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Aliases for RYR2 Gene

Aliases for RYR2 Gene

  • Ryanodine Receptor 2 (Cardiac) 2 3
  • Cardiac Muscle Ryanodine Receptor-Calcium Release Channel 3 4
  • Type 2 Ryanodine Receptor 3 4
  • ARVD2 3 6
  • ARVC2 3 6
  • VTSIP 3 6
  • RYR-2 3 4
  • Arrhythmogenic Right Ventricular Dysplasia 2 2
  • Cardiac Muscle Ryanodine Receptor 4
  • Cardiac-Type Ryanodine Receptor 3
  • Kidney-Type Ryanodine Receptor 3
  • Islet-Type Ryanodine Receptor 3
  • Ryanodine Receptor 2 3
  • HRYR-2 4
  • RyR2 4
  • RYR 3

External Ids for RYR2 Gene

Previous HGNC Symbols for RYR2 Gene

  • ARVD2

Previous GeneCards Identifiers for RYR2 Gene

  • GC01P235338
  • GC01P232659
  • GC01P233502
  • GC01P234246
  • GC01P233531
  • GC01P237205
  • GC01P207662

Summaries for RYR2 Gene

Entrez Gene Summary for RYR2 Gene

  • This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for RYR2 Gene

RYR2 (Ryanodine Receptor 2 (Cardiac)) is a Protein Coding gene. Diseases associated with RYR2 include ventricular tachycardia, catecholaminergic polymorphic, 1 and arrhythmogenic right ventricular dysplasia 2. Among its related pathways are CREB Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is RYR1.

UniProtKB/Swiss-Prot for RYR2 Gene

  • Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Gene Wiki entry for RYR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RYR2 Gene

Genomics for RYR2 Gene

Regulatory Elements for RYR2 Gene

Genomic Location for RYR2 Gene

Start:
237,042,205 bp from pter
End:
237,833,988 bp from pter
Size:
791,784 bases
Orientation:
Plus strand

Genomic View for RYR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RYR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RYR2 Gene

Proteins for RYR2 Gene

  • Protein details for RYR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92736-RYR2_HUMAN
    Recommended name:
    Ryanodine receptor 2
    Protein Accession:
    Q92736
    Secondary Accessions:
    • Q15411
    • Q546N8
    • Q5T3P2

    Protein attributes for RYR2 Gene

    Size:
    4967 amino acids
    Molecular mass:
    564567 Da
    Quaternary structure:
    • Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A.
    Miscellaneous:
    • Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity).
    SequenceCaution:
    • Sequence=CAH71369.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305}; Sequence=CAH71393.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305}; Sequence=CAH73918.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305}; Sequence=CAI14440.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305}; Sequence=CAI15350.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305}; Sequence=CAI15936.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305}; Sequence=CAI22065.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RYR2 Gene

    Alternative splice isoforms for RYR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RYR2 Gene

Proteomics data for RYR2 Gene at MOPED

Post-translational modifications for RYR2 Gene

  • Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels.
  • Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RYR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RYR2 Gene

Domains for RYR2 Gene

Gene Families for RYR2 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • RYR :Ion channels / Ryanodine receptors
IUPHAR :

Suggested Antigen Peptide Sequences for RYR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92736

UniProtKB/Swiss-Prot:

RYR2_HUMAN :
  • Q92736
Domain:
  • The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
  • Contains 3 B30.2/SPRY domains.
  • Contains 5 MIR domains.
Family:
  • Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.
genes like me logo Genes that share domains with RYR2: view

Function for RYR2 Gene

Molecular function for RYR2 Gene

GENATLAS Biochemistry: ryanodine receptor 2,controlling intracellular Ca2+ levels by releasing Ca2+ from the sarcoplasmic reticulum,expressed in skeletal and cardiac muscle
UniProtKB/Swiss-Prot Function: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
UniProtKB/Swiss-Prot Induction: By TGFB1.

