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RXRG Gene

protein-coding   GIFtS: 66
GCID: GC01M165370

Retinoid X Receptor, Gamma

  See RXRG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinoid X Receptor, Gamma1 2
Nuclear Receptor Subfamily 2 Group B Member 31 2 3
NR2B32 3
RXRC2
Retinoic Acid Receptor RXR-Gamma2
Retinoid X Receptor Gamma3

External Ids:    HGNC: 104791   Entrez Gene: 62582   Ensembl: ENSG000001431717   OMIM: 1802475   UniProtKB: P484433   

Export aliases for RXRG gene to outside databases

Previous GC identifers: GC01M163005 GC01M161021 GC01M162066 GC01M162557 GC01M162102 GC01M163636 GC01M136616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RXRG Gene:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in
mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid,
thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their
respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer
cells. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jun 2010)

GeneCards Summary for RXRG Gene:
RXRG (retinoid X receptor, gamma) is a protein-coding gene. Diseases associated with RXRG include non-functioning pituitary adenoma, and functioning pituitary adenoma. GO annotations related to this gene include 9-cis retinoic acid receptor activity and sequence-specific DNA binding. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By
similarity)

summary for RXRG Gene:
Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding
partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors
(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding
efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully
elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR
signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major
isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely
distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.

Gene Wiki entry for RXRG (Retinoid X receptor gamma) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RXRG gene promoter:
         Egr-3   STAT1   HSF2   IRF-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RXRG promoter sequence
   Search Chromatin IP Primers for RXRG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RXRG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22-q23

RXRG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXRG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M165370:  view genomic region     (about GC identifiers)

Start:
165,370,159 bp from pter      End:
165,414,592 bp from pter
Size:
44,434 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443 (See protein sequence)
Recommended Name: Retinoic acid receptor RXR-gamma  
Size: 463 amino acids; 50871 Da
Subunit: Homodimer (By similarity). Heterodimer with a RAR molecule (By similarity). Binds DNA preferentially as a
RAR/RXR heterodimer (By similarity)
1 PDB 3D structure from and Proteopedia for RXRG:
2GL8 (3D)    
Secondary accessions: A6NIP1 Q6IBU7

Explore the universe of human proteins at neXtProt for RXRG: NX_P48443

Explore proteomics data for RXRG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys418
  • Modification sites at PhosphoSitePlus

  • See RXRG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243499.1  NP_001243500.1  NP_008848.1  

    ENSEMBL proteins: 
     ENSP00000352900  
    Reactome Protein details: P48443

    RXRG Human Recombinant Protein Products:

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    Novus Biologicals RXRG Proteins
    Novus Biologicals RXRG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RXRG 

    RXRG Antibody Products:

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    R&D Systems Antibodies for RXRG (RXR gamma/NR2B3)
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RXRG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Retinoid X receptor-gamma
    2B. Retinoid X receptors

    Selected InterPro protein domains (see all 7):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR021780 Nuc_recep-AF1

    Graphical View of Domain Structure for InterPro Entry P48443

    ProtoNet protein and cluster: P48443

    2 Blocks protein domains:
    IPB000003 Retinoic acid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: RXRG_HUMAN, P48443
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain (By similarity)
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with RXRG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RXRG_HUMAN, P48443
    Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
    elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
    biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
    tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By
    similarity)

         Genatlas biochemistry entry for RXRG:
    retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),gamma subunit,obligate
    member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:00048869-cis retinoic acid receptor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RXRG           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RXRG:
     Decreased viability  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rxrg):
     behavior/neurological  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with RXRG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RXRG: Rxrgtm2Ysa Rxrgtm1Ipc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RXRG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RXRG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RXRG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RXRG

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate RXRG:
    hsa-miR-130a* hsa-let-7a-2* hsa-miR-23c hsa-miR-1284 hsa-miR-23b hsa-let-7g* hsa-miR-23a hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidRXRG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RXRG
    Predesigned siRNA for gene silencing in human, mouse, rat RXRG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RXRG (NM_006917)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRG
    Addgene plasmids for RXRG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RXRG_HUMAN, P48443: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with RXRG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RXRG About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Nuclear Receptor Activation by Vitamin-A0.57
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Glioma
    Non-small cell lung cancer0.51
    5Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism


    Find genes that share SuperPaths with RXRG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RXRG
        Nuclear Receptor Activation by Vitamin-A
    PPAR Pathway

    5 BioSystems Pathways for RXRG
        Adipogenesis
    Nuclear Receptors
    Vitamin A and carotenoid metabolism
    RXR and RAR heterodimerization with other nuclear receptor
    Retinoic acid receptors-mediated signaling

