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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

S100A1 Gene

protein-coding   GIFtS: 61
GCID: GC01P153600

S100 calcium binding protein A1

(Previous name: S100 calcium-binding protein A1 )
(Previous symbol: S100A)
 Explore 149 diseases affiliated with
S100A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for S100A1    

Aliases
for S100A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
S100 Calcium Binding Protein A11 2     S-100 Protein Subunit Alpha2 3
S100A1 2 3     S1002
S100 Calcium-Binding Protein A11 2 3     Protein S100-A12
S100-Alpha1     S100 Alpha2
S-100 Protein Alpha Chain2 3     S100 Protein, Alpha Polypeptide2

External Ids:    HGNC: 104861   Entrez Gene: 62712   Ensembl: ENSG000001606787   OMIM: 1769405   UniProtKB: P232973   

Export aliases for S100A1 gene to outside databases

Previous GC identifers: GC01P151365 GC01P149331 GC01P150376 GC01P150817 GC01P150414 GC01P151867 GC01P124964


Summaries
for S100A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for S100A1:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding
motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the
regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at
least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of
Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated
phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for
both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent
cations, especially affecting high-affinity calcium-binding sites

Gene Wiki entry for S100A1 (S100 calcium-binding protein A1)


Genomic Views
for S100A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the S100A1 gene promoter:
         Brachyury   MyoD   FOXD1   MIF-1   AREB6   CREB   deltaCREB   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: S100A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for S100A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat S100A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
S100A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153600:  view genomic region     (about GC identifiers)

Start:
 153,600,402 bp from pter      End:
 153,604,513 bp from pter
Size:
 4,112 bases      Orientation:
 plus strand

Proteins
for S100A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297 (See protein sequence)
Recommended Name: Protein S100-A1  
Size: 94 amino acids; 10546 Da
Subunit: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers
with S100P. Interacts with AGER and CAPZA1 (By similarity). Interacts with FKBP4. Interacts with RYR1 and RYR2.
Interacts with CACYBP in a calcium-dependent manner
Subcellular location: Cytoplasm
5 PDB 3D structures from and Proteopedia for S100A1:
2L0P (3D)        2LHL (3D)        2LLS (3D)        2LLT (3D)        2LLU (3D)    
Secondary accessions: B2R5D9 Q5T7Y3

Explore the universe of human proteins at neXtProt for S100A1: NX_P23297

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23297

    • S100A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006262.1  
    ENSEMBL proteins: 
     ENSP00000357687   ENSP00000292169   ENSP00000357685   ENSP00000389708  

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    ProSpec Recombinant Protein for S100A1
    Uscn Proteins for S100A1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA12118070
    GO:0005737cytoplasm ----
    GO:0016529sarcoplasmic reticulum IDA12804600
    GO:0043234protein complex NAS14638689


    S100A1 for ontologies           About GeneDecksing



    S100A1 Antibody Products: 
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    Uscn ELISAs and CLIAs for S100A1

    Protein Domains /
    Families
    for S100A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    S100A1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018248 EF-hand
     IPR013787 S100_Ca-bd_sub

    Graphical View of Domain Structure for InterPro Entry P23297

    ProtoNet protein and cluster: P23297

    1 Blocks protein family: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
    Similarity: Belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Function
    for S100A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
    Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for
    both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent
    cations, especially affecting high-affinity calcium-binding sites

         Genatlas biochemistry entry for S100A1:
    S100 calcium binding protein A1,epidermal diffentiation complex

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding IPI--
    GO:0042803protein homodimerization activity IDA10913138
    GO:0044548S100 protein binding IPI10913138


    S100A1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for S100A1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory  Increased number of cells in m  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-out S100a1tm1Jhh for S100A1
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for S100a1):
     behavior/neurological  cardiovascular system  muscle  normal 

    S100A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for S100A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for S100A1
        Ca, cAMP and Lipid Signaling



    S100A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for S100A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/28 Interacting proteins for S100A1 (P232971, 2, 3 ENSP000002921694) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-7905063 MINT-7905229 I2D: score=2 STRING: ENSP00000417281
    TP53P046372, 3, ENSP000002693054MINT-7905174 MINT-7905308 I2D: score=1 STRING: ENSP00000269305
    S100BP042711, 3, ENSP000002917004EBI-743686,EBI-458391 I2D: score=6 STRING: ENSP00000291700
    S100PP258151, 3, ENSP000002963704EBI-743686,EBI-743700 I2D: score=4 STRING: ENSP00000296370
    S100A4P264473, ENSP000003462944I2D: score=6 STRING: ENSP00000346294
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0008016regulation of heart contraction NAS12804600
    GO:0035556intracellular signal transduction NAS12804600


