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Aliases for RXRB Gene

Aliases for RXRB Gene

  • Retinoid X Receptor Beta 2 3 4 5
  • Nuclear Receptor Subfamily 2 Group B Member 2 2 3 4
  • NR2B2 3 4
  • MHC Class I Promoter Binding Protein 3
  • Retinoic Acid Receptor RXR-Beta 3
  • Retinoid X Receptor, Beta 2
  • H-2RIIBP 3
  • DAUDI6 3
  • RCoR-1 3

External Ids for RXRB Gene

Previous GeneCards Identifiers for RXRB Gene

  • GC06M033164
  • GC06M033208
  • GC06M033270
  • GC06M033161
  • GC06M032877

Summaries for RXRB Gene

Entrez Gene Summary for RXRB Gene

  • This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for RXRB Gene

RXRB (Retinoid X Receptor Beta) is a Protein Coding gene. Diseases associated with RXRB include Wegener Granulomatosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot for RXRB Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Tocris Summary for RXRB Gene

  • Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.

Gene Wiki entry for RXRB Gene

Additional gene information for RXRB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXRB Gene

Genomics for RXRB Gene

GeneHancer (GH) Regulatory Elements for RXRB Gene

Promoters and enhancers for RXRB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033198 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566.5 -0.1 -148 4 MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 RXRB RNY4P10 SLC39A7 GC06P033199 DAXX BRD2 WDR46 RGL2 LEMD2 RPS18
GH06I032965 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 152.5 +230.2 230184 10.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 BRD2 HLA-DMA ENSG00000223837 LEMD2 VPS52 RXRB ATF6B DAXX HCG25 RING1
GH06I033270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 63.4 -74.3 -74276 8.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RPS18 VPS52 B3GALT4 PIR43330 BRD2 LEMD2 DAXX RXRB RING1 WDR46
GH06I033203 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 47.3 -5.6 -5550 5.8 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RING1 HSD17B8 MIR219A1 GC06P033209 BRD2 LEMD2 VPS52 RXRB HCG25 DAXX
GH06I033390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41.9 -191.8 -191792 4.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 KIFC1 DAXX BRD2 LEMD2 RXRB RGL2 WDR46 VPS52 RPS18 HLA-DOB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RXRB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RXRB gene promoter:

Genomic Locations for RXRB Gene

Genomic Locations for RXRB Gene
chr6:33,193,585-33,200,853
(GRCh38/hg38)
Size:
7,269 bases
Orientation:
Minus strand
chr6:33,161,365-33,168,630
(GRCh37/hg19)

Genomic View for RXRB Gene

Genes around RXRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RXRB Gene

  • Protein details for RXRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28702-RXRB_HUMAN
    Recommended name:
    Retinoic acid receptor RXR-beta
    Protein Accession:
    P28702
    Secondary Accessions:
    • P28703
    • Q59G65
    • Q5JP92
    • Q5STQ1

    Protein attributes for RXRB Gene

    Size:
    533 amino acids
    Molecular mass:
    56922 Da
    Quaternary structure:
    • Homodimer (in vitro) (PubMed:11782480). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:1310259). Interacts with NR1H3 (PubMed:12970175). Interacts with AKAP13 (By similarity).
    SequenceCaution:
    • Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RXRB Gene

    Alternative splice isoforms for RXRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RXRB Gene

Post-translational modifications for RXRB Gene

Other Protein References for RXRB Gene

No data available for DME Specific Peptides for RXRB Gene

Domains & Families for RXRB Gene

Gene Families for RXRB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P28702

UniProtKB/Swiss-Prot:

RXRB_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with RXRB: view

Function for RXRB Gene

Molecular function for RXRB Gene

GENATLAS Biochemistry:
retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),beta subunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Phenotypes From GWAS Catalog for RXRB Gene

Gene Ontology (GO) - Molecular Function for RXRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 12767074
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 12767074
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 1662118
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with RXRB: view
genes like me logo Genes that share phenotypes with RXRB: view

Animal Models for RXRB Gene

MGI Knock Outs for RXRB:

Clone Products

  • Addgene plasmids for RXRB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXRB Gene

Localization for RXRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXRB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RXRB gene
Compartment Confidence
nucleus 5
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RXRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 7990953
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RXRB: view

Pathways & Interactions for RXRB Gene

genes like me logo Genes that share pathways with RXRB: view

SIGNOR curated interactions for RXRB Gene

Gene Ontology (GO) - Biological Process for RXRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030522 intracellular receptor signaling pathway IEA --
GO:0043401 steroid hormone mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with RXRB: view

Drugs & Compounds for RXRB Gene

(29) Drugs for RXRB Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bexarotene Approved, Investigational Pharma Agonist, Target, agonist Potent and selective RXR agonist, Others 44
Adapalene Approved Pharma Target, agonist, binder RAR尾 and RAR纬 agonist 78
Tazarotene Approved, Investigational Pharma Target, agonist, binder Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 46
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 30
Alitretinoin Approved, Investigational Pharma Target, agonist 17

