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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RXRB Gene

protein-coding   GIFtS: 70
GCID: GC06M033161

Retinoid X Receptor, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Retinoid X Receptor, Beta1 2     RCoR-12
Nuclear Receptor Subfamily 2 Group B Member 21 2 3     MHC Class I Promoter Binding Protein2
NR2B22 3     Retinoic Acid Receptor RXR-Beta2
DAUDI62     Retinoid X Receptor Beta3
H-2RIIBP2     

External Ids:    HGNC: 104781   Entrez Gene: 62572   Ensembl: ENSG000002042317   OMIM: 1802465   UniProtKB: P287023   

Export aliases for RXRB gene to outside databases

Previous GC identifers: GC06M033164 GC06M033208 GC06M033270 GC06M032877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RXRB Gene:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in
mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid
hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective
response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome
6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Jul 2012)

GeneCards Summary for RXRB Gene: 
RXRB (retinoid X receptor, beta) is a protein-coding gene. Diseases associated with RXRB include x-linked adrenal hypoplasia congenita, and wegener's granulomatosis, and among its related super-pathways are Nuclear Receptors and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NR5A2.

UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA)

summary for RXRB Gene:
Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding
partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors
(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding
efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully
elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR
signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major
isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely
distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.

Gene Wiki entry for RXRB (Retinoid X receptor beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RXRB gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRXRB promoter sequence
   Search SABiosciences Chromatin IP Primers for RXRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RXRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RXRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXRB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033161:  view genomic region     (about GC identifiers)

Start:
33,161,365 bp from pter      End:
33,168,630 bp from pter
Size:
7,266 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_113891.2 4,605,201-4,612,266      Chr6-,NT_167245 4,442,672-4,449,739      Chr6-,NT_167247 4,635,129-4,642,193     
Chr6-,NT_167246 4,618,680-4,625,748      Chr6-,NT_167248 4,393,587-4,400,655     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702 (See protein sequence)
Recommended Name: Retinoic acid receptor RXR-beta  
Size: 533 amino acids; 56922 Da
Subunit: Homodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR
heterodimer
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RXRB:
1H9U (3D)        1UHL (3D)    
Secondary accessions: P28703 Q59G65 Q5JP92 Q5STQ1
Alternative splicing: 2 isoforms:  P28702-1   P28702-3   

Explore the universe of human proteins at neXtProt for RXRB: NX_P28702

Explore proteomics data for RXRB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28702

  • RXRB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RXRB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257330.1  NP_068811.1  

    ENSEMBL proteins: 
     ENSP00000363817   ENSP00000363812   ENSP00000431369   ENSP00000439222   ENSP00000415561  
    Reactome Protein details: P28702
    Human Recombinant Protein Products for RXRB: 
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    Enzo Life Sciences proteins for RXRB
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    OriGene Protein Over-expression Lysate for RXRB
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RXRB
    GenScript Custom Purified and Recombinant Proteins Services for RXRB
    Novus Biologicals RXRB Proteins
    Novus Biologicals RXRB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA7990953
    GO:0005654nucleoplasm TAS--

    RXRB for ontologies           About GeneDecksing



    RXRB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RXRB
    R&D Systems Antibodies for RXRB (RXR beta/NR2B2)
    Cell Signaling Technology (CST) Antibodies for RXRB 
    OriGene Antibodies for RXRB
    OriGene Custom Antibody Services for RXRB
    GenScript Custom Superior Antibodies Services for RXRB
    Novus Biologicals RXRB Antibodies
    Abcam antibodies for RXRB
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    LSBio Antibodies in human, mouse, rat for RXRB 

    Assay Products for RXRB: 
    EMD Millipore Kits and Assays for the Analysis of RXRB
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    GenScript Custom Assay Services for RXRB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Retinoid X receptor-&beta 
    2B. Retinoid X receptors

    5/6 InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR000003 Retinoid-X_rcpt/HNF4

    Graphical View of Domain Structure for InterPro Entry P28702

    ProtoNet protein and cluster: P28702

    2 Blocks protein domains:
    IPB000003 Retinoic acid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    RXRB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RXRB_HUMAN, P28702
    Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
    elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
    biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
    tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA)

         Genatlas biochemistry entry for RXRB:
    retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),beta subunit,obligate member
    of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1662118
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003713transcription coactivator activity TAS1662118
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA7990953
    GO:00048869-cis retinoic acid receptor activity IEA--
         
