Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RXRB Gene

protein-coding   GIFtS: 71
GCID: GC06M033161

Retinoid X Receptor, Beta

  See RXRB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Retinoid X Receptor, Beta1 2     RCoR-12
Nuclear Receptor Subfamily 2 Group B Member 21 2 3     MHC Class I Promoter Binding Protein2
NR2B22 3     Retinoic Acid Receptor RXR-Beta2
DAUDI62     Retinoid X Receptor Beta3
H-2RIIBP2     

External Ids:    HGNC: 104781   Entrez Gene: 62572   Ensembl: ENSG000002042317   OMIM: 1802465   UniProtKB: P287023   

Export aliases for RXRB gene to outside databases

Previous GC identifers: GC06M033164 GC06M033208 GC06M033270 GC06M032877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RXRB Gene:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in
mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid
hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective
response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome
6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Jul 2012)

GeneCards Summary for RXRB Gene:
RXRB (retinoid X receptor, beta) is a protein-coding gene. Diseases associated with RXRB include x-linked adrenal hypoplasia congenita. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA)

summary for RXRB Gene:
Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding
partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors
(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding
efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully
elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR
signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major
isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely
distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.

Gene Wiki entry for RXRB (Retinoid X receptor beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RXRB gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRXRB promoter sequence
   Search Chromatin IP Primers for RXRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RXRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RXRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXRB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033161:  view genomic region     (about GC identifiers)

Start:
33,161,365 bp from pter      End:
33,168,630 bp from pter
Size:
7,266 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167247 4,635,129-4,642,193      Chr6-,NT_167245 4,442,672-4,449,739      Chr6-,NT_113891.2 4,605,201-4,612,266     
Chr6-,NT_167246 4,618,680-4,625,748      Chr6-,NT_167248 4,393,587-4,400,655     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702 (See protein sequence)
Recommended Name: Retinoic acid receptor RXR-beta  
Size: 533 amino acids; 56922 Da
Subunit: Homodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR
heterodimer
Sequence caution: Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RXRB:
1H9U (3D)        1UHL (3D)    
Secondary accessions: P28703 Q59G65 Q5JP92 Q5STQ1
Alternative splicing: 2 isoforms:  P28702-1   P28702-3   

Explore the universe of human proteins at neXtProt for RXRB: NX_P28702

Explore proteomics data for RXRB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys452, Lys488
  • Modification sites at PhosphoSitePlus

  • See RXRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257330.1  NP_068811.1  

    ENSEMBL proteins: 
     ENSP00000363817   ENSP00000363812   ENSP00000431369   ENSP00000439222   ENSP00000415561  
    Reactome Protein details: P28702

    RXRB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for RXRB
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RXRB
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RXRB
    GenScript Custom Purified and Recombinant Proteins Services for RXRB
    Novus Biologicals RXRB Protein
    Novus Biologicals RXRB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RXRB 

     
    antibodies-online proteins for RXRB (5 products) 

     
    antibodies-online peptides for RXRB

    RXRB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RXRB
    R&D Systems Antibodies for RXRB (RXR beta/NR2B2)
    Cell Signaling Technology (CST) Antibodies for RXRB 
    OriGene Antibodies for RXRB
    OriGene Custom Antibody Services for RXRB
    Novus Biologicals RXRB Antibodies
    Abcam antibodies for RXRB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for RXRB
    antibodies-online antibodies for RXRB (58 products) 

    RXRB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RXRB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RXRB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RXRB 
    antibodies-online kits for RXRB (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Retinoid X receptor-beta
    2B. Retinoid X receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR000003 Retinoid-X_rcpt/HNF4

    Graphical View of Domain Structure for InterPro Entry P28702

    ProtoNet protein and cluster: P28702

    2 Blocks protein domains:
    IPB000003 Retinoic acid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with RXRB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RXRB_HUMAN, P28702
    Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
    elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
    biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
    tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA)