    1 Reactome Pathway for RXRG
        Nuclear Receptor transcription pathway


    Selected Kegg Pathways  (Kegg details for RXRG) (see all 8):
        PPAR signaling pathway
    Thyroid hormone signaling pathway
    Adipocytokine signaling pathway
    Pathways in cancer
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RXRG: 
              Nuclear Receptors & Coregulators in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RXRG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RXRG (P484431, 2, 3 ENSP000003529004) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102761, 2, 3, ENSP000002540664EBI-712405,EBI-413374 MINT-67080 I2D: score=6 STRING: ENSP00000254066
    CHGBP050602, 3MINT-63770 I2D: score=4 
    DCKP277072, 3, ENSP000002866484MINT-8254089 I2D: score=2 STRING: ENSP00000286648
    NR1H2P550552, 3, ENSP000002537274MINT-8263929 I2D: score=5 STRING: ENSP00000253727
    LRSAM1Q6UWE02, 3, ENSP000003004174MINT-64680 I2D: score=4 STRING: ENSP00000300417
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007422peripheral nervous system development IEA--
    GO:0007507heart development IEA--
    GO:0007519skeletal muscle tissue development IEA--

    Find genes that share ontologies with RXRG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RXRG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FluorobexaroteneRXR agonist[1190848-23-7]
    SR 11237Pan RXR agonist[146670-40-8]
    HX 531RXR antagonist[188844-34-0]
    UVI 3003RXR antagonist[847239-17-2]
    CD 3254Potent and selective RXRalpha agonist.[196961-43-0]

    2 HMDB Compounds for RXRG    About this table
    CompoundSynonyms CAS #PubMed Ids
    9-cis-Retinoic acidTretinoin [usan:ban:inn] (see all 69)----
    Retinoic acidRetinoate (see all 21)302-79-4--

    6 DrugBank Compounds for RXRG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bexarotene-- 153559-49-0targetagonist15632250 17483357 18765556 11702369 16495926 17008586 15897247 14700480 15056048
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8targetagonist19678713 17132853 17491551 17182884 16456186 17006844
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4targetagonist14993281 17161848 16420438 17182884 16456186
    Acitretin-- 55079-83-9targetagonist17139284 17016423 9074840
    AdapaleneAdapaleno [INN-Spanish] (see all 2)106685-40-9targetagonist10651997 17139284 17016423
    Etretinate-- 54350-48-0targetagonist17139284 9298126 17016423

    2 IUPHAR Ligands for RXRG (Retinoid X receptor-gamma)    About this table
    LigandTypeActionAffinityPubmed IDs
    9-cis-retinoic acid
    AgonistAgonist7 - 88380496 1309942 8837780 1312497 7791761 1310260
    bexarotene
    AgonistAgonist7.5410052980 10637371 8071941

    5 Novoseek inferred chemical compound relationships for RXRG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 51.3 2 15735044 (1), 10070102 (1)
    retinoid 49.9 2 15299084 (1), 15735044 (1)
    vitamin d 33.1 1 17707062 (1)
    lipid 0 2 12175776 (2)
    glucose 0 1 12175776 (1)



    Find genes that share compounds with RXRG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RXRG gene (3 alternative transcripts): 
    NM_001256570.1  NM_001256571.1  NM_006917.4  

    Unigene Cluster for RXRG:

    Retinoid X receptor, gamma
    Hs.26550  [show with all ESTs]
    Unigene Representative Sequence: NM_001256570
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359842(uc001gda.3 uc021pea.1) ENST00000470566 ENST00000465764(uc001gdb.2)

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    hsa-miR-130a* hsa-let-7a-2* hsa-miR-23c hsa-miR-1284 hsa-miR-23b hsa-let-7g* hsa-miR-23a hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidRXRG 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RXRG (NM_006917)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRG
    Addgene plasmids for RXRG 
    Primer
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    OriGene qPCR primer pairs and template standards for RXRG
    OriGene qSTAR qPCR primer pairs in human, mouse for RXRG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RXRG
      QuantiTect SYBR Green Assays in human, mouse, rat RXRG
      QuantiFast Probe-based Assays in human, mouse, rat RXRG

    Additional mRNA sequence: 

    AB307706.1 AB593015.1 AB593016.1 AK312922.1 BC012063.1 CR456705.1 HQ692845.1 NR_033824.1 
    U38480.1 

    6 DOTS entries:

    DT.109788  DT.121348225  DT.40292530  DT.99979837  DT.97838298  DT.97860607 

    Selected AceView cDNA sequences (see all 58):

    BE255171 BG032890 BG030798 BG762883 BM728015 BM564712 CD671089 CR596807 
    BM692655 BQ681205 BM725085 NM_006917 BC012063 BE254038 BI766659 BX092249 
    BM720326 BX118484 AI693273 U38480 BE349212 AA298024 F19049 BM678895 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RXRG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGTTGG
    RXRG Expression
    About this image


    RXRG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cone Precursor Cells Outer Nuclear Layer
             Optic cup structures
     
