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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RXRG Gene

protein-coding   GIFtS: 66
GCID: GC01M165370

retinoid X receptor, gamma
 Explore 27 diseases affiliated with
RXRG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RXRG    

Aliases
for RXRG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Retinoid X Receptor, Gamma1 2
NR2B31 2 3
Nuclear Receptor Subfamily 2 Group B Member 32 3
RXRC2
Retinoic Acid Receptor RXR-Gamma2
Retinoid X Receptor Gamma3

External Ids:    HGNC: 104791   Entrez Gene: 62582   Ensembl: ENSG000001431717   OMIM: 1802475   UniProtKB: P484433   

Export aliases for RXRG gene to outside databases

Previous GC identifers: GC01M163005 GC01M161021 GC01M162066 GC01M162557 GC01M162102 GC01M163636 GC01M136616


Summaries
for RXRG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RXRG:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating
the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid
hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective
response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells.
Alternatively spliced transcript variants have been described. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in
response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological
processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3'
sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)

summary for RXRG:
Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding
partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors
(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding
efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully
elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR
signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major
isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely
distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.

Gene Wiki entry for RXRG (Retinoid X receptor gamma)


Genomic Views
for RXRG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RXRG gene promoter:
         Egr-3   STAT1   HSF2   IRF-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RXRG promoter sequence
   Search SABiosciences Chromatin IP Primers for RXRG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RXRG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22-q23

RXRG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXRG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M165370:  view genomic region     (about GC identifiers)

Start:
 165,370,159 bp from pter      End:
 165,414,592 bp from pter
Size:
 44,434 bases      Orientation:
 minus strand

Proteins
for RXRG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443 (See protein sequence)
Recommended Name: Retinoic acid receptor RXR-gamma  
Size: 463 amino acids; 50871 Da
Subunit: Homodimer (By similarity). Heterodimer with a RAR molecule (By similarity). Binds DNA preferentially as a
RAR/RXR heterodimer (By similarity)
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for RXRG:
2GL8 (3D)    
Secondary accessions: A6NIP1 Q6IBU7

Explore the universe of human proteins at neXtProt for RXRG: NX_P48443

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48443

    • RXRG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243499.1  NP_001243500.1  NP_008848.1  

    ENSEMBL proteins: 
     ENSP00000352900  
    Reactome Protein details: P48443
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RXRG
    OriGene Protein Over-expression Lysate: RXRG
    OriGene Custom Protein Services for RXRG 
    GenScript Custom Purified and Recombinant Proteins Services for RXRG
    Novus Biologicals RXRG Proteins
    Novus Biologicals RXRG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--


    RXRG for ontologies           About GeneDecksing



    RXRG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RXRG
    R&D Systems Antibodies for RXRG (RXR gamma/NR2B3)
    Cell Signaling Technology (CST) Antibodies for RXRG 
    OriGene Antibodies (see all 2): RXRG
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    GenScript Custom Superior Antibodies Services for RXRG
    Novus Biologicals RXRG Antibodies
    Search for Antibodies for RXRG at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for RXRG

    Assay Products for RXRG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for RXRG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for RXRG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RXRG for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR021780 Nuc_recep-AF1

    Graphical View of Domain Structure for InterPro Entry P48443

    ProtoNet protein and cluster: P48443

    2 Blocks protein families:
    IPB000003 Retinoic acid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding
    domain (By similarity)
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for RXRG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443
    Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in
    response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological
    processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3'
    sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)

         Genatlas biochemistry entry for RXRG:
    retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),gamma subunit,obligate member of
    heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): RXRG
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RXRG
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RXRG:
    hsa-miR-130a* hsa-let-7a-2* hsa-miR-23c hsa-miR-1284 hsa-miR-23b hsa-let-7g* hsa-miR-23a hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmid: RXRG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RXRG (see all 7)
    OriGene shRNA RFP: RXRG
    OriGene siRNA: RXRG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RXRG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RXRG