         Genatlas biochemistry entry for RXRB:
    retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),beta subunit,obligate member
    of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1662118
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003713transcription coactivator activity TAS1662118
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA7990953
    GO:00048869-cis retinoic acid receptor activity IEA--
         
    Find genes that share ontologies with RXRB           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RXRB:
     G0/1 arrest  Increased G1 DNA content 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rxrb) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 

    Find genes that share phenotypes with RXRB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RXRB: Rxrbtm1Ipc Rxrbtm1Mma Rxrbtm1Rev

       genOway: Develop your customized and physiologically relevant rodent model for RXRB

    miRNA
    Products:
        
    miRTarBase miRNAs that target RXRB:
    hsa-mir-335-5p (MIRT016771), hsa-mir-26b-5p (MIRT028819), hsa-mir-197-3p (MIRT004176), hsa-mir-484 (MIRT042213), hsa-let-7b-5p (MIRT051998), hsa-mir-92a-3p (MIRT049481), hsa-mir-346 (MIRT004235)

    Block miRNA regulation of human, mouse, rat RXRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RXRB (see all 15):
    hsa-miR-520f hsa-miR-615-5p hsa-miR-627 hsa-miR-622 hsa-miR-324-3p hsa-miR-488 hsa-miR-144 hsa-miR-214*
    SwitchGear 3'UTR luciferase reporter plasmidRXRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RXRB
    Predesigned siRNA for gene silencing in human, mouse, rat RXRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RXRB

    Clone
    Products:
         
    OriGene clones in human, mouse for RXRB (see all 6)
    OriGene ORF clones in mouse, rat for RXRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RXRB (NM_021976)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RXRB
    Browse ESI BIO Cell Lines and PureStem Progenitors for RXRB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RXRB_HUMAN, P28702: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA7990953
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with RXRB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RXRB About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Nuclear Receptor Activation by Vitamin-A0.57
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Glioma
    Non-small cell lung cancer0.51
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35


    Find genes that share SuperPaths with RXRB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RXRB
        Nuclear Receptor Activation by Vitamin-A
    Oct4 in Mammalian ESC Pluripotency
    PPAR Pathway

    1 GeneGo (Thomson Reuters) Pathway for RXRB
        Transcription Sin3 and NuRD in transcription regulation

    2 BioSystems Pathways for RXRB
        Nuclear Receptors
    Vitamin A and carotenoid metabolism

    1 Reactome Pathway for RXRB
        Nuclear Receptor transcription pathway


    Selected Kegg Pathways  (Kegg details for RXRB) (see all 8):
        PPAR signaling pathway
    Thyroid hormone signaling pathway
    Adipocytokine signaling pathway
    Pathways in cancer
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RXRB: 
              Nuclear Receptors & Coregulators in human mouse rat
              Huntington's Disease in human mouse rat
              Cancer Drug Resistance in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RXRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RXRB (P287021, 2, 3 ENSP000003638124) via UniProtKB, MINT, STRING, and/or I2D (see all 624)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1BQ009751, 3EBI-748576,EBI-1055161 I2D: score=1 
    HSP90B1P146252, 3MINT-7947479 I2D: score=1 
    NUDT21O438092, 3MINT-7947479 I2D: score=1 
    RARAP102762, 3, ENSP000002540664MINT-67313 I2D: score=5 STRING: ENSP00000254066
    SPOPO437912, 3, ENSP000002403274MINT-67766 I2D: score=5 STRING: ENSP00000240327
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001893maternal placenta development IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with RXRB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RXRB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FluorobexaroteneRXR agonist[1190848-23-7]
    SR 11237Pan RXR agonist[146670-40-8]
    HX 531RXR antagonist[188844-34-0]
    UVI 3003RXR antagonist[847239-17-2]
    CD 3254Potent and selective RXRalpha agonist.[196961-43-0]

