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RYR1 Gene

protein-coding   GIFtS: 70
GCID: GC19P038924

Ryanodine Receptor 1 (Skeletal)

(Previous name: central core disease of muscle)
(Previous symbols: MHS, MHS1, CCO)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ryanodine Receptor 1 (Skeletal)1 2     RYR2
CCO1 2 5     SKRR2
MHS1 2 5     Ryanodine Receptor 12
MHS11 2     Sarcoplasmic Reticulum Calcium Release Channel2
Central Core Disease Of Muscle1 2     Type 1-Like Ryanodine Receptor2
Skeletal Muscle Calcium Release Channel2 3     RyR13
Skeletal Muscle Ryanodine Receptor2 3     Skeletal Muscle-Type Ryanodine Receptor3
RYDR2 3     Type 1 Ryanodine Receptor3
RYR-12 3     

External Ids:    HGNC: 104831   Entrez Gene: 62612   Ensembl: ENSG000001962187   OMIM: 1809015   UniProtKB: P218173   

Export aliases for RYR1 gene to outside databases

Previous GC identifers: GC19P039538 GC19P039315 GC19P043600 GC19P043616 GC19P035371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RYR1 Gene:
This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium
release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and
transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core
disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding
different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for RYR1 Gene:
RYR1 (ryanodine receptor 1 (skeletal)) is a protein-coding gene. Diseases associated with RYR1 include malignant hyperthermia, and king denborough syndrome. GO annotations related to this gene include protease binding and calcium ion binding. An important paralog of this gene is RYR2.

UniProtKB/Swiss-Prot: RYR1_HUMAN, P21817
Function: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm
and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated
very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the
cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote
prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal
muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By
similarity)

Gene Wiki entry for RYR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RYR1 gene promoter:
         AhR   CREB   p53   NRSF form 1   deltaCREB   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRYR1 promoter sequence
   Search Chromatin IP Primers for RYR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RYR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

RYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RYR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P038924:  view genomic region     (about GC identifiers)

Start:
38,924,339 bp from pter      End:
39,078,204 bp from pter
Size:
153,866 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RYR1_HUMAN, P21817 (See protein sequence)
Recommended Name: Ryanodine receptor 1  
Size: 5038 amino acids; 565176 Da
Subunit: Homotetramer. Can also form heterotetramers with RYR2. Interacts with CALM; CALM with bound calcium
inhibits the RYR1 channel activity. Interacts with S100A1. Interacts with FKBP1A; this stabilizes the closed
conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the
RYR1 channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel
activity (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1
(PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1)
Miscellaneous: Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel
with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High
ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The
calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP.
Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By
similarity)
Miscellaneous: Coexpression of normal and mutant Thr-4898 RYR1 in a 1:1 ratio, produces RYR1 channels with normal
halothane and caffeine sensitivities, but maximal levels of Ca(2+) release are reduced by 67%. Binding of
[3H]ryanodine indicates that the heterozygous channel is activated by Ca(2+) concentrations 4-fold lower than
normal. Single-cell analysis of cotransfected cells shows a significantly increased resting cytoplasmic Ca(2+)
level and a significantly reduced luminal Ca(2+) level. These data indicated a leaky channel, possibly caused by
a reduction in the Ca(2+) concentration required for channel activation. Comparison with 2 other coexpressed
mutant/normal channels suggests that the Thr-4898 mutation produces one of the most abnormal RYR1 channels that
has been investigated, and this level of abnormality is reflected in the severe and penetrant phenotype of
affected CCD individuals
Secondary accessions: Q16314 Q16368 Q9NPK1 Q9P1U4
Alternative splicing: 3 isoforms:  P21817-1   P21817-2   P21817-3   

Explore the universe of human proteins at neXtProt for RYR1: NX_P21817

Explore proteomics data for RYR1 at MOPED

Post-translational modifications: 

  • Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity.
    Repeated very high-level exercise increases phosphorylation at Ser-28431
  • Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation1
  • Ubiquitination2 at Lys2069
  • Modification sites at PhosphoSitePlus

  • See RYR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000531.2  NP_001036188.1  

    ENSEMBL proteins: 
     ENSP00000347667   ENSP00000352608   ENSP00000470927   ENSP00000471601   ENSP00000472497  
     ENSP00000470848   ENSP00000471404   ENSP00000472126   ENSP00000354254  
    Reactome Protein details: P21817

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RYR: Ion channels / Ryanodine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RyR1
    Ryanodine receptor

    Selected InterPro protein domains (see all 14):
     IPR014821 Ins145_P3_rcpt
     IPR003032 Ryanodine_rcpt
     IPR001870 B30.2/SPRY
     IPR011992 EF-hand-dom_pair
     IPR013662 RIH_assoc-dom

    Graphical View of Domain Structure for InterPro Entry P21817

    ProtoNet protein and cluster: P21817

    5 Blocks protein domains:
    IPB000699 Intracellular calcium-release channel
    IPB003608 MIR domain
    IPB009460 Ryanodine Receptor TM 4-6
    IPB013333 Ryanodine receptor signature
    IPB013662 RyR and IP3R Homology associated


    UniProtKB/Swiss-Prot: RYR1_HUMAN, P21817
    Domain: The calcium release channel activity resides in the C-terminal region while the remaining part of the
    protein constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum (SR) and
    the T-tubule (By similarity)
    Similarity: Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily
    Similarity: Contains 3 B30.2/SPRY domains
    Similarity: Contains 5 MIR domains


    RYR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RYR1_HUMAN, P21817
    Function: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm
    and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated
    very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the
    cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote
    prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal
    muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By
    similarity)

         Genatlas biochemistry entry for RYR1:
    ryanodine receptor 1,controlling intracellular Ca2+ levels by releasing Ca2+ from the sarcoplasmic
    reticulum,expressed in skeletal and cardiac muscle,and involved in the control of cellular activities of B
    cells,triggered by the dehydrine receptor(s)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0005216ion channel activity ----
    GO:0005219ryanodine-sensitive calcium-release channel activity TAS19095005
    GO:0005245voltage-gated calcium channel activity ISS--
    GO:0005262calcium channel activity ISS--
         
    RYR1 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Ryr1):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  muscle  other  respiratory system  skeleton 

    RYR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RYR1: Ryr1tm1Alle Ryr1tm1Tno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RYR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RYR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RYR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RYR1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RYR1_HUMAN, P21817: Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane
    protein (Probable). Note=The number of predicted transmembrane domains varies between orthologs, but both
    N-terminus and C-terminus seem to be cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane4
    cytosol2
    extracellular2
    mitochondrion2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11206130
    GO:0005790smooth endoplasmic reticulum TAS2298749
    GO:0005886plasma membrane IDA11206130
    GO:0005887integral component of plasma membrane TAS2298749
    GO:0005938cell cortex IDA11206130

    RYR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RYR1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RYR1 (see all 9)
        Activation of PKA through GPCR
    PKA Signaling
    Netrin Signaling
    Presenilin-Mediated Signaling
    nNOS Signaling in Skeletal Muscle

    1 Cell Signaling Technology (CST) Pathway for RYR1
        Ca, cAMP and Lipid Signaling

    4 GeneGo (Thomson Reuters) Pathways for RYR1
        G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Signal transduction Calcium signaling

    2 BioSystems Pathways for RYR1
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell

    1 Reactome Pathway for RYR1
        Stimuli-sensing channels


    4 Kegg Pathways  (Kegg details for RYR1):
        Calcium signaling pathway
    Circadian entrainment
    Long-term depression
    Oxytocin signaling pathway


    RYR1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RYR1
    Interactions:

        GeneGlobe Interaction Network for RYR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RYR1 (P218171, 2, 3 ENSP000003526084) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191742, 3, ENSP000002440074MINT-8112747 I2D: score=3 STRING: ENSP00000244007
    H2AFZP0C0S52, 3MINT-19797 I2D: score=1 
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA19120137
    GO:0003151outflow tract morphogenesis ISS--
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ISS--
    GO:0006874cellular calcium ion homeostasis ----

    RYR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for RYR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (-)-Xestospongin CInhibits IP3-mediated Ca2+ release[88903-69-9]
    trans-Ned 19NAADP antagonist; inhibits Ca2+ release[1354235-96-3]
    Ionomycin calcium saltCalcium ionophore[56092-82-1]
    NAADP tetrasodium saltCa2+ mobilizing agent[5502-96-5]
    RyanodineCa2+ release inhibitor[15662-33-6]

    2 HMDB Compounds for RYR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 DrugBank Compounds for RYR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DantroleneDantrolene Sodium (see all 3)7261-97-4targetantagonist15023108 7488490 12167662 6704779 16945924 12666006 11752352 7362049 9924249
    CaffeineCafeina (see all 7)58-08-2target--17514358
    SuraminBayer 205 (see all 6)145-63-1targetagonist16056233

    9 IUPHAR Ligands for RYR1 (RyR1)    About this table
    LigandTypeActionAffinityPubmed IDs
    ATP
    ActivatorNone--
    ryanodine
    Channel blockerNone--
    suramin
    ActivatorNone--
    procaine
    Channel blockerNone--
    caffeine
    ActivatorNone--
    Ca2+
    AntagonistAntagonist--
    ruthenium red
    Channel blockerNone--
    Mg2+
    AntagonistAntagonist--
    dantrolene
    AntagonistAntagonist--

    Selected Novoseek inferred chemical compound relationships for RYR1 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 98.3 1193 11226332 (5), 12151923 (4), 18353852 (4), 19802526 (4) (see all 99)
    4-chloro-m-cresol 90.6 79 12761215 (10), 16737973 (7), 16601083 (7), 11990295 (3) (see all 23)
    dihydropyridine 88.3 124 11179064 (4), 16302848 (2), 16357209 (2), 18556650 (2) (see all 71)
    calcium 84 1057 19767002 (8), 11964231 (6), 11232598 (5), 11741831 (5) (see all 99)
    pcb 95 83.8 5 19337518 (1)
    caffeine 83.7 109 12151923 (3), 11477079 (3), 11990295 (3), 11360934 (2) (see all 66)
    cyclic adp-ribose 81.2 77 7826401 (4), 12966165 (3), 7925959 (3), 17190906 (2) (see all 28)
    inositol 1,4,5 trisphosphate 78.2 43 18174159 (2), 12921667 (2), 15160398 (1), 15212806 (1) (see all 37)
    dantrolene 77.3 32 12167662 (3), 11585849 (2), 16945924 (2), 15160398 (1) (see all 21)
    ryanodol 76.3 2 10871634 (1), 11331348 (1)

    1 PharmGKB related drug/compound annotation for RYR1 gene    About this table
    Drug/compound PharmGKB Annotation
    hmg coa reductase inhibitorsCA  



    RYR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RYR1 gene (2 alternative transcripts): 
    NM_000540.2  NM_001042723.1  

    Unigene Cluster for RYR1:

    Ryanodine receptor 1 (skeletal)
    Hs.466664  [show with all ESTs]
    Unigene Representative Sequence: NM_000540
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355481(uc002oiu.3) ENST00000359596(uc002oit.3) ENST00000594111
    ENST00000594335 ENST00000599547 ENST00000600337 ENST00000601514 ENST00000596431
    ENST00000593322 ENST00000593677 ENST00000360985(uc002oiv.1 uc010xuf.1)

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    Additional mRNA sequence: 

    AB209425.1 AF075460.1 AK293785.1 J05200.1 

    10 DOTS entries:

    DT.113052  DT.100019702  DT.121502810  DT.100748838  DT.121502805  DT.65286971  DT.75101790  DT.97788775 
    DT.40260655  DT.91978919 

    Selected AceView cDNA sequences (see all 107):

    BQ962760 BG830167 F31264 AF075460 F34300 F36856 BE764223 NM_000540 
    BM805728 BE764184 BQ185433 AA808825 CB129444 F21877 BQ189108 F15827 
    CA427848 F34519 F24310 J05200 BX283152 BF036839 BE764181 BE764241 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RYR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^
    SP1:                                                                          -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58a · 58b ^ 59 ^ 60 ^ 61a · 61b · 61c ^ 62 ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^ 70
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for RYR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RYR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTCCTGA
    RYR1 Expression
    About this image


    RYR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Larynx (Respiratory System)
    RYR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RYR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466664

    UniProtKB/Swiss-Prot: RYR1_HUMAN, P21817
    Tissue specificity: Skeletal muscle and brain (cerebellum and hippocampus)

        Custom PCR Arrays for RYR1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RYR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RYR1
    QuantiTect SYBR Green Assays in human, mouse, rat RYR1
    QuantiFast Probe-based Assays in human, mouse, rat RYR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RYR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ryr11 , 5 ryanodine receptor 1, skeletal muscle1, 5 88.23(n)1
    95.56(a)1
      7 (16.94 cM)5
    201901  NM_009109.21  NP_033135.21 
     290033405 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    85(a)
    84(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343427.1(594163-627241)
    GL343427.1(685880-727627)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133032 Transcribed sequence with strong similarity to protein more 85.53(n)    BX726845.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ryr1b6
    ryr1a6
    ryanodine receptor 1a (skeletal)
    76(a)
    76(a)
    many → 1
    many → 1
    18(33835785-34021041) ENSDARG00000023797
    10(34434994-34568619) ENSDARG00000011422
    wheat
    (Triticum aestivum)
    Liliopsida Ta.92692 Triticum aestivum transcribed sequence with weak similarity more 72.17(n)    BQ838200.1 


    ENSEMBL Gene Tree for RYR1 (if available)
    TreeFam Gene Tree for RYR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for RYR1 gene
    RYR22  ITPR32  ITPR22  ITPR12  RYR32  
    3 SIMAP similar genes for RYR1 using alignment to 11 protein entries:     RYR1_HUMAN (see all proteins):
    RYR3    RyR    RYR2

    RYR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RYR1 (see all 4900)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121053811,2,,4
    CMalignant hyperthermia 1 (MHS1)4 --39113181(+) GACTGC/GGAAGG 4 A G mis10--------
    rs1178866181,2,,4
    CMalignant hyperthermia 1 (MHS1)4 untested139133979(+) TACGAC/G/TGGGCT 4 D E mis12EA EU 1401
    rs1416466421,2,,4
    C,FCentral core disease of muscle (CCD)4 untested139135793(+) ATGCAC/G/TGAGAC 4 H Q mis11NA 4552
    rs1472138951,2,,4
    C,FMalignant hyperthermia 1 (MHS1)4 untested139138756(+) CGTCAA/GCGGTG 4 N S mis12Minor allele frequency- G:0.00NA EU 5869
    rs289333961,2,,4
    CMalignant hyperthermia 1 (MHS1)4 pathogenic139139512(+) CGGACA/G/TCTGTG 6 H R L mis1 ese30--------
    rs289333971,2,,4
    CMalignant hyperthermia 1 (MHS1)4 other139140169(+) TCCTCC/TGCTCC 4 R C mis1 ese30--------
    rs351805841,2,,4
    C,FMalignant hyperthermia 1 (MHS1)4 other139144843(+) GAAGAC/GCCACC 4 T S mis16Minor allele frequency- G:0.01NA WA EU 5941
    rs1379321991,2,,4
    C,FCentral core disease of muscle (CCD)4 untested139158842(+) GCTGCG/ACAAGA 4 /H /R mis11Minor allele frequency- A:0.00NA 4510
    rs1439878571,2,,4
    C,FCentral core disease of muscle (CCD)4 untested139165043(+) GACCCG/ATTACG 4 /H /R mis12Minor allele frequency- A:0.00NA EU 5619
    rs1471363391,2,,4
    C,FCentral core disease of muscle (CCD)4 untested139183101(+) CTTCTA/GCTGGT 4 Y C mis11Minor allele frequency- G:0.00NA 4548

    HapMap Linkage Disequilibrium report for RYR1 (38924339 - 39078204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RYR1 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664482CNV Deletion23128226
    esv2718533CNV Deletion23290073
    esv2718534CNV Deletion23290073
    nsv513527CNV Insertion21212237
    nsv513526CNV Insertion21212237
    esv1437952CNV Insertion17803354
    esv2452159CNV Insertion19546169
    nsv138081CNV Insertion16902084
    nsv2479CNV Insertion18451855
    dgv3858n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): RYR1
    Locus Specific Mutation Databases (LSDB): RYR1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RYR1
    DNA2.0 Custom Variant and Variant Library Synthesis for RYR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 180901   
    OMIM disorders: 145600  117000  255320  
    UniProtKB/Swiss-Prot: RYR1_HUMAN, P21817
  • Malignant hyperthermia 1 (MHS1) [MIM:145600]: Autosomal dominant pharmacogenetic disorder of skeletal
    muscle and is one of the main causes of death due to anesthesia. In susceptible people, an MH episode can be
    triggered by all commonly used inhalational anesthetics such as halothane and by depolarizing muscle relaxants
    such as succinylcholine. The clinical features of the myopathy are hyperthermia, accelerated muscle metabolism,
    contractures, metabolic acidosis, tachycardia and death, if not treated with the postsynaptic muscle relaxant,
    dantrolene. Susceptibility to MH can be determined with the 'in vitro' contracture test (IVCT): observing the
    magnitude of contractures induced in strips of muscle tissue by caffeine alone and halothane alone. Patients with
    normal response are MH normal (MHN), those with abnormal response to caffeine alone or halothane alone are MH
    equivocal (MHE(C) and MHE(H) respectively). Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Central core disease of muscle (CCD) [MIM:117000]: Autosomal dominant congenital myopathy, but a severe
    autosomal recessive form also exists. Both clinical and histological variability is observed. Affected
    individuals typically display hypotonia and proximal muscle weakness in infancy, leading to the delay of motor
    milestones. The clinical course of the disorder is usually slow or nonprogressive in adulthood, and the severity
    of the symptoms may vary from normal to significant muscle weakness. Microscopic examination of CCD-affected
    skeletal muscle reveals a predominance of type I fibers containing amorphous-looking areas (cores) that do not
    stain with oxidative and phosphorylase histochemical techniques. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Multiminicore disease with external ophthalmoplegia (MMDO) [MIM:255320]: Clinically heterogeneous
    neuromuscular disorder. General features include neonatal hypotonia, delayed motor development, and generalized
    muscle weakness and amyotrophy, which may progress slowly or remain stable. Muscle biopsy shows multiple, poorly
    circumscribed, short areas of sarcomere disorganization and mitochondria depletion (areas termed minicores) in
    most muscle fibers. Typically, no dystrophic signs, such as muscle fiber necrosis or regeneration or significant
    endomysial fibrosis, are present in multiminicore disease. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Myopathy, congenital, with fiber-type disproportion (CFTD) [MIM:255310]: A genetically heterogeneous
    disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal
    muscle biopsy. However, these findings are not specific and can be found in many different myopathic and
    neuropathic conditions. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course.
    Patients display severe hypotonia and respiratory distress at birth. Unlike other congenital myopathies, the
    health status constantly improves and patients are minimally affected at adulthood

  • Selected diseases for RYR1 (see all 61):    
    About MalaCards
    malignant hyperthermia    king denborough syndrome    ryr1-related multiminicore disease    malignant hyperthermia susceptibility
    ryr1-related congenital fiber-type disproportion    ryr1-related malignant hyperthermia susceptibility    benign samaritan congenital myopathy    congenital neuromuscular disease with uniform type 1 fiber
    minicore myopathy with external ophthalmoplegia    malignant hyperthermia susceptibility type 1    central core myopathy    multiminicore disease
    neuromuscular disease    rod myopathy    myopathy congenital    centronuclear myopathy
    ophthalmoplegia    hypokalemic periodic paralysis    myasthenia gravis    3-methylglutaconic aciduria

    4 diseases from the University of Copenhagen DISEASES database for RYR1:
    Malignant hyperthermia     Myopathy     Thymoma     Neuropathy

    RYR1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for RYR1 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    central core disease 96.4 114 12565913 (4), 17538032 (2), 12883401 (2), 11741831 (2) (see all 65)
    myopathy, congenital 86.4 20 17483490 (2), 11274444 (1), 14670767 (1), 15564033 (1) (see all 13)
    ventricular tachycardia, catecholaminergic polymorphic 75 7 15951021 (1), 19167631 (1), 18006483 (1), 18362417 (1) (see all 7)
    muscle contracture 71 2 1341035 (1), 19807743 (1)
    contracture 70.7 14 12151923 (3), 18564801 (2), 9334205 (1), 7633940 (1) (see all 6)
    myopathy 69.7 45 16940308 (3), 17190947 (3), 17033962 (3), 18171678 (2) (see all 24)
    myasthenia gravis 59.8 22 8021674 (5), 7499495 (1), 9397486 (1), 17536276 (1) (see all 13)
    thymoma 56.5 48 7499495 (5), 10896269 (5), 11182151 (4), 9736058 (4) (see all 17)
    hypokalemic periodic paralysis 49.5 2 9307247 (1), 15336973 (1)
    myopathies nemaline 48.4 3 12565913 (1), 15336973 (1), 18312400 (1)

    GeneTests: RYR1
    GeneReviews: RYR1
    Genetic Association Database (GAD): RYR1
    Human Genome Epidemiology (HuGE) Navigator: RYR1 (10 documents)