    S100A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for S100A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    S100A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for S100A1

    1 HMDB Compound for S100A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for S100A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olopatadine-- 113806-05-6targetantagonist11944917

    10/26 Novoseek chemical compound relationships for S100A1 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mucicarmine 52.6 2 8776426 (1), 19596664 (1)
    hematoxylin 40.3 3 15807305 (1), 2012790 (1), 20002980 (1)
    progesterone 39.9 20 12883239 (1), 15807314 (1), 16160476 (1), 9648158 (1) (see all 19)
    glycogen 38.8 2 8370068 (2)
    paraffin 35.3 6 2239828 (1), 8835184 (1), 9857244 (1), 16424536 (1) (see all 6)
    b 723 34.6 2 12647218 (1), 9777982 (1)
    calcium 33.9 98 18384084 (6), 9562557 (5), 8894274 (4), 15885104 (4) (see all 41)
    estrogen 33.3 21 12883239 (1), 16160476 (1), 9648158 (1), 10365857 (1) (see all 20)
    ferric oxide 31.7 2 10491956 (1), 14703110 (1)
    toluidine 25.1 2 2012790 (1), 19724881 (1)

    Search CenterWatch for drugs/clinical trials and news about S100A1 / S10A1 

    Transcripts
    for S100A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for S100A1 gene: 
    NM_006271.1  

    Unigene Cluster for S100A1:

    S100 calcium binding protein A1
    Hs.515715  [show with all ESTs]
    Unigene Representative Sequence: BM472825
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368698 ENST00000469893 ENST00000292169(uc001fck.1 uc001fcl.1)
    ENST00000368696 ENST00000436839

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB451316.1 AB451446.1 AK312152.1 BC014392.1 BC072006.1 BC094843.1 BT006938.1 X58079.1 

    14 DOTS entries:

    DT.97861882  DT.86821086  DT.95154778  DT.100032143  DT.121412413  DT.102840744  DT.92429590  DT.92429603 
    DT.121412367  DT.92429605  DT.95318019  DT.91940742  DT.97791395  DT.97864090 

    24/185 AceView cDNA sequences (see all 185):

    BM723401 AA330750 BM711668 BE900737 BM704736 AI625362 NM_006271 BM702456 
    X58079 H22491 AI300836 H41365 BM727863 AA211609 BM716207 BE902396 
    BG576755 BE612852 AI352680 F35232 BM719637 BQ186679 BM717929 AL120020 

    GeneLoc Exon Structure


    Expression
    for S100A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    S100A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    S100A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See S100A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for S100A1

    SOURCE GeneReport for Unigene cluster: Hs.515715

    UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
    Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain

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    In Situ
    Assay Products:     
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    Orthologs
    for S100A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for S100A1 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008582581 protein S100-A1-like 82.62(n)
    80.85(a)    		   100858258  XM_003642629.1  XP_003642677.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570707272   -- 76.06(n)    57070727 


    ENSEMBL Gene Tree for S100A1 (if available)
    TreeFam Gene Tree for S100A1 (if available) 

    Paralogs
    for S100A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for S100A1 gene
    S100A112  S100A62  S100A122  S100A82  S100B2  S100A42  S100A32  S100A102  
    S100Z2  S100A22  S100P2  S100A52  S100A92  
    16 SIMAP similar genes for S100A1 using alignment to 4 protein entries:     S10A1_HUMAN (see all proteins):
    S100B    S100A4    S100Z    S100P    S100A11    S100A5
    S100A6    RPTN    S100A9    S100G    S100A10    S100A12
    S100A3    SNTN    S100A8    S100A2