    2 HMDB Compounds for RXRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    9-cis-Retinoic acidTretinoin [usan:ban:inn] (see all 69)----
    Retinoic acidRetinoate (see all 21)302-79-4--

    Selected DrugBank Compounds for RXRB (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bexarotene-- 153559-49-0targetagonist15632250 17483357 18765556 11702369 16495926 17008586 15897247 17139284 14700480 17016423 15056048
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8targetagonist18321241 19678713 17132853 16109390 17491551 16277658 16420438
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4targetagonist16392701 16109390 15379735 17184907 16420438
    AdapaleneAdapaleno [INN-Spanish] (see all 2)106685-40-9targetagonist10651997 17139284 17016423
    Tazarotene-- 118292-40-3targetagonist10828316 17139284 17016423
    6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid-- --target--17139284 17016423
    Acitretin-- 55079-83-9targetagonist17139284 17016423
    Etretinate-- 54350-48-0targetagonist17139284 17016423
    (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID-- --target--10592235
    N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE-- --target--10592235

    2 IUPHAR Ligands for RXRB (Retinoid X receptor-beta)    About this table
    LigandTypeActionAffinityPubmed IDs
    LG100754
    AntagonistAntagonist811463859 11877384 8837780
    bexarotene
    AgonistAgonist7.710052980 10637371 8071941

    5 Novoseek inferred chemical compound relationships for RXRB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 75 23 1314168 (3), 8393143 (1), 7821715 (1), 10704832 (1) (see all 17)
    retinoid 70.9 9 12767074 (2), 10704832 (1), 15958702 (1), 9636132 (1)
    vitamin d 46.2 6 8389356 (1), 8631908 (1), 9717845 (1), 19811264 (1)
    oligonucleotide 0.95 1 15585599 (1)
    estrogen 0 4 8384307 (2), 7740175 (1)



    Find genes that share compounds with RXRB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RXRB gene (2 alternative transcripts): 
    NM_001270401.1  NM_021976.4  

    Unigene Cluster for RXRB:

    Retinoid X receptor, beta
    Hs.388034  [show with all ESTs]
    Unigene Representative Sequence: NM_001270401
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374685(uc011dqr.2) ENST00000374680(uc003odb.3 uc003odc.3 uc011dqs.1)
    ENST00000483281 ENST00000483821 ENST00000481441(uc003ode.1) ENST00000544186
    ENST00000413614(uc011dqt.1 uc011dqu.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RXRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RXRB (see all 15):
    hsa-miR-520f hsa-miR-615-5p hsa-miR-627 hsa-miR-622 hsa-miR-324-3p hsa-miR-488 hsa-miR-144 hsa-miR-214*
    SwitchGear 3'UTR luciferase reporter plasmidRXRB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RXRB
    Predesigned siRNA for gene silencing in human, mouse, rat RXRB
    Clone
    Products:
         
    OriGene clones in human, mouse for RXRB (see all 6)
    OriGene ORF clones in mouse, rat for RXRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RXRB (NM_021976)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RXRB
    OriGene qSTAR qPCR primer pairs in human, mouse for RXRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RXRB
      QuantiTect SYBR Green Assays in human, mouse, rat RXRB
      QuantiFast Probe-based Assays in human, mouse, rat RXRB

    Additional mRNA sequence: 

    AB209244.1 AK225842.1 AK302125.1 BC001167.1 BT007280.1 HQ692844.1 HQ709179.1 M84820.1 
    U00961.1 X63522.1 X65463.1 

    15 DOTS entries:

    DT.118619  DT.100811035  DT.91841173  DT.118621  DT.100798333  DT.100029702  DT.100811028  DT.448809 
    DT.95145990  DT.100798335  DT.75187712  DT.100767296  DT.100798340  DT.100830297  DT.121346999 

    Selected AceView cDNA sequences (see all 297):