    RXRB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RXRB:
     G0/1 arrest  Increased G1 DNA content 

         15/18 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rxrb) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 

    RXRB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RXRB: Rxrbtm1Ipc Rxrbtm1Mma Rxrbtm1Rev

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RXRB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RXRB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RXRB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RXRB 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RXRB:
    hsa-mir-197 (MIRT004176), hsa-mir-346 (MIRT004235)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RXRB
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RXRB (see all 15):
    hsa-miR-520f hsa-miR-615-5p hsa-miR-627 hsa-miR-622 hsa-miR-324-3p hsa-miR-488 hsa-miR-144 hsa-miR-214*
    SwitchGear 3'UTR luciferase reporter plasmidRXRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of RXRB Gene knock-down
    OriGene RNAi products in human, mouse, rat for RXRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RXRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RXRB
    Sirion Biotech Customized adenovirus for overexpression of RXRB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RXRB (see all 7)
    OriGene ORF clones in mouse, rat for RXRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RXRB (NM_021976)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB
    Sirion Biotech Customized lentivirus for stable overexpression of RXRB 
                         Customized lentivirus expression plasmids for stable overexpression of RXRB 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RXRB
    Search LifeMap BioReagents cell lines for RXRB
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RXRB About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    2Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Nuclear Receptor Activation by Vitamin-A0.57
    3Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    4Glioma
    Non-small cell lung cancer0.51
    5Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RXRB
        Transcription Sin3 and NuRD in transcription regulation

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RXRB
        Nuclear Receptor Activation by Vitamin-A
    Oct4 in Mammalian ESC Pluripotency
    PPAR Pathway

    1 GeneGo (Thomson Reuters) Pathway for RXRB
        Transcription Sin3 and NuRD in transcription regulation

    2 BioSystems Pathways for RXRB
        Vitamin A and carotenoid metabolism
    Nuclear Receptors

    3        Reactome Pathways for RXRB
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression


    5/7         Kegg Pathways  (Kegg details for RXRB) (see all 7):
        PPAR signaling pathway
    Adipocytokine signaling pathway
    Pathways in cancer
    Transcriptional misregulation in cancer
    Thyroid cancer


    RXRB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RXRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/606 Interacting proteins for RXRB (P287021, 2, 3 ENSP000003638124) via UniProtKB, MINT, STRING, and/or I2D (see all 606)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1BQ009751, 3EBI-748576,EBI-1055161 I2D: score=1 
    HSP90B1P146252, 3MINT-7947479 I2D: score=1 
    NUDT21O438092, 3MINT-7947479 I2D: score=1 
    RARAP102762, 3, ENSP000002540664MINT-67313 I2D: score=5 STRING: ENSP00000254066
    SPOPO437912, 3, ENSP000002403274MINT-67766 I2D: score=5 STRING: ENSP00000240327
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001893maternal placenta development IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    RXRB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RXRB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RXRB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FluorobexaroteneRXR agonist[1190848-23-7]
    SR 11237Pan RXR agonist[146670-40-8]
    HX 531RXR antagonist[188844-34-0]
    UVI 3003RXR antagonist[847239-17-2]
    CD 3254Potent and selective RXRalpha agonist.[196961-43-0]

    2 HMDB Compounds for RXRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    9-cis-Retinoic acidTretinoin [usan:ban:inn] (see all 69)----
    Retinoic acidRetinoate (see all 21)302-79-4--

    10/11 DrugBank Compounds for RXRB (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bexarotene-- 153559-49-0targetagonist15632250 17483357 18765556 11702369 16495926 17008586 15897247 17139284 14700480 17016423 15056048
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8targetagonist18321241 19678713 17132853 16109390 17491551 16277658 16420438
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4targetagonist16392701 16109390 15379735 17184907 16420438
    AdapaleneAdapaleno [INN-Spanish] (see all 2)106685-40-9targetagonist10651997 17139284 17016423
    Tazarotene-- 118292-40-3targetagonist10828316 17139284 17016423
    6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid-- --target--17139284 17016423
    Acitretin-- 55079-83-9targetagonist17139284 17016423
    Etretinate-- 54350-48-0targetagonist17139284 17016423
    (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID-- --target--10592235
    N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE-- --target--10592235

