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RXRA Gene

protein-coding GIFtS: 67

GC09P137208

retinoid X receptor, alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
retinoid X receptor, alpha¹ ²		FLJ00318²
NR2B1¹ ² ³		retinoic acid receptor RXR-alpha²
Nuclear receptor subfamily 2 group B member 1² ³		FLJ16733²
MGC102720²		FLJ00280²
FLJ16020²		Retinoid X receptor alpha³

External Ids:	HGNC: 10477¹	Entrez Gene: 6256²	Ensembl: ENSG00000186350⁷	UniProtKB: P19793³

Search outside databases for aliases for RXRA gene

Previous GC identifers: GC09P128442 GC09P129062 GC09P130816 GC09P132732 GC09P132661 GC09P134519 GC09P136358

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RXRA:

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological

effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their

action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and

regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone

receptor superfamily of transcriptional regulators. (provided by RefSeq)

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Function: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).

ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity)

summary for RXRA:

Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding

partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors

(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding

efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully

elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR

signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major

isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely

distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.

Gene Wiki entry for RXRA (Retinoid X receptor alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RXRA gene upstream (promoter) region

:
AP-1 FOXO1a AhR GR-alpha p300 GR-beta c-Jun c-Fos Sox9 GATA-2

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for RXRA:

MePH13198-1A MePH13201-1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34

RXRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P137208: view genomic region (about GC identifiers)

Start:	137,208,944 bp from pter
End:	137,332,431 bp from pter
Size:	123,488 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.11 NT_019501.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 (See protein sequence)

Recommended Name: Retinoic acid receptor RXR-alpha

Size: 462 amino acids; 50811 Da

Subunit: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called

adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong

increase of transcription of target genes. Interacts with FAM120B (By similarity). Interacts with SFPQ. Interacts with

HCV core protein. Interacts with PELP1. Interacts with SENP6. Interacts with DNTTIP2. Interacts with RNF8

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1BY4 (3D)

1DSZ (3D)

1FBY (3D)

1FM6 (3D)

1FM9 (3D)

1G1U (3D)

1G5Y (3D)

1K74 (3D)

1LBD (3D)

1MV9 (3D)

1MVC (3D)

1MZN (3D)

1R0N (3D)

1RDT (3D)

1RXR (3D)

1XLS (3D)

1XV9 (3D)

1XVP (3D)

1YNW (3D)

2ACL (3D)

2NLL (3D)

2P1T (3D)

2P1U (3D)

2P1V (3D)

2ZXZ (3D)

2ZY0 (3D)

3DZU (3D)

3DZY (3D)

3E00 (3D)

3E94 (3D)

3FAL (3D)

3FC6 (3D)

3FUG (3D)

3H0A (3D)

3KWY (3D)

Secondary accessions: Q2V504

Post-translational modifications:

Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002948.1

ENSEMBL proteins:

ENSP00000419692

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	HuPro® and/or Recombinant Proteins from Abnova for RXRA
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for RXRA
	Novus Biologicals Lysate for RXRA
	Browse Sino Biological Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	7990953
GO:0030424	axon	IEA	--

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RXRA for ontologies About GeneDecksing

Antibodies for RXRA:

	Millipore Mono- and Polyclonal Antibodies for the study of RXRA
	Sigma-Aldrich Antibodies for RXRA
	R&D Systems Antibodies for RXRA (RXR alpha/NR2B1)
	Monoclonal and Polyclonal Antibodies from Abnova (RXRA)
	Origene Antibodies: RXRA
	Novus Biologicals Antibodies for RXRA
	Browse antibodies at Epitomics

Assays for RXRA:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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RXRA for domains About GeneDecksing

5 InterPro domains/families:

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

IPR001628 Znf_hrmn_rcpt

IPR021780 DUF3345

IPR001723 Str_hrmn_rcpt

Graphical View of Domain Structure for InterPro Entry P19793

ProtoNet protein and cluster: P19793

2 Blocks protein families:

IPB000003 Retinoic acid receptor signature

IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal

steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RXRA)
		Origene 29mer shRNA kits in GFP-retroviral vector: RXRA Origene shRNA RFP: RXRA Origene basic RS shRNA: RXRA
		Applied Biosystems Silencer® siRNAs for RXRA
		Sigma-Aldrich siRNA Panels and siRNA for RXRA Sigma-Aldrich shRNA Panels and shRNA for RXRA Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: RXRA Origene Myc/DDK tagged cDNA clones in CMV expression vector: RXRA Origene untagged cDNA clones in CMV expression vector: RXRA
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Function: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).

ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity)

Genatlas biochemistry entry for RXRA:

retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),alpha subunit,regulating cardiac

morphogenesis,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

5/15 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	12037571
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	contributes to transcription factor activity	IDA	17426122
GO:0003706	ligand-regulated transcription factor activity	IDA	7990953
GO:0003707	steroid hormone receptor activity	IEA	--

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RXRA for ontologies About GeneDecksing

Animal Models: 15/26 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Rxra) (see all 26 ):

behavior/neurological	cardiovascular system	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system

RXRA for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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RXRA for pathways About GeneDecksing

5 Millipore Pathways for RXRA

	Transcription PPAR Pathway
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Development Beta-adrenergic receptors signaling via cAMP
	Transcription Sin3 and NuRD in transcription regulation
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

5/17 Sigma-Aldrich "Your Favorite Gene" Pathways for RXRA (Your Favorite Gene powered by Ingenuity) (see all 17 )

	Thyroid Cancer Signaling
	FXR/RXR Activation
	Xenobiotic Metabolism Signaling
	Hepatic Cholestasis
	PPAR?/RXR? Activation

4 GeneAssist Pathways for RXRA

	Nuclear Receptor Activation by Vitamin-A
	Nur77 Signaling in T-Cell
	PPAR Pathway
	RAR-Gamma-RXR-Alpha Degradation

5/6 Kegg Pathways (Kegg details for RXRA) (see all 6 ):

	hsa03320 PPAR signaling pathway
	hsa04920 Adipocytokine signaling pathway
	hsa05200 Pathways in cancer
	hsa05216 Thyroid cancer
	hsa05222 Small cell lung cancer

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RXRA

5/14 Interacting proteins for RXRA (P19793^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDF1	O60869¹	EBI-78598,EBI-781301
PRMT2	P55345¹	EBI-78598,EBI-78458
MED25	Q71SY5²	MINT-5210379 MINT-5210002 MINT-5210351 MINT-5210362
LOC100131261	Q9NPJ4²	MINT-14590
NCOA1	Q15788²	MINT-5224970

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5/31 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 31 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001889	liver development	IEA	--
GO:0001890	placenta development	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006766	vitamin metabolic process	TAS	1651173
GO:0006954	inflammatory response	IEA	--

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RXRA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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RXRA for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for RXRA

Sigma-Aldrich Small Molecules for RXRA:

Small Molecule - Antagonist Small Molecule - Ligand Small Molecule - Activator

Compounds for RXRA available from Tocris Bioscience

Compound	Action	CAS number
Liarozole hydrochloride	Blocks retinoic acid metabolism	[145858-50-0]
Docosahexaenoic acid	Selective RXR agonist	[6217-54-5]
Fenretinide	Synthetic retinoid. Potent anti-cancer agent	[65646-68-6]
SR 11237	Pan RXR agonist	[146670-40-8]
Retinoic acid	Endogenous retinoic acid receptor agonist. Also modulates PPARdelta	[302-79-4]

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10/117 Novoseek chemical compound relationships for RXRA gene (see all 117 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoid	100.00	95	16782282 (4), 15082790 (4), 9417874 (3), 12746291 (3) (see all 69)
retinoic acid	100.00	189	18082883 (5), 8631847 (4), 16782282 (4), 12054477 (4) (see all 100)
vitamin d	25.57	40	10692108 (4), 20049159 (3), 17707062 (3), 12365798 (3) (see all 28)
androstane	14.41	8	19480556 (1), 17932222 (1), 17276571 (1), 16971569 (1) (see all 8)
acyclic retinoid	10.47	5	19520494 (2), 7519016 (1), 15010815 (1), 11779708 (1)
bexarotene	9.64	6	12006543 (2), 10377179 (2), 18003614 (1), 11121228 (1)
rosiglitazone	7.16	9	17107731 (4), 18031620 (2), 9492033 (1), 15715931 (1) (see all 5)
wy14643	7.04	4	10866995 (4)
acitretin	6.35	5	18575340 (5)
troglitazone	3.94	5	14522385 (1), 12941612 (1), 12851681 (1), 10935488 (1) (see all 5)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RXRA)
		Applied Biosystems Silencer® siRNAs: NM_002957
		Origene 29mer shRNA kits in GFP-retroviral vector: RXRA Origene shRNA RFP: RXRA Origene basic RS shRNA: RXRA
		Sigma-Aldrich siRNA Panels and siRNA for RXRA Sigma-Aldrich shRNA Panels and shRNA for RXRA Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		10/16 SABiosciences microRNAs that regulate RXRA (see all 16 ):
		hsa-miR-128b hsa-miR-148b hsa-miR-27a hsa-miR-128 hsa-miR-301a hsa-miR-152 hsa-miR-124 hsa-miR-9 hsa-miR-19b hsa-miR-454