    AU105238 AA918367 CR618812 AI888632 AW026020 BE395926 BM549884 AW008891 
    BI906740 F13008 AA195311 BI962952 BF875016 AI003461 AI608692 BM999880 
    AL044221 AL047110 AI669725 NM_021976 BE328430 BM783602 AA348789 BM014020 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RXRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTGCCC
    RXRB Expression
    About this image


    RXRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 10 entries
             Odontoblasts Dentin
             Dentin
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
    RXRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RXRB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388034

    UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702
    Tissue specificity: Expressed in a variety of tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RXRB: 
              Nuclear Receptors & Coregulators in human mouse rat
              Huntington's Disease in human mouse rat
              Cancer Drug Resistance in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RXRB
    OriGene qSTAR qPCR primer pairs in human, mouse for RXRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RXRB
    QuantiTect SYBR Green Assays in human, mouse, rat RXRB
    QuantiFast Probe-based Assays in human, mouse, rat RXRB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RXRB gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxrb1 , 5 retinoid X receptor beta1, 5 91.67(n)1
    96.56(a)1
      17 (17.98 cM)5
    201821  NM_001205214.11  NP_001192143.11 
     340318125 
    lizard
    (Anolis carolinensis)
    Reptilia RXRB6
    retinoid X receptor, beta
    64(a)
    1 ↔ 1
    GL344340.1(6385-31434)
    African clawed frog
    (Xenopus laevis)
    Amphibia S73269.12   -- 77.7(n)    S73269.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131275.12   -- 81.01(n)   30530  NM_131275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta usp3 metamorphosis ecdysteroid hormone
    receptor
    47(a)   2C7   --


    ENSEMBL Gene Tree for RXRB (if available)
    TreeFam Gene Tree for RXRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RXRB gene
    RXRA2  RXRG2  NR2F12  NR2F22  HNF4G2  NR2C12  NR2F62  NR2E12  
    HNF4A2  NR2C22  
    Selected SIMAP similar genes for RXRB using alignment to 6 protein entries:     RXRB_HUMAN (see all proteins) (see all similar genes):
    NR2B2    NR2C2    RXRA    NR2B3    RXRG    NR5A2
    NR2B1    HNF4alpha    PPARG    RORA    DKFZp779O0162    THRB
    HNF4G    NR2C1    NR2A3    NR3C2    ESR1    NR1I3

    Find genes that share paralogs with RXRB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RXRB (see all 205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421491971,2
    --33081209(+) GGAGAC/GAGAGC 2 -- int10--------
    rs1511983601,2
    --33081281(+) AAGACC/GCCTGG 2 -- int10--------
    rs1404745831,2
    --33081452(+) TTGCAA/GCCCTC 4 G syn10--------
    rs1862328721,2
    C--33081489(+) CTACAC/GGGAAA 2 -- int10--------
    rs2006191151,2
    C,F--33081492(+) CAGGGA/TAAGGG 2 -- int11Minor allele frequency- T:0.01EU 875
    rs1500220091,2
    C--33081515(+) GAAGGC/TTGCAT 2 -- int10--------
    rs1914761141,2
    --33081522(+) GCATGG/TAGACA 2 -- int10--------
    rs178479331,2
    C,F--33081545(-) GGAAAC/GAGACT 2 -- int15Minor allele frequency- G:0.11CSA WA NA 243
    rs27445291,2
    C--33081569(-) TTTAAA/G/TTTTTG 2 -- int15MN 404
    rs27445281,2
    C--33081627(-) ACTGGA/G/TTCATC 2 -- int15MN 404

    HapMap Linkage Disequilibrium report for RXRB (33161365 - 33168630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RXRB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885768CNV Loss21882294
    nsv830634CNV Loss17160897
    nsv522719CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RXRB
    DNA2.0 Custom Variant and Variant Library Synthesis for RXRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 180246    OMIM disorders: --

    1 disease for RXRB:    
    About MalaCards
    x-linked adrenal hypoplasia congenita

    1 disease from the University of Copenhagen DISEASES database for RXRB:
    Wegener's granulomatosis