    2 IUPHAR Ligands for RXRB (Retinoid X receptor-&beta)    About this table 
    LigandTypeActionAffinityPubmed IDs
    LG100754
    Antagonist811463859 11877384 8837780
    bexarotene
    AgonistAgonist7.710052980 10637371 8071941

    5 Novoseek inferred chemical compound relationships for RXRB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 75 23 1314168 (3), 8393143 (1), 7821715 (1), 10704832 (1) (see all 17)
    retinoid 70.9 9 12767074 (2), 10704832 (1), 15958702 (1), 9636132 (1)
    vitamin d 46.2 6 8389356 (1), 8631908 (1), 9717845 (1), 19811264 (1)
    oligonucleotide 0.95 1 15585599 (1)
    estrogen 0 4 8384307 (2), 7740175 (1)

    Search CenterWatch for drugs/clinical trials and news about RXRB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RXRB gene (2 alternative transcripts): 
    NM_001270401.1  NM_021976.4  

    Unigene Cluster for RXRB:

    Retinoid X receptor, beta
    Hs.388034  [show with all ESTs]
    Unigene Representative Sequence: NM_001270401
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374685(uc011dqr.2) ENST00000374680(uc003odb.3 uc003odc.3 uc011dqs.1)
    ENST00000483281 ENST00000483821 ENST00000481441(uc003ode.1) ENST00000544186
    ENST00000413614(uc011dqt.1 uc011dqu.1)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RXRB
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RXRB (see all 15):
    hsa-miR-520f hsa-miR-615-5p hsa-miR-627 hsa-miR-622 hsa-miR-324-3p hsa-miR-488 hsa-miR-144 hsa-miR-214*
    SwitchGear 3'UTR luciferase reporter plasmidRXRB 3' UTR sequence
    Inhib. RNA
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    EMD Millipore RNAi Products for the Analysis of RXRB Gene knock-down
    OriGene RNAi products in human, mouse, rat for RXRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RXRB
    Clone
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    OriGene clones in human, mouse for RXRB (see all 7)
    OriGene ORF clones in mouse, rat for RXRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RXRB (NM_021976)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB
    Sirion Biotech Customized lentivirus for stable overexpression of RXRB 
                         Customized lentivirus expression plasmids for stable overexpression of RXRB 
    Primer
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    OriGene qPCR primer pairs and template standards for RXRB
    OriGene qSTAR qPCR primer pairs in human, mouse for RXRB
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RXRB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RXRB

    Additional mRNA sequence: 

    AB209244.1 AK225842.1 AK302125.1 BC001167.1 BT007280.1 HQ692844.1 HQ709179.1 M84820.1 
    U00961.1 X63522.1 X65463.1 

    15 DOTS entries:

    DT.118619  DT.100811035  DT.91841173  DT.118621  DT.100798333  DT.100029702  DT.100811028  DT.448809 
    DT.95145990  DT.100798335  DT.75187712  DT.100767296  DT.100798340  DT.100830297  DT.121346999 

    24/297 AceView cDNA sequences (see all 297):

    BF875011 BE395926 AL047110 AU105238 AU099317 BQ063317 BM783602 CK903550 
    AA918367 AW026020 AI669725 BM014020 AI888632 NM_021976 AL044221 BX103701 
    BM999880 BI962866 AA348789 BM549884 BU542396 BG680532 BU726451 BE328430 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RXRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTGCCC
    RXRB Expression
    About this image


    See RXRB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RXRB

    SOURCE GeneReport for Unigene cluster: Hs.388034

    UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702
    Tissue specificity: Expressed in a variety of tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including RXRB: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RXRB gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxrb1 , 5 retinoid X receptor beta1, 5 91.6(n)1
    97.12(a)1
      17 (17.98 cM)5
    201821  NM_001205214.11  NP_001192143.11 
     340318125 
    lizard
    (Anolis carolinensis)
    Reptilia RXRB6
    retinoid X receptor, beta
    64(a)
    1 ↔ 1
    GL344340.1(6385-31434)
    African clawed frog
    (Xenopus laevis)
    Amphibia S73269.12   -- 77.7(n)    S73269.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131275.12   -- 81.01(n)   30530  NM_131275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta usp1 , 3 metamorphosis ecdysteroid hormone
    receptor3
    ultraspiracle1
    47(a)3
    59.18(n)1
    57.78(a)1
      2C73
    311651  NM_057433.31  NP_476781.11 


