Aliases for RYR3 Gene
Aliases for RYR3 Gene
External Ids for RYR3 Gene
- HGNC: 10485
- Entrez Gene: 6263
- Ensembl: ENSG00000198838
- OMIM: 180903
- UniProtKB: Q15413
Previous GeneCards Identifiers for RYR3 Gene
- GC15P028845
- GC15P026310
- GC15P031182
- GC15P031319
- GC15P031390
- GC15P033603
- GC15P010464
Summaries for RYR3 Gene
-
The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for RYR3 Gene
RYR3 (Ryanodine Receptor 3) is a Protein Coding gene. Diseases associated with RYR3 include Central Core Disease and Alzheimer Disease. Among its related pathways are Activation of cAMP-Dependent PKA and Ion channel transport. GO annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is RYR2.
UniProtKB/Swiss-Prot for RYR3 Gene
-
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RYR3 Gene
Genomics for RYR3 Gene
Regulatory Elements for RYR3 Gene
Enhancers for RYR3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH15F033357 | 0.8 | FANTOM5 ENCODE | 16.3 | +47.6 | 47629 | 1.1 | CEBPA HLF FOS CEBPG | RYR3 LOC101928134 GC15P033628 |
| GH15F033278 | 1 | Ensembl ENCODE | 11.5 | -31.5 | -31457 | 1.7 | CTCF JUN ZIC2 HIC1 JUND GLIS2 ZNF692 PATZ1 GLIS1 FOSL2 | RYR3 ENSG00000212415 TMCO5B LOC101928134 |
| GH15F033720 | 1.1 | FANTOM5 Ensembl ENCODE | 10.2 | +411.0 | 411037 | 2.6 | JUND JUN MYC SPI1 | RYR3 LOC101928134 AVEN GC15P033723 C1QBPP3 |
| GH15F033241 | 1 | Ensembl ENCODE | 11.2 | -67.3 | -67281 | 4.6 | CTCF JUN INSM2 RAD21 FOS MAFK TCF7L2 ZNF639 RFX1 ZNF654 | TMCO5B RYR3 LOC105370759 |
| GH15F033311 | 0.6 | FANTOM5 | 15.2 | +1.0 | 1006 | 0.2 | CTCF CBX8 HLF MAFK RAD21 | RYR3 FMN1 GC15P033628 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RYR3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RYR3 gene promoter:
Regulatory Element Products
Genomic Location for RYR3 Gene
- Chromosome:
- 15
- Start:
- 33,310,783 bp from pter
- End:
- 33,866,121 bp from pter
- Size:
- 555,339 bases
- Orientation:
- Plus strand
Genomic View for RYR3 Gene
Genes around RYR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q13.3 by Ensembl
- 15q13.3-q14 by Entrez Gene
- 15q13.3-q14 by HGNC
RYR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RYR3 Gene
Proteins for RYR3 Gene
-
Protein details for RYR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15413-RYR3_HUMAN
- Recommended name:
- Ryanodine receptor 3
- Protein Accession:
- Q15413
- O15175
- Q15412
Protein attributes for RYR3 Gene
- Size:
- 4870 amino acids
- Molecular mass:
- 552042 Da
- Quaternary structure:
-
- Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SEPN1 (By similarity).
- Miscellaneous:
-
- Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg(2+) and ruthenium red (By similarity).
- SequenceCaution:
-
- Sequence=BAA23795.1; Type=Frameshift; Positions=742, 766; Evidence={ECO:0000305};
Protein Expression for RYR3 Gene
Post-translational modifications for RYR3 Gene
Other Protein References for RYR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for RYR3
-
Custom Antibody ServicesOriGene Antibodies for RYR3
- antibodies-online Antibodies for RYR3: See all 10
- Search GeneTex for Antibodies for RYR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for RYR3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RYR3
- Origene Custom Protein Services for RYR3
- Search GeneTex for Proteins for RYR3
Assay Products
No data available for DME Specific Peptides for RYR3 Gene
Domains & Families for RYR3 Gene
Gene Families for RYR3 Gene
- HGNC:
- IUPHAR :
Protein Domains for RYR3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RYR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15413UniProtKB/Swiss-Prot:
RYR3_HUMAN :- The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
- Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily.
