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Aliases for RYBP Gene

Aliases for RYBP Gene

  • RING1 And YY1 Binding Protein 2 3 5
  • Death Effector Domain-Associated Factor 2 3 4
  • Apoptin-Associating Protein 1 2 3 4
  • YY1 And E4TF1 Associated Factor 1 2 3
  • Ring1 Interactor RYBP 2 3
  • DED-Associated Factor 3 4
  • APAP-1 3 4
  • DEDAF 3 4
  • YEAF1 3 4
  • YY1 And E4TF1-Associated Factor 1 4
  • RING1 And YY1-Binding Protein 3
  • AAP1 3

External Ids for RYBP Gene

Previous GeneCards Identifiers for RYBP Gene

  • GC03M070917
  • GC03M072035
  • GC03M072229
  • GC03M072344
  • GC03M072506

Summaries for RYBP Gene

GeneCards Summary for RYBP Gene

RYBP (RING1 And YY1 Binding Protein) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Chromatin Regulation / Acetylation. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is YAF2.

UniProtKB/Swiss-Prot for RYBP Gene

  • Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.

Gene Wiki entry for RYBP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RYBP Gene

Genomics for RYBP Gene

Regulatory Elements for RYBP Gene

Enhancers for RYBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G072076 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.6 +366.4 366425 6.9 HDGF PKNOX1 FOXA2 ATF1 FEZF1 YBX1 YY1 TCF12 ZNF766 ELK1 RYBP PROK2 GPR27 EIF4E3 LINC00877 FOXP1 ENSG00000276471 ENSG00000273461
GH03G072445 1.3 ENCODE dbSUPER 29.8 -0.8 -794 4.0 PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF143 RYBP LOC105377160
GH03G072375 1.8 ENCODE dbSUPER 21.2 +71.0 70963 0.8 OSR2 GATA2 JUNB MLLT1 RYBP PIR53049 ENSG00000260670
GH03G072268 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +176.4 176405 3.6 PKNOX1 YY1 ZNF766 FOS ZHX2 JUNB ZNF592 KAT8 MEF2D MIER3 RYBP LINC00877 ENSG00000242618
GH03G072482 1.5 FANTOM5 Ensembl ENCODE 22.5 -36.5 -36480 1.2 HDAC1 NFRKB FEZF1 RAD21 RARA RFX5 YY1 GLIS2 EGR1 FOS RYBP SHQ1 RNU1-62P GC03P072480 ENSG00000244345
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RYBP on UCSC Golden Path with GeneCards custom track

Promoters for RYBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000154498 323 2601 PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 ZNF766 ELK1 ZNF143 ZNF207

Genomic Location for RYBP Gene

Chromosome:
3
Start:
72,371,825 bp from pter
End:
72,446,623 bp from pter
Size:
74,799 bases
Orientation:
Minus strand

Genomic View for RYBP Gene

Genes around RYBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RYBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RYBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RYBP Gene

Proteins for RYBP Gene

  • Protein details for RYBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N488-RYBP_HUMAN
    Recommended name:
    RING1 and YY1-binding protein
    Protein Accession:
    Q8N488
    Secondary Accessions:
    • Q9P2W5
    • Q9UMW4

    Protein attributes for RYBP Gene

    Size:
    228 amino acids
    Molecular mass:
    24822 Da
    Quaternary structure:
    • Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP. Interacts with PCGF1 (PubMed:26687479).
    SequenceCaution:
    • Sequence=AAK63197.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO73587.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA89486.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RYBP Gene

neXtProt entry for RYBP Gene

Post-translational modifications for RYBP Gene

Other Protein References for RYBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RYBP (RYBP)
  • Abcam antibodies for RYBP

No data available for DME Specific Peptides for RYBP Gene

Domains & Families for RYBP Gene

Gene Families for RYBP Gene

Protein Domains for RYBP Gene

Suggested Antigen Peptide Sequences for RYBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N488

UniProtKB/Swiss-Prot:

RYBP_HUMAN :
  • Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By similarity).
Domain:
  • Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By similarity).
genes like me logo Genes that share domains with RYBP: view

Function for RYBP Gene

Molecular function for RYBP Gene

UniProtKB/Swiss-Prot Function:
Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.