    ENSEMBL Gene Tree for RXRB (if available)
    TreeFam Gene Tree for RXRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RXRB gene
    NR5A22  RXRA2  RXRG2  NR2F12  NR5A12  NR2F22  NR2C12  HNF4G2  
    NR2F62  NR2E12  HNF4A2  NR2C22  NR6A12  
    18/46 SIMAP similar genes for RXRB using alignment to 6 protein entries:     RXRB_HUMAN (see all proteins) (see all similar genes):
    NR2B2    NR2C2    RXRA    NR2B3    RXRG    NR5A2
    NR2B1    HNF4alpha    PPARG    RORA    DKFZp779O0162    THRB
    HNF4G    NR2C1    NR2A3    NR3C2    ESR1    NR1I3

    RXRB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 SNPs in RXRB are shown (see all 205)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421491971,2
    --33081209(+) GGAGAC/GAGAGC 2 -- int10--------
    rs1511983601,2
    --33081281(+) AAGACC/GCCTGG 2 -- int10--------
    rs1404745831,2
    --33081452(+) TTGCAA/GCCCTC 4 G syn10--------
    rs1862328721,2
    C--33081489(+) CTACAC/GGGAAA 2 -- int10--------
    rs2006191151,2
    C,F--33081492(+) CAGGGA/TAAGGG 2 -- int11Minor allele frequency- T:0.01EU 875
    rs1500220091,2
    C--33081515(+) GAAGGC/TTGCAT 2 -- int10--------
    rs1914761141,2
    --33081522(+) GCATGG/TAGACA 2 -- int10--------
    rs178479331,2
    C,F--33081545(-) GGAAAC/GAGACT 2 -- int15Minor allele frequency- G:0.11CSA WA NA 243
    rs27445291,2
    C--33081569(-) TTTAAA/G/TTTTTG 2 -- int15MN 404
    rs27445281,2
    C--33081627(-) ACTGGA/G/TTCATC 2 -- int15MN 404

    HapMap Linkage Disequilibrium report for RXRB (33161365 - 33168630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RXRB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885768CNV Loss21882294
    nsv830634CNV Loss17160897
    nsv522719CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180246    OMIM disorders: --

    20/23 diseases for RXRB (see all 23):    About MalaCards
    x-linked adrenal hypoplasia congenita    wegener's granulomatosis    biliary tract cancer    vasculitis
    polycythemia vera    polycythemia    thyroiditis    alcohol dependence
    thyroid cancer    schizophrenia    coronary heart disease    alcoholism
    huntington's disease    psoriasis    type 1 diabetes    lung cancer
    systemic lupus erythematosus    lupus erythematosus    retinitis    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for RXRB:
    Wegener's granulomatosis

    RXRB for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for RXRB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wegeners granulomatosis 44.7 2 19811264 (1)
    vasculitis 25.7 2 19811264 (2)
    schizophrenia 0 2 11840500 (2)
    breast cancer 0 2 12767074 (1)
    tumors 0 2 8180126 (1)

    Genetic Association Database (GAD): RXRB
    Human Genome Epidemiology (HuGE) Navigator: RXRB (25 documents)

    Export disorders for RXRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RXRB gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with RXRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplas mic antibody associated vasculitis patients. (PubMed id 19811264)1, 4, 9 KAolsch A.I....Yard B.A. (2009)
    2. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (PubMed id 11840500)1, 4, 9 Ishiguro H....Arinami T. (2002)
    3. Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals. (PubMed id 8381386)1, 2, 9 Fleischhauer K.... Yang S.Y. (1993)
    4. Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. (PubMed id 1315958)1, 2, 9 Fleischhauer K....Yang S.Y. (1992)
    5. Mapping of RXRB to human chromosome 6p21.3. (PubMed id 8257090)1, 3, 9 Fitzgibbon J....Povey S. (1993)
    6. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. (PubMed id 1310259)1, 2, 9 Leid M....Chambon P. (1992)
    7. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    10. Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. (PubMed id 19888660)1, 4 Andreotti G....Hsing A.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6257 HGNC: 10478 AceView: RXRB Ensembl:ENSG00000204231 euGenes: HUgn6257
    ECgene: RXRB Kegg: 6257 H-InvDB: RXRB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RXRB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RXRB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RXRB gene:
    Search GeneIP for patents involving RXRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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