- Domain:
-
- The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
- Contains 3 B30.2/SPRY domains.
- Contains 5 MIR domains.
- Family:
-
- Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily.
Function for RYR3 Gene
Molecular function for RYR3 Gene
- GENATLAS Biochemistry:
- ryanodine receptor 3 (calcium release channel),expressed in cardiac and neonatal skeletal muscle in aorta,esophagus,lung,with alternative spliced isoforms,and coexpressed with ITPR3 in neurons and in hippocampal CA1 pyramidal cell layer,in the caudale/putamen,olfactory bulb and olfactory tubercle,smooth muscle cells,involved in special form of hippocampal synaptic plasticity (for adaptation of acquired memory flexibility to environmental changes)
- UniProtKB/Swiss-Prot Function:
- Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005219 | ryanodine-sensitive calcium-release channel activity | IEA,TAS | 19095005 |
| GO:0005262 | calcium channel activity | IEA | -- |
| GO:0005509 | calcium ion binding | IEA,IBA | -- |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0015278 | calcium-release channel activity | IMP | 9395096 |
Phenotypes for RYR3 Gene
- MGI mutant phenotypes for RYR3:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for RYR3:
-
- Mitotic spindle defects
- Increased vaccinia virus (VACV) infection
- Decreased ionizing radiation sensitivity
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased IL-8 secretion
- Downregulation of Wnt pathway after Wnt3A stimulation
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Models for RYR3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for RYR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RYR3 gene
- Search ViGene Biosciences for RYR3
CRISPR Products
-
OriGene CRISPR knockouts for RYR3
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miRNA for RYR3 Gene
- miRTarBase miRNAs that target RYR3
miRNA Products
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Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for RYR3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RYR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RYR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RYR3
-
ViGene Biosciences adenoviral particle packaged cDNA for RYR3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RYR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RYR3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RYR3 Gene
Localization for RYR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RYR3 Gene
- Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Sarcoplasmic reticulum. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 4 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005790 | smooth endoplasmic reticulum | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,ISS | -- |
Pathways & Interactions for RYR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Cardiac conduction |
.39
|
|
| 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 4 | Ion channel transport | ||
| 5 | Myometrial Relaxation and Contraction Pathways | ||
Pathways by source for RYR3 Gene
3 BioSystems pathways for RYR3 Gene
6 Reactome pathways for RYR3 Gene
5 KEGG pathways for RYR3 Gene
9 Qiagen pathways for RYR3 Gene
Interacting Proteins for RYR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006816 | calcium ion transport | IEA,IMP | 9395096 |
| GO:0006874 | cellular calcium ion homeostasis | IEA | -- |
| GO:0034220 | ion transmembrane transport | IEA,TAS | -- |
No data available for SIGNOR curated interactions for RYR3 Gene
Drugs & Compounds for RYR3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Caffeine | Approved | Nutra | Antagonist, antagonist | A1 and A2B antagonist. CNS stimulant | 380 | |
| Dantrolene | Approved | Pharma | Antagonist, antagonist | 5 | ||
| Ryanodine | Pharma | Channel blocker | 0 | |||
| ATP | Pharma | Agonist | 0 | |||
| Ca<sup>2+</sup> | Pharma | Activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| JTV 519 fumarate |
|
|
|
(2) Tocris Compounds for RYR3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Caffeine | A1 and A2B antagonist. CNS stimulant | 58-08-2 |
| JTV 519 fumarate | Ryanodine receptor (RyR) inhibitor |
(1) ApexBio Compounds for RYR3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chlorocresol | 59-50-7 |
Drug Products
- ApexBio compounds for RYR3
Transcripts for RYR3 Gene
mRNA/cDNA for RYR3 Gene
- (13) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (35) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RYR3
- GenScript: Design CRISPR guide RNA sequences for RYR3
miRNA Products
- Search ViGene Biosciences for RYR3
Inhibitory RNA Products
- Origene RNAi, mouse_rna, siRNA, and shRNA products in human, mouse, rat for RYR3
- Browse OriGene Inhibitory RNA Products For RYR3
-
ViGene Biosciences ready-to-package AAV shRNAs for RYR3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RYR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RYR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for RYR3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Megakaryocyte-Erythroid Precursor Cells Hematopoietic Bone Marrow
- Conventional Dendritic Cells II Spleen
- Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for RYR3 Gene
This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.1), Muscle - Skeletal (x5.0), and Brain - Caudate (basal ganglia) (x4.3).