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RXRG (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RXRG (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RXRG (NM_006917)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRG 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RXRG
    Search LifeMap BioReagents cell lines for RXRG

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRG

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003707steroid hormone receptor activity IEA--
    GO:00048869-cis retinoic acid receptor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    RXRG for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RXRG:
     Decreased viability  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for RXRG: Rxrgtm2Ysa Rxrgtm1Ipc
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rxrg):
     behavior/neurological  mortality/aging  muscle  nervous system  normal 

    RXRG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RXRG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nuclear Receptor transcription pathway
    		Nuclear Receptor transcription pathway1.00
    		Nuclear Receptors0.68
    2Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    3Apoptotic Pathways in Synovial Fibroblasts
    		PPAR Pathway0.66
    		Nuclear Receptor Activation by Vitamin-A0.57
    4Adipogenesis
    		Adipogenesis1.00
    5Vitamin A and carotenoid metabolism
    		Vitamin A and carotenoid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RXRG
        Nuclear Receptor Activation by Vitamin-A
    PPAR Pathway

    5 BioSystems Pathways for RXRG 
        Vitamin A and carotenoid metabolism
    Adipogenesis
    Nuclear Receptors
    Retinoic acid receptors-mediated signaling
    RXR and RAR heterodimerization with other nuclear receptor

    3        Reactome Pathways for RXRG
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression


    5/6         Kegg Pathways  (Kegg details for RXRG) (see all 6):
        PPAR signaling pathway
    Adipocytokine signaling pathway
    Pathways in cancer
    Thyroid cancer
    Small cell lung cancer


    RXRG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RXRG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for RXRG (P484432, 3 ENSP000003529004) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102762, 3, ENSP000002540664MINT-67080 I2D: score=6 STRING: ENSP00000254066
    CHGBP050602, 3MINT-63770 I2D: score=4 
    DCKP277072, 3, ENSP000002866484MINT-8254089 I2D: score=2 STRING: ENSP00000286648
    LRSAM1Q6UWE02, 3, ENSP000003004174MINT-64680 I2D: score=4 STRING: ENSP00000300417
    PNO1Q9NRX12, 3, ENSP000002636574MINT-63772 I2D: score=4 STRING: ENSP00000263657
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007422peripheral nervous system development IEA--
    GO:0007507heart development IEA--
    GO:0007519skeletal muscle tissue development IEA--
    GO:0010467gene expression TAS--


    RXRG for ontologies           About GeneDecksing



    Drugs & Compounds
    for RXRG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RXRG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RXRG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Liarozole hydrochlorideBlocks retinoic acid metabolism[145858-50-0]
    Docosahexaenoic acidRXR agonist[6217-54-5]
    LG 101506Selective RXR modulator[331248-11-4]
    FenretinideSynthetic retinoid. Potent anticancer agent[65646-68-6]
    SR 11237Pan RXR agonist[146670-40-8]

    2 HMDB Compounds for RXRG    About this table
    CompoundSynonyms CAS #PubMed Ids
    9-cis-Retinoic acidTretinoin [usan:ban:inn] (see all 69)----
    Retinoic acidRetinoate (see all 21)302-79-4--

    6 DrugBank Compounds for RXRG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bexarotene-- 153559-49-0targetagonist15632250 17483357 18765556 11702369 16495926 17008586 15897247 14700480 15056048
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8targetagonist19678713 17132853 17491551 17182884 16456186 17006844
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4targetagonist14993281 17161848 16420438 17182884 16456186
    Acitretin-- 55079-83-9targetagonist17139284 17016423 9074840
    AdapaleneAdapaleno [INN-Spanish] (see all 2)106685-40-9targetagonist10651997 17139284 17016423
    Etretinate-- 54350-48-0targetagonist17139284 9298126 17016423

    5 Novoseek chemical compound relationships for RXRG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 51.3 2 15735044 (1), 10070102 (1)
    retinoid 49.9 2 15299084 (1), 15735044 (1)
    vitamin d 33.1 1 17707062 (1)
    lipid 0 2 12175776 (2)
    glucose 0 1 12175776 (1)

