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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RYK Gene

protein-coding   GIFtS: 63
GCID: GC03M133794

receptor-like tyrosine kinase

(Previous names: JTK5A protein tyrosine kinase, RYK receptor-like tyrosine...)
(Previous symbol: JTK5A)
 Explore 16 diseases affiliated with
RYK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RYK    

Aliases
for RYK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Receptor-Like Tyrosine Kinase1 2     EC 2.7.10.13 8
JTK5A1 2 3     RYK Receptor-Like Tyrosine Kinase1
D3S31951 2     Hydroxyaryl-Protein Kinase2
JTK51 2     Tyrosine-Protein Kinase RYK2
RYK11 2     EC 2.7.108
JTK5A Protein Tyrosine Kinase1 2     

External Ids:    HGNC: 104811   Entrez Gene: 62592   Ensembl: ENSG000001637857   OMIM: 6005245   UniProtKB: P349253   

Export aliases for RYK gene to outside databases

Previous GC identifers: GC03P130793 GC03M134620 GC03M135157 GC03M135197 GC03M135196 GC03M135358 GC03M131254


Summaries
for RYK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RYK:
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine
kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding
domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in
the activation segment. It has been suggested that mediation of biological activity by recruitment of a
signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a
leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an
intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the
regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct
isoforms. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
Function: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron
differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation,
receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to
translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development

Gene Wiki entry for RYK (Related to receptor tyrosine kinase)


Genomic Views
for RYK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RYK gene promoter:
         AML1a   HOXA3   AP-1   ATF-2   c-Jun   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RYK promoter sequence
   Search SABiosciences Chromatin IP Primers for RYK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RYK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q22.1

RYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RYK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M133794:  view genomic region     (about GC identifiers)

Start:
 133,794,023 bp from pter      End:
 133,969,689 bp from pter
Size:
 175,667 bases      Orientation:
 minus strand

Proteins
for RYK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RYK_HUMAN, P34925 (See protein sequence)
Recommended Name: Tyrosine-protein kinase RYK precursor  
Size: 604 amino acids; 67507 Da
Subunit: Interacts with DVL1 (via PDZ domain)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity). Cytoplasm
(By similarity). Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is
translocated from the cytoplasm to the nucleus (By similarity)
Caution: According to some authors, has impaired kinase activity (PubMed:10454588)
Secondary accessions: Q04696
Alternative splicing: 2 isoforms:  P34925-1   P34925-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RYK: NX_P34925

Post-translational modifications:

  • Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal
    • differentiation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34925

    • 2 DME Specific Peptides for RYK (P34925)
     WMALESL  SDVWAFGVT 

    RYK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005861.1  NP_002949.2  

    ENSEMBL proteins: 
     ENSP00000419122   ENSP00000417836   ENSP00000296084   ENSP00000399527  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for RYK
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): RYK
    OriGene Protein Over-expression Lysate (see all 3): RYK
    OriGene Custom Protein Services for RYK 
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    Novus Biologicals RYK Protein
    Novus Biologicals RYK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RYK

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS8386829


    RYK for ontologies           About GeneDecksing



    RYK Antibody Products: 
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    R&D Systems Antibodies for RYK
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    Novus Biologicals RYK Antibodies
    Abcam antibodies for RYK 
    Uscn Antibodies for RYK
    ThermoFisher Antibody for RYK

    Assay Products for RYK: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RYK

    Protein Domains /
    Families
    for RYK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RYK for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_kinase_AS
     IPR020635 Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P34925

    ProtoNet protein and cluster: P34925

    2 Blocks protein families:
    IPB003306 WIF domain
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
    Domain: The extracellular WIF domain is responsible for Wnt binding (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 WIF domain


    Function
    for RYK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
    Function: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron
    differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation,
    receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to
    translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for RYK:
    related to receptor tyrosine kinase

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target RYK:
    hsa-mir-124 (MIRT002602)

    OriGene 3'-UTR Clone (see all 2): RYK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RYK
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RYK (see all 17):
    hsa-miR-3910 hsa-miR-4307 hsa-miR-548s hsa-miR-548g hsa-miR-124 hsa-miR-7-1* hsa-miR-548x hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: RYK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RYK (see all 7)
    OriGene shRNA RFP: RYK
    OriGene siRNA: RYK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RYK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RYK

