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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100A1 Gene

protein-coding   GIFtS: 60
GCID: GC01P153600

S100 Calcium Binding Protein A1

(Previous name: S100 calcium-binding protein A1)
(Previous symbol: S100A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
S100 Calcium Binding Protein A11 2     S1002
S100A1 2 3     S100-alpha2
S100 Calcium-Binding Protein A11 2 3     Protein S100-A12
S-100 Protein Alpha Chain2 3     S100 Alpha2
S-100 Protein Subunit Alpha2 3     S100 Protein, Alpha Polypeptide2

External Ids:    HGNC: 104861   Entrez Gene: 62712   Ensembl: ENSG000001606787   OMIM: 1769405   UniProtKB: P232973   

Export aliases for S100A1 gene to outside databases

Previous GC identifers: GC01P151365 GC01P149331 GC01P150376 GC01P150817 GC01P150414 GC01P151867 GC01P124964


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for S100A1 Gene:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes
include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in
stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase
C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. (provided
by RefSeq, Jul 2008)

GeneCards Summary for S100A1 Gene: 
S100A1 (S100 calcium binding protein A1) is a protein-coding gene. Diseases associated with S100A1 include primary malignant melanoma of the cervix, and retroperitoneal leiomyosarcoma. GO annotations related to this gene include identical protein binding and calcium ion binding. An important paralog of this gene is S100A11.

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist
for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both
divalent cations, especially affecting high-affinity calcium-binding sites

Gene Wiki entry for S100A1 (S100 calcium-binding protein A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100A1 gene promoter:
         Brachyury   MyoD   FOXD1   MIF-1   AREB6   CREB   deltaCREB   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidS100A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for S100A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153600:  view genomic region     (about GC identifiers)

Start:
153,600,402 bp from pter      End:
153,604,513 bp from pter
Size:
4,112 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297 (See protein sequence)
Recommended Name: Protein S100-A1  
Size: 94 amino acids; 10546 Da
Subunit: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms
heterodimers with S100P. Interacts with AGER and CAPZA1 (By similarity). Interacts with FKBP4. Interacts with
RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner
Subcellular location: Cytoplasm
6/7 PDB 3D structures from and Proteopedia for S100A1 (see all 7):
2L0P (3D)        2LHL (3D)        2LLS (3D)        2LLT (3D)        2LLU (3D)        2LP2 (3D)    
Secondary accessions: B2R5D9 Q5T7Y3

Explore the universe of human proteins at neXtProt for S100A1: NX_P23297

Explore proteomics data for S100A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23297

  • S100A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    S100A1 Protein Expression
    REFSEQ proteins: NP_006262.1  
    ENSEMBL proteins: 
     ENSP00000357687   ENSP00000292169   ENSP00000357685   ENSP00000389708  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12118070
    GO:0016529sarcoplasmic reticulum IDA12804600
    GO:0043234protein complex NAS14638689

    S100A1 for ontologies           About GeneDecksing



    S100A1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    S100: S100 calcium binding proteins

    5 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry P23297

    ProtoNet protein and cluster: P23297

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    S100A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S10A1_HUMAN, P23297
    Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist
    for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both
    divalent cations, especially affecting high-affinity calcium-binding sites

         Genatlas biochemistry entry for S100A1:
    S100 calcium binding protein A1,epidermal diffentiation complex

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10913138
    GO:0042802identical protein binding IPI10913138
    GO:0042803protein homodimerization activity IDA10913138
    GO:0044548S100 protein binding IPI10913138
         
    S100A1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for S100A1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory  Increased number of cells in m  Wnt reporter downregulated 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for S100a1):
     behavior/neurological  cardiovascular system  muscle  normal 

    S100A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out S100a1tm1Jhh for S100A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for S100A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for S100A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for S100A1 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for S100A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1"Ca, cAMP and Lipid Signaling"
    "Ca, cAMP and Lipid Signaling"

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for S100A1
        Ca, cAMP and Lipid Signaling




