RXRB Gene
protein-coding GIFtS: 68
GCID: GC06M033161
|
|
retinoid X receptor, beta
| |
Aliases
for RXRB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinoid X Receptor, Beta1 2 | | DAUDI62 | | NR2B21 2 3 | | MHC Class I Promoter Binding Protein2 | | H-2RIIBP1 2 | | Retinoic Acid Receptor RXR-Beta2 | | RCoR-11 2 | | Retinoid X Receptor Beta3 | | Nuclear Receptor Subfamily 2 Group B Member 22 3 | | |
Export aliases for RXRB gene to outside databasesPrevious GC identifers: GC06M033164 GC06M033208 GC06M033270 GC06M032877 |
Summaries
for RXRB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RXRB:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediatingthe effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, andvitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements.This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternativelyspliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul2012)
UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements inresponse to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biologicalprocesses. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3'sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA)
 summary
for RXRB: Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding
partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors
(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding
efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully
elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR
signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major
isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely
distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.
Gene Wiki entry for RXRB (Retinoid X receptor beta)
|
Genomic Views
for RXRB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RXRB gene promoter:
Sp1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RXRB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RXRB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3RXRB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M033161: view genomic region
(about GC identifiers)
Start:
|
33,161,365 bp from pter |
End:
|
33,168,630 bp from pter |
Size:
|
7,266 bases |
Orientation:
|
minus strand |
5 alternative locations:
| Chr6-,ALT_REF_LOCI_4 33,238,339-33,245,407 | Chr6-,ALT_REF_LOCI_3 33,139,275-33,157,380 | Chr6-,ALT_REF_LOCI_5 33,246,552-33,253,616 | | Chr6-,ALT_REF_LOCI_2 33,082,997-33,129,250 | Chr6-,ALT_REF_LOCI_6 33,090,190-33,132,839 |
|
Proteins
for RXRB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702 (See
protein sequence)Recommended Name: Retinoic acid receptor RXR-beta Size: 533 amino acids; 56922 Da
Subunit: Homodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for RXRB:1H9U (3D)
1UHL (3D)
Secondary accessions: P28703 Q59G65 Q5JP92 Q5STQ1Alternative splicing: 2 isoforms: P28702-1 P28702-3 Explore the universe of human proteins at neXtProt for RXRB: NX_P28702
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P28702
RXRB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001257330.1 NP_068811.1
ENSEMBL proteins: ENSP00000363817 ENSP00000363812 ENSP00000431369 ENSP00000439222 ENSP00000415561 Reactome Protein details: P28702
Human Recombinant Protein Products for RXRB:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RXRB for ontologies About GeneDecksing
RXRB Antibody Products:
Assay Products for RXRB: |
Protein
Domains /
Families
for RXRB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RXRB for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P28702ProtoNet protein and cluster: P28702 2 Blocks protein families: IPB000003 Retinoic acid receptor signature IPB001723 Steroid hormone receptor signature
UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-bindingdomainSimilarity: Belongs to the nuclear hormone receptor family. NR2 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for RXRB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RXRB_HUMAN, P28702Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements inresponse to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biologicalprocesses. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3'sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA) Genatlas biochemistry entry for RXRB:retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),beta subunit,obligate member ofheterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily
Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | 1662118 | | GO:0003707 | steroid hormone receptor activity |
IEA | -- | | GO:0003713 | transcription coactivator activity |
TAS | 1662118 | | GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
IDA | 7990953 | | GO:0004886 | 9-cis retinoic acid receptor activity |
IEA | -- |
RXRB for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for RXRB:
15/18 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Rxrb) (see all 18):
RXRB for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for RXRB: Rxrbtm1Ipc Rxrbtm1Mma Rxrbtm1Rev
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RXRB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RXRB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RXRB (NM_021976) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RXRB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB |
|
Pathways & Interactions
for RXRB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Sin3 and NuRD in transcription regulation | | | 2 | Nuclear Receptor transcription pathway | | | 3 | Generic Transcription Pathway | | | 4 | Apoptotic Pathways in Synovial Fibroblasts | | | 5 | Oct4 in Mammalian ESC Pluripotency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RXRB
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RXRB
1  GeneGo (Thomson Reuters) Pathway for RXRB
2  BioSystems Pathways for RXRB
3 
Reactome Pathways for RXRB
5/6 
Kegg Pathways (Kegg details for RXRB) (see all 6):
RXRB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RXRB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/584 Interacting proteins for RXRB (P287021, 2, 3 ENSP000003638124) via UniProtKB, MINT, STRING, and/or I2D (see all 584)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0001893 | maternal placenta development |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- |
RXRB for ontologies About GeneDecksing
|
Drugs & Compounds
for RXRB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RXRB for compounds About GeneDecksing
Compounds for RXRB available from Tocris Bioscience About this table
2 HMDB Compounds for RXRB About this table
10/11 DrugBank Compounds for RXRB (see all 11) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Bexarotene | -- | 153559-49-0 | target | agonist | 15632250 17483357 18765556 11702369 16495926 17008586 15897247 17139284 14700480 17016423 15056048 | | Alitretinoin | 9-cis-Retinoic acid (see all 4) | 5300-03-8 | target | agonist | 18321241 19678713 17132853 16109390 17491551 16277658 16420438 | | Tretinoin | All Trans Retinoic Acid (see all 5) | 302-79-4 | target | agonist | 16392701 16109390 15379735 17184907 16420438 | | Adapalene | Adapaleno [INN-Spanish] (see all 2) | 106685-40-9 | target | agonist | 10651997 17139284 17016423 | | Tazarotene | -- | 118292-40-3 | target | agonist | 10828316 17139284 17016423 | | 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid | -- | -- | target | -- | 17139284 17016423 | | Acitretin | -- | 55079-83-9 | target | agonist | 17139284 17016423 | | Etretinate | -- | 54350-48-0 | target | agonist | 17139284 17016423 | | (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID | -- | -- | target | -- | 10592235 | | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | -- | -- | target | -- | 10592235 |
5 Novoseek chemical compound relationships for RXRB gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoic acid |
75 |
23 |
1314168 (3), 8393143 (1), 7821715 (1), 10704832 (1) (see all 17) |
| retinoid |
70.9 |
9 |
12767074 (2), 10704832 (1), 15958702 (1), 9636132 (1) |
| vitamin d |
46.2 |
6 |
8389356 (1), 8631908 (1), 9717845 (1), 19811264 (1) |
| oligonucleotide |
0.95 |
1 |
15585599 (1) |
| estrogen |
0 |
4 |
8384307 (2), 7740175 (1) |
Search CenterWatch for drugs/clinical trials and news about RXRB
|
Transcripts
for RXRB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RXRB gene (2 alternative transcripts): NM_001270401.1 NM_021976.4 Unigene Cluster for RXRB: Retinoid X receptor, beta Hs.388034 [show with all ESTs]Unigene Representative Sequence: NM_0012704017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374685(uc011dqr.2) ENST00000374680(uc003odb.3 uc003odc.3 uc011dqs.1)
ENST00000483281 ENST00000483821 ENST00000481441(uc003ode.1) ENST00000544186
ENST00000413614(uc011dqt.1 uc011dqu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RXRB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RXRB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RXRB (NM_021976) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RXRB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB |
Additional cDNA sequence: AB209244.1 AK225842.1 AK302125.1 BC001167.1 BT007280.1 HQ692844.1 HQ709179.1 M84820.1 U00961.1 X63522.1 X65463.1 16 DOTS entries: DT.118619 DT.100811035 DT.91841173 DT.118621 DT.100798333 DT.100029702 DT.100811028 DT.100830297 DT.448809 DT.95145990 DT.100798335 DT.75187712 DT.100767296 DT.100798340 DT.121346999 DT.91753672 24/297 AceView cDNA sequences (see all 297): BX103701 AI669725 NM_021976 AL044221 BG680532 BU726451 BM014020 AA336809 AI888632 AW008891 CR618812 BM783602 BM999880 AI608692 AI003461 BF875016 BI962952 AA195311 F13008 BI906740 BF875011 AU105238 BI962866 AU099317
GeneLoc Exon Structure
|
Expression
for RXRB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RXRB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTTGCCC
About this image
See RXRB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RXRB
SOURCE GeneReport for Unigene cluster: Hs.388034
UniProtKB/Swiss-Prot: RXRB_HUMAN, P28702Tissue specificity: Expressed in a variety of tumor cell lines
SABiosciences Expression via Pathway-Focused PCR Arrays including RXRB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RXRB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RXRB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RXRB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RXRB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB |
Orthologs