    Search CenterWatch for drugs/clinical trials and news about RXRG 

    Transcripts
    for RXRG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RXRG gene (3 alternative transcripts): 
    NM_001256570.1  NM_001256571.1  NM_006917.4  

    Unigene Cluster for RXRG:

    Retinoid X receptor, gamma
    Hs.26550  [show with all ESTs]
    Unigene Representative Sequence: NM_001256570
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359842(uc001gda.3 uc021pea.1) ENST00000470566 ENST00000465764(uc001gdb.2)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): RXRG
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RXRG
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RXRG:
    hsa-miR-130a* hsa-let-7a-2* hsa-miR-23c hsa-miR-1284 hsa-miR-23b hsa-let-7g* hsa-miR-23a hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmid: RXRG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RXRG (see all 7)
    OriGene shRNA RFP: RXRG
    OriGene siRNA: RXRG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RXRG
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RXRG (NM_006917)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRG 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RXRG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RXRG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RXRG

    Additional cDNA sequence: 

    AB307706.1 AB593015.1 AB593016.1 AK312922.1 BC012063.1 CR456705.1 HQ692845.1 NR_033824.1 
    U38480.1 

    6 DOTS entries:

    DT.109788  DT.121348225  DT.40292530  DT.99979837  DT.97838298  DT.97860607 

    24/58 AceView cDNA sequences (see all 58):

    BX092249 BQ681205 BE254038 BG032890 BX118484 CD671089 BE255171 BM564712 
    BM692655 BG030798 BM728015 NM_006917 BG762883 BM720326 BC012063 CR596807 
    BM725085 BI766659 AI368825 BG765952 W96098 BM678895 BM725746 BI768747 

    GeneLoc Exon Structure


    Expression
    for RXRG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RXRG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGATGTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RXRG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerCone Precursor CellsPhotoreceptors, Retina
    BrainFourth VentricleBrain
    BrainHypothalamusBrain
    EyeRetinaEye
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Optic cup structures (Generation of strati...)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)

    See RXRG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RXRG

    SOURCE GeneReport for Unigene cluster: Hs.26550
        SABiosciences Expression via Pathway-Focused PCR Arrays including RXRG: 
              Nuclear Receptors & Coregulators in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RXRG
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RXRG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RXRG
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRG

    Orthologs
    for RXRG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RXRG gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RXRG1 retinoid X receptor, gamma 79(n)
    85.93(a)    		   396231  NM_205294.1  NP_990625.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.8782 Xenopus laevis mRNA sequence 77.7(n)    L11443.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rxrga1 retinoid x receptor, gamma a 72.74(n)
    80.34(a)    		   30464  NM_131217.2  NP_571292.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta usp6
    		 ultraspiracle
    		 34(a)
    		 1 → many
    		 X(1932829-1936344)


    ENSEMBL Gene Tree for RXRG (if available)
    TreeFam Gene Tree for RXRG (if available) 

    Paralogs
    for RXRG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RXRG gene
    ESRRA2  PGR2  ESR22  ESRRB2  HNF4G2  NR2F62  NR2E12  ESRRG2  
    NR3C22  RXRA2  NR2F12  NR3C12  NR2F22  AR2  ESR12  NR2C12  
    HNF4A2  NR2C22  RXRB2  
    18/32 SIMAP similar genes for RXRG using alignment to 2 protein entries:     RXRG_HUMAN (see all proteins) (see all similar genes):
    NR2B3    RXRA    NR2B1    RXRB    NR2B2    HNF4G
    NR2A3    NR2A2    NR2A1    HNF4A    NR2F1    NR2F2
    ERRgamma    NR2F6    NR3B3    ESRRG    NR1B2    PML-RAR