    Export disorders for RYR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RYR1 gene, integrated from 10 sources (see all 888) (see top 10):
    (articles sorted by number of sources associating them with RYR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Increasing the number of diagnostic mutations in malignant hyperthermia. (PubMed id 19191329)1, 2, 4, 9 Levano S....Girard T. (Hum. Mutat. 2009)
    2. The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia. (PubMed id 7881417)1, 2, 4, 9 Phillips M.S....McLennan D.H. (Hum. Mol. Genet. 1994)
    3. Malignant hyperthermia in North America: genetic screening of the three hot spots in the type I ryanodine receptor gene. (PubMed id 15448513)1, 2, 4 Sei Y.... Muldoon S.M. (Anesthesiology 2004)
    4. Mutation screening in the ryanodine receptor 1 gene (RYR1) in patients susceptible to malignant hyperthermia who show definite IVCT results: identification of three novel mutations. (PubMed id 12059893)1, 2, 4 Rueffert H.... Froster U.G. (Acta Anaesthesiol. Scand. 2002)
    5. Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores. (PubMed id 7829078)1, 2, 4 Quane K.A....McCarthy T.V. (Genomics 1994)
    6. Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis. (PubMed id 11741831)2, 4, 9 Tilgen N....Treves S. (Hum. Mol. Genet. 2001)
    7. Null mutations causing depletion of the type 1 ryanodine receptor (RYR1) are commonly associated with recessive structural congenital myopathies with cores. (PubMed id 18253926)1, 2, 9 Monnier N.... Lunardi J. (Hum. Mutat. 2008)
    8. Genetic variation in RYR1 and malignant hyperthermia phenotypes. (PubMed id 19648156)1, 4, 9 Carpenter D....Hopkins P.M. (Br J Anaesth 2009)
    9. Detection of a novel ryanodine receptor subtype 1 mutation (R328W) in a malignant hyperthermia family by sequencing of a leukocyte transcript. (PubMed id 12883402)2, 4, 9 Loke J.C.P....MacLennan D.H. (Anesthesiology 2003)
    10. Familial and sporadic forms of central core disease are associated with mutations in the C-terminal domain of the skeletal muscle ryanodine receptor. (PubMed id 11709545)1, 2, 9 Monnier N.... Lunardi J. (Hum. Mol. Genet. 2001)
    11. Central core disease is due to RYR1 mutations in more than 90% of patients. (PubMed id 16621918)1, 3, 9 Wu S....Nishino I. (Brain 2006)
    12. Novel mutations in C-terminal channel region of the ryanodine receptor in malignant hyperthermia patients. (PubMed id 11928716)1, 2, 9 Oyamada H.... Iino M. (Jpn. J. Pharmacol. 2002)
    13. Single-amino-acid deletion in the RYR1 gene, associated with malignant hyperthermia susceptibility and unusual contraction phenotype. (PubMed id 11389482)2, 4, 9 Sambuughin N.... Nelson T.E. (Am. J. Hum. Genet. 2001)
    14. Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia. (PubMed id 1354642)1, 2, 9 Gillard E.F.... McLennan D.H. (Genomics 1992)
    15. S100A1 and calmodulin compete for the same binding site on ryanodine receptor. (PubMed id 18650434)1, 2, 9 Wright N.T....Weber D.J. (J. Biol. Chem. 2008)
    16. Novel RYR1 missense mutation causes core rod myopathy. (PubMed id 18312400)1, 2, 9 von der Hagen M.... Kaindl A.M. (Eur. J. Neurol. 2008)
    17. Central core disease due to recessive mutations in RYR1 gene: is it more common than described? (PubMed id 17226826)1, 2, 9 Kossugue P.M.... Vainzof M. (Muscle Nerve 2007)
    18. Minicore myopathy with ophthalmoplegia caused by mutations in the ryanodine receptor type 1 gene. (PubMed id 16380615)1, 2, 9 Jungbluth H.... Muntoni F. (Neurology 2005)
    19. Adult onset multi/minicore myopathy associated with a mutation in the RYR1 gene. (PubMed id 14999498)1, 4, 9 Pietrini V....Sorrentino V. (J. Neurol. 2004)
    20. RYR1 mutations in UK central core disease patients: more than just the C-terminal transmembrane region of the RYR1 gene. (PubMed id 14985404)1, 2, 9 Shepherd S.... Robinson R. (J. Med. Genet. 2004)
    21. Dominant and recessive central core disease associated with RYR1 mutations and fetal akinesia. (PubMed id 12937085)2, 4, 9 Romero N.B.... Fardeau M. (Brain 2003)
    22. Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene. (PubMed id 12565913)1, 2, 9 Davis M.R.... Laing N.G. (Neuromuscul. Disord. 2003)
    23. Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO. (PubMed id 11562475)1, 2, 9 Sun J.... Meissner G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    24. Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation. (PubMed id 9497245)1, 2, 9 Manning B.M....McCarthy T.V. (Am. J. Hum. Genet. 1998)
    25. Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. (PubMed id 9607712)1, 2, 9 Martin C.... Ashley R.H. (Neuroscience 1998)
    26. Identification of heterozygous and homozygous individuals with the novel RYR1 mutation Cys35Arg in a large kindred. (PubMed id 9066328)1, 2, 9 Lynch P.J.... Lunardi J. (Anesthesiology 1997)
    27. Detection of a novel mutation at amino acid position 614 in the ryanodine receptor in malignant hyperthermia. (PubMed id 9389851)1, 2, 9 Quane K.A.... McCarthy T.V. (Br. J. Anaesth. 1997)
    28. The structural organization of the human skeletal muscle ryanodine receptor (RYR1) gene. (PubMed id 8661021)1, 2, 9 Phillips M.S.... McLennan D.H. (Genomics 1996)
    29. Detection of a novel RYR1 mutation in four malignant hyperthermia pedigrees. (PubMed id 7849712)1, 2, 9 Keating K.E....McCarthy T.V. (Hum. Mol. Genet. 1994)
    30. Samaritan myopathy, an ultimately benign congenital myopathy, is caused by a RYR1 mutation. (PubMed id 22752422)1, 2 Bohm J.... Laporte J. (Acta Neuropathol. 2012)
    31. Dominant and recessive RYR1 mutations in adults with core lesions and mild muscle symptoms. (PubMed id 21674524)1, 2 Duarte S.T.... Evangelista T. (Muscle Nerve 2011)
    32. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    33. Recessive mutations in RYR1 are a common cause of congenital fiber type disproportion. (PubMed id 20583297)1, 2 Clarke N.F.... North K.N. (Hum. Mutat. 2010)
    34. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    35. Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease. (PubMed id 20142353)1, 2 Vukcevic M.... Treves S. (Anesth. Analg. 2010)
    36. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    37. Analysis of RYR1 haplotype profile in patients with malignant hyperthermia. (PubMed id 18945287)1, 4 Carpenter D....Shaw M.A. (Ann. Hum. Genet. 2009)
    38. Frequency and localization of mutations in the 106 exons of the RYR1 gene in 50 individuals with malignant hyperthermia. (PubMed id 16835904)1, 4 Galli L....Sorrentino V. (Hum. Mutat. 2006)
    39. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    40. Multiminicore disease in a family susceptible to malignant hyperthermia: histology, in vitro contracture tests, and genetic characterization. (PubMed id 14732627)2, 4 Guis S....Pellissier J.-F. (Arch. Neurol. 2004)
    41. Autosomal recessive inheritance of RYR1 mutations in a congenital myopathy with cores. (PubMed id 12136074)1, 2 Jungbluth H.... Muntoni F. (Neurology 2002)
    42. Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees. (PubMed id 12066726)1, 2 Davis M.... Stowell K. (Br. J. Anaesth. 2002)
    43. A recessive form of central core disease, transiently presenting as multi-minicore disease, is associated with a homozygous mutation in the ryanodine receptor type 1 gene. (PubMed id 12112081)1, 2 Ferreiro A.... Guicheney P. (Ann. Neurol. 2002)
    44. Novel mutation in the RYR1 gene (R2454C) in a patient with malignant hyperthermia. (PubMed id 10612851)1, 2 Gencik M.... Epplen J.T. (Hum. Mutat. 2000)
    45. Screening of the ryanodine receptor gene in 105 malignant hyperthermia families: novel mutations and concordance with the in vitro contracture test. (PubMed id 10484775)1, 2 Brandt A....Lehmann-Horn F. (Hum. Mol. Genet. 1999)
    46. Mutation screening of the RYR1 gene and identification of two novel mutations in Italian malignant hyperthermia families. (PubMed id 10051009)1, 2 Barone V.... Sorrentino V. (J. Med. Genet. 1999)
    47. Novel mutations at a CpG dinucleotide in the ryanodine receptor in malignant hyperthermia. (PubMed id 9450902)1, 2 Manning B.M.... McCarthy T.V. (Hum. Mutat. 1998)
    48. Detection of a novel mutation in the ryanodine receptor gene in an Irish malignant hyperthermia pedigree: correlation of the IVCT response with the affected and unaffected haplotypes. (PubMed id 9138151)1, 2 Keating K.E.... McCarthy T.V. (J. Med. Genet. 1997)
    49. Ryanodine receptor gene point mutation and malignant hyperthermia susceptibility. (PubMed id 7751854)1, 2 Moroni I.... Scarlato G. (J. Neurol. 1995)
    50. Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle. (PubMed id 7556644)1, 2 Lynn S.... Gillespie J.I. (FEBS Lett. 1995)
    51. Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies. (PubMed id 8012359)1, 2 Quane K.A.... McCarthy T.V. (Hum. Mol. Genet. 1994)
    52. A mutation in the human ryanodine receptor gene associated with central core disease. (PubMed id 8220422)1, 2 Zhang Y.... McLennan D.H. (Nat. Genet. 1993)
    53. Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia. (PubMed id 8220423)1, 2 Quane K.A.... McCarthy T.V. (Nat. Genet. 1993)
    54. Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia. (PubMed id 1639409)1, 2 Otsu K.... McLennan D.H. (Genomics 1992)
    55. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. (PubMed id 1862346)1, 3 Fujii J....MacLennan D.H. (Science 1991)
    56. A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia. (PubMed id 1774074)1, 2 Gillard E.F.... MacLennan D.H. (Genomics 1991)
    57. Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. (PubMed id 2298749)1, 2 Zorzato F.... Maclennan D.H. (J. Biol. Chem. 1990)
    58. Ryanodine receptor type-1 (RyR1) expression and protein S-nitrosylation pattern in human soleus myofibres following bed rest and exercise countermeasure. (PubMed id 18283481)1, 9 Salanova M....Blottner D. (Histochem. Cell Biol. 2008)
    59. Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors). (PubMed id 12213830)1, 9 Xiao B....Chen S.R. (J. Biol. Chem. 2002)
    60. Ryanodine receptor oligomeric interaction: identification of a putative binding region. (PubMed id 14722100)1, 9 Blayney L.M....Lai F.A. (J. Biol. Chem. 2004)
    61. Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. (PubMed id 12709444)1, 9 Ruehr M.L....Bond M. (J. Biol. Chem. 2003)
    62. Postmortem molecular screening for mutations in ryanodine receptor type 1 (RYR1) gene in psychiatric patients suspected of having died of neuroleptic malignant syndrome. (PubMed id 19931341)1, 9 Sato T....Suzuki K. (Forensic Sci. Int. 2010)
    63. FAPrster resonance energy transfer measurements of ryanodine receptor type 1 structure using a novel site-specific labeling method. (PubMed id 19823671)1, 9 Fessenden J.D. (PLoS ONE 2009)
    64. Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. (PubMed id 16958053)1, 9 Lyfenko A.D....Dirksen R.T. (Hum. Mutat. 2007)
    65. Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+. (PubMed id 17259277)1, 9 Kong H....Chen S.R. (Biophys. J. 2007)
    66. Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release. (PubMed id 15175001)1, 9 Du G.G....MacLennan D.H. (Biochem. J. 2004)
    67. Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. (PubMed id 14638677)1, 9 Lee J.M....Kim D.H. (J. Biol. Chem. 2004)
    68. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. (PubMed id 12167662)7, 9 Paul-Pletzer K....Parness J. (J. Biol. Chem. 2002)
    69. Functional studies of RYR1 mutations in the skeletal muscle ryanodine receptor using human RYR1 complementary DNA. (PubMed id 20461000)1, 9 Sato K....Stowell K.M. (Anesthesiology 2010)
    70. Identification of genetic mutations in Australian malignant hyperthermia families using sequencing of RYR1 hotspots. (PubMed id 18564801)1, 9 Gillies R.L....Du Sart D. (Anaesth Intensive Care 2008)
    71. Centronuclear myopathy due to a de novo dominant mutation in the skeletal muscle ryanodine receptor (RYR1) gene. (PubMed id 17376685)1, 9 Jungbluth H....Muntoni F. (Neuromuscul. Disord. 2007)
    72. Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1. (PubMed id 17071618)1, 9 Aracena-Parks P....Hamilton S.L. (J. Biol. Chem. 2006)
    73. Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies. (PubMed id 17033962)1, 9 Zhou H....Muntoni F. (Am. J. Hum. Genet. 2006)
    74. North American malignant hyperthermia population: screening of the ryanodine receptor gene and identification of novel mutations. (PubMed id 11575529)2, 9 Sambuughin N.... Muldoon S.M. (Anesthesiology 2001)
    75. Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes. (PubMed id 19191333)1, 9 Zullo A....Carsana A. (Hum. Mutat. 2009)
    76. Functional analysis of ryanodine receptor type 1 p.R2508C mutation in exon 47. (PubMed id 19685112)1, 9 Migita T....Kawamoto M. (J Anesth 2009)
    77. Congenital neuromuscular disease with uniform type 1 fiber and RYR1 mutation. (PubMed id 17538032)1, 9 Sato I....Nishino I. (Neurology 2008)
    78. Mutations in the RYR1 gene in Italian patients at risk for malignant hyperthermia: evidence for a cluster of novel mutations in the C- terminal region. (PubMed id 12208234)2, 9 Galli L....Sorrentino V. (Cell Calcium 2002)
    79. Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle. (PubMed id 12496092)1, 9 Protasi F....Allen P.D. (Biophys. J. 2002)
    80. Expression of the ryanodine receptor isoforms in immune cells. (PubMed id 11673493)1, 9 Hosoi E....Sei Y. (J. Immunol. 2001)
    81. Skeletal muscle type ryanodine receptor is involved in calcium signaling in human B lymphocytes. (PubMed id 10026226)1, 9 Sei Y.... Basile A.S. (J. Biol. Chem. 1999)
    82. Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels. (PubMed id 18618700)1, 9 Meissner G....Tripathy A. (Proteins 2009)
    83. Muscle imaging in dominant core myopathies linked or unlinked to the ryanodine receptor 1 gene. (PubMed id 17190947)1, 9 Fischer D....Romero N.B. (Neurology 2006)
    84. Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1. (PubMed id 15972723)1, 9 Kimura T....Sakoda S. (Hum. Mol. Genet. 2005)
    85. Ryanodine receptor 1 mutations, dysregulation of calcium homeostasis and neuromuscular disorders. (PubMed id 16084090)1, 9 Treves S....Zorzato F. (Neuromuscul. Disord. 2005)
    86. Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease. (PubMed id 15299003)1, 9 Ducreux S....Treves S. (J. Biol. Chem. 2004)
    87. Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. (PubMed id 12566385)2, 9 Zorzato F.... Treves S. (Hum. Mol. Genet. 2003)
    88. FKBP12 binding modulates ryanodine receptor channel gating. (PubMed id 11279144)1, 9 Gaburjakova M....Marks A.R. (J. Biol. Chem. 2001)
    89. MCF-7 breast carcinoma cells express ryanodine receptor type 1: functional characterization and subcellular localization. (PubMed id 19082546)1, 9 SaldaA+a C....Morales-Tlalpan V. (Mol. Cell. Biochem. 2009)
    90. Late-onset axial myopathy with cores due to a novel heterozygous dominant mutation in the skeletal muscle ryanodine receptor (RYR1) gene. (PubMed id 19303294)1, 9 Jungbluth H....Muntoni F. (Neuromuscul. Disord. 2009)
    91. Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia. (PubMed id 18212565)1, 9 Anderson A.A....Stowell K.M. (Anesthesiology 2008)
    92. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. (PubMed id 16945924)7, 9 Zhao X....Ma J. (J. Biol. Chem. 2006)
    93. Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. (PubMed id 16284304)1, 9 Chelu M.G....Hamilton S.L. (FASEB J. 2006)
    94. Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1). (PubMed id 15226293)1, 9 Du G.G....MacLennan D.H. (J. Biol. Chem. 2004)
    95. Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala. (PubMed id 14641996)1, 9 Wehner M....Olthoff D. (Genet. Test. 2003)
    96. Scanning for mutations of the ryanodine receptor (RYR1) gene by denaturing HPLC: detection of three novel malignant hyperthermia alleles. (PubMed id 12709367)2, 9 Tammaro A.... Nigro V. (Clin. Chem. 2003)
    97. A novel ryanodine receptor mutation and genotype-phenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree. (PubMed id 10888602)2, 9 Brown R.L.... Stowell K.M. (Hum. Mol. Genet. 2000)
    98. Functional characterization of a distinct ryanodine receptor mutation in human malignant hyperthermia-susceptible muscle. (PubMed id 9030597)1, 9 Richter M....Herrmann-Frank A. (J. Biol. Chem. 1997)
    99. Mutation screening of the RYR1-cDNA from peripheral B-lymphocytes in 15 Swedish malignant hyperthermia index cases. (PubMed id 19346234)1, 9 Broman M....MA1ller C.R. (Br J Anaesth 2009)
    100. The ryanodine receptor type 1 gene variants in African American men with exertional rhabdomyolysis and malignant hyperthermia susceptibility. (PubMed id 19807743)1, 9 Sambuughin N....Muldoon S. (Clin. Genet. 2009)
    101. A RYR1 mutation associated with recessive congenital myopathy and dominant malignant hyperthermia in Asian families. (PubMed id 19645060)1, 9 Carpenter D....Hopkins P.M. (amp 2009)
    102. A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity. (PubMed id 19027160)1, 9 Ghassemi F....Treves S. (Cell Calcium 2009)
    103. Multigenerational Brazilian family with malignant hyperthermia and a novel mutation in the RYR1 gene. (PubMed id 19918671)1, 9 Matos A.R....Sudo R.T. (Braz. J. Med. Biol. Res. 2009)
    104. Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. (PubMed id 18505726)1, 9 Jiang D....Chen S.R. (J. Biol. Chem. 2008)
    105. Identification of functional type 1 ryanodine receptors in human dendritic cells. (PubMed id 17707769)1, 9 Uemura Y....Matsushita S. (Biochem. Biophys. Res. Commun. 2007)
    106. Inheritance of a novel RYR1 mutation in a family with myotonic dystrophy type 1. (PubMed id 17204054)2, 9 Gambelli S.... Dotti M.T. (Clin. Genet. 2007)
    107. Functional properties of ryanodine receptors carrying three amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalized lymphocytes. (PubMed id 16372898)1, 9 Ducreux S....Treves S. (Biochem. J. 2006)
    108. Two rings of negative charges in the cytosolic vestibule of type-1 ryanodine receptor modulate ion fluxes. (PubMed id 16239337)1, 9 Xu L....Meissner G. (Biophys. J. 2006)
    109. Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility. (PubMed id 16163667)2, 9 Monnier N.... Lunardi J. (Hum. Mutat. 2005)
    110. Ca2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations. (PubMed id 15689621)1, 9 Brini M....Carafoli E. (J. Biol. Chem. 2005)
    111. Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. (PubMed id 16056233)7, 9 Wolner I....Hohenegger M. (Br. J. Pharmacol. 2005)
    112. Magnetic resonance imaging of muscle in congenital myopathies associated with RYR1 mutations. (PubMed id 15564033)1, 9 Jungbluth H....Muntoni F. (Neuromuscul. Disord. 2004)
    113. Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. (PubMed id 14660561)1, 9 Ward C.W....Schneider M.F. (J. Biol. Chem. 2004)
    114. Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion. (PubMed id 15033925)1, 9 Johnson J.D....Polonsky K.S. (FASEB J. 2004)
    115. A noncontiguous, intersubunit binding site for calmodulin on the skeletal muscle Ca2+ release channel. (PubMed id 12509414)1, 9 Zhang H....Hamilton S.L. (J. Biol. Chem. 2003)
    116. Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel. (PubMed id 12509428)1, 9 Sun J....Meissner G. (J. Biol. Chem. 2003)
    117. Screening for mutations in the RYR1 gene in families with malignant hyperthermia. (PubMed id 14500992)1, 9 Muniz V.P....Vainzof M. (J. Mol. Neurosci. 2003)
    118. Central core disease: clinical, pathological, and genetic features. (PubMed id 14670767)2, 9 Quinlivan R.M.... Sewry C.A. (Arch. Dis. Child. 2003)
    119. Homer regulates gain of ryanodine receptor type 1 channel complex. (PubMed id 12223488)1, 9 Feng W....Pessah I.N. (J. Biol. Chem. 2002)
    120. Presence of two different genetic traits in malignant hyperthermia families: implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility. (PubMed id 12411788)2, 9 Monnier N.... Lunardi J. (Anesthesiology 2002)
    121. FKBP binding characteristics of cardiac microsomes from diverse vertebrates. (PubMed id 11237759)1, 9 Jeyakumar L.H....Fleischer S. (Biochem. Biophys. Res. Commun. 2001)
