RYBP Gene
protein-coding GIFtS: 55
GCID: GC03M072506
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|
RING1 and YY1 binding protein
| |
Aliases for RYBP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| RING1 And YY1 Binding Protein1 2 | | APAP-12 3 | | YEAF11 2 3 5 | | DED-Associated Factor2 3 | | DEDAF1 2 3 | | YY1 And E4TF1-Associated Factor 12 3 | | AAP11 2 | | RING1 And YY1-Binding Protein2 | | Apoptin-Associating Protein 12 3 | | Ring1 Interactor RYBP2 | | Death Effector Domain-Associated Factor2 3 | | YY1 And E4TF1 Associated Factor 12 |
Export aliases for RYBP gene to outside databasesPrevious GC identifers: GC03M070917 GC03M072035 GC03M072229 GC03M072344 |
Summaries for RYBP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulatingtranscription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of thetranscriptional activity of E4TF1. May bind to DNA. Promotes apoptosis Gene Wiki entry for RYBP
|
Genomic Views for RYBP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022459.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RYBP gene promoter: AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for RYBP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RYBP |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p13 Ensembl cytogenetic band: 3p13 HGNC cytogenetic band: 3p14.2RYBP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M072506: view genomic region
(about GC identifiers)
Start:
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72,423,744 bp from pter |
End:
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72,496,069 bp from pter |
Size:
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72,326 bases |
Orientation:
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minus strand |
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Proteins for RYBP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488 (See
protein sequence)Recommended Name: RING1 and YY1-binding protein Size: 228 amino acids; 24822 Da
Subunit: Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCORcomplex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together withGABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors.Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts withubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits ubiquitination of TP53.Identified in a ternary complex containing MDM2, TP53 and RYBP
Subcellular location: Nucleus. Cytoplasm. Nucleus, nucleoplasm (By similarity). Note=Primarily found in the nucleus.Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity)
Sequence caution: Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA89486.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for RYBP:3IXS (3D)
 
Secondary accessions: Q9P2W5 Q9UMW4Explore the universe of human proteins at neXtProt for RYBP: NX_Q8N488
Post-translational modifications:
Monoubiquitinated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N488 RYBP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036366.3 ENSEMBL proteins: ENSP00000419494 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RYBP for ontologies About GeneDecksing
RYBP Antibody Products: Assay Products for RYBP: |
Protein
Domains / Families for RYBP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RYBP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N488ProtoNet protein and cluster: Q8N488 1 Blocks protein family: IPB001876 Zn-finger
UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488Domain: Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (Bysimilarity)Similarity: Contains 1 RanBP2-type zinc finger |
Function for RYBP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulatingtranscription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of thetranscriptional activity of E4TF1. May bind to DNA. Promotes apoptosis
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RYBP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RYBP OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RYBP (NM_012234) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RYBP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RYBP  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RYBP for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rybp):
RYBP for phenotypes About GeneDecksing
|
Pathways & Interactions for RYBP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | E2F transcription factor network | | | 2 | Selected targets of Oct-3/4 | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for RYBP
1 BioSystems Pathway for RYBP 
RYBP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RYBP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/80 Interacting proteins for RYBP (Q8N4881, 2, 3 ENSP000004194944) via UniProtKB, MINT, STRING, and/or I2D (see all 80)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
RYBP for ontologies About GeneDecksing
|
Drugs & Compounds for RYBP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RYBP Search CenterWatch for drugs/clinical trials and news about RYBP 
|
Transcripts for RYBP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RYBP gene: NM_012234.5 Unigene Cluster for RYBP: RING1 and YY1 binding protein Hs.7910 [show with all ESTs]Unigene Representative Sequence: AB0295511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000477973(uc003dpe.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RYBP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RYBP OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RYBP (NM_012234) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RYBP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RYBP  |
