Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RYBP Gene

protein-coding   GIFtS: 58
GCID: GC03M072506

RING1 And YY1 Binding Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RING1 And YY1 Binding Protein1 2     APAP-12 3
Apoptin-Associating Protein 11 2 3     DEDAF2 3
Death Effector Domain-Associated Factor1 2 3     DED-Associated Factor2 3
YEAF12 3 5     YY1 And E4TF1-Associated Factor 12 3
Ring1 Interactor RYBP1 2     AAP12
YY1 And E4TF1 Associated Factor 11 2     RING1 And YY1-Binding Protein2

External Ids:    HGNC: 104801   Entrez Gene: 234292   Ensembl: ENSG000001636027   OMIM: 6075355   UniProtKB: Q8N4883   

Export aliases for RYBP gene to outside databases

Previous GC identifers: GC03M070917 GC03M072035 GC03M072229 GC03M072344


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RYBP Gene: 
RYBP (RING1 and YY1 binding protein) is a protein-coding gene. Diseases associated with RYBP include glycogen storage disease iv, and glycogen storage disease. GO annotations related to this gene include DNA binding and transcription corepressor activity. An important paralog of this gene is YAF2.

UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating
transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of
the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis

Gene Wiki entry for RYBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022459.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RYBP gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RYBP promoter sequence
   Search SABiosciences Chromatin IP Primers for RYBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RYBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p13   Ensembl cytogenetic band:  3p13   HGNC cytogenetic band: 3p14.2

RYBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RYBP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M072506:  view genomic region     (about GC identifiers)

Start:
72,423,744 bp from pter      End:
72,496,069 bp from pter
Size:
72,326 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488 (See protein sequence)
Recommended Name: RING1 and YY1-binding protein  
Size: 228 amino acids; 24822 Da
Subunit: Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR
complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together
with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription
factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins.
Interacts with ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits
ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP
Subcellular location: Nucleus. Cytoplasm. Nucleus, nucleoplasm (By similarity). Note=Primarily found in the
nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity)
Sequence caution: Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA89486.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for RYBP:
3IXS (3D)    
Secondary accessions: Q9P2W5 Q9UMW4

Explore the universe of human proteins at neXtProt for RYBP: NX_Q8N488

Explore proteomics data for RYBP at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N488

  • RYBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RYBP Protein Expression
    REFSEQ proteins: NP_036366.3  
    ENSEMBL proteins: 
     ENSP00000419494  

    Human Recombinant Protein Products for RYBP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RYBP
    OriGene Protein Over-expression Lysate for RYBP
    OriGene MassSpec for RYBP 
    OriGene Custom Protein Services for RYBP
    GenScript Custom Purified and Recombinant Proteins Services for RYBP
    Novus Biologicals RYBP Proteins
    Novus Biologicals RYBP Lysates
    Sino Biological Recombinant Protein for RYBP
    Sino Biological Cell Lysate for RYBP 
    ProSpec Recombinant Protein for RYBP
    Cloud-Clone Corp. Proteins for RYBP 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IEA--
    GO:0031519colocalizes with PcG protein complex IDA16943429

    RYBP for ontologies           About GeneDecksing



    RYBP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RYBP
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RYBP
    OriGene Custom Antibody Services for RYBP
    GenScript Custom Superior Antibodies Services for RYBP
    Novus Biologicals RYBP Antibodies
    Abcam antibodies for RYBP
    Cloud-Clone Corp. Antibodies for RYBP 
    ThermoFisher Antibodies for RYBP
    LSBio Antibodies in human, mouse, rat for RYBP 

    Assay Products for RYBP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RYBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RYBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RYBP 
    Cloud-Clone Corp. CLIAs for RYBP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8N488

    ProtoNet protein and cluster: Q8N488

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Domain: Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By
    similarity)
    Similarity: Contains 1 RanBP2-type zinc finger


    RYBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RYBP_HUMAN, Q8N488
    Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating
    transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of
    the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
         
    RYBP for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rybp):
     embryogenesis  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system  vision/eye 

    RYBP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RYBP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RYBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RYBP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RYBP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RYBP
    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate RYBP (see all 139):
    hsa-miR-411* hsa-miR-376b hsa-miR-106a hsa-miR-517a hsa-miR-4305 hsa-miR-128 hsa-miR-3074-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidRYBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RYBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RYBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RYBP
    Sirion Biotech Customized adenovirus for overexpression of RYBP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RYBP (see all 7)
    OriGene ORF clones in mouse, rat for RYBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RYBP (NM_012234)
    Sino Biological Human cDNA Clone for RYBP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RYBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RYBP
    Sirion Biotech Customized lentivirus for stable overexpression of RYBP 
                         Customized lentivirus expression plasmids for stable overexpression of RYBP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RYBP
    Search LifeMap BioReagents cell lines for RYBP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RYBP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1E2F transcription factor network
    E2F transcription factor network
    2Selected targets of Oct-3/4
    Selected targets of Oct-3/4