This gene is overexpressed in Heart (30.9), NK cells (13.2), Liver (12.5), and Lung (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RYR3 Gene
NURSA nuclear receptor signaling pathways regulating expression of RYR3 Gene:
RYR3SOURCE GeneReport for Unigene cluster for RYR3 Gene:
Hs.709373mRNA Expression by UniProt/SwissProt for RYR3 Gene:
Q15413-RYR3_HUMAN
Tissue specificity:
Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.
Primer Products
-
OriGene qPCR primer pairs for RYR3
No data available for Protein tissue co-expression partners for RYR3 Gene
Orthologs for RYR3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RYR3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RYR3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RYR3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RYR3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ryr3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ryr3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | RYR3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RYR3 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1516 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | RYR3 (1 of 3) 35 |
|
OneToMany | |
| RYR3 (3 of 3) 35 |
|
OneToMany | |||
| ryr3 34 35 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Rya-r44F 36 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | unc-68 36 |
|
|
- Species where no ortholog for RYR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for RYR3 Gene
Variants for RYR3 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs762176717 | Uncertain significance | 33,662,521(+) | GCCCG(C/G)GTTCA | nc-transcript-variant, reference, missense | |
| rs869312926 | Uncertain significance | 33,756,359(+) | AGATC(A/G)AATTC | nc-transcript-variant, reference, missense | |
| rs431825174 | untested | 33,857,900(+) | AGTGC(A/G)ACGAC | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs431825175 | untested | 33,660,330(+) | GAAGG(C/T)GGAGA | nc-transcript-variant, reference, missense | |
| rs10152201 | -- | 33,600,615(+) | TCTTA(C/G)ATTCA | intron-variant |
Residual Variation Intolerance Score:
0.379% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.68;
95.72% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RYR3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RYR3 Gene
Disorders for RYR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| central core disease |
|
|
| alzheimer disease |
|
|
Search RYR3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for RYR3
No data available for UniProtKB/Swiss-Prot and Genatlas for RYR3 Gene
Publications for RYR3 Gene
- Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization. (PMID: 8276408) Sorrentino V. … Mattei M.-G. (Genomics 1993) 2 3 4 22 64
- A genome-wide association study of carotid atherosclerosis in HIV-infected men. (PMID: 20009918) Shrestha S. … Grunfeld C. (AIDS 2010) 3 22 46 64
- No association between the ryanodine receptor 3 gene and autism in a Japanese population. (PMID: 18588595) Tochigi M. … Sasaki T. (Psychiatry Clin. Neurosci. 2008) 3 22 46 64
- Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex. (PMID: 12354756) Schwarzmann N. … Guse A.H. (J. Biol. Chem. 2002) 3 4 22 64
- cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene. (PMID: 9515741) Leeb T. … Brenig B. (FEBS Lett. 1998) 3 4 22 64
Products for RYR3 Gene
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- Novus Biologicals
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- ViGene Biosciences adenoviral particle packaged cDNA for RYR3 gene
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- Horizon Cell Lines for RYR3
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- VectorBuilder custom plasmid, inducible vectors for RYR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RYR3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RYR3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
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