Additional cDNA sequence: AB029551.1 AF085840.1 AF179286.1 AF227959.1 AL049940.1 AY228125.1 BC014959.1 BC036459.1 8 DOTS entries: DT.99968398 DT.455921 DT.100762428 DT.95153477 DT.120899217 DT.100787136 DT.100787133 DT.100787137 24/430 AceView cDNA sequences (see all 430): BG621024 AW590618 BM718962 AI652805 BM985193 AA399229 AI074551 BM981223 AI916580 N47290 BE866325 AI969760 AI253085 BU752384 AA353909 AW418638 BM994927 AI096521 BF446236 AW589651 AI422402 BQ946055 BE348891 Z42989 GeneLoc Exon Structure
|
Expression for RYBP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RYBP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CAGTTACAAA
About this image See RYBP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RYBP
SOURCE GeneReport for Unigene cluster: Hs.7910 UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488Tissue specificity: Widely expressed with highest levels in lymphoid tissues and placenta SABiosciences Expression via Pathway-Focused PCR Arrays including RYBP: | TGFB Signaling Targets in human mouse rat | | Polycomb & Trithorax Complexes in human mouse rat | | Polycomb & Trithorax Target Genes in human mouse rat |
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RYBP Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RYBP | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RYBP | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RYBP | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP |
Orthologs for RYBP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RYBP gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
RYBP1 |
RING1 and YY1 binding protein |
87.56(n) 96.77(a) |
  |
416095 XM_414428.3 XP_414428.3 |
lizard (Anolis carolinensis) |
Reptilia |
RYBP6 |
-- |
93(a) |
1 ↔ 1 |
2(179712837-179720103) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.78622 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_005739.1 (H.sapiens) YY1 associated factor 2 [Homo sapiens] less |
81.19(n) |
  |
BJ072372.1 |
zebrafish (Danio rerio) |
Actinopterygii |
rybp2 |
RING1 and YY1 binding protein |
79.24(n) |
  |
368248 BC054937.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
RYBP1 |
Ring and YY1 Binding Protein |
50(n) 49.33(a) |
  |
37601 NM_137861.2 NP_611705.1 |
ENSEMBL Gene Tree for RYBP (if available) TreeFam Gene Tree for RYBP (if available)  |
Paralogs for RYBP gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RYBP gene
- YAF22
1 SIMAP similar gene for RYBP using alignment to 2 protein entries: RYBP_HUMAN (see all proteins):YAF2
RYBP for paralogs About GeneDecksing
|
Genomic Variants for RYBP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RYBP (72423744 - 72496069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RYBP: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RYBP |
|
Disorders
/ Diseases for RYBP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RYBP for disorders About GeneDecksing
OMIM gene information: 607535
OMIM disorders: --
3 diseases for RYBP: About MalaCardsglycogen storage disease iv glycogen storage disease hodgkin's lymphoma
1 Novoseek disease relationship for RYBP gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hodgkin disease |
46.7 |
2 |
15470680 (1), 16528373 (1) |
Human Genome Epidemiology (HuGE) Navigator: RYBP (1 document) Export disorders for RYBP gene to outside databases
|
Publications for RYBP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RYBP gene, integrated from 9 sources (see all 34): (articles sorted by number of sources associating them with RYBP) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. (PubMed id 11395500)1, 2, 9 Zheng L.... Lenardo M.J. (2001)
- Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (2006)
- RYBP stabilizes p53 by modulating MDM2. (PubMed id 19098711)1, 2 Chen D....Zhang R. (2009)
- Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. (PubMed id 14765135)1, 2 Danen-van Oorschot A.A.M.M.... Noteborn M.H.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. (PubMed id 11953439)1, 2 Sawa C.... Handa H. (2002)
- RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. (PubMed id 10369680)1, 3 Garcia E....Vidal M. (1999)
- Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PubMed id 12411495)1, 9 Schlisio S....Nevins J.R. (2002)
- PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
- Polymorphisms in RYBP and AOAH genes are associated wi th chronic rhinosinusitis in a Chinese population: a replication study. (PubMed id 22723975)1 Zhang Y....Zhang L. (2012)
|
External Searches for RYBP gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RYBP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RYBP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RYBP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RYBP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RYBP gene: Search GeneIP for patents involving RYBP
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RYBP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP |
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