    122. Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures. (PubMed id 11206130)1, 9 Tanaka H....Mizusawa H. (J. Muscle Res. Cell. Motil. 2000)
    123. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. (PubMed id 10212196)1, 9 Groh S....Ronjat M. (J. Biol. Chem. 1999)
    124. Interaction of triadin with histidine-rich Ca(2+)-binding protein at the triadic junction in skeletal muscle fibers. (PubMed id 10531621)1, 9 Sacchetto R....Margreth A. (J. Muscle Res. Cell. Motil. 1999)
    125. Functional characterization of 2 known ryanodine receptor mutations causing malignant hyperthermia. (PubMed id 24361844)1 Schiemann A.H....Stowell K.M. (Anesth. Analg. 2014)
    126. Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis. (PubMed id 23628358)1 Dlamini N....Jungbluth H. (Neuromuscul. Disord. 2013)
    127. Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. (PubMed id 23183335)1 Kraeva N....Riazi S. (Neuromuscul. Disord. 2013)
    128. Congenital myopathy with focal loss of cross-striations revisited. (PubMed id 23127960)1 Voermans N.C....de Visser M. (Neuromuscul. Disord. 2013)
    129. RYR1 Mutations as a Cause of Ophthalmoplegia, Facial Weakness, and Malignant Hyperthermia. (PubMed id 24091937)1 Shaaban S....Engle E.C. (JAMA Ophthalmol 2013)
    130. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. (PubMed id 23788249)1 Green R.C....Biesecker L.G. (Genet. Med. 2013)
    131. Clinical features and ryanodine receptor type 1 gene mutation analysis in a Chinese family with central core disease. (PubMed id 22550088)1 Chang X....Qin J. (J. Child Neurol. 2013)
    132. Severe congenital RYR1-associated myopathy: the expanding clinicopathologic and genetic spectrum. (PubMed id 23553484)1 Bharucha-Goebel D.X....BAPnnemann C.G. (Neurology 2013)
    133. Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations. (PubMed id 23476141)1 Carsana A. (ScientificWorldJournal 2013)
    134. N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteins. (PubMed id 23585572)1 Girgenrath T....Fessenden J.D. (J. Biol. Chem. 2013)
    135. Exon skipping as a therapeutic strategy applied to an RYR1 mutation with pseudo-exon inclusion causing a severe core myopathy. (PubMed id 23805838)1 Rendu J....Marty I. (Hum. Gene Ther. 2013)
    136. Ryanodine receptor type 1 gene variants in the malignant hyperthermia-susceptible population of the United States. (PubMed id 23558838)1 Brandom B.W....Muldoon S.M. (Anesth. Analg. 2013)
    137. Variable myopathic presentation in a single family with novel skeletal RYR1 mutation. (PubMed id 23894444)1 Attali R....Nevo Y. (PLoS ONE 2013)
    138. A novel late-onset axial myopathy associated with mutations in the skeletal muscle ryanodine receptor (RYR1) gene. (PubMed id 23329375)1 LA...Jungbluth H. (J. Neurol. 2013)
    139. Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families. (PubMed id 24013571)1 Kim J.H....Hopkins P.M. (Anesthesiology 2013)
    140. Clinical and genetic findings in a large cohort of patients with ryanodine receptor 1 gene-associated myopathies. (PubMed id 22473935)1 Klein A....Muntoni F. (Hum. Mutat. 2012)
    141. 3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1 activator, not suitable for the diagnosis of malignant hyperthermia susceptibility. (PubMed id 22480578)1 Lacava C....Weigl L.G. (Pharmacol. Res. 2012)
    142. A study of a family with the skeletal muscle RYR1 mutation (c.7354C&gt;T) associated with central core myopathy and malignant hyperthermia susceptibility. (PubMed id 22030266)1 Taylor A....Lotery A.J. (J Clin Neurosci 2012)
    143. FRET-based localization of fluorescent protein insertions within the ryanodine receptor type 1. (PubMed id 22719904)1 Raina S.A....Fessenden J.D. (PLoS ONE 2012)
    144. Intense resistance exercise induces early and transient increases in ryanodine receptor 1 phosphorylation in human skeletal muscle. (PubMed id 23173055)1 Gehlert S....Suhr F. (PLoS ONE 2012)
    145. Novel double and single ryanodine receptor 1 variants in two Austrian malignant hyperthermia families. (PubMed id 22415532)1 Kaufmann A....Weigl L.G. (Anesth. Analg. 2012)
    146. Characterization of the molecular architecture of human caveolin-3 and interaction with the skeletal muscle ryanodine receptor. (PubMed id 23071107)1 Whiteley G....Kitmitto A. (J. Biol. Chem. 2012)
    147. Identification of ryanodine receptor isoforms in prostate DU-145, LNCaP, and PWR-1E cells. (PubMed id 22846571)1 Kobylewski S.E....Eckhert C.D. (Biochem. Biophys. Res. Commun. 2012)
    148. Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis. (PubMed id 21881589)1 Denda S....Denda M. (J. Invest. Dermatol. 2012)
    149. Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. (PubMed id 21828061)1 Hong K.W....Oh B. (Eur. Heart J. 2012)
    150. Variable phenotype of del45-55 Becker patients correlated with nNOSI1 mislocalization and RYR1 hypernitrosylation. (PubMed id 22589245)1 Gentil C....PiActri-Rouxel F. (Hum. Mol. Genet. 2012)
    151. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    152. Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. (PubMed id 22100703)1 Wen H.... Park S. (Arch. Biochem. Biophys. 2012)
    153. Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes. (PubMed id 22948152)1 Thakur P....Fomina A.F. (J. Biol. Chem. 2012)
    154. Search for genetic variants in the ryanodine receptor 1 gene in patients with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. (PubMed id 21503806)1 Rueffert H....Meixensberger J. (Neurocrit Care 2011)
    155. Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population. (PubMed id 21455645)1 Kraeva N....Maclennan D.H. (Can J Anaesth 2011)
    156. Clinical utility gene card for: malignant hyperthermia. (PubMed id 21248738)1 Rosenberg H. and Rueffert H. (Eur. J. Hum. Genet. 2011)
    157. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    158. Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP). (PubMed id 21454501)1 Ryan T....Gramolini A.O. (J. Biol. Chem. 2011)
    159. Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers. (PubMed id 20952238)1 Matsusue A....Kubo S. (Leg Med (Tokyo) 2011)
    160. Mutated p.4894 RyR1 function related to malignant hyperthermia and congenital neuromuscular disease with uniform type 1 fiber (CNMDU1). (PubMed id 21926372)1 Haraki T....Kawamoto M. (Anesth. Analg. 2011)
    161. Screening of the ryanodine 1 gene for malignant hyperthermia causative mutations by high resolution melt curve analysis. (PubMed id 21965348)1 Broman M....MA1ller C. (Anesth. Analg. 2011)
    162. Central core myopathy with RYR1 mutation masks 5q spinal muscular atrophy. (PubMed id 20452790)1 Pandey R....Quinlivan R. (Eur. J. Paediatr. Neurol. 2011)
    163. Prevalence of congenital myopathies in a representative pediatric united states population. (PubMed id 22028225)1 Amburgey K....Dowling J.J. (Ann. Neurol. 2011)
    164. Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. (PubMed id 21918424)1 Groom L....Dirksen R.T. (Anesthesiology 2011)
    165. Postpacing abnormal repolarization in catecholaminergic polymorphic ventricular tachycardia associated with a mutation in the cardiac ryanodine receptor gene. (PubMed id 21699856)1 Nof E....Glikson M. (Heart Rhythm 2011)
    166. Recessive RYR1 mutations cause unusual congenital myopathy with prominent nuclear internalization and large areas of myofibrillar disorganization. (PubMed id 21062345)1 Bevilacqua J.A....Romero N.B. (Neuropathol. Appl. Neurobiol. 2011)
    167. Novel missense mutations and unexpected multiple changes of RYR1 gene in 75 malignant hyperthermia families. (PubMed id 20681998)1 Tammaro A....Nigro V. (Clin. Genet. 2011)
    168. The elusive role of the SPRY2 domain in RyR1. (PubMed id 21239886)1 Tae H....Dulhunty A. (Channels (Austin) 2011)
    169. King-Denborough syndrome with and without mutations in the skeletal muscle ryanodine receptor (RYR1) gene. (PubMed id 21514828)1 Dowling J.J....Jungbluth H. (Neuromuscul. Disord. 2011)
    170. Muscle magnetic resonance imaging in congenital myopathies due to ryanodine receptor type 1 gene mutations. (PubMed id 21911697)1 Klein A....Muntoni F. (Arch. Neurol. 2011)
    171. RYR1 mutations are a common cause of congenital myopathies with central nuclei. (PubMed id 20839240)1 Wilmshurst J.M....Jungbluth H. (Ann. Neurol. 2010)
    172. [Molecular genetic analysis of the ryanodine receptor gene (RYR1) in Korean malignant hyperthermia families]. (PubMed id 21157159)1 Lee H....Kim D.S. (Korean J Lab Med 2010)
    173. Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. (PubMed id 20962236)1 Perry S.W....Gelbard H.A. (J. Neurosci. 2010)
    174. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. (PubMed id 20961976)2 Lanner J.T.... Hamilton S.L. (Cold Spring Harb. Perspect. Biol. 2010)
    175. Familial RYR 1 mutation associated with mild and severe central core disease. (PubMed id 20724266)1 Erendzhinova E....Lemire E.G. (Can J Neurol Sci 2010)
    176. Allele-specific differences in ryanodine receptor 1 mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia. (PubMed id 20482855)1 Grievink H. and Stowell K.M. (Orphanet J Rare Dis 2010)
    177. Mild clinical and histopathological features in patients who carry the frequent and causative malignant hyperthermia RyR1 mutation p.Thr2206Met. (PubMed id 19919814)1 Rueffert H....Schober R. (Clin. Neuropathol. 2009)
    178. Novel variants near the central domain of RYR1 in two malignant hyperthermia-susceptible families from Taiwan. (PubMed id 19762757)1 Chen P.L....Day Y.J. (Anesth. Analg. 2009)
    179. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    180. Identification of malignant hyperthermia-susceptible ryanodine receptor type 1 gene (RYR1) mutations in a child who died in a car after exposure to a high environmental temperature. (PubMed id 19223216)1 Nishio H....Suzuki K. (Leg Med (Tokyo) 2009)
    181. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. (PubMed id 19095005)1 Yamazaki D....Takeshima H. (amp 2009)
    182. Epigenetic allele silencing and variable penetrance of malignant hyperthermia susceptibility. (PubMed id 19454545)1 Robinson R.L....Shaw M.A. (Br J Anaesth 2009)
    183. HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. (PubMed id 19009018)1 Norman J.P....Gelbard H.A. (PLoS ONE 2008)
    184. A fulminant malignant hyperthermia episode in a patient with ryanodine receptor gene mutation p.Tyr522Ser. (PubMed id 19020143)1 Girard T....Hofer C.K. (Anesth. Analg. 2008)
    185. Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line. (PubMed id 19120137)1 Jurkovicova D....Krizanova O. (Ann. N. Y. Acad. Sci. 2008)
    186. Malignant hyperthermia susceptibility diagnosed with a family-specific ryanodine receptor gene type 1 mutation. (PubMed id 18306019)1 Tanabe T....Nishino I. (J Anesth 2008)
    187. Voltage-dependent Ca2+ channels, not ryanodine receptors, activate Ca2+-dependent BK potassium channels in human retinal pigment epithelial cells. (PubMed id 19096717)1 Wimmers S....Strauss O. (Mol. Vis. 2008)
    188. Novel ryanodine receptor mutation that may cause malignant hyperthermia. (PubMed id 18719443)1 Kaufmann A....Weigl L.G. (Anesthesiology 2008)
    189. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (Proteomics 2008)
    190. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. (PubMed id 18713863)1 Jurynec M.J....Grunwald D.J. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    191. Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release. (PubMed id 18092949)1 Jones P.P....Chen S.R. (Biochem. J. 2008)
    192. Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression. (PubMed id 18927079)1 Vukcevic M....Treves S. (J. Biol. Chem. 2008)
    193. King-denborough syndrome caused by a novel mutation in the ryanodine receptor gene. (PubMed id 18765655)1 D'Arcy C.E....Ryan M.M. (Neurology 2008)
    194. Remodeling of ryanodine receptor complex causes 'leaky' channels: a molecular mechanism for decreased exercise capacity. (PubMed id 18268335)2 Bellinger A.M....Marks A.R. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    195. Caffeine analogs: biomedical impact. (PubMed id 17514358)7 Daly J.W. (Cell. Mol. Life Sci. 2007)
    196. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    197. A truncation in the RYR1 gene associated with central core lesions in skeletal muscle fibres. (PubMed id 17293538)1 Rossi D....Sorrentino V. (J. Med. Genet. 2007)
    198. Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins. (PubMed id 16484216)1 Lee E.H....Allen P.D. (J. Biol. Chem. 2006)
    199. Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes. (PubMed id 15774471)1 Dammermann W. and Guse A.H. (J. Biol. Chem. 2005)
    200. Dantrolene--a review of its pharmacology, therapeutic use and new developments. (PubMed id 15023108)7 Krause T....Wappler F. (Anaesthesia 2004)
    201. Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model. (PubMed id 15210166)1 Wehner M....Olthoff D. (Neuromuscul. Disord. 2004)
    202. Mutation analysis of two patients with hypokalemic periodic paralysis and suspected malignant hyperthermia. (PubMed id 15221887)2 Marchant C.L.... Robinson R.L. (Muscle Nerve 2004)
    203. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    204. [Dantrolene. Pharmacological and therapeutic aspects]. (PubMed id 12666006)7 Gerbershagen M.U....Wappler F. (Anaesthesist 2003)
    205. FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. (PubMed id 12704193)1 Avila G....Dirksen R.T. (J. Biol. Chem. 2003)
    206. Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling. (PubMed id 12810060)1 Hwang S.Y....Koulen P. (Cell Calcium 2003)
    207. A homozygous splicing mutation causing a depletion of skeletal muscle RYR1 is associated with multi-minicore disease congenital myopathy with ophthalmoplegia. (PubMed id 12719381)2 Monnier N....Lunardi J. (Hum. Mol. Genet. 2003)
    208. Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. (PubMed id 14532276)1 Stange M....Meissner G. (J. Biol. Chem. 2003)
    209. Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma. (PubMed id 14596927)1 McCarthy T.V....Mackrill J.J. (FEBS Lett. 2003)
    210. TTD: Therapeutic Target Database. (PubMed id 11752352)7 Chen X....Chen Y.Z. (Nucleic Acids Res. 2002)
    211. Troponin I converts the skeletal muscle ryanodine receptor into a rectifying calcium release channel. (PubMed id 11943213)1 VarsA!nyi M....JA^na I. (FEBS Lett. 2002)
    212. Novel skeletal muscle ryanodine receptor mutation in a large Brazilian family with malignant hyperthermia. (PubMed id 12123492)2 McWilliams S....Sambuughin N. (Clin. Genet. 2002)
    213. RyR1 and RyR3 isoforms provide distinct intracellular Ca2+ signals in HEK 293 cells. (PubMed id 12045220)1 Rossi D....Sorrentino V. (J. Cell. Sci. 2002)
    214. RYR1 mutations causing central core disease are associated with more severe malignant hyperthermia in vitro contracture test phenotypes. (PubMed id 12124989)1 Robinson R.L....Hopkins P.M. (Hum. Mutat. 2002)
    215. Identification of a novel mutation in the ryanodine receptor gene (RYR1) in patients with malignant hyperthermia. (PubMed id 11241852)2 Rueffert H.... Froster U.G. (Hum. Mutat. 2001)
    216. Identification and functional characterization of a novel ryanodine receptor mutation causing malignant hyperthermia in North American and South American families. (PubMed id 11525881)2 Sambuughin N.... Goldfarb L.G. (Neuromuscul. Disord. 2001)
    217. Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1. (PubMed id 11069905)1 Kirchhefer U....Jones L.R. (J. Biol. Chem. 2001)
    218. B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators. (PubMed id 11673462)1 Girard T....Treves S. (J. Biol. Chem. 2001)
    219. Genotype-phenotype comparison of the Swiss malignant hyperthermia population. (PubMed id 11668625)1 Girard T....Treves S. (Hum. Mutat. 2001)
    220. Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor. (PubMed id 11171121)1 Bultynck G....Parys J.B. (Biochem. J. 2001)
    221. A novel ryanodine receptor gene mutation causing both cores and rods in congenital myopathy. (PubMed id 11113224)2 Scacheri P.C.... Subramony S.H. (Neurology 2000)
    222. An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor. (PubMed id 11063719)4 Monnier N....Lunardi J. (Hum. Mol. Genet. 2000)
    223. Malignant hyperthermia in infancy and identification of novel RYR1 mutation. (PubMed id 10823104)2 Chamley D.... Brown R.L. (Br. J. Anaesth. 2000)
    224. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    225. Location of ryanodine receptor binding site on skeletal muscle triadin. (PubMed id 9890886)1 Caswell A.H....Brandt N.R. (Biochemistry 1999)
    226. A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca(2+) release channel function and severe central core disease. (PubMed id 10097181)2 Lynch P.J.... McCarthy T.V. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    227. Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium. 1975. (PubMed id 9924249)7 Harrison G.G. (Br J Anaesth 1998)
    228. Malignant-hyperthermia susceptibility is associated with a mutation of the alpha-1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle. (PubMed id 9199552)1 Monnier N.... Lunardi J. (Am. J. Hum. Genet. 1997)
    229. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. (PubMed id 9298970)1 Treves S....Zorzato F. (Biochemistry 1997)
    230. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. (PubMed id 9287354)1 Zhang L....Jones L.R. (J. Biol. Chem. 1997)
    231. No association between the neuroleptic malignant syndrome and mutations in the RYR1 gene associated malignant hyperthermia. (PubMed id 8981316)4 Miyatake R....Suwaki H. (J. Neurol. Sci. 1996)
    232. Alterations of inositol polyphosphates in skeletal muscle during porcine malignant hyperthermia. (PubMed id 7488490)7 Tonner P.H....Schulte am Esch J. (Br J Anaesth 1995)
    233. Association of triadin with the ryanodine receptor and calsequestrin in the lumen of the sarcoplasmic reticulum. (PubMed id 7721813)1 Guo W. and Campbell K.P. (J. Biol. Chem. 1995)
    234. The point mutation Arg615--&gt;Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia. (PubMed id 7511586)1 Otsu K....Tada M. (J. Biol. Chem. 1994)
    235. Congenital Fiber-Type Disproportion (PubMed id 20301436)1 Pagon R.A....Stephens K. (1993)
    236. Central Core Disease (PubMed id 20301565)1 Pagon R.A....Stephens K. (1993)
    237. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. (PubMed id 8432525)1 Trask B....Carrano A. (Genomics 1993)
    238. Malignant Hyperthermia Susceptibility (PubMed id 20301325)1 Pagon R.A....Stephens K. (1993)
    239. Multiminicore Disease (PubMed id 20301467)1 Pagon R.A....Stephens K. (1993)
    240. Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase. (PubMed id 8380342)1 Suko J....Hellmann G. (Biochim. Biophys. Acta 1993)
    241. FK506 binding protein associated with the calcium release channel (ryanodine receptor). (PubMed id 1374404)1 Jayaraman T....Marks A.R. (J. Biol. Chem. 1992)
    242. Dantrolene--in vitro studies in malignant hyperthermia susceptible (MHS) and normal skeletal muscle. (PubMed id 6704779)7 Britt B.A....Endrenyi L. (Can Anaesth Soc J 1984)
    243. Dantrolene dose response in malignant hyperthermia-susceptible (MHS) swine: method to obtain prophylaxis and therapeusis. (PubMed id 7362049)7 Flewellen E.H. and Nelson T.E. (Anesthesiology 1980)
    244. Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum. (PubMed id 15677376)9 Murayama T....Ogawa Y. (Am. J. Physiol., Cell Physiol. 2005)
    245. Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. (PubMed id 12761215)9 Fessenden J.D....Allen P.D. (J. Biol. Chem. 2003)
    246. Functional expression of recombinant type 1 ryanodine receptor in insect cells. (PubMed id 11396983)9 AntaramiA!n A....Vaca L. (Cell Calcium 2001)
    247. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. (PubMed id 16120606)9 Hurne A.M....Pessah I.N. (J. Biol. Chem. 2005)
    248. Regulation of RYR1 activity by Ca(2+) and calmodulin. (PubMed id 10869186)9 Rodney G.G....Hamilton S.L. (Biochemistry 2000)
