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Aliases for RYK Gene

Aliases for RYK Gene

  • Receptor-Like Tyrosine Kinase 2 3 5
  • JTK5A Protein Tyrosine Kinase 2 3
  • EC 2.7.10.1 4 61
  • JTK5A 3 4
  • RYK Receptor-Like Tyrosine Kinase 2
  • Tyrosine-Protein Kinase RYK 3
  • Hydroxyaryl-Protein Kinase 3
  • EC 2.7.10 61
  • D3S3195 3
  • JTK5 3
  • RYK1 3

External Ids for RYK Gene

Previous HGNC Symbols for RYK Gene

  • JTK5A

Previous GeneCards Identifiers for RYK Gene

  • GC03P130793
  • GC03M134620
  • GC03M135157
  • GC03M135197
  • GC03M135196
  • GC03M135358
  • GC03M133794
  • GC03M131254

Summaries for RYK Gene

Entrez Gene Summary for RYK Gene

  • The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

GeneCards Summary for RYK Gene

RYK (Receptor-Like Tyrosine Kinase) is a Protein Coding gene. Diseases associated with RYK include Robinow Syndrome, Autosomal Dominant 1 and Multiple Endocrine Neoplasia Iib. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MET.

UniProtKB/Swiss-Prot for RYK Gene

  • May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Gene Wiki entry for RYK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RYK Gene

Genomics for RYK Gene

Regulatory Elements for RYK Gene

Enhancers for RYK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F134224 1 Ensembl ENCODE 29.7 +26.3 26343 1.0 SIN3A FEZF1 ZNF48 ZNF2 ZNF143 FOS ZNF202 ZNF263 MEF2D SMARCA4 RYK TOPBP1 C3orf36 GC03P134171
GH03F133805 0.2 ENCODE 20.1 +444.7 444742 2.0 PKNOX1 ATF1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 SRPRB C3orf36 RYK SLCO2A1 HMGB3P14 LOC105374116 GC03P133813 PIR63043
GH03F134290 1.1 Ensembl ENCODE 18.7 -41.0 -40971 1.7 L3MBTL2 MAX CEBPB CEBPG EP300 RFX5 IRF9 JUND ATF3 CEBPA RYK LINC02004
GH03F134795 0.2 ENCODE 13.7 -545.0 -544953 1.5 HDGF PKNOX1 SIN3A ZNF48 ZNF2 YY1 ZNF121 GLIS2 ZNF143 ZNF207 LOC100421154 RYK HMGB3P14 RPL39P5 RNA5SP141 PIR60355
GH03F134482 0.8 FANTOM5 ENCODE 12.2 -234.4 -234391 6.0 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ANAPC13 CEP63 RYK ENSG00000260633 MIR4788
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RYK on UCSC Golden Path with GeneCards custom track

Promoters for RYK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001374370 443 2401 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ELK1 ZNF207 REST KAT8

Genomic Location for RYK Gene

Chromosome:
3
Start:
134,065,303 bp from pter
End:
134,250,843 bp from pter
Size:
185,541 bases
Orientation:
Minus strand

Genomic View for RYK Gene

Genes around RYK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RYK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RYK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RYK Gene

Proteins for RYK Gene

  • Protein details for RYK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34925-RYK_HUMAN
    Recommended name:
    Tyrosine-protein kinase RYK
    Protein Accession:
    P34925
    Secondary Accessions:
    • Q04696

    Protein attributes for RYK Gene

    Size:
    604 amino acids
    Molecular mass:
    67507 Da
    Quaternary structure:
    • Interacts with DVL1 (via PDZ domain).

    Alternative splice isoforms for RYK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RYK Gene

Selected DME Specific Peptides for RYK Gene

Post-translational modifications for RYK Gene

  • Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
  • Glycosylation at Asn 136, Asn 171, Asn 175, Asn 179, and Asn 206
  • Modification sites at PhosphoSitePlus

Other Protein References for RYK Gene

Antibody Products

Domains & Families for RYK Gene

Suggested Antigen Peptide Sequences for RYK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34925

UniProtKB/Swiss-Prot:

RYK_HUMAN :
  • The extracellular WIF domain is responsible for Wnt binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • The extracellular WIF domain is responsible for Wnt binding.
  • Contains 1 protein kinase domain.
  • Contains 1 WIF domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with RYK: view

Function for RYK Gene

Molecular function for RYK Gene

GENATLAS Biochemistry:
related to receptor tyrosine kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Enzyme Numbers (IUBMB) for RYK Gene

Gene Ontology (GO) - Molecular Function for RYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 NOT protein tyrosine kinase activity IEA,IDA 10454588
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 8386829
GO:0004888 transmembrane signaling receptor activity IDA 10454588
GO:0005109 frizzled binding IEA,NAS 20004982
GO:0005515 protein binding IPI 15454084
genes like me logo Genes that share ontologies with RYK: view
genes like me logo Genes that share phenotypes with RYK: view

Animal Models for RYK Gene

MGI Knock Outs for RYK:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RYK Gene

Localization for RYK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RYK Gene

Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RYK Gene COMPARTMENTS Subcellular localization image for RYK gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 20004982
GO:0005737 cytoplasm IEA,ISS --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 8386829
GO:0016020 membrane IEA,ISS --
genes like me logo Genes that share ontologies with RYK: view