    RXRG for paralogs           About GeneDecksing



    Genomic Variants
    for RXRG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/874 NCBI SNPs in RXRG are shown (see all 874)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs741211281,2
    		C,--136616576(+) AGAACC/TGGAGA 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs782995941,2
    		F,--136616911(+) CCCCAT/CGCTCC 3 -- ds50011Minor allele frequency- C:0.09NA 120
    rs559017101,2
    		C,F,--136616975(+) GGCAAG/ATGAAA 3 -- ut311Minor allele frequency- A:0.12NA 120
    rs563623641,2
    		C,F,--136617163(+) GACAGG/CAAGGG 3 -- ut312Minor allele frequency- C:0.08WA NA 238
    rs799263441,2
    		--136617787(+) TCTGCA/TGAGGC 3 -- int10--------
    rs745828231,2
    		F,--136617851(+) CATTAG/AATGAC 3 -- int11Minor allele frequency- A:0.12WA 118
    rs773837791,2
    		F,--136618027(+) ACAGGC/TACATG 3 -- int11Minor allele frequency- T:0.03WA 118
    rs20426581,2
    		C,F,H,--136618394(+) TGTTAC/TCAATT 3 -- int110Minor allele frequency- T:0.21NS EA WA CSA NA 768
    rs57784481,2
    		C,--136618447(+) AAAAG-/AGTT  
                AGAAA     		3 -- int1 trp30--------
    rs30451551,2
    		C--136618548(+) CACAC-/TCACACA 3 -- int10--------

    HapMap Linkage Disequilibrium report for RXRG (165370159 - 165414592 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RXRG: --
    Human Gene Mutation Database (HGMD): RXRG

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    Disorders / Diseases
    for RXRG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RXRG for disorders           About GeneDecksing

    OMIM gene information: 180247    OMIM disorders: --

    20/27 diseases for RXRG (see all 27):    About MalaCards
    lung cancer    thyroiditis    familial combined hyperlipidemia    functioning pituitary adenoma
    pituitary adenoma    hyperlipidemia    coronary heart disease    insulin resistance
    diabetic retinopathy    essential hypertension    renal cell carcinoma    adenoma
    thyroid carcinoma    hypertension    esophageal cancer    t-cell leukemia
    esophagitis    colon cancer    thyroid cancer    meningioma

    2 Novoseek disease relationships for RXRG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperlipidemia familial combined 69.3 1 17272748 (1)
    tumors 0 3 17707062 (3)

    Genetic Association Database (GAD): RXRG
    Human Genome Epidemiology (HuGE) Navigator: RXRG (18 documents)

    Export disorders for RXRG gene to outside databases

    Publications
    for RXRG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RXRG gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with RXRG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of the human retinoid X receptors. (PubMed id 8034312)1, 3, 9 Almasan A....Evans R.M. (1994)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)1, 4 Feng J....Sommer S.S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Search for genetic variants in the retinoid X receptor-gamma-gene by polymerase chain reaction-single-strand conformation polymorphism in patients with resistance to thyroid hormone without mutations in thyroid hormone receptor beta gene. (PubMed id 15186611)1, 9 Romeo S....Baroni M.G. (2004)
    6. Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. (PubMed id 12175776)4, 9 Wang H....Elbein S.C. (2002)
    7. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. (PubMed id 17272748)1, 9 Nohara A....Mabuchi H. (2007)
    8. Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment. (PubMed id 15299084)1, 9 Klopper J.P....Haugen B.R. (2004)
    9. Physical mapping of the retinoid X receptor B gene in mouse and human. (PubMed id 7806300)1, 9 Nagata T....Taketo M. (1995)
    10. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PubMed id 18269685)1, 9 Hasstedt S.J....Elbein S.C. (2008)

    External Searches for RXRG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RXRG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6258 HGNC: 10479 AceView: RXRG Ensembl:ENSG00000143171 euGenes: HUgn6258
    ECgene: RXRG Kegg: 6258 H-InvDB: RXRG

    Other Databases showing RXRG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RXRG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RXRG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RXRG Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RXRG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RXRG gene:
    Search GeneIP for patents involving RXRG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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