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S100A1 Gene

protein-coding   GIFtS: 56

GC01P151867
S100 calcium binding protein A1
(Previous name: S100 calcium-binding protein A1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: S100A)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000035100 2
S100 2
S100-alpha 1, 2
S100A 2, 3
Descriptions
S-100 protein alpha chain 3
S-100 protein subunit alpha 3
S100 alpha 2
S100 calcium binding protein A1 2
S100 calcium-binding protein A1 1, 2, 3
S100 protein, alpha polypeptide 2
External Ids
HGNC: 104861
Entrez Gene: 62712
UniProtKB: P232973
Ensembl: ENSG000001606787
Search outside databases for aliases for S100A1 gene

Previous GC identifers: GC01P151365 GC01P149331 GC01P150376 GC01P150817 GC01P150414

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S100A1:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand
calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide
range of cells, and involved in the regulation of a number of cellular processes such as cell
cycle progression and differentiation. S100 genes include at least 13 members which are located as
a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+
release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated
phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
[provided by RefSeq]

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different
affinities exist for both ions on each monomer. Physiological concentrations of potassium ion
antagonize the binding of both divalent cations, especially affecting high-affinity
calcium-binding sites

Gene Wiki entry for S100A1 (S100_calcium_binding_protein_A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the S100A1 gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

S100A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151867:     (about GC identifiers)

Start:
151,867,173 bp from pter
End:
151,871,137 bp from pter
Size:
3,965 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297 (See protein sequence)
Recommended Name: Protein S100-A1  
Size: 94 amino acids; 10546 Da
Subunit: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain
Subcellular location: Cytoplasm
Secondary accessions: Q5T7Y3

REFSEQ proteins: NP_006262.1  

ENSEMBL proteins: 
ENSP00000357687 ENSP00000292169 ENSP00000357685 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (S100 alpha, S100)
Human Recombinant Proteins from Abnova (S100A1)
              OriGene Purified Recombinant Human Protein: S100A1 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
GO:0016529 sarcoplasmic reticulum IDA12804600
GO:0043231 intracellular membrane-bounded organelle IDA18029348
GO:0043234 protein complex NAS14638689
About this table

Antibodies for S100A1: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of S100A1
Sigma-Aldrich Antibody Arrays and Antibodies for S100A1
R&D Systems Antibodies for S100A1
Antibodies from Abcam (S100 alpha, S100), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (S100A1)
Novus Biologicals Antibodies for S100A1

Assays for S100A1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/6 InterPro domains/families (see all 6 ):
 IPR018247 EF_HAND_1
 IPR011992 EF-Hand_type
 IPR018248 EF_hand
 IPR013787 S100_Ca_bd_sub
 IPR018249 EF_HAND_2


   GeneDecks  S100A1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P23297

ProtoNet protein and cluster: P23297

1 Blocks protein family: IPB001751 Calcium-binding protein

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
Similarity: Belongs to the S-100 family
Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (S100A1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (S100A1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006271

              Applied Biosystems Silencer® siRNAs for S100A1

              Sigma-Aldrich siRNA for S100A1  
                     Sigma-Aldrich shRNA for S100A1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for S100A1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006271
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006271
                                 untagged cDNA clone in CMV expression vector: NM_006271 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006271

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different
affinities exist for both ions on each monomer. Physiological concentrations of potassium ion
antagonize the binding of both divalent cations, especially affecting high-affinity
calcium-binding sites

Genatlas biochemistry entry for S100A1:
S100 calcium binding protein A1,epidermal diffentiation complex

4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for S100a1):

behavior/neurologicalmusclenormal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005509 calcium ion binding TAS1998503
GO:0008270 zinc ion binding IEA--
GO:0042803 protein homodimerization activity IDA10913138
GO:0048154 S100 beta binding IPI10913138
GO:0048155 S100 alpha binding IPI10913138
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  S100A1 


5/17 Interacting proteins for S100A1 (P232971 ENSP000003576873) via UniProtKB, MINT, and/or STRING (see all 17 )
InteractantInteraction Details
GeneCardExternal ID(s)
S100BP042711, ENSP000002917003EBI-743686, EBI-458391 STRING (score=.953)
S100A1P232971EBI-743686, EBI-743686
S100PP258151EBI-743686, EBI-743700
ANXA6ENSP000003465503STRING (score=.971)
S100A4ENSP000003462943STRING (score=.954)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007242 intracellular signaling cascade NAS12804600
GO:0008016 regulation of heart contraction NAS12804600
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for S100A1
10/16 Novoseek chemical compound relationships for S100A1 gene (see all 16 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
mucicarmine 46.80 1 8776426 (1)
glycogen 39.32 2 8370068 (2)
hematoxylin 38.33 2 15807305 (1), 2012790 (1)
progesterone 36.96 16 12883239 (1), 15807314 (1), 16160476 (1), 9648158 (1) (see all 15)
b 723 35.51 2 12647218 (1), 9777982 (1)
ferric oxide 33.64 2 10491956 (1), 14703110 (1)
calcium 30.82 92 18384084 (6), 9562557 (5), 8894274 (4), 15885104 (4) (see all 36)
actomyosin 22.43 2 7798169 (1), 12482578 (1)
toluidine 20.05 1 2012790 (1)
nacl 5.02 1 15885104 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (S100A1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (S100A1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006271