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RYBP
        Selected targets of Oct-3/4


    1 BioSystems Pathway for RYBP
        E2F transcription factor network




    RYBP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RYBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for RYBP (Q8N4881, 2, 3 ENSP000004194944) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 STRING: ENSP00000396439
    MDM2Q009872, 3, ENSP000004172814MINT-7013717 MINT-7013897 MINT-7013883 MINT-7013688 MINT-7013847 MINT-7013745 MINT-7013780 MINT-7013760 MINT-7013730 MINT-7013864 MINT-7013672 I2D: score=2 STRING: ENSP00000417281
    RING1Q065871, 2, 3, ENSP000003637874EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 STRING: ENSP00000363787
    ENSG00000206287Q065871, 2, 3EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 
    ENSG00000226788Q065871, 2, 3EBI-752324,EBI-752313 MINT-8010325 MINT-68437 I2D: score=8 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0007275multicellular organismal development TAS10369680
    GO:0035518histone H2A monoubiquitination IDA16943429

    RYBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RYBP

    Search CenterWatch for drugs/clinical trials and news about RYBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RYBP gene: 
    NM_012234.5  

    Unigene Cluster for RYBP:

    RING1 and YY1 binding protein
    Hs.7910  [show with all ESTs]
    Unigene Representative Sequence: AB029551
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000477973(uc003dpe.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RYBP
    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate RYBP (see all 139):
    hsa-miR-411* hsa-miR-376b hsa-miR-106a hsa-miR-517a hsa-miR-4305 hsa-miR-128 hsa-miR-3074-3p hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidRYBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RYBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RYBP
    Clone
    Products:
         
    OriGene clones in human, mouse for RYBP (see all 7)
    OriGene ORF clones in mouse, rat for RYBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RYBP (NM_012234)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RYBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RYBP
    Sirion Biotech Customized lentivirus for stable overexpression of RYBP 
                         Customized lentivirus expression plasmids for stable overexpression of RYBP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RYBP
    OriGene qSTAR qPCR primer pairs in human, mouse for RYBP
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RYBP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RYBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RYBP

    Additional mRNA sequence: 

    AB029551.1 AF085840.1 AF179286.1 AF227959.1 AL049940.1 AY228125.1 BC014959.1 BC036459.1 

    8 DOTS entries:

    DT.99968398  DT.455921  DT.100762428  DT.95153477  DT.120899217  DT.100787136  DT.100787133  DT.100787137 

    24/430 AceView cDNA sequences (see all 430):

    BM142476 BG621024 BM668034 BM981223 AW590618 AI824418 BU629102 AA688047 
    BE348891 CA311502 BQ015219 AA399229 BM985193 BF436182 BU752384 AI969760 
    BE467424 AI074551 AW590747 AI146559 AI831906 AA811691 T32793 AI652805 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RYBP expression in normal human tissues (normalized intensities)      RYBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTACAAA
    RYBP Expression
    About this image


    RYBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             cd31+ cells   
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Endothelium (Cardiovascular System)
             cd31+ cells   

    See RYBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RYBP

    SOURCE GeneReport for Unigene cluster: Hs.7910

    UniProtKB/Swiss-Prot: RYBP_HUMAN, Q8N488
    Tissue specificity: Widely expressed with highest levels in lymphoid tissues and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including RYBP: 
              TGFB Signaling Targets in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RYBP
    OriGene qSTAR qPCR primer pairs in human, mouse for RYBP
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RYBP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RYBP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RYBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RYBP gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rybp1 , 5 RING1 and YY1 binding protein1, 5 93.71(n)1
    99.12(a)1
      6 (46.62 cM)5
    563531  NM_019743.31  NP_062717.21 
     1002285655 
    chicken
    (Gallus gallus)
    Aves RYBP1 RING1 and YY1 binding protein 87.56(n)
    96.77(a)
      416095  XM_414428.3  XP_414428.3 
    lizard
    (Anolis carolinensis)
    Reptilia RYBP6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    2(179654002-179720103)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.78622 Xenopus laevis transcribed sequence with weak similarity more 81.19(n)    BJ072372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rybp2 RING1 and YY1 binding protein 79.24(n)   368248  BC054937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RYBP1 Ring and YY1 Binding Protein 50(n)
    49.33(a)
      37601  NM_137861.2  NP_611705.1 


    ENSEMBL Gene Tree for RYBP (if available)
    TreeFam Gene Tree for RYBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RYBP gene
    YAF22  
    1 SIMAP similar gene for RYBP using alignment to 2 protein entries:     RYBP_HUMAN (see all proteins):
    YAF2

    RYBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1496 SNPs in RYBP are shown (see all 1496)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378864021,2
    --72423321(+) TAAGTC/GAGCTT 1 -- int10--------
    rs1494503301,2
    --72423441(+) ATTAGC/TATATT 1 -- int10--------
    rs1832804051,2
    --72423442(+) TTAGCA/GTATTT 1 -- int10--------
    rs1879215341,2
    --72423499(+) ACATCA/TTTGCA 1 -- int10--------
    rs1923066611,2
    --72423509(+) AATCTA/CTCTCA 1 -- int10--------
    rs1430874681,2
    --72423702(+) AAAATC/TAACTA 1 -- int10--------
    rs1829625851,2
    --72423745(+) AATAAA/CGATTT 1 -- ut310--------
    rs1878452791,2
    --72423968(+) TTTGAC/TCAGTT 1 -- ut310--------
    rs1929550631,2
    --72424059(+) AGAAAA/CTTCCA 1 -- ut310--------
    rs1843541051,2
    --72424282(+) AAAACC/TGTTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RYBP (72423744 - 72496069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RYBP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1338763CNV Deletion17803354
    esv990953CNV Deletion20482838
    esv267750CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RYBP
    DNA2.0 Custom Variant and Variant Library Synthesis for RYBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607535    OMIM disorders: --

    3 diseases for RYBP:    About MalaCards
    glycogen storage disease iv    glycogen storage disease    hodgkin's lymphoma


    RYBP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RYBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 46.7 2 15470680 (1), 16528373 (1)

    Genetic Association Database (GAD): RYBP
    Human Genome Epidemiology (HuGE) Navigator: RYBP (1 document)

    Export disorders for RYBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RYBP gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with RYBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. (PubMed id 11395500)1, 2, 9 Zheng L.... Lenardo M.J. (2001)
    2. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    5. RYBP stabilizes p53 by modulating MDM2. (PubMed id 19098711)1, 2 Chen D....Zhang R. (2009)
    6. Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. (PubMed id 14765135)1, 2 Danen-van Oorschot A.A.M.M.... Noteborn M.H.M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. (PubMed id 11953439)1, 2 Sawa C.... Handa H. (2002)
    9. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. (PubMed id 10369680)1, 3 Garcia E....Vidal M. (1999)
    10. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PubMed id 12411495)1, 9 Schlisio S....Nevins J.R. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23429 HGNC: 10480 AceView: RYBP Ensembl:ENSG00000163602 euGenes: HUgn23429
    ECgene: RYBP H-InvDB: RYBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RYBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RYBP gene:
    Search GeneIP for patents involving RYBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RYBP
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RYBP   OriGene RNAi products in human, mouse, rat for RYBP  
     OriGene qPCR primer pairs and template standards for RYBP   OriGene Protein Over-expression Lysate for RYBP  
     OriGene MassSpec something-or-other for RYBP   OriGene clones in human, mouse for RYBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for RYBP   OriGene Purified Protein for RYBP  
     OriGene ORF clones in mouse, rat for RYBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RYBP   OriGene Custom Protein Services for RYBP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RYBP
     QIAGEN SeqTarget long-range PCR primers for resequencing RYBP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RYBP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RYBP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RYBP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RYBP
     GenScript Custom Purified and Recombinant Proteins Services for RYBP GenScript cDNA clones with any tag delivered in your preferred vector for RYBP
     GenScript Custom Assay Services for RYBP GenScript Custom Superior Antibodies Services for RYBP
     GenScript Custom overexpressing Cell Line Services for RYBP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RYBP promoter
     Search Chromatin IP Primers for RYBP
     RT2 qPCR Primer Assay in human, mouse / rat RYBP
     GNC Network for RYBP
     SABiosciences PCR Arrays including human, mouse / rat RYBP
     Search Tocris compounds for RYBP
     Proteins and Antibodies for RYBP
     Cell Lysates for RYBP
     cDNA Clones for RYBP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RYBP antibodies
     RYBP proteins
     RYBP lysates
     Antibodies for RYBP
     See all of Abcam's Antibodies, Kits and Proteins for RYBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RYBP




     Proteins for RYBP
     Antibodies for RYBP
     ELISAs for RYBP
     CLIAs for RYBP
     Search LifeMap BioReagents cell lines for RYBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RYBP
     SwitchGear 3'UTR luciferase reporter plasmids for RYBP
     SwitchGear Promoter luciferase reporter plasmids for RYBP
     ThermoFisher Antibodies for RYBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RYBP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RYBP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RYBP
    Customized:
     lentivirus for stable overexpression of RYBP
     lentivirus expression plasmids for stable overexpression of RYBP
     adenovirus for overexpression of RYBP
     LSBio Antibodies in human, mouse, rat for RYBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RYBP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4