Gene Ontology (GO) - Molecular Function for RYR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005218 intracellular ligand-gated calcium channel activity ISS --
GO:0005219 ryanodine-sensitive calcium-release channel activity IDA 17921453
GO:0005262 calcium channel activity ISS --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with RYR2: view
genes like me logo Genes that share phenotypes with RYR2: view

Animal Models for RYR2 Gene

MGI Knock Outs for RYR2:

Animal Model Products

CRISPR Products

miRNA for RYR2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RYR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RYR2 Gene

Localization for RYR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RYR2 Gene

Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RYR2 Gene COMPARTMENTS Subcellular localization image for RYR2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RYR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005886 plasma membrane ISS --
GO:0014701 junctional sarcoplasmic reticulum membrane TAS 17569730
GO:0016020 membrane IDA 12443530
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with RYR2: view

Pathways for RYR2 Gene

genes like me logo Genes that share pathways with RYR2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RYR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia ISS --
GO:0002027 regulation of heart rate IMP 11159936
GO:0003143 embryonic heart tube morphogenesis ISS --
GO:0003220 left ventricular cardiac muscle tissue morphogenesis ISS --
GO:0003300 cardiac muscle hypertrophy ISS --
genes like me logo Genes that share ontologies with RYR2: view

Compounds for RYR2 Gene

(2) HMDB Compounds for RYR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4

(8) IUPHAR Ligand for RYR2 Gene

Ligand Type Action Affinity Pubmed IDs
ATP Activator None
ryanodine Activator None
suramin Activator None
procaine Channel blocker None
caffeine Activator None
Ca2+ Antagonist Antagonist
ruthenium red Channel blocker None
Mg2+ Antagonist Antagonist

(27) Novoseek inferred chemical compound relationships for RYR2 Gene

Compound -log(P) Hits PubMed IDs
ryanodine 96.5 114
4-chloro-m-cresol 75.5 4
calcium 72.9 147
caffeine 72.7 19
inositol 1,4,5 trisphosphate 56.3 2

(1) PharmGKB related drug/compound annotations for RYR2 Gene

Drug/compound Annotation
cerivastatin CA
genes like me logo Genes that share compounds with RYR2: view

Transcripts for RYR2 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RYR2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RYR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RYR2 Gene

No ASD Table

Relevant External Links for RYR2 Gene

GeneLoc Exon Structure for
RYR2
ECgene alternative splicing isoforms for
RYR2

Expression for RYR2 Gene

mRNA expression in normal human tissues for RYR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RYR2 Gene

This gene is overexpressed in Heart - Left Ventricle (22.0) and Heart - Atrial Appendage (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RYR2 Gene

SOURCE GeneReport for Unigene cluster for RYR2 Gene Hs.109514

mRNA Expression by UniProt/SwissProt for RYR2 Gene

Q92736-RYR2_HUMAN
Tissue specificity: Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
genes like me logo Genes that share expressions with RYR2: view

In Situ Assay Products

Orthologs for RYR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RYR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RYR2 35
  • 99.47 (n)
  • 99.92 (a)
RYR2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC537376 35
  • 91.42 (n)
  • 98.11 (a)
RYR2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RYR2 35
  • 91.55 (n)
  • 98.3 (a)
RYR2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ryr2 35
  • 87.03 (n)
  • 97.36 (a)
Ryr2 16
Ryr2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RYR2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RYR2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ryr2 35
  • 86.84 (n)
  • 97.21 (a)
chicken
(Gallus gallus)
Aves RYR2 35
  • 82.35 (n)
  • 93.75 (a)
RYR2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ryr1 35
  • 67.12 (n)
  • 69.29 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01065506.1 36
  • 99 (a)
OneToMany
ryr1b 35
  • 66.42 (n)
  • 68.88 (a)
ryr2a 36
  • 98 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010750 35
  • 54.76 (n)
  • 51.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rya-r44F 35
  • 54.32 (n)
  • 49.21 (a)
Rya-r44F 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-68 35
  • 52.99 (n)
  • 47.1 (a)
unc-68 37
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5494 35
Species with no ortholog for RYR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RYR2 Gene

ENSEMBL:
Gene Tree for RYR2 (if available)
TreeFam:
Gene Tree for RYR2 (if available)

Paralogs for RYR2 Gene

Paralogs for RYR2 Gene

Selected SIMAP similar genes for RYR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RYR2: view

Variants for RYR2 Gene

Sequence variations from dbSNP and Humsavar for RYR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3862 -- 237,409,966(-) GTAGA(A/G)TATAT intron-variant
rs12594 -- 237,833,787(+) GTTGC(A/G)TCACA utr-variant-3-prime
rs169165 -- 237,199,409(-) GCTTT(G/T)GGACT intron-variant
rs169166 -- 237,199,450(-) GGATG(C/T)TTCCT intron-variant
rs174867 -- 237,193,165(+) aaagt(A/C)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RYR2 Gene