              Sigma-Aldrich siRNA for S100A1  
                     Sigma-Aldrich shRNA for S100A1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006271  

REFSEQ mRNAs for S100A1 gene: 

NM_006271.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006271  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006271
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006271
                                 untagged cDNA clone in CMV expression vector: NM_006271 

Additional cDNA sequence: 

AB451316.1 AB451446.1 AK312152.1 BC014392.1 BC072006.1 BC094843.1 BT006938.1 X58079.1 

14 DOTS entries:

DT.97861882  DT.86821086  DT.95154778  DT.100032143  DT.121412413  DT.102840744  DT.92429590  DT.92429603 
DT.121412367  DT.92429605  DT.95318019  DT.91940742  DT.97791395  DT.97864090 

24/185 AceView cDNA sequences (see all 185 ):

BM694560 F35232 BM723401 BE900737 AI625362 BM711668 BM716207 AI300836 
AA330750 BM704736 BM694862 H22491 X58079 NM_006271 BM719637 AL120020 
BM717929 BG576755 BM727863 BQ186679 BE902396 AI352680 H41365 BM702456 

highest scoring ESTs for S100A1:

X58079 AA176459 AA176728 AA192613 AA192844 AA192865 AA195927 AA293330 AA330750 AA425934 

Unigene Cluster for S100A1:

S100 calcium binding protein A1
Hs.515715  [show with all ESTs]
Unigene Representative Sequence: BM472825


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000368698  ENST00000292169  ENST00000368696  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S100A1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for S100A1

1 / 2 / 3

3 probe-sets matching S100A1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
34674_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 X58079 1.00 1.00 1.00 1

205334_at2, 3 U133-A 2 1.00 0.86 -- -- NM_006271 0.60 1.00 0.82 1

205334_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --
GeneDecks  S100A1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.515715

Expression variation in blood from EXPOLDB for S100A1

UniProtKB/Swiss-Prot: S10A1_HUMAN, P23297
Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle
and brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for S100A1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
S100A11   -- S100 calcium binding protein A1 92.91(n)
97.87(a)
480141  XM_537265.2  XP_537265.1 
chimpanzee
(Pan troglodytes)
S100A11   -- S100 calcium binding protein A1 100(n)
100(a)
457325  XM_513820.2  XP_513820.2 
cow
(Bos taurus)
S100A11   -- S100 calcium binding protein A1 93.62(n)
98.94(a)
786100  XM_001253724.1  XP_001253725.1 
rat
(Rattus norvegicus)
S100a11   -- S100 calcium binding protein A1 89.36(n)
93.62(a)
295214  NM_001007636.1  NP_001007637.1 
mouse
(Mus musculus)
S100a11, 5 3 (43.60 cM)5
S100 calcium binding protein A11, 5 87.59(n)1
93.62(a)1
201931  NM_011309.31  NP_035439.11 
 AA1099395  AF0876875  (see all 14)
About this table        Species with no ortholog for S100A1

ENSEMBL Gene Tree for S100A1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for S100A1 gene
S100A62  S100A32  S100Z2  S100A52  S100A22  S100A42  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --
(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176940

10/92 Novoseek disease relationships for S100A1 gene (see all 92 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
myoepithelioma 81.69 3 15619979 (1), 15717758 (1), 16099771 (1)
gastrointestinal stromal tumor 81.03 2 19108033 (1), 16892012 (1)
stromal tumors 78.96 2 2192100 (1), 15223969 (1)
smooth muscle tumor 76.81 3 16400320 (1), 18505417 (1), 15796874 (1)
tumors 72.01 227 16422363 (3), 1612579 (3), 7693778 (3), 1803052 (2) (see all 99)
leiomyosarcoma 71.83 4 18505417 (1), 14633453 (1), 15796874 (1), 18250540 (1)
neurothekeoma 70.12 2 10891717 (1)
peripheral nerve sheath tumors 67.39 1 16316954 (1)
malignant peripheral nerve sheath tumors 66.27 1 19154261 (1)
mpnst 65.40 6 18547346 (3), 1803052 (1), 11536443 (1), 16481232 (1)
About this table

Human Genome Epidemiology Navigator: S100A1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/594 PubMed articles for S100A1 gene (see all 594 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6271 HGNC: 10486 AceView: S100A1 Ensembl:ENSG00000160678 euGenes: HUgn6271
ECgene: S100A1 H-InvDB: S100A1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for S100A1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for S100A1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for S100A1 Antibodies for S100A1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for S100A1 Browse small molecules at Sigma-Aldrich
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 Recombinant Proteins
(S100 alpha, S100)
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 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for S100A1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for S100A1

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