    249. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. (PubMed id 19509218)9 Barrientos G....Pessah I.N. (Mol. Pharmacol. 2009)
    250. Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies. (PubMed id 17483490)9 Zhou H....Muntoni F. (Brain 2007)
    251. Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol. (PubMed id 16737973)9 Fessenden J.D....Allen P.D. (J. Biol. Chem. 2006)
    252. Screening of the entire ryanodine receptor type 1 coding region for sequence variants associated with malignant hyperthermia susceptibility in the north american population. (PubMed id 15731587)9 Sambuughin N....Goldfarb L.G. (Anesthesiology 2005)
    253. Effects of pO2 on the activation of skeletal muscle ryanodine receptors by NO: a cautionary note. (PubMed id 16099502)9 Cheong E....Salama G. (Cell Calcium 2005)
    254. Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structure. (PubMed id 16260840)9 ZahradnA-k I....ZahradnA-kovA! A. (J. Gen. Physiol. 2005)
    255. Tectoridins modulate skeletal and cardiac muscle sarcoplasmic reticulum calcium-release channels. (PubMed id 10869412)9 Bidasee K.R....Besch H.R. (J. Pharmacol. Exp. Ther. 2000)
    256. RyR1 modulation by oxidation and calmodulin. (PubMed id 11232598)9 Hamilton S.L. and Reid M.B. (amp 2000)
    257. The cytoplasmic loops between domains II and III and domains III and IV in the skeletal muscle dihydropyridine receptor bind to a contiguous site in the skeletal muscle ryanodine receptor. (PubMed id 9792715)9 Leong P. and MacLennan D.H. (J. Biol. Chem. 1998)
    258. Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor. (PubMed id 8785329)9 Wagenknecht T....Fleischer S. (Biophys. J. 1996)
    259. Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. (PubMed id 20080402)9 Zhou H....Jungbluth H. (Neuromuscul. Disord. 2010)
    260. A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1). (PubMed id 19390614)9 Ramachandran S....Dokholyan N.V. (PLoS Comput. Biol. 2009)
    261. In vitro modulation of the cardiac ryanodine receptor activity by Homer1. (PubMed id 19296124)9 Pouliquin P....Dulhunty A.F. (Pflugers Arch. 2009)
    262. Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites. (PubMed id 17645636)9 Laver D.R. (amp 2007)
    263. Retina expresses a novel variant of the ryanodine receptor. (PubMed id 18005065)9 Shoshan-Barmatz V....Vardi N. (Eur. J. Neurosci. 2007)
    264. Structural determinants of 4-chloro-m-cresol required for activation of ryanodine receptor type 1. (PubMed id 16601083)9 Jacobson A.R....Fessenden J.D. (Mol. Pharmacol. 2006)
    265. Recognition and activation of ryanodine receptors by purines. (PubMed id 16529557)9 Butanda-Ochoa A....DA-az-MuA+oz M. (Curr. Med. Chem. 2006)
    266. Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling. (PubMed id 16357209)9 Cheng W....Coronado R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    267. Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels. (PubMed id 15998242)9 Aracena P....Hidalgo C. (amp 2005)
    268. Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle. (PubMed id 15548569)9 Perez C.F....Allen P.D. (Am. J. Physiol., Cell Physiol. 2005)
    269. Membrane topology and membrane retention of the ryanodine receptor calcium release channel. (PubMed id 15054223)9 Ma J....Bhat M.B. (Cell Biochem. Biophys. 2004)
    270. Different regions in skeletal and cardiac muscle ryanodine receptors are involved in transducing the functional effects of calmodulin. (PubMed id 15215235)9 Yamaguchi N....Meissner G. (J. Biol. Chem. 2004)
    271. Sarcolemma agonist-induced interactions between InsP3 and ryanodine receptors in Ca2+ oscillations and waves in smooth muscle. (PubMed id 14505449)9 McCarron J.G....Muir T.C. (Biochem. Soc. Trans. 2003)
    272. Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes. (PubMed id 12198090)9 O'Connell K.M....Dirksen R.T. (J. Gen. Physiol. 2002)
    273. Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling. (PubMed id 11964231)9 O'Brien J.J....Beam K.G. (Biophys. J. 2002)
    274. FKBP12 modulation of the binding of the skeletal ryanodine receptor onto the II-III loop of the dihydropyridine receptor. (PubMed id 11751303)9 O'Reilly F.M....Ronjat M. (Biophys. J. 2002)
    275. Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene encoding the skeletal muscle calcium release channel (RYR1). (PubMed id 11575546)9 Roberts M.C....Hogan K. (Anesthesiology 2001)
    276. Muscle autoantibodies in subgroups of myasthenia gravis patients. (PubMed id 10896269)9 Romi F....Gilhus N.E. (J. Neurol. 2000)
    277. Characterization of a calcium-regulation domain of the skeletal-muscle ryanodine receptor. (PubMed id 10998347)9 Hayek S.M....Ma J. (Biochem. J. 2000)
    278. Thymomas express epitopes shared by the ryanodine receptor. (PubMed id 7499495)9 Mygland A....Gilhus N.E. (J. Neuroimmunol. 1995)
    279. Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle. (PubMed id 19802526)9 Bannister R.A. and Beam K.G. (J. Muscle Res. Cell. Motil. 2009)
    280. Ryanodine receptor 1 mediates Ca2+ transport and influences the biomechanical properties in RBCs. (PubMed id 19767002)9 Wang X....Chien S. (J Biomech 2009)
    281. Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. (PubMed id 17869085)9 Hong M.Y....Heber D. (J. Nutr. Biochem. 2008)
    282. Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction coupling. (PubMed id 17846166)9 Goonasekera S.A....Dirksen R.T. (J. Gen. Physiol. 2007)
    283. A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity. (PubMed id 16227507)9 Xiong L....Hamilton S.L. (Biophys. J. 2006)
    284. Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure. (PubMed id 15967847)9 Oda T....Matsuzaki M. (Circulation 2005)
    285. [Genetic of diseases by abnormal functioning of the skeletal muscle-calcium releasing complex]. (PubMed id 15269663)9 Lunardi J. and Monnier N. (Rev. Neurol. (Paris) 2004)
    286. Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor). (PubMed id 12707260)9 Yamaguchi N....Meissner G. (J. Biol. Chem. 2003)
    287. RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. (PubMed id 12668474)9 Perez C.F....Allen P.D. (Biophys. J. 2003)
    288. Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol. (PubMed id 11990295)9 Treves S....Zorzato F. (Cell Calcium 2002)
    289. Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine. (PubMed id 11226332)9 Fessenden J.D....Pessah I.N. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    290. Ryanodine receptor isoforms in excitation-contraction coupling. (PubMed id 10463072)9 Ogawa Y....Murayama T. (Adv. Biophys. 1999)
    291. A 37-amino acid sequence in the skeletal muscle ryanodine receptor interacts with the cytoplasmic loop between domains II and III in the skeletal muscle dihydropyridine receptor. (PubMed id 9525869)9 Leong P. and MacLennan D.H. (J. Biol. Chem. 1998)
    292. Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels. (PubMed id 9593671)9 Nakai J....Beam K.G. (J. Biol. Chem. 1998)
    293. Ryanodine receptor gene expression thymomas. (PubMed id 9736058)9 Kusner L.L....Kaminski H.J. (amp 1998)
    294. Functional nonequality of the cardiac and skeletal ryanodine receptors. (PubMed id 9023375)9 Nakai J....Beam K.G. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    295. Modulation of cardiac ryanodine receptors by sorcin. (PubMed id 9312152)9 Lokuta A.J....Valdivia H.H. (J. Biol. Chem. 1997)
    296. Phosphorylation of dihydropyridine receptor II-III loop peptide regulates skeletal muscle calcium release channel function. Evidence for an essential role of the beta-OH group of Ser687. (PubMed id 7629172)9 Lu X....Meissner G. (J. Biol. Chem. 1995)
    297. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. (PubMed id 20307258)9 Fornuskova D....Zeman J. (Biochem. J. 2010)
    298. &quot;Pulling the plug&quot; on cellular copper: the role of mitochondria in copper export. (PubMed id 18522804)9 Leary S.C....Cobine P.A. (Biochim. Biophys. Acta 2009)
    299. Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling. (PubMed id 19131108)9 Kimura T....Dulhunty A.F. (Cell Calcium 2009)
    300. Homeostatic and stimulus-induced coupling of the L-type Ca2+ channel to the ryanodine receptor in the hippocampal neuron in slices. (PubMed id 19411104)9 Berrout J. and Isokawa M. (Cell Calcium 2009)
    301. Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. (PubMed id 19402748)9 SamsA^ M....Allen P.D. (PLoS Biol. 2009)
    302. A calcium-induced calcium release mechanism mediated by calsequestrin. (PubMed id 18538346)9 Lee Y.S. and Keener J.P. (J. Theor. Biol. 2008)
    303. Loss of the calmodulin-dependent inhibition of the RyR1 calcium release channel upon oxidation of methionines in calmodulin. (PubMed id 18076146)9 Boschek C.B....Bigelow D.J. (Biochemistry 2008)
    304. Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. (PubMed id 18534980)9 Samavati L....HA1ttemann M. (J. Biol. Chem. 2008)
    305. Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. (PubMed id 18171678)9 Xu L....Meissner G. (J. Biol. Chem. 2008)
    306. Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies. (PubMed id 16909197)9 Dulhunty A.F....Kimura T. (J. Muscle Res. Cell. Motil. 2006)
    307. Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide. (PubMed id 16387763)9 Gangopadhyay J.P. and Ikemoto N. (Biophys. J. 2006)
    308. Electron-conformational model of ryanodine receptor lattice dynamics. (PubMed id 16061275)9 Moskvin A.S....Markhasin V.S. (Prog. Biophys. Mol. Biol. 2006)
    309. Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A. (PubMed id 14535845)9 Lee C.W....Kim J.I. (Biochem. J. 2004)
    310. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. (PubMed id 15197184)9 Voss A.A....Pessah I.N. (J. Biol. Chem. 2004)
    311. A new mutation in the skeletal ryanodine receptor gene (RYR1) is potentially causative of malignant hyperthermia, central core disease, and severe skeletal malformation. (PubMed id 14708096)9 Rueffert H....Froster U.G. (Am. J. Med. Genet. A 2004)
    312. Ryanodine receptor signaling is required for anti-CD3-induced T cell proliferation, interleukin-2 synthesis, and interleukin-2 receptor signaling. (PubMed id 15108363)9 Conrad D.M....Hoskin D.W. (J. Cell. Biochem. 2004)
    313. Ryanodine receptor defects in muscle genetic diseases. (PubMed id 15336972)9 Brini M. (Biochem. Biophys. Res. Commun. 2004)
    314. Calmodulin oxidation and methionine to glutamine substitutions reveal methionine residues critical for functional interaction with ryanodine receptor-1. (PubMed id 12586832)9 Balog E.M....Fruen B.R. (J. Biol. Chem. 2003)
    315. Amino acids 1-1,680 of ryanodine receptor type 1 hold critical determinants of skeletal type for excitation-contraction coupling. Role of divergence domain D2. (PubMed id 12900411)9 Perez C.F....Allen P.D. (J. Biol. Chem. 2003)
    316. Regulation of calcium release by interdomain interaction within ryanodine receptors. (PubMed id 11861212)9 Ikemoto N. and Yamamoto T. (Front. Biosci. 2002)
    317. Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin. (PubMed id 12185083)9 Xiong L.W....Hamilton S.L. (J. Biol. Chem. 2002)
    318. Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3. (PubMed id 11867448)9 Nabhani T....GarcA-a J. (Biophys. J. 2002)
    319. Results of contracture tests with halothane, caffeine, and ryanodine depend on different malignant hyperthermia-associated ryanodine receptor gene mutations. (PubMed id 12151923)9 Fiege M....Schulte Am Esch J. (Anesthesiology 2002)
    320. Functional effects of central core disease mutations in the cytoplasmic region of the skeletal muscle ryanodine receptor. (PubMed id 11524458)9 Avila G. and Dirksen R.T. (J. Gen. Physiol. 2001)
    321. Functionally separate intracellular Ca2+ stores in smooth muscle. (PubMed id 11477079)9 Flynn E.R....McCarron J.G. (J. Biol. Chem. 2001)
    322. Activation of purified cardiac ryanodine receptors by dihydropyridine agonists. (PubMed id 11179064)9 Sagawa T....Wasserstrom J.A. (Am. J. Physiol. Heart Circ. Physiol. 2001)
    323. Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis. (PubMed id 11182151)9 Shelton G.D....Aarli J.A. (Vet. Immunol. Immunopathol. 2001)
    324. Autoantibodies in thymoma-associated myasthenia gravis with myositis or neuromyotonia. (PubMed id 10768628)9 Mygland A....Aarli J.A. (Arch. Neurol. 2000)
    325. Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding. (PubMed id 9886919)9 Zhang J.Z....Hamilton S.L. (Am. J. Physiol. 1999)
    326. Electron spin resonance investigation of the cyanyl and azidyl radical formation by cytochrome c oxidase. (PubMed id 10455126)9 Chen Y.R....Mason R.P. (J. Biol. Chem. 1999)
    327. A role for cysteine 3635 of RYR1 in redox modulation and calmodulin binding. (PubMed id 10601232)9 Porter Moore C....Hamilton S.L. (J. Biol. Chem. 1999)
    328. Subtype specificity of the ryanodine receptor for Ca2+ signal amplification in excitation-contraction coupling. (PubMed id 8947039)9 Yamazawa T....Iino M. (EMBO J. 1996)
    329. The action of carboxyl modifying reagents on the ryanodine receptor/Ca2+ release channel of skeletal muscle sarcoplasmic reticulum. (PubMed id 8839452)9 Feng W. and Shoshan-Barmatz V. (Mol. Membr. Biol. 1996)
    330. Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function? (PubMed id 8874493)9 Sutko J.L. and Airey J.A. (Physiol. Rev. 1996)
    331. A cosmid and yeast artificial chromosome contig containing the complete ryanodine receptor (RYR1) gene. (PubMed id 8406483)9 Rouquier S....de Jong P. (Genomics 1993)
    332. Evidence for genetic heterogeneity of malignant hyperthermia susceptibility. (PubMed id 1598899)9 Deufel T....Johnson K.J. (Am. J. Hum. Genet. 1992)
    333. The decrease of expression of ryanodine receptor sub-type 2 is reversed by gentamycin sulphate in vascular myocytes from mdx mice. (PubMed id 19298530)9 Morel J.L....Macrez N. (J. Cell. Mol. Med. 2009)
    334. The cardiac alpha(1C) subunit can support excitation-triggered Ca2+ entry in dysgenic and dyspedic myotubes. (PubMed id 19625771)9 Bannister R.A. and Beam K.G. (Channels (Austin) 2009)
    335. Loss of function of Sco1 and its interaction with cytochrome c oxidase. (PubMed id 19295170)9 Stiburek L....Zeman J. (Am. J. Physiol., Cell Physiol. 2009)
    336. Role of ryanodine receptor subtypes in initiation and formation of calcium sparks in arterial smooth muscle: comparison with striated muscle. (PubMed id 20029633)9 Essin K. and Gollasch M. (amp 2009)
    337. Mechanisms underlying angiotensin II-induced calcium oscillations. (PubMed id 18562632)9 Edwards A. and Pallone T.L. (Am. J. Physiol. Renal Physiol. 2008)
    338. FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle. (PubMed id 17950843)9 MacMillan D....McCarron J.G. (Cell Calcium 2008)
    339. Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase. (PubMed id 17430883)9 Khalimonchuk O....Winge D.R. (J. Biol. Chem. 2007)
    340. Characterization of recessive RYR1 mutations in core myopathies. (PubMed id 16940308)9 Zhou H....Treves S. (Hum. Mol. Genet. 2006)
    341. Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase. (PubMed id 17008312)9 Cobine P.A....Winge D.R. (J. Biol. Chem. 2006)
    342. Effects of peptide C corresponding to the Glu724-Pro760 region of the II-III loop of the DHP (dihydropyridine) receptor alpha1 subunit on the domain- switch-mediated activation of RyR1 (ryanodine receptor 1) Ca2+ channels. (PubMed id 16302848)9 Bannister M.L. and Ikemoto N. (Biochem. J. 2006)
    343. A new approach for studying fast biological reactions involving nitric oxide: generation of NO using photolabile ruthenium and manganese NO donors. (PubMed id 17421079)9 Szundi I....EinarsdA^ttir O. (Photochem. Photobiol. 2006)
    344. Copper trafficking to the mitochondrion and assembly of copper metalloenzymes. (PubMed id 16631971)9 Cobine P.A....Winge D.R. (Biochim. Biophys. Acta 2006)
    345. The ryanodine receptors Ca2+ release channels: cellular redox sensors? (PubMed id 16036616)9 Hidalgo C....Carrasco M.A. (IUBMB Life 2005)
    346. Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6. (PubMed id 16049346)9 Zissimopoulos S. and Lai F.A. (Cell Biochem. Biophys. 2005)
    347. Expression of FKBP12 and ryanodine receptors (RyRs) in the spinal cord of MND patients. (PubMed id 16036432)9 Kihira T....Kondo T. (Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2005)
    348. Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals. (PubMed id 16157373)9 Kubota M....Kuba K. (Cell Calcium 2005)
    349. A calmodulin binding domain of RyR increases activation of spontaneous Ca2+ sparks in frog skeletal muscle. (PubMed id 15640144)9 Rodney G.G....Schneider M.F. (J. Biol. Chem. 2005)
    350. Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. (PubMed id 14600284)9 Gafni J....Pessah I.N. (Toxicol. Sci. 2004)
    351. The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain. (PubMed id 14706290)9 Zhu X....Valdivia H.H. (Cell Calcium 2004)
    352. Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition. (PubMed id 15564379)9 Jordan T....DiMario J.X. (J. Cell. Sci. 2004)
    353. Retrograde activation of store-operated calcium channel. (PubMed id 12765683)9 Ma J. and Pan Z. (Cell Calcium 2003)
    354. Ryanodine receptor type 3: why another ryanodine receptor isoform? (PubMed id 12456308)9 Sorrentino V. (Front. Biosci. 2003)
    355. Cyclic ADP-ribose increases Ca2+ removal in smooth muscle. (PubMed id 12966165)9 Bradley K.N....McCarron J.G. (J. Cell. Sci. 2003)
    356. Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells. (PubMed id 12393358)9 Girard T....Urwyler A. (Br J Anaesth 2002)
    357. Coupling of RYR1 and L-type calcium channels via calmodulin binding domains. (PubMed id 11500484)9 Sencer S....Hamilton S.L. (J. Biol. Chem. 2001)
    358. Reversible thiol-dependent activation of ryanodine-sensitive Ca2+ release channel by etoposide (VP-16) phenoxyl radical. (PubMed id 11232603)9 Fabisiak J.P....Kagan V.E. (amp 2000)
    359. A postulated role of the near amino-terminal domain of the ryanodine receptor in the regulation of the sarcoplasmic reticulum Ca(2+) channel. (PubMed id 10559212)9 El-Hayek R....Ikemoto N. (J. Biol. Chem. 1999)
    360. Effect of sphingosylphosphorylcholine on the single channel gating properties of the cardiac ryanodine receptor. (PubMed id 10556518)9 Uehara A....Berlin J.R. (FEBS Lett. 1999)
    361. Apocalmodulin and Ca2+ calmodulin bind to the same region on the skeletal muscle Ca2+ release channel. (PubMed id 10387100)9 Moore C.P....Hamilton S.L. (Biochemistry 1999)
    362. The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor. (PubMed id 10419512)9 Grabner M....Beam K.G. (J. Biol. Chem. 1999)
    363. Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. (PubMed id 9512016)9 Jafri M.S....Winslow R.L. (Biophys. J. 1998)
    364. Numerical analysis of ryanodine receptor activation by L-type channel activity in the cardiac muscle diad. (PubMed id 9199776)9 Cannell M.B. and Soeller C. (Biophys. J. 1997)
    365. [Structure and expression of the porcine skeletal muscle ryanodine receptor gene]. (PubMed id 9035969)9 Brenig B....Krempler A. (DTW. Dtsch. Tierarztl. Wochenschr. 1996)
    366. Affinity purification of the ryanodine receptor/calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12. (PubMed id 7669046)9 Xin H.B....Fleischer S. (Biochem. Biophys. Res. Commun. 1995)
    367. Cross-linking of the ryanodine receptor/Ca2+ release channel from skeletal muscle. (PubMed id 7632708)9 Shoshan-Barmatz V....Ostersetzer O. (Biochim. Biophys. Acta 1995)
    368. Application of bacterial artificial chromosomes to the generation of contiguous physical maps: a pilot study of human ryanodine receptor gene (RYR1) region. (PubMed id 8203748)9 Rouquier S....Giorgi D. (Anal. Biochem. 1994)
    369. Ryanodine receptor antibodies related to severity of thymoma associated myasthenia gravis. (PubMed id 8021674)9 Mygland A....Gilhus N.E. (J. Neurol. Neurosurg. Psychiatr. 1994)
    370. A brain-specific transcript from the 3'-terminal region of the skeletal muscle ryanodine receptor gene. (PubMed id 8097730)9 Takeshima H....Sugimoto T. (FEBS Lett. 1993)
    371. (PubMed id 17194179)9 