(5) Additional Compounds for RXRB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
9-cis-retinoic acid
  • 15-Apo-beta-caroten-15-oate
  • 15-Apo-beta-caroten-15-oic acid
  • 9-cis-Retinoate
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
Agonist
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
Full agonist, Agonist 302-79-4

(4) Tocris Compounds for RXRB Gene

Compound Action Cas Number
Bexarotene Potent and selective RXR agonist 153559-49-0
CD 3254 Potent and selective RXRalpha agonist. 196961-43-0
HX 531 Potent RXR antagonist 188844-34-0
LG 100754 RXR:PPAR agonist 180713-37-5

(11) ApexBio Compounds for RXRB Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Bexarotene 153559-49-0
Fluorobexarotene 1190848-23-7
HX 531 188844-34-0
HX 630 188844-52-2
LG 100754 180713-37-5
LG 101506 331248-11-4
PA 452 457657-34-0
SR 11237 146670-40-8
UVI 3003 847239-17-2
genes like me logo Genes that share compounds with RXRB: view

Drug Products

Transcripts for RXRB Gene

Unigene Clusters for RXRB Gene

Retinoid X receptor, beta:
Representative Sequences:

Clone Products

  • Addgene plasmids for RXRB

Alternative Splicing Database (ASD) splice patterns (SP) for RXRB Gene

No ASD Table

Relevant External Links for RXRB Gene

GeneLoc Exon Structure for
RXRB
ECgene alternative splicing isoforms for
RXRB

Expression for RXRB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RXRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RXRB Gene

This gene is overexpressed in Blymphocyte (27.3), Peripheral blood mononuclear cells (12.2), Placenta (10.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RXRB Gene



Protein tissue co-expression partners for RXRB Gene

NURSA nuclear receptor signaling pathways regulating expression of RXRB Gene:

RXRB

SOURCE GeneReport for Unigene cluster for RXRB Gene:

Hs.388034

mRNA Expression by UniProt/SwissProt for RXRB Gene:

P28702-RXRB_HUMAN
Tissue specificity: Expressed in a variety of tumor cell lines.

Evidence on tissue expression from TISSUES for RXRB Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with RXRB: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXRB Gene

Orthologs for RXRB Gene

This gene was present in the common ancestor of animals.

Orthologs for RXRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXRB 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia RXRB 33 34
  • 95.21 (n)
cow
(Bos Taurus)
Mammalia RXRB 33 34
  • 93.11 (n)
oppossum
(Monodelphis domestica)
Mammalia RXRB 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxrb 33 16 34
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Rxrb 33
  • 90.35 (n)
lizard
(Anolis carolinensis)
Reptilia RXRB 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rxrb 33
  • 73.24 (n)
zebrafish
(Danio rerio)
Actinopterygii rxrba 33 34
  • 73.12 (n)
rxrbb 34
  • 70 (a)
OneToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta usp 35 34
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-69 35
  • 34 (a)
nhr-14 35
  • 33 (a)
Species where no ortholog for RXRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RXRB Gene

ENSEMBL:
Gene Tree for RXRB (if available)
TreeFam:
Gene Tree for RXRB (if available)

Paralogs for RXRB Gene

Variants for RXRB Gene

Sequence variations from dbSNP and Humsavar for RXRB Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000491541 -- 33,194,538(-) G/C 3_prime_UTR_variant
rs1000612226 -- 33,194,223(-) A/G 3_prime_UTR_variant
rs1001539000 -- 33,195,886(-) A/G intron_variant
rs1001951266 -- 33,201,835(-) C/G upstream_transcript_variant
rs1002841616 -- 33,200,610(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RXRB Gene

Variant ID Type Subtype PubMed ID
dgv10609n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv522719 CNV loss 19592680
nsv830634 CNV loss 17160897

Variation tolerance for RXRB Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RXRB Gene

Human Gene Mutation Database (HGMD)
RXRB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RXRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXRB Gene

Disorders for RXRB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RXRB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wegener granulomatosis
  • wg
- elite association - COSMIC cancer census association via MalaCards
Search RXRB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RXRB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RXRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RXRB Gene

Publications for RXRB Gene

  1. Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patients. (PMID: 19811264) Kälsch AI … Yard BA (Autoimmunity 2009) 3 22 44 58
  2. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (PMID: 11840500) Ishiguro H … Arinami T (American journal of medical genetics 2002) 3 22 44 58
  3. Mapping of RXRB to human chromosome 6p21.3. (PMID: 8257090) Fitzgibbon J … Povey S (Annals of human genetics 1993) 2 3 22 58
  4. Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals. (PMID: 8381386) Fleischhauer K … Yang SY (Human genetics 1993) 3 4 22 58
  5. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. (PMID: 1310259) Leid M … Mader S (Cell 1992) 3 4 22 58

Products for RXRB Gene