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_002957

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: RXRA
Origene Myc/DDK tagged cDNA clones in CMV expression vector: RXRA
Origene untagged cDNA clones in CMV expression vector: RXRA

Primers:		Origene genome-wide validated SYBR primer pairs: RXRA
		SABiosciences RT2 qPCR Primer Assay for RXRA: PPH01244A

REFSEQ mRNAs for RXRA gene:

NM_002957.4

Additional cDNA sequence:

AB307705.1 AF052092.1 AK131081.1 AK131513.1 BC007925.1 BC009882.2 BC031356.1 BC063827.1

BC096246.2 BC110998.1 CR593545.1 U66306.1 X52773.1

9 DOTS entries:

DT.116413 DT.102827176 DT.91709154 DT.100785446 DT.100785440 DT.75120807 DT.95338039 DT.121164592

DT.121164622

24/320 AceView cDNA sequences (see all 320 ):

BM563384 BM716677 BU684863 AI539418 BM701589 BU626526 CF551993 AI739398

BG315238 BM562776 CD518702 CA393592 F31386 AA642263 AI934852 CA430473

BU192986 CA393601 AA682398 AI061249 AI312941 W86756 BQ637881 BU687848

highest scoring ESTs for RXRA:

U66306 X52773 AA004312 AA156826 AA203686 AA236526 AA351572 AA464615 AA492475 AA514484

Unigene Cluster for RXRA:

Retinoid X receptor, alpha

Hs.590886 [show with all ESTs]

Unigene Representative Sequence: AK131081

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RXRA

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b
SP1:													-
SP2:							-		-		-		-		-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for RXRA

3 Ensembl transcripts including schematic representations:

ENST00000356384 ENST00000481739 ENST00000484822

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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RXRA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RXRA

¹ / ² / ³

6 probe-sets matching RXRA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
405_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.70	X52773	1.00	1.00	1.00	1
32800_at²^{, 3}	U95-A	1	0.94	1.00	0.91	1.31	U66306	1.00	1.00	1.00	1
202426_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE675800	0.80	1.00	0.91	1
202449_s_at²^{, 3}	U133-A	1	0.82	1.00	--	--	NM_002957	0.60	1.00	0.82	1
202426_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202449_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

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RXRA for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TATGTGCTGT

SOURCE GeneReport for Unigene cluster: Hs.590886

Expression variation in blood from EXPOLDB for RXRA

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Tissue specificity: Highly expressed in liver, also found in lung, kidney and heart

Primers:		Origene genome-wide validated SYBR primer pairs: RXRA
		SABiosciences RT2 qPCR Primer Assay for RXRA: PPH01244A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RXRA gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RXRA¹	--	retinoid X receptor, alpha	92.07(n) 98.72(a)	491278 XM_548399.2 XP_548399.2
chimpanzee (Pan troglodytes)	RXRA¹	--	retinoid X receptor, alpha	99.41(n) 99.56(a)	464834 XM_520345.2 XP_520345.2
cow (Bos taurus)	RXRA¹	--	retinoid X receptor, alpha	92.57(n) 97.79(a)	507554 XM_881943.2 XP_887036.2
rat (Rattus norvegicus)	Rxra¹	--	retinoid X receptor alpha	89.39(n) 98.48(a)	25271 NM_012805.1 NP_036937.1
mouse (Mus musculus)	Rxra^{1, 5}	2 (17.00 cM)⁵	retinoid X receptor alpha^{1, 5}	88.96(n)¹ 98.48(a)¹	20181¹ NM_011305.3¹ NP_035435.1¹ AI647710⁵ AK020634⁵ (see all 17)

About this table Species with no ortholog for RXRA

ENSEMBL Gene Tree for RXRA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RXRA gene

