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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RYK Gene

protein-coding   GIFtS: 66
GCID: GC03M133794

Receptor-Like Tyrosine Kinase

(Previous names: JTK5A protein tyrosine kinase, RYK receptor-like tyrosine...)
(Previous symbol: JTK5A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor-Like Tyrosine Kinase1 2     JTK52
JTK5A1 2 3     RYK12
JTK5A Protein Tyrosine Kinase1 2     Hydroxyaryl-Protein Kinase2
EC 2.7.10.13 8     Tyrosine-Protein Kinase RYK2
RYK Receptor-Like Tyrosine Kinase1     EC 2.7.108
D3S31952     

External Ids:    HGNC: 104811   Entrez Gene: 62592   Ensembl: ENSG000001637857   OMIM: 6005245   UniProtKB: P349253   

Export aliases for RYK gene to outside databases

Previous GC identifers: GC03P130793 GC03M134620 GC03M135157 GC03M135197 GC03M135196 GC03M135358 GC03M131254


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RYK Gene:
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine
kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding
domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation
in the activation segment. It has been suggested that mediation of biological activity by recruitment of a
signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein
has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an
intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the
regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct
isoforms. (provided by RefSeq, Feb 2012)

GeneCards Summary for RYK Gene: 
RYK (receptor-like tyrosine kinase) is a protein-coding gene. Diseases associated with RYK include cleft lip, and cleft palate, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
Function: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in
neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3
stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal
intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal
development

Gene Wiki entry for RYK (Related to receptor tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RYK gene promoter:
         AML1a   HOXA3   AP-1   ATF-2   c-Jun   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRYK promoter sequence
   Search SABiosciences Chromatin IP Primers for RYK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RYK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q22.1

RYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RYK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M133794:  view genomic region     (about GC identifiers)

Start:
133,784,147 bp from pter      End:
133,969,689 bp from pter
Size:
185,543 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RYK_HUMAN, P34925 (See protein sequence)
Recommended Name: Tyrosine-protein kinase RYK precursor  
Size: 604 amino acids; 67507 Da
Subunit: Interacts with DVL1 (via PDZ domain)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity).
Cytoplasm (By similarity). Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved
part is translocated from the cytoplasm to the nucleus (By similarity)
Caution: According to some authors, has impaired kinase activity (PubMed:10454588)
Secondary accessions: Q04696
Alternative splicing: 2 isoforms:  P34925-1   P34925-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RYK: NX_P34925

Explore proteomics data for RYK at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal
    differentiation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P34925

  • 2 DME Specific Peptides for RYK (P34925)
     WMALESL  SDVWAFGVT 

    RYK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RYK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005861.1  NP_002949.2  

    ENSEMBL proteins: 
     ENSP00000475203   ENSP00000419122   ENSP00000417836   ENSP00000296084   ENSP00000399527  

    Human Recombinant Protein Products for RYK: 
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    Cloud-Clone Corp. Proteins for RYK 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS8386829
    GO:0016020membrane ISS--

    RYK for ontologies           About GeneDecksing



    RYK Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor-like tyrosine kinase 
    ROR family and other RTKs
    Ryk family

    5/6 InterPro protein domains (see all 6):
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_kinase_AS
     IPR020635 Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P34925

    ProtoNet protein and cluster: P34925

    2 Blocks protein domains:
    IPB003306 WIF domain
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
    Domain: The extracellular WIF domain is responsible for Wnt binding (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 WIF domain


    RYK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RYK_HUMAN, P34925
    Function: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in
    neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3
    stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal
    intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal
    development
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for RYK:
    related to receptor tyrosine kinase

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713NOT protein tyrosine kinase activity IDA10454588
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS8386829
    GO:0004888transmembrane signaling receptor activity IDA10454588
    GO:0005109frizzled binding IEA--
         
    RYK for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RYK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability in CMK cel  Increased cell death HMECs cel 
     Increased telomerase activity  Synthetic lethal with imatinib 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ryk):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  skeleton  vision/eye 