    S100A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/34 Interacting proteins for S100A1 (P232971, 2, 3 ENSP000002921694) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-7905063 MINT-7905229 I2D: score=2 STRING: ENSP00000417281
    TP53P046372, 3, ENSP000002693054MINT-7905174 MINT-7905308 I2D: score=1 STRING: ENSP00000269305
    AGERQ151093, ENSP000003642174I2D: score=1 STRING: ENSP00000364217
    ENSG00000206320Q151093I2D: score=1 
    ENSG00000229058Q151093I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0008016regulation of heart contraction NAS12804600
    GO:0035556intracellular signal transduction NAS12804600

    S100A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for S100A1 (S10A1)

    1 HMDB Compound for S100A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for S100A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olopatadine-- 113806-05-6targetantagonist11944917

    10/26 Novoseek inferred chemical compound relationships for S100A1 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mucicarmine 52.6 2 8776426 (1), 19596664 (1)
    hematoxylin 40.3 3 15807305 (1), 2012790 (1), 20002980 (1)
    progesterone 39.9 20 12883239 (1), 15807314 (1), 16160476 (1), 9648158 (1) (see all 19)
    glycogen 38.8 2 8370068 (2)
    paraffin 35.3 6 2239828 (1), 8835184 (1), 9857244 (1), 16424536 (1) (see all 6)
    b 723 34.6 2 12647218 (1), 9777982 (1)
    calcium 33.9 98 18384084 (6), 9562557 (5), 8894274 (4), 15885104 (4) (see all 41)
    estrogen 33.3 21 12883239 (1), 16160476 (1), 9648158 (1), 10365857 (1) (see all 20)
    ferric oxide 31.7 2 10491956 (1), 14703110 (1)
    toluidine 25.1 2 2012790 (1), 19724881 (1)

    Search CenterWatch for drugs/clinical trials and news about S100A1 / S10A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for S100A1 gene: 
    NM_006271.1  

    Unigene Cluster for S100A1:

    S100 calcium binding protein A1
    Hs.515715  [show with all ESTs]
    Unigene Representative Sequence: BM472825
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368698 ENST00000469893 ENST00000292169(uc001fck.1 uc001fcl.1)
    ENST00000368696 ENST00000436839
    miRNA
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    Additional mRNA sequence: 

    AB451316.1 AB451446.1 AK312152.1 BC014392.1 BC072006.1 BC094843.1 BT006938.1 X58079.1 

    14 DOTS entries:

    DT.97861882  DT.86821086  DT.95154778  DT.100032143  DT.121412413  DT.102840744  DT.92429590  DT.92429603 
    DT.121412367  DT.92429605  DT.95318019  DT.91940742  DT.97791395  DT.97864090 

    24/185 AceView cDNA sequences (see all 185):

    F35232 BM727863 BG576755 AA330750 BM694862 AA211609 X58079 BE612852 
    BQ186679 BM716207 H22491 BM719637 BM711668 AI300836 BM717929 H41365 
    BM702456 BE902396 BM704736 AI352680 BM694560 AL120020 BM723401 NM_006271 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100A1 expression in normal human tissues (normalized intensities)      S100A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    S100A1 Expression
    About this image


    S100A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Extraocular Muscles
             skeletal muscle ; myocytes   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Adipose-derived spheroid cells
             breast ; adipocytes   

    See S100A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100A1

    SOURCE GeneReport for Unigene cluster: Hs.515715

    UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
    Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for S100A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for S100A1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia S100a11 , 5 S100 calcium binding protein A11, 5 87.59(n)1
    93.62(a)1
      3 (39.24 cM)5
    201931  NM_011309.31  NP_035439.11 
     905110345 
    chicken
    (Gallus gallus)
    Aves LOC1008582581 protein S100-A1-like 82.62(n)
    80.85(a)
      100858258  XM_003642629.1  XP_003642677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570707272   -- 76.06(n)    57070727 