NR4A3² ESRRA² RXRG² PGR² ESR2² ESRRB² NR4A2² HNF4G²

ESRRG² NR2E1² NR2F6² NR5A2² NR3C2² NR4A1² NR2F1² NR5A1²

NR3C1² NR2E3² AR² NR2F2² ESR1² NR2C1² HNF4A² RXRB²

NR6A1² NR2C2²

RXRA for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/1083 NCBI SNPs in RXRA are shown (see all 1083 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 459)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
	rs1045570^1,2	C,F,O,A,H	137332311(+)	`TGGCCG/TCAGGT`	1	--	ut3¹ ese³		21	MN EA NA NS	2650
	rs9615^1,2	C,F,A,H	137331525(+)	`TCGTGG/CAGCTG`	1	--	ut3¹		14	MN NA NS EA	920
--	rs12343323^1,2	C,F,A,H	106756978(+)	`ACTGCT/CGACCT`	1	--	ng5¹		5	NS	172
--	rs4842194^1,2	C,F,A,H	137330560(+)	`GCCTTT/CTGCAG`	1	--	ut3¹ ese³		10	MN NS NA EA	536
	rs3132291^1,2	C,F,A	106796838(-)	`GGCTCT/CGGGCA`	1	--	ng3¹		13	NA NS EA WA	530
	rs7028673^1,2	C,F,A	106755935(+)	`GGCACC/GCAGCG`	1	--	ng5¹		5	NS EA WA	460
	rs7869783^1,2	C,F,A	106756789(+)	`TGAGCG/ATCCGG`	1	--	ng5¹		9	NS EA	590
	rs11103704^1,2	C,F,A	106755763(+)	`GTGAGG/ATAAGA`	1	--	ng5¹		15	NS EA NA WA	1070
	rs1805345^1,2	C,F,H	137321050(+)	`GAACAG/TCGCCC`	2	S I	ref¹ mis¹ ese³		8	NA MN EA NS	660
	rs1805346^1,2	C,F,H	137328833(+)	`TTTCCG/ATTGCT`	1	--	ut3¹ ese³		5	NA NS EA	514

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HapMap Linkage Disequilibrium images for RXRA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for RXRA
8 CNVs: 30337 52739 4659 52740 30338 4660 52741 70818
1 Indel: 100801

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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RXRA for disorders About GeneDecksing

OMIM: 180245

10/93 Novoseek disease relationships for RXRA gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nuclear accumulation	3.86	4	11001945 (3), 19556345 (1)
leiomyoma	3.22	7	17170071 (6), 10582693 (1)
multifocal hyperplasia	2.98	1	12183441 (1)
alcoholic cardiomyopathy	2.93	2	19791468 (2)
acute promyelocytic leukemia	2.84	6	18408763 (5), 15121864 (1)
carcinoma hepatocellular	2.82	25	11826406 (6), 18451248 (3), 15010815 (3), 11606411 (3) (see all 13)
embryonal carcinoma	2.69	4	9892176 (1), 9751115 (1), 7624356 (1), 14555536 (1)
intraepithelial prostatic neoplasia	1.93	2	15006913 (1), 12183441 (1)
fibrosis liver	1.83	4	15566521 (4)
high-grade prostatic intraepithelial neoplasia	1.81	2	15006913 (2)

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Genetic Association Database: RXRA
Human Genome Epidemiology Navigator: RXRA (24 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/436 PubMed articles for RXRA gene (see all 436 ):

Nuclear receptor that identifies a novel retinoic acid response pathway. (PubMed id 2159111)^{2, 3, 4} Mangelsdorf D.J.... Evans R.M. (1990)
Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. (PubMed id 16912044)^{1, 3, 4} Choi S.J.... Chung C.H. (2006)
9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. (PubMed id 16574651)^{1, 3, 4} Singh R.R.... Kumar R. (2006)
The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity. (PubMed id 14981089)^{1, 3, 4} Takano Y....Okano Y. (2004)
Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)^{3, 6} Feng J....Sommer S.S. (2005)
ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PubMed id 15047147)^{3, 4} Bu H.... Zhu Y.J. (2004)
PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PubMed id 11259580)^{3, 4} Mathur M.... Samuels H.H. (2001)
A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)^{3, 4} Lee S.-K.... Lee J.W. (1999)
High-resolution solution structure of the retinoid X receptor DNA- binding domain. (PubMed id 9698548)^{3, 4} Holmbeck S.M....Wright P.E. (1998)
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. (PubMed id 9267036)^{3, 4} Chen H.... Evans R.M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6256	HGNC: 10477	AceView: RXRA	Ensembl:ENSG00000186350	euGenes: HUgn6256
ECgene: RXRA	Kegg: 6256	H-InvDB: RXRA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RXRA	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/rxra/
Wikipedia	http://en.wikipedia.org/wiki/Retinoid_X_receptor

Intellectual Property for RXRA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for RXRA gene:

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GeneCards and IP:

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protein-coding GIFtS: 67

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