Gene Ontology (GO) - Molecular Function for RYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RYBP: view
genes like me logo Genes that share phenotypes with RYBP: view

Animal Model Products

CRISPR Products

miRNA for RYBP Gene

miRTarBase miRNAs that target RYBP

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RYBP Gene

Localization for RYBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RYBP Gene

Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RYBP gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0031519 colocalizes_with PcG protein complex IDA 16943429
genes like me logo Genes that share ontologies with RYBP: view

Pathways & Interactions for RYBP Gene

genes like me logo Genes that share pathways with RYBP: view

Pathways by source for RYBP Gene

1 Cell Signaling Technology pathway for RYBP Gene
1 BioSystems pathway for RYBP Gene

SIGNOR curated interactions for RYBP Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development TAS 10369680
genes like me logo Genes that share ontologies with RYBP: view

Drugs & Compounds for RYBP Gene

No Compound Related Data Available

Transcripts for RYBP Gene

mRNA/cDNA for RYBP Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(430) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RYBP Gene

RING1 and YY1 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RYBP Gene

No ASD Table

Relevant External Links for RYBP Gene

GeneLoc Exon Structure for
RYBP
ECgene alternative splicing isoforms for
RYBP

Expression for RYBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RYBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RYBP Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for RYBP Gene

This gene is overexpressed in Testis (12.6), Peripheral blood mononuclear cells (12.5), Blymphocyte (7.0), Fetal testis (6.2), and Retina (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RYBP Gene



Protein tissue co-expression partners for RYBP Gene

NURSA nuclear receptor signaling pathways regulating expression of RYBP Gene:

RYBP

SOURCE GeneReport for Unigene cluster for RYBP Gene:

Hs.7910

mRNA Expression by UniProt/SwissProt for RYBP Gene:

Q8N488-RYBP_HUMAN
Tissue specificity: Widely expressed with highest levels in lymphoid tissues and placenta.

Evidence on tissue expression from TISSUES for RYBP Gene

  • Nervous system(4.7)
  • Muscle(4.1)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with RYBP: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RYBP Gene

Orthologs for RYBP Gene

This gene was present in the common ancestor of animals.

Orthologs for RYBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RYBP 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia RYBP 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RYBP 34 35
  • 97.25 (n)
mouse
(Mus musculus)
Mammalia Rybp 34 35
  • 93.71 (n)
Rybp-ps 16
platypus
(Ornithorhynchus anatinus)
Mammalia RYBP 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RYBP 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RYBP 34 35
  • 87.52 (n)
lizard
(Anolis carolinensis)
Reptilia RYBP 35
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7862 34
zebrafish
(Danio rerio)
Actinopterygii rybpb 34 35
  • 77.23 (n)
rybpa 35
  • 38 (a)
OneToMany
rybp 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12272 34
fruit fly
(Drosophila melanogaster)
Insecta RYBP 35
  • 51 (a)
OneToMany
Species where no ortholog for RYBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RYBP Gene

ENSEMBL:
Gene Tree for RYBP (if available)
TreeFam:
Gene Tree for RYBP (if available)

Paralogs for RYBP Gene

Paralogs for RYBP Gene

(1) SIMAP similar genes for RYBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RYBP: view

Variants for RYBP Gene

Sequence variations from dbSNP and Humsavar for RYBP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000008590 -- 72,438,495(+) TTGAA(A/T)AAACA intron-variant
rs1000046401 -- 72,394,988(+) CACCA(A/G)AAGTT intron-variant
rs1000094419 -- 72,448,680(+) AAGGG(C/T)CGTAG upstream-variant-2KB
rs1000146249 -- 72,410,939(+) GATGG(A/G)TATAA intron-variant
rs1000165018 -- 72,434,031(+) TTTAA(A/T)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RYBP Gene

Variant ID Type Subtype PubMed ID
esv1338763 CNV deletion 17803354
esv3303471 CNV mobile element insertion 20981092
esv3325196 CNV insertion 20981092
esv990953 CNV deletion 20482838
nsv954886 CNV duplication 24416366

Relevant External Links for RYBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RYBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RYBP Gene

Disorders for RYBP Gene

Relevant External Links for RYBP

Genetic Association Database (GAD)
RYBP
Human Genome Epidemiology (HuGE) Navigator
RYBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RYBP

No disorders were found for RYBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RYBP Gene

Publications for RYBP Gene

  1. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PMID: 16943429) Gearhart M.D. … Bardwell V.J. (Mol. Cell. Biol. 2006) 3 4 22 64
  2. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. (PMID: 11395500) Zheng L. … Lenardo M.J. (J. Biol. Chem. 2001) 3 4 22 64
  3. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64

Products for RYBP Gene

Sources for RYBP Gene

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