    Find genes that share disorders with RXRB           About GenesLikeMe

    5 Novoseek inferred disease relationships for RXRB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wegeners granulomatosis 44.7 2 19811264 (1)
    vasculitis 25.7 2 19811264 (2)
    schizophrenia 0 2 11840500 (2)
    breast cancer 0 2 12767074 (1)
    tumors 0 2 8180126 (1)

    Genetic Association Database (GAD): RXRB
    Human Genome Epidemiology (HuGE) Navigator: RXRB (25 documents)

    Export disorders for RXRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RXRB gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with RXRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patients. (PubMed id 19811264)1, 4, 9 KAolsch A.I....Yard B.A. (Autoimmunity 2009)
    2. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (PubMed id 11840500)1, 4, 9 Ishiguro H....Arinami T. (Am. J. Med. Genet. 2002)
    3. Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals. (PubMed id 8381386)1, 2, 9 Fleischhauer K.... Yang S.Y. (Hum. Genet. 1993)
    4. Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. (PubMed id 1315958)1, 2, 9 Fleischhauer K....Yang S.Y. (Nucleic Acids Res. 1992)
    5. Mapping of RXRB to human chromosome 6p21.3. (PubMed id 8257090)1, 3, 9 Fitzgibbon J....Povey S. (Ann. Hum. Genet. 1993)
    6. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. (PubMed id 1310259)1, 2, 9 Leid M....Chambon P. (Cell 1992)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. (PubMed id 19888660)1, 4 Andreotti G....Hsing A.W. (Eur. J. Epidemiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6257 HGNC: 10478 AceView: RXRB Ensembl:ENSG00000204231 euGenes: HUgn6257
    ECgene: RXRB Kegg: 6257 H-InvDB: RXRB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RXRB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RXRB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RXRB gene:
    Search GeneIP for patents involving RXRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RXRB
     
     EMD Millipore genomic analysis products

      
     Antibodies for RXRB (RXR beta/NR2B2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RXRB   OriGene RNAi products in human, mouse, rat for RXRB  
     OriGene qPCR primer pairs and template standards for RXRB   OriGene Protein Over-expression Lysate for RXRB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RXRB  
     OriGene qSTAR qPCR primer pairs in human, mouse for RXRB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RXRB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RXRB   OriGene Custom Protein Services for RXRB  

     
     
     Block miRNA regulation of human, mouse, rat RXRB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RXRB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RXRB Predesigned siRNA for gene silencing in human, mouse, rat RXRB
     QuantiFast Probe-based Assays in human, mouse, rat RXRB QuantiTect SYBR Green Assays in human, mouse, rat RXRB
     PCR Arrays including human, mouse, rat RXRB Search Chromatin IP Primers for RXRB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RXRB  GeneGlobe Interaction Network for RXRB
     Regulatory tfbs in RXRB promoter
     GenScript Custom Purified and Recombinant Proteins Services for RXRB GenScript cDNA clones with any tag delivered in your preferred vector for RXRB
     GenScript Custom Assay Services for RXRB GenScript Custom overexpressing Cell Line Services for RXRB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for RXRB 

     Tocris compounds for RXRB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for RXRB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RXRB antibodies
     RXRB proteins
     RXRB lysates
     Antibodies for RXRB
     See all of Abcam's Antibodies, Kits and Proteins for RXRB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for RXRB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB
     SwitchGear 3'UTR luciferase reporter plasmids for RXRB
     SwitchGear Promoter luciferase reporter plasmids for RXRB
     ThermoFisher Antibody for RXRB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB
     Browse compounds at ApexBio
     Search Addgene for plasmids for RXRB
      Search eBioscience for proteins for RXRB
      Search eBioscience for elisas for RXRB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RXRB
     antibodies-online antibodies for RXRB (58 products)
     antibodies-online kits for RXRB (8 products)
     antibodies-online peptides for RXRB
     antibodies-online proteins for RXRB (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RXRB gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4