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Aliases & Descriptions for RXRG
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases NR2B3 1 , 2 , 3 OTTHUMP00000060418 2 RXRC 2
Descriptions Nuclear receptor subfamily 2 group B member 3 3 Retinoid X receptor gamma 3 retinoic acid receptor RXR-gamma 2 retinoid X receptor, gamma 2 retinoid X receptor-gamma 2
Search outside databases for aliases for RXRG genePrevious GC identifers: GC01M163005 GC01M161021 GC01M162066 GC01M162557 GC01M162102
Summaries for RXRG (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for RXRG : This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which areinvolved in mediating the antiproliferative effects of retinoic acid (RA). This receptor formsdimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNAbinding and transcriptional function on their respective response elements. This gene is expressedat significantly lower levels in non-small cell lung cancer cells. Alternate transcriptionalsplice variants, encoding different isoforms, have been characterized. [provided by RefSeq] UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443 Function : Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cisretinoic acid (9C-RA) (By similarity)
Gene Wiki entry for RXRG (Retinoid_X_receptor_gamma)
Genomic Location for RXRG
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RXRG gene Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q22-q23 RXRG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M163636:
(about GC identifiers )
Start:
163,636,974 bp from pter
End:
163,681,054 bp from pter
Size:
44,081 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for RXRG
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443 (See
protein sequence )Recommended Name: Retinoic acid receptor RXR-gamma Size : 463 amino acids; 50871 Da
Subcellular location : Nucleus (By similarity)
PDB structures from and Proteopedia : 2GL8 (3D)
 
Secondary accessions : A6NIP1 Q6IBU7
REFSEQ proteins (2 alternative transcripts):
NP_001009598.1 NP_008848.1 ENSEMBL proteins: ENSP00000352900 ENSP00000356866 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RXRG 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table Antibodies for RXRG: Assays for RXRG:
Protein
Domains/ Families for RXRG(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P48443 ProtoNet protein and cluster: P48443
2 Blocks protein families : IPB000003 Retinoic acid receptor signature IPB001723 Steroid hormone receptor signature UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443 Domain : Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and aC-terminal steroid-binding domain (By similarity) Similarity : Belongs to the nuclear hormone receptor family. NR2 subfamilySimilarity : Contains 1 nuclear receptor DNA-binding domain
Gene Function for RXRG
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Inhib. RNA: Invitrogen RNAi Products for gene knock-down (RXRG ) Millipore RNAi Products for the Analysis of RXRG Gene knock-down Abnova Chimera RNAi Products for Gene knock-down (RXRG )
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_006917 Applied Biosystems Silencer ® siRNAs for RXRG Sigma-Aldrich siRNA and siRNA Panels for RXRG Sigma-Aldrich shRNA Panels and shRNA for RXRG Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001009598                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001009598                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001009598  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006917 UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443 Function : Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cisretinoic acid (9C-RA) (By similarity)
Genatlas biochemistry entry for RXRG :retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),gammasubunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptorsuperfamily
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rxrg) :5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
):
About this table
Pathways & Interactions for RXRG
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for RXRG (Your Favorite Gene powered by Ingenuity) (see all 8
) Gene Network CentralTM Interacting Genes and Proteins Network for RXRG 5/53 Interacting proteins for RXRG (P48443 2 ENSP00000352900 3 ) via UniProtKB, MINT, and/or STRING (see all 53
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA --
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Drugs & Compounds for RXRG (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for RXRG
Compounds for RXRG available from Tocris Bioscience Compound Action
CAS
number Liarozole hydrochloride Blocks retinoic acid metabolism [145858-50-0] Fenretinide Synthetic retinoid. Potent anti-cancer agent [65646-68-6] Retinoic acid Endogenous retinoic acid receptor agonist. Also modulates PPARdelta [302-79-4]
About this table 2 Novoseek chemical compound relationships for RXRG gene
About this table
Transcripts for RXRG(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
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Sigma-Aldrich ,
shRNA from
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OriGene ,
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Inhib. RNA: Invitrogen RNAi Products for gene knock-down (RXRG ) Millipore RNAi Products for the Analysis of RXRG Gene knock-down Abnova Chimera RNAi Products for Gene knock-down (RXRG )
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_006917 Sigma-Aldrich siRNA and siRNA Panels for RXRG Sigma-Aldrich shRNA Panels and shRNA for RXRG Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001009598 NM_006917
REFSEQ mRNAs for RXRG gene (2 alternative transcripts): NM_001009598.1 NM_006917.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001009598 NM_006917
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001009598                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001009598                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001009598  
Additional cDNA sequence: AB307706.1 AK312922.1 BC012063.1 CR456705.1 CR596807.1 U38480.1
6 DOTS entries : DT.109788 DT.121348225 DT.40292530 DT.99979837 DT.97838298 DT.97860607
24/58 AceView cDNA sequences (see all 58
):BX092249 BM692655 BM720326 BX118484 NM_006917 CD671089 CR596807 BE255171 BI766659 BQ681205 BE254038 BC012063 BG030798 BG032890 BM725085 BM728015 BM564712 BG762883 CR456705 U38480 AA298024 BE349212 AL538345 BI768747
highest scoring ESTs for RXRG :U38480 AA297997 AA298024 AI693273 AL538345 AW951107 BC012063 BE254038 BE255171 BG030798
Unigene Cluster for RXRG: Retinoid X receptor, gamma Hs.26550 [show with all ESTs ] Unigene Representative Sequence: NM_006917 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000359842
ENST00000367891
Expression for RXRG
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RXRG expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RXRG 1 / 2 / 3
5 probe-sets matching RXRG gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAGATGTTGGSOURCE GeneReport for Unigene cluster: Hs.26550 Expression variation in blood from EXPOLDB for RXRG
Orthologs for RXRG
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RXRG gene from 5/8 species (see all 8
)
About this table Species with no ortholog for RXRG ENSEMBL Gene Tree for RXRG Paralogs for RXRG (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RXRG gene RXRA 2 RXRB 2
SNPs/Variants for RXRG (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RXRG (up to first 250kb)
Disorders & Mutations for RXRG
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 180247 2 Novoseek disease relationships for RXRG gene
About this table Human Gene Mutation Database : RXRG Genetic Association Database: RXRG Human Genome Epidemiology Navigator: RXRG (7 documents)
Medical News for RXRG (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RXRG (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/56 PubMed articles for RXRG gene (see all 56
): Chromosomal localization of the human retinoid X receptors. (PubMed id 8034312) 1, 2, 3 Almasan A....Evans R.M. (1994) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645) 3, 6 Feng J....Sommer S.S. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Search for genetic variants in the retinoid X receptor-gamma-gene by polymerase chain reaction-single-strand conformation polymorphism in patients with resistance to thyroid hormone without mutations in thyroid hormone receptor beta gene. (PubMed id 15186611) 1, 3 Romeo S....Baroni M.G. (2004) Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. (PubMed id 12175776) 1, 6 Wang H....Elbein S.C. (2002) High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. (PubMed id 17272748) 1, 3 Nohara A....Mabuchi H. (2007) Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment. (PubMed id 15299084) 1, 3 Klopper J.P....Haugen B.R. (2004) Physical mapping of the retinoid X receptor B gene in mouse and human. (PubMed id 7806300) 1, 3 Nagata T....Taketo M. (1995) Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PubMed id 18269685) 1, 3 Hasstedt S.J....Elbein S.C. (2008)
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Genome Databases showing RXRG
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing RXRG
(According to HUGE )
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Specialized Databases showing RXRG (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RXRG (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for RXRG:
Tocris compounds for RXRG
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