    372. Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. (PubMed id 20144583)9 Aguirre E....Cadenas S. (Biochim. Biophys. Acta 2010)
    373. Degenerative diseases, oxidative stress and cytochrome c oxidase function. (PubMed id 19303362)9 Kadenbach B....Vogt S. (Trends Mol Med 2009)
    374. Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation. (PubMed id 20007376)9 Collman J.P....DecrAcau R.A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    375. Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2. (PubMed id 19168034)9 Liu D....Board P.G. (Biochem. Pharmacol. 2009)
    376. CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy. (PubMed id 19356589)9 Meng X....Yin C.C. (J. Mol. Biol. 2009)
    377. Endoplasmic reticulum Ca(2+) release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity. (PubMed id 19747726)9 Ruiz A....Alberdi E. (Cell Calcium 2009)
    378. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. (PubMed id 19541638)9 Dammermann W....Potter B.V. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    379. A double mutation of the ryanodine receptor type 1 gene in a malignant hyperthermia family with multiminicore myopathy. (PubMed id 19513315)9 Jeong S.K....Kim D.S. (J Clin Neurol 2008)
    380. Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscle. (PubMed id 18353852)9 Tazzeo T....Janssen L.J. (Eur. Respir. J. 2008)
    381. Distinct mechanisms for dysfunctions of mutated ryanodine receptor isoforms. (PubMed id 18067858)9 Ogawa Y. (Biochem. Biophys. Res. Commun. 2008)
    382. Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm. (PubMed id 18313359)9 Treves S....Zorzato F. (Curr Opin Pharmacol 2008)
    383. Interaction of the Lys(3614)-Asn(3643) calmodulin-binding domain with the Cys(4114)-Asn(4142) region of the type 1 ryanodine receptor is involved in the mechanism of Ca2+/agonist-induced channel activation. (PubMed id 18171325)9 Gangopadhyay J.P. and Ikemoto N. (Biochem. J. 2008)
    384. The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor. (PubMed id 18556650)9 Bannister R.A....Beam K.G. (J. Biol. Chem. 2008)
    385. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. (PubMed id 18174159)9 Dror V....Johnson J.D. (J. Biol. Chem. 2008)
    386. Ryanodine receptors as pharmacological targets for heart disease. (PubMed id 17588328)9 Santonastasi M. and Wehrens X.H. (Acta Pharmacol. Sin. 2007)
    387. Human Sco1 functional studies and pathological implications of the P174L mutant. (PubMed id 17182746)9 Banci L....Wang S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    388. Functional effects of mutations identified in patients with multiminicore disease. (PubMed id 17365175)9 Zorzato F....Treves S. (IUBMB Life 2007)
    389. Voltage-gated Ca2+ entry and ryanodine receptor Ca2+-induced Ca2+ release in preglomerular arterioles. (PubMed id 17190906)9 Fellner S.K. and Arendshorst W.J. (Am. J. Physiol. Renal Physiol. 2007)
    390. Storage of an excess proton in the hydrogen-bonded network of the d-pathway of cytochrome C oxidase: identification of a protonated water cluster. (PubMed id 17309257)9 Xu J....Voth G.A. (J. Am. Chem. Soc. 2007)
    391. Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. (PubMed id 17412417)9 Weisleder N....Ma J. (Cell Calcium 2007)
    392. Central core disease. (PubMed id 17504518)9 Jungbluth H. (Orphanet J Rare Dis 2007)
    393. The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site. (PubMed id 17879109)9 Laver D.R....Ikemoto N. (J. Membr. Biol. 2007)
    394. Multi-minicore Disease. (PubMed id 17631035)9 Jungbluth H. (Orphanet J Rare Dis 2007)
    395. Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide. (PubMed id 17164295)9 Palacios-Callender M....Moncada S. (J. Cell. Sci. 2007)
    396. Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). (PubMed id 17023049)9 Ta T.A. and Pessah I.N. (Neurotoxicology 2007)
    397. Enhancement of Ca2+-induced Ca2+ release by cyclic ADP-ribose in frog motor nerve terminals. (PubMed id 17320303)9 Hachisuka J....Kuba K. (Neuroscience 2007)
    398. RyR isoforms and fibre type-specific expression of proteins controlling intracellular calcium concentration in skeletal muscles. (PubMed id 16874451)9 Reggiani C. and te Kronnie T. (J. Muscle Res. Cell. Motil. 2006)
    399. Characterization of ryanodine receptor-mediated calcium release in human B cells: relevance to diagnostic testing for malignant hyperthermia. (PubMed id 16732090)9 McKinney L.C....Klein M.G. (Anesthesiology 2006)
    400. Flubendiamide, a novel Ca2+ channel modulator, reveals evidence for functional cooperation between Ca2+ pumps and Ca2+ release. (PubMed id 16481391)9 Masaki T....Hirooka T. (Mol. Pharmacol. 2006)
    401. Occurrence of atypical Ca2+ transients in triadin-binding deficient-RYR1 mutants. (PubMed id 17092484)9 Lee E.H....Kim d.o. .H. (Biochem. Biophys. Res. Commun. 2006)
    402. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). (PubMed id 16411661)9 Pessah I.N....Wong P.W. (Chem. Res. Toxicol. 2006)
    403. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors. (PubMed id 16249374)9 Ta T.A....Pessah I.N. (Mol. Pharmacol. 2006)
    404. Malignant hyperthermia in Japan: mutation screening of the entire ryanodine receptor type 1 gene coding region by direct sequencing. (PubMed id 16732084)9 Ibarra M C.A....Nishino I. (Anesthesiology 2006)
    405. Structural characterization of the RyR1-FKBP12 interaction. (PubMed id 16405911)9 SamsA^ M....Allen P.D. (J. Mol. Biol. 2006)
    406. Transmembrane proton translocation by cytochrome c oxidase. (PubMed id 16824482)9 BrAondAcn G....Brzezinski P. (Biochim. Biophys. Acta 2006)
    407. Different types of biological proton transfer reactions studied by quantum chemical methods. (PubMed id 16483535)9 Blomberg M.R. and Siegbahn P.E. (Biochim. Biophys. Acta 2006)
    408. Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels. (PubMed id 16075044)9 Priori S.G. and Napolitano C. (J. Clin. Invest. 2005)
    409. Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells. (PubMed id 15733545)9 Luo D....Han Q. (Eur. J. Pharmacol. 2005)
    410. Probing the role of negatively charged amino acid residues in ion permeation of skeletal muscle ryanodine receptor. (PubMed id 15863483)9 Wang Y....Meissner G. (Biophys. J. 2005)
    411. Two-dimensional crystallization of the ryanodine receptor Ca2+ release channel on lipid membranes. (PubMed id 15681238)9 Yin C.C....Lai F.A. (J. Struct. Biol. 2005)
    412. Intracellular Ca2+ dynamics in malignant hyperthermia and central core disease: established concepts, new cellular mechanisms involved. (PubMed id 15589992)9 Avila G. (Cell Calcium 2005)
    413. Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. (PubMed id 15656791)9 Paul-Pletzer K....Parness J. (Biochem. J. 2005)
    414. Homer modulates NFAT-dependent signaling during muscle differentiation. (PubMed id 16226241)9 Stiber J.A....Rosenberg P. (Dev. Biol. 2005)
    415. Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. (PubMed id 15047862)9 George C.H....Lai F.A. (Mol. Biol. Cell 2004)
    416. Evidence for conformational coupling between two calcium channels. (PubMed id 15310845)9 Paolini C....Franzini-Armstrong C. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    417. Ryanodine receptors in peritoneal mast cells: possible role in the modulation of exocytotic activity. (PubMed id 14634821)9 Jaffe E.H....Caputo C. (Pflugers Arch. 2004)
    418. Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system. (PubMed id 15650244)9 De Flora A....Bruzzone S. (Ann. N. Y. Acad. Sci. 2004)
    419. Mapping sites of potential proximity between the dihydropyridine receptor and RyR1 in muscle using a cyan fluorescent protein-yellow fluorescent protein tandem as a fluorescence resonance energy transfer probe. (PubMed id 15280389)9 Papadopoulos S....Beam K.G. (J. Biol. Chem. 2004)
    420. Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells. (PubMed id 15709700)9 Carrasco M.A....Hidalgo C. (Biol. Res. 2004)
    421. Calsequestrin and the calcium release channel of skeletal and cardiac muscle. (PubMed id 15050380)9 Beard N.A....Dulhunty A.F. (Prog. Biophys. Mol. Biol. 2004)
    422. The relative position of RyR feet and DHPR tetrads in skeletal muscle. (PubMed id 15313613)9 Paolini C....Franzini-Armstrong C. (J. Mol. Biol. 2004)
    423. Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease. (PubMed id 15336973)9 Lyfenko A.D....Dirksen R.T. (Biochem. Biophys. Res. Commun. 2004)
    424. FPL-64176 alters both charge movement and Ca2+ release properties in amphibian muscle fibres. (PubMed id 15061146)9 Chawla S. and Huang C.L. (Pflugers Arch. 2004)
    425. Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory module. (PubMed id 13679303)9 Lee E.H....Allen P.D. (Am. J. Physiol., Cell Physiol. 2004)
    426. The interaction of ryanoids with individual ryanodine receptor channels. (PubMed id 15709679)9 Williams A.J. and Tanna B. (Biol. Res. 2004)
    427. Protocol for the sequence analysis of ryanodine receptor subtype 1 gene transcripts from human leukocytes. (PubMed id 12883401)9 Kraev N....MacLennan D.H. (Anesthesiology 2003)
    428. Kinetics of cardiac RyR channel gating studied at high temporal resolution. (PubMed id 14535832)9 Dura M....ZahradnA-kovA! A. (Physiol Res 2003)
    429. Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. (PubMed id 12754204)9 George C.H....Lai F.A. (J. Biol. Chem. 2003)
    430. Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine. (PubMed id 12632186)9 Yasukochi M....Berlin J.R. (Pflugers Arch. 2003)
    431. [Expression and role of inositol 1,4,5-trisphosphate receptor and ryanodine receptor in a human lens epithelial cell line]. (PubMed id 12921667)9 Qu B. and Zhang J.S. (Zhonghua Yan Ke Za Zhi 2003)
    432. PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. (PubMed id 12629052)9 Reiken S....Marks A.R. (J. Cell Biol. 2003)
    433. Regulation of dynamic behavior of cardiac ryanodine receptor by Mg2+ under simulated physiological conditions. (PubMed id 12839831)9 ZahradnA-kovA! A....GyAPrke S. (Am. J. Physiol., Cell Physiol. 2003)
    434. The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease. (PubMed id 12642598)9 Avila G....Dirksen R.T. (J. Gen. Physiol. 2003)
    435. Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1. (PubMed id 12364321)9 Papineni R.V....Hamilton S.L. (J. Biol. Chem. 2002)
    436. Role of the sarcoplasmic reticulum in uterine smooth muscle. (PubMed id 12164316)9 Wray S....Shmigol T. (Novartis Found. Symp. 2002)
    437. Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism. (PubMed id 12477390)9 Thomas J.M....Galione A. (Curr. Biol. 2002)
    438. Decreased gene expression of calretinin and ryanodine receptor type 1 in tottering mice. (PubMed id 12372549)9 Cicale M....de Bartolomeis A. (Brain Res. Bull. 2002)
    439. The spectrum of pathology in central core disease. (PubMed id 12467748)9 Sewry C.A....Quinlivan R.C. (Neuromuscul. Disord. 2002)
    440. T-tubule depolarization-induced local events in the ryanodine receptor, as monitored with the fluorescent conformational probe incorporated by mediation of peptide A. (PubMed id 11682466)9 Yamamoto T. and Ikemoto N. (J. Biol. Chem. 2002)
    441. Agonist-induced phasic and tonic responses in smooth muscle are mediated by InsP(3). (PubMed id 11973361)9 McCarron J.G....Muir T.C. (J. Cell. Sci. 2002)
    442. Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor. (PubMed id 12102654)9 Hohenegger M....Zidar A. (Biochem. J. 2002)
    443. Functional importance and caffeine sensitivity of ryanodine receptors in primary lymphocytes. (PubMed id 11360934)9 Ritter M....Barry W.H. (Int. Immunopharmacol. 2001)
    444. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). (PubMed id 11159936)9 Tiso N.... Rampazzo A. (Hum. Mol. Genet. 2001)
    445. Short- and long-term functional alterations of the skeletal muscle calcium release channel (Ryanodine receptor) by Suramin: apparent dissociation of single channel current recording and [3H]ryanodine binding. (PubMed id 11179450)9 Suko J....Drobny H. (Mol. Pharmacol. 2001)
    446. Malignant hyperthermia and excitation-contraction coupling. (PubMed id 11412150)9 Melzer W. and Dietze B. (Acta Physiol. Scand. 2001)
    447. Ryanodine receptor mutations in malignant hyperthermia and central core disease. (PubMed id 10790202)9 McCarthy T.V....Lynch P.J. (Hum. Mutat. 2000)
    448. Three-dimensional structure of ryanodine receptor isoform three in two conformational states as visualized by cryo-electron microscopy. (PubMed id 10734096)9 Sharma M.R....Wagenknecht T. (J. Biol. Chem. 2000)
    449. Low N-ethylmaleimide concentrations activate ryanodine receptors by a reversible interaction, not an alkylation of critical thiols. (PubMed id 10998412)9 Menshikova E.V....Salama G. (J. Biol. Chem. 2000)
    450. Expression of ryanodine receptor RyR3 produces Ca2+ sparks in dyspedic myotubes. (PubMed id 10811728)9 Ward C.W....Allen P.D. (J. Physiol. (Lond.) 2000)
    451. Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. (PubMed id 10903993)9 Katoh H....Bers D.M. (Circ. Res. 2000)
    452. Mutation of divergent region 1 alters caffeine and Ca(2+) sensitivity of the skeletal muscle Ca(2+) release channel (ryanodine receptor). (PubMed id 10766801)9 Du G.G....MacLennan D.H. (J. Biol. Chem. 2000)
    453. Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms. (PubMed id 10856121)9 Bultynck G....De Smedt H. (J. Physiol. (Lond.) 2000)
    454. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. (PubMed id 10764737)9 Chan S.L....Mattson M.P. (J. Biol. Chem. 2000)
    455. The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. (PubMed id 10966111)9 Eu J.P....Meissner G. (Cell 2000)
    456. Evidence for a role of the lumenal M3-M4 loop in skeletal muscle Ca(2+) release channel (ryanodine receptor) activity and conductance. (PubMed id 10920015)9 Gao L....Meissner G. (Biophys. J. 2000)
    457. The CD38-cyclic ADP-ribose signaling system in insulin secretion. (PubMed id 10331647)9 Okamoto H. (Mol. Cell. Biochem. 1999)
    458. Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor. (PubMed id 10336416)9 Xin H.B....Fleischer S. (J. Biol. Chem. 1999)
    459. [3H]Azidodantrolene: synthesis and use in identification of a putative skeletal muscle dantrolene binding site in sarcoplasmic reticulum. (PubMed id 10354395)9 Palnitkar S.S....Parness J. (J. Med. Chem. 1999)
    460. Isoform-specific interactions between halothane and the ryanodine receptor Ca(2+)-release channel: implications for malignant hyperthermia and the protein theory of anaesthetic action. (PubMed id 10643591)9 FrAPmming G.R. and Ohlendieck K. (Naturwissenschaften 1999)
    461. Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. (PubMed id 9743407)9 Brooksbank R.L....Savage N. (Anesthesiology 1998)
    462. Reactivity of nitric oxide with cytochrome c oxidase: interactions with the binuclear centre and mechanism of inhibition. (PubMed id 9623807)9 Torres J....Wilson M.T. (J. Bioenerg. Biomembr. 1998)
    463. The influence of perchlorate ions on complex charging transients in amphibian striated muscle. (PubMed id 9503332)9 Huang C.L. (J. Physiol. (Lond.) 1998)
    464. Possible regulation of the skeletal muscle ryanodine receptor by a polyubiquitin binding subunit of the 26S proteasome. (PubMed id 9571168)9 Mackrill J.J. (Biochem. Biophys. Res. Commun. 1998)
    465. Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. (PubMed id 9405457)9 Wagenknecht T....Fleischer S. (J. Biol. Chem. 1997)
    466. Nitric oxide activates skeletal and cardiac ryanodine receptors. (PubMed id 9056074)9 Stoyanovsky D....Salama G. (Cell Calcium 1997)
    467. Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. (PubMed id 9013543)9 Noguchi N....Okamoto H. (J. Biol. Chem. 1997)
    468. Niflumic acid differentially modulates two types of skeletal ryanodine-sensitive Ca(2+)-release channels. (PubMed id 9374644)9 Oba T. (Am. J. Physiol. 1997)
    469. Chloride-dependent sarcoplasmic reticulum Ca2+ release correlates with increased Ca2+ activation of ryanodine receptors. (PubMed id 8913591)9 Fruen B.R....Louis C.F. (Biophys. J. 1996)
    470. Functionally heterogenous ryanodine receptors in avian cerebellum. (PubMed id 8663321)9 Sierralta J....SuA!rez-Isla B.A. (J. Biol. Chem. 1996)
    471. A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1). (PubMed id 8978780)9 Wolz W....MA1ller C.R. (Cytogenet. Cell Genet. 1996)
    472. Ryanodine action at calcium release channels. 1. importance of hydroxyl substituents. (PubMed id 8691427)9 Jefferies P.R....Casida J.E. (J. Med. Chem. 1996)
    473. Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects. (PubMed id 8618963)9 Mickelson J.R. and Louis C.F. (Physiol. Rev. 1996)
    474. Modulation of the skeletal muscle ryanodine receptor by endogenous phosphorylation of 160/150-kDa proteins of the sarcoplasmic reticulum. (PubMed id 8765098)9 Orr I. and Shoshan-Barmatz V. (Biochim. Biophys. Acta 1996)
    475. [What significance to genotype changes have in diagnosis of malignant hyperthermia?]. (PubMed id 8962927)9 Steinfath M....Wappler F. (Anasthesiol Intensivmed Notfallmed Schmerzther 1996)
    476. Three-dimensional architecture of the skeletal muscle ryanodine receptor. (PubMed id 7641882)9 Wagenknecht T. and Radermacher M. (FEBS Lett. 1995)
    477. Ryanodine-induced calcium release from hepatic microsomes and permeabilized hepatocytes. (PubMed id 7611401)9 Lilly L.B. and Gollan J.L. (Am. J. Physiol. 1995)
    478. Dihydropyridine receptor-ryanodine receptor interactions in skeletal muscle excitation-contraction coupling. (PubMed id 8825041)9 Meissner G. and Lu X. (Biosci. Rep. 1995)
    479. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PubMed id 7592869)9 Lam E.... Wiederrecht G.J. (J. Biol. Chem. 1995)
    480. Highly cooperative and hysteretic response of the skeletal muscle ryanodine receptor to changes in proton concentrations. (PubMed id 7948677)9 Ma J. and Zhao J. (Biophys. J. 1994)
    481. Involvement of the brain type of ryanodine receptor in T-cell proliferation. (PubMed id 7523185)9 Hakamata Y.... Imoto K. (FEBS Lett. 1994)
    482. Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia. (PubMed id 8053891)9 Treves S....Zorzato F. (Biochem. J. 1994)
    483. Peroxide-induced spectral perturbations of the 280-nm absorption band of cytochrome c oxidase. (PubMed id 7926003)9 Larsen R.W. (FEBS Lett. 1994)
    484. Structural determinants of high-affinity binding of ryanoids to the vertebrate skeletal muscle ryanodine receptor: a comparative molecular field analysis. (PubMed id 8193121)9 Welch W....Sutko J.L. (Biochemistry 1994)
    485. IgG subclass distribution of ryanodine receptor autoantibodies in patients with myasthenia gravis and thymoma. (PubMed id 8216692)9 Mygland A....Gilhus N.E. (J. Autoimmun. 1993)
    486. A cysteine-for-arginine substitution (R614C) in the human skeletal muscle calcium release channel cosegregates with malignant hyperthermia. (PubMed id 1510267)9 Hogan K....Gregg R.G. (Anesth. Analg. 1992)
    487. A simple, fast, one-step method for the purification of the skeletal-muscle ryanodine receptor. (PubMed id 1637323)9 Shoshan-Barmatz V. and Zarka A. (Biochem. J. 1992)
    488. Reactive oxygen species modify the structure and function of the cardiac sarcoplasmic reticulum calcium-release channel. (PubMed id 1653624)9 Holmberg S.R....Williams A.J. (Cardioscience 1991)
    489. Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling. (PubMed id 19910470)9 Kovacs E....Liliom K. (J. Biol. Chem. 2010)
    490. CGRP, a vasodilator neuropeptide that stimulates neuromuscular transmission and EC coupling. (PubMed id 19485922)9 Vega A.V. and Avila G. (Curr Vasc Pharmacol 2010)
    491. Role of calcium signalling and phosphorylations in disruption of the epithelial junctions by Pseudomonas aeruginosa quorum sensing molecule. (PubMed id 20434232)9 VikstrAPm E....Magnusson K.E. (Eur. J. Cell Biol. 2010)
    492. Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes. (PubMed id 19934645)9 Harzheim D....Roderick H.L. (Channels (Austin) 2010)
    493. Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications. (PubMed id 20162100)9 BolaA+os J.P. and Heales S.J. (Front Neuroenergetics 2010)