    ENSEMBL Gene Tree for S100A1 (if available)
    TreeFam Gene Tree for S100A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S100A1 gene
    S100A112  S100A62  S100A122  S100B2  S100A42  S100A32  S100A102  S100Z2  
    S100P2  S100A22  S100A52  S100A92  
    16 SIMAP similar genes for S100A1 using alignment to 4 protein entries:     S10A1_HUMAN (see all proteins):
    S100B    S100A4    S100Z    S100P    S100A11    S100A2
    S100A5    S100A6    RPTN    S100A9    S100G    S100A10
    S100A12    S100A3    SNTN    S100A8

    S100A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing S100A1
    DNA2.0 Custom Variant and Variant Library Synthesis for S100A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176940    OMIM disorders: --

    20/135 diseases for S100A1 (see all 135):    About MalaCards
    primary malignant melanoma of the cervix    retroperitoneal leiomyosarcoma    chondroid chordoma    ossifying fibromyxoid tumor
    glomangioma    spindle cell lipoma    cellular schwannoma    spiradenoma
    mucoepidermoid carcinoma    myoepithelial carcinoma    amelanotic melanoma    sarcomatoid mesothelioma
    rosai-dorfman disease    oxyphilic adenoma    nephrogenic adenoma    sarcomatoid renal cell carcinoma
    polymorphous low-grade adenocarcinoma    gastrointestinal stromal tumor    inflammatory myofibroblastic tumor    chondroblastoma

    3 diseases from the University of Copenhagen DISEASES database for S100A1:
    Renal oncocytoma     Oxyphilic adenoma     Nephrogenic adenoma

    S100A1 for disorders           About GeneDecksing

    10/93 Novoseek inferred disease relationships for S100A1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myoepithelioma 81.4 3 15619979 (1), 15717758 (1), 16099771 (1)
    gastrointestinal stromal tumor 80.3 2 19108033 (1), 16892012 (1)
    stromal tumors 78.6 2 2192100 (1), 15223969 (1)
    smooth muscle tumor 75.7 3 16400320 (1), 18505417 (1), 15796874 (1)
    tumors 72.2 243 16422363 (3), 1612579 (3), 7693778 (3), 1803052 (2) (see all 99)
    leiomyosarcoma 71.6 4 18505417 (1), 14633453 (1), 15796874 (1), 18250540 (1)
    neurothekeoma 68.4 2 10891717 (1)
    peripheral nerve sheath tumors 65.8 1 16316954 (1)
    malignant peripheral nerve sheath tumors 64.4 1 19154261 (1)
    leiomyoma 63.7 6 18505417 (1), 14633453 (1), 16422363 (1), 18425046 (1) (see all 6)

    Genetic Association Database (GAD): S100A1
    Human Genome Epidemiology (HuGE) Navigator: S100A1 (3 documents)

    Export disorders for S100A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100A1 gene, integrated from 9 sources (see all 649):
    (articles sorted by number of sources associating them with S100A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PubMed id 20188096)1, 2, 9 Shimamoto S....Kobayashi R. (2010)
    2. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. (PubMed id 12042313)1, 2, 9 Filipek A....Kuznicki J. (2002)
    3. Post-translational S-nitrosylation is an endogenous factor fine tuning the properties of human S100A1 protein. (PubMed id 22989881)1, 2 Lenarcic Zivkovic M.... Wyslouch-Cieszynska A. (2012)
    4. Solution NMR structure and dynamics of human apo-S100A1 protein. (PubMed id 21296671)1, 2 Nowakowski M.... Ejchart A. (2011)
    5. Variation in genes of the epidermal differentiation c omplex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (2009)
    6. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients. (PubMed id 17512776)1, 4 Kuo H.W....Chen D.J. (2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Heterodimeric interaction and interfaces of S100A1 an d S100P. (PubMed id 15171681)1, 2 Wang G....Barraclough R. (2004)
    10. S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. (PubMed id 1384693)1, 2 Engelkamp D.... Heizmann C.W. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6271 HGNC: 10486 AceView: S100A1 Ensembl:ENSG00000160678 euGenes: HUgn6271
    ECgene: S100A1 H-InvDB: S100A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for S100A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for S100A1 gene:
    Search GeneIP for patents involving S100A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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