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RYK (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RYK (see all 3)
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    GenScript: all cDNA clones in your preferred vector (see all 2): RYK (NM_001005861)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RYK 

    Cell Line
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    Search LifeMap BioReagents cell lines for RYK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYK

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713NOT protein tyrosine kinase activity IDA10454588
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0004888transmembrane signaling receptor activity IDA10454588
    GO:0005109frizzled binding IEA--
    GO:0005515protein binding IPI15454084


    RYK for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RYK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability in CMK cel  Increased cell death HMECs cel 
     Increased telomerase activity  Synthetic lethal with imatinib 

    Animal Models:
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ryk):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  skeleton  vision/eye 

    RYK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RYK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for RYK
        Wnt Signaling Pathway

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RYK (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 BioSystems Pathway for RYK 
        Wnt signaling network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RYK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for RYK (P349253 ENSP000002960844) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT1P046283, ENSP000002935494I2D: score=3 STRING: ENSP00000293549
    ABI1Q8IZP03, ENSP000003653124I2D: score=1 STRING: ENSP00000365312
    AIFM1O958313, ENSP000002872954I2D: score=1 STRING: ENSP00000287295
    CDH2P190223, ENSP000002691414I2D: score=1 STRING: ENSP00000269141
    CDHR1Q96JP93, ENSP000003611894I2D: score=1 STRING: ENSP00000361189
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation IDA10454588
    GO:0007165signal transduction TAS8386829
    GO:0007409axonogenesis ----
    GO:0007411axon guidance ISS--
    GO:0016055Wnt receptor signaling pathway IEA--


    RYK for ontologies           About GeneDecksing



    Drugs & Compounds
    for RYK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RYK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RYK

    2 HMDB Compounds for RYK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    2 Novoseek chemical compound relationships for RYK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 40.9 12 8386829 (6), 19168282 (1), 11150355 (1), 17616647 (1) (see all 5)
    atp 24 2 16168228 (1), 19168282 (1)

    Search CenterWatch for drugs/clinical trials and news about RYK 

    Transcripts
    for RYK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RYK gene (2 alternative transcripts): 
    NM_001005861.2  NM_002958.3  

    Unigene Cluster for RYK:

    Receptor-like tyrosine kinase
    Hs.654562  [show with all ESTs]
    Unigene Representative Sequence: AB209405
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472234 ENST00000460933 ENST00000473208 ENST00000486725 ENST00000481382
    ENST00000480381 ENST00000464879 ENST00000296084 ENST00000427044(uc003eqd.1 uc003eqc.1)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RYK
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    hsa-miR-3910 hsa-miR-4307 hsa-miR-548s hsa-miR-548g hsa-miR-124 hsa-miR-7-1* hsa-miR-548x hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: RYK 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RYK (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209405.1 BC021700.2 S59184.1 X69970.1 X96588.1 

    11 DOTS entries:

    DT.448866  DT.100018689  DT.100751747  DT.95128704  DT.120856239  DT.95273746  DT.97860722  DT.99962173 
    DT.100751748  DT.120856258  DT.99938697 

    24/208 AceView cDNA sequences (see all 208):

    AA909901 BE742349 CA388838 CF139750 BE857247 BQ434679 AA024438 BM763208 
    BG762507 BF691623 BG779222 BM759878 BU618430 BC021700 W61159 BG260940 
    BP336720 AU130782 CK820981 BM705395 BI793038 AL709669 AA906125 CF272241 

    GeneLoc Exon Structure


    Expression
    for RYK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RYK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAACTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RYK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RYK

    SOURCE GeneReport for Unigene cluster: Hs.654562

    UniProtKB/Swiss-Prot: RYK_HUMAN, P34925
    Tissue specificity: Observed in all the tissues examined

        SABiosciences Custom PCR Arrays for RYK
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RYK
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYK

    Orthologs
    for RYK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RYK gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RYK1 RYK receptor-like tyrosine kinase 81.69(n)
    90.64(a)    		   395409  XM_422674.3  XP_422674.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RYK6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(31231349-31254578)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.161242 Transcribed sequence with moderate similarity to protein more 75.69(n)    BX748741.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ryk1 receptor-like tyrosine kinase 71.36(n)
    77.68(a)    		   558502  NM_001083826.1  NP_001077295.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta drl3
    Drl-21    		 protein amino acid phosphorylation
    transmembrane more3
    Derailed 21    		 46(a)
    (best of 3)3
    48.17(n)1
    37.96(a)1    		   2 37C73
    364361  NM_136991.31  NP_610835.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-181 , 3 protein tyrosine kinase3
    Protein LIN-181    		 29(a)3
    45.18(n)1
    33.46(a)1    		   X(3993911-3997072)3
    1806791  NM_076283.31  NP_508684.31 


    ENSEMBL Gene Tree for RYK (if available)
    TreeFam Gene Tree for RYK (if available) 

    Paralogs
    for RYK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RYK gene
    AXL2  TIE12  MET2  TEK2  TYRO32  MERTK2  MST1R2  
    18/54 SIMAP similar genes for RYK using alignment to 5 protein entries:     RYK_HUMAN (see all proteins) (see all similar genes):
    EPHA4    FLT4    MET    EPHA2    TYK2    ABL1
    AXL    PTK7    DKFZp434L0319    MERTK    MST1R    INSR
    FGR    IGF1R    BTK kinase deficient isoform 6    CD74/ROS fusion    EZR-ROS1    NTRK1

    RYK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RYK
    PGOHUM00000259202


    Genomic Variants
    for RYK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1536 NCBI SNPs in RYK are shown (see all 1536)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs145321,2
    		--131254063(+) ATAAAA/GGGGAA 2 -- ut312Minor allele frequency- G:0.02MN NA 186
    rs557816131,2
    		C--131254301(+) CATGCA/GAGGGC 2 -- ut310--------
    rs729844831,2
    		C,--131254538(+) CTTGAT/AGAAGT 2 -- ut313Minor allele frequency- A:0.12WA 122
    rs561497241,2
    		C--131254953(+) TTAGGC/TACTGT 4 Y C mis10--------
    rs560887021,2
    		C,F,--131255029(+) TCTGCA/GGAGTG 2 -- int12Minor allele frequency- G:0.14NA EU 689
    rs743260931,2
    		--131256202(+) ACAGCC/TAGCTA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs776405861,2
    		C,F,--131256283(+) ATACAC/TAGTTA 2 -- int11Minor allele frequency- T:0.08WA 118
    rs766004821,2
    		F,--131257262(+) GCCTTA/GTAATA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs783248731,2
    		--131258499(+) CTACAA/TCTATT 2 -- int10--------
    rs794079241,2
    		--131258554(+) TCAACA/GCTGTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for RYK (133794023 - 133969689 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RYK
         1 Indel: 68470
    Human Gene Mutation Database (HGMD): RYK

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    Disorders / Diseases
    for RYK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RYK for disorders           About GeneDecksing

    OMIM gene information: 600524    OMIM disorders: --

    16 diseases for RYK:    About MalaCards
    cleft lip/palate    cleft lip    corpus callosum    cleft palate
    chronic myeloid leukemia    myeloid leukemia    ovarian cancer    pancreatic cancer
    prostate carcinoma    leukemia    pancreatitis    prostatitis
    carcinoma    neuronitis    breast cancer    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: RYK (13 documents)

    Export disorders for RYK gene to outside databases

    Publications
    for RYK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RYK gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with RYK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). (PubMed id 8386829)1, 2, 3, 9 Stacker S.A.... Wilks A.F. (1993)
    2. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. (PubMed id 15454084)1, 2 Lu W....Baltimore D. (2004)
    3. Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. (PubMed id 10454588)1, 2 Katso R.M....Ganesan T.S. (1999)
    4. H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. (PubMed id 8726462)1, 2 Wang X.C.... Ganesan T.S. (1996)
    5. The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. (PubMed id 8390040)1, 2 Tamagnone L.... Alitalo K. (1993)
    6. A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. (PubMed id 16681403)1, 9 Watanabe A....Yoshiura K. (2006)
    7. The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. (PubMed id 22773843)1 Macheda M.L....Stacker S.A. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
    10. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)

    External Searches for RYK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RYK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6259 HGNC: 10481 AceView: RYK Ensembl:ENSG00000163785 euGenes: HUgn6259
    ECgene: RYK H-InvDB: RYK

    Other Databases showing RYK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RYK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RYK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RYK Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RYK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RYK gene:
    Search GeneIP for patents involving RYK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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