    494. RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. (PubMed id 20207743)9 Eltit J.M....Lopez J.R. (J. Biol. Chem. 2010)
    495. Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. (PubMed id 19713530)9 Taylor C.T. and Moncada S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    496. A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks. (PubMed id 19716384)9 Baker K.D....Rickard N.S. (Behav. Brain Res. 2010)
    497. Ryanodine receptor calcium channels and their partners as drug targets. (PubMed id 20097179)9 Mackrill J.J. (Biochem. Pharmacol. 2010)
    498. Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. (PubMed id 19364981)9 GA^mez A.M....Benitah J.P. (Circulation 2009)
    499. Regulation by FK506 and rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR. (PubMed id 19785652)9 MacMillan D. and McCarron J.G. (Br. J. Pharmacol. 2009)
    500. Catalytic reduction of O2 by cytochrome C using a synthetic model of cytochrome C oxidase. (PubMed id 19317484)9 Collman J.P....Yang Y. (J. Am. Chem. Soc. 2009)
    501. The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways. (PubMed id 19126405)9 Bose D.D. and Thomas D.W. (Biochem. Biophys. Res. Commun. 2009)
    502. Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle. (PubMed id 19376574)9 Wei L....Dulhunty A.F. (Cell Calcium 2009)
    503. Effects of inserting fluorescent proteins into the alpha1S II-III loop: insights into excitation-contraction coupling. (PubMed id 19564426)9 Bannister R.A....Beam K.G. (J. Gen. Physiol. 2009)
    504. Effects of extracellular calcium concentration on the glutamate release by bioactive glass (BG60S) preincubated osteoblasts. (PubMed id 19636109)9 Valerio P....Leite M.F. (Biomed Mater 2009)
    505. [Effects of modulators of calcium metabolism on mesenteric artery contractions during activation of P2X receptors in guinea-pig]. (PubMed id 19827633)9 Sukhanova K.h.I.u....Hordiienko D.V. (Fiziol Zh 2009)
    506. Luminal Ca(2+) activation of cardiac ryanodine receptors by luminal and cytoplasmic domains. (PubMed id 19255753)9 Laver D.R. (Eur. Biophys. J. 2009)
    507. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. (PubMed id 18954145)9 Pessah I.N....Feng W. (Chem. Res. Toxicol. 2009)
    508. Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells. (PubMed id 19554099)9 Henderson K....Eckhert C.D. (PLoS ONE 2009)
    509. First genomic rearrangement of the RYR1 gene associated with an atypical presentation of lethal neonatal hypotonia. (PubMed id 19734047)9 Monnier N....Lunardi J. (Neuromuscul. Disord. 2009)
    510. 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist. (PubMed id 19492987)9 Kirchberger T....Guse A.H. (Biochem. J. 2009)
    511. Commonly used ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps. (PubMed id 19904006)9 Al-Mousa F. and Michelangeli F. (Pharmacol Rep 2009)
    512. Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen. (PubMed id 19278523)9 Beard N.A....Dulhunty A.F. (amp 2009)
    513. The role of CACNA1S in predisposition to malignant hyperthermia. (PubMed id 19825159)9 Carpenter D....Shaw M.A. (BMC Med. Genet. 2009)
    514. From the ryanodine receptor to cardiac arrhythmias. (PubMed id 19667488)9 Eisner D.A....Trafford A.W. (Circ. J. 2009)
    515. Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy. (PubMed id 19437551)9 Acsadi G....HA1ttemann M. (J. Neurosci. Res. 2009)
    516. Polysaccharide storage myopathy phenotype in quarter horse-related breeds is modified by the presence of an RYR1 mutation. (PubMed id 19056269)9 McCue M.E....Mickelson J.R. (Neuromuscul. Disord. 2009)
    517. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. (PubMed id 19458227)9 Patel J.C....Rice M.E. (J. Neurosci. 2009)
    518. Role of ryanodine receptor as a CaA^(+) regulatory center in normal and failing hearts. (PubMed id 19167631)9 Yano M....Matsuzaki M. (J Cardiol 2009)
    519. Water may inhibit oxygen binding in hemoprotein models. (PubMed id 19246375)9 Collman J.P....Yang Y. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    520. [Molecular architecture of the sarcoplasmic reticulum and its role in the ECC]. (PubMed id 19233437)9 Rigoard P....Lapierre F. (Neurochirurgie 2009)
    521. Isolation of regulatory-competent, phosphorylated cytochrome C oxidase. (PubMed id 19426869)9 Lee I....HA1ttemann M. (Meth. Enzymol. 2009)
    522. Effects of small molecule modulators on ATP binding to skeletal ryanodine receptor. (PubMed id 19636685)9 Dias J.M. and Vogel P.D. (Protein J. 2009)
    523. A computational analysis of localized Ca2+-dynamics generated by heterogeneous release sites. (PubMed id 19440797)9 Cooper Z....Mazzag B. (Bull. Math. Biol. 2009)
    524. Electron ionization mass spectrometry of the ryanodine receptor-based Ca(2+)-channel stabilizer S-107 and its implementation into routine doping control. (PubMed id 19575395)9 Thevis M....SchAonzer W. (Rapid Commun. Mass Spectrom. 2009)
    525. Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. (PubMed id 18620751)9 Wang Y....Meissner G. (Cell Calcium 2009)
    526. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. (PubMed id 19337518)9 Yang D....Lein P.J. (Environ. Health Perspect. 2009)
    527. Ca(2+) channels on the move. (PubMed id 19928968)9 Taylor C.W....Rahman T. (Biochemistry 2009)
    528. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. (PubMed id 19033399)9 Luciani D.S....Johnson J.D. (Diabetes 2009)
    529. Role of coupled gating between cardiac ryanodine receptors in the genesis of triggered arrhythmias. (PubMed id 19429830)9 Chen W....Shiferaw Y. (Am. J. Physiol. Heart Circ. Physiol. 2009)
    530. Biochemical and genetic analysis of 3-methylglutaconic aciduria type IV: a diagnostic strategy. (PubMed id 19015156)9 Wortmann S.B....Morava E. (Brain 2009)
    531. Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin. (PubMed id 19398037)9 Wei L....Beard N.A. (amp 2009)
    532. Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor. (PubMed id 19076161)9 Tae H.S....Casarotto M.G. (amp 2009)
    533. Ca2+ dysregulation in Ryr1(I4895T/wt) mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods. (PubMed id 19959667)9 Zvaritch E....MacLennan D.H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    534. cADPR stimulates SERCA activity in Xenopus oocytes. (PubMed id 19131109)9 Yamasaki-Mann M....Parker I. (Cell Calcium 2009)
    535. What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? (PubMed id 19150449)9 Eisner D.A....Trafford A.W. (J. Mol. Cell. Cardiol. 2009)
    536. Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation &quot;hot spot&quot; loop. (PubMed id 19541610)9 Amador F.J....Ikura M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    537. Kinetic gating of the proton pump in cytochrome c oxidase. (PubMed id 19666617)9 Kim Y.C....Hummer G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    538. The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. (PubMed id 19114636)9 Bannister R.A....Beam K.G. (J. Gen. Physiol. 2009)
    539. Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. (PubMed id 19053230)9 Sun J....Meissner G. (Biochemistry 2008)
    540. Ryanodine receptor as a new therapeutic target of heart failure and lethal arrhythmia. (PubMed id 18362417)9 Yano M. (Circ. J. 2008)
    541. Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase. (PubMed id 18956030)9 Collman J.P. and DecrAcau R.A. (Chem. Commun. (Camb.) 2008)
    542. Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. (PubMed id 18406528)9 Nagarkatti N....DeLorenzo R.J. (Neurosci. Lett. 2008)
    543. Nuclear Ca2+ regulates cardiomyocyte function. (PubMed id 18201761)9 Guatimosim S....Leite M.F. (Cell Calcium 2008)
    544. Autoantibodies against TRPC3 and ryanodine receptor in myasthenia gravis. (PubMed id 18602703)9 Takamori M. (J. Neuroimmunol. 2008)
    545. Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells. (PubMed id 18434746)9 Zheng Y.M....Wang Y.X. (J. Vasc. Res. 2008)
    546. Inhibition of mGluR1 and IP3Rs impairs long-term memory formation in young chicks. (PubMed id 18495503)9 Baker K.D....Rickard N.S. (Neurobiol Learn Mem 2008)
    547. Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels. (PubMed id 18192376)9 Bannister R.A....Beam K.G. (Biophys. J. 2008)
    548. Structural and functional characterization of ryanodine receptor-natrin toxin interaction. (PubMed id 18658224)9 Zhou Q....Liu Z. (Biophys. J. 2008)
    549. Molecular mechanism of proton translocation by cytochrome c oxidase. (PubMed id 17949262)9 Belevich I. and Verkhovsky M.I. (amp 2008)
    550. Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. (PubMed id 18518861)9 Kong H....Chen S.R. (Biochem. J. 2008)
    551. The sarcoplasmic reticulum and arrhythmogenic calcium release. (PubMed id 18006483)9 Venetucci L.A....Eisner D.A. (Cardiovasc. Res. 2008)
    552. The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction. (PubMed id 18440065)9 Hayrapetyan V....Koulen P. (Cell Calcium 2008)
    553. Animal models for genetic neuromuscular diseases. (PubMed id 18202836)9 Vainzof M....Yamamoto L.U. (J. Mol. Neurosci. 2008)
    554. Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation. (PubMed id 17574671)9 Curtis T.M....McGeown J.G. (Cell Calcium 2008)
    555. Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling. (PubMed id 18006436)9 Bito V....Sipido K.R. (Cardiovasc. Res. 2008)
    556. O2 reduction to H2O by the multicopper oxidases. (PubMed id 18648693)9 Solomon E.I....Yoon J. (Dalton Trans 2008)
    557. Heme-heme communication during the alkaline-induced structural transition in cytochrome c oxidase. (PubMed id 18187199)9 Ji H....Yeh S.R. (J. Inorg. Biochem. 2008)
    558. A single luminally continuous sarcoplasmic reticulum with apparently separate Ca2+ stores in smooth muscle. (PubMed id 18096697)9 McCarron J.G. and Olson M.L. (J. Biol. Chem. 2008)
    559. Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. (PubMed id 18316371)9 Dadsetan S....Fomina A.F. (J. Biol. Chem. 2008)
    560. Model studies of azide binding to functional analogues of CcO. (PubMed id 18361486)9 Collman J.P....Yang Y. (Inorg Chem 2008)
    561. Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase. (PubMed id 18070608)9 Khalimonchuk O. and Winge D.R. (Biochim. Biophys. Acta 2008)
    562. Paraneoplastic myasthenia gravis: immunological and clinical aspects. (PubMed id 18717725)9 Skeie G.O. and Romi F. (Eur. J. Neurol. 2008)
    563. Electronic wiring of a multi-redox site membrane protein in a biomimetic surface architecture. (PubMed id 18222995)9 Friedrich M.G....Naumann R.L. (Biophys. J. 2008)
    564. Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase. (PubMed id 18430799)9 Kaila V.R....WikstrAPm M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    565. Ryanodine receptor expression correlates with tumor grade in breast cancer. (PubMed id 18431693)9 Abdul M....Hoosein N. (Pathol. Oncol. Res. 2008)
    566. Interaction of nitric oxide with a functional model of cytochrome c oxidase. (PubMed id 18632561)9 Collman J.P....Eberspacher T.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    567. Identification of ryanodine receptor 1 single-nucleotide polymorphisms by high-resolution melting using the LightCycler 480 System. (PubMed id 18082125)9 Grievink H. and Stowell K.M. (Anal. Biochem. 2008)
    568. Overexpression of P-glycoprotein in L1210/VCR cells is associated with changes in several endoplasmic reticulum proteins that may be partially responsible for the lack of thapsigargin sensitivity. (PubMed id 18981537)9 Seres M....SulovA! Z. (Gen. Physiol. Biophys. 2008)
    569. A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites. (PubMed id 18038129)9 Laver D.R....Ikemoto N. (Eur. Biophys. J. 2008)
    570. Caffeine-inducible ATP release is mediated by Ca2+-signal transducing system from the endoplasmic reticulum to mitochondria. (PubMed id 18446524)9 Katsuragi T....Migita K. (Naunyn Schmiedebergs Arch. Pharmacol. 2008)
    571. Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart. (PubMed id 17509680)9 Dibb K.M....Trafford A.W. (Cell Calcium 2007)
    572. Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle. (PubMed id 17661063)9 Ikezoe K....Kira J. (Acta Neuropathol. 2007)
    573. Is excitation-contraction coupling impaired in myasthenia gravis? (PubMed id 17307394)9 Nakata M....Hattori T. (Clin Neurophysiol 2007)
    574. Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. (PubMed id 17237236)9 Phimister A.J....Pessah I.N. (J. Biol. Chem. 2007)
    575. NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. (PubMed id 16790499)9 Soares S....Chini E.N. (Am. J. Physiol., Cell Physiol. 2007)
    576. Myasthenia gravis patients with ryanodine receptor antibodies have distinctive clinical features. (PubMed id 17539937)9 Romi F....Gilhus N.E. (Eur. J. Neurol. 2007)
    577. Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. (PubMed id 17448375)9 Mochizuki M....Matsuzaki M. (J. Am. Coll. Cardiol. 2007)
    578. Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells. (PubMed id 17640951)9 Ostrovskaya O....Wilson S.M. (J. Pharmacol. Exp. Ther. 2007)
    579. Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. (PubMed id 17361990)9 Hamada T....Ikemoto N. (Biochemistry 2007)
    580. Na/Ca exchange: regulator of intracellular calcium and source of arrhythmias in the heart. (PubMed id 17446473)9 Venetucci L.A....Eisner D.A. (Ann. N. Y. Acad. Sci. 2007)
    581. Role of the calcium store in uterine contractility. (PubMed id 17601757)9 Wray S. and Shmygol A. (amp 2007)
    582. Regulation of calcium signalling by adenine-based second messengers. (PubMed id 17233614)9 Fliegert R....Guse A.H. (Biochem. Soc. Trans. 2007)
    583. Exploring pathways and barriers for coupled ET/PT in cytochrome c oxidase: a general framework for examining energetics and mechanistic alternatives. (PubMed id 17350588)9 Olsson M.H....Warshel A. (Biochim. Biophys. Acta 2007)
    584. Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity. (PubMed id 17526017)9 Klegeris A....McGeer P.L. (J. Neurosci. Res. 2007)
    585. Accessibility of targeted DHPR sites to streptavidin and functional effects of binding on EC coupling. (PubMed id 17893191)9 Lorenzon N.M. and Beam K.G. (J. Gen. Physiol. 2007)
    586. Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element. (PubMed id 17937768)9 HA1ttemann M....Grossman L.I. (FEBS J. 2007)
    587. [Determination and clinical significance of serum anti-ryanodine receptor antibody in patients with myasthenia gravis]. (PubMed id 17536276)9 Cui L.Y....Zhang J.B. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007)
    588. Diseases associated with altered ryanodine receptor activity. (PubMed id 18193641)9 Durham W.J....Hamilton S.L. (Subcell. Biochem. 2007)
    589. Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor. (PubMed id 17606610)9 Meng X....Liu Z. (J. Biol. Chem. 2007)
    590. Calcium signaling phenomena in heart diseases: a perspective. (PubMed id 17119849)9 Chakraborti S....Chakraborti T. (Mol. Cell. Biochem. 2007)
    591. Age-dependent effects on functional aspects in human satellite cells. (PubMed id 17460197)9 Beccafico S....Fulle S. (Ann. N. Y. Acad. Sci. 2007)
    592. Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes. (PubMed id 18077344)9 Gonzalez D.R....Hare J.M. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    593. An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. (PubMed id 18003898)9 Zvaritch E....Maclennan D.H. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    594. Modification of cytosolic calcium signaling by subplasmalemmal microdomains. (PubMed id 17311908)9 Edwards A. and Pallone T.L. (Am. J. Physiol. Renal Physiol. 2007)
    595. Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents? (PubMed id 17055586)9 Dulhunty A.F....Casarotto M.G. (amp 2007)
    596. Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. (PubMed id 17956253)9 Chelu M.G. and Wehrens X.H. (Biochem. Soc. Trans. 2007)
    597. Theoretical study on electronic structures of FeOO, FeOOH, FeO(H2O), and FeO in hemes: as intermediate models of dioxygen reduction in cytochrome c oxidase. (PubMed id 17662458)9 Yoshioka Y....Mitani M. (J. Inorg. Biochem. 2007)
    598. SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects. (PubMed id 17515962)9 Vittorini S....Clerico A. (Mol. Med. 2007)
    599. Similarities and contrasts in ryanodine receptor localization and function in osteoclasts and striated muscle cells. (PubMed id 18083933)9 Huang C.L....Zaidi M. (Ann. N. Y. Acad. Sci. 2007)
    600. Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells. (PubMed id 17157326)9 Li X.H. and Wu Y.J. (Life Sci. 2007)
    601. Development of calcium releasing activity induced by inositol trisphosphate and cyclic ADP-ribose during in vitro maturation of sea urchin oocytes. (PubMed id 17118015)9 Miyata K....Kuroda H. (amp 2006)
    602. Redox regulation of the ryanodine receptor/calcium release channel. (PubMed id 17052227)9 Zissimopoulos S. and Lai F.A. (Biochem. Soc. Trans. 2006)
    603. Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP-ribose. (PubMed id 16796808)9 Zhang A.Y. and Li P.L. (J. Cell. Mol. Med. 2006)
    604. [Thymus CT scan and thymoma associated antibodies in myasthenia gravis with thymoma]. (PubMed id 16995304)9 Li Y.F....Cui L.Y. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006)
    605. Redox regulation of cardiac calcium channels and transporters. (PubMed id 16581043)9 Zima A.V. and Blatter L.A. (Cardiovasc. Res. 2006)
    606. Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-tubule structure in human heart failure. (PubMed id 16897575)9 Cannell M.B....Soeller C. (J. Muscle Res. Cell. Motil. 2006)
    607. Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle. (PubMed id 16227345)9 Yi X.Y....Li P.L. (Am. J. Physiol. Heart Circ. Physiol. 2006)
    608. Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells. (PubMed id 17086495)9 Ventura A.C. and Sneyd J. (Bull. Math. Biol. 2006)
    609. Ryanodine receptor regulates endogenous cannabinoid mobilization in the hippocampus. (PubMed id 16467427)9 Isokawa M. and Alger B.E. (J. Neurophysiol. 2006)
    610. Nervous control of ciliary beating by Cl(-), Ca(2+) and calmodulin in Tritonia diomedea. (PubMed id 16809467)9 Woodward O.M. and Willows A.O. (J. Exp. Biol. 2006)
    611. Calcium-transporters in myocardial cells. (PubMed id 17051729)9 Subramani S. and Subbanna P.K. (Indian J. Physiol. Pharmacol. 2006)
    612. Improved density functional theory/electrostatic calculation of the His291 protonation state in cytochrome C oxidase: self-consistent charges for solvation energy calculation. (PubMed id 16800531)9 Makhov D.V....Stuchebrukhov A.A. (J Phys Chem B 2006)
    613. Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidase. (PubMed id 17023543)9 Busenlehner L.S....Armstrong R.N. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    614. Organization of calcium channel beta1a subunits in triad junctions in skeletal muscle. (PubMed id 16317008)9 Leuranguer V....Beam K.G. (J. Biol. Chem. 2006)
    615. Controlled uncoupling and recoupling of proton pumping in cytochrome c oxidase. (PubMed id 16407159)9 BrAondAcn G....Brzezinski P. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    616. Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. (PubMed id 17172444)9 Sheridan D.C....Perez C.F. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    617. Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose. (PubMed id 16751979)9 Thompson M....Chini E.N. (Braz. J. Med. Biol. Res. 2006)
    618. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. (PubMed id 17074764)9 Gerasimenko J.V....Gerasimenko O.V. (J. Biol. Chem. 2006)
    619. Titin and ryanodine receptor antibodies in myasthenia gravis. (PubMed id 16637922)9 Skeie G.O....Gilhus N.E. (Acta Neurol. Scand., Suppl.c 2006)
    620. Mutations in RYR1 in malignant hyperthermia and central core disease. (PubMed id 16917943)9 Robinson R....Hopkins P. (Hum. Mutat. 2006)
    621. Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice. (PubMed id 17050533)9 Supnet C....Mayne M. (J. Biol. Chem. 2006)
