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RYBP Gene

protein-coding   GIFtS: 60
GCID: GC03M072420

RING1 And YY1 Binding Protein

  Search for RYBP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RING1 And YY1 Binding Protein1 2     APAP-12 3
Apoptin-Associating Protein 11 2 3     DEDAF2 3
Death Effector Domain-Associated Factor1 2 3     DED-Associated Factor2 3
YEAF12 3 5     YY1 And E4TF1-Associated Factor 12 3
Ring1 Interactor RYBP1 2     AAP12
YY1 And E4TF1 Associated Factor 11 2     RING1 And YY1-Binding Protein2

External Ids:    HGNC: 104801   Entrez Gene: 234292   Ensembl: ENSG000001636027   OMIM: 6075355   UniProtKB: Q8N4883   

Export aliases for RYBP gene to outside databases

Previous GC identifers: GC03M070917 GC03M072035 GC03M072229 GC03M072344 GC03M072506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RYBP Gene:
RYBP (RING1 and YY1 binding protein) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is YAF2.

UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating
transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of
the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis

Gene Wiki entry for RYBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RYBP gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RYBP promoter sequence
   Search Chromatin IP Primers for RYBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RYBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p13   Ensembl cytogenetic band:  3p13   HGNC cytogenetic band: 3p14.2

RYBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RYBP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M072420:  view genomic region     (about GC identifiers)

Start:
72,420,976 bp from pter      End:
72,496,069 bp from pter
Size:
75,094 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488 (See protein sequence)
Recommended Name: RING1 and YY1-binding protein  
Size: 228 amino acids; 24822 Da
Subunit: Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR
complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together
with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription
factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins.
Interacts with ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits
ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP
Sequence caution: Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA89486.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for RYBP:
3IXS (3D)    
Secondary accessions: Q9P2W5 Q9UMW4

Explore the universe of human proteins at neXtProt for RYBP: NX_Q8N488

Explore proteomics data for RYBP at MOPED

Post-translational modifications: 

  • Monoubiquitinated (By similarity)1
  • Ubiquitination2 at Lys119
  • Modification sites at PhosphoSitePlus

  • See RYBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036366.3  
    ENSEMBL proteins: 
     ENSP00000419494  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8N488

    ProtoNet protein and cluster: Q8N488

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Domain: Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By
    similarity)
    Similarity: Contains 1 RanBP2-type zinc finger


    Find genes that share domains with RYBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RYBP_HUMAN, Q8N488
    Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating
    transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of
    the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RYBP           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rybp):
     embryogenesis  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system  vision/eye 

    Find genes that share phenotypes with RYBP           About GenesLikeMe

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate RYBP (see all 139):
    hsa-miR-411* hsa-miR-376b hsa-miR-106a hsa-miR-517a hsa-miR-4305 hsa-miR-128 hsa-miR-3074-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidRYBP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RYBP_HUMAN, Q8N488: Nucleus. Cytoplasm. Nucleus, nucleoplasm (By similarity). Note=Primarily found in the
    nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IEA--
    GO:0031519colocalizes with PcG protein complex IDA16943429

    Find genes that share ontologies with RYBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RYBP About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    2E2F transcription factor network
    E2F transcription factor network


    1 BioSystems Pathway for RYBP
        E2F transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Arrays including RYBP: 
              TGFB Signaling Targets in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RYBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RYBP (Q8N4881, 2, 3 ENSP000004194944) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-752324,EBI-389668 MINT-7013717 MINT-7013897 MINT-7013883 MINT-7013688 MINT-7013847 MINT-7013745 MINT-7013780 MINT-7013760 MINT-7013730 MINT-7013864 MINT-7013672 I2D: score=2 STRING: ENSP00000417281
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 STRING: ENSP00000396439
    RING1Q065871, 2, 3, ENSP000003637874EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 STRING: ENSP00000363787
    ENSG00000206287Q065871, 2, 3EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 
    ENSG00000226788Q065871, 2, 3EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0007275multicellular organismal development TAS10369680
    GO:0035518histone H2A monoubiquitination IDA16943429

    Find genes that share ontologies with RYBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RYBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RYBP gene: 
    NM_012234.6  

    Unigene Cluster for RYBP:

    RING1 and YY1 binding protein
    Hs.7910  [show with all ESTs]
    Unigene Representative Sequence: AB029551
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000477973(uc003dpe.3)
    miRNA
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    hsa-miR-411* hsa-miR-376b hsa-miR-106a hsa-miR-517a hsa-miR-4305 hsa-miR-128 hsa-miR-3074-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidRYBP 3' UTR sequence
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    Additional mRNA sequence: 

