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Aliases for RYBP Gene

Aliases for RYBP Gene

  • RING1 And YY1 Binding Protein 2 3
  • Death Effector Domain-Associated Factor 2 3 4
  • Apoptin-Associating Protein 1 2 3 4
  • YEAF1 3 4 6
  • YY1 And E4TF1 Associated Factor 1 2 3
  • YY1 And E4TF1-Associated Factor 1 3 4
  • Ring1 Interactor RYBP 2 3
  • DED-Associated Factor 3 4
  • APAP-1 3 4
  • DEDAF 3 4
  • RING1 And YY1-Binding Protein 3
  • AAP1 3

External Ids for RYBP Gene

Previous GeneCards Identifiers for RYBP Gene

  • GC03M070917
  • GC03M072035
  • GC03M072229
  • GC03M072344
  • GC03M072506

Summaries for RYBP Gene

GeneCards Summary for RYBP Gene

RYBP (RING1 And YY1 Binding Protein) is a Protein Coding gene. Among its related pathways are E2F transcription factor network. GO annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot for RYBP Gene

  • Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.

Gene Wiki entry for RYBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RYBP Gene

Genomics for RYBP Gene

Genomic Location for RYBP Gene

Start:
72,371,825 bp from pter
End:
72,446,918 bp from pter
Size:
75,094 bases
Orientation:
Minus strand

Genomic View for RYBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RYBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RYBP Gene

Proteins for RYBP Gene

  • Protein details for RYBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N488-RYBP_HUMAN
    Recommended name:
    RING1 and YY1-binding protein
    Protein Accession:
    Q8N488
    Secondary Accessions:
    • Q9P2W5
    • Q9UMW4

    Protein attributes for RYBP Gene

    Size:
    228 amino acids
    Molecular mass:
    24822 Da
    Quaternary structure:
    • Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP.
    SequenceCaution:
    • Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA89486.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RYBP Gene

neXtProt entry for RYBP Gene

Proteomics data for RYBP Gene at MOPED

Post-translational modifications for RYBP Gene

Other Protein References for RYBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RYBP Gene

Domains for RYBP Gene

Protein Domains for RYBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RYBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N488

UniProtKB/Swiss-Prot:

RYBP_HUMAN :
  • Q8N488
Domain:
  • Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By similarity).
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with RYBP: view

No data available for Gene Families for RYBP Gene

Function for RYBP Gene

Molecular function for RYBP Gene

UniProtKB/Swiss-Prot Function: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.

Gene Ontology (GO) - Molecular Function for RYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RYBP: view
genes like me logo Genes that share phenotypes with RYBP: view

miRNA for RYBP Gene

miRTarBase miRNAs that target RYBP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RYBP Gene

Localization for RYBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RYBP Gene

Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RYBP Gene COMPARTMENTS Subcellular localization image for RYBP gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IEA --
GO:0031519 colocalizes_with PcG protein complex IDA 16943429
genes like me logo Genes that share ontologies with RYBP: view

Pathways for RYBP Gene

genes like me logo Genes that share pathways with RYBP: view

Pathways by source for RYBP Gene

1 BioSystems pathway for RYBP Gene

Gene Ontology (GO) - Biological Process for RYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organismal development TAS 10369680
GO:0035518 histone H2A monoubiquitination IDA 16943429
genes like me logo Genes that share ontologies with RYBP: view

Transcripts for RYBP Gene

mRNA/cDNA for RYBP Gene

Unigene Clusters for RYBP Gene

RING1 and YY1 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RYBP Gene

No ASD Table

Relevant External Links for RYBP Gene

GeneLoc Exon Structure for
RYBP
ECgene alternative splicing isoforms for
RYBP

Expression for RYBP Gene

mRNA expression in normal human tissues for RYBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RYBP Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RYBP Gene

SOURCE GeneReport for Unigene cluster for RYBP Gene Hs.7910

mRNA Expression by UniProt/SwissProt for RYBP Gene

Q8N488-RYBP_HUMAN
Tissue specificity: Widely expressed with highest levels in lymphoid tissues and placenta.
genes like me logo Genes that share expressions with RYBP: view

Orthologs for RYBP Gene

This gene was present in the common ancestor of animals.

Orthologs for RYBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RYBP 35
  • 99.85 (n)
  • 100 (a)
RYBP 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RYBP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RYBP 35
  • 97.25 (n)
  • 100 (a)
RYBP 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rybp 35
  • 93.71 (n)
  • 99.12 (a)
Rybp 16
Rybp 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RYBP 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RYBP 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves RYBP 35
  • 87.52 (n)
  • 96.35 (a)
RYBP 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RYBP 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7862 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12272 35
zebrafish
(Danio rerio)
Actinopterygii rybp 35
rybpa 36
  • 38 (a)
OneToMany
rybpb 35
  • 77.23 (n)
  • 82.59 (a)
rybpb 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RYBP 36
  • 51 (a)
OneToMany
Species with no ortholog for RYBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RYBP Gene

ENSEMBL:
Gene Tree for RYBP (if available)
TreeFam:
Gene Tree for RYBP (if available)

Paralogs for RYBP Gene

Selected SIMAP similar genes for RYBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RYBP: view

No data available for Paralogs for RYBP Gene

Variants for RYBP Gene

Sequence variations from dbSNP and Humsavar for RYBP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11286 -- 72,377,018(+) TTACA(G/T)GCTGC utr-variant-3-prime
rs12956 -- 72,375,320(-) GAAGC(C/T)TCTGT utr-variant-3-prime
rs13109 -- 72,377,029(+) TCGCA(C/G/T)TAAGT utr-variant-3-prime
rs13887 -- 72,377,220(-) AGAAT(A/C/G)CTCAC utr-variant-3-prime
rs753317 -- 72,397,923(+) ATTTT(A/G)AGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RYBP Gene

Variant ID Type Subtype PubMed ID
esv267750 CNV Insertion 20981092
esv990953 CNV Deletion 20482838
esv1338763 CNV Deletion 17803354

Relevant External Links for RYBP Gene

HapMap Linkage Disequilibrium report
RYBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RYBP Gene

Disorders for RYBP Gene

(1) Novoseek inferred disease relationships for RYBP Gene

Disease -log(P) Hits PubMed IDs
hodgkin disease 46.7 2

Relevant External Links for RYBP

Genetic Association Database (GAD)
RYBP
Human Genome Epidemiology (HuGE) Navigator
RYBP
genes like me logo Genes that share disorders with RYBP: view

No data available for UniProtKB/Swiss-Prot for RYBP Gene

Publications for RYBP Gene

  1. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. (PMID: 11395500) Zheng L. … Lenardo M.J. (J. Biol. Chem. 2001) 3 4 23
  2. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PMID: 16943429) Gearhart M.D. … Bardwell V.J. (Mol. Cell. Biol. 2006) 3 4 23
  3. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. (PMID: 10369680) GarcA-a E. … Vidal M. (EMBO J. 1999) 2 3
  4. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PMID: 12411495) Schlisio S. … Nevins J.R. (EMBO J. 2002) 3 23
  5. Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. (PMID: 14765135) Danen-van Oorschot A.A.M.M. … Noteborn M.H.M. (Cell Death Differ. 2004) 3 4

Products for RYBP Gene

Sources for RYBP Gene

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