    RYK for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RYK 
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    miRNA
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    hsa-mir-124 (MIRT002602)

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    hsa-miR-3910 hsa-miR-4307 hsa-miR-548s hsa-miR-548g hsa-miR-124 hsa-miR-7-1* hsa-miR-548x hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidRYK 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RYK About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RYK
        Wnt Signaling Pathway

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RYK (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 BioSystems Pathway for RYK
        Wnt signaling network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RYK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for RYK (P349253 ENSP000002960844) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT1P046283, ENSP000002935494I2D: score=3 STRING: ENSP00000293549
    ABI1Q8IZP03, ENSP000003653124I2D: score=1 STRING: ENSP00000365312
    AIFM1O958313, ENSP000002872954I2D: score=1 STRING: ENSP00000287295
    CDH2P190223, ENSP000002691414I2D: score=1 STRING: ENSP00000269141
    CDHR1Q96JP93, ENSP000003611894I2D: score=1 STRING: ENSP00000361189
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation IDA10454588
    GO:0007165signal transduction TAS8386829
    GO:0007409axonogenesis ----
    GO:0007411axon guidance ISS--
    GO:0016055Wnt receptor signaling pathway IEA--

    RYK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RYK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RYK

    2 HMDB Compounds for RYK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for RYK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 40.9 12 8386829 (6), 19168282 (1), 11150355 (1), 17616647 (1) (see all 5)
    atp 24 2 16168228 (1), 19168282 (1)

    Search CenterWatch for drugs/clinical trials and news about RYK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RYK gene (2 alternative transcripts): 
    NM_001005861.2  NM_002958.3  

    Unigene Cluster for RYK:

    Receptor-like tyrosine kinase
    Hs.654562  [show with all ESTs]
    Unigene Representative Sequence: AB209405
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484106 ENST00000472234 ENST00000460933 ENST00000473208 ENST00000486725
    ENST00000481382 ENST00000480381 ENST00000464879 ENST00000296084 ENST00000427044(uc003eqd.1 uc003eqc.1)

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    Additional mRNA sequence: 

    AB209405.1 BC021700.2 S59184.1 X69970.1 X96588.1 

    11 DOTS entries:

    DT.448866  DT.100018689  DT.100751747  DT.95128704  DT.120856239  DT.95273746  DT.97860722  DT.99962173 
    DT.100751748  DT.120856258  DT.99938697 

    24/208 AceView cDNA sequences (see all 208):

    BG762507 BF447316 BF447237 BE742349 BP336720 BF691623 BU618430 BF977221 
    BG779222 AU130782 AA909901 BM759878 CK820981 W61159 CF272241 BC021700 
    CF139750 BG260940 BG482812 BF978409 CA388839 BM705395 BI793038 AA906125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RYK expression in normal human tissues (normalized intensities)      RYK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACTGTT
    RYK Expression
    About this image


    RYK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Cerebral Cortex
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             fetal cartilage   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See RYK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RYK

    SOURCE GeneReport for Unigene cluster: Hs.654562

    UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
    Tissue specificity: Observed in all the tissues examined

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RYK gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ryk1 , 5 receptor-like tyrosine kinase1, 5 90(n)1
    95.59(a)1
      9 (54.72 cM)5
    201871  NM_013649.31  NP_038677.31 
     1028349175 
    chicken
    (Gallus gallus)
    Aves RYK1 RYK receptor-like tyrosine kinase 81.69(n)
    90.64(a)
      395409  XM_422674.3  XP_422674.3 
    lizard
    (Anolis carolinensis)
    Reptilia RYK6
    receptor-like tyrosine kinase
    85(a)
    1 ↔ 1
    3(31231349-31269889)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.161242 Transcribed sequence with moderate similarity to protein more 75.69(n)    BX748741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ryk1 receptor-like tyrosine kinase 71.36(n)
    77.68(a)
      558502  NM_001083826.1  NP_001077295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta drl3
    Drl-21
    protein amino acid phosphorylation
    transmembrane more3
    Derailed 21
    46(a)
    (best of 3)3
    48.17(n)1
    37.96(a)1
      2 37C73
    364361  NM_136991.31  NP_610835.21 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-181 , 3 protein tyrosine kinase3
    Protein LIN-181
    29(a)3
    45.18(n)1
    33.46(a)1
      X(3993911-3997072)3
    1806791  NM_076283.31  NP_508684.31 


    ENSEMBL Gene Tree for RYK (if available)
    TreeFam Gene Tree for RYK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RYK gene
    AXL2  MET2  TYRO32  MERTK2  MST1R2  
    18/76 SIMAP similar genes for RYK using alignment to 5 protein entries:     RYK_HUMAN (see all proteins) (see all similar genes):
    EPHA4    FLT4    MET    EPHA2    TYK2    ABL1
    AXL    PTK7    DKFZp434L0319    MERTK    MST1R    INSR
    FGR    IGF1R    BTK kinase deficient isoform 6    CD74/ROS fusion    EZR-ROS1    LRIG3(NM_001136051)-ROS1

    RYK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RYK
    PGOHUM00000259202


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1909 SNPs in RYK are shown (see all 1909)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418024
    An ovarian mucinous carcinoma sample4--see VAR_0418022 V I mis40--------
    VAR_0418014
    ----see VAR_0418012 R C mis40--------
    VAR_0418004
    ----see VAR_0418002 N S mis40--------
    rs1413716571,2
    C--131274144(+) ACAGC-/AAAAAA 2 -- int10--------
    rs2013991841,2
    C--131310338(+) AACACA/TGTTGC 2 -- int10--------
    rs114258391,2
    C--131312837(+) AAAAAA/-GAAAA 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1500824451,2
    --133856776(+) CTTACC/TTGTGG 2 -- ds50010--------
    rs1387734301,2
    --133856890(+) TACCTC/GTGAAG 2 -- ds50010--------
    rs1427471571,2
    --133856951(+) CAACTA/CTGCTT 2 -- ds50010--------
    rs145331,2
    C,F,H--133857284(-) AGGCTG/AGCTTA 2 -- ut31 ese35Minor allele frequency- A:0.11MN NA CSA EA 428

    HapMap Linkage Disequilibrium report for RYK (133784147 - 133969689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RYK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv23490CNV Loss19812545


    Human Gene Mutation Database (HGMD): RYK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RYK
    DNA2.0 Custom Variant and Variant Library Synthesis for RYK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600524    OMIM disorders: --

    12 diseases for RYK:    About MalaCards
    cleft lip    cleft palate    chronic myeloid leukemia    myeloid leukemia
    pancreatic cancer    pancreatitis    ovarian cancer    adenocarcinoma
    leukemia    prostatitis    neuronitis    breast cancer


    RYK for disorders           About GeneDecksing

    Genetic Association Database (GAD): RYK
    Human Genome Epidemiology (HuGE) Navigator: RYK (13 documents)

    Export disorders for RYK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RYK gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with RYK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). (PubMed id 8386829)1, 2, 3, 9 Stacker S.A.... Wilks A.F. (1993)
    2. A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. (PubMed id 16681403)1, 4, 9 Watanabe A....Yoshiura K. (2006)
    3. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    4. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PubMed id 19937600)1, 4 Carter T.C....Mills J.L. (2010)
    5. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. (PubMed id 15454084)1, 2 Lu W....Baltimore D. (2004)
    6. Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. (PubMed id 10454588)1, 2 Katso R.M....Ganesan T.S. (1999)
    7. H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. (PubMed id 8726462)1, 2 Wang X.C.... Ganesan T.S. (1996)
    8. The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. (PubMed id 8390040)1, 2 Tamagnone L.... Alitalo K. (1993)
    9. The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. (PubMed id 22773843)1 Macheda M.L....Stacker S.A. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6259 HGNC: 10481 AceView: RYK Ensembl:ENSG00000163785 euGenes: HUgn6259
    ECgene: RYK H-InvDB: RYK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RYK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RYK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RYK gene:
    Search GeneIP for patents involving RYK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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