    622. Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor. (PubMed id 17042924)9 Casarotto M.G....Dulhunty A.F. (amp 2006)
    623. Role of ryanodine receptor mutations in cardiac pathology: more questions than answers? (PubMed id 17052226)9 Thomas N.L....Lai F.A. (Biochem. Soc. Trans. 2006)
    624. Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals. (PubMed id 16855084)9 De Crescenzo V....Walsh J.V. (J. Neurosci. 2006)
    625. Intracellular calcium release and cardiac disease. (PubMed id 15709953)9 Wehrens X.H....Marks A.R. (Annu. Rev. Physiol. 2005)
    626. Effects of azumolene on Ca2+ sparks in skeletal muscle fibers. (PubMed id 15831441)9 Zhang Y....Schneider M.F. (J. Pharmacol. Exp. Ther. 2005)
    627. The timing of proton migration in membrane-reconstituted cytochrome c oxidase. (PubMed id 16306266)9 Salomonsson L....Brzezinski P. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    628. The origin of tubular aggregates in human myopathies. (PubMed id 16178054)9 Chevessier F....VerdiA"re-SahuquAc M. (J. Pathol. 2005)
    629. Abnormal ryanodine receptor function in heart failure. (PubMed id 15951021)9 Yano M....Matsuzaki M. (amp 2005)
    630. Clinical and histopathological aspects of central core disease associated and non-associated with RYR1 locus. (PubMed id 16550918)9 Romero N.B....Fardeau M. (Acta Myol 2005)
    631. Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores. (PubMed id 15910885)9 Zhuang S.Y....Deadwyler S.A. (Neuropharmacology 2005)
    632. Ryanodine receptor binding to FKBP12 is modulated by channel activation state. (PubMed id 16176935)9 Jones J.L....Blayney L.M. (J. Cell. Sci. 2005)
    633. Role of some unconserved residues in the &quot;C&quot; region of the skeletal DHPR II-III loop. (PubMed id 15769632)9 Dulhunty A.F....Casarotto M.G. (Front. Biosci. 2005)
    634. The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity. (PubMed id 15511220)9 Dulhunty A.F....Casarotto M.G. (Biochem. J. 2005)
    635. Activation of ryanodine receptors induces calcium influx in a neuroblastoma cell line lacking calcium influx factor activity. (PubMed id 15482258)9 Bose D.D....Thomas D.W. (Biochem. J. 2005)
    636. Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis. (PubMed id 15978749)9 Biswas G....Avadhani N.G. (Gene 2005)
    637. [Effect of carvedilol on ryanodine receptor in heart failure]. (PubMed id 16191273)9 Li R....Liu X.Y. (Zhonghua Er Ke Za Zhi 2005)
    638. Involvement of phospholipid, biomembrane integrity, and NO peroxidase activity in the NO catabolism by cytochrome c oxidase. (PubMed id 15963451)9 Chen Y.R....Zweier J.L. (Arch. Biochem. Biophys. 2005)
    639. Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. (PubMed id 16169970)9 Shannon T.R....Bers D.M. (Biophys. J. 2005)
    640. The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase. (PubMed id 16060655)9 BrAondAcn G....Brzezinski P. (Biochemistry 2005)
    641. Sulfur ligation in copper enzymes and models. (PubMed id 16051368)9 Belle C....Pierre J.L. (J. Inorg. Biochem. 2005)
    642. Disruption of endoplasmic reticulum calcium stores is involved in neuronal death induced by glycolysis inhibition in cultured hippocampal neurons. (PubMed id 16175570)9 HernA!ndez-Fonseca K. and Massieu L. (J. Neurosci. Res. 2005)
    643. Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells. (PubMed id 15795312)9 Zheng Y.M....Wang Y.X. (J. Gen. Physiol. 2005)
    644. Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. (PubMed id 16274254)9 Yamaguchi N....Meissner G. (Biochemistry 2005)
    645. The role of complement in myasthenia gravis: serological evidence of complement consumption in vivo. (PubMed id 15589053)9 Romi F....Gilhus N.E. (J. Neuroimmunol. 2005)
    646. Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition. (PubMed id 15530142)9 Haarmann C.S....Laver D.R. (Biochem. J. 2005)
    647. Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. (PubMed id 16168959)9 Hauser C.J....Itagaki K. (Biochem. Biophys. Res. Commun. 2005)
    648. Coupled calcium release channels and their regulation by luminal and cytosolic ions. (PubMed id 15915341)9 Laver D.R. (Eur. Biophys. J. 2005)
    649. Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels: perspectives from recombinant expression systems. (PubMed id 15858232)9 George C.H....Lai F.A. (Cell Biochem. Biophys. 2005)
    650. The ryanodine receptor mediates early zymogen activation in pancreatitis. (PubMed id 16186498)9 Husain S.Z....Gorelick F.S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    651. Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function. (PubMed id 15955561)9 Avila G. and Dirksen R.T. (Cell Calcium 2005)
    652. (De)constructing the ryanodine receptor: modeling ion permeation and selectivity of the calcium release channel. (PubMed id 16852978)9 Gillespie D....Meissner G. (J Phys Chem B 2005)
    653. Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach. (PubMed id 16126827)9 Wang K....Levine H. (Biophys. J. 2005)
    654. Acidity of a Cu-bound histidine in the binuclear center of cytochrome C oxidase. (PubMed id 16853946)9 Fadda E....PomA"s R. (J Phys Chem B 2005)
    655. Determination of the site of action of calcitonin gene-related peptide in the alteration of intracellular calcium levels in adult and neonatal rodent myocytes. (PubMed id 15979760)9 Bick R.J....Schiess M.C. (Peptides 2005)
    656. Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery. (PubMed id 16286507)9 Di Biase V. and Franzini-Armstrong C. (J. Cell Biol. 2005)
    657. Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells. (PubMed id 15054112)9 Kunerth S....Guse A.H. (J. Cell. Sci. 2004)
    658. Luminal Ca2+-regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters. (PubMed id 15545399)9 Laver D.R....Lamb G.D. (J. Gen. Physiol. 2004)
    659. Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion. (PubMed id 14592949)9 Yamamori E....Nakashima N. (Endocrinology 2004)
    660. Physiological and pathological modulation of ryanodine receptor function in cardiac muscle. (PubMed id 15110148)9 Eisner D.A....Trafford A.W. (Cell Calcium 2004)
    661. [Thymectomy and muscle antibodies in myasthenia gravis]. (PubMed id 15004605)9 Romi F....Aarli J.A. (Tidsskr. Nor. Laegeforen. 2004)
    662. Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle. (PubMed id 12959958)9 Glover L....Ohlendieck K. (J. Appl. Physiol. 2004)
    663. L-type Ca2+ channel and ryanodine receptor cross-talk in frog skeletal muscle. (PubMed id 14660705)9 Squecco R....Francini F. (J. Physiol. (Lond.) 2004)
    664. Denaturing HPLC-based approach for detecting RYR2 mutations involved in malignant arrhythmias. (PubMed id 15131021)9 Bagattin A....Danieli G.A. (Clin. Chem. 2004)
    665. Organization of Ca2+ release units in excitable smooth muscle of the guinea-pig urinary bladder. (PubMed id 15345562)9 Moore E.D....Franzini-Armstrong C. (Biophys. J. 2004)
    666. Structural requirements of the dihydropyridine receptor alpha1S II-III loop for skeletal-type excitation-contraction coupling. (PubMed id 14627713)9 Kugler G....Grabner M. (J. Biol. Chem. 2004)
    667. Functional equivalence of dihydropyridine receptor alpha1S and beta1a subunits in triggering excitation-contraction coupling in skeletal muscle. (PubMed id 15709683)9 Coronado R....Bhattacharya D. (Biol. Res. 2004)
    668. Inhibition of aroclor 1254-induced depletion of stored calcium prevents the cell death in catecholaminergic cells. (PubMed id 15212806)9 Kang J.H....Kim D.S. (Toxicology 2004)
    669. Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis. (PubMed id 15159506)9 Takamori M....Otsuka K. (Neurology 2004)
    670. Macromolecular complexes regulating cardiac ryanodine receptor function. (PubMed id 15276012)9 Bers D.M. (J. Mol. Cell. Cardiol. 2004)
    671. Multi-minicore disease revisited. (PubMed id 15608948)9 Nucci A....Martins Filho J. (Arq Neuropsiquiatr 2004)
    672. Appending a tris-imidazole ligand with a Tyr 244 mimic on the distal face of bromoacetamidoporphyrin. (PubMed id 15012093)9 Collman J.P....Costanzo S. (Org. Lett. 2004)
    673. Differential regulation of calcium homeostasis in adenocarcinoma cell line A549 and its Taxol-resistant subclone. (PubMed id 15066902)9 Padar S....Rahimian R. (Br. J. Pharmacol. 2004)
    674. Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor/calcium release channel. (PubMed id 15081811)9 Liu Z....Wagenknecht T. (J. Mol. Biol. 2004)
    675. The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. (PubMed id 15041652)9 GyAPrke I....GyAPrke S. (Biophys. J. 2004)
    676. Structural insights into excitation-contraction coupling by electron cryomicroscopy. (PubMed id 15627376)9 Serysheva I.I. (Biochemistry Mosc. 2004)
    677. Activating the ryanodine receptor with dihydropyridine receptor II-III loop segments: size and charge do matter. (PubMed id 15353321)9 Casarotto M.G....Dulhunty A.F. (Front. Biosci. 2004)
    678. Yeast contain a non-proteinaceous pool of copper in the mitochondrial matrix. (PubMed id 14729672)9 Cobine P.A....Winge D.R. (J. Biol. Chem. 2004)
    679. Multiminicore myopathy, central core disease, malignant hyperthermia susceptibility, and RYR1 mutations: one disease with many faces? (PubMed id 14732615)9 Mathews K.D. and Moore S.A. (Arch. Neurol. 2004)
    680. The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating. (PubMed id 14593104)9 Wang R....Chen S.R. (J. Biol. Chem. 2004)
    681. Involvement of a heptad repeat in the carboxyl terminus of the dihydropyridine receptor beta1a subunit in the mechanism of excitation-contraction coupling in skeletal muscle. (PubMed id 15298900)9 Sheridan D.C....Coronado R. (Biophys. J. 2004)
    682. Functional implications of RyR-dHPR relationships in skeletal and cardiac muscles. (PubMed id 15709676)9 Franzini-Armstrong C. (Biol. Res. 2004)
    683. Protein methylation activates reconstituted ryanodine receptor-ca release channels from coronary artery myocytes. (PubMed id 15118362)9 Chen Y.F....Li P.L. (J. Vasc. Res. 2004)
    684. Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling. (PubMed id 15201141)9 Weiss R.G....Dirksen R.T. (Am. J. Physiol., Cell Physiol. 2004)
    685. The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. (PubMed id 15464060)9 Squires P.E....Morgan N.G. (Eur. J. Pharmacol. 2004)
    686. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. (PubMed id 15505226)9 Cherednichenko G....Pessah I.N. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    687. Ryanodine receptor channelopathies. (PubMed id 15336975)9 Benkusky N.A....Valdivia H.H. (Biochem. Biophys. Res. Commun. 2004)
    688. Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. (PubMed id 15160398)9 Ferreiro E....Pereira C. (J. Neurosci. Res. 2004)
    689. Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). (PubMed id 12538591)9 Mitchell K.J....Rutter G.A. (J. Biol. Chem. 2003)
    690. Nitric oxide and excitation-contraction coupling. (PubMed id 12818561)9 Hare J.M. (J. Mol. Cell. Cardiol. 2003)
    691. Regulation of the RYR1 and RYR2 Ca2+ release channel isoforms by Ca2+-insensitive mutants of calmodulin. (PubMed id 12614169)9 Fruen B.R....Balog E.M. (Biochemistry 2003)
    692. The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors. (PubMed id 12620094)9 Haarmann C.S....Dulhunty A.F. (Biochem. J. 2003)
    693. Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. (PubMed id 12576471)9 Zhang J....Chen S.R. (J. Biol. Chem. 2003)
    694. Effects of eicosapentaenoic acid on cardiac SR Ca(2+)-release and ryanodine receptor function. (PubMed id 14613863)9 Swan J.S....Sitsapesan R. (Cardiovasc. Res. 2003)
    695. Calcium and cardiac arrhythmias: DADs, EADs, and alternans. (PubMed id 12892319)9 Clusin W.T. (Crit Rev Clin Lab Sci 2003)
    696. Pathogenesis of myositis and myasthenia associated with titin and ryanodine receptor antibodies. (PubMed id 14592894)9 Skeie G.O....Gilhus N.E. (Ann. N. Y. Acad. Sci. 2003)
    697. Disease severity and outcome in thymoma myasthenia gravis: a long-term observation study. (PubMed id 14641516)9 Romi F....Aarli J.A. (Eur. J. Neurol. 2003)
    698. Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions. (PubMed id 12975450)9 Kettlun C....Fill M. (J. Gen. Physiol. 2003)
    699. A locus on chromosome 15q for a dominantly inherited nemaline myopathy with core-like lesions. (PubMed id 12805120)9 Gommans I.M....Kremer H. (Brain 2003)
    700. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. (PubMed id 12919952)9 George C.H....Lai F.A. (Circ. Res. 2003)
    701. Immunophilins and coupled gating of ryanodine receptors. (PubMed id 12871170)9 Lehnart S.E....Marks A.R. (Curr Top Med Chem 2003)
    702. Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. (PubMed id 12860382)9 Zima A.V....Blatter L.A. (FEBS Lett. 2003)
    703. Ryanodine receptor antibodies in myasthenia gravis: epitope mapping and effect on calcium release in vitro. (PubMed id 12508299)9 Skeie G.O....Zorzato F. (amp 2003)
    704. Assembly of cytochrome c oxidase within the mitochondrion. (PubMed id 12755640)9 Carr H.S. and Winge D.R. (Acc. Chem. Res. 2003)
    705. Location of ryanodine and dihydropyridine receptors in frog myocardium. (PubMed id 12547789)9 Tijskens P....Franzini-Armstrong C. (Biophys. J. 2003)
    706. Structural characteristics that govern binding to, and modulation through, the cardiac ryanodine receptor nucleotide binding site. (PubMed id 12488550)9 Chan W.M....Sitsapesan R. (Mol. Pharmacol. 2003)
    707. Anaesthetic management of coronary artery bypass grafting in a patient with central core disease and susceptibility to malignant hyperthermia on statin therapy. (PubMed id 14570802)9 Johi R.R....Hopkins P.M. (Br J Anaesth 2003)
    708. [Congenital myopathies]. (PubMed id 14593641)9 Cabello A. and Ricoy-Campo J.R. (Rev Neurol 2003)
    709. [Modulation of extracellular calcium on miniature inhibitory postsynaptic currents of Xenopus' optic tectal neurons]. (PubMed id 14566411)9 Wang H. and Cai H.R. (Sheng Li Xue Bao 2003)
    710. Smooth muscle tissues express a major dominant negative splice variant of the type 3 Ca2+ release channel (ryanodine receptor). (PubMed id 12471029)9 Jiang D....Chen S.R. (J. Biol. Chem. 2003)
    711. Calcineurin and intracellular Ca2+-release channels: regulation or association? (PubMed id 14623304)9 Bultynck G....Parys J.B. (Biochem. Biophys. Res. Commun. 2003)
    712. Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS. (PubMed id 12609870)9 O'Neill E.R....Laver D.R. (Biophys. J. 2003)
    713. Modulation of the skeletal muscle Ca2+ release channel/ryanodine receptor by adenosine and its metabolites: a structure-activity approach. (PubMed id 12788371)9 Butanda-Ochoa A....DA-az-MuA+oz M. (amp 2003)
    714. Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex. (PubMed id 12354756)9 Schwarzmann N.... Guse A.H. (J. Biol. Chem. 2002)
    715. Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. (PubMed id 12456487)9 Jiang M.T....Valdivia H.H. (Circ. Res. 2002)
    716. Subconductance activity induced by quinidine and quinidinium in purified cardiac sarcoplasmic reticulum calcium release channels. (PubMed id 11961079)9 Tsushima R.G....Wasserstrom J.A. (J. Pharmacol. Exp. Ther. 2002)
    717. Sarcoplasmic reticulum function and contractile consequences in ureteric smooth muscles. (PubMed id 12164310)9 Burdyga T. and Wray S. (Novartis Found. Symp. 2002)
    718. Molecular genetics of ryanodine receptors Ca2+-release channels. (PubMed id 12543091)9 Rossi D. and Sorrentino V. (Cell Calcium 2002)
    719. Characterization of Ca(2+) signaling pathways in human mesenchymal stem cells. (PubMed id 12379176)9 Kawano S....Hiraoka M. (Cell Calcium 2002)
    720. Proton transport via the membrane surface. (PubMed id 12023208)9 Georgievskii Y....Stuchebrukhov A.A. (Biophys. J. 2002)
    721. Distal metal effects in cobalt porphyrins related to CcO. (PubMed id 12470053)9 Collman J.P....Solomon E.I. (Inorg Chem 2002)
    722. The role of calmodulin for inositol 1,4,5-trisphosphate receptor function. (PubMed id 12445455)9 Nadif Kasri N....De Smedt H. (Biochim. Biophys. Acta 2002)
    723. Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels? (PubMed id 12161072)9 Dirksen R.T. and Avila G. (Trends Cardiovasc. Med. 2002)
    724. Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position. (PubMed id 11818557)9 Felder E. and Franzini-Armstrong C. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    725. Spectroscopic monitoring of local conformational changes during the intramolecular domain-domain interaction of the ryanodine receptor. (PubMed id 11814342)9 Yamamoto T. and Ikemoto N. (Biochemistry 2002)
    726. Influence of structure, pH and membrane potential on proton movement in cytochrome oxidase. (PubMed id 12206898)9 Mills D.A. and Ferguson-Miller S. (Biochim. Biophys. Acta 2002)
    727. Effects of Mg(2+) and SR luminal Ca(2+) on caffeine-induced Ca(2+) release in skeletal muscle from humans susceptible to malignant hyperthermia. (PubMed id 12356882)9 Duke A.M....Steele D.S. (J. Physiol. (Lond.) 2002)
    728. Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor. (PubMed id 11274444)9 Avila G....Dirksen R.T. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    729. The carboxy-terminal calcium binding sites of calmodulin control calmodulin's switch from an activator to an inhibitor of RYR1. (PubMed id 11591164)9 Rodney G.G....Hamilton S.L. (Biochemistry 2001)
    730. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. (PubMed id 11035031)9 Dulhunty A....Board P. (J. Biol. Chem. 2001)
    731. Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells. (PubMed id 11695987)9 Kiselyov K....Muallem S. (Biochem. J. 2001)
    732. Ryanoid modification of the cardiac muscle ryanodine receptor channel results in relocation of the tetraethylammonium binding site. (PubMed id 11331348)9 Tanna B....Williams A.J. (J. Gen. Physiol. 2001)
    733. Ryanodine-sensitive Ca2+ release mechanism in non-excitable cells (Review). (PubMed id 11115603)9 Ozawa T. (Int. J. Mol. Med. 2001)
    734. Structure and targeting of RyR1: implications from fusion of green fluorescent protein at the amino-terminal. (PubMed id 11361129)9 Lorenzon N.M....Beam K.G. (Arch. Biochem. Biophys. 2001)
    735. Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. (PubMed id 11571310)9 Mitchell K.J....Rutter G.A. (J. Cell Biol. 2001)
    736. Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor). (PubMed id 11274202)9 Balshaw D.M....Meissner G. (J. Biol. Chem. 2001)
    737. Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. (PubMed id 11157710)9 Laitinen P.J.... Kontula K. (Circulation 2001)
    738. Type 1 and type 3 ryanodine receptors generate different Ca(2+) release event activity in both intact and permeabilized myotubes. (PubMed id 11720987)9 Ward C.W....Schneider M.F. (Biophys. J. 2001)
    739. Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII. (PubMed id 11720989)9 Dulhunty A.F....Gallant E.M. (Biophys. J. 2001)
    740. Multiple effects of caffeine on Ca2+ release and influx in human B lymphocytes. (PubMed id 11162852)9 Sei Y....Daly J.W. (Cell Calcium 2001)
    741. A bioactive metabolite of benzo[a]pyrene, benzo[a]pyrene-7,8-dione, selectively alters microsomal Ca2+ transport and ryanodine receptor function. (PubMed id 11179446)9 Pessah I.N....Feng W. (Mol. Pharmacol. 2001)
    742. cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle. (PubMed id 11123235)9 Li P.L....Campbell W.B. (Am. J. Physiol. Heart Circ. Physiol. 2001)
    743. The complex and intriguing lives of PIP2 with ion channels and transporters. (PubMed id 11734659)9 Hilgemann D.W....Nasuhoglu C. (Sci. STKE 2001)
    744. Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. (PubMed id 11273716)9 Marks A.R. (J. Mol. Cell. Cardiol. 2001)
    745. Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit. (PubMed id 11576544)9 Mouton J....Maulet Y. (FEBS Lett. 2001)
    746. The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different. (PubMed id 11598113)9 Bultynck G....De Smedt H. (J. Biol. Chem. 2001)
    747. ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. (PubMed id 11208908)9 Wong P.W....Pessah I.N. (J. Neurochem. 2001)