    S100A1 for paralogs           About GeneDecksing



    Genomic Variants
    for S100A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 NCBI SNPs in S100A1 are shown (see all 110)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs730099981,2
    		C,--124968063(+) GAGACG/ATGAAG 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs287096121,2
    		C--124968147(+) CTACTT/CGAGGA 3 -- us2k12Minor allele frequency- C:0.00NA 4
    rs561045871,2
    		--124968444(+) CAGACA/GGGGTT 3 -- us2k10--------
    rs1498436561,2
    		--153599002(+) TGTCAA/GGGCTG 6 -- us2k1 ut510--------
    rs1458666961,2
    		--153599009(+) GCTGAC/TCTGTG 6 -- us2k1 ut510--------
    rs1859302471,2
    		--153599027(+) GAAGGA/CGCAGA 6 -- int1 us2k10--------
    rs115518141,2
    		C--153599171(+) TGACCA/CGGCAA 6 -- int1 us2k12Minor allele frequency- C:0.00NA 4
    rs1908523361,2
    		--153599373(+) GGTGGC/TCCCTC 6 -- int1 us2k10--------
    rs1818010261,2
    		--153599384(+) TGTGGC/TGTGTC 6 -- int1 us2k10--------
    rs1394094521,2
    		--153599386(+) TGGCGC/TGTCTG 6 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for S100A1 (153600402 - 153604513 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for S100A1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for S100A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    S100A1 for disorders           About GeneDecksing

    OMIM gene information: 176940    OMIM disorders: --

    20/149 diseases for S100A1 (see all 149):    About MalaCards
    malignant peripheral nerve sheath tumor    polymorphous low-grade adenocarcinoma    rosai-dorfman disease    dermatofibrosarcoma protuberans
    alveolar soft part sarcoma    malignant fibrous histiocytoma    smooth muscle tumor    fibrous histiocytoma
    extraskeletal myxoid chondrosarcoma    cardiomyopathy    ossifying fibromyxoid tumor    langerhans-cell histiocytosis
    sudden infant death syndrome    perivascular epithelioid cell tumor    gastrointestinal stromal tumor    myxoid chondrosarcoma
    cellular schwannoma    chondroid chordoma    renal clear cell carcinoma    papillary serous carcinoma of the peritoneum

    3 diseases from the University of Copenhagen DISEASES database for S100A1:
    Renal oncocytoma     Oxyphilic adenoma     Nephrogenic adenoma

    10/93 Novoseek disease relationships for S100A1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myoepithelioma 81.4 3 15619979 (1), 15717758 (1), 16099771 (1)
    gastrointestinal stromal tumor 80.3 2 19108033 (1), 16892012 (1)
    stromal tumors 78.6 2 2192100 (1), 15223969 (1)
    smooth muscle tumor 75.7 3 16400320 (1), 18505417 (1), 15796874 (1)
    tumors 72.2 243 16422363 (3), 1612579 (3), 7693778 (3), 1803052 (2) (see all 99)
    leiomyosarcoma 71.6 4 18505417 (1), 14633453 (1), 15796874 (1), 18250540 (1)
    neurothekeoma 68.4 2 10891717 (1)
    peripheral nerve sheath tumors 65.8 1 16316954 (1)
    malignant peripheral nerve sheath tumors 64.4 1 19154261 (1)
    leiomyoma 63.7 6 18505417 (1), 14633453 (1), 16422363 (1), 18425046 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: S100A1 (3 documents)

    Export disorders for S100A1 gene to outside databases

    Publications
    for S100A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for S100A1 gene, integrated from 9 sources (see all 645):
    (articles sorted by number of sources associating them with S100A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. (PubMed id 12042313)1, 2, 9 Filipek A....Kuznicki J. (2002)
    2. Solution NMR structure and dynamics of human apo-S100A1 protein. (PubMed id 21296671)1, 2 Nowakowski M.... Ejchart A. (2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Heterodimeric interaction and interfaces of S100A1 an d S100P. (PubMed id 15171681)1, 2 Wang G....Barraclough R. (2004)
    6. S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. (PubMed id 1384693)1, 2 Engelkamp D.... Heizmann C.W. (1992)
    7. Structure and chromosome assignment of human S100 alpha and beta subunit genes. (PubMed id 1998503)1, 3 Morii K....Kuwano R. (1991)
    8. Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. (PubMed id 11944917)7, 9 Okada M....Kobayashi R. (2002)
    9. Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. (PubMed id 17483815)1, 9 Rocca P.C....Martignoni G. (2007)
    10. The role of S100A1 in external auditory canal cholesteatoma. (PubMed id 16969478)1, 9 Naim R. and Hormann K. (2006)

    External Searches for S100A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing S100A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6271 HGNC: 10486 AceView: S100A1 Ensembl:ENSG00000160678 euGenes: HUgn6271
    ECgene: S100A1 H-InvDB: S100A1

    Other Databases showing S100A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing S100A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for S100A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for S100A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for S100A1 gene:
    Search GeneIP for patents involving S100A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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