    AB029551.1 AF085840.1 AF179286.1 AF227959.1 AL049940.1 AY228125.1 BC014959.1 BC036459.1 

    8 DOTS entries:

    DT.99968398  DT.455921  DT.100762428  DT.95153477  DT.120899217  DT.100787136  DT.100787133  DT.100787137 

    Selected AceView cDNA sequences (see all 430):

    AI381628 AW089190 BM718962 AI418277 AA927936 AI096521 AI146559 AI219693 
    AW193683 AI741384 AI220018 AA736848 T32793 AA454192 BF446236 BE857503 
    BF436182 BU166845 AI831906 BM142476 AA811691 AI263823 BF436306 AW590618 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RYBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTACAAA
    RYBP Expression
    About this image


    RYBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
    RYBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RYBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7910

    UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Tissue specificity: Widely expressed with highest levels in lymphoid tissues and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RYBP: 
              TGFB Signaling Targets in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RYBP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rybp1 , 5 RING1 and YY1 binding protein1, 5 93.71(n)1
    99.12(a)1
      6 (46.62 cM)5
    563531  NM_019743.31  NP_062717.21 
     1002285655 
    chicken
    (Gallus gallus)
    Aves RYBP1 RING1 and YY1 binding protein 87.52(n)
    96.35(a)
      416095  XM_414428.4  XP_414428.4 
    lizard
    (Anolis carolinensis)
    Reptilia RYBP6
    RING1 and YY1 binding protein
    90(a)
    1 ↔ 1
    2(179654002-179720103)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.78622 Xenopus laevis transcribed sequence with weak similarity to protein refNP_005739.1 (H.sapiens) YY1 associated factor 2 [Homo sapiens] less 81.19(n)    BJ072372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rybp2 RING1 and YY1 binding protein 79.24(n)   368248  BC054937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RYBP6
    Ring and YY1 Binding Protein
    51(a)
    1 → many
    2R(18558257-18560717)


    ENSEMBL Gene Tree for RYBP (if available)
    TreeFam Gene Tree for RYBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RYBP gene
    YAF22  
    1 SIMAP similar gene for RYBP using alignment to 2 protein entries:     RYBP_HUMAN (see all proteins):
    YAF2

    Find genes that share paralogs with RYBP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RYBP (see all 1496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378864021,2
    --72423321(+) TAAGTC/GAGCTT 1 -- int10--------
    rs1494503301,2
    --72423441(+) ATTAGC/TATATT 1 -- int10--------
    rs1832804051,2
    --72423442(+) TTAGCA/GTATTT 1 -- int10--------
    rs1879215341,2
    --72423499(+) ACATCA/TTTGCA 1 -- int10--------
    rs1923066611,2
    --72423509(+) AATCTA/CTCTCA 1 -- int10--------
    rs1430874681,2
    --72423702(+) AAAATC/TAACTA 1 -- int10--------
    rs1829625851,2
    --72423745(+) AATAAA/CGATTT 1 -- ut310--------
    rs1878452791,2
    --72423968(+) TTTGAC/TCAGTT 1 -- ut310--------
    rs1929550631,2
    --72424059(+) AGAAAA/CTTCCA 1 -- ut310--------
    rs1843541051,2
    --72424282(+) AAAACC/TGTTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RYBP (72420976 - 72496069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RYBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1338763CNV Deletion17803354
    esv990953CNV Deletion20482838
    esv267750CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607535    OMIM disorders: --


    Find genes that share disorders with RYBP           About GenesLikeMe

    1 Novoseek inferred disease relationship for RYBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 46.7 2 15470680 (1), 16528373 (1)

    Genetic Association Database (GAD): RYBP
    Human Genome Epidemiology (HuGE) Navigator: RYBP (1 document)

    Export disorders for RYBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RYBP gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with RYBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. (PubMed id 11395500)1, 2, 9 Zheng L.... Lenardo M.J. (J. Biol. Chem. 2001)
    2. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (Mol. Cell. Biol. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    5. RYBP stabilizes p53 by modulating MDM2. (PubMed id 19098711)1, 2 Chen D.... Zhang R. (EMBO Rep. 2009)
    6. Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. (PubMed id 14765135)1, 2 Danen-van Oorschot A.A.M.M.... Noteborn M.H.M. (Cell Death Differ. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. (PubMed id 11953439)1, 2 Sawa C.... Handa H. (J. Biol. Chem. 2002)
    9. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. (PubMed id 10369680)1, 3 GarcA-a E....Vidal M. (EMBO J. 1999)
    10. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PubMed id 12411495)1, 9 Schlisio S....Nevins J.R. (EMBO J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23429 HGNC: 10480 AceView: RYBP Ensembl:ENSG00000163602 euGenes: HUgn23429
    ECgene: RYBP H-InvDB: RYBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RYBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RYBP gene:
    Search GeneIP for patents involving RYBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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