Pathways & Interactions for RYK Gene

genes like me logo Genes that share pathways with RYK: view

Interacting Proteins for RYK Gene

Selected Interacting proteins: P34925-RYK_HUMAN for RYK Gene via IID

SIGNOR curated interactions for RYK Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation IEA,IDA 10454588
GO:0007165 signal transduction TAS 8386829
GO:0007409 axonogenesis IEA,TAS 24431302
GO:0007411 axon guidance IEA,NAS 20004982
GO:0007416 synapse assembly NAS 20004982
genes like me logo Genes that share ontologies with RYK: view

Drugs & Compounds for RYK Gene

(3) Drugs for RYK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for RYK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with RYK: view

Transcripts for RYK Gene

Unigene Clusters for RYK Gene

Receptor-like tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RYK Gene

No ASD Table

Relevant External Links for RYK Gene

GeneLoc Exon Structure for
RYK
ECgene alternative splicing isoforms for
RYK

Expression for RYK Gene

mRNA expression in normal human tissues for RYK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RYK Gene

This gene is overexpressed in Ovary (43.8), Adipocyte (18.9), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RYK Gene



Protein tissue co-expression partners for RYK Gene

NURSA nuclear receptor signaling pathways regulating expression of RYK Gene:

RYK

SOURCE GeneReport for Unigene cluster for RYK Gene:

Hs.654562

mRNA Expression by UniProt/SwissProt for RYK Gene:

P34925-RYK_HUMAN
Tissue specificity: Observed in all the tissues examined.
genes like me logo Genes that share expression patterns with RYK: view

Primer Products

No data available for mRNA differential expression in normal tissues for RYK Gene

Orthologs for RYK Gene

This gene was present in the common ancestor of animals.

Orthologs for RYK Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RYK 34 35
  • 96.31 (n)
cow
(Bos Taurus)
Mammalia RYK 34 35
  • 95.34 (n)
dog
(Canis familiaris)
Mammalia RYK 34 35
  • 94.44 (n)
rat
(Rattus norvegicus)
Mammalia Ryk 34
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Ryk 34 16 35
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia RYK 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RYK 34 35
  • 82.48 (n)
lizard
(Anolis carolinensis)
Reptilia RYK 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ryk 34
  • 73.4 (n)
Str.16124 34
zebrafish
(Danio rerio)
Actinopterygii ryk 34 35
  • 74.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta Drl-2 36 34 35
  • 49.85 (n)
drl 36 35
  • 46 (a)
dnt 36 35
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006405 34
  • 48.86 (n)
worm
(Caenorhabditis elegans)
Secernentea lin-18 36 34 35
  • 45.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToOne
Species where no ortholog for RYK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RYK Gene

ENSEMBL:
Gene Tree for RYK (if available)
TreeFam:
Gene Tree for RYK (if available)

Paralogs for RYK Gene

Paralogs for RYK Gene

Pseudogenes.org Pseudogenes for RYK Gene

genes like me logo Genes that share paralogs with RYK: view

Variants for RYK Gene

Sequence variations from dbSNP and Humsavar for RYK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_041802 An ovarian mucinous carcinoma sample
rs864309561 Benign 134,250,644(-) TGGGG(-/G)CGGCG nc-transcript-variant, reference, frameshift-variant
rs10804626 -- 134,173,988(+) caaaa(C/T)gtgat intron-variant
rs10804627 -- 134,174,028(+) ggatt(A/C)tgtaa intron-variant
rs10804628 -- 134,176,778(+) gggtg(C/T)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RYK Gene

Variant ID Type Subtype PubMed ID
esv23490 CNV loss 19812545
nsv1074626 CNV deletion 25765185
nsv1142373 CNV tandem duplication 24896259
nsv1145001 CNV deletion 24896259
nsv475801 CNV novel sequence insertion 20440878

Variation tolerance for RYK Gene

Gene Damage Index Score: 9.00; 87.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RYK Gene

Human Gene Mutation Database (HGMD)
RYK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RYK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RYK Gene

Disorders for RYK Gene

MalaCards: The human disease database

(2) MalaCards diseases for RYK Gene - From: DISEASES

Disorder Aliases PubMed IDs
robinow syndrome, autosomal dominant 1
  • robinow syndrome
multiple endocrine neoplasia iib
  • multiple endocrine neoplasia, type iib
- elite association - COSMIC cancer census association via MalaCards
Search RYK in MalaCards View complete list of genes associated with diseases

Relevant External Links for RYK

Genetic Association Database (GAD)
RYK
Human Genome Epidemiology (HuGE) Navigator
RYK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RYK
genes like me logo Genes that share disorders with RYK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RYK Gene

Publications for RYK Gene

  1. Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). (PMID: 8386829) Stacker S.A. … Wilks A.F. (Oncogene 1993) 2 3 4 22 64
  2. A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. (PMID: 16681403) Watanabe A. … Yoshiura K. (Cleft Palate Craniofac. J. 2006) 3 22 46 64
  3. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PMID: 19937600) Carter T.C. … Mills J.L. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010) 3 46 64
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  5. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. (PMID: 15454084) Lu W. … Baltimore D. (Cell 2004) 3 4 64

Products for RYK Gene

Sources for RYK Gene

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