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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RYBP Gene

protein-coding   GIFtS: 55
GCID: GC03M072506

RING1 and YY1 binding protein

 Explore 3 diseases affiliated with
RYBP via our new
 Human Malady Compendium 
Biological research products
for RYBP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RING1 And YY1 Binding Protein1 2     APAP-12 3
YEAF11 2 3 5     DED-Associated Factor2 3
DEDAF1 2 3     YY1 And E4TF1-Associated Factor 12 3
AAP11 2     RING1 And YY1-Binding Protein2
Apoptin-Associating Protein 12 3     Ring1 Interactor RYBP2
Death Effector Domain-Associated Factor2 3     YY1 And E4TF1 Associated Factor 12

External Ids:    HGNC: 104801   Entrez Gene: 234292   Ensembl: ENSG000001636027   OMIM: 6075355   UniProtKB: Q8N4883   

Export aliases for RYBP gene to outside databases

Previous GC identifers: GC03M070917 GC03M072035 GC03M072229 GC03M072344


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating
transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the
transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis

Gene Wiki entry for RYBP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022459.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RYBP gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RYBP promoter sequence
   Search SABiosciences Chromatin IP Primers for RYBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RYBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p13   Ensembl cytogenetic band:  3p13   HGNC cytogenetic band: 3p14.2

RYBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RYBP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M072506:  view genomic region     (about GC identifiers)

Start:
72,423,744 bp from pter      End:
72,496,069 bp from pter
Size:
72,326 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488 (See protein sequence)
Recommended Name: RING1 and YY1-binding protein  
Size: 228 amino acids; 24822 Da
Subunit: Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR
complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together with
GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors.
Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with
ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits ubiquitination of TP53.
Identified in a ternary complex containing MDM2, TP53 and RYBP
Subcellular location: Nucleus. Cytoplasm. Nucleus, nucleoplasm (By similarity). Note=Primarily found in the nucleus.
Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity)
Sequence caution: Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA89486.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for RYBP:
3IXS (3D)    
Secondary accessions: Q9P2W5 Q9UMW4

Explore the universe of human proteins at neXtProt for RYBP: NX_Q8N488

Post-translational modifications:

  • Monoubiquitinated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N488

  • RYBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036366.3  
    ENSEMBL proteins: 
     ENSP00000419494  

    Human Recombinant Protein Products: 
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    Uscn Proteins for RYBP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IEA--
    GO:0031519colocalizes with PcG protein complex IDA16943429


    RYBP for ontologies           About GeneDecksing



    RYBP Antibody Products: 
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    ThermoFisher Antibodies for RYBP

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RYBP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8N488

    ProtoNet protein and cluster: Q8N488

    1 Blocks protein family: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Domain: Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By
    similarity)
    Similarity: Contains 1 RanBP2-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating
    transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the
    transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis

    miRNA
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    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate RYBP (see all 139):
    hsa-miR-411* hsa-miR-376b hsa-miR-106a hsa-miR-517a hsa-miR-4305 hsa-miR-128 hsa-miR-3074-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidRYBP 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI16943429
    GO:0008270zinc ion binding IEA--


    RYBP for ontologies           About GeneDecksing


    Animal Models:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rybp):
     embryogenesis  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system  vision/eye 

    RYBP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1E2F transcription factor network
    E2F transcription factor network1.00
    2Selected targets of Oct-3/4
    Selected targets of Oct-3/41.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RYBP
        Selected targets of Oct-3/4


    1 BioSystems Pathway for RYBP 
        E2F transcription factor network



    RYBP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RYBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for RYBP (Q8N4881, 2, 3 ENSP000004194944) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-7013717 MINT-7013897 MINT-7013883 MINT-7013688 MINT-7013847 MINT-7013745 MINT-7013780 MINT-7013760 MINT-7013730 MINT-7013864 MINT-7013672 I2D: score=2 STRING: ENSP00000417281
    HIST1H2AMP0C0S82, 3, ENSP000003526274MINT-3973842 MINT-3973898 I2D: score=1 STRING: ENSP00000352627
    HIST1H2AGP0C0S82, 3MINT-3973842 MINT-3973898 I2D: score=1 
    HIST1H2AIP0C0S82, 3MINT-3973842 MINT-3973898 I2D: score=1 
    HIST1H2AKP0C0S82, 3MINT-3973842 MINT-3973898 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0007275multicellular organismal development TAS10369680
    GO:0035518histone H2A monoubiquitination IDA16943429


    RYBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RYBP
    Search CenterWatch for drugs/clinical trials and news about RYBP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RYBP gene: 
    NM_012234.5  

    Unigene Cluster for RYBP:

    RING1 and YY1 binding protein
    Hs.7910  [show with all ESTs]
    Unigene Representative Sequence: AB029551
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000477973(uc003dpe.3)

    miRNA
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    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate RYBP (see all 139):
    hsa-miR-411* hsa-miR-376b hsa-miR-106a hsa-miR-517a hsa-miR-4305 hsa-miR-128 hsa-miR-3074-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidRYBP 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RYBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RYBP

    Additional cDNA sequence: 

    AB029551.1 AF085840.1 AF179286.1 AF227959.1 AL049940.1 AY228125.1 BC014959.1 BC036459.1 

    8 DOTS entries:

    DT.99968398  DT.455921  DT.100762428  DT.95153477  DT.120899217  DT.100787136  DT.100787133  DT.100787137 

    24/430 AceView cDNA sequences (see all 430):

    BG621024 AW590618 BM718962 AI652805 BM985193 AA399229 AI074551 BM981223 
    AI916580 N47290 BE866325 AI969760 AI253085 BU752384 AA353909 AW418638 
    BM994927 AI096521 BF446236 AW589651 AI422402 BQ946055 BE348891 Z42989 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RYBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTTACAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RYBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RYBP

    SOURCE GeneReport for Unigene cluster: Hs.7910

    UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Tissue specificity: Widely expressed with highest levels in lymphoid tissues and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including RYBP: 
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              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RYBP gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RYBP1 RING1 and YY1 binding protein 87.56(n)
    96.77(a)
      416095  XM_414428.3  XP_414428.3 
    lizard
    (Anolis carolinensis)
    Reptilia RYBP6
    --
    93(a)
    1 ↔ 1
    2(179712837-179720103)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.78622 Xenopus laevis transcribed sequence with weak similarity more 81.19(n)    BJ072372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rybp2 RING1 and YY1 binding protein 79.24(n)   368248  BC054937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RYBP1 Ring and YY1 Binding Protein 50(n)
    49.33(a)
      37601  NM_137861.2  NP_611705.1 


    ENSEMBL Gene Tree for RYBP (if available)
    TreeFam Gene Tree for RYBP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RYBP gene
    YAF22  
    1 SIMAP similar gene for RYBP using alignment to 2 protein entries:     RYBP_HUMAN (see all proteins):
    YAF2

    RYBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1268 NCBI SNPs in RYBP are shown (see all 1268    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378864021,2
    --72423321(+) TAAGTC/GAGCTT 1 -- int10--------
    rs1494503301,2
    --72423441(+) ATTAGC/TATATT 1 -- int10--------
    rs1832804051,2
    --72423442(+) TTAGCA/GTATTT 1 -- int10--------
    rs1879215341,2
    --72423499(+) ACATCA/TTTGCA 1 -- int10--------
    rs1923066611,2
    --72423509(+) AATCTA/CTCTCA 1 -- int10--------
    rs1430874681,2
    --72423702(+) AAAATC/TAACTA 1 -- int10--------
    rs1829625851,2
    --72423745(+) AATAAA/CGATTT 1 -- ut310--------
    rs1878452791,2
    --72423968(+) TTTGAC/TCAGTT 1 -- ut310--------
    rs1929550631,2
    --72424059(+) AGAAAA/CTTCCA 1 -- ut310--------
    rs1843541051,2
    --72424282(+) AAAACC/TGTTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RYBP (72423744 - 72496069 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RYBP: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RYBP for disorders           About GeneDecksing

    OMIM gene information: 607535    OMIM disorders: --

    3 diseases for RYBP:    About MalaCards
    glycogen storage disease iv    glycogen storage disease    hodgkin's lymphoma

    1 Novoseek disease relationship for RYBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 46.7 2 15470680 (1), 16528373 (1)

    Human Genome Epidemiology (HuGE) Navigator: RYBP (1 document)

    Export disorders for RYBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RYBP gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RYBP)
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    1. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. (PubMed id 11395500)1, 2, 9 Zheng L.... Lenardo M.J. (2001)
    2. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (2006)
    3. RYBP stabilizes p53 by modulating MDM2. (PubMed id 19098711)1, 2 Chen D....Zhang R. (2009)
    4. Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. (PubMed id 14765135)1, 2 Danen-van Oorschot A.A.M.M.... Noteborn M.H.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. (PubMed id 11953439)1, 2 Sawa C.... Handa H. (2002)
    7. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. (PubMed id 10369680)1, 3 Garcia E....Vidal M. (1999)
    8. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PubMed id 12411495)1, 9 Schlisio S....Nevins J.R. (2002)
    9. PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
    10. Polymorphisms in RYBP and AOAH genes are associated wi th chronic rhinosinusitis in a Chinese population: a replication study. (PubMed id 22723975)1 Zhang Y....Zhang L. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23429 HGNC: 10480 AceView: RYBP Ensembl:ENSG00000163602 euGenes: HUgn23429
    ECgene: RYBP H-InvDB: RYBP

    (According to HUGE)
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