for RXRB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RXRB gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
S73269.12 |
-- |
77.7(n) |
|
S73269.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
NM_131275.12 |
-- |
81.01(n) |
|
30530 NM_131275.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
usp1 , 3 |
metamorphosis ecdysteroid hormone receptor3
ultraspiracle1 |
47(a)3
59.18(n)1
57.78(a)1 |
|
2C73
311651 NM_057433.31 NP_476781.11 |
ENSEMBL Gene Tree for RXRB (if available)
TreeFam Gene Tree for RXRB (if available) |
Paralogs
for RXRB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RXRB gene
- ESRRA2 RXRG2 PGR2 ESR22 ESRRB2 HNF4G2 NR2F62 NR2E12
- ESRRG2 NR3C22 RXRA2 NR2F12 NR3C12 NR2F22 AR2 ESR12
- NR2C12 HNF4A2 NR2C22
18/50 SIMAP similar genes for RXRB using alignment to 9 protein entries: RXRB_HUMAN (see all proteins)
(see all similar genes):NR2B2 NR2C2 RXRA NR2B3 RXRG NR2B1
HNF4alpha PPARG RORA DKFZp779O0162 THRB PPARA
NR2C1 HNF4G NR2A3 NR3C2 NR1I3 VDR
RXRB for paralogs About GeneDecksing
|
Genomic Variants
for RXRB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RXRB (33161365 - 33168630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RXRB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RXRB |
|
Disorders
/ Diseases
for RXRB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RXRB for disorders About GeneDecksing
OMIM gene information: 180246
OMIM disorders: --
20/26  diseases for RXRB (see all 26): About MalaCardsx-linked adrenal hypoplasia congenita wegener's granulomatosis adrenal hypoplasia thyroiditis
polycythemia vera biliary tract cancer systemic lupus erythematosus lupus erythematosus
coronary heart disease alcohol dependence polycythemia vasculitis
huntington's disease lung cancer endometrial cancer pulmonary disease
alcoholism schizophrenia thyroid cancer psoriasis
1 disease from the University of Copenhagen DISEASES database for RXRB:Wegener's granulomatosis 5 Novoseek disease relationships for RXRB gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| wegeners granulomatosis |
44.7 |
2 |
19811264 (1) |
| vasculitis |
25.7 |
2 |
19811264 (2) |
| schizophrenia |
0 |
2 |
11840500 (2) |
| breast cancer |
0 |
2 |
12767074 (1) |
| tumors |
0 |
2 |
8180126 (1) |
Genetic Association Database (GAD): RXRB
Human Genome Epidemiology (HuGE) Navigator: RXRB (25 documents)
Export disorders for RXRB gene to outside databases
|
Publications
for RXRB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RXRB gene, integrated from 9 sources (see all 143):
(articles sorted by number of sources associating them with RXRB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (PubMed id 11840500)1, 4, 9 Ishiguro H....Arinami T. (2002)
- Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals. (PubMed id 8381386)1, 2, 9 Fleischhauer K.... Yang S.Y. (1993)
- Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. (PubMed id 1315958)1, 2, 9 Fleischhauer K....Yang S.Y. (1992)
- Mapping of RXRB to human chromosome 6p21.3. (PubMed id 8257090)1, 3, 9 Fitzgibbon J....Povey S. (1993)
- Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. (PubMed id 1310259)1, 2, 9 Leid M....Chambon P. (1992)
- Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)1, 4 Feng J....Sommer S.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The structural basis for the specificity of retinoid-X receptor- selective agonists: new insights into the role of helix H12. (PubMed id 11782480)1, 2 Love J.D.... Schwabe J.W. (2002)
- Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes. (PubMed id 12175732)1, 9 Rajsbaum R....Awdeh Z.L. (2002)
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External Searches for RXRB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RXRB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RXRB gene
(According to HUGE)
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Specialized Databases showing RXRB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RXRB gene:
Search GeneIP for patents involving RXRB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RXRB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for RXRB | | OriGene shRNA RFP for RXRB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RXRB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RXRB | | | OriGene Protein Over-expression Lysate for RXRB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RXRB | | OriGene 3'-UTR Clone for RXRB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RXRB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RXRB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RXRB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RXRB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RXRB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RXRB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RXRB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RXRB |
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| | Antibodies & Assays for RXRB |
| | | | Tocris compounds for RXRB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRB |
|  |  |  |  | | | | ThermoFisher Antibody for RXRB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXRB |
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