    748. Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function. (PubMed id 11278308)9 Sampath V....Caughey W.S. (J. Biol. Chem. 2001)
    749. Functional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (alpha1S) expressing two complementary protein fragments. (PubMed id 11806762)9 Ahern C.A....Coronado R. (BMC Physiol. 2001)
    750. [RyR-bound FKBP12.6 and the modulation]. (PubMed id 15775577)9 Yano M. and Matsuzaki M. (Clin Calcium 2001)
    751. Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers. (PubMed id 11585849)9 Szentesi P....Csernoch L. (J. Gen. Physiol. 2001)
    752. Effect of volatile anesthetics on the force-frequency relation in human ventricular myocardium: the role of the sarcoplasmic reticulum calcium-release channel. (PubMed id 11684985)9 Schotten U....Hanrath P. (Anesthesiology 2001)
    753. Classes of thiols that influence the activity of the skeletal muscle calcium release channel. (PubMed id 11278999)9 Sun J....Meissner G. (J. Biol. Chem. 2001)
    754. Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release system. (PubMed id 11408471)9 Chini E.N. (J. Appl. Physiol. 2001)
    755. Increase of cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca(2+) transients in fertilization of sea urchin eggs. (PubMed id 11714667)9 Kuroda R....Kuroda H. (Development 2001)
    756. FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels. (PubMed id 11557049)9 Carmody M....O'Neill C. (FEBS Lett. 2001)
    757. Effect of Adriamycin on the boundary lipid structure of cytochrome c oxidase: pico-second time-resolved fluorescence depolarization studies. (PubMed id 11011696)9 Das T.K. and Mazumdar S. (Biophys. Chem. 2000)
    758. Excitation-contraction coupling in skeletal muscle: comparisons with cardiac muscle. (PubMed id 10744351)9 Lamb G.D. (amp 2000)
    759. [Receptor diseases in the field of neurology]. (PubMed id 10892286)9 Takamori M. and Maruta T. (Rinsho Byori 2000)
    760. Role of Mg(2+) in Ca(2+)-induced Ca(2+) release through ryanodine receptors of frog skeletal muscle: modulations by adenine nucleotides and caffeine. (PubMed id 10733962)9 Murayama T....Ogawa Y. (Biophys. J. 2000)
    761. Calcium signal transmission between ryanodine receptors and mitochondria. (PubMed id 10809765)9 Szalai G....HajnA^czky G. (J. Biol. Chem. 2000)
    762. Regulation of excitation contraction coupling by insulin-like growth factor-1 in aging skeletal muscle. (PubMed id 10936903)9 Delbono O. (amp 2000)
    763. Putative roles of type 3 ryanodine receptor isoforms (RyR3). (PubMed id 11150732)9 Ogawa Y....Murayama T. (Trends Cardiovasc. Med. 2000)
    764. Characterization of the sarcoplasmic reticulum k(+) and Ca(2+)-release channel-ryanodine receptor-in human atrial cells. (PubMed id 11040108)9 CA'tAc K....Rousseau E. (J. Mol. Cell. Cardiol. 2000)
    765. Characterization of [(3)H]ryanodine binding sites in mammalian lung. (PubMed id 10864448)9 Wild J.S....Pessah I.N. (Arch. Biochem. Biophys. 2000)
    766. Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation. (PubMed id 11343972)9 Ikemoto N. and Yamamoto T. (Trends Cardiovasc. Med. 2000)
    767. Evidence of functional ryanodine receptor involved in apoptosis of prostate cancer (LNCaP) cells. (PubMed id 10797495)9 Mariot P....Skryma R. (Prostate 2000)
    768. The interaction of a neutral ryanoid with the ryanodine receptor channel provides insights into the mechanisms by which ryanoid binding is modulated by voltage. (PubMed id 10871634)9 Tanna B....Williams A.J. (J. Gen. Physiol. 2000)
    769. Calmodulin and immunophilin are required as functional partners of a ryanodine receptor in ascidian oocytes at fertilization. (PubMed id 10964467)9 Albrieux M....Villaz M. (Dev. Biol. 2000)
    770. [Biology of malignant hyperthermia: a disease of the calcium channels of the skeletal muscle]. (PubMed id 10760701)9 Monnier N. and Lunardi J. (Ann. Biol. Clin. (Paris) 2000)
    771. Identification of a novel mutation in the ryanodine receptor gene (RYR1) in a malignant hyperthermia Italian family. (PubMed id 10757649)9 Fortunato G....Carsana A. (Eur. J. Hum. Genet. 2000)
    772. Transmembrane redox sensor of ryanodine receptor complex. (PubMed id 10998414)9 Feng W....Pessah I.N. (J. Biol. Chem. 2000)
    773. FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. (PubMed id 10781282)9 Chini E.N. and Walker H. (Anesthesiology 2000)
    774. Excitation-contraction coupling is not affected by scrambled sequence in residues 681-690 of the dihydropyridine receptor II-III loop. (PubMed id 10915779)9 Proenza C....Beam K.G. (J. Biol. Chem. 2000)
    775. Complement activation by titin and ryanodine receptor autoantibodies in myasthenia gravis. A study of IgG subclasses and clinical correlations. (PubMed id 11063835)9 Romi F....Gilhus N.E. (J. Neuroimmunol. 2000)
    776. Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. (PubMed id 10318964)9 Genazzani A.A....Guerini D. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    777. Mechanisms of delta-hexachlorocyclohexane toxicity: II. Evidence for Ca2+-dependent K+-selective ionophore activity. (PubMed id 10087041)9 Buck E.D. and Pessah I.N. (J. Pharmacol. Exp. Ther. 1999)
    778. The reactions of copper proteins with nitric oxide. (PubMed id 10320665)9 Torres J. and Wilson M.T. (Biochim. Biophys. Acta 1999)
    779. Two novel types of calcium release from skeletal sarcoplasmic reticulum by phosphatidylinositol 4,5-biphosphate. (PubMed id 10535676)9 Ohizumi Y....Kobayashi M. (Can. J. Physiol. Pharmacol. 1999)
    780. Ryanodine receptors in human bladder smooth muscle. (PubMed id 10081705)9 Chambers P....Gillespie J.I. (Exp. Physiol. 1999)
    781. HEK-293 cells possess a carbachol- and thapsigargin-sensitive intracellular Ca2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine. (PubMed id 10493909)9 Tong J....MacLennan D.H. (Biochem. J. 1999)
    782. Calexcitin interaction with neuronal ryanodine receptors. (PubMed id 10393102)9 Nelson T.J....Alkon D.L. (Biochem. J. 1999)
    783. Modal gating transitions in cardiac ryanodine receptors during increases of Ca2+ concentration produced by photolysis of caged Ca2+. (PubMed id 10398857)9 ZahradnA-kovA! A....GyAPrke S. (Pflugers Arch. 1999)
    784. Regulation of ryanodine receptor opening by lumenal Ca(2+) underlies quantal Ca(2+) release in PC12 cells. (PubMed id 10559210)9 Koizumi S....Bootman M.D. (J. Biol. Chem. 1999)
    785. Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR II-III loop: effects of DHPR Ser687 and FKBP12. (PubMed id 10388749)9 Dulhunty A.F....Curtis S. (Biophys. J. 1999)
    786. Rapid activation of the cardiac ryanodine receptor by submillisecond calcium stimuli. (PubMed id 10578015)9 ZahradnA-kovA! A....GyAPrke S. (J. Gen. Physiol. 1999)
    787. Site-selective modification of hyperreactive cysteines of ryanodine receptor complex by quinones. (PubMed id 10220560)9 Feng W....Pessah I.N. (Mol. Pharmacol. 1999)
    788. Local control models of cardiac excitation-contraction coupling. A possible role for allosteric interactions between ryanodine receptors. (PubMed id 10051521)9 Stern M.D....RA-os E. (J. Gen. Physiol. 1999)
    789. Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. (PubMed id 10512814)9 Serysheva I.I....Hamilton S.L. (Biophys. J. 1999)
    790. Calcium signaling molecules in human cerebellum at midgestation and in ataxia. (PubMed id 10213289)9 Zecevic N....Ehrlich B.E. (Early Hum. Dev. 1999)
    791. Calcium handling proteins in isolated spinal motoneurons. (PubMed id 10574226)9 Van Den Bosch L....Robberecht W. (Life Sci. 1999)
    792. Regulation of ryanodine receptors by reactive nitrogen species. (PubMed id 11230795)9 Eu J.P....Meissner G. (Biochem. Pharmacol. 1999)
    793. Modification of ryanodine receptor/Ca2+ release channel with dinitrofluorobenzene. (PubMed id 10432322)9 Hadad N....Shoshan-Barmatz V. (Biochem. J. 1999)
    794. [&quot;The CD38-cyclic ADP-ribose signal system&quot;: molecular mechanism and biological significance]. (PubMed id 10553576)9 Okamoto H. (Nippon Yakurigaku Zasshi 1999)
    795. Calcium pool size modulates the sensitivity of the ryanodine receptor channel and calcium-dependent ATPase of heavy sarcoplasmic reticulum to extravesicular free calcium concentration. (PubMed id 9572473)9 Marie V. and Silva J.E. (J. Cell. Physiol. 1998)
    796. Signal transmission and transduction in excitation-contraction coupling. (PubMed id 9889830)9 Ikemoto N. and el-Hayek R. (Adv. Exp. Med. Biol. 1998)
    797. Developmental changes in human cerebellum: expression of intracellular calcium receptors, calcium-binding proteins, and phosphorylated and nonphosphorylated neurofilament protein. (PubMed id 9651004)9 Milosevic A. and Zecevic N. (J. Comp. Neurol. 1998)
    798. Chronic effects of enalapril and amlodipine on cardiac remodeling in cardiomyopathic hamster hearts. (PubMed id 9700987)9 Watanabe M....Kitabatake A. (J. Cardiovasc. Pharmacol. 1998)
    799. Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins. (PubMed id 10353700)9 Leong P. and MacLennan D.H. (Biochem. Cell Biol. 1998)
    800. Sulfhydryls associated with H2O2-induced channel activation are on luminal side of ryanodine receptors. (PubMed id 9575787)9 Oba T....Yamaguchi M. (Am. J. Physiol. 1998)
    801. Variability in spontaneous subcellular calcium release in guinea-pig ileum smooth muscle cells. (PubMed id 9508832)9 Gordienko D.V....Cannell M.B. (J. Physiol. (Lond.) 1998)
    802. Molecular identification of the ryanodine receptor Ca2+ sensor. (PubMed id 9614063)9 Chen S.R....Zhang L. (J. Biol. Chem. 1998)
    803. Growth hormone preserves cardiac sarcoplasmic reticulum Ca2+ release channels (ryanodine receptors) and enhances cardiac function in cardiomyopathic hamsters. (PubMed id 9876318)9 Ueyama T....Matsuzaki M. (Cardiovasc. Res. 1998)
    804. Expression of ryanodine receptors in human embryonic kidney (HEK293) cells. (PubMed id 9693105)9 Querfurth H.W....Geiger J.D. (Biochem. J. 1998)
    805. Myasthenia gravis sera containing antiryanodine receptor antibodies inhibit binding of [3H]-ryanodine to sarcoplasmic reticulum. (PubMed id 9486861)9 Skeie G.O....Gilhus N.E. (amp 1998)
    806. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. (PubMed id 9461216)9 Shou W....Matzuk M.M. (Nature 1998)
    807. Overexpression of IGF-1 exclusively in skeletal muscle prevents age-related decline in the number of dihydropyridine receptors. (PubMed id 9786885)9 Renganathan M....Delbono O. (J. Biol. Chem. 1998)
    808. Intracellular calcium homeostasis in human primary muscle cells from malignant hyperthermia-susceptible and normal individuals. Effect Of overexpression of recombinant wild-type and Arg163Cys mutated ryanodine receptors. (PubMed id 9502764)9 Censier K....Treves S. (J. Clin. Invest. 1998)
    809. Spontaneous thymoma rat as a model for myasthenic weakness caused by anti-ryanodine receptor antibodies. (PubMed id 9843065)9 Iwasa K....Takamori M. (amp 1998)
    810. FKBP12 modulates gating of the ryanodine receptor/calcium release channel. (PubMed id 10603943)9 Ondrias K....Marks A.R. (Ann. N. Y. Acad. Sci. 1998)
    811. Identification, characterization and partial purification of a thiol-protease which cleaves specifically the skeletal muscle ryanodine receptor/Ca2+ release channel. (PubMed id 9430619)9 Shevchenko S....Shoshan-Barmatz V. (J. Membr. Biol. 1998)
    812. Activation of the cardiac ryanodine receptor by sulfhydryl oxidation is modified by Mg2+ and ATP. (PubMed id 9569245)9 Eager K.R. and Dulhunty A.F. (J. Membr. Biol. 1998)
    813. Potential for pharmacology of ryanodine receptor/calcium release channels. (PubMed id 10603942)9 Xu L....Meissner G. (Ann. N. Y. Acad. Sci. 1998)
    814. Autoimmunity to ryanodine receptor and titin in myasthenia gravis is associated with GM allotypes. (PubMed id 9546812)9 Skeie G.O....Gilhus N.E. (Autoimmunity 1997)
    815. The two intracellular Ca2+ release channels, ryanodine receptor and inositol 1,4,5-trisphosphate receptor, play different roles during fertilization in ascidians. (PubMed id 9299112)9 Albrieux M....Villaz M. (Dev. Biol. 1997)
    816. Calcium channels in neurological disease. (PubMed id 9307247)9 Greenberg D.A. (Ann. Neurol. 1997)
    817. [Structure and pharmacology of ryanodine receptors]. (PubMed id 11038729)9 Zhang X.H. and Zhu P.H. (Sheng Li Ke Xue Jin Zhan 1997)
    818. Involvement of lysine residues in the gating of the ryanodine receptor/Ca2+-release channel of skeletal muscle sarcoplasmic reticulum. (PubMed id 9288920)9 Feng W. and Shoshan-Barmatz V. (Eur. J. Biochem. 1997)
    819. A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle. (PubMed id 9079632)9 Yamazawa T....Iino M. (J. Biol. Chem. 1997)
    820. Differences in sarcoplasmic reticulum gene expression in myocardium from patients undergoing cardiac surgery. Quantification of steady-state levels of messenger RNA using the reverse transcription-polymerase chain reaction. (PubMed id 9288554)9 Ohkusa T....Matsuzaki M. (Heart Vessels 1997)
    821. Functional interactions between cytoplasmic domains of the skeletal muscle Ca2+ release channel. (PubMed id 9312113)9 Wu Y....Hamilton S.L. (J. Biol. Chem. 1997)
    822. Overexpression of hIGF-1 exclusively in skeletal muscle increases the number of dihydropyridine receptors in adult transgenic mice. (PubMed id 9395065)9 Renganathan M....Delbono O. (FEBS Lett. 1997)
    823. Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. (PubMed id 9174102)9 Bianchi C.P. (Biochem. Pharmacol. 1997)
    824. Development of mechanisms regulating intracellular Ca2+ concentration in cardiac muscle cells of early chick embryos. (PubMed id 9205138)9 Komazaki S. and Hiruma T. (Dev. Biol. 1997)
    825. Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. (PubMed id 9234963)9 Franzini-Armstrong C. and Protasi F. (Physiol. Rev. 1997)
    826. Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease. (PubMed id 9334205)9 Tong J....MacLennan D.H. (J. Biol. Chem. 1997)
    827. Gating of the skeletal calcium release channel by ATP is inhibited by protein phosphatase 1 but not by Mg2+. (PubMed id 9160164)9 Sonnleitner A....Schindler H. (Cell Calcium 1997)
    828. Intracellular calcium-release channels: regulators of cell life and death. (PubMed id 9124414)9 Marks A.R. (Am. J. Physiol. 1997)
    829. Molecular cloning and characterization of a human brain ryanodine receptor. (PubMed id 9395096)9 Nakashima Y.... Kita T. (FEBS Lett. 1997)
    830. Regulation of intracellular calcium release channel function by arachidonic acid and leukotriene B4. (PubMed id 9268725)9 Striggow F. and Ehrlich B.E. (Biochem. Biophys. Res. Commun. 1997)
    831. Intracellular calcium signalling in striated muscle cells. (PubMed id 9397486)9 Lunde P.K. and Sejersted O.M. (Scand. J. Clin. Lab. Invest. 1997)
    832. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. (PubMed id 9326287)9 Querfurth H.W....Selkoe D.J. (J. Neurochem. 1997)
    833. [Molecular pathology of malignant hyperthermia and central core disease]. (PubMed id 9436456)9 Takagi A. (Nippon Rinsho 1997)
    834. Unaltered ryanodine receptor protein levels in ischemic cardiomyopathy. (PubMed id 8901486)9 Schillinger W....Hasenfuss G. (Mol. Cell. Biochem. 1996)
    835. Diagnosis of malignant hyperthermia: a comparison of the in vitro contracture test with the molecular genetic diagnosis in a large pedigree. (PubMed id 8825043)9 Healy J.M....McCarthy T.V. (J. Med. Genet. 1996)
    836. Differential distribution of ryanodine receptor type 3 (RyR3) gene product in mammalian skeletal muscles. (PubMed id 8645204)9 Conti A....Sorrentino V. (Biochem. J. 1996)
    837. Selective binding of FKBP12.6 by the cardiac ryanodine receptor. (PubMed id 8702774)9 Timerman A.P....Fleischer S. (J. Biol. Chem. 1996)
    838. Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers. (PubMed id 8843711)9 Oba T....Van Helden D.F. (Am. J. Physiol. 1996)
    839. Cytochrome c oxidase deficiency in fibroblasts of a patient with mitochondrial encephalomyopathy. (PubMed id 8918062)9 Lee W.T....Shen Y.Z. (J. Formos. Med. Assoc. 1996)
    840. Activation of the skeletal muscle ryanodine receptor by suramin and suramin analogs. (PubMed id 8967964)9 Hohenegger M....Freissmuth M. (Mol. Pharmacol. 1996)
    841. The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis. (PubMed id 8809036)9 Tunwell R.E.A.... Lai F.A. (Biochem. J. 1996)
    842. Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle. (PubMed id 8755610)9 Flucher B.E. and Franzini-Armstrong C. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    843. Ryanodine receptor/calcium release channel conformations as reflected in the different effects of propranolol on its ryanodine binding and channel activity. (PubMed id 8615803)9 Zchut S....Shoshan-Barmatz V. (Biochem. J. 1996)
    844. Formation of triads without the dihydropyridine receptor alpha subunits in cell lines from dysgenic skeletal muscle. (PubMed id 8707823)9 Powell J.A....Flucher B.E. (J. Cell Biol. 1996)
    845. Resonance Raman/absorption characterization of the oxo intermediates of cytochrome c oxidase generated in its reaction with hydrogen peroxide: pH and H2O2 concentration dependence. (PubMed id 8679619)9 Proshlyakov D.A....Kitagawa T. (Biochemistry 1996)
    846. 4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor. (PubMed id 8605229)9 Herrmann-Frank A....Lehmann-Horn F. (Biochim. Biophys. Acta 1996)
    847. Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. (PubMed id 8635249)9 Kaftan E....Ehrlich B.E. (Circ. Res. 1996)
    848. The role of the skeletal muscle ryanodine receptor (RYR1) gene in malignant hyperthermia and central core disease. (PubMed id 7676327)9 MacLennan D.H. and Phillips M.S. (Soc. Gen. Physiol. Ser. 1995)
    849. Activation and labelling of the purified skeletal muscle ryanodine receptor by an oxidized ATP analogue. (PubMed id 7755553)9 Hohenegger M....Lehmann-Horn F. (Biochem. J. 1995)
    850. Phosphorylation with protein kinases modulates calcium loading of terminal cisternae of sarcoplasmic reticulum from skeletal muscle. (PubMed id 8529260)9 Mayrleitner M....Fleischer S. (Cell Calcium 1995)
    851. Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle. (PubMed id 7730402)9 Sun X.H....Franzini-Armstrong C. (J. Cell Biol. 1995)
    852. Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. (PubMed id 7531689)9 Timerman A.P....Fleischer S. (J. Biol. Chem. 1995)
    853. Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel. (PubMed id 7712023)9 McGarry S.J....Williams A.J. (Br. J. Pharmacol. 1995)
    854. Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein. (PubMed id 8599646)9 Ma J....Zhao J. (Biophys. J. 1995)
    855. Understanding the cytochrome c oxidase proton pump: thermodynamics of redox linkage. (PubMed id 7647257)9 Musser S.M. and Chan S.I. (Biophys. J. 1995)
    856. Co-expression in CHO cells of two muscle proteins involved in excitation-contraction coupling. (PubMed id 8567934)9 Takekura H....Franzini-Armstrong C. (J. Muscle Res. Cell. Motil. 1995)
    857. Magnesium ions but not ATP inhibit cyclic ADP-ribose-induced calcium release. (PubMed id 7826401)9 Graeff R.M....Lee H.C. (Biochem. Biophys. Res. Commun. 1995)
    858. [Ryanodine receptors in the central nervous system]. (PubMed id 7557730)9 Ogawa Y. and Murayama T. (Nippon Yakurigaku Zasshi 1995)
    859. The reaction of cyanide with peroxidatic forms of cytochrome oxidase. (PubMed id 7849012)9 Fabian M. and Palmer G. (Biochemistry 1995)
    860. Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia. (PubMed id 8592342)9 O'Brien R.O.... Foster P.S. (J. Med. Genet. 1995)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6261 HGNC: 10483 AceView: RYR1 Ensembl:ENSG00000196218 euGenes: HUgn6261
    ECgene: RYR1 Kegg: 6261 H-InvDB: RYR1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RYR1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RYR1[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Ryanodine_receptor
    Wikipedia http://en.wikipedia.org/wiki/RYR1

    (Patent information from GeneIP,
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    Patent Information for RYR1 gene:
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