     Neurons
             Cone Precursor Cells Outer Nuclear Layer
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    RXRG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RXRG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26550
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RXRG: 
              Nuclear Receptors & Coregulators in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RXRG
    OriGene qSTAR qPCR primer pairs in human, mouse for RXRG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RXRG
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RXRG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxrg1 , 5 retinoid X receptor gamma1, 5 90.21(n)1
    98.27(a)1
      1 (74.99 cM)5
    201831  NM_009107.31  NP_033133.11 
     1675983845 
    chicken
    (Gallus gallus)
    Aves RXRG1 retinoid X receptor, gamma 78.79(n)
    85.71(a)
      396231  NM_205294.1  NP_990625.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8782 Xenopus laevis mRNA sequence 77.7(n)    L11443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rxrga1 retinoid x receptor, gamma a 74.6(n)
    82.71(a)
      30464  NM_131217.2  NP_571292.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta usp6
    ultraspiracle
    36(a)
    1 → many
    X(1932829-1936344)


    ENSEMBL Gene Tree for RXRG (if available)
    TreeFam Gene Tree for RXRG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RXRG gene
    RXRA2  NR2F12  NR2F22  HNF4G2  NR2C12  NR2F62  NR2E12  HNF4A2  
    RXRB2  NR2C22  
    Selected SIMAP similar genes for RXRG using alignment to 2 protein entries:     RXRG_HUMAN (see all proteins) (see all similar genes):
    NR2B3    RXRA    NR2B1    RXRB    NR2B2    HNF4G
    NR2A3    NR2A2    NR2A1    HNF4A    NR2F1    NR2F2
    ERRgamma    ESRRG    NR2F6    NR3B3    NR1B2    PML-RAR

    Find genes that share paralogs with RXRG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RXRG (see all 1031)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138534921,2
    C--136618090(+) CCAATTT/-TTTTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs566867891,2
    C--136618102(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int10--------
    rs57784481,2
    C--136618446(+) AAAAG-/AGTT  
            
    AGAAA
    3 -- int1 trp30--------
    rs341217071,2
    C--136618447(+) AAAGA-/AGTT/ 
    GTT
    /GTTC
    GAAAA
    6 -- int1 cds10--------
    rs30451531,2
    C--136618448(+) AAGAG-/TT    
       
    /TTAG
    AAAAT
    3 -- int1 trp30--------
    rs354450561,2
    C--136623875(+) AACTT-/AAAAAA 3 -- int11Minor allele frequency- A:0.00CSA 2
    rs2011124441,2
    C--136623887(-) CTGGGG/TTNNNN 3 -- int10--------
    rs577826681,2
    C--136634153(+) AAAAA-/A/AA  
      A
    /AAAA
    GAAGG
    3 -- int11NA 2
    rs586553501,2
    C--165372175(+) ACACT-/CTTACAC 3 -- int10--------
    rs761885901,2
    C,F--165375439(+) TGCTAG/CATGGC 3 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for RXRG (165370159 - 165414592 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RXRG: --
    Human Gene Mutation Database (HGMD): RXRG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RXRG
    DNA2.0 Custom Variant and Variant Library Synthesis for RXRG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180247    OMIM disorders: --

    3 diseases for RXRG:    
    About MalaCards
    non-functioning pituitary adenoma    functioning pituitary adenoma    lung cancer


    Find genes that share disorders with RXRG           About GenesLikeMe

    2 Novoseek inferred disease relationships for RXRG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperlipidemia familial combined 69.3 1 17272748 (1)
    tumors 0 3 17707062 (3)

    Genetic Association Database (GAD): RXRG
    Human Genome Epidemiology (HuGE) Navigator: RXRG (18 documents)

    Export disorders for RXRG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RXRG gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with RXRG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PubMed id 18269685)1, 4, 9 Hasstedt S.J....Elbein S.C. (Ann. Hum. Genet. 2008)
    2. Chromosomal localization of the human retinoid X receptors. (PubMed id 8034312)1, 3, 9 Almasan A....Evans R.M. (Genomics 1994)
    3. Genome-wide association study of personality traits in bipolar patients. (PubMed id 21368711)1, 4 Alliey-Rodriguez N....Gershon E.S. (Psychiatr. Genet. 2011)
    4. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PubMed id 20855565)1, 4 Peloso G.M....Brousseau M.E. (J. Lipid Res. 2010)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). (PubMed id 19754311)1, 4 Le Clerc S....Zagury J.F. (J. Infect. Dis. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6258 HGNC: 10479 AceView: RXRG Ensembl:ENSG00000143171 euGenes: HUgn6258
    ECgene: RXRG Kegg: 6258 H-InvDB: RXRG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RXRG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RXRG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RXRG gene:
    Search GeneIP for patents involving RXRG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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