (a)
S100A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia S100A1 36
  • 93.62 (n)
  • 98.94 (a)
S100A1 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 43 (a)
ManyToMany
S100A1 36
  • 92.91 (n)
  • 97.87 (a)
mouse
(Mus musculus)
Mammalia S100a1 36
  • 87.59 (n)
  • 93.62 (a)
S100a1 16
S100a1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A1 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia S100a1 36
  • 89.36 (n)
  • 93.62 (a)
chicken
(Gallus gallus)
Aves S100A1 36
  • 82.62 (n)
  • 80.85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734724 36
  • 71.48 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii s100a1 36
  • 67.74 (n)
  • 72.04 (a)
s100a1 37
  • 70 (a)
ManyToMany
Species with no ortholog for S100A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A1 Gene

ENSEMBL:
Gene Tree for S100A1 (if available)
TreeFam:
Gene Tree for S100A1 (if available)

Paralogs for S100A1 Gene

Selected SIMAP similar genes for S100A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with S100A1: view

Variants for S100A1 Gene

Relevant External Links for S100A1 Gene

HapMap Linkage Disequilibrium report
S100A1

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for S100A1 Gene

Disorders for S100A1 Gene

(3) University of Copenhagen DISEASES for S100A1 Gene

(93) Novoseek inferred disease relationships for S100A1 Gene

Disease -log(P) Hits PubMed IDs
myoepithelioma 81.4 3
gastrointestinal stromal tumor 80.3 2
stromal tumors 78.6 2
smooth muscle tumor 75.7 3
tumors 72.2 114

Relevant External Links for S100A1

Genetic Association Database (GAD)
S100A1
Human Genome Epidemiology (HuGE) Navigator
S100A1
genes like me logo Genes that share disorders with S100A1: view

No data available for UniProtKB/Swiss-Prot for S100A1 Gene

Publications for S100A1 Gene

  1. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PMID: 20188096) Shimamoto S. … Kobayashi R. (FEBS Lett. 2010) 3 4 23
  2. Immunohistochemical analysis of the S100A1, S100B, CD44 and Bcl-2 antigens and the rate of cell proliferation assessed by Ki-67 antibody in benign and malignant melanocytic tumours. (PMID: 20042890) Sviatoha V. … Skoog L. (Melanoma Res. 2010) 3 23
  3. S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma. (PMID: 19384190) Cossu-Rocca P. … Martignoni G. (Am. J. Surg. Pathol. 2009) 3 23
  4. S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. (PMID: 19538970) Kraus C. … Most P. (J. Mol. Cell. Cardiol. 2009) 3 23
  5. S100A1 and calmodulin compete for the same binding site on ryanodine receptor. (PMID: 18650434) Wright N.T. … Weber D.J. (J. Biol. Chem. 2008) 4 23

Products for S100A1 Gene

Sources for S100A1 Gene

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