Variant ID Type Subtype PubMed ID
nsv873334 CNV Loss 21882294
esv2670053 CNV Deletion 23128226
nsv468506 CNV Loss 19166990
nsv832982 CNV Gain 17160897
nsv520100 CNV Loss 19592680
nsv521224 CNV Loss 19592680
esv2669499 CNV Deletion 23128226
nsv516399 CNV Loss 19592680
nsv5032 CNV Insertion 18451855
esv2666294 CNV Deletion 23128226
nsv873335 CNV Loss 21882294
nsv160668 CNV Insertion 16902084
esv1753526 CNV Insertion 17803354
esv2725585 CNV Deletion 23290073
esv271004 CNV Insertion 20981092
esv274049 CNV Insertion 20981092
nsv873336 CNV Loss 21882294
nsv873337 CNV Loss 21882294
nsv523073 CNV Loss 19592680
esv2725596 CNV Deletion 23290073
nsv524393 CNV Loss 19592680
esv2725607 CNV Deletion 23290073
nsv873338 CNV Loss 21882294
nsv873339 CNV Gain 21882294
esv1451750 CNV Insertion 17803354
nsv873340 CNV Loss 21882294
esv2725618 CNV Deletion 23290073
esv2725629 CNV Deletion 23290073
esv2725640 CNV Deletion 23290073
esv2136360 CNV Deletion 18987734
esv2725651 CNV Deletion 23290073
nsv159991 CNV Loss 16902084
esv2725662 CNV Deletion 23290073
nsv160537 CNV Loss 16902084
esv24945 CNV Loss 19812545
esv2725673 CNV Deletion 23290073
esv2725684 CNV Deletion 23290073
esv2725696 CNV Deletion 23290073
esv2725707 CNV Deletion 23290073
esv2725718 CNV Deletion 23290073
esv2666770 CNV Deletion 23128226
nsv827498 CNV Gain 20364138
nsv873341 CNV Loss 21882294
esv8781 CNV Gain 19470904
dgv193e1 CNV Complex 17122850
nsv820221 CNV Gain 19587683
esv1756390 CNV Insertion 17803354
nsv8946 CNV Gain 18304495
esv271972 CNV Insertion 20981092
esv272255 CNV Insertion 20981092
nsv827509 CNV Loss 20364138

Relevant External Links for RYR2 Gene

HapMap Linkage Disequilibrium report
RYR2
Human Gene Mutation Database (HGMD)
RYR2
Locus Specific Mutation Databases (LSDB)
RYR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RYR2 Gene

Disorders for RYR2 Gene

(2) OMIM Diseases for RYR2 Gene (180902)

UniProtKB/Swiss-Prot

RYR2_HUMAN
  • Arrhythmogenic right ventricular dysplasia, familial, 2 (ARVD2) [MIM:600996]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. {ECO:0000269 PubMed:11159936}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy (CPVT1) [MIM:604772]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269 PubMed:11157710, ECO:0000269 PubMed:12093772, ECO:0000269 PubMed:12106942, ECO:0000269 PubMed:15046072, ECO:0000269 PubMed:15046073, ECO:0000269 PubMed:15466642, ECO:0000269 PubMed:15544015}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for RYR2 Gene

(25) Novoseek inferred disease relationships for RYR2 Gene

Disease -log(P) Hits PubMed IDs
ventricular tachycardia, catecholaminergic polymorphic 97.5 35
ventricular tachycardia, familial polymorphic 89.2 4
arrhythmogenic right ventricular dysplasia 77.9 10
death sudden cardiac 77.2 22
central core disease 76.7 5

Relevant External Links for RYR2

GeneTests
RYR2
GeneReviews
RYR2
Genetic Association Database (GAD)
RYR2
Human Genome Epidemiology (HuGE) Navigator
RYR2
genes like me logo Genes that share disorders with RYR2: view

Publications for RYR2 Gene

  1. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). (PMID: 11159936) Tiso N. … Rampazzo A. (Hum. Mol. Genet. 2001) 2 3 4 23
  2. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. (PMID: 11208676) Priori S.G. … Danieli G.A. (Circulation 2001) 3 4 23
  3. Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes. (PMID: 8406504) Otsu K. … MacLennan D.H. (Genomics 1993) 2 3 23
  4. Differential expression of ryanodine receptor RyR2 mRNA in the non- pregnant and pregnant human myometrium. (PMID: 9148749) Awad S.S. … Gillespie J.I. (Biochem. J. 1997) 3 4 23
  5. Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. (PMID: 9607712) Martin C. … Ashley R.H. (Neuroscience 1998) 3 4 23

Products for RYR2